Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

The role of cellular metabolism in regulating cell proliferation and differentiation remains poorly understood. For example, most mammalian cells cannot proliferate without exogenous glutamine supplementation even though glutamine is a non-essential amino acid. Here we show that mouse embryonic stem...
Ausführliche Beschreibung

Gespeichert in:
Autor*in:

Carey, Bryce W [verfasserIn]

Finley, Lydia W S

Cross, Justin R

Allis, C David

Thompson, Craig B

Format:

Artikel

Sprache:

Englisch

Erschienen:

2015

Schlagwörter:

Histones - metabolism

Embryonic Stem Cells - metabolism

Transcription, Genetic - drug effects

Intracellular Space - metabolism

Embryonic Stem Cells - drug effects

Embryonic Stem Cells - cytology

DNA Methylation - drug effects

Succinic Acid - metabolism

Epigenesis, Genetic - genetics

Pluripotent Stem Cells - metabolism

Pluripotent Stem Cells - drug effects

Ketoglutaric Acids - metabolism

Chromatin - drug effects

Ketoglutaric Acids - pharmacology

Glutamic Acid - metabolism

Cell Differentiation - drug effects

Pluripotent Stem Cells - cytology

Succinic Acid - pharmacology

Glucose - metabolism

Epigenesis, Genetic - drug effects

Übergeordnetes Werk:

Enthalten in: Nature - London : Macmillan Publishers Limited, part of Springer Nature, 1869, 518(2015), 7539, Seite 413-416

Übergeordnetes Werk:

volume:518 ; year:2015 ; number:7539 ; pages:413-416

Links:

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DOI / URN:

10.1038/nature13981

Katalog-ID:

OLC1962477436

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