Decoding the EGFR mutation-induced drug resistance in lung cancer treatment by local surface geometric properties

Epidermal growth factor receptor (EGFR) mutation-induced drug resistance leads to a limited efficacy of tyrosine kinase inhibitors during lung cancer treatments. In this study, we explore the correlations between the local surface geometric properties of EGFR mutants and the progression-free surviva...
Ausführliche Beschreibung

Gespeichert in:
Autor*in:

Lichun Ma [verfasserIn]

Debby D Wang

Yiqing Huang

Maria P Wong

Victor HF Lee

Hong Yan

Format:

Artikel

Sprache:

Englisch

Erschienen:

2015

Rechteinformationen:

Nutzungsrecht: Copyright © 2014 Elsevier Ltd. All rights reserved.

Schlagwörter:

Software

Nuclear magnetic resonance--NMR

Drug resistance

Methods

Studies

Solid angle

Kinases

Cancer therapies

Crystal structure

Alpha shape

Proteins

EGFR mutation

Protein surface geometric properties

Mutation

Lung cancer

Übergeordnetes Werk:

Enthalten in: Computers in biology and medicine - New York, NY [u.a.] : Pergamon Press, 1970, 63(2015), Seite 293-300

Übergeordnetes Werk:

volume:63 ; year:2015 ; pages:293-300

Links:

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DOI / URN:

10.1016/j.compbiomed.2014.06.016

Katalog-ID:

OLC1962382753

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