Evolution of the H9N2 influenza genotype that facilitated the genesis of the novel H7N9 virus
The emergence of human infection with a novel H7N9 influenza virus in China raises a pandemic concern. Chicken H9N2 viruses provided all six of the novel reassortant's internal genes. However, it is not fully understood how the prevalence and evolution of these H9N2 chicken viruses facilitated...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Juan Pu [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Rechteinformationen: |
Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences |
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| Übergeordnetes Werk: |
Enthalten in: Proceedings of the National Academy of Sciences of the United States of America - Washington, DC : NAS, 1877, 112(2015), 2, Seite 548-553 |
|---|---|
| Übergeordnetes Werk: |
volume:112 ; year:2015 ; number:2 ; pages:548-553 |
| Links: |
Volltext |
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| DOI / URN: |
10.1073/pnas.1422456112 |
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| Katalog-ID: |
OLC1961705605 |
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| 520 | |a The emergence of human infection with a novel H7N9 influenza virus in China raises a pandemic concern. Chicken H9N2 viruses provided all six of the novel reassortant's internal genes. However, it is not fully understood how the prevalence and evolution of these H9N2 chicken viruses facilitated the genesis of the novel H7N9 viruses. Here we show that over more than 10 y of cocirculation of multiple H9N2 genotypes, a genotype (G57) emerged that had changed antigenicity and improved adaptability in chickens. It became predominant in vaccinated farm chickens in China, caused widespread outbreaks in 2010-2013 before the H7N9 viruses emerged in humans, and finally provided all of their internal genes to the novel H7N9 viruses. The prevalence and variation of H9N2 influenza virus in farmed poultry could provide an important early warning of the emergence of novel reassortants with pandemic potential. | ||
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| 650 | 4 | |a Influenza, Human - epidemiology | |
| 650 | 4 | |a Hemagglutinin Glycoproteins, Influenza Virus - immunology | |
| 650 | 4 | |a Influenza A Virus, H9N2 Subtype - pathogenicity | |
| 650 | 4 | |a Influenza A Virus, H9N2 Subtype - genetics | |
| 650 | 4 | |a Influenza A Virus, H9N2 Subtype - immunology | |
| 650 | 4 | |a Reassortant Viruses - genetics | |
| 650 | 4 | |a Influenza, Human - virology | |
| 650 | 4 | |a Reassortant Viruses - pathogenicity | |
| 650 | 4 | |a Influenza A Virus, H7N9 Subtype - pathogenicity | |
| 650 | 4 | |a Reassortant Viruses - immunology | |
| 650 | 4 | |a Antigenic Variation - genetics | |
| 650 | 4 | |a Influenza in Birds - virology | |
| 650 | 4 | |a Hemagglutinin Glycoproteins, Influenza Virus - genetics | |
| 650 | 4 | |a Influenza in Birds - epidemiology | |
| 650 | 4 | |a Chickens - virology | |
| 650 | 4 | |a Antigens, Viral - genetics | |
| 650 | 4 | |a Influenza A Virus, H7N9 Subtype - genetics | |
| 650 | 4 | |a Influenza A Virus, H7N9 Subtype - immunology | |
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10.1073/pnas.1422456112 doi PQ20160617 (DE-627)OLC1961705605 (DE-599)GBVOLC1961705605 (PRQ)c3038-96f292c42ab590e44d76364c774c29e653c6d12942864fd8939586e542a561d73 (KEY)0583363920150000112000200548evolutionoftheh9n2influenzagenotypethatfacilitated DE-627 ger DE-627 rakwb eng 500 DNB 570 AVZ LING fid BIODIV fid Juan Pu verfasserin aut Evolution of the H9N2 influenza genotype that facilitated the genesis of the novel H7N9 virus 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The emergence of human infection with a novel H7N9 influenza virus in China raises a pandemic concern. Chicken H9N2 viruses provided all six of the novel reassortant's internal genes. However, it is not fully understood how the prevalence and evolution of these H9N2 chicken viruses facilitated the genesis of the novel H7N9 viruses. Here we show that over more than 10 y of cocirculation of multiple H9N2 genotypes, a genotype (G57) emerged that had changed antigenicity and improved adaptability in chickens. It became predominant in vaccinated farm chickens in China, caused widespread outbreaks in 2010-2013 before the H7N9 viruses emerged in humans, and finally provided all of their internal genes to the novel H7N9 viruses. The prevalence and variation of H9N2 influenza virus in farmed poultry could provide an important early warning of the emergence of novel reassortants with pandemic potential. Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences Influenza, Human - epidemiology Hemagglutinin Glycoproteins, Influenza Virus - immunology Influenza A Virus, H9N2 Subtype - pathogenicity Influenza A Virus, H9N2 Subtype - genetics Influenza A Virus, H9N2 Subtype - immunology Reassortant Viruses - genetics Influenza, Human - virology Reassortant Viruses - pathogenicity Influenza A Virus, H7N9 Subtype - pathogenicity Reassortant Viruses - immunology Antigenic Variation - genetics Influenza in Birds - virology Hemagglutinin Glycoproteins, Influenza Virus - genetics Influenza in Birds - epidemiology Chickens - virology Antigens, Viral - genetics Influenza A Virus, H7N9 Subtype - genetics Influenza A Virus, H7N9 Subtype - immunology Natural history Influenza viruses Influenza Pandemics Genotype & phenotype Poultry Evolution H9N2 genotype H7N9 chicken influenza virus Biological Sciences infectivity Shuoguo Wang oth Yanbo Yin oth Guozhong Zhang oth Robert A. Carter oth Jinliang Wang oth Guanlong Xu oth Honglei Sun oth Min Wang oth Chu Wen oth Yandi Wei oth Dongdong Wang oth Baoli Zhu oth Gordon Lemmon oth Yuannian Jiao oth Susu Duan oth Qian Wang oth Qian Du oth Meng Sun oth Jinnan Bao oth Yipeng Sun oth Jixun Zhao oth Hui Zhang oth Gang Wu oth Jinhua Liu oth Robert G. Webster oth Enthalten in Proceedings of the National Academy of Sciences of the United States of America Washington, DC : NAS, 1877 112(2015), 2, Seite 548-553 (DE-627)129505269 (DE-600)209104-5 (DE-576)014909189 0027-8424 nnns volume:112 year:2015 number:2 pages:548-553 http://dx.doi.org/10.1073/pnas.1422456112 Volltext http://www.pnas.org/content/112/2/548.abstract http://www.ncbi.nlm.nih.gov/pubmed/25548189 http://search.proquest.com/docview/1647424218 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4299237&tool=pmcentrez&rendertype=abstract GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT SSG-OPC-FOR GBV_ILN_40 GBV_ILN_59 AR 112 2015 2 548-553 |
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10.1073/pnas.1422456112 doi PQ20160617 (DE-627)OLC1961705605 (DE-599)GBVOLC1961705605 (PRQ)c3038-96f292c42ab590e44d76364c774c29e653c6d12942864fd8939586e542a561d73 (KEY)0583363920150000112000200548evolutionoftheh9n2influenzagenotypethatfacilitated DE-627 ger DE-627 rakwb eng 500 DNB 570 AVZ LING fid BIODIV fid Juan Pu verfasserin aut Evolution of the H9N2 influenza genotype that facilitated the genesis of the novel H7N9 virus 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The emergence of human infection with a novel H7N9 influenza virus in China raises a pandemic concern. Chicken H9N2 viruses provided all six of the novel reassortant's internal genes. However, it is not fully understood how the prevalence and evolution of these H9N2 chicken viruses facilitated the genesis of the novel H7N9 viruses. Here we show that over more than 10 y of cocirculation of multiple H9N2 genotypes, a genotype (G57) emerged that had changed antigenicity and improved adaptability in chickens. It became predominant in vaccinated farm chickens in China, caused widespread outbreaks in 2010-2013 before the H7N9 viruses emerged in humans, and finally provided all of their internal genes to the novel H7N9 viruses. The prevalence and variation of H9N2 influenza virus in farmed poultry could provide an important early warning of the emergence of novel reassortants with pandemic potential. Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences Influenza, Human - epidemiology Hemagglutinin Glycoproteins, Influenza Virus - immunology Influenza A Virus, H9N2 Subtype - pathogenicity Influenza A Virus, H9N2 Subtype - genetics Influenza A Virus, H9N2 Subtype - immunology Reassortant Viruses - genetics Influenza, Human - virology Reassortant Viruses - pathogenicity Influenza A Virus, H7N9 Subtype - pathogenicity Reassortant Viruses - immunology Antigenic Variation - genetics Influenza in Birds - virology Hemagglutinin Glycoproteins, Influenza Virus - genetics Influenza in Birds - epidemiology Chickens - virology Antigens, Viral - genetics Influenza A Virus, H7N9 Subtype - genetics Influenza A Virus, H7N9 Subtype - immunology Natural history Influenza viruses Influenza Pandemics Genotype & phenotype Poultry Evolution H9N2 genotype H7N9 chicken influenza virus Biological Sciences infectivity Shuoguo Wang oth Yanbo Yin oth Guozhong Zhang oth Robert A. Carter oth Jinliang Wang oth Guanlong Xu oth Honglei Sun oth Min Wang oth Chu Wen oth Yandi Wei oth Dongdong Wang oth Baoli Zhu oth Gordon Lemmon oth Yuannian Jiao oth Susu Duan oth Qian Wang oth Qian Du oth Meng Sun oth Jinnan Bao oth Yipeng Sun oth Jixun Zhao oth Hui Zhang oth Gang Wu oth Jinhua Liu oth Robert G. Webster oth Enthalten in Proceedings of the National Academy of Sciences of the United States of America Washington, DC : NAS, 1877 112(2015), 2, Seite 548-553 (DE-627)129505269 (DE-600)209104-5 (DE-576)014909189 0027-8424 nnns volume:112 year:2015 number:2 pages:548-553 http://dx.doi.org/10.1073/pnas.1422456112 Volltext http://www.pnas.org/content/112/2/548.abstract http://www.ncbi.nlm.nih.gov/pubmed/25548189 http://search.proquest.com/docview/1647424218 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4299237&tool=pmcentrez&rendertype=abstract GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT SSG-OPC-FOR GBV_ILN_40 GBV_ILN_59 AR 112 2015 2 548-553 |
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10.1073/pnas.1422456112 doi PQ20160617 (DE-627)OLC1961705605 (DE-599)GBVOLC1961705605 (PRQ)c3038-96f292c42ab590e44d76364c774c29e653c6d12942864fd8939586e542a561d73 (KEY)0583363920150000112000200548evolutionoftheh9n2influenzagenotypethatfacilitated DE-627 ger DE-627 rakwb eng 500 DNB 570 AVZ LING fid BIODIV fid Juan Pu verfasserin aut Evolution of the H9N2 influenza genotype that facilitated the genesis of the novel H7N9 virus 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The emergence of human infection with a novel H7N9 influenza virus in China raises a pandemic concern. Chicken H9N2 viruses provided all six of the novel reassortant's internal genes. However, it is not fully understood how the prevalence and evolution of these H9N2 chicken viruses facilitated the genesis of the novel H7N9 viruses. Here we show that over more than 10 y of cocirculation of multiple H9N2 genotypes, a genotype (G57) emerged that had changed antigenicity and improved adaptability in chickens. It became predominant in vaccinated farm chickens in China, caused widespread outbreaks in 2010-2013 before the H7N9 viruses emerged in humans, and finally provided all of their internal genes to the novel H7N9 viruses. The prevalence and variation of H9N2 influenza virus in farmed poultry could provide an important early warning of the emergence of novel reassortants with pandemic potential. Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences Influenza, Human - epidemiology Hemagglutinin Glycoproteins, Influenza Virus - immunology Influenza A Virus, H9N2 Subtype - pathogenicity Influenza A Virus, H9N2 Subtype - genetics Influenza A Virus, H9N2 Subtype - immunology Reassortant Viruses - genetics Influenza, Human - virology Reassortant Viruses - pathogenicity Influenza A Virus, H7N9 Subtype - pathogenicity Reassortant Viruses - immunology Antigenic Variation - genetics Influenza in Birds - virology Hemagglutinin Glycoproteins, Influenza Virus - genetics Influenza in Birds - epidemiology Chickens - virology Antigens, Viral - genetics Influenza A Virus, H7N9 Subtype - genetics Influenza A Virus, H7N9 Subtype - immunology Natural history Influenza viruses Influenza Pandemics Genotype & phenotype Poultry Evolution H9N2 genotype H7N9 chicken influenza virus Biological Sciences infectivity Shuoguo Wang oth Yanbo Yin oth Guozhong Zhang oth Robert A. Carter oth Jinliang Wang oth Guanlong Xu oth Honglei Sun oth Min Wang oth Chu Wen oth Yandi Wei oth Dongdong Wang oth Baoli Zhu oth Gordon Lemmon oth Yuannian Jiao oth Susu Duan oth Qian Wang oth Qian Du oth Meng Sun oth Jinnan Bao oth Yipeng Sun oth Jixun Zhao oth Hui Zhang oth Gang Wu oth Jinhua Liu oth Robert G. Webster oth Enthalten in Proceedings of the National Academy of Sciences of the United States of America Washington, DC : NAS, 1877 112(2015), 2, Seite 548-553 (DE-627)129505269 (DE-600)209104-5 (DE-576)014909189 0027-8424 nnns volume:112 year:2015 number:2 pages:548-553 http://dx.doi.org/10.1073/pnas.1422456112 Volltext http://www.pnas.org/content/112/2/548.abstract http://www.ncbi.nlm.nih.gov/pubmed/25548189 http://search.proquest.com/docview/1647424218 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4299237&tool=pmcentrez&rendertype=abstract GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT SSG-OPC-FOR GBV_ILN_40 GBV_ILN_59 AR 112 2015 2 548-553 |
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10.1073/pnas.1422456112 doi PQ20160617 (DE-627)OLC1961705605 (DE-599)GBVOLC1961705605 (PRQ)c3038-96f292c42ab590e44d76364c774c29e653c6d12942864fd8939586e542a561d73 (KEY)0583363920150000112000200548evolutionoftheh9n2influenzagenotypethatfacilitated DE-627 ger DE-627 rakwb eng 500 DNB 570 AVZ LING fid BIODIV fid Juan Pu verfasserin aut Evolution of the H9N2 influenza genotype that facilitated the genesis of the novel H7N9 virus 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The emergence of human infection with a novel H7N9 influenza virus in China raises a pandemic concern. Chicken H9N2 viruses provided all six of the novel reassortant's internal genes. However, it is not fully understood how the prevalence and evolution of these H9N2 chicken viruses facilitated the genesis of the novel H7N9 viruses. Here we show that over more than 10 y of cocirculation of multiple H9N2 genotypes, a genotype (G57) emerged that had changed antigenicity and improved adaptability in chickens. It became predominant in vaccinated farm chickens in China, caused widespread outbreaks in 2010-2013 before the H7N9 viruses emerged in humans, and finally provided all of their internal genes to the novel H7N9 viruses. The prevalence and variation of H9N2 influenza virus in farmed poultry could provide an important early warning of the emergence of novel reassortants with pandemic potential. Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences Influenza, Human - epidemiology Hemagglutinin Glycoproteins, Influenza Virus - immunology Influenza A Virus, H9N2 Subtype - pathogenicity Influenza A Virus, H9N2 Subtype - genetics Influenza A Virus, H9N2 Subtype - immunology Reassortant Viruses - genetics Influenza, Human - virology Reassortant Viruses - pathogenicity Influenza A Virus, H7N9 Subtype - pathogenicity Reassortant Viruses - immunology Antigenic Variation - genetics Influenza in Birds - virology Hemagglutinin Glycoproteins, Influenza Virus - genetics Influenza in Birds - epidemiology Chickens - virology Antigens, Viral - genetics Influenza A Virus, H7N9 Subtype - genetics Influenza A Virus, H7N9 Subtype - immunology Natural history Influenza viruses Influenza Pandemics Genotype & phenotype Poultry Evolution H9N2 genotype H7N9 chicken influenza virus Biological Sciences infectivity Shuoguo Wang oth Yanbo Yin oth Guozhong Zhang oth Robert A. Carter oth Jinliang Wang oth Guanlong Xu oth Honglei Sun oth Min Wang oth Chu Wen oth Yandi Wei oth Dongdong Wang oth Baoli Zhu oth Gordon Lemmon oth Yuannian Jiao oth Susu Duan oth Qian Wang oth Qian Du oth Meng Sun oth Jinnan Bao oth Yipeng Sun oth Jixun Zhao oth Hui Zhang oth Gang Wu oth Jinhua Liu oth Robert G. Webster oth Enthalten in Proceedings of the National Academy of Sciences of the United States of America Washington, DC : NAS, 1877 112(2015), 2, Seite 548-553 (DE-627)129505269 (DE-600)209104-5 (DE-576)014909189 0027-8424 nnns volume:112 year:2015 number:2 pages:548-553 http://dx.doi.org/10.1073/pnas.1422456112 Volltext http://www.pnas.org/content/112/2/548.abstract http://www.ncbi.nlm.nih.gov/pubmed/25548189 http://search.proquest.com/docview/1647424218 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4299237&tool=pmcentrez&rendertype=abstract GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT SSG-OPC-FOR GBV_ILN_40 GBV_ILN_59 AR 112 2015 2 548-553 |
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10.1073/pnas.1422456112 doi PQ20160617 (DE-627)OLC1961705605 (DE-599)GBVOLC1961705605 (PRQ)c3038-96f292c42ab590e44d76364c774c29e653c6d12942864fd8939586e542a561d73 (KEY)0583363920150000112000200548evolutionoftheh9n2influenzagenotypethatfacilitated DE-627 ger DE-627 rakwb eng 500 DNB 570 AVZ LING fid BIODIV fid Juan Pu verfasserin aut Evolution of the H9N2 influenza genotype that facilitated the genesis of the novel H7N9 virus 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The emergence of human infection with a novel H7N9 influenza virus in China raises a pandemic concern. Chicken H9N2 viruses provided all six of the novel reassortant's internal genes. However, it is not fully understood how the prevalence and evolution of these H9N2 chicken viruses facilitated the genesis of the novel H7N9 viruses. Here we show that over more than 10 y of cocirculation of multiple H9N2 genotypes, a genotype (G57) emerged that had changed antigenicity and improved adaptability in chickens. It became predominant in vaccinated farm chickens in China, caused widespread outbreaks in 2010-2013 before the H7N9 viruses emerged in humans, and finally provided all of their internal genes to the novel H7N9 viruses. The prevalence and variation of H9N2 influenza virus in farmed poultry could provide an important early warning of the emergence of novel reassortants with pandemic potential. Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences Influenza, Human - epidemiology Hemagglutinin Glycoproteins, Influenza Virus - immunology Influenza A Virus, H9N2 Subtype - pathogenicity Influenza A Virus, H9N2 Subtype - genetics Influenza A Virus, H9N2 Subtype - immunology Reassortant Viruses - genetics Influenza, Human - virology Reassortant Viruses - pathogenicity Influenza A Virus, H7N9 Subtype - pathogenicity Reassortant Viruses - immunology Antigenic Variation - genetics Influenza in Birds - virology Hemagglutinin Glycoproteins, Influenza Virus - genetics Influenza in Birds - epidemiology Chickens - virology Antigens, Viral - genetics Influenza A Virus, H7N9 Subtype - genetics Influenza A Virus, H7N9 Subtype - immunology Natural history Influenza viruses Influenza Pandemics Genotype & phenotype Poultry Evolution H9N2 genotype H7N9 chicken influenza virus Biological Sciences infectivity Shuoguo Wang oth Yanbo Yin oth Guozhong Zhang oth Robert A. Carter oth Jinliang Wang oth Guanlong Xu oth Honglei Sun oth Min Wang oth Chu Wen oth Yandi Wei oth Dongdong Wang oth Baoli Zhu oth Gordon Lemmon oth Yuannian Jiao oth Susu Duan oth Qian Wang oth Qian Du oth Meng Sun oth Jinnan Bao oth Yipeng Sun oth Jixun Zhao oth Hui Zhang oth Gang Wu oth Jinhua Liu oth Robert G. Webster oth Enthalten in Proceedings of the National Academy of Sciences of the United States of America Washington, DC : NAS, 1877 112(2015), 2, Seite 548-553 (DE-627)129505269 (DE-600)209104-5 (DE-576)014909189 0027-8424 nnns volume:112 year:2015 number:2 pages:548-553 http://dx.doi.org/10.1073/pnas.1422456112 Volltext http://www.pnas.org/content/112/2/548.abstract http://www.ncbi.nlm.nih.gov/pubmed/25548189 http://search.proquest.com/docview/1647424218 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4299237&tool=pmcentrez&rendertype=abstract GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT SSG-OPC-FOR GBV_ILN_40 GBV_ILN_59 AR 112 2015 2 548-553 |
| language |
English |
| source |
Enthalten in Proceedings of the National Academy of Sciences of the United States of America 112(2015), 2, Seite 548-553 volume:112 year:2015 number:2 pages:548-553 |
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evolution of the h9n2 influenza genotype that facilitated the genesis of the novel h7n9 virus |
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Evolution of the H9N2 influenza genotype that facilitated the genesis of the novel H7N9 virus |
| abstract |
The emergence of human infection with a novel H7N9 influenza virus in China raises a pandemic concern. Chicken H9N2 viruses provided all six of the novel reassortant's internal genes. However, it is not fully understood how the prevalence and evolution of these H9N2 chicken viruses facilitated the genesis of the novel H7N9 viruses. Here we show that over more than 10 y of cocirculation of multiple H9N2 genotypes, a genotype (G57) emerged that had changed antigenicity and improved adaptability in chickens. It became predominant in vaccinated farm chickens in China, caused widespread outbreaks in 2010-2013 before the H7N9 viruses emerged in humans, and finally provided all of their internal genes to the novel H7N9 viruses. The prevalence and variation of H9N2 influenza virus in farmed poultry could provide an important early warning of the emergence of novel reassortants with pandemic potential. |
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The emergence of human infection with a novel H7N9 influenza virus in China raises a pandemic concern. Chicken H9N2 viruses provided all six of the novel reassortant's internal genes. However, it is not fully understood how the prevalence and evolution of these H9N2 chicken viruses facilitated the genesis of the novel H7N9 viruses. Here we show that over more than 10 y of cocirculation of multiple H9N2 genotypes, a genotype (G57) emerged that had changed antigenicity and improved adaptability in chickens. It became predominant in vaccinated farm chickens in China, caused widespread outbreaks in 2010-2013 before the H7N9 viruses emerged in humans, and finally provided all of their internal genes to the novel H7N9 viruses. The prevalence and variation of H9N2 influenza virus in farmed poultry could provide an important early warning of the emergence of novel reassortants with pandemic potential. |
| abstract_unstemmed |
The emergence of human infection with a novel H7N9 influenza virus in China raises a pandemic concern. Chicken H9N2 viruses provided all six of the novel reassortant's internal genes. However, it is not fully understood how the prevalence and evolution of these H9N2 chicken viruses facilitated the genesis of the novel H7N9 viruses. Here we show that over more than 10 y of cocirculation of multiple H9N2 genotypes, a genotype (G57) emerged that had changed antigenicity and improved adaptability in chickens. It became predominant in vaccinated farm chickens in China, caused widespread outbreaks in 2010-2013 before the H7N9 viruses emerged in humans, and finally provided all of their internal genes to the novel H7N9 viruses. The prevalence and variation of H9N2 influenza virus in farmed poultry could provide an important early warning of the emergence of novel reassortants with pandemic potential. |
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Evolution of the H9N2 influenza genotype that facilitated the genesis of the novel H7N9 virus |
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http://dx.doi.org/10.1073/pnas.1422456112 http://www.pnas.org/content/112/2/548.abstract http://www.ncbi.nlm.nih.gov/pubmed/25548189 http://search.proquest.com/docview/1647424218 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4299237&tool=pmcentrez&rendertype=abstract |
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Shuoguo Wang Yanbo Yin Guozhong Zhang Robert A. Carter Jinliang Wang Guanlong Xu Honglei Sun Min Wang Chu Wen Yandi Wei Dongdong Wang Baoli Zhu Gordon Lemmon Yuannian Jiao Susu Duan Qian Wang Qian Du Meng Sun Jinnan Bao Yipeng Sun Jixun Zhao Hui Zhang Gang Wu Jinhua Liu Robert G. Webster |
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Shuoguo Wang Yanbo Yin Guozhong Zhang Robert A. Carter Jinliang Wang Guanlong Xu Honglei Sun Min Wang Chu Wen Yandi Wei Dongdong Wang Baoli Zhu Gordon Lemmon Yuannian Jiao Susu Duan Qian Wang Qian Du Meng Sun Jinnan Bao Yipeng Sun Jixun Zhao Hui Zhang Gang Wu Jinhua Liu Robert G. Webster |
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10.1073/pnas.1422456112 |
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2024-07-04T01:56:20.389Z |
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