Non-canonical NF-κB signaling in rheumatoid arthritis: Dr Jekyll and Mr Hyde?
The nuclear factor-κB (NF-κB) family of transcription factors is essential for the expression of pro-inflammatory cytokines, but can also induce regulatory pathways. NF-κB can be activated via two distinct pathways: the classical or canonical pathway, and the alternative or non-canonical pathway. It...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Noort, Ae R [verfasserIn] |
|---|
| Format: |
Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Rechteinformationen: |
Nutzungsrecht: © Noort et al.; licensee BioMed Central. 2015 |
|---|
| Schlagwörter: |
Signal Transduction - physiology Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - physiopathology |
|---|
| Übergeordnetes Werk: |
Enthalten in: Arthritis research & therapy - London : BioMed Central, 2003, 17(2015), 1, Seite 15-15 |
|---|---|
| Übergeordnetes Werk: |
volume:17 ; year:2015 ; number:1 ; pages:15-15 |
| Links: |
|---|
| DOI / URN: |
10.1186/s13075-015-0527-3 |
|---|
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OLC1961018039 |
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| 520 | |a The nuclear factor-κB (NF-κB) family of transcription factors is essential for the expression of pro-inflammatory cytokines, but can also induce regulatory pathways. NF-κB can be activated via two distinct pathways: the classical or canonical pathway, and the alternative or non-canonical pathway. It is well established that the canonical NF-κB pathway is essential both in acute inflammatory responses and in chronic inflammatory diseases, including rheumatoid arthritis (RA). Although less extensively studied, the non-canonical NF-κB pathway is not only central in lymphoid organ development and adaptive immune responses, but is also thought to play an important role in the pathogenesis of RA. Importantly, this pathway appears to have cell type-specific functions and, since many different cell types are involved in the pathogenesis of RA, it is difficult to predict the net overall contribution of the non-canonical NF-κB pathway to synovial inflammation. In this review, we describe the current understanding of non-canonical NF-κB signaling in various important cell types in the context of RA and consider the relevance to the pathogenesis of the disease. In addition, we discuss current drugs targeting this pathway, as well as future therapeutic prospects. | ||
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10.1186/s13075-015-0527-3 doi PQ20160617 (DE-627)OLC1961018039 (DE-599)GBVOLC1961018039 (PRQ)b2171-97d5d7182f6ded29180481715f98e7215438f3fb9a619cd0161092ab2f0973093 (KEY)0427448220150000017000100015noncanonicalnfbsignalinginrheumatoidarthritisdrjek DE-627 ger DE-627 rakwb eng 610 DNB Noort, Ae R verfasserin aut Non-canonical NF-κB signaling in rheumatoid arthritis: Dr Jekyll and Mr Hyde? 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The nuclear factor-κB (NF-κB) family of transcription factors is essential for the expression of pro-inflammatory cytokines, but can also induce regulatory pathways. NF-κB can be activated via two distinct pathways: the classical or canonical pathway, and the alternative or non-canonical pathway. It is well established that the canonical NF-κB pathway is essential both in acute inflammatory responses and in chronic inflammatory diseases, including rheumatoid arthritis (RA). Although less extensively studied, the non-canonical NF-κB pathway is not only central in lymphoid organ development and adaptive immune responses, but is also thought to play an important role in the pathogenesis of RA. Importantly, this pathway appears to have cell type-specific functions and, since many different cell types are involved in the pathogenesis of RA, it is difficult to predict the net overall contribution of the non-canonical NF-κB pathway to synovial inflammation. In this review, we describe the current understanding of non-canonical NF-κB signaling in various important cell types in the context of RA and consider the relevance to the pathogenesis of the disease. In addition, we discuss current drugs targeting this pathway, as well as future therapeutic prospects. Nutzungsrecht: © Noort et al.; licensee BioMed Central. 2015 Signal Transduction - physiology Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - physiopathology Arthritis, Rheumatoid - drug therapy NF-kappa B - metabolism Review Tak, Paul P oth Tas, Sander W oth Enthalten in Arthritis research & therapy London : BioMed Central, 2003 17(2015), 1, Seite 15-15 (DE-627)363765530 (DE-600)2107602-9 (DE-576)379407604 1478-6354 nnns volume:17 year:2015 number:1 pages:15-15 http://dx.doi.org/10.1186/s13075-015-0527-3 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25774937 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4308835&tool=pmcentrez&rendertype=abstract GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-NED SSG-OLC-PHA SSG-OLC-DE-84 AR 17 2015 1 15-15 |
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10.1186/s13075-015-0527-3 doi PQ20160617 (DE-627)OLC1961018039 (DE-599)GBVOLC1961018039 (PRQ)b2171-97d5d7182f6ded29180481715f98e7215438f3fb9a619cd0161092ab2f0973093 (KEY)0427448220150000017000100015noncanonicalnfbsignalinginrheumatoidarthritisdrjek DE-627 ger DE-627 rakwb eng 610 DNB Noort, Ae R verfasserin aut Non-canonical NF-κB signaling in rheumatoid arthritis: Dr Jekyll and Mr Hyde? 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The nuclear factor-κB (NF-κB) family of transcription factors is essential for the expression of pro-inflammatory cytokines, but can also induce regulatory pathways. NF-κB can be activated via two distinct pathways: the classical or canonical pathway, and the alternative or non-canonical pathway. It is well established that the canonical NF-κB pathway is essential both in acute inflammatory responses and in chronic inflammatory diseases, including rheumatoid arthritis (RA). Although less extensively studied, the non-canonical NF-κB pathway is not only central in lymphoid organ development and adaptive immune responses, but is also thought to play an important role in the pathogenesis of RA. Importantly, this pathway appears to have cell type-specific functions and, since many different cell types are involved in the pathogenesis of RA, it is difficult to predict the net overall contribution of the non-canonical NF-κB pathway to synovial inflammation. In this review, we describe the current understanding of non-canonical NF-κB signaling in various important cell types in the context of RA and consider the relevance to the pathogenesis of the disease. In addition, we discuss current drugs targeting this pathway, as well as future therapeutic prospects. Nutzungsrecht: © Noort et al.; licensee BioMed Central. 2015 Signal Transduction - physiology Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - physiopathology Arthritis, Rheumatoid - drug therapy NF-kappa B - metabolism Review Tak, Paul P oth Tas, Sander W oth Enthalten in Arthritis research & therapy London : BioMed Central, 2003 17(2015), 1, Seite 15-15 (DE-627)363765530 (DE-600)2107602-9 (DE-576)379407604 1478-6354 nnns volume:17 year:2015 number:1 pages:15-15 http://dx.doi.org/10.1186/s13075-015-0527-3 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25774937 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4308835&tool=pmcentrez&rendertype=abstract GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-NED SSG-OLC-PHA SSG-OLC-DE-84 AR 17 2015 1 15-15 |
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10.1186/s13075-015-0527-3 doi PQ20160617 (DE-627)OLC1961018039 (DE-599)GBVOLC1961018039 (PRQ)b2171-97d5d7182f6ded29180481715f98e7215438f3fb9a619cd0161092ab2f0973093 (KEY)0427448220150000017000100015noncanonicalnfbsignalinginrheumatoidarthritisdrjek DE-627 ger DE-627 rakwb eng 610 DNB Noort, Ae R verfasserin aut Non-canonical NF-κB signaling in rheumatoid arthritis: Dr Jekyll and Mr Hyde? 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The nuclear factor-κB (NF-κB) family of transcription factors is essential for the expression of pro-inflammatory cytokines, but can also induce regulatory pathways. NF-κB can be activated via two distinct pathways: the classical or canonical pathway, and the alternative or non-canonical pathway. It is well established that the canonical NF-κB pathway is essential both in acute inflammatory responses and in chronic inflammatory diseases, including rheumatoid arthritis (RA). Although less extensively studied, the non-canonical NF-κB pathway is not only central in lymphoid organ development and adaptive immune responses, but is also thought to play an important role in the pathogenesis of RA. Importantly, this pathway appears to have cell type-specific functions and, since many different cell types are involved in the pathogenesis of RA, it is difficult to predict the net overall contribution of the non-canonical NF-κB pathway to synovial inflammation. In this review, we describe the current understanding of non-canonical NF-κB signaling in various important cell types in the context of RA and consider the relevance to the pathogenesis of the disease. In addition, we discuss current drugs targeting this pathway, as well as future therapeutic prospects. Nutzungsrecht: © Noort et al.; licensee BioMed Central. 2015 Signal Transduction - physiology Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - physiopathology Arthritis, Rheumatoid - drug therapy NF-kappa B - metabolism Review Tak, Paul P oth Tas, Sander W oth Enthalten in Arthritis research & therapy London : BioMed Central, 2003 17(2015), 1, Seite 15-15 (DE-627)363765530 (DE-600)2107602-9 (DE-576)379407604 1478-6354 nnns volume:17 year:2015 number:1 pages:15-15 http://dx.doi.org/10.1186/s13075-015-0527-3 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25774937 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4308835&tool=pmcentrez&rendertype=abstract GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-NED SSG-OLC-PHA SSG-OLC-DE-84 AR 17 2015 1 15-15 |
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Non-canonical NF-κB signaling in rheumatoid arthritis: Dr Jekyll and Mr Hyde? |
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Non-canonical NF-κB signaling in rheumatoid arthritis: Dr Jekyll and Mr Hyde? |
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non-canonical nf-κb signaling in rheumatoid arthritis: dr jekyll and mr hyde? |
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Non-canonical NF-κB signaling in rheumatoid arthritis: Dr Jekyll and Mr Hyde? |
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The nuclear factor-κB (NF-κB) family of transcription factors is essential for the expression of pro-inflammatory cytokines, but can also induce regulatory pathways. NF-κB can be activated via two distinct pathways: the classical or canonical pathway, and the alternative or non-canonical pathway. It is well established that the canonical NF-κB pathway is essential both in acute inflammatory responses and in chronic inflammatory diseases, including rheumatoid arthritis (RA). Although less extensively studied, the non-canonical NF-κB pathway is not only central in lymphoid organ development and adaptive immune responses, but is also thought to play an important role in the pathogenesis of RA. Importantly, this pathway appears to have cell type-specific functions and, since many different cell types are involved in the pathogenesis of RA, it is difficult to predict the net overall contribution of the non-canonical NF-κB pathway to synovial inflammation. In this review, we describe the current understanding of non-canonical NF-κB signaling in various important cell types in the context of RA and consider the relevance to the pathogenesis of the disease. In addition, we discuss current drugs targeting this pathway, as well as future therapeutic prospects. |
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The nuclear factor-κB (NF-κB) family of transcription factors is essential for the expression of pro-inflammatory cytokines, but can also induce regulatory pathways. NF-κB can be activated via two distinct pathways: the classical or canonical pathway, and the alternative or non-canonical pathway. It is well established that the canonical NF-κB pathway is essential both in acute inflammatory responses and in chronic inflammatory diseases, including rheumatoid arthritis (RA). Although less extensively studied, the non-canonical NF-κB pathway is not only central in lymphoid organ development and adaptive immune responses, but is also thought to play an important role in the pathogenesis of RA. Importantly, this pathway appears to have cell type-specific functions and, since many different cell types are involved in the pathogenesis of RA, it is difficult to predict the net overall contribution of the non-canonical NF-κB pathway to synovial inflammation. In this review, we describe the current understanding of non-canonical NF-κB signaling in various important cell types in the context of RA and consider the relevance to the pathogenesis of the disease. In addition, we discuss current drugs targeting this pathway, as well as future therapeutic prospects. |
| abstract_unstemmed |
The nuclear factor-κB (NF-κB) family of transcription factors is essential for the expression of pro-inflammatory cytokines, but can also induce regulatory pathways. NF-κB can be activated via two distinct pathways: the classical or canonical pathway, and the alternative or non-canonical pathway. It is well established that the canonical NF-κB pathway is essential both in acute inflammatory responses and in chronic inflammatory diseases, including rheumatoid arthritis (RA). Although less extensively studied, the non-canonical NF-κB pathway is not only central in lymphoid organ development and adaptive immune responses, but is also thought to play an important role in the pathogenesis of RA. Importantly, this pathway appears to have cell type-specific functions and, since many different cell types are involved in the pathogenesis of RA, it is difficult to predict the net overall contribution of the non-canonical NF-κB pathway to synovial inflammation. In this review, we describe the current understanding of non-canonical NF-κB signaling in various important cell types in the context of RA and consider the relevance to the pathogenesis of the disease. In addition, we discuss current drugs targeting this pathway, as well as future therapeutic prospects. |
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Non-canonical NF-κB signaling in rheumatoid arthritis: Dr Jekyll and Mr Hyde? |
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http://dx.doi.org/10.1186/s13075-015-0527-3 http://www.ncbi.nlm.nih.gov/pubmed/25774937 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4308835&tool=pmcentrez&rendertype=abstract |
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