Genetic studies of body mass index yield new insights for obesity biology
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in upto 339,224 individuals...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Locke, Adam E [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Rechteinformationen: |
Nutzungsrecht: © info:eu-repo/semantics/restrictedAccess |
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| Übergeordnetes Werk: |
Enthalten in: Nature - London : Macmillan Publishers Limited, part of Springer Nature, 1869, (2015) |
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| Übergeordnetes Werk: |
year:2015 |
| Links: |
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| DOI / URN: |
10.1038/nature14177 |
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OLC1962477916 |
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| 245 | 1 | 0 | |a Genetic studies of body mass index yield new insights for obesity biology |
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| 520 | |a Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in upto 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 x 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for similar to 2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous systemin obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis. | ||
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10.1038/nature14177 doi PQ20160617 (DE-627)OLC1962477916 (DE-599)GBVOLC1962477916 (PRQ)dalarna_diva_oai_DiVA_org_du_171690 (KEY)0072945020150000000000000000geneticstudiesofbodymassindexyieldnewinsightsforob DE-627 ger DE-627 rakwb eng 070 500 DNB 500 AVZ BIODIV fid Locke, Adam E verfasserin aut Genetic studies of body mass index yield new insights for obesity biology 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in upto 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 x 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for similar to 2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous systemin obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis. Nutzungsrecht: © info:eu-repo/semantics/restrictedAccess Kahali, Bratati oth Berndt, Sonja I oth Justice, Anne E oth Pers, Tune H oth Day, Felix R oth Powell, Corey oth Vedantam, Sailaja oth Buchkovich, Martin L oth Yang, Jian oth Croteau-Chonka, Damien C oth Esko, Tonu oth Fall, Tove oth Ferreira, Teresa oth Gustafsson, Stefan oth Kutalik, Zoltan oth Luan, Jian'an oth Maegi, Reedik oth Randall, Joshua C oth Winkler, Thomas W oth Wood, Andrew R oth Workalemahu, Tsegaselassie oth Faul, Jessica D oth Smith, Jennifer A oth Zhao, Jing Hua oth Zhao, Wei oth Chen, Jin oth Fehrmann, Rudolf oth Hedman, Asa K oth Karjalainen, Juha oth Schmidt, Ellen M oth Absher, Devin oth Amin, Najaf oth Anderson, Denise oth Beekman, Marian oth Bolton, Jennifer L oth Bragg-Gresham, L oth Buyske, Steven oth Demirkan, Ayse oth Deng, Guohong oth Ehret, Georg B oth Feenstra, Bjarke oth Feitosa, Mary F oth Fischer, Krista oth Goel, Anuj oth Gong, Jian oth Jackson, Anne U oth Kanoni, Stavroula oth Kleber, Marcus E oth Kristiansson, Kati oth Lim, Unhee oth Lotay, Vaneet oth Mangino, Massimo oth Leach, Irene Mateo oth Medina-Gomez, Carolina oth Medland, Sarah E oth Nalls, Michael A oth Palmer, Cameron D oth Pasko, Dorota oth Pechlivanis, Sonali oth Peters, Marjolein J oth Prokopenko, Inga oth Shungin, Dmitry oth Stancakova, Alena oth Strawbridge, Rona J oth Sung, Yun Ju oth Tanaka, Toshiko oth Teumer, Alexander oth Trompet, Stella oth van der Laan, Sander W oth van Settee, Jessica oth Van Vliet-Ostaptchouk, Jana V oth Wang, Zhaoming oth Yengo, Loic oth Zhang, Weihua oth Isaacs, Aaron oth Albrecht, Eva oth Ärnlöv, Johan oth Arscott, Gillian M oth Attwood, Antony P oth Bandinelli, Stefania oth Barrett, Amy oth Bas, Isabelita N oth Bellis, Claire oth Bennett, Amanda J oth Berne, Christian oth Blagieva, Roza oth Blueher, Matthias oth Bohringer, Stefan oth Bonnycastle, Lori L oth Boettcher, Yvonne oth Boyd, Heather A oth Bruinenberg, Marcel oth Caspersen, Ida H oth Chen, Yii-Der Ida oth Clarke, Robert oth Daw, E. Warwick oth de Craen, Anton J. M oth Delgado, Graciela oth Dimitriou, Maria oth ... oth Enthalten in Nature London : Macmillan Publishers Limited, part of Springer Nature, 1869 (2015) (DE-627)129292834 (DE-600)120714-3 (DE-576)014473941 0028-0836 nnns year:2015 http://dx.doi.org/10.1038/nature14177 Volltext http://urn.kb.se/resolve?urn=urn:nbn:se:du-17169 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_30 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_100 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_154 GBV_ILN_160 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_267 GBV_ILN_290 GBV_ILN_294 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2015 GBV_ILN_2016 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2095 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4700 AR 2015 |
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10.1038/nature14177 doi PQ20160617 (DE-627)OLC1962477916 (DE-599)GBVOLC1962477916 (PRQ)dalarna_diva_oai_DiVA_org_du_171690 (KEY)0072945020150000000000000000geneticstudiesofbodymassindexyieldnewinsightsforob DE-627 ger DE-627 rakwb eng 070 500 DNB 500 AVZ BIODIV fid Locke, Adam E verfasserin aut Genetic studies of body mass index yield new insights for obesity biology 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in upto 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 x 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for similar to 2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous systemin obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis. Nutzungsrecht: © info:eu-repo/semantics/restrictedAccess Kahali, Bratati oth Berndt, Sonja I oth Justice, Anne E oth Pers, Tune H oth Day, Felix R oth Powell, Corey oth Vedantam, Sailaja oth Buchkovich, Martin L oth Yang, Jian oth Croteau-Chonka, Damien C oth Esko, Tonu oth Fall, Tove oth Ferreira, Teresa oth Gustafsson, Stefan oth Kutalik, Zoltan oth Luan, Jian'an oth Maegi, Reedik oth Randall, Joshua C oth Winkler, Thomas W oth Wood, Andrew R oth Workalemahu, Tsegaselassie oth Faul, Jessica D oth Smith, Jennifer A oth Zhao, Jing Hua oth Zhao, Wei oth Chen, Jin oth Fehrmann, Rudolf oth Hedman, Asa K oth Karjalainen, Juha oth Schmidt, Ellen M oth Absher, Devin oth Amin, Najaf oth Anderson, Denise oth Beekman, Marian oth Bolton, Jennifer L oth Bragg-Gresham, L oth Buyske, Steven oth Demirkan, Ayse oth Deng, Guohong oth Ehret, Georg B oth Feenstra, Bjarke oth Feitosa, Mary F oth Fischer, Krista oth Goel, Anuj oth Gong, Jian oth Jackson, Anne U oth Kanoni, Stavroula oth Kleber, Marcus E oth Kristiansson, Kati oth Lim, Unhee oth Lotay, Vaneet oth Mangino, Massimo oth Leach, Irene Mateo oth Medina-Gomez, Carolina oth Medland, Sarah E oth Nalls, Michael A oth Palmer, Cameron D oth Pasko, Dorota oth Pechlivanis, Sonali oth Peters, Marjolein J oth Prokopenko, Inga oth Shungin, Dmitry oth Stancakova, Alena oth Strawbridge, Rona J oth Sung, Yun Ju oth Tanaka, Toshiko oth Teumer, Alexander oth Trompet, Stella oth van der Laan, Sander W oth van Settee, Jessica oth Van Vliet-Ostaptchouk, Jana V oth Wang, Zhaoming oth Yengo, Loic oth Zhang, Weihua oth Isaacs, Aaron oth Albrecht, Eva oth Ärnlöv, Johan oth Arscott, Gillian M oth Attwood, Antony P oth Bandinelli, Stefania oth Barrett, Amy oth Bas, Isabelita N oth Bellis, Claire oth Bennett, Amanda J oth Berne, Christian oth Blagieva, Roza oth Blueher, Matthias oth Bohringer, Stefan oth Bonnycastle, Lori L oth Boettcher, Yvonne oth Boyd, Heather A oth Bruinenberg, Marcel oth Caspersen, Ida H oth Chen, Yii-Der Ida oth Clarke, Robert oth Daw, E. Warwick oth de Craen, Anton J. M oth Delgado, Graciela oth Dimitriou, Maria oth ... oth Enthalten in Nature London : Macmillan Publishers Limited, part of Springer Nature, 1869 (2015) (DE-627)129292834 (DE-600)120714-3 (DE-576)014473941 0028-0836 nnns year:2015 http://dx.doi.org/10.1038/nature14177 Volltext http://urn.kb.se/resolve?urn=urn:nbn:se:du-17169 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_30 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_100 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_154 GBV_ILN_160 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_267 GBV_ILN_290 GBV_ILN_294 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2015 GBV_ILN_2016 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2095 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4700 AR 2015 |
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10.1038/nature14177 doi PQ20160617 (DE-627)OLC1962477916 (DE-599)GBVOLC1962477916 (PRQ)dalarna_diva_oai_DiVA_org_du_171690 (KEY)0072945020150000000000000000geneticstudiesofbodymassindexyieldnewinsightsforob DE-627 ger DE-627 rakwb eng 070 500 DNB 500 AVZ BIODIV fid Locke, Adam E verfasserin aut Genetic studies of body mass index yield new insights for obesity biology 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in upto 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 x 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for similar to 2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous systemin obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis. Nutzungsrecht: © info:eu-repo/semantics/restrictedAccess Kahali, Bratati oth Berndt, Sonja I oth Justice, Anne E oth Pers, Tune H oth Day, Felix R oth Powell, Corey oth Vedantam, Sailaja oth Buchkovich, Martin L oth Yang, Jian oth Croteau-Chonka, Damien C oth Esko, Tonu oth Fall, Tove oth Ferreira, Teresa oth Gustafsson, Stefan oth Kutalik, Zoltan oth Luan, Jian'an oth Maegi, Reedik oth Randall, Joshua C oth Winkler, Thomas W oth Wood, Andrew R oth Workalemahu, Tsegaselassie oth Faul, Jessica D oth Smith, Jennifer A oth Zhao, Jing Hua oth Zhao, Wei oth Chen, Jin oth Fehrmann, Rudolf oth Hedman, Asa K oth Karjalainen, Juha oth Schmidt, Ellen M oth Absher, Devin oth Amin, Najaf oth Anderson, Denise oth Beekman, Marian oth Bolton, Jennifer L oth Bragg-Gresham, L oth Buyske, Steven oth Demirkan, Ayse oth Deng, Guohong oth Ehret, Georg B oth Feenstra, Bjarke oth Feitosa, Mary F oth Fischer, Krista oth Goel, Anuj oth Gong, Jian oth Jackson, Anne U oth Kanoni, Stavroula oth Kleber, Marcus E oth Kristiansson, Kati oth Lim, Unhee oth Lotay, Vaneet oth Mangino, Massimo oth Leach, Irene Mateo oth Medina-Gomez, Carolina oth Medland, Sarah E oth Nalls, Michael A oth Palmer, Cameron D oth Pasko, Dorota oth Pechlivanis, Sonali oth Peters, Marjolein J oth Prokopenko, Inga oth Shungin, Dmitry oth Stancakova, Alena oth Strawbridge, Rona J oth Sung, Yun Ju oth Tanaka, Toshiko oth Teumer, Alexander oth Trompet, Stella oth van der Laan, Sander W oth van Settee, Jessica oth Van Vliet-Ostaptchouk, Jana V oth Wang, Zhaoming oth Yengo, Loic oth Zhang, Weihua oth Isaacs, Aaron oth Albrecht, Eva oth Ärnlöv, Johan oth Arscott, Gillian M oth Attwood, Antony P oth Bandinelli, Stefania oth Barrett, Amy oth Bas, Isabelita N oth Bellis, Claire oth Bennett, Amanda J oth Berne, Christian oth Blagieva, Roza oth Blueher, Matthias oth Bohringer, Stefan oth Bonnycastle, Lori L oth Boettcher, Yvonne oth Boyd, Heather A oth Bruinenberg, Marcel oth Caspersen, Ida H oth Chen, Yii-Der Ida oth Clarke, Robert oth Daw, E. Warwick oth de Craen, Anton J. M oth Delgado, Graciela oth Dimitriou, Maria oth ... oth Enthalten in Nature London : Macmillan Publishers Limited, part of Springer Nature, 1869 (2015) (DE-627)129292834 (DE-600)120714-3 (DE-576)014473941 0028-0836 nnns year:2015 http://dx.doi.org/10.1038/nature14177 Volltext http://urn.kb.se/resolve?urn=urn:nbn:se:du-17169 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_30 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_100 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_154 GBV_ILN_160 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_267 GBV_ILN_290 GBV_ILN_294 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2015 GBV_ILN_2016 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2095 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4700 AR 2015 |
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10.1038/nature14177 doi PQ20160617 (DE-627)OLC1962477916 (DE-599)GBVOLC1962477916 (PRQ)dalarna_diva_oai_DiVA_org_du_171690 (KEY)0072945020150000000000000000geneticstudiesofbodymassindexyieldnewinsightsforob DE-627 ger DE-627 rakwb eng 070 500 DNB 500 AVZ BIODIV fid Locke, Adam E verfasserin aut Genetic studies of body mass index yield new insights for obesity biology 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in upto 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 x 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for similar to 2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous systemin obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis. Nutzungsrecht: © info:eu-repo/semantics/restrictedAccess Kahali, Bratati oth Berndt, Sonja I oth Justice, Anne E oth Pers, Tune H oth Day, Felix R oth Powell, Corey oth Vedantam, Sailaja oth Buchkovich, Martin L oth Yang, Jian oth Croteau-Chonka, Damien C oth Esko, Tonu oth Fall, Tove oth Ferreira, Teresa oth Gustafsson, Stefan oth Kutalik, Zoltan oth Luan, Jian'an oth Maegi, Reedik oth Randall, Joshua C oth Winkler, Thomas W oth Wood, Andrew R oth Workalemahu, Tsegaselassie oth Faul, Jessica D oth Smith, Jennifer A oth Zhao, Jing Hua oth Zhao, Wei oth Chen, Jin oth Fehrmann, Rudolf oth Hedman, Asa K oth Karjalainen, Juha oth Schmidt, Ellen M oth Absher, Devin oth Amin, Najaf oth Anderson, Denise oth Beekman, Marian oth Bolton, Jennifer L oth Bragg-Gresham, L oth Buyske, Steven oth Demirkan, Ayse oth Deng, Guohong oth Ehret, Georg B oth Feenstra, Bjarke oth Feitosa, Mary F oth Fischer, Krista oth Goel, Anuj oth Gong, Jian oth Jackson, Anne U oth Kanoni, Stavroula oth Kleber, Marcus E oth Kristiansson, Kati oth Lim, Unhee oth Lotay, Vaneet oth Mangino, Massimo oth Leach, Irene Mateo oth Medina-Gomez, Carolina oth Medland, Sarah E oth Nalls, Michael A oth Palmer, Cameron D oth Pasko, Dorota oth Pechlivanis, Sonali oth Peters, Marjolein J oth Prokopenko, Inga oth Shungin, Dmitry oth Stancakova, Alena oth Strawbridge, Rona J oth Sung, Yun Ju oth Tanaka, Toshiko oth Teumer, Alexander oth Trompet, Stella oth van der Laan, Sander W oth van Settee, Jessica oth Van Vliet-Ostaptchouk, Jana V oth Wang, Zhaoming oth Yengo, Loic oth Zhang, Weihua oth Isaacs, Aaron oth Albrecht, Eva oth Ärnlöv, Johan oth Arscott, Gillian M oth Attwood, Antony P oth Bandinelli, Stefania oth Barrett, Amy oth Bas, Isabelita N oth Bellis, Claire oth Bennett, Amanda J oth Berne, Christian oth Blagieva, Roza oth Blueher, Matthias oth Bohringer, Stefan oth Bonnycastle, Lori L oth Boettcher, Yvonne oth Boyd, Heather A oth Bruinenberg, Marcel oth Caspersen, Ida H oth Chen, Yii-Der Ida oth Clarke, Robert oth Daw, E. Warwick oth de Craen, Anton J. M oth Delgado, Graciela oth Dimitriou, Maria oth ... oth Enthalten in Nature London : Macmillan Publishers Limited, part of Springer Nature, 1869 (2015) (DE-627)129292834 (DE-600)120714-3 (DE-576)014473941 0028-0836 nnns year:2015 http://dx.doi.org/10.1038/nature14177 Volltext http://urn.kb.se/resolve?urn=urn:nbn:se:du-17169 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_30 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_100 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_154 GBV_ILN_160 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_267 GBV_ILN_290 GBV_ILN_294 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2015 GBV_ILN_2016 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2095 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4700 AR 2015 |
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Locke, Adam E @@aut@@ Kahali, Bratati @@oth@@ Berndt, Sonja I @@oth@@ Justice, Anne E @@oth@@ Pers, Tune H @@oth@@ Day, Felix R @@oth@@ Powell, Corey @@oth@@ Vedantam, Sailaja @@oth@@ Buchkovich, Martin L @@oth@@ Yang, Jian @@oth@@ Croteau-Chonka, Damien C @@oth@@ Esko, Tonu @@oth@@ Fall, Tove @@oth@@ Ferreira, Teresa @@oth@@ Gustafsson, Stefan @@oth@@ Kutalik, Zoltan @@oth@@ Luan, Jian'an @@oth@@ Maegi, Reedik @@oth@@ Randall, Joshua C @@oth@@ Winkler, Thomas W @@oth@@ Wood, Andrew R @@oth@@ Workalemahu, Tsegaselassie @@oth@@ Faul, Jessica D @@oth@@ Smith, Jennifer A @@oth@@ Zhao, Jing Hua @@oth@@ Zhao, Wei @@oth@@ Chen, Jin @@oth@@ Fehrmann, Rudolf @@oth@@ Hedman, Asa K @@oth@@ Karjalainen, Juha @@oth@@ Schmidt, Ellen M @@oth@@ Absher, Devin @@oth@@ Amin, Najaf @@oth@@ Anderson, Denise @@oth@@ Beekman, Marian @@oth@@ Bolton, Jennifer L @@oth@@ Bragg-Gresham, L @@oth@@ Buyske, Steven @@oth@@ Demirkan, Ayse @@oth@@ Deng, Guohong @@oth@@ Ehret, Georg B @@oth@@ Feenstra, Bjarke @@oth@@ Feitosa, Mary F @@oth@@ Fischer, Krista @@oth@@ Goel, Anuj @@oth@@ Gong, Jian @@oth@@ Jackson, Anne U @@oth@@ Kanoni, Stavroula @@oth@@ Kleber, Marcus E @@oth@@ Kristiansson, Kati @@oth@@ Lim, Unhee @@oth@@ Lotay, Vaneet @@oth@@ Mangino, Massimo @@oth@@ Leach, Irene Mateo @@oth@@ Medina-Gomez, Carolina @@oth@@ Medland, Sarah E @@oth@@ Nalls, Michael A @@oth@@ Palmer, Cameron D @@oth@@ Pasko, Dorota @@oth@@ Pechlivanis, Sonali @@oth@@ Peters, Marjolein J @@oth@@ Prokopenko, Inga @@oth@@ Shungin, Dmitry @@oth@@ Stancakova, Alena @@oth@@ Strawbridge, Rona J @@oth@@ Sung, Yun Ju @@oth@@ Tanaka, Toshiko @@oth@@ Teumer, Alexander @@oth@@ Trompet, Stella @@oth@@ van der Laan, Sander W @@oth@@ van Settee, Jessica @@oth@@ Van Vliet-Ostaptchouk, Jana V @@oth@@ Wang, Zhaoming @@oth@@ Yengo, Loic @@oth@@ Zhang, Weihua @@oth@@ Isaacs, Aaron @@oth@@ Albrecht, Eva @@oth@@ Ärnlöv, Johan @@oth@@ Arscott, Gillian M @@oth@@ Attwood, Antony P @@oth@@ Bandinelli, Stefania @@oth@@ Barrett, Amy @@oth@@ Bas, Isabelita N @@oth@@ Bellis, Claire @@oth@@ Bennett, Amanda J @@oth@@ Berne, Christian @@oth@@ Blagieva, Roza @@oth@@ Blueher, Matthias @@oth@@ Bohringer, Stefan @@oth@@ Bonnycastle, Lori L @@oth@@ Boettcher, Yvonne @@oth@@ Boyd, Heather A @@oth@@ Bruinenberg, Marcel @@oth@@ Caspersen, Ida H @@oth@@ Chen, Yii-Der Ida @@oth@@ Clarke, Robert @@oth@@ Daw, E. Warwick @@oth@@ de Craen, Anton J. M @@oth@@ Delgado, Graciela @@oth@@ Dimitriou, Maria @@oth@@ ... @@oth@@ |
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Genetic studies of body mass index yield new insights for obesity biology |
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Genetic studies of body mass index yield new insights for obesity biology |
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genetic studies of body mass index yield new insights for obesity biology |
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Genetic studies of body mass index yield new insights for obesity biology |
| abstract |
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in upto 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 x 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for similar to 2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous systemin obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis. |
| abstractGer |
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in upto 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 x 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for similar to 2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous systemin obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis. |
| abstract_unstemmed |
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in upto 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 x 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for similar to 2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous systemin obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis. |
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| title_short |
Genetic studies of body mass index yield new insights for obesity biology |
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Kahali, Bratati Berndt, Sonja I Justice, Anne E Pers, Tune H Day, Felix R Powell, Corey Vedantam, Sailaja Buchkovich, Martin L Yang, Jian Croteau-Chonka, Damien C Esko, Tonu Fall, Tove Ferreira, Teresa Gustafsson, Stefan Kutalik, Zoltan Luan, Jian'an Maegi, Reedik Randall, Joshua C Winkler, Thomas W Wood, Andrew R Workalemahu, Tsegaselassie Faul, Jessica D Smith, Jennifer A Zhao, Jing Hua Zhao, Wei Chen, Jin Fehrmann, Rudolf Hedman, Asa K Karjalainen, Juha Schmidt, Ellen M Absher, Devin Amin, Najaf Anderson, Denise Beekman, Marian Bolton, Jennifer L Bragg-Gresham, L Buyske, Steven Demirkan, Ayse Deng, Guohong Ehret, Georg B Feenstra, Bjarke Feitosa, Mary F Fischer, Krista Goel, Anuj Gong, Jian Jackson, Anne U Kanoni, Stavroula Kleber, Marcus E Kristiansson, Kati Lim, Unhee Lotay, Vaneet Mangino, Massimo Leach, Irene Mateo Medina-Gomez, Carolina Medland, Sarah E Nalls, Michael A Palmer, Cameron D Pasko, Dorota Pechlivanis, Sonali Peters, Marjolein J Prokopenko, Inga Shungin, Dmitry Stancakova, Alena Strawbridge, Rona J Sung, Yun Ju Tanaka, Toshiko Teumer, Alexander Trompet, Stella van der Laan, Sander W van Settee, Jessica Van Vliet-Ostaptchouk, Jana V Wang, Zhaoming Yengo, Loic Zhang, Weihua Isaacs, Aaron Albrecht, Eva Ärnlöv, Johan Arscott, Gillian M Attwood, Antony P Bandinelli, Stefania Barrett, Amy Bas, Isabelita N Bellis, Claire Bennett, Amanda J Berne, Christian Blagieva, Roza Blueher, Matthias Bohringer, Stefan Bonnycastle, Lori L Boettcher, Yvonne Boyd, Heather A Bruinenberg, Marcel Caspersen, Ida H Chen, Yii-Der Ida Clarke, Robert Daw, E. Warwick de Craen, Anton J. M Delgado, Graciela Dimitriou, Maria . |
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Kahali, Bratati Berndt, Sonja I Justice, Anne E Pers, Tune H Day, Felix R Powell, Corey Vedantam, Sailaja Buchkovich, Martin L Yang, Jian Croteau-Chonka, Damien C Esko, Tonu Fall, Tove Ferreira, Teresa Gustafsson, Stefan Kutalik, Zoltan Luan, Jian'an Maegi, Reedik Randall, Joshua C Winkler, Thomas W Wood, Andrew R Workalemahu, Tsegaselassie Faul, Jessica D Smith, Jennifer A Zhao, Jing Hua Zhao, Wei Chen, Jin Fehrmann, Rudolf Hedman, Asa K Karjalainen, Juha Schmidt, Ellen M Absher, Devin Amin, Najaf Anderson, Denise Beekman, Marian Bolton, Jennifer L Bragg-Gresham, L Buyske, Steven Demirkan, Ayse Deng, Guohong Ehret, Georg B Feenstra, Bjarke Feitosa, Mary F Fischer, Krista Goel, Anuj Gong, Jian Jackson, Anne U Kanoni, Stavroula Kleber, Marcus E Kristiansson, Kati Lim, Unhee Lotay, Vaneet Mangino, Massimo Leach, Irene Mateo Medina-Gomez, Carolina Medland, Sarah E Nalls, Michael A Palmer, Cameron D Pasko, Dorota Pechlivanis, Sonali Peters, Marjolein J Prokopenko, Inga Shungin, Dmitry Stancakova, Alena Strawbridge, Rona J Sung, Yun Ju Tanaka, Toshiko Teumer, Alexander Trompet, Stella van der Laan, Sander W van Settee, Jessica Van Vliet-Ostaptchouk, Jana V Wang, Zhaoming Yengo, Loic Zhang, Weihua Isaacs, Aaron Albrecht, Eva Ärnlöv, Johan Arscott, Gillian M Attwood, Antony P Bandinelli, Stefania Barrett, Amy Bas, Isabelita N Bellis, Claire Bennett, Amanda J Berne, Christian Blagieva, Roza Blueher, Matthias Bohringer, Stefan Bonnycastle, Lori L Boettcher, Yvonne Boyd, Heather A Bruinenberg, Marcel Caspersen, Ida H Chen, Yii-Der Ida Clarke, Robert Daw, E. Warwick de Craen, Anton J. M Delgado, Graciela Dimitriou, Maria . |
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