Decoding the EGFR mutation-induced drug resistance in lung cancer treatment by local surface geometric properties
Epidermal growth factor receptor (EGFR) mutation-induced drug resistance leads to a limited efficacy of tyrosine kinase inhibitors during lung cancer treatments. In this study, we explore the correlations between the local surface geometric properties of EGFR mutants and the progression-free surviva...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Lichun Ma [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Rechteinformationen: |
Nutzungsrecht: Copyright © 2014 Elsevier Ltd. All rights reserved. |
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| Schlagwörter: |
Nuclear magnetic resonance--NMR |
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| Übergeordnetes Werk: |
Enthalten in: Computers in biology and medicine - New York, NY [u.a.] : Pergamon Press, 1970, 63(2015), Seite 293-300 |
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| Übergeordnetes Werk: |
volume:63 ; year:2015 ; pages:293-300 |
| Links: |
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| DOI / URN: |
10.1016/j.compbiomed.2014.06.016 |
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| 520 | |a Epidermal growth factor receptor (EGFR) mutation-induced drug resistance leads to a limited efficacy of tyrosine kinase inhibitors during lung cancer treatments. In this study, we explore the correlations between the local surface geometric properties of EGFR mutants and the progression-free survival (PFS). The geometric properties include local surface changes (four types) of the EGFR mutants compared with the wild-type EGFR, and the convex degrees of these local surfaces. Our analysis results show that the Spearman's rank correlation coefficients between the PFS and three types of local surface properties are all greater than 0.6 with smallP-values, implying a high significance. Moreover, the number of atoms with solid angles in the ranges of [0.71, 1], [0.61, 1] or [0.5, 1], indicating the convex degree of a local EGFR surface, also shows a strong correlation with the PFS. Overall, these characteristics can be efficiently applied to the prediction of drug resistance in lung cancer treatments, and easily extended to other cancer treatments. | ||
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| 650 | 4 | |a Nuclear magnetic resonance--NMR | |
| 650 | 4 | |a Drug resistance | |
| 650 | 4 | |a Methods | |
| 650 | 4 | |a Studies | |
| 650 | 4 | |a Solid angle | |
| 650 | 4 | |a Kinases | |
| 650 | 4 | |a Cancer therapies | |
| 650 | 4 | |a Crystal structure | |
| 650 | 4 | |a Alpha shape | |
| 650 | 4 | |a Proteins | |
| 650 | 4 | |a EGFR mutation | |
| 650 | 4 | |a Protein surface geometric properties | |
| 650 | 4 | |a Mutation | |
| 650 | 4 | |a Lung cancer | |
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| 700 | 0 | |a Yiqing Huang |4 oth | |
| 700 | 0 | |a Maria P Wong |4 oth | |
| 700 | 0 | |a Victor HF Lee |4 oth | |
| 700 | 0 | |a Hong Yan |4 oth | |
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10.1016/j.compbiomed.2014.06.016 doi PQ20160617 (DE-627)OLC1962382753 (DE-599)GBVOLC1962382753 (PRQ)c2764-6fefb7d101e7fa05627c7367ffea59df6839894693c3d950e4eacd81e44825380 (KEY)0003445220150000063000000293decodingtheegfrmutationinduceddrugresistanceinlung DE-627 ger DE-627 rakwb eng 610 570 DNB 44.00 bkl 42.00 bkl Lichun Ma verfasserin aut Decoding the EGFR mutation-induced drug resistance in lung cancer treatment by local surface geometric properties 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Epidermal growth factor receptor (EGFR) mutation-induced drug resistance leads to a limited efficacy of tyrosine kinase inhibitors during lung cancer treatments. In this study, we explore the correlations between the local surface geometric properties of EGFR mutants and the progression-free survival (PFS). The geometric properties include local surface changes (four types) of the EGFR mutants compared with the wild-type EGFR, and the convex degrees of these local surfaces. Our analysis results show that the Spearman's rank correlation coefficients between the PFS and three types of local surface properties are all greater than 0.6 with smallP-values, implying a high significance. Moreover, the number of atoms with solid angles in the ranges of [0.71, 1], [0.61, 1] or [0.5, 1], indicating the convex degree of a local EGFR surface, also shows a strong correlation with the PFS. Overall, these characteristics can be efficiently applied to the prediction of drug resistance in lung cancer treatments, and easily extended to other cancer treatments. Nutzungsrecht: Copyright © 2014 Elsevier Ltd. All rights reserved. Software Nuclear magnetic resonance--NMR Drug resistance Methods Studies Solid angle Kinases Cancer therapies Crystal structure Alpha shape Proteins EGFR mutation Protein surface geometric properties Mutation Lung cancer Debby D Wang oth Yiqing Huang oth Maria P Wong oth Victor HF Lee oth Hong Yan oth Enthalten in Computers in biology and medicine New York, NY [u.a.] : Pergamon Press, 1970 63(2015), Seite 293-300 (DE-627)129312789 (DE-600)127557-4 (DE-576)014525828 0010-4825 nnns volume:63 year:2015 pages:293-300 http://dx.doi.org/10.1016/j.compbiomed.2014.06.016 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25035232 http://search.proquest.com/docview/1692505464 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-MAT SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 44.00 AVZ 42.00 AVZ AR 63 2015 293-300 |
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10.1016/j.compbiomed.2014.06.016 doi PQ20160617 (DE-627)OLC1962382753 (DE-599)GBVOLC1962382753 (PRQ)c2764-6fefb7d101e7fa05627c7367ffea59df6839894693c3d950e4eacd81e44825380 (KEY)0003445220150000063000000293decodingtheegfrmutationinduceddrugresistanceinlung DE-627 ger DE-627 rakwb eng 610 570 DNB 44.00 bkl 42.00 bkl Lichun Ma verfasserin aut Decoding the EGFR mutation-induced drug resistance in lung cancer treatment by local surface geometric properties 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Epidermal growth factor receptor (EGFR) mutation-induced drug resistance leads to a limited efficacy of tyrosine kinase inhibitors during lung cancer treatments. In this study, we explore the correlations between the local surface geometric properties of EGFR mutants and the progression-free survival (PFS). The geometric properties include local surface changes (four types) of the EGFR mutants compared with the wild-type EGFR, and the convex degrees of these local surfaces. Our analysis results show that the Spearman's rank correlation coefficients between the PFS and three types of local surface properties are all greater than 0.6 with smallP-values, implying a high significance. Moreover, the number of atoms with solid angles in the ranges of [0.71, 1], [0.61, 1] or [0.5, 1], indicating the convex degree of a local EGFR surface, also shows a strong correlation with the PFS. Overall, these characteristics can be efficiently applied to the prediction of drug resistance in lung cancer treatments, and easily extended to other cancer treatments. Nutzungsrecht: Copyright © 2014 Elsevier Ltd. All rights reserved. Software Nuclear magnetic resonance--NMR Drug resistance Methods Studies Solid angle Kinases Cancer therapies Crystal structure Alpha shape Proteins EGFR mutation Protein surface geometric properties Mutation Lung cancer Debby D Wang oth Yiqing Huang oth Maria P Wong oth Victor HF Lee oth Hong Yan oth Enthalten in Computers in biology and medicine New York, NY [u.a.] : Pergamon Press, 1970 63(2015), Seite 293-300 (DE-627)129312789 (DE-600)127557-4 (DE-576)014525828 0010-4825 nnns volume:63 year:2015 pages:293-300 http://dx.doi.org/10.1016/j.compbiomed.2014.06.016 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25035232 http://search.proquest.com/docview/1692505464 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-MAT SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 44.00 AVZ 42.00 AVZ AR 63 2015 293-300 |
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10.1016/j.compbiomed.2014.06.016 doi PQ20160617 (DE-627)OLC1962382753 (DE-599)GBVOLC1962382753 (PRQ)c2764-6fefb7d101e7fa05627c7367ffea59df6839894693c3d950e4eacd81e44825380 (KEY)0003445220150000063000000293decodingtheegfrmutationinduceddrugresistanceinlung DE-627 ger DE-627 rakwb eng 610 570 DNB 44.00 bkl 42.00 bkl Lichun Ma verfasserin aut Decoding the EGFR mutation-induced drug resistance in lung cancer treatment by local surface geometric properties 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Epidermal growth factor receptor (EGFR) mutation-induced drug resistance leads to a limited efficacy of tyrosine kinase inhibitors during lung cancer treatments. In this study, we explore the correlations between the local surface geometric properties of EGFR mutants and the progression-free survival (PFS). The geometric properties include local surface changes (four types) of the EGFR mutants compared with the wild-type EGFR, and the convex degrees of these local surfaces. Our analysis results show that the Spearman's rank correlation coefficients between the PFS and three types of local surface properties are all greater than 0.6 with smallP-values, implying a high significance. Moreover, the number of atoms with solid angles in the ranges of [0.71, 1], [0.61, 1] or [0.5, 1], indicating the convex degree of a local EGFR surface, also shows a strong correlation with the PFS. Overall, these characteristics can be efficiently applied to the prediction of drug resistance in lung cancer treatments, and easily extended to other cancer treatments. Nutzungsrecht: Copyright © 2014 Elsevier Ltd. All rights reserved. Software Nuclear magnetic resonance--NMR Drug resistance Methods Studies Solid angle Kinases Cancer therapies Crystal structure Alpha shape Proteins EGFR mutation Protein surface geometric properties Mutation Lung cancer Debby D Wang oth Yiqing Huang oth Maria P Wong oth Victor HF Lee oth Hong Yan oth Enthalten in Computers in biology and medicine New York, NY [u.a.] : Pergamon Press, 1970 63(2015), Seite 293-300 (DE-627)129312789 (DE-600)127557-4 (DE-576)014525828 0010-4825 nnns volume:63 year:2015 pages:293-300 http://dx.doi.org/10.1016/j.compbiomed.2014.06.016 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25035232 http://search.proquest.com/docview/1692505464 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-MAT SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 44.00 AVZ 42.00 AVZ AR 63 2015 293-300 |
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10.1016/j.compbiomed.2014.06.016 doi PQ20160617 (DE-627)OLC1962382753 (DE-599)GBVOLC1962382753 (PRQ)c2764-6fefb7d101e7fa05627c7367ffea59df6839894693c3d950e4eacd81e44825380 (KEY)0003445220150000063000000293decodingtheegfrmutationinduceddrugresistanceinlung DE-627 ger DE-627 rakwb eng 610 570 DNB 44.00 bkl 42.00 bkl Lichun Ma verfasserin aut Decoding the EGFR mutation-induced drug resistance in lung cancer treatment by local surface geometric properties 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Epidermal growth factor receptor (EGFR) mutation-induced drug resistance leads to a limited efficacy of tyrosine kinase inhibitors during lung cancer treatments. In this study, we explore the correlations between the local surface geometric properties of EGFR mutants and the progression-free survival (PFS). The geometric properties include local surface changes (four types) of the EGFR mutants compared with the wild-type EGFR, and the convex degrees of these local surfaces. Our analysis results show that the Spearman's rank correlation coefficients between the PFS and three types of local surface properties are all greater than 0.6 with smallP-values, implying a high significance. Moreover, the number of atoms with solid angles in the ranges of [0.71, 1], [0.61, 1] or [0.5, 1], indicating the convex degree of a local EGFR surface, also shows a strong correlation with the PFS. Overall, these characteristics can be efficiently applied to the prediction of drug resistance in lung cancer treatments, and easily extended to other cancer treatments. Nutzungsrecht: Copyright © 2014 Elsevier Ltd. All rights reserved. Software Nuclear magnetic resonance--NMR Drug resistance Methods Studies Solid angle Kinases Cancer therapies Crystal structure Alpha shape Proteins EGFR mutation Protein surface geometric properties Mutation Lung cancer Debby D Wang oth Yiqing Huang oth Maria P Wong oth Victor HF Lee oth Hong Yan oth Enthalten in Computers in biology and medicine New York, NY [u.a.] : Pergamon Press, 1970 63(2015), Seite 293-300 (DE-627)129312789 (DE-600)127557-4 (DE-576)014525828 0010-4825 nnns volume:63 year:2015 pages:293-300 http://dx.doi.org/10.1016/j.compbiomed.2014.06.016 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25035232 http://search.proquest.com/docview/1692505464 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-MAT SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 44.00 AVZ 42.00 AVZ AR 63 2015 293-300 |
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decoding the egfr mutation-induced drug resistance in lung cancer treatment by local surface geometric properties |
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Decoding the EGFR mutation-induced drug resistance in lung cancer treatment by local surface geometric properties |
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Epidermal growth factor receptor (EGFR) mutation-induced drug resistance leads to a limited efficacy of tyrosine kinase inhibitors during lung cancer treatments. In this study, we explore the correlations between the local surface geometric properties of EGFR mutants and the progression-free survival (PFS). The geometric properties include local surface changes (four types) of the EGFR mutants compared with the wild-type EGFR, and the convex degrees of these local surfaces. Our analysis results show that the Spearman's rank correlation coefficients between the PFS and three types of local surface properties are all greater than 0.6 with smallP-values, implying a high significance. Moreover, the number of atoms with solid angles in the ranges of [0.71, 1], [0.61, 1] or [0.5, 1], indicating the convex degree of a local EGFR surface, also shows a strong correlation with the PFS. Overall, these characteristics can be efficiently applied to the prediction of drug resistance in lung cancer treatments, and easily extended to other cancer treatments. |
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Epidermal growth factor receptor (EGFR) mutation-induced drug resistance leads to a limited efficacy of tyrosine kinase inhibitors during lung cancer treatments. In this study, we explore the correlations between the local surface geometric properties of EGFR mutants and the progression-free survival (PFS). The geometric properties include local surface changes (four types) of the EGFR mutants compared with the wild-type EGFR, and the convex degrees of these local surfaces. Our analysis results show that the Spearman's rank correlation coefficients between the PFS and three types of local surface properties are all greater than 0.6 with smallP-values, implying a high significance. Moreover, the number of atoms with solid angles in the ranges of [0.71, 1], [0.61, 1] or [0.5, 1], indicating the convex degree of a local EGFR surface, also shows a strong correlation with the PFS. Overall, these characteristics can be efficiently applied to the prediction of drug resistance in lung cancer treatments, and easily extended to other cancer treatments. |
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Epidermal growth factor receptor (EGFR) mutation-induced drug resistance leads to a limited efficacy of tyrosine kinase inhibitors during lung cancer treatments. In this study, we explore the correlations between the local surface geometric properties of EGFR mutants and the progression-free survival (PFS). The geometric properties include local surface changes (four types) of the EGFR mutants compared with the wild-type EGFR, and the convex degrees of these local surfaces. Our analysis results show that the Spearman's rank correlation coefficients between the PFS and three types of local surface properties are all greater than 0.6 with smallP-values, implying a high significance. Moreover, the number of atoms with solid angles in the ranges of [0.71, 1], [0.61, 1] or [0.5, 1], indicating the convex degree of a local EGFR surface, also shows a strong correlation with the PFS. Overall, these characteristics can be efficiently applied to the prediction of drug resistance in lung cancer treatments, and easily extended to other cancer treatments. |
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Decoding the EGFR mutation-induced drug resistance in lung cancer treatment by local surface geometric properties |
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