Natural‐Based Nanocomposites for Bone Tissue Engineering and Regenerative Medicine: A Review
Tissue engineering and regenerative medicine has been providing exciting technologies for the development of functional substitutes aimed to repair and regenerate damaged tissues and organs. Inspired by the hierarchical nature of bone, nanostructured biomaterials are gaining a singular attention for...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Pina, Sandra [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Rechteinformationen: |
Nutzungsrecht: © 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
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| Systematik: |
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| Übergeordnetes Werk: |
Enthalten in: Advanced materials - Weinheim : Wiley-VCH Verl., 1988, 27(2015), 7, Seite 1143-1169 |
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| Übergeordnetes Werk: |
volume:27 ; year:2015 ; number:7 ; pages:1143-1169 |
| Links: |
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| DOI / URN: |
10.1002/adma.201403354 |
|---|
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OLC195830803X |
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| 520 | |a Tissue engineering and regenerative medicine has been providing exciting technologies for the development of functional substitutes aimed to repair and regenerate damaged tissues and organs. Inspired by the hierarchical nature of bone, nanostructured biomaterials are gaining a singular attention for tissue engineering, owing their ability to promote cell adhesion and proliferation, and hence new bone growth, compared with conventional microsized materials. Of particular interest are nanocomposites involving biopolymeric matrices and bioactive nanosized fillers. Biodegradability, high mechanical strength, and osteointegration and formation of ligamentous tissue are properties required for such materials. Biopolymers are advantageous due to their similarities with extracellular matrices, specific degradation rates, and good biological performance. By its turn, calcium phosphates possess favorable osteoconductivity, resorbability, and biocompatibility. Herein, an overview on the available natural polymer/calcium phosphate nanocomposite materials, their design, and properties is presented. Scaffolds, hydrogels, and fibers as biomimetic strategies for tissue engineering, and processing methodologies are described. The specific biological properties of the nanocomposites, as well as their interaction with cells, including the use of bioactive molecules, are highlighted. Nanocomposites in vivo studies using animal models are also reviewed and discussed. Nanocomposite scaffolds combining biopolymers and calcium phosphate nanoparticles have a great potential in tissue engineering and regenerative medicine because of their ability to mimic the hierarchical structure and mechanical properties of bone tissue. They can be functionalized with cells and suitable biochemical signals, which promote tissue regeneration. | ||
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| 650 | 4 | |a natural polymers | |
| 650 | 4 | |a nanocomposites | |
| 650 | 4 | |a regenerative medicine | |
| 650 | 4 | |a bone tissue engineering | |
| 650 | 4 | |a Stem Cells - metabolism | |
| 650 | 4 | |a Biopolymers - metabolism | |
| 650 | 4 | |a Intercellular Signaling Peptides and Proteins - chemistry | |
| 650 | 4 | |a Nanocomposites - chemistry | |
| 650 | 4 | |a Proteins - chemistry | |
| 650 | 4 | |a Nanocomposites - therapeutic use | |
| 650 | 4 | |a Proteins - metabolism | |
| 650 | 4 | |a Nanocomposites - ultrastructure | |
| 650 | 4 | |a Stem Cells - cytology | |
| 650 | 4 | |a Biopolymers - chemistry | |
| 650 | 4 | |a Calcium Phosphates - chemistry | |
| 650 | 4 | |a Biocompatible Materials - therapeutic use | |
| 650 | 4 | |a Intercellular Signaling Peptides and Proteins - metabolism | |
| 650 | 4 | |a Hydrogels - chemistry | |
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10.1002/adma.201403354 doi PQ20160617 (DE-627)OLC195830803X (DE-599)GBVOLC195830803X (PRQ)c2254-eae5786eecbdde677156275dd6658f14ffd49188b4d7b83ab90d2f301dbf1e463 (KEY)0178503620150000027000701143naturalbasednanocompositesforbonetissueengineering DE-627 ger DE-627 rakwb eng 620 540 DE-101 540 AVZ UA 1538 AVZ rvk Pina, Sandra verfasserin aut Natural‐Based Nanocomposites for Bone Tissue Engineering and Regenerative Medicine: A Review 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Tissue engineering and regenerative medicine has been providing exciting technologies for the development of functional substitutes aimed to repair and regenerate damaged tissues and organs. Inspired by the hierarchical nature of bone, nanostructured biomaterials are gaining a singular attention for tissue engineering, owing their ability to promote cell adhesion and proliferation, and hence new bone growth, compared with conventional microsized materials. Of particular interest are nanocomposites involving biopolymeric matrices and bioactive nanosized fillers. Biodegradability, high mechanical strength, and osteointegration and formation of ligamentous tissue are properties required for such materials. Biopolymers are advantageous due to their similarities with extracellular matrices, specific degradation rates, and good biological performance. By its turn, calcium phosphates possess favorable osteoconductivity, resorbability, and biocompatibility. Herein, an overview on the available natural polymer/calcium phosphate nanocomposite materials, their design, and properties is presented. Scaffolds, hydrogels, and fibers as biomimetic strategies for tissue engineering, and processing methodologies are described. The specific biological properties of the nanocomposites, as well as their interaction with cells, including the use of bioactive molecules, are highlighted. Nanocomposites in vivo studies using animal models are also reviewed and discussed. Nanocomposite scaffolds combining biopolymers and calcium phosphate nanoparticles have a great potential in tissue engineering and regenerative medicine because of their ability to mimic the hierarchical structure and mechanical properties of bone tissue. They can be functionalized with cells and suitable biochemical signals, which promote tissue regeneration. Nutzungsrecht: © 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. calcium phosphates natural polymers nanocomposites regenerative medicine bone tissue engineering Stem Cells - metabolism Biopolymers - metabolism Intercellular Signaling Peptides and Proteins - chemistry Nanocomposites - chemistry Proteins - chemistry Nanocomposites - therapeutic use Proteins - metabolism Nanocomposites - ultrastructure Stem Cells - cytology Biopolymers - chemistry Calcium Phosphates - chemistry Biocompatible Materials - therapeutic use Intercellular Signaling Peptides and Proteins - metabolism Hydrogels - chemistry Biocompatible Materials - chemistry Oliveira, Joaquim M oth Reis, Rui L oth Enthalten in Advanced materials Weinheim : Wiley-VCH Verl., 1988 27(2015), 7, Seite 1143-1169 (DE-627)130815152 (DE-600)1012489-5 (DE-576)023057149 0935-9648 nnns volume:27 year:2015 number:7 pages:1143-1169 http://dx.doi.org/10.1002/adma.201403354 Volltext http://onlinelibrary.wiley.com/doi/10.1002/adma.201403354/abstract http://www.ncbi.nlm.nih.gov/pubmed/25580589 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_95 GBV_ILN_267 GBV_ILN_2004 GBV_ILN_2016 GBV_ILN_2018 GBV_ILN_2095 GBV_ILN_2185 GBV_ILN_4012 GBV_ILN_4306 UA 1538 AR 27 2015 7 1143-1169 |
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10.1002/adma.201403354 doi PQ20160617 (DE-627)OLC195830803X (DE-599)GBVOLC195830803X (PRQ)c2254-eae5786eecbdde677156275dd6658f14ffd49188b4d7b83ab90d2f301dbf1e463 (KEY)0178503620150000027000701143naturalbasednanocompositesforbonetissueengineering DE-627 ger DE-627 rakwb eng 620 540 DE-101 540 AVZ UA 1538 AVZ rvk Pina, Sandra verfasserin aut Natural‐Based Nanocomposites for Bone Tissue Engineering and Regenerative Medicine: A Review 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Tissue engineering and regenerative medicine has been providing exciting technologies for the development of functional substitutes aimed to repair and regenerate damaged tissues and organs. Inspired by the hierarchical nature of bone, nanostructured biomaterials are gaining a singular attention for tissue engineering, owing their ability to promote cell adhesion and proliferation, and hence new bone growth, compared with conventional microsized materials. Of particular interest are nanocomposites involving biopolymeric matrices and bioactive nanosized fillers. Biodegradability, high mechanical strength, and osteointegration and formation of ligamentous tissue are properties required for such materials. Biopolymers are advantageous due to their similarities with extracellular matrices, specific degradation rates, and good biological performance. By its turn, calcium phosphates possess favorable osteoconductivity, resorbability, and biocompatibility. Herein, an overview on the available natural polymer/calcium phosphate nanocomposite materials, their design, and properties is presented. Scaffolds, hydrogels, and fibers as biomimetic strategies for tissue engineering, and processing methodologies are described. The specific biological properties of the nanocomposites, as well as their interaction with cells, including the use of bioactive molecules, are highlighted. Nanocomposites in vivo studies using animal models are also reviewed and discussed. Nanocomposite scaffolds combining biopolymers and calcium phosphate nanoparticles have a great potential in tissue engineering and regenerative medicine because of their ability to mimic the hierarchical structure and mechanical properties of bone tissue. They can be functionalized with cells and suitable biochemical signals, which promote tissue regeneration. Nutzungsrecht: © 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. calcium phosphates natural polymers nanocomposites regenerative medicine bone tissue engineering Stem Cells - metabolism Biopolymers - metabolism Intercellular Signaling Peptides and Proteins - chemistry Nanocomposites - chemistry Proteins - chemistry Nanocomposites - therapeutic use Proteins - metabolism Nanocomposites - ultrastructure Stem Cells - cytology Biopolymers - chemistry Calcium Phosphates - chemistry Biocompatible Materials - therapeutic use Intercellular Signaling Peptides and Proteins - metabolism Hydrogels - chemistry Biocompatible Materials - chemistry Oliveira, Joaquim M oth Reis, Rui L oth Enthalten in Advanced materials Weinheim : Wiley-VCH Verl., 1988 27(2015), 7, Seite 1143-1169 (DE-627)130815152 (DE-600)1012489-5 (DE-576)023057149 0935-9648 nnns volume:27 year:2015 number:7 pages:1143-1169 http://dx.doi.org/10.1002/adma.201403354 Volltext http://onlinelibrary.wiley.com/doi/10.1002/adma.201403354/abstract http://www.ncbi.nlm.nih.gov/pubmed/25580589 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_95 GBV_ILN_267 GBV_ILN_2004 GBV_ILN_2016 GBV_ILN_2018 GBV_ILN_2095 GBV_ILN_2185 GBV_ILN_4012 GBV_ILN_4306 UA 1538 AR 27 2015 7 1143-1169 |
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10.1002/adma.201403354 doi PQ20160617 (DE-627)OLC195830803X (DE-599)GBVOLC195830803X (PRQ)c2254-eae5786eecbdde677156275dd6658f14ffd49188b4d7b83ab90d2f301dbf1e463 (KEY)0178503620150000027000701143naturalbasednanocompositesforbonetissueengineering DE-627 ger DE-627 rakwb eng 620 540 DE-101 540 AVZ UA 1538 AVZ rvk Pina, Sandra verfasserin aut Natural‐Based Nanocomposites for Bone Tissue Engineering and Regenerative Medicine: A Review 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Tissue engineering and regenerative medicine has been providing exciting technologies for the development of functional substitutes aimed to repair and regenerate damaged tissues and organs. Inspired by the hierarchical nature of bone, nanostructured biomaterials are gaining a singular attention for tissue engineering, owing their ability to promote cell adhesion and proliferation, and hence new bone growth, compared with conventional microsized materials. Of particular interest are nanocomposites involving biopolymeric matrices and bioactive nanosized fillers. Biodegradability, high mechanical strength, and osteointegration and formation of ligamentous tissue are properties required for such materials. Biopolymers are advantageous due to their similarities with extracellular matrices, specific degradation rates, and good biological performance. By its turn, calcium phosphates possess favorable osteoconductivity, resorbability, and biocompatibility. Herein, an overview on the available natural polymer/calcium phosphate nanocomposite materials, their design, and properties is presented. Scaffolds, hydrogels, and fibers as biomimetic strategies for tissue engineering, and processing methodologies are described. The specific biological properties of the nanocomposites, as well as their interaction with cells, including the use of bioactive molecules, are highlighted. Nanocomposites in vivo studies using animal models are also reviewed and discussed. Nanocomposite scaffolds combining biopolymers and calcium phosphate nanoparticles have a great potential in tissue engineering and regenerative medicine because of their ability to mimic the hierarchical structure and mechanical properties of bone tissue. They can be functionalized with cells and suitable biochemical signals, which promote tissue regeneration. Nutzungsrecht: © 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. calcium phosphates natural polymers nanocomposites regenerative medicine bone tissue engineering Stem Cells - metabolism Biopolymers - metabolism Intercellular Signaling Peptides and Proteins - chemistry Nanocomposites - chemistry Proteins - chemistry Nanocomposites - therapeutic use Proteins - metabolism Nanocomposites - ultrastructure Stem Cells - cytology Biopolymers - chemistry Calcium Phosphates - chemistry Biocompatible Materials - therapeutic use Intercellular Signaling Peptides and Proteins - metabolism Hydrogels - chemistry Biocompatible Materials - chemistry Oliveira, Joaquim M oth Reis, Rui L oth Enthalten in Advanced materials Weinheim : Wiley-VCH Verl., 1988 27(2015), 7, Seite 1143-1169 (DE-627)130815152 (DE-600)1012489-5 (DE-576)023057149 0935-9648 nnns volume:27 year:2015 number:7 pages:1143-1169 http://dx.doi.org/10.1002/adma.201403354 Volltext http://onlinelibrary.wiley.com/doi/10.1002/adma.201403354/abstract http://www.ncbi.nlm.nih.gov/pubmed/25580589 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_95 GBV_ILN_267 GBV_ILN_2004 GBV_ILN_2016 GBV_ILN_2018 GBV_ILN_2095 GBV_ILN_2185 GBV_ILN_4012 GBV_ILN_4306 UA 1538 AR 27 2015 7 1143-1169 |
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10.1002/adma.201403354 doi PQ20160617 (DE-627)OLC195830803X (DE-599)GBVOLC195830803X (PRQ)c2254-eae5786eecbdde677156275dd6658f14ffd49188b4d7b83ab90d2f301dbf1e463 (KEY)0178503620150000027000701143naturalbasednanocompositesforbonetissueengineering DE-627 ger DE-627 rakwb eng 620 540 DE-101 540 AVZ UA 1538 AVZ rvk Pina, Sandra verfasserin aut Natural‐Based Nanocomposites for Bone Tissue Engineering and Regenerative Medicine: A Review 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Tissue engineering and regenerative medicine has been providing exciting technologies for the development of functional substitutes aimed to repair and regenerate damaged tissues and organs. Inspired by the hierarchical nature of bone, nanostructured biomaterials are gaining a singular attention for tissue engineering, owing their ability to promote cell adhesion and proliferation, and hence new bone growth, compared with conventional microsized materials. Of particular interest are nanocomposites involving biopolymeric matrices and bioactive nanosized fillers. Biodegradability, high mechanical strength, and osteointegration and formation of ligamentous tissue are properties required for such materials. Biopolymers are advantageous due to their similarities with extracellular matrices, specific degradation rates, and good biological performance. By its turn, calcium phosphates possess favorable osteoconductivity, resorbability, and biocompatibility. Herein, an overview on the available natural polymer/calcium phosphate nanocomposite materials, their design, and properties is presented. Scaffolds, hydrogels, and fibers as biomimetic strategies for tissue engineering, and processing methodologies are described. The specific biological properties of the nanocomposites, as well as their interaction with cells, including the use of bioactive molecules, are highlighted. Nanocomposites in vivo studies using animal models are also reviewed and discussed. Nanocomposite scaffolds combining biopolymers and calcium phosphate nanoparticles have a great potential in tissue engineering and regenerative medicine because of their ability to mimic the hierarchical structure and mechanical properties of bone tissue. They can be functionalized with cells and suitable biochemical signals, which promote tissue regeneration. Nutzungsrecht: © 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. calcium phosphates natural polymers nanocomposites regenerative medicine bone tissue engineering Stem Cells - metabolism Biopolymers - metabolism Intercellular Signaling Peptides and Proteins - chemistry Nanocomposites - chemistry Proteins - chemistry Nanocomposites - therapeutic use Proteins - metabolism Nanocomposites - ultrastructure Stem Cells - cytology Biopolymers - chemistry Calcium Phosphates - chemistry Biocompatible Materials - therapeutic use Intercellular Signaling Peptides and Proteins - metabolism Hydrogels - chemistry Biocompatible Materials - chemistry Oliveira, Joaquim M oth Reis, Rui L oth Enthalten in Advanced materials Weinheim : Wiley-VCH Verl., 1988 27(2015), 7, Seite 1143-1169 (DE-627)130815152 (DE-600)1012489-5 (DE-576)023057149 0935-9648 nnns volume:27 year:2015 number:7 pages:1143-1169 http://dx.doi.org/10.1002/adma.201403354 Volltext http://onlinelibrary.wiley.com/doi/10.1002/adma.201403354/abstract http://www.ncbi.nlm.nih.gov/pubmed/25580589 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_95 GBV_ILN_267 GBV_ILN_2004 GBV_ILN_2016 GBV_ILN_2018 GBV_ILN_2095 GBV_ILN_2185 GBV_ILN_4012 GBV_ILN_4306 UA 1538 AR 27 2015 7 1143-1169 |
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natural‐based nanocomposites for bone tissue engineering and regenerative medicine: a review |
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Natural‐Based Nanocomposites for Bone Tissue Engineering and Regenerative Medicine: A Review |
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Tissue engineering and regenerative medicine has been providing exciting technologies for the development of functional substitutes aimed to repair and regenerate damaged tissues and organs. Inspired by the hierarchical nature of bone, nanostructured biomaterials are gaining a singular attention for tissue engineering, owing their ability to promote cell adhesion and proliferation, and hence new bone growth, compared with conventional microsized materials. Of particular interest are nanocomposites involving biopolymeric matrices and bioactive nanosized fillers. Biodegradability, high mechanical strength, and osteointegration and formation of ligamentous tissue are properties required for such materials. Biopolymers are advantageous due to their similarities with extracellular matrices, specific degradation rates, and good biological performance. By its turn, calcium phosphates possess favorable osteoconductivity, resorbability, and biocompatibility. Herein, an overview on the available natural polymer/calcium phosphate nanocomposite materials, their design, and properties is presented. Scaffolds, hydrogels, and fibers as biomimetic strategies for tissue engineering, and processing methodologies are described. The specific biological properties of the nanocomposites, as well as their interaction with cells, including the use of bioactive molecules, are highlighted. Nanocomposites in vivo studies using animal models are also reviewed and discussed. Nanocomposite scaffolds combining biopolymers and calcium phosphate nanoparticles have a great potential in tissue engineering and regenerative medicine because of their ability to mimic the hierarchical structure and mechanical properties of bone tissue. They can be functionalized with cells and suitable biochemical signals, which promote tissue regeneration. |
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Tissue engineering and regenerative medicine has been providing exciting technologies for the development of functional substitutes aimed to repair and regenerate damaged tissues and organs. Inspired by the hierarchical nature of bone, nanostructured biomaterials are gaining a singular attention for tissue engineering, owing their ability to promote cell adhesion and proliferation, and hence new bone growth, compared with conventional microsized materials. Of particular interest are nanocomposites involving biopolymeric matrices and bioactive nanosized fillers. Biodegradability, high mechanical strength, and osteointegration and formation of ligamentous tissue are properties required for such materials. Biopolymers are advantageous due to their similarities with extracellular matrices, specific degradation rates, and good biological performance. By its turn, calcium phosphates possess favorable osteoconductivity, resorbability, and biocompatibility. Herein, an overview on the available natural polymer/calcium phosphate nanocomposite materials, their design, and properties is presented. Scaffolds, hydrogels, and fibers as biomimetic strategies for tissue engineering, and processing methodologies are described. The specific biological properties of the nanocomposites, as well as their interaction with cells, including the use of bioactive molecules, are highlighted. Nanocomposites in vivo studies using animal models are also reviewed and discussed. Nanocomposite scaffolds combining biopolymers and calcium phosphate nanoparticles have a great potential in tissue engineering and regenerative medicine because of their ability to mimic the hierarchical structure and mechanical properties of bone tissue. They can be functionalized with cells and suitable biochemical signals, which promote tissue regeneration. |
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Tissue engineering and regenerative medicine has been providing exciting technologies for the development of functional substitutes aimed to repair and regenerate damaged tissues and organs. Inspired by the hierarchical nature of bone, nanostructured biomaterials are gaining a singular attention for tissue engineering, owing their ability to promote cell adhesion and proliferation, and hence new bone growth, compared with conventional microsized materials. Of particular interest are nanocomposites involving biopolymeric matrices and bioactive nanosized fillers. Biodegradability, high mechanical strength, and osteointegration and formation of ligamentous tissue are properties required for such materials. Biopolymers are advantageous due to their similarities with extracellular matrices, specific degradation rates, and good biological performance. By its turn, calcium phosphates possess favorable osteoconductivity, resorbability, and biocompatibility. Herein, an overview on the available natural polymer/calcium phosphate nanocomposite materials, their design, and properties is presented. Scaffolds, hydrogels, and fibers as biomimetic strategies for tissue engineering, and processing methodologies are described. The specific biological properties of the nanocomposites, as well as their interaction with cells, including the use of bioactive molecules, are highlighted. Nanocomposites in vivo studies using animal models are also reviewed and discussed. Nanocomposite scaffolds combining biopolymers and calcium phosphate nanoparticles have a great potential in tissue engineering and regenerative medicine because of their ability to mimic the hierarchical structure and mechanical properties of bone tissue. They can be functionalized with cells and suitable biochemical signals, which promote tissue regeneration. |
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Scaffolds, hydrogels, and fibers as biomimetic strategies for tissue engineering, and processing methodologies are described. The specific biological properties of the nanocomposites, as well as their interaction with cells, including the use of bioactive molecules, are highlighted. Nanocomposites in vivo studies using animal models are also reviewed and discussed. Nanocomposite scaffolds combining biopolymers and calcium phosphate nanoparticles have a great potential in tissue engineering and regenerative medicine because of their ability to mimic the hierarchical structure and mechanical properties of bone tissue. They can be functionalized with cells and suitable biochemical signals, which promote tissue regeneration.</subfield></datafield><datafield tag="540" ind1=" " ind2=" "><subfield code="a">Nutzungsrecht: © 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</subfield></datafield><datafield tag="540" ind1=" " ind2=" "><subfield code="a">© 2015 WILEY-VCH Verlag GmbH & Co. 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chemistry</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Nanocomposites - therapeutic use</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Proteins - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Nanocomposites - ultrastructure</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Stem Cells - cytology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Biopolymers - chemistry</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Calcium Phosphates - chemistry</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Biocompatible Materials - therapeutic use</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Intercellular Signaling Peptides and Proteins - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Hydrogels - chemistry</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Biocompatible Materials - chemistry</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Oliveira, Joaquim M</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Reis, Rui L</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Advanced materials</subfield><subfield code="d">Weinheim : Wiley-VCH Verl., 1988</subfield><subfield code="g">27(2015), 7, Seite 1143-1169</subfield><subfield code="w">(DE-627)130815152</subfield><subfield code="w">(DE-600)1012489-5</subfield><subfield code="w">(DE-576)023057149</subfield><subfield code="x">0935-9648</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:27</subfield><subfield code="g">year:2015</subfield><subfield code="g">number:7</subfield><subfield code="g">pages:1143-1169</subfield></datafield><datafield tag="856" ind1="4" ind2="1"><subfield code="u">http://dx.doi.org/10.1002/adma.201403354</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">http://onlinelibrary.wiley.com/doi/10.1002/adma.201403354/abstract</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">http://www.ncbi.nlm.nih.gov/pubmed/25580589</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_OLC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-TEC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-CHE</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-DE-84</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_267</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2004</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2016</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2018</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2095</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2185</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="936" ind1="r" ind2="v"><subfield code="a">UA 1538</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">27</subfield><subfield code="j">2015</subfield><subfield code="e">7</subfield><subfield code="h">1143-1169</subfield></datafield></record></collection>
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