The prevalence of vertebral fractures in spondyloarthritis: relation to disease characteristics, bone mineral density, syndesmophytes and history of back pain and trauma
Introduction: An increased risk of vertebral fracture (VF) is one of the extra-articular manifestations of spondyloarthropathy (SpA). The prevalence of moderate to severe VFs visualized by radiography (Rx) in patients with SpA in daily practice is unknown until imaging of the full spine is available...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Geusens, Piet [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Übergeordnetes Werk: |
Enthalten in: Arthritis research & therapy - London : BioMed Central, 2003, (2015) |
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| Übergeordnetes Werk: |
year:2015 |
| Links: |
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| DOI / URN: |
10.1186/s13075-015-0809-9 |
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OLC1961017504 |
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| 245 | 1 | 4 | |a The prevalence of vertebral fractures in spondyloarthritis: relation to disease characteristics, bone mineral density, syndesmophytes and history of back pain and trauma |
| 264 | 1 | |c 2015 | |
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| 520 | |a Introduction: An increased risk of vertebral fracture (VF) is one of the extra-articular manifestations of spondyloarthropathy (SpA). The prevalence of moderate to severe VFs visualized by radiography (Rx) in patients with SpA in daily practice is unknown until imaging of the full spine is available, as most VFs do not present with clinical signs and symptoms of an acute fracture. Methods: We evaluated the prevalence of VFs (>25 % loss in height) on available Rx and dual-energy X-ray absorptiometry (DXA) images in 390 consecutive patients with SpA in daily practice. We assessed their association with disease characteristics, bone mineral density, the modified Stoke Ankylosing Spondylitis Spinal Score, and history of trauma. Results: Forty-six patients (11.8 %) had Rx VF (56.4 % men, 93.5 % in the thoracic spine), and 44.5 % had multiple VFs. Compared with patients without VF, patients with VF were older (52.2 vs. 47.3 years, p < 0.01; range 25-84 years), had lower femoral neck T-scores (-1.1 vs. -0.7; p < 0.05), and had a marginally higher modified Stoke Ankylosing Spondylitis Spinal Score (11.7 vs. 7.0; p = 0.06). Among patients with VFs, 15.2 % had a history of trauma with acute back pain (p < 0.001 vs. no VF). The reliability of DXA for diagnosing radiographic VFs was high (kappa 0.90). Conclusions: Moderate to severe VFs are found in more than 10 % of patients with SpA before the age of 40 years in 5 % of women and 9 % in men. Most VFs are located in the thoracic region, are related to low femoral neck bonemineral density and to stiffening of the spine, and are only rarely related to trauma history. DXA is a useful alternative for diagnosing VFs. This study was supported by Hasselt University and Transnationale Universiteit Limburg, Maastricht University Medical Centre. It was also supported by an unrestricted grant from AbbVie for a non-interventional study survey. spondyloarthropathy; bone mineral density; vertebral fracture; vertebral fracture assessment | ||
| 650 | 4 | |a Spondyloarthropathy | |
| 650 | 4 | |a Vertebral fracture | |
| 650 | 4 | |a Vertebral fracture assessment | |
| 650 | 4 | |a Bone mineral density | |
| 700 | 1 | |a De Winter, Liesbeth |4 oth | |
| 700 | 1 | |a Quaden, Dana |4 oth | |
| 700 | 1 | |a Vanhoof, Johan |4 oth | |
| 700 | 1 | |a Vosse, Debby |4 oth | |
| 700 | 1 | |a Van den Bergh, Joop |4 oth | |
| 700 | 1 | |a Somers, Veerle |4 oth | |
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10.1186/s13075-015-0809-9 doi PQ20160617 (DE-627)OLC1961017504 (DE-599)GBVOLC1961017504 (PRQ)uha_dspace_oai_uhdspace_uhasselt_be_1942_197890 (KEY)0427448220150000000000000000prevalenceofvertebralfracturesinspondyloarthritisr DE-627 ger DE-627 rakwb eng 610 DNB Geusens, Piet verfasserin aut The prevalence of vertebral fractures in spondyloarthritis: relation to disease characteristics, bone mineral density, syndesmophytes and history of back pain and trauma 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Introduction: An increased risk of vertebral fracture (VF) is one of the extra-articular manifestations of spondyloarthropathy (SpA). The prevalence of moderate to severe VFs visualized by radiography (Rx) in patients with SpA in daily practice is unknown until imaging of the full spine is available, as most VFs do not present with clinical signs and symptoms of an acute fracture. Methods: We evaluated the prevalence of VFs (>25 % loss in height) on available Rx and dual-energy X-ray absorptiometry (DXA) images in 390 consecutive patients with SpA in daily practice. We assessed their association with disease characteristics, bone mineral density, the modified Stoke Ankylosing Spondylitis Spinal Score, and history of trauma. Results: Forty-six patients (11.8 %) had Rx VF (56.4 % men, 93.5 % in the thoracic spine), and 44.5 % had multiple VFs. Compared with patients without VF, patients with VF were older (52.2 vs. 47.3 years, p < 0.01; range 25-84 years), had lower femoral neck T-scores (-1.1 vs. -0.7; p < 0.05), and had a marginally higher modified Stoke Ankylosing Spondylitis Spinal Score (11.7 vs. 7.0; p = 0.06). Among patients with VFs, 15.2 % had a history of trauma with acute back pain (p < 0.001 vs. no VF). The reliability of DXA for diagnosing radiographic VFs was high (kappa 0.90). Conclusions: Moderate to severe VFs are found in more than 10 % of patients with SpA before the age of 40 years in 5 % of women and 9 % in men. Most VFs are located in the thoracic region, are related to low femoral neck bonemineral density and to stiffening of the spine, and are only rarely related to trauma history. DXA is a useful alternative for diagnosing VFs. This study was supported by Hasselt University and Transnationale Universiteit Limburg, Maastricht University Medical Centre. It was also supported by an unrestricted grant from AbbVie for a non-interventional study survey. spondyloarthropathy; bone mineral density; vertebral fracture; vertebral fracture assessment Spondyloarthropathy Vertebral fracture Vertebral fracture assessment Bone mineral density De Winter, Liesbeth oth Quaden, Dana oth Vanhoof, Johan oth Vosse, Debby oth Van den Bergh, Joop oth Somers, Veerle oth Enthalten in Arthritis research & therapy London : BioMed Central, 2003 (2015) (DE-627)363765530 (DE-600)2107602-9 (DE-576)379407604 1478-6354 nnns year:2015 http://dx.doi.org/10.1186/s13075-015-0809-9 Volltext http://hdl.handle.net/1942/19789 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-NED SSG-OLC-PHA SSG-OLC-DE-84 AR 2015 |
| spelling |
10.1186/s13075-015-0809-9 doi PQ20160617 (DE-627)OLC1961017504 (DE-599)GBVOLC1961017504 (PRQ)uha_dspace_oai_uhdspace_uhasselt_be_1942_197890 (KEY)0427448220150000000000000000prevalenceofvertebralfracturesinspondyloarthritisr DE-627 ger DE-627 rakwb eng 610 DNB Geusens, Piet verfasserin aut The prevalence of vertebral fractures in spondyloarthritis: relation to disease characteristics, bone mineral density, syndesmophytes and history of back pain and trauma 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Introduction: An increased risk of vertebral fracture (VF) is one of the extra-articular manifestations of spondyloarthropathy (SpA). The prevalence of moderate to severe VFs visualized by radiography (Rx) in patients with SpA in daily practice is unknown until imaging of the full spine is available, as most VFs do not present with clinical signs and symptoms of an acute fracture. Methods: We evaluated the prevalence of VFs (>25 % loss in height) on available Rx and dual-energy X-ray absorptiometry (DXA) images in 390 consecutive patients with SpA in daily practice. We assessed their association with disease characteristics, bone mineral density, the modified Stoke Ankylosing Spondylitis Spinal Score, and history of trauma. Results: Forty-six patients (11.8 %) had Rx VF (56.4 % men, 93.5 % in the thoracic spine), and 44.5 % had multiple VFs. Compared with patients without VF, patients with VF were older (52.2 vs. 47.3 years, p < 0.01; range 25-84 years), had lower femoral neck T-scores (-1.1 vs. -0.7; p < 0.05), and had a marginally higher modified Stoke Ankylosing Spondylitis Spinal Score (11.7 vs. 7.0; p = 0.06). Among patients with VFs, 15.2 % had a history of trauma with acute back pain (p < 0.001 vs. no VF). The reliability of DXA for diagnosing radiographic VFs was high (kappa 0.90). Conclusions: Moderate to severe VFs are found in more than 10 % of patients with SpA before the age of 40 years in 5 % of women and 9 % in men. Most VFs are located in the thoracic region, are related to low femoral neck bonemineral density and to stiffening of the spine, and are only rarely related to trauma history. DXA is a useful alternative for diagnosing VFs. This study was supported by Hasselt University and Transnationale Universiteit Limburg, Maastricht University Medical Centre. It was also supported by an unrestricted grant from AbbVie for a non-interventional study survey. spondyloarthropathy; bone mineral density; vertebral fracture; vertebral fracture assessment Spondyloarthropathy Vertebral fracture Vertebral fracture assessment Bone mineral density De Winter, Liesbeth oth Quaden, Dana oth Vanhoof, Johan oth Vosse, Debby oth Van den Bergh, Joop oth Somers, Veerle oth Enthalten in Arthritis research & therapy London : BioMed Central, 2003 (2015) (DE-627)363765530 (DE-600)2107602-9 (DE-576)379407604 1478-6354 nnns year:2015 http://dx.doi.org/10.1186/s13075-015-0809-9 Volltext http://hdl.handle.net/1942/19789 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-NED SSG-OLC-PHA SSG-OLC-DE-84 AR 2015 |
| allfields_unstemmed |
10.1186/s13075-015-0809-9 doi PQ20160617 (DE-627)OLC1961017504 (DE-599)GBVOLC1961017504 (PRQ)uha_dspace_oai_uhdspace_uhasselt_be_1942_197890 (KEY)0427448220150000000000000000prevalenceofvertebralfracturesinspondyloarthritisr DE-627 ger DE-627 rakwb eng 610 DNB Geusens, Piet verfasserin aut The prevalence of vertebral fractures in spondyloarthritis: relation to disease characteristics, bone mineral density, syndesmophytes and history of back pain and trauma 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Introduction: An increased risk of vertebral fracture (VF) is one of the extra-articular manifestations of spondyloarthropathy (SpA). The prevalence of moderate to severe VFs visualized by radiography (Rx) in patients with SpA in daily practice is unknown until imaging of the full spine is available, as most VFs do not present with clinical signs and symptoms of an acute fracture. Methods: We evaluated the prevalence of VFs (>25 % loss in height) on available Rx and dual-energy X-ray absorptiometry (DXA) images in 390 consecutive patients with SpA in daily practice. We assessed their association with disease characteristics, bone mineral density, the modified Stoke Ankylosing Spondylitis Spinal Score, and history of trauma. Results: Forty-six patients (11.8 %) had Rx VF (56.4 % men, 93.5 % in the thoracic spine), and 44.5 % had multiple VFs. Compared with patients without VF, patients with VF were older (52.2 vs. 47.3 years, p < 0.01; range 25-84 years), had lower femoral neck T-scores (-1.1 vs. -0.7; p < 0.05), and had a marginally higher modified Stoke Ankylosing Spondylitis Spinal Score (11.7 vs. 7.0; p = 0.06). Among patients with VFs, 15.2 % had a history of trauma with acute back pain (p < 0.001 vs. no VF). The reliability of DXA for diagnosing radiographic VFs was high (kappa 0.90). Conclusions: Moderate to severe VFs are found in more than 10 % of patients with SpA before the age of 40 years in 5 % of women and 9 % in men. Most VFs are located in the thoracic region, are related to low femoral neck bonemineral density and to stiffening of the spine, and are only rarely related to trauma history. DXA is a useful alternative for diagnosing VFs. This study was supported by Hasselt University and Transnationale Universiteit Limburg, Maastricht University Medical Centre. It was also supported by an unrestricted grant from AbbVie for a non-interventional study survey. spondyloarthropathy; bone mineral density; vertebral fracture; vertebral fracture assessment Spondyloarthropathy Vertebral fracture Vertebral fracture assessment Bone mineral density De Winter, Liesbeth oth Quaden, Dana oth Vanhoof, Johan oth Vosse, Debby oth Van den Bergh, Joop oth Somers, Veerle oth Enthalten in Arthritis research & therapy London : BioMed Central, 2003 (2015) (DE-627)363765530 (DE-600)2107602-9 (DE-576)379407604 1478-6354 nnns year:2015 http://dx.doi.org/10.1186/s13075-015-0809-9 Volltext http://hdl.handle.net/1942/19789 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-NED SSG-OLC-PHA SSG-OLC-DE-84 AR 2015 |
| allfieldsGer |
10.1186/s13075-015-0809-9 doi PQ20160617 (DE-627)OLC1961017504 (DE-599)GBVOLC1961017504 (PRQ)uha_dspace_oai_uhdspace_uhasselt_be_1942_197890 (KEY)0427448220150000000000000000prevalenceofvertebralfracturesinspondyloarthritisr DE-627 ger DE-627 rakwb eng 610 DNB Geusens, Piet verfasserin aut The prevalence of vertebral fractures in spondyloarthritis: relation to disease characteristics, bone mineral density, syndesmophytes and history of back pain and trauma 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Introduction: An increased risk of vertebral fracture (VF) is one of the extra-articular manifestations of spondyloarthropathy (SpA). The prevalence of moderate to severe VFs visualized by radiography (Rx) in patients with SpA in daily practice is unknown until imaging of the full spine is available, as most VFs do not present with clinical signs and symptoms of an acute fracture. Methods: We evaluated the prevalence of VFs (>25 % loss in height) on available Rx and dual-energy X-ray absorptiometry (DXA) images in 390 consecutive patients with SpA in daily practice. We assessed their association with disease characteristics, bone mineral density, the modified Stoke Ankylosing Spondylitis Spinal Score, and history of trauma. Results: Forty-six patients (11.8 %) had Rx VF (56.4 % men, 93.5 % in the thoracic spine), and 44.5 % had multiple VFs. Compared with patients without VF, patients with VF were older (52.2 vs. 47.3 years, p < 0.01; range 25-84 years), had lower femoral neck T-scores (-1.1 vs. -0.7; p < 0.05), and had a marginally higher modified Stoke Ankylosing Spondylitis Spinal Score (11.7 vs. 7.0; p = 0.06). Among patients with VFs, 15.2 % had a history of trauma with acute back pain (p < 0.001 vs. no VF). The reliability of DXA for diagnosing radiographic VFs was high (kappa 0.90). Conclusions: Moderate to severe VFs are found in more than 10 % of patients with SpA before the age of 40 years in 5 % of women and 9 % in men. Most VFs are located in the thoracic region, are related to low femoral neck bonemineral density and to stiffening of the spine, and are only rarely related to trauma history. DXA is a useful alternative for diagnosing VFs. This study was supported by Hasselt University and Transnationale Universiteit Limburg, Maastricht University Medical Centre. It was also supported by an unrestricted grant from AbbVie for a non-interventional study survey. spondyloarthropathy; bone mineral density; vertebral fracture; vertebral fracture assessment Spondyloarthropathy Vertebral fracture Vertebral fracture assessment Bone mineral density De Winter, Liesbeth oth Quaden, Dana oth Vanhoof, Johan oth Vosse, Debby oth Van den Bergh, Joop oth Somers, Veerle oth Enthalten in Arthritis research & therapy London : BioMed Central, 2003 (2015) (DE-627)363765530 (DE-600)2107602-9 (DE-576)379407604 1478-6354 nnns year:2015 http://dx.doi.org/10.1186/s13075-015-0809-9 Volltext http://hdl.handle.net/1942/19789 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-NED SSG-OLC-PHA SSG-OLC-DE-84 AR 2015 |
| allfieldsSound |
10.1186/s13075-015-0809-9 doi PQ20160617 (DE-627)OLC1961017504 (DE-599)GBVOLC1961017504 (PRQ)uha_dspace_oai_uhdspace_uhasselt_be_1942_197890 (KEY)0427448220150000000000000000prevalenceofvertebralfracturesinspondyloarthritisr DE-627 ger DE-627 rakwb eng 610 DNB Geusens, Piet verfasserin aut The prevalence of vertebral fractures in spondyloarthritis: relation to disease characteristics, bone mineral density, syndesmophytes and history of back pain and trauma 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Introduction: An increased risk of vertebral fracture (VF) is one of the extra-articular manifestations of spondyloarthropathy (SpA). The prevalence of moderate to severe VFs visualized by radiography (Rx) in patients with SpA in daily practice is unknown until imaging of the full spine is available, as most VFs do not present with clinical signs and symptoms of an acute fracture. Methods: We evaluated the prevalence of VFs (>25 % loss in height) on available Rx and dual-energy X-ray absorptiometry (DXA) images in 390 consecutive patients with SpA in daily practice. We assessed their association with disease characteristics, bone mineral density, the modified Stoke Ankylosing Spondylitis Spinal Score, and history of trauma. Results: Forty-six patients (11.8 %) had Rx VF (56.4 % men, 93.5 % in the thoracic spine), and 44.5 % had multiple VFs. Compared with patients without VF, patients with VF were older (52.2 vs. 47.3 years, p < 0.01; range 25-84 years), had lower femoral neck T-scores (-1.1 vs. -0.7; p < 0.05), and had a marginally higher modified Stoke Ankylosing Spondylitis Spinal Score (11.7 vs. 7.0; p = 0.06). Among patients with VFs, 15.2 % had a history of trauma with acute back pain (p < 0.001 vs. no VF). The reliability of DXA for diagnosing radiographic VFs was high (kappa 0.90). Conclusions: Moderate to severe VFs are found in more than 10 % of patients with SpA before the age of 40 years in 5 % of women and 9 % in men. Most VFs are located in the thoracic region, are related to low femoral neck bonemineral density and to stiffening of the spine, and are only rarely related to trauma history. DXA is a useful alternative for diagnosing VFs. This study was supported by Hasselt University and Transnationale Universiteit Limburg, Maastricht University Medical Centre. It was also supported by an unrestricted grant from AbbVie for a non-interventional study survey. spondyloarthropathy; bone mineral density; vertebral fracture; vertebral fracture assessment Spondyloarthropathy Vertebral fracture Vertebral fracture assessment Bone mineral density De Winter, Liesbeth oth Quaden, Dana oth Vanhoof, Johan oth Vosse, Debby oth Van den Bergh, Joop oth Somers, Veerle oth Enthalten in Arthritis research & therapy London : BioMed Central, 2003 (2015) (DE-627)363765530 (DE-600)2107602-9 (DE-576)379407604 1478-6354 nnns year:2015 http://dx.doi.org/10.1186/s13075-015-0809-9 Volltext http://hdl.handle.net/1942/19789 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-NED SSG-OLC-PHA SSG-OLC-DE-84 AR 2015 |
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Geusens, Piet @@aut@@ De Winter, Liesbeth @@oth@@ Quaden, Dana @@oth@@ Vanhoof, Johan @@oth@@ Vosse, Debby @@oth@@ Van den Bergh, Joop @@oth@@ Somers, Veerle @@oth@@ |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a2200265 4500</leader><controlfield tag="001">OLC1961017504</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230512151442.0</controlfield><controlfield tag="007">tu</controlfield><controlfield tag="008">160206s2015 xx ||||| 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/s13075-015-0809-9</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">PQ20160617</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)OLC1961017504</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBVOLC1961017504</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(PRQ)uha_dspace_oai_uhdspace_uhasselt_be_1942_197890</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(KEY)0427448220150000000000000000prevalenceofvertebralfracturesinspondyloarthritisr</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">DNB</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Geusens, Piet</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="4"><subfield code="a">The prevalence of vertebral fractures in spondyloarthritis: relation to disease characteristics, bone mineral density, syndesmophytes and history of back pain and trauma</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2015</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">ohne Hilfsmittel zu benutzen</subfield><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Band</subfield><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Introduction: An increased risk of vertebral fracture (VF) is one of the extra-articular manifestations of spondyloarthropathy (SpA). The prevalence of moderate to severe VFs visualized by radiography (Rx) in patients with SpA in daily practice is unknown until imaging of the full spine is available, as most VFs do not present with clinical signs and symptoms of an acute fracture. Methods: We evaluated the prevalence of VFs (>25 % loss in height) on available Rx and dual-energy X-ray absorptiometry (DXA) images in 390 consecutive patients with SpA in daily practice. We assessed their association with disease characteristics, bone mineral density, the modified Stoke Ankylosing Spondylitis Spinal Score, and history of trauma. Results: Forty-six patients (11.8 %) had Rx VF (56.4 % men, 93.5 % in the thoracic spine), and 44.5 % had multiple VFs. Compared with patients without VF, patients with VF were older (52.2 vs. 47.3 years, p < 0.01; range 25-84 years), had lower femoral neck T-scores (-1.1 vs. -0.7; p < 0.05), and had a marginally higher modified Stoke Ankylosing Spondylitis Spinal Score (11.7 vs. 7.0; p = 0.06). Among patients with VFs, 15.2 % had a history of trauma with acute back pain (p < 0.001 vs. no VF). The reliability of DXA for diagnosing radiographic VFs was high (kappa 0.90). Conclusions: Moderate to severe VFs are found in more than 10 % of patients with SpA before the age of 40 years in 5 % of women and 9 % in men. Most VFs are located in the thoracic region, are related to low femoral neck bonemineral density and to stiffening of the spine, and are only rarely related to trauma history. DXA is a useful alternative for diagnosing VFs. This study was supported by Hasselt University and Transnationale Universiteit Limburg, Maastricht University Medical Centre. 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prevalence of vertebral fractures in spondyloarthritis: relation to disease characteristics, bone mineral density, syndesmophytes and history of back pain and trauma |
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The prevalence of vertebral fractures in spondyloarthritis: relation to disease characteristics, bone mineral density, syndesmophytes and history of back pain and trauma |
| abstract |
Introduction: An increased risk of vertebral fracture (VF) is one of the extra-articular manifestations of spondyloarthropathy (SpA). The prevalence of moderate to severe VFs visualized by radiography (Rx) in patients with SpA in daily practice is unknown until imaging of the full spine is available, as most VFs do not present with clinical signs and symptoms of an acute fracture. Methods: We evaluated the prevalence of VFs (>25 % loss in height) on available Rx and dual-energy X-ray absorptiometry (DXA) images in 390 consecutive patients with SpA in daily practice. We assessed their association with disease characteristics, bone mineral density, the modified Stoke Ankylosing Spondylitis Spinal Score, and history of trauma. Results: Forty-six patients (11.8 %) had Rx VF (56.4 % men, 93.5 % in the thoracic spine), and 44.5 % had multiple VFs. Compared with patients without VF, patients with VF were older (52.2 vs. 47.3 years, p < 0.01; range 25-84 years), had lower femoral neck T-scores (-1.1 vs. -0.7; p < 0.05), and had a marginally higher modified Stoke Ankylosing Spondylitis Spinal Score (11.7 vs. 7.0; p = 0.06). Among patients with VFs, 15.2 % had a history of trauma with acute back pain (p < 0.001 vs. no VF). The reliability of DXA for diagnosing radiographic VFs was high (kappa 0.90). Conclusions: Moderate to severe VFs are found in more than 10 % of patients with SpA before the age of 40 years in 5 % of women and 9 % in men. Most VFs are located in the thoracic region, are related to low femoral neck bonemineral density and to stiffening of the spine, and are only rarely related to trauma history. DXA is a useful alternative for diagnosing VFs. This study was supported by Hasselt University and Transnationale Universiteit Limburg, Maastricht University Medical Centre. It was also supported by an unrestricted grant from AbbVie for a non-interventional study survey. spondyloarthropathy; bone mineral density; vertebral fracture; vertebral fracture assessment |
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Introduction: An increased risk of vertebral fracture (VF) is one of the extra-articular manifestations of spondyloarthropathy (SpA). The prevalence of moderate to severe VFs visualized by radiography (Rx) in patients with SpA in daily practice is unknown until imaging of the full spine is available, as most VFs do not present with clinical signs and symptoms of an acute fracture. Methods: We evaluated the prevalence of VFs (>25 % loss in height) on available Rx and dual-energy X-ray absorptiometry (DXA) images in 390 consecutive patients with SpA in daily practice. We assessed their association with disease characteristics, bone mineral density, the modified Stoke Ankylosing Spondylitis Spinal Score, and history of trauma. Results: Forty-six patients (11.8 %) had Rx VF (56.4 % men, 93.5 % in the thoracic spine), and 44.5 % had multiple VFs. Compared with patients without VF, patients with VF were older (52.2 vs. 47.3 years, p < 0.01; range 25-84 years), had lower femoral neck T-scores (-1.1 vs. -0.7; p < 0.05), and had a marginally higher modified Stoke Ankylosing Spondylitis Spinal Score (11.7 vs. 7.0; p = 0.06). Among patients with VFs, 15.2 % had a history of trauma with acute back pain (p < 0.001 vs. no VF). The reliability of DXA for diagnosing radiographic VFs was high (kappa 0.90). Conclusions: Moderate to severe VFs are found in more than 10 % of patients with SpA before the age of 40 years in 5 % of women and 9 % in men. Most VFs are located in the thoracic region, are related to low femoral neck bonemineral density and to stiffening of the spine, and are only rarely related to trauma history. DXA is a useful alternative for diagnosing VFs. This study was supported by Hasselt University and Transnationale Universiteit Limburg, Maastricht University Medical Centre. It was also supported by an unrestricted grant from AbbVie for a non-interventional study survey. spondyloarthropathy; bone mineral density; vertebral fracture; vertebral fracture assessment |
| abstract_unstemmed |
Introduction: An increased risk of vertebral fracture (VF) is one of the extra-articular manifestations of spondyloarthropathy (SpA). The prevalence of moderate to severe VFs visualized by radiography (Rx) in patients with SpA in daily practice is unknown until imaging of the full spine is available, as most VFs do not present with clinical signs and symptoms of an acute fracture. Methods: We evaluated the prevalence of VFs (>25 % loss in height) on available Rx and dual-energy X-ray absorptiometry (DXA) images in 390 consecutive patients with SpA in daily practice. We assessed their association with disease characteristics, bone mineral density, the modified Stoke Ankylosing Spondylitis Spinal Score, and history of trauma. Results: Forty-six patients (11.8 %) had Rx VF (56.4 % men, 93.5 % in the thoracic spine), and 44.5 % had multiple VFs. Compared with patients without VF, patients with VF were older (52.2 vs. 47.3 years, p < 0.01; range 25-84 years), had lower femoral neck T-scores (-1.1 vs. -0.7; p < 0.05), and had a marginally higher modified Stoke Ankylosing Spondylitis Spinal Score (11.7 vs. 7.0; p = 0.06). Among patients with VFs, 15.2 % had a history of trauma with acute back pain (p < 0.001 vs. no VF). The reliability of DXA for diagnosing radiographic VFs was high (kappa 0.90). Conclusions: Moderate to severe VFs are found in more than 10 % of patients with SpA before the age of 40 years in 5 % of women and 9 % in men. Most VFs are located in the thoracic region, are related to low femoral neck bonemineral density and to stiffening of the spine, and are only rarely related to trauma history. DXA is a useful alternative for diagnosing VFs. This study was supported by Hasselt University and Transnationale Universiteit Limburg, Maastricht University Medical Centre. It was also supported by an unrestricted grant from AbbVie for a non-interventional study survey. spondyloarthropathy; bone mineral density; vertebral fracture; vertebral fracture assessment |
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De Winter, Liesbeth Quaden, Dana Vanhoof, Johan Vosse, Debby Van den Bergh, Joop Somers, Veerle |
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