Opioid receptor delta as a global modulator of skin differentiation and barrier function repair

The aims of this study were to confirm the properties of selective agonist peptide (Rubixyl) contained in the spinach towards opioid receptor delta. In fact, agonist properties of both spinach peptides (Rubiscolin-5 and Rubixyl) towards opioid receptor delta were demonstrated by Zang et al., but their effects on the other opioid receptors were not studied [1]. We also studied the expression of opioid receptor delta in epidermis under normal and stress condition (inflammatory) and its role in epidermis homeostasis under stress condition in vitro and in vivo. Agonist properties studies were performed using functional agonist cellular model containing human opioid receptors. Opioid receptor delta expression and epidermis homeostasis were studied on human reconstructed epidermis under normal and stress conditions (inflammatory stress) using gene expression (RT-qPCR) and protein expression analysis (immunohistological analysis). Skin repair properties of opioid receptor delta agonist were based on the following parameters TEWL (trans epidermal water loss, hydration and wrinkle depth at periocular and perilabial area) on human volunteers having either intrinsic ageing (more than 40 years old and non-smoker group) and both intrinsic ageing and extrinsic ageing (more than 40 years old and smoker group). We have demonstrated that the Rubixyl peptide is a specific agonist of opioid receptor delta. We have demonstrated that opioid receptor delta expression is modulated under inflammatory condition. The agonist Rubixyl was able to block the depletion of opioid receptor delta seen under inflammatory condition in reconstructed human epidermis. Inflammatory conditions lead to the unbalanced gene and protein expressions of markers involved in epidermis integrity and barrier function properties. The treatment of human reconstructed epidermis with the agonist Rubixyl leads to the normalization of unbalanced gene and protein expressions. In vivo study has confirmed the efficiency of the agonist Rubixyl to repair damaged skin by decreasing TEWL, increasing hydration and decreasing wrinkle depth at the periocular and perilabial area. In this research, we have demonstrated in vitro (on inflamed reconstructed human epidermis, RHE) and in vivo (on human aged volunteers) that activation by natural agonist peptide of opioid receptor delta reduces the skin inflammation thus leading to improvement in epidermis differentiation and skin barrier properties. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Chajra, H [verfasserIn] Amstutz, B Schweikert, K Auriol, D Redziniak, G Lefèvre, F

Format:	Artikel
Sprache:	Englisch

Erschienen:	2015

Rechteinformationen:	Nutzungsrecht: © 2015 Society of Cosmetic Scientists and the Société Française de Cosmétologie © 2015 Society of Cosmetic Scientists and the Société Française de Cosmétologie.

Schlagwörter:	sensitive skin/inflammation/Allergy skin physiology/structure skin repair/skin differentiation

Übergeordnetes Werk:	Enthalten in: International journal of cosmetic science - Oxford : Blackwell, 1979, 37(2015), 4, Seite 386-394
Übergeordnetes Werk:	volume:37 ; year:2015 ; number:4 ; pages:386-394

Links:	Volltext Link aufrufen Link aufrufen Link aufrufen

DOI / URN:	10.1111/ics.12207

Katalog-ID:	OLC1962247031

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allfields	10.1111/ics.12207 doi PQ20160617 (DE-627)OLC1962247031 (DE-599)GBVOLC1962247031 (PRQ)c2097-368663ae5bce3534887e36488546e49b8ec550dcdf197accfc1be949113c423e0 (KEY)0001202520150000037000400386opioidreceptordeltaasaglobalmodulatorofskindiffere DE-627 ger DE-627 rakwb eng 610 DNB 58.00 bkl Chajra, H verfasserin aut Opioid receptor delta as a global modulator of skin differentiation and barrier function repair 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The aims of this study were to confirm the properties of selective agonist peptide (Rubixyl) contained in the spinach towards opioid receptor delta. In fact, agonist properties of both spinach peptides (Rubiscolin-5 and Rubixyl) towards opioid receptor delta were demonstrated by Zang et al., but their effects on the other opioid receptors were not studied [1]. We also studied the expression of opioid receptor delta in epidermis under normal and stress condition (inflammatory) and its role in epidermis homeostasis under stress condition in vitro and in vivo. Agonist properties studies were performed using functional agonist cellular model containing human opioid receptors. Opioid receptor delta expression and epidermis homeostasis were studied on human reconstructed epidermis under normal and stress conditions (inflammatory stress) using gene expression (RT-qPCR) and protein expression analysis (immunohistological analysis). Skin repair properties of opioid receptor delta agonist were based on the following parameters TEWL (trans epidermal water loss, hydration and wrinkle depth at periocular and perilabial area) on human volunteers having either intrinsic ageing (more than 40 years old and non-smoker group) and both intrinsic ageing and extrinsic ageing (more than 40 years old and smoker group). We have demonstrated that the Rubixyl peptide is a specific agonist of opioid receptor delta. We have demonstrated that opioid receptor delta expression is modulated under inflammatory condition. The agonist Rubixyl was able to block the depletion of opioid receptor delta seen under inflammatory condition in reconstructed human epidermis. Inflammatory conditions lead to the unbalanced gene and protein expressions of markers involved in epidermis integrity and barrier function properties. The treatment of human reconstructed epidermis with the agonist Rubixyl leads to the normalization of unbalanced gene and protein expressions. In vivo study has confirmed the efficiency of the agonist Rubixyl to repair damaged skin by decreasing TEWL, increasing hydration and decreasing wrinkle depth at the periocular and perilabial area. In this research, we have demonstrated in vitro (on inflamed reconstructed human epidermis, RHE) and in vivo (on human aged volunteers) that activation by natural agonist peptide of opioid receptor delta reduces the skin inflammation thus leading to improvement in epidermis differentiation and skin barrier properties. Nutzungsrecht: © 2015 Society of Cosmetic Scientists and the Société Française de Cosmétologie © 2015 Society of Cosmetic Scientists and the Société Française de Cosmétologie. sensitive skin/inflammation/Allergy skin physiology/structure skin repair/skin differentiation Amstutz, B oth Schweikert, K oth Auriol, D oth Redziniak, G oth Lefèvre, F oth Enthalten in International journal of cosmetic science Oxford : Blackwell, 1979 37(2015), 4, Seite 386-394 (DE-627)129454028 (DE-600)198917-0 (DE-576)107470454 0142-5463 nnns volume:37 year:2015 number:4 pages:386-394 http://dx.doi.org/10.1111/ics.12207 Volltext http://onlinelibrary.wiley.com/doi/10.1111/ics.12207/abstract http://www.ncbi.nlm.nih.gov/pubmed/25660727 http://search.proquest.com/docview/1693621181 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_252 GBV_ILN_4012 58.00 AVZ AR 37 2015 4 386-394
spelling	10.1111/ics.12207 doi PQ20160617 (DE-627)OLC1962247031 (DE-599)GBVOLC1962247031 (PRQ)c2097-368663ae5bce3534887e36488546e49b8ec550dcdf197accfc1be949113c423e0 (KEY)0001202520150000037000400386opioidreceptordeltaasaglobalmodulatorofskindiffere DE-627 ger DE-627 rakwb eng 610 DNB 58.00 bkl Chajra, H verfasserin aut Opioid receptor delta as a global modulator of skin differentiation and barrier function repair 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The aims of this study were to confirm the properties of selective agonist peptide (Rubixyl) contained in the spinach towards opioid receptor delta. In fact, agonist properties of both spinach peptides (Rubiscolin-5 and Rubixyl) towards opioid receptor delta were demonstrated by Zang et al., but their effects on the other opioid receptors were not studied [1]. We also studied the expression of opioid receptor delta in epidermis under normal and stress condition (inflammatory) and its role in epidermis homeostasis under stress condition in vitro and in vivo. Agonist properties studies were performed using functional agonist cellular model containing human opioid receptors. Opioid receptor delta expression and epidermis homeostasis were studied on human reconstructed epidermis under normal and stress conditions (inflammatory stress) using gene expression (RT-qPCR) and protein expression analysis (immunohistological analysis). Skin repair properties of opioid receptor delta agonist were based on the following parameters TEWL (trans epidermal water loss, hydration and wrinkle depth at periocular and perilabial area) on human volunteers having either intrinsic ageing (more than 40 years old and non-smoker group) and both intrinsic ageing and extrinsic ageing (more than 40 years old and smoker group). We have demonstrated that the Rubixyl peptide is a specific agonist of opioid receptor delta. We have demonstrated that opioid receptor delta expression is modulated under inflammatory condition. The agonist Rubixyl was able to block the depletion of opioid receptor delta seen under inflammatory condition in reconstructed human epidermis. Inflammatory conditions lead to the unbalanced gene and protein expressions of markers involved in epidermis integrity and barrier function properties. The treatment of human reconstructed epidermis with the agonist Rubixyl leads to the normalization of unbalanced gene and protein expressions. In vivo study has confirmed the efficiency of the agonist Rubixyl to repair damaged skin by decreasing TEWL, increasing hydration and decreasing wrinkle depth at the periocular and perilabial area. In this research, we have demonstrated in vitro (on inflamed reconstructed human epidermis, RHE) and in vivo (on human aged volunteers) that activation by natural agonist peptide of opioid receptor delta reduces the skin inflammation thus leading to improvement in epidermis differentiation and skin barrier properties. Nutzungsrecht: © 2015 Society of Cosmetic Scientists and the Société Française de Cosmétologie © 2015 Society of Cosmetic Scientists and the Société Française de Cosmétologie. sensitive skin/inflammation/Allergy skin physiology/structure skin repair/skin differentiation Amstutz, B oth Schweikert, K oth Auriol, D oth Redziniak, G oth Lefèvre, F oth Enthalten in International journal of cosmetic science Oxford : Blackwell, 1979 37(2015), 4, Seite 386-394 (DE-627)129454028 (DE-600)198917-0 (DE-576)107470454 0142-5463 nnns volume:37 year:2015 number:4 pages:386-394 http://dx.doi.org/10.1111/ics.12207 Volltext http://onlinelibrary.wiley.com/doi/10.1111/ics.12207/abstract http://www.ncbi.nlm.nih.gov/pubmed/25660727 http://search.proquest.com/docview/1693621181 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_252 GBV_ILN_4012 58.00 AVZ AR 37 2015 4 386-394
allfields_unstemmed	10.1111/ics.12207 doi PQ20160617 (DE-627)OLC1962247031 (DE-599)GBVOLC1962247031 (PRQ)c2097-368663ae5bce3534887e36488546e49b8ec550dcdf197accfc1be949113c423e0 (KEY)0001202520150000037000400386opioidreceptordeltaasaglobalmodulatorofskindiffere DE-627 ger DE-627 rakwb eng 610 DNB 58.00 bkl Chajra, H verfasserin aut Opioid receptor delta as a global modulator of skin differentiation and barrier function repair 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The aims of this study were to confirm the properties of selective agonist peptide (Rubixyl) contained in the spinach towards opioid receptor delta. In fact, agonist properties of both spinach peptides (Rubiscolin-5 and Rubixyl) towards opioid receptor delta were demonstrated by Zang et al., but their effects on the other opioid receptors were not studied [1]. We also studied the expression of opioid receptor delta in epidermis under normal and stress condition (inflammatory) and its role in epidermis homeostasis under stress condition in vitro and in vivo. Agonist properties studies were performed using functional agonist cellular model containing human opioid receptors. Opioid receptor delta expression and epidermis homeostasis were studied on human reconstructed epidermis under normal and stress conditions (inflammatory stress) using gene expression (RT-qPCR) and protein expression analysis (immunohistological analysis). Skin repair properties of opioid receptor delta agonist were based on the following parameters TEWL (trans epidermal water loss, hydration and wrinkle depth at periocular and perilabial area) on human volunteers having either intrinsic ageing (more than 40 years old and non-smoker group) and both intrinsic ageing and extrinsic ageing (more than 40 years old and smoker group). We have demonstrated that the Rubixyl peptide is a specific agonist of opioid receptor delta. We have demonstrated that opioid receptor delta expression is modulated under inflammatory condition. The agonist Rubixyl was able to block the depletion of opioid receptor delta seen under inflammatory condition in reconstructed human epidermis. Inflammatory conditions lead to the unbalanced gene and protein expressions of markers involved in epidermis integrity and barrier function properties. The treatment of human reconstructed epidermis with the agonist Rubixyl leads to the normalization of unbalanced gene and protein expressions. In vivo study has confirmed the efficiency of the agonist Rubixyl to repair damaged skin by decreasing TEWL, increasing hydration and decreasing wrinkle depth at the periocular and perilabial area. In this research, we have demonstrated in vitro (on inflamed reconstructed human epidermis, RHE) and in vivo (on human aged volunteers) that activation by natural agonist peptide of opioid receptor delta reduces the skin inflammation thus leading to improvement in epidermis differentiation and skin barrier properties. Nutzungsrecht: © 2015 Society of Cosmetic Scientists and the Société Française de Cosmétologie © 2015 Society of Cosmetic Scientists and the Société Française de Cosmétologie. sensitive skin/inflammation/Allergy skin physiology/structure skin repair/skin differentiation Amstutz, B oth Schweikert, K oth Auriol, D oth Redziniak, G oth Lefèvre, F oth Enthalten in International journal of cosmetic science Oxford : Blackwell, 1979 37(2015), 4, Seite 386-394 (DE-627)129454028 (DE-600)198917-0 (DE-576)107470454 0142-5463 nnns volume:37 year:2015 number:4 pages:386-394 http://dx.doi.org/10.1111/ics.12207 Volltext http://onlinelibrary.wiley.com/doi/10.1111/ics.12207/abstract http://www.ncbi.nlm.nih.gov/pubmed/25660727 http://search.proquest.com/docview/1693621181 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_252 GBV_ILN_4012 58.00 AVZ AR 37 2015 4 386-394
allfieldsGer	10.1111/ics.12207 doi PQ20160617 (DE-627)OLC1962247031 (DE-599)GBVOLC1962247031 (PRQ)c2097-368663ae5bce3534887e36488546e49b8ec550dcdf197accfc1be949113c423e0 (KEY)0001202520150000037000400386opioidreceptordeltaasaglobalmodulatorofskindiffere DE-627 ger DE-627 rakwb eng 610 DNB 58.00 bkl Chajra, H verfasserin aut Opioid receptor delta as a global modulator of skin differentiation and barrier function repair 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The aims of this study were to confirm the properties of selective agonist peptide (Rubixyl) contained in the spinach towards opioid receptor delta. In fact, agonist properties of both spinach peptides (Rubiscolin-5 and Rubixyl) towards opioid receptor delta were demonstrated by Zang et al., but their effects on the other opioid receptors were not studied [1]. We also studied the expression of opioid receptor delta in epidermis under normal and stress condition (inflammatory) and its role in epidermis homeostasis under stress condition in vitro and in vivo. Agonist properties studies were performed using functional agonist cellular model containing human opioid receptors. Opioid receptor delta expression and epidermis homeostasis were studied on human reconstructed epidermis under normal and stress conditions (inflammatory stress) using gene expression (RT-qPCR) and protein expression analysis (immunohistological analysis). Skin repair properties of opioid receptor delta agonist were based on the following parameters TEWL (trans epidermal water loss, hydration and wrinkle depth at periocular and perilabial area) on human volunteers having either intrinsic ageing (more than 40 years old and non-smoker group) and both intrinsic ageing and extrinsic ageing (more than 40 years old and smoker group). We have demonstrated that the Rubixyl peptide is a specific agonist of opioid receptor delta. We have demonstrated that opioid receptor delta expression is modulated under inflammatory condition. The agonist Rubixyl was able to block the depletion of opioid receptor delta seen under inflammatory condition in reconstructed human epidermis. Inflammatory conditions lead to the unbalanced gene and protein expressions of markers involved in epidermis integrity and barrier function properties. The treatment of human reconstructed epidermis with the agonist Rubixyl leads to the normalization of unbalanced gene and protein expressions. In vivo study has confirmed the efficiency of the agonist Rubixyl to repair damaged skin by decreasing TEWL, increasing hydration and decreasing wrinkle depth at the periocular and perilabial area. In this research, we have demonstrated in vitro (on inflamed reconstructed human epidermis, RHE) and in vivo (on human aged volunteers) that activation by natural agonist peptide of opioid receptor delta reduces the skin inflammation thus leading to improvement in epidermis differentiation and skin barrier properties. Nutzungsrecht: © 2015 Society of Cosmetic Scientists and the Société Française de Cosmétologie © 2015 Society of Cosmetic Scientists and the Société Française de Cosmétologie. sensitive skin/inflammation/Allergy skin physiology/structure skin repair/skin differentiation Amstutz, B oth Schweikert, K oth Auriol, D oth Redziniak, G oth Lefèvre, F oth Enthalten in International journal of cosmetic science Oxford : Blackwell, 1979 37(2015), 4, Seite 386-394 (DE-627)129454028 (DE-600)198917-0 (DE-576)107470454 0142-5463 nnns volume:37 year:2015 number:4 pages:386-394 http://dx.doi.org/10.1111/ics.12207 Volltext http://onlinelibrary.wiley.com/doi/10.1111/ics.12207/abstract http://www.ncbi.nlm.nih.gov/pubmed/25660727 http://search.proquest.com/docview/1693621181 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_252 GBV_ILN_4012 58.00 AVZ AR 37 2015 4 386-394
allfieldsSound	10.1111/ics.12207 doi PQ20160617 (DE-627)OLC1962247031 (DE-599)GBVOLC1962247031 (PRQ)c2097-368663ae5bce3534887e36488546e49b8ec550dcdf197accfc1be949113c423e0 (KEY)0001202520150000037000400386opioidreceptordeltaasaglobalmodulatorofskindiffere DE-627 ger DE-627 rakwb eng 610 DNB 58.00 bkl Chajra, H verfasserin aut Opioid receptor delta as a global modulator of skin differentiation and barrier function repair 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The aims of this study were to confirm the properties of selective agonist peptide (Rubixyl) contained in the spinach towards opioid receptor delta. In fact, agonist properties of both spinach peptides (Rubiscolin-5 and Rubixyl) towards opioid receptor delta were demonstrated by Zang et al., but their effects on the other opioid receptors were not studied [1]. We also studied the expression of opioid receptor delta in epidermis under normal and stress condition (inflammatory) and its role in epidermis homeostasis under stress condition in vitro and in vivo. Agonist properties studies were performed using functional agonist cellular model containing human opioid receptors. Opioid receptor delta expression and epidermis homeostasis were studied on human reconstructed epidermis under normal and stress conditions (inflammatory stress) using gene expression (RT-qPCR) and protein expression analysis (immunohistological analysis). Skin repair properties of opioid receptor delta agonist were based on the following parameters TEWL (trans epidermal water loss, hydration and wrinkle depth at periocular and perilabial area) on human volunteers having either intrinsic ageing (more than 40 years old and non-smoker group) and both intrinsic ageing and extrinsic ageing (more than 40 years old and smoker group). We have demonstrated that the Rubixyl peptide is a specific agonist of opioid receptor delta. We have demonstrated that opioid receptor delta expression is modulated under inflammatory condition. The agonist Rubixyl was able to block the depletion of opioid receptor delta seen under inflammatory condition in reconstructed human epidermis. Inflammatory conditions lead to the unbalanced gene and protein expressions of markers involved in epidermis integrity and barrier function properties. The treatment of human reconstructed epidermis with the agonist Rubixyl leads to the normalization of unbalanced gene and protein expressions. In vivo study has confirmed the efficiency of the agonist Rubixyl to repair damaged skin by decreasing TEWL, increasing hydration and decreasing wrinkle depth at the periocular and perilabial area. In this research, we have demonstrated in vitro (on inflamed reconstructed human epidermis, RHE) and in vivo (on human aged volunteers) that activation by natural agonist peptide of opioid receptor delta reduces the skin inflammation thus leading to improvement in epidermis differentiation and skin barrier properties. Nutzungsrecht: © 2015 Society of Cosmetic Scientists and the Société Française de Cosmétologie © 2015 Society of Cosmetic Scientists and the Société Française de Cosmétologie. sensitive skin/inflammation/Allergy skin physiology/structure skin repair/skin differentiation Amstutz, B oth Schweikert, K oth Auriol, D oth Redziniak, G oth Lefèvre, F oth Enthalten in International journal of cosmetic science Oxford : Blackwell, 1979 37(2015), 4, Seite 386-394 (DE-627)129454028 (DE-600)198917-0 (DE-576)107470454 0142-5463 nnns volume:37 year:2015 number:4 pages:386-394 http://dx.doi.org/10.1111/ics.12207 Volltext http://onlinelibrary.wiley.com/doi/10.1111/ics.12207/abstract http://www.ncbi.nlm.nih.gov/pubmed/25660727 http://search.proquest.com/docview/1693621181 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_252 GBV_ILN_4012 58.00 AVZ AR 37 2015 4 386-394
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author	Chajra, H
spellingShingle	Chajra, H ddc 610 bkl 58.00 misc sensitive skin/inflammation/Allergy misc skin physiology/structure misc skin repair/skin differentiation Opioid receptor delta as a global modulator of skin differentiation and barrier function repair
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topic_title	610 DNB 58.00 bkl Opioid receptor delta as a global modulator of skin differentiation and barrier function repair sensitive skin/inflammation/Allergy skin physiology/structure skin repair/skin differentiation
topic	ddc 610 bkl 58.00 misc sensitive skin/inflammation/Allergy misc skin physiology/structure misc skin repair/skin differentiation
topic_unstemmed	ddc 610 bkl 58.00 misc sensitive skin/inflammation/Allergy misc skin physiology/structure misc skin repair/skin differentiation
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title	Opioid receptor delta as a global modulator of skin differentiation and barrier function repair
ctrlnum	(DE-627)OLC1962247031 (DE-599)GBVOLC1962247031 (PRQ)c2097-368663ae5bce3534887e36488546e49b8ec550dcdf197accfc1be949113c423e0 (KEY)0001202520150000037000400386opioidreceptordeltaasaglobalmodulatorofskindiffere
title_full	Opioid receptor delta as a global modulator of skin differentiation and barrier function repair
author_sort	Chajra, H
journal	International journal of cosmetic science
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title_sort	opioid receptor delta as a global modulator of skin differentiation and barrier function repair
title_auth	Opioid receptor delta as a global modulator of skin differentiation and barrier function repair
abstract	The aims of this study were to confirm the properties of selective agonist peptide (Rubixyl) contained in the spinach towards opioid receptor delta. In fact, agonist properties of both spinach peptides (Rubiscolin-5 and Rubixyl) towards opioid receptor delta were demonstrated by Zang et al., but their effects on the other opioid receptors were not studied [1]. We also studied the expression of opioid receptor delta in epidermis under normal and stress condition (inflammatory) and its role in epidermis homeostasis under stress condition in vitro and in vivo. Agonist properties studies were performed using functional agonist cellular model containing human opioid receptors. Opioid receptor delta expression and epidermis homeostasis were studied on human reconstructed epidermis under normal and stress conditions (inflammatory stress) using gene expression (RT-qPCR) and protein expression analysis (immunohistological analysis). Skin repair properties of opioid receptor delta agonist were based on the following parameters TEWL (trans epidermal water loss, hydration and wrinkle depth at periocular and perilabial area) on human volunteers having either intrinsic ageing (more than 40 years old and non-smoker group) and both intrinsic ageing and extrinsic ageing (more than 40 years old and smoker group). We have demonstrated that the Rubixyl peptide is a specific agonist of opioid receptor delta. We have demonstrated that opioid receptor delta expression is modulated under inflammatory condition. The agonist Rubixyl was able to block the depletion of opioid receptor delta seen under inflammatory condition in reconstructed human epidermis. Inflammatory conditions lead to the unbalanced gene and protein expressions of markers involved in epidermis integrity and barrier function properties. The treatment of human reconstructed epidermis with the agonist Rubixyl leads to the normalization of unbalanced gene and protein expressions. In vivo study has confirmed the efficiency of the agonist Rubixyl to repair damaged skin by decreasing TEWL, increasing hydration and decreasing wrinkle depth at the periocular and perilabial area. In this research, we have demonstrated in vitro (on inflamed reconstructed human epidermis, RHE) and in vivo (on human aged volunteers) that activation by natural agonist peptide of opioid receptor delta reduces the skin inflammation thus leading to improvement in epidermis differentiation and skin barrier properties.
abstractGer	The aims of this study were to confirm the properties of selective agonist peptide (Rubixyl) contained in the spinach towards opioid receptor delta. In fact, agonist properties of both spinach peptides (Rubiscolin-5 and Rubixyl) towards opioid receptor delta were demonstrated by Zang et al., but their effects on the other opioid receptors were not studied [1]. We also studied the expression of opioid receptor delta in epidermis under normal and stress condition (inflammatory) and its role in epidermis homeostasis under stress condition in vitro and in vivo. Agonist properties studies were performed using functional agonist cellular model containing human opioid receptors. Opioid receptor delta expression and epidermis homeostasis were studied on human reconstructed epidermis under normal and stress conditions (inflammatory stress) using gene expression (RT-qPCR) and protein expression analysis (immunohistological analysis). Skin repair properties of opioid receptor delta agonist were based on the following parameters TEWL (trans epidermal water loss, hydration and wrinkle depth at periocular and perilabial area) on human volunteers having either intrinsic ageing (more than 40 years old and non-smoker group) and both intrinsic ageing and extrinsic ageing (more than 40 years old and smoker group). We have demonstrated that the Rubixyl peptide is a specific agonist of opioid receptor delta. We have demonstrated that opioid receptor delta expression is modulated under inflammatory condition. The agonist Rubixyl was able to block the depletion of opioid receptor delta seen under inflammatory condition in reconstructed human epidermis. Inflammatory conditions lead to the unbalanced gene and protein expressions of markers involved in epidermis integrity and barrier function properties. The treatment of human reconstructed epidermis with the agonist Rubixyl leads to the normalization of unbalanced gene and protein expressions. In vivo study has confirmed the efficiency of the agonist Rubixyl to repair damaged skin by decreasing TEWL, increasing hydration and decreasing wrinkle depth at the periocular and perilabial area. In this research, we have demonstrated in vitro (on inflamed reconstructed human epidermis, RHE) and in vivo (on human aged volunteers) that activation by natural agonist peptide of opioid receptor delta reduces the skin inflammation thus leading to improvement in epidermis differentiation and skin barrier properties.
abstract_unstemmed	The aims of this study were to confirm the properties of selective agonist peptide (Rubixyl) contained in the spinach towards opioid receptor delta. In fact, agonist properties of both spinach peptides (Rubiscolin-5 and Rubixyl) towards opioid receptor delta were demonstrated by Zang et al., but their effects on the other opioid receptors were not studied [1]. We also studied the expression of opioid receptor delta in epidermis under normal and stress condition (inflammatory) and its role in epidermis homeostasis under stress condition in vitro and in vivo. Agonist properties studies were performed using functional agonist cellular model containing human opioid receptors. Opioid receptor delta expression and epidermis homeostasis were studied on human reconstructed epidermis under normal and stress conditions (inflammatory stress) using gene expression (RT-qPCR) and protein expression analysis (immunohistological analysis). Skin repair properties of opioid receptor delta agonist were based on the following parameters TEWL (trans epidermal water loss, hydration and wrinkle depth at periocular and perilabial area) on human volunteers having either intrinsic ageing (more than 40 years old and non-smoker group) and both intrinsic ageing and extrinsic ageing (more than 40 years old and smoker group). We have demonstrated that the Rubixyl peptide is a specific agonist of opioid receptor delta. We have demonstrated that opioid receptor delta expression is modulated under inflammatory condition. The agonist Rubixyl was able to block the depletion of opioid receptor delta seen under inflammatory condition in reconstructed human epidermis. Inflammatory conditions lead to the unbalanced gene and protein expressions of markers involved in epidermis integrity and barrier function properties. The treatment of human reconstructed epidermis with the agonist Rubixyl leads to the normalization of unbalanced gene and protein expressions. In vivo study has confirmed the efficiency of the agonist Rubixyl to repair damaged skin by decreasing TEWL, increasing hydration and decreasing wrinkle depth at the periocular and perilabial area. In this research, we have demonstrated in vitro (on inflamed reconstructed human epidermis, RHE) and in vivo (on human aged volunteers) that activation by natural agonist peptide of opioid receptor delta reduces the skin inflammation thus leading to improvement in epidermis differentiation and skin barrier properties.
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container_issue	4
title_short	Opioid receptor delta as a global modulator of skin differentiation and barrier function repair
url	http://dx.doi.org/10.1111/ics.12207 http://onlinelibrary.wiley.com/doi/10.1111/ics.12207/abstract http://www.ncbi.nlm.nih.gov/pubmed/25660727 http://search.proquest.com/docview/1693621181
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author2	Amstutz, B Schweikert, K Auriol, D Redziniak, G Lefèvre, F
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up_date	2024-07-04T03:07:49.793Z
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