Exposure to traffic-related air pollution and the risk of developing breast cancer among women in eight Canadian provinces: a case-control study
A few recent studies have reported positive associations between long-term exposure to traffic-related air pollution and the incidence of breast cancer. We capitalized on an existing Canadian multi-site population-based case-control study to further investigate this association. We used the National...
Ausführliche Beschreibung
Autor*in: |
Hystad, Perry [verfasserIn] |
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Format: |
Artikel |
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Sprache: |
Englisch |
Erschienen: |
2015 |
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Rechteinformationen: |
Nutzungsrecht: Copyright © 2014 Elsevier Ltd. All rights reserved. |
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Schlagwörter: |
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Übergeordnetes Werk: |
Enthalten in: Environment international - New York, NY [u.a.] : Pergamon Press, 1978, 74(2015), Seite 240-248 |
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Übergeordnetes Werk: |
volume:74 ; year:2015 ; pages:240-248 |
Links: |
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DOI / URN: |
10.1016/j.envint.2014.09.004 |
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Katalog-ID: |
OLC1962415279 |
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520 | |a A few recent studies have reported positive associations between long-term exposure to traffic-related air pollution and the incidence of breast cancer. We capitalized on an existing Canadian multi-site population-based case-control study to further investigate this association. We used the National Enhanced Cancer Surveillance System, a population-based case-control study conducted in eight of 10 Canadian provinces from 1994 to 1997. A total of 1569 breast cancer cases and 1872 population controls who reported at least 90% complete self-reported addresses over the 1975-1994 exposure period were examined. Mean exposure levels to nitrogen dioxide (NO2) (an indicator of traffic-related air pollution) were estimated for this period using three different measures: (1) satellite-derived observations; (2) satellite-derived observations scaled with historical fixed-site measurements of NO2; and (3) a national land-use regression (LUR) model. Proximity to major roads was also examined. Using unconditional logistic regression, stratified by menopausal status, we estimated odds ratios (ORs) adjusted for many individual-level and contextual breast cancer risk factors. We observed positive associations between incident breast cancer and all three measures of NO2 exposure from 1975 to 1994. In fully adjusted models for premenopausal breast cancer, a 10ppb increase in NO2 exposure estimated from the satellite-derived observations, the scaled satellite-derived observations, and the national LUR model produced ORs of 1.26 (95% confidence intervals (CIs): 0.92-1.74), 1.32 (95% CI: 1.05-1.67) and 1.28 (95% CI: 0.92-1.79). For postmenopausal breast cancer, we found corresponding ORs of 1.10 (95% CI: 0.88-1.36), 1.10 (95% CI: 0.94-1.28) and 1.07 (95% CI: 0.86-1.32). Substantial heterogeneity in the ORs was observed across the eight Canadian provinces and reduced ORs were observed when models were restricted to women who had received routine mammography examinations. No associations were found for road proximity measures. This study provides some support for the hypothesis that traffic-related air pollution may be associated with the development of breast cancer, especially in premenopausal women. With the few studies available, further research is clearly needed. | ||
540 | |a Nutzungsrecht: Copyright © 2014 Elsevier Ltd. All rights reserved. | ||
650 | 4 | |a Nitrogen Dioxide - analysis | |
650 | 4 | |a Nitrogen Dioxide - toxicity | |
650 | 4 | |a Vehicle Emissions - toxicity | |
650 | 4 | |a Breast Neoplasms - epidemiology | |
650 | 4 | |a Air Pollutants - analysis | |
650 | 4 | |a Air Pollutants - toxicity | |
700 | 1 | |a Villeneuve, Paul J |4 oth | |
700 | 1 | |a Goldberg, Mark S |4 oth | |
700 | 1 | |a Crouse, Dan L |4 oth | |
700 | 1 | |a Johnson, Kenneth |4 oth | |
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10.1016/j.envint.2014.09.004 doi PQ20160617 (DE-627)OLC1962415279 (DE-599)GBVOLC1962415279 (PRQ)c1868-24ac6d0b74f958ef65e966ec74b09cab9d1c78f40ee5e6cf944a0fdb11f897240 (KEY)0003785020150000074000000240exposuretotrafficrelatedairpollutionandtheriskofde DE-627 ger DE-627 rakwb eng 610 600 690 DNB Hystad, Perry verfasserin aut Exposure to traffic-related air pollution and the risk of developing breast cancer among women in eight Canadian provinces: a case-control study 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier A few recent studies have reported positive associations between long-term exposure to traffic-related air pollution and the incidence of breast cancer. We capitalized on an existing Canadian multi-site population-based case-control study to further investigate this association. We used the National Enhanced Cancer Surveillance System, a population-based case-control study conducted in eight of 10 Canadian provinces from 1994 to 1997. A total of 1569 breast cancer cases and 1872 population controls who reported at least 90% complete self-reported addresses over the 1975-1994 exposure period were examined. Mean exposure levels to nitrogen dioxide (NO2) (an indicator of traffic-related air pollution) were estimated for this period using three different measures: (1) satellite-derived observations; (2) satellite-derived observations scaled with historical fixed-site measurements of NO2; and (3) a national land-use regression (LUR) model. Proximity to major roads was also examined. Using unconditional logistic regression, stratified by menopausal status, we estimated odds ratios (ORs) adjusted for many individual-level and contextual breast cancer risk factors. We observed positive associations between incident breast cancer and all three measures of NO2 exposure from 1975 to 1994. In fully adjusted models for premenopausal breast cancer, a 10ppb increase in NO2 exposure estimated from the satellite-derived observations, the scaled satellite-derived observations, and the national LUR model produced ORs of 1.26 (95% confidence intervals (CIs): 0.92-1.74), 1.32 (95% CI: 1.05-1.67) and 1.28 (95% CI: 0.92-1.79). For postmenopausal breast cancer, we found corresponding ORs of 1.10 (95% CI: 0.88-1.36), 1.10 (95% CI: 0.94-1.28) and 1.07 (95% CI: 0.86-1.32). Substantial heterogeneity in the ORs was observed across the eight Canadian provinces and reduced ORs were observed when models were restricted to women who had received routine mammography examinations. No associations were found for road proximity measures. This study provides some support for the hypothesis that traffic-related air pollution may be associated with the development of breast cancer, especially in premenopausal women. With the few studies available, further research is clearly needed. Nutzungsrecht: Copyright © 2014 Elsevier Ltd. All rights reserved. Nitrogen Dioxide - analysis Nitrogen Dioxide - toxicity Vehicle Emissions - toxicity Breast Neoplasms - epidemiology Air Pollutants - analysis Air Pollutants - toxicity Villeneuve, Paul J oth Goldberg, Mark S oth Crouse, Dan L oth Johnson, Kenneth oth Enthalten in Environment international New York, NY [u.a.] : Pergamon Press, 1978 74(2015), Seite 240-248 (DE-627)130256250 (DE-600)554791-X (DE-576)019338546 0160-4120 nnns volume:74 year:2015 pages:240-248 http://dx.doi.org/10.1016/j.envint.2014.09.004 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25454241 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-FOR SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_4012 AR 74 2015 240-248 |
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10.1016/j.envint.2014.09.004 doi PQ20160617 (DE-627)OLC1962415279 (DE-599)GBVOLC1962415279 (PRQ)c1868-24ac6d0b74f958ef65e966ec74b09cab9d1c78f40ee5e6cf944a0fdb11f897240 (KEY)0003785020150000074000000240exposuretotrafficrelatedairpollutionandtheriskofde DE-627 ger DE-627 rakwb eng 610 600 690 DNB Hystad, Perry verfasserin aut Exposure to traffic-related air pollution and the risk of developing breast cancer among women in eight Canadian provinces: a case-control study 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier A few recent studies have reported positive associations between long-term exposure to traffic-related air pollution and the incidence of breast cancer. We capitalized on an existing Canadian multi-site population-based case-control study to further investigate this association. We used the National Enhanced Cancer Surveillance System, a population-based case-control study conducted in eight of 10 Canadian provinces from 1994 to 1997. A total of 1569 breast cancer cases and 1872 population controls who reported at least 90% complete self-reported addresses over the 1975-1994 exposure period were examined. Mean exposure levels to nitrogen dioxide (NO2) (an indicator of traffic-related air pollution) were estimated for this period using three different measures: (1) satellite-derived observations; (2) satellite-derived observations scaled with historical fixed-site measurements of NO2; and (3) a national land-use regression (LUR) model. Proximity to major roads was also examined. Using unconditional logistic regression, stratified by menopausal status, we estimated odds ratios (ORs) adjusted for many individual-level and contextual breast cancer risk factors. We observed positive associations between incident breast cancer and all three measures of NO2 exposure from 1975 to 1994. In fully adjusted models for premenopausal breast cancer, a 10ppb increase in NO2 exposure estimated from the satellite-derived observations, the scaled satellite-derived observations, and the national LUR model produced ORs of 1.26 (95% confidence intervals (CIs): 0.92-1.74), 1.32 (95% CI: 1.05-1.67) and 1.28 (95% CI: 0.92-1.79). For postmenopausal breast cancer, we found corresponding ORs of 1.10 (95% CI: 0.88-1.36), 1.10 (95% CI: 0.94-1.28) and 1.07 (95% CI: 0.86-1.32). Substantial heterogeneity in the ORs was observed across the eight Canadian provinces and reduced ORs were observed when models were restricted to women who had received routine mammography examinations. No associations were found for road proximity measures. This study provides some support for the hypothesis that traffic-related air pollution may be associated with the development of breast cancer, especially in premenopausal women. With the few studies available, further research is clearly needed. Nutzungsrecht: Copyright © 2014 Elsevier Ltd. All rights reserved. Nitrogen Dioxide - analysis Nitrogen Dioxide - toxicity Vehicle Emissions - toxicity Breast Neoplasms - epidemiology Air Pollutants - analysis Air Pollutants - toxicity Villeneuve, Paul J oth Goldberg, Mark S oth Crouse, Dan L oth Johnson, Kenneth oth Enthalten in Environment international New York, NY [u.a.] : Pergamon Press, 1978 74(2015), Seite 240-248 (DE-627)130256250 (DE-600)554791-X (DE-576)019338546 0160-4120 nnns volume:74 year:2015 pages:240-248 http://dx.doi.org/10.1016/j.envint.2014.09.004 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25454241 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-FOR SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_4012 AR 74 2015 240-248 |
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10.1016/j.envint.2014.09.004 doi PQ20160617 (DE-627)OLC1962415279 (DE-599)GBVOLC1962415279 (PRQ)c1868-24ac6d0b74f958ef65e966ec74b09cab9d1c78f40ee5e6cf944a0fdb11f897240 (KEY)0003785020150000074000000240exposuretotrafficrelatedairpollutionandtheriskofde DE-627 ger DE-627 rakwb eng 610 600 690 DNB Hystad, Perry verfasserin aut Exposure to traffic-related air pollution and the risk of developing breast cancer among women in eight Canadian provinces: a case-control study 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier A few recent studies have reported positive associations between long-term exposure to traffic-related air pollution and the incidence of breast cancer. We capitalized on an existing Canadian multi-site population-based case-control study to further investigate this association. We used the National Enhanced Cancer Surveillance System, a population-based case-control study conducted in eight of 10 Canadian provinces from 1994 to 1997. A total of 1569 breast cancer cases and 1872 population controls who reported at least 90% complete self-reported addresses over the 1975-1994 exposure period were examined. Mean exposure levels to nitrogen dioxide (NO2) (an indicator of traffic-related air pollution) were estimated for this period using three different measures: (1) satellite-derived observations; (2) satellite-derived observations scaled with historical fixed-site measurements of NO2; and (3) a national land-use regression (LUR) model. Proximity to major roads was also examined. Using unconditional logistic regression, stratified by menopausal status, we estimated odds ratios (ORs) adjusted for many individual-level and contextual breast cancer risk factors. We observed positive associations between incident breast cancer and all three measures of NO2 exposure from 1975 to 1994. In fully adjusted models for premenopausal breast cancer, a 10ppb increase in NO2 exposure estimated from the satellite-derived observations, the scaled satellite-derived observations, and the national LUR model produced ORs of 1.26 (95% confidence intervals (CIs): 0.92-1.74), 1.32 (95% CI: 1.05-1.67) and 1.28 (95% CI: 0.92-1.79). For postmenopausal breast cancer, we found corresponding ORs of 1.10 (95% CI: 0.88-1.36), 1.10 (95% CI: 0.94-1.28) and 1.07 (95% CI: 0.86-1.32). Substantial heterogeneity in the ORs was observed across the eight Canadian provinces and reduced ORs were observed when models were restricted to women who had received routine mammography examinations. No associations were found for road proximity measures. This study provides some support for the hypothesis that traffic-related air pollution may be associated with the development of breast cancer, especially in premenopausal women. With the few studies available, further research is clearly needed. Nutzungsrecht: Copyright © 2014 Elsevier Ltd. All rights reserved. Nitrogen Dioxide - analysis Nitrogen Dioxide - toxicity Vehicle Emissions - toxicity Breast Neoplasms - epidemiology Air Pollutants - analysis Air Pollutants - toxicity Villeneuve, Paul J oth Goldberg, Mark S oth Crouse, Dan L oth Johnson, Kenneth oth Enthalten in Environment international New York, NY [u.a.] : Pergamon Press, 1978 74(2015), Seite 240-248 (DE-627)130256250 (DE-600)554791-X (DE-576)019338546 0160-4120 nnns volume:74 year:2015 pages:240-248 http://dx.doi.org/10.1016/j.envint.2014.09.004 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25454241 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-FOR SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_4012 AR 74 2015 240-248 |
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10.1016/j.envint.2014.09.004 doi PQ20160617 (DE-627)OLC1962415279 (DE-599)GBVOLC1962415279 (PRQ)c1868-24ac6d0b74f958ef65e966ec74b09cab9d1c78f40ee5e6cf944a0fdb11f897240 (KEY)0003785020150000074000000240exposuretotrafficrelatedairpollutionandtheriskofde DE-627 ger DE-627 rakwb eng 610 600 690 DNB Hystad, Perry verfasserin aut Exposure to traffic-related air pollution and the risk of developing breast cancer among women in eight Canadian provinces: a case-control study 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier A few recent studies have reported positive associations between long-term exposure to traffic-related air pollution and the incidence of breast cancer. We capitalized on an existing Canadian multi-site population-based case-control study to further investigate this association. We used the National Enhanced Cancer Surveillance System, a population-based case-control study conducted in eight of 10 Canadian provinces from 1994 to 1997. A total of 1569 breast cancer cases and 1872 population controls who reported at least 90% complete self-reported addresses over the 1975-1994 exposure period were examined. Mean exposure levels to nitrogen dioxide (NO2) (an indicator of traffic-related air pollution) were estimated for this period using three different measures: (1) satellite-derived observations; (2) satellite-derived observations scaled with historical fixed-site measurements of NO2; and (3) a national land-use regression (LUR) model. Proximity to major roads was also examined. Using unconditional logistic regression, stratified by menopausal status, we estimated odds ratios (ORs) adjusted for many individual-level and contextual breast cancer risk factors. We observed positive associations between incident breast cancer and all three measures of NO2 exposure from 1975 to 1994. In fully adjusted models for premenopausal breast cancer, a 10ppb increase in NO2 exposure estimated from the satellite-derived observations, the scaled satellite-derived observations, and the national LUR model produced ORs of 1.26 (95% confidence intervals (CIs): 0.92-1.74), 1.32 (95% CI: 1.05-1.67) and 1.28 (95% CI: 0.92-1.79). For postmenopausal breast cancer, we found corresponding ORs of 1.10 (95% CI: 0.88-1.36), 1.10 (95% CI: 0.94-1.28) and 1.07 (95% CI: 0.86-1.32). Substantial heterogeneity in the ORs was observed across the eight Canadian provinces and reduced ORs were observed when models were restricted to women who had received routine mammography examinations. No associations were found for road proximity measures. This study provides some support for the hypothesis that traffic-related air pollution may be associated with the development of breast cancer, especially in premenopausal women. With the few studies available, further research is clearly needed. Nutzungsrecht: Copyright © 2014 Elsevier Ltd. All rights reserved. Nitrogen Dioxide - analysis Nitrogen Dioxide - toxicity Vehicle Emissions - toxicity Breast Neoplasms - epidemiology Air Pollutants - analysis Air Pollutants - toxicity Villeneuve, Paul J oth Goldberg, Mark S oth Crouse, Dan L oth Johnson, Kenneth oth Enthalten in Environment international New York, NY [u.a.] : Pergamon Press, 1978 74(2015), Seite 240-248 (DE-627)130256250 (DE-600)554791-X (DE-576)019338546 0160-4120 nnns volume:74 year:2015 pages:240-248 http://dx.doi.org/10.1016/j.envint.2014.09.004 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25454241 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-FOR SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_4012 AR 74 2015 240-248 |
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10.1016/j.envint.2014.09.004 doi PQ20160617 (DE-627)OLC1962415279 (DE-599)GBVOLC1962415279 (PRQ)c1868-24ac6d0b74f958ef65e966ec74b09cab9d1c78f40ee5e6cf944a0fdb11f897240 (KEY)0003785020150000074000000240exposuretotrafficrelatedairpollutionandtheriskofde DE-627 ger DE-627 rakwb eng 610 600 690 DNB Hystad, Perry verfasserin aut Exposure to traffic-related air pollution and the risk of developing breast cancer among women in eight Canadian provinces: a case-control study 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier A few recent studies have reported positive associations between long-term exposure to traffic-related air pollution and the incidence of breast cancer. We capitalized on an existing Canadian multi-site population-based case-control study to further investigate this association. We used the National Enhanced Cancer Surveillance System, a population-based case-control study conducted in eight of 10 Canadian provinces from 1994 to 1997. A total of 1569 breast cancer cases and 1872 population controls who reported at least 90% complete self-reported addresses over the 1975-1994 exposure period were examined. Mean exposure levels to nitrogen dioxide (NO2) (an indicator of traffic-related air pollution) were estimated for this period using three different measures: (1) satellite-derived observations; (2) satellite-derived observations scaled with historical fixed-site measurements of NO2; and (3) a national land-use regression (LUR) model. Proximity to major roads was also examined. Using unconditional logistic regression, stratified by menopausal status, we estimated odds ratios (ORs) adjusted for many individual-level and contextual breast cancer risk factors. We observed positive associations between incident breast cancer and all three measures of NO2 exposure from 1975 to 1994. In fully adjusted models for premenopausal breast cancer, a 10ppb increase in NO2 exposure estimated from the satellite-derived observations, the scaled satellite-derived observations, and the national LUR model produced ORs of 1.26 (95% confidence intervals (CIs): 0.92-1.74), 1.32 (95% CI: 1.05-1.67) and 1.28 (95% CI: 0.92-1.79). For postmenopausal breast cancer, we found corresponding ORs of 1.10 (95% CI: 0.88-1.36), 1.10 (95% CI: 0.94-1.28) and 1.07 (95% CI: 0.86-1.32). Substantial heterogeneity in the ORs was observed across the eight Canadian provinces and reduced ORs were observed when models were restricted to women who had received routine mammography examinations. No associations were found for road proximity measures. This study provides some support for the hypothesis that traffic-related air pollution may be associated with the development of breast cancer, especially in premenopausal women. With the few studies available, further research is clearly needed. Nutzungsrecht: Copyright © 2014 Elsevier Ltd. All rights reserved. Nitrogen Dioxide - analysis Nitrogen Dioxide - toxicity Vehicle Emissions - toxicity Breast Neoplasms - epidemiology Air Pollutants - analysis Air Pollutants - toxicity Villeneuve, Paul J oth Goldberg, Mark S oth Crouse, Dan L oth Johnson, Kenneth oth Enthalten in Environment international New York, NY [u.a.] : Pergamon Press, 1978 74(2015), Seite 240-248 (DE-627)130256250 (DE-600)554791-X (DE-576)019338546 0160-4120 nnns volume:74 year:2015 pages:240-248 http://dx.doi.org/10.1016/j.envint.2014.09.004 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25454241 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-FOR SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_4012 AR 74 2015 240-248 |
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exposure to traffic-related air pollution and the risk of developing breast cancer among women in eight canadian provinces: a case-control study |
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Exposure to traffic-related air pollution and the risk of developing breast cancer among women in eight Canadian provinces: a case-control study |
abstract |
A few recent studies have reported positive associations between long-term exposure to traffic-related air pollution and the incidence of breast cancer. We capitalized on an existing Canadian multi-site population-based case-control study to further investigate this association. We used the National Enhanced Cancer Surveillance System, a population-based case-control study conducted in eight of 10 Canadian provinces from 1994 to 1997. A total of 1569 breast cancer cases and 1872 population controls who reported at least 90% complete self-reported addresses over the 1975-1994 exposure period were examined. Mean exposure levels to nitrogen dioxide (NO2) (an indicator of traffic-related air pollution) were estimated for this period using three different measures: (1) satellite-derived observations; (2) satellite-derived observations scaled with historical fixed-site measurements of NO2; and (3) a national land-use regression (LUR) model. Proximity to major roads was also examined. Using unconditional logistic regression, stratified by menopausal status, we estimated odds ratios (ORs) adjusted for many individual-level and contextual breast cancer risk factors. We observed positive associations between incident breast cancer and all three measures of NO2 exposure from 1975 to 1994. In fully adjusted models for premenopausal breast cancer, a 10ppb increase in NO2 exposure estimated from the satellite-derived observations, the scaled satellite-derived observations, and the national LUR model produced ORs of 1.26 (95% confidence intervals (CIs): 0.92-1.74), 1.32 (95% CI: 1.05-1.67) and 1.28 (95% CI: 0.92-1.79). For postmenopausal breast cancer, we found corresponding ORs of 1.10 (95% CI: 0.88-1.36), 1.10 (95% CI: 0.94-1.28) and 1.07 (95% CI: 0.86-1.32). Substantial heterogeneity in the ORs was observed across the eight Canadian provinces and reduced ORs were observed when models were restricted to women who had received routine mammography examinations. No associations were found for road proximity measures. This study provides some support for the hypothesis that traffic-related air pollution may be associated with the development of breast cancer, especially in premenopausal women. With the few studies available, further research is clearly needed. |
abstractGer |
A few recent studies have reported positive associations between long-term exposure to traffic-related air pollution and the incidence of breast cancer. We capitalized on an existing Canadian multi-site population-based case-control study to further investigate this association. We used the National Enhanced Cancer Surveillance System, a population-based case-control study conducted in eight of 10 Canadian provinces from 1994 to 1997. A total of 1569 breast cancer cases and 1872 population controls who reported at least 90% complete self-reported addresses over the 1975-1994 exposure period were examined. Mean exposure levels to nitrogen dioxide (NO2) (an indicator of traffic-related air pollution) were estimated for this period using three different measures: (1) satellite-derived observations; (2) satellite-derived observations scaled with historical fixed-site measurements of NO2; and (3) a national land-use regression (LUR) model. Proximity to major roads was also examined. Using unconditional logistic regression, stratified by menopausal status, we estimated odds ratios (ORs) adjusted for many individual-level and contextual breast cancer risk factors. We observed positive associations between incident breast cancer and all three measures of NO2 exposure from 1975 to 1994. In fully adjusted models for premenopausal breast cancer, a 10ppb increase in NO2 exposure estimated from the satellite-derived observations, the scaled satellite-derived observations, and the national LUR model produced ORs of 1.26 (95% confidence intervals (CIs): 0.92-1.74), 1.32 (95% CI: 1.05-1.67) and 1.28 (95% CI: 0.92-1.79). For postmenopausal breast cancer, we found corresponding ORs of 1.10 (95% CI: 0.88-1.36), 1.10 (95% CI: 0.94-1.28) and 1.07 (95% CI: 0.86-1.32). Substantial heterogeneity in the ORs was observed across the eight Canadian provinces and reduced ORs were observed when models were restricted to women who had received routine mammography examinations. No associations were found for road proximity measures. This study provides some support for the hypothesis that traffic-related air pollution may be associated with the development of breast cancer, especially in premenopausal women. With the few studies available, further research is clearly needed. |
abstract_unstemmed |
A few recent studies have reported positive associations between long-term exposure to traffic-related air pollution and the incidence of breast cancer. We capitalized on an existing Canadian multi-site population-based case-control study to further investigate this association. We used the National Enhanced Cancer Surveillance System, a population-based case-control study conducted in eight of 10 Canadian provinces from 1994 to 1997. A total of 1569 breast cancer cases and 1872 population controls who reported at least 90% complete self-reported addresses over the 1975-1994 exposure period were examined. Mean exposure levels to nitrogen dioxide (NO2) (an indicator of traffic-related air pollution) were estimated for this period using three different measures: (1) satellite-derived observations; (2) satellite-derived observations scaled with historical fixed-site measurements of NO2; and (3) a national land-use regression (LUR) model. Proximity to major roads was also examined. Using unconditional logistic regression, stratified by menopausal status, we estimated odds ratios (ORs) adjusted for many individual-level and contextual breast cancer risk factors. We observed positive associations between incident breast cancer and all three measures of NO2 exposure from 1975 to 1994. In fully adjusted models for premenopausal breast cancer, a 10ppb increase in NO2 exposure estimated from the satellite-derived observations, the scaled satellite-derived observations, and the national LUR model produced ORs of 1.26 (95% confidence intervals (CIs): 0.92-1.74), 1.32 (95% CI: 1.05-1.67) and 1.28 (95% CI: 0.92-1.79). For postmenopausal breast cancer, we found corresponding ORs of 1.10 (95% CI: 0.88-1.36), 1.10 (95% CI: 0.94-1.28) and 1.07 (95% CI: 0.86-1.32). Substantial heterogeneity in the ORs was observed across the eight Canadian provinces and reduced ORs were observed when models were restricted to women who had received routine mammography examinations. No associations were found for road proximity measures. This study provides some support for the hypothesis that traffic-related air pollution may be associated with the development of breast cancer, especially in premenopausal women. With the few studies available, further research is clearly needed. |
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title_short |
Exposure to traffic-related air pollution and the risk of developing breast cancer among women in eight Canadian provinces: a case-control study |
url |
http://dx.doi.org/10.1016/j.envint.2014.09.004 http://www.ncbi.nlm.nih.gov/pubmed/25454241 |
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Using unconditional logistic regression, stratified by menopausal status, we estimated odds ratios (ORs) adjusted for many individual-level and contextual breast cancer risk factors. We observed positive associations between incident breast cancer and all three measures of NO2 exposure from 1975 to 1994. In fully adjusted models for premenopausal breast cancer, a 10ppb increase in NO2 exposure estimated from the satellite-derived observations, the scaled satellite-derived observations, and the national LUR model produced ORs of 1.26 (95% confidence intervals (CIs): 0.92-1.74), 1.32 (95% CI: 1.05-1.67) and 1.28 (95% CI: 0.92-1.79). For postmenopausal breast cancer, we found corresponding ORs of 1.10 (95% CI: 0.88-1.36), 1.10 (95% CI: 0.94-1.28) and 1.07 (95% CI: 0.86-1.32). Substantial heterogeneity in the ORs was observed across the eight Canadian provinces and reduced ORs were observed when models were restricted to women who had received routine mammography examinations. No associations were found for road proximity measures. This study provides some support for the hypothesis that traffic-related air pollution may be associated with the development of breast cancer, especially in premenopausal women. With the few studies available, further research is clearly needed.</subfield></datafield><datafield tag="540" ind1=" " ind2=" "><subfield code="a">Nutzungsrecht: Copyright © 2014 Elsevier Ltd. All rights reserved.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Nitrogen Dioxide - analysis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Nitrogen Dioxide - toxicity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Vehicle Emissions - toxicity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Breast Neoplasms - epidemiology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Air Pollutants - analysis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Air Pollutants - toxicity</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Villeneuve, Paul J</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Goldberg, Mark S</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Crouse, Dan L</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Johnson, Kenneth</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Environment international</subfield><subfield code="d">New York, NY [u.a.] : Pergamon Press, 1978</subfield><subfield code="g">74(2015), Seite 240-248</subfield><subfield code="w">(DE-627)130256250</subfield><subfield code="w">(DE-600)554791-X</subfield><subfield code="w">(DE-576)019338546</subfield><subfield code="x">0160-4120</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:74</subfield><subfield code="g">year:2015</subfield><subfield code="g">pages:240-248</subfield></datafield><datafield tag="856" ind1="4" ind2="1"><subfield code="u">http://dx.doi.org/10.1016/j.envint.2014.09.004</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">http://www.ncbi.nlm.nih.gov/pubmed/25454241</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_OLC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-UMW</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-ARC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-TEC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-FOR</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-IBL</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-DE-84</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">74</subfield><subfield code="j">2015</subfield><subfield code="h">240-248</subfield></datafield></record></collection>
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