Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells

Alterations of mitochondrial metabolism and genomic instability have been implicated in tumorigenesis in multiple tissues. High-grade glioma (HGG), one of the most lethal human neoplasms, displays genetic modifications of Krebs cycle components as well as electron transport chain (ETC) alterations....
Ausführliche Beschreibung

Gespeichert in:
Autor*in:

Stefano Bartesaghi [verfasserIn]

Vincenzo Graziano

Sara Galavotti

Nick V. Henriquez

Joanne Betts

Jayeta Saxena

Deli A

Anna Karlsson

L. Miguel Martins

Melania Capasso

Pierluigi Nicotera

Sebastian Brandner

Vincenzo De Laurenzi

Paolo Salomoni

Format:

Artikel

Sprache:

Englisch

Erschienen:

2015

Rechteinformationen:

Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences

Schlagwörter:

Neural Stem Cells - metabolism

Glioma - metabolism

Neural Stem Cells - pathology

Tumor Suppressor Protein p53 - genetics

Cell Transformation, Neoplastic - metabolism

Citric Acid Cycle - genetics

Electron Transport Chain Complex Proteins - genetics

Brain Neoplasms - genetics

Glioma - genetics

Cell Transformation, Neoplastic - genetics

Electron Transport Chain Complex Proteins - metabolism

Brain Neoplasms - pathology

Glioma - pathology

Glycolysis - genetics

Cell Transformation, Neoplastic - pathology

Brain Neoplasms - metabolism

Tumor Suppressor Protein p53 - metabolism

Research

Reactive oxygen species

Gene mutations

Analysis

Stem cell research

Genetics

Mitochondrial DNA

Stem cells

Tumorigenesis

Tumors

Rodents

Metabolism

Genomics

mitochondrial metabolism

brain cancer

p53

Biological Sciences

Übergeordnetes Werk:

Enthalten in: Proceedings of the National Academy of Sciences of the United States of America - Washington, DC : NAS, 1877, 112(2015), 4, Seite 1059-1064

Übergeordnetes Werk:

volume:112 ; year:2015 ; number:4 ; pages:1059-1064

Links:

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DOI / URN:

10.1073/pnas.1413165112

Katalog-ID:

OLC1961708310

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