New genetic loci link adipose and insulin biology to body fat distribution
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide asso...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Shungin, Dmitry [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Übergeordnetes Werk: |
Enthalten in: Nature - London : Macmillan Publishers Limited, part of Springer Nature, 1869, 518(2015), 7538, Seite 187 |
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| Übergeordnetes Werk: |
volume:518 ; year:2015 ; number:7538 ; pages:187 |
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| 520 | |a Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms. | ||
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PQ20160617 (DE-627)OLC1962478785 (DE-599)GBVOLC1962478785 (PRQ)swepub_primary_oai_DiVA_org_uu_2442670 (KEY)0072945020150000518753800187newgeneticlocilinkadiposeandinsulinbiologytobodyfa DE-627 ger DE-627 rakwb eng 070 500 DNB 500 AVZ BIODIV fid Shungin, Dmitry verfasserin aut New genetic loci link adipose and insulin biology to body fat distribution 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms. Winkler, Thomas W oth Croteau-Chonka, Damien C oth Ferreira, Teresa oth Locke, Adam E oth Mägi, Reedik oth Strawbridge, Rona J oth Pers, Tune H oth Fischer, Krista oth Justice, Anne E oth Workalemahu, Tsegaselassie oth Wu, Joseph M W oth Buchkovich, Martin L oth Heard-Costa, Nancy L oth Roman, Tamara S oth Drong, Alexander W oth Song, Ci oth Gustafsson, Stefan oth Day, Felix R oth Esko, Tonu oth Fall, Tove oth Kutalik, Zoltán oth Luan, Jian'an oth Randall, Joshua C oth Scherag, André oth Vedantam, Sailaja oth Wood, Andrew R oth Chen, Jin oth Fehrmann, Rudolf oth Karjalainen, Juha oth Kahali, Bratati oth Liu, Ching-Ti oth Schmidt, Ellen M oth Absher, Devin oth Amin, Najaf oth Anderson, Denise oth Beekman, Marian oth Bragg-Gresham, Jennifer L oth Buyske, Steven oth Demirkan, Ayse oth Ehret, Georg B oth Feitosa, Mary F oth Goel, Anuj oth Jackson, Anne U oth Johnson, Toby oth Kleber, Marcus E oth Kristiansson, Kati oth Mangino, Massimo oth Mateo Leach, Irene oth Medina-Gomez, Carolina oth Palmer, Cameron D oth Pasko, Dorota oth Pechlivanis, Sonali oth Peters, Marjolein J oth Prokopenko, Inga oth Stančáková, Alena oth Ju Sung, Yun oth Tanaka, Toshiko oth Teumer, Alexander oth Van Vliet-Ostaptchouk, Jana V oth Yengo, Loïc oth Zhang, Weihua oth Albrecht, Eva oth Ärnlöv, Johan oth Arscott, Gillian M oth Bandinelli, Stefania oth Barrett, Amy oth Bellis, Claire oth Bennett, Amanda J oth Berne, Christian oth Blüher, Matthias oth Böhringer, Stefan oth Bonnet, Fabrice oth Böttcher, Yvonne oth Bruinenberg, Marcel oth Carba, Delia B oth Caspersen, Ida H oth Clarke, Robert oth Daw, E Warwick oth Deelen, Joris oth Deelman, Ewa oth Delgado, Graciela oth Doney, Alex S F oth Eklund, Niina oth Erdos, Michael R oth Estrada, Karol oth Eury, Elodie oth Friedrich, Nele oth Garcia, Melissa E oth Giedraitis, Vilmantas oth Gigante, Bruna oth Go, Alan S oth Golay, Alain oth Grallert, Harald oth Grammer, Tanja B oth Gräßler, Jürgen oth Grewal, Jagvir oth Groves, Christopher J oth Haller, Toomas oth Hallmans, Goran oth ... oth Enthalten in Nature London : Macmillan Publishers Limited, part of Springer Nature, 1869 518(2015), 7538, Seite 187 (DE-627)129292834 (DE-600)120714-3 (DE-576)014473941 0028-0836 nnns volume:518 year:2015 number:7538 pages:187 http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-244267 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_30 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_100 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_154 GBV_ILN_160 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_267 GBV_ILN_290 GBV_ILN_294 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2015 GBV_ILN_2016 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2095 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4700 AR 518 2015 7538 187 |
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PQ20160617 (DE-627)OLC1962478785 (DE-599)GBVOLC1962478785 (PRQ)swepub_primary_oai_DiVA_org_uu_2442670 (KEY)0072945020150000518753800187newgeneticlocilinkadiposeandinsulinbiologytobodyfa DE-627 ger DE-627 rakwb eng 070 500 DNB 500 AVZ BIODIV fid Shungin, Dmitry verfasserin aut New genetic loci link adipose and insulin biology to body fat distribution 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms. Winkler, Thomas W oth Croteau-Chonka, Damien C oth Ferreira, Teresa oth Locke, Adam E oth Mägi, Reedik oth Strawbridge, Rona J oth Pers, Tune H oth Fischer, Krista oth Justice, Anne E oth Workalemahu, Tsegaselassie oth Wu, Joseph M W oth Buchkovich, Martin L oth Heard-Costa, Nancy L oth Roman, Tamara S oth Drong, Alexander W oth Song, Ci oth Gustafsson, Stefan oth Day, Felix R oth Esko, Tonu oth Fall, Tove oth Kutalik, Zoltán oth Luan, Jian'an oth Randall, Joshua C oth Scherag, André oth Vedantam, Sailaja oth Wood, Andrew R oth Chen, Jin oth Fehrmann, Rudolf oth Karjalainen, Juha oth Kahali, Bratati oth Liu, Ching-Ti oth Schmidt, Ellen M oth Absher, Devin oth Amin, Najaf oth Anderson, Denise oth Beekman, Marian oth Bragg-Gresham, Jennifer L oth Buyske, Steven oth Demirkan, Ayse oth Ehret, Georg B oth Feitosa, Mary F oth Goel, Anuj oth Jackson, Anne U oth Johnson, Toby oth Kleber, Marcus E oth Kristiansson, Kati oth Mangino, Massimo oth Mateo Leach, Irene oth Medina-Gomez, Carolina oth Palmer, Cameron D oth Pasko, Dorota oth Pechlivanis, Sonali oth Peters, Marjolein J oth Prokopenko, Inga oth Stančáková, Alena oth Ju Sung, Yun oth Tanaka, Toshiko oth Teumer, Alexander oth Van Vliet-Ostaptchouk, Jana V oth Yengo, Loïc oth Zhang, Weihua oth Albrecht, Eva oth Ärnlöv, Johan oth Arscott, Gillian M oth Bandinelli, Stefania oth Barrett, Amy oth Bellis, Claire oth Bennett, Amanda J oth Berne, Christian oth Blüher, Matthias oth Böhringer, Stefan oth Bonnet, Fabrice oth Böttcher, Yvonne oth Bruinenberg, Marcel oth Carba, Delia B oth Caspersen, Ida H oth Clarke, Robert oth Daw, E Warwick oth Deelen, Joris oth Deelman, Ewa oth Delgado, Graciela oth Doney, Alex S F oth Eklund, Niina oth Erdos, Michael R oth Estrada, Karol oth Eury, Elodie oth Friedrich, Nele oth Garcia, Melissa E oth Giedraitis, Vilmantas oth Gigante, Bruna oth Go, Alan S oth Golay, Alain oth Grallert, Harald oth Grammer, Tanja B oth Gräßler, Jürgen oth Grewal, Jagvir oth Groves, Christopher J oth Haller, Toomas oth Hallmans, Goran oth ... oth Enthalten in Nature London : Macmillan Publishers Limited, part of Springer Nature, 1869 518(2015), 7538, Seite 187 (DE-627)129292834 (DE-600)120714-3 (DE-576)014473941 0028-0836 nnns volume:518 year:2015 number:7538 pages:187 http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-244267 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_30 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_100 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_154 GBV_ILN_160 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_267 GBV_ILN_290 GBV_ILN_294 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2015 GBV_ILN_2016 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2095 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4700 AR 518 2015 7538 187 |
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PQ20160617 (DE-627)OLC1962478785 (DE-599)GBVOLC1962478785 (PRQ)swepub_primary_oai_DiVA_org_uu_2442670 (KEY)0072945020150000518753800187newgeneticlocilinkadiposeandinsulinbiologytobodyfa DE-627 ger DE-627 rakwb eng 070 500 DNB 500 AVZ BIODIV fid Shungin, Dmitry verfasserin aut New genetic loci link adipose and insulin biology to body fat distribution 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms. Winkler, Thomas W oth Croteau-Chonka, Damien C oth Ferreira, Teresa oth Locke, Adam E oth Mägi, Reedik oth Strawbridge, Rona J oth Pers, Tune H oth Fischer, Krista oth Justice, Anne E oth Workalemahu, Tsegaselassie oth Wu, Joseph M W oth Buchkovich, Martin L oth Heard-Costa, Nancy L oth Roman, Tamara S oth Drong, Alexander W oth Song, Ci oth Gustafsson, Stefan oth Day, Felix R oth Esko, Tonu oth Fall, Tove oth Kutalik, Zoltán oth Luan, Jian'an oth Randall, Joshua C oth Scherag, André oth Vedantam, Sailaja oth Wood, Andrew R oth Chen, Jin oth Fehrmann, Rudolf oth Karjalainen, Juha oth Kahali, Bratati oth Liu, Ching-Ti oth Schmidt, Ellen M oth Absher, Devin oth Amin, Najaf oth Anderson, Denise oth Beekman, Marian oth Bragg-Gresham, Jennifer L oth Buyske, Steven oth Demirkan, Ayse oth Ehret, Georg B oth Feitosa, Mary F oth Goel, Anuj oth Jackson, Anne U oth Johnson, Toby oth Kleber, Marcus E oth Kristiansson, Kati oth Mangino, Massimo oth Mateo Leach, Irene oth Medina-Gomez, Carolina oth Palmer, Cameron D oth Pasko, Dorota oth Pechlivanis, Sonali oth Peters, Marjolein J oth Prokopenko, Inga oth Stančáková, Alena oth Ju Sung, Yun oth Tanaka, Toshiko oth Teumer, Alexander oth Van Vliet-Ostaptchouk, Jana V oth Yengo, Loïc oth Zhang, Weihua oth Albrecht, Eva oth Ärnlöv, Johan oth Arscott, Gillian M oth Bandinelli, Stefania oth Barrett, Amy oth Bellis, Claire oth Bennett, Amanda J oth Berne, Christian oth Blüher, Matthias oth Böhringer, Stefan oth Bonnet, Fabrice oth Böttcher, Yvonne oth Bruinenberg, Marcel oth Carba, Delia B oth Caspersen, Ida H oth Clarke, Robert oth Daw, E Warwick oth Deelen, Joris oth Deelman, Ewa oth Delgado, Graciela oth Doney, Alex S F oth Eklund, Niina oth Erdos, Michael R oth Estrada, Karol oth Eury, Elodie oth Friedrich, Nele oth Garcia, Melissa E oth Giedraitis, Vilmantas oth Gigante, Bruna oth Go, Alan S oth Golay, Alain oth Grallert, Harald oth Grammer, Tanja B oth Gräßler, Jürgen oth Grewal, Jagvir oth Groves, Christopher J oth Haller, Toomas oth Hallmans, Goran oth ... oth Enthalten in Nature London : Macmillan Publishers Limited, part of Springer Nature, 1869 518(2015), 7538, Seite 187 (DE-627)129292834 (DE-600)120714-3 (DE-576)014473941 0028-0836 nnns volume:518 year:2015 number:7538 pages:187 http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-244267 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_30 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_100 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_154 GBV_ILN_160 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_267 GBV_ILN_290 GBV_ILN_294 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2015 GBV_ILN_2016 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2095 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4700 AR 518 2015 7538 187 |
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PQ20160617 (DE-627)OLC1962478785 (DE-599)GBVOLC1962478785 (PRQ)swepub_primary_oai_DiVA_org_uu_2442670 (KEY)0072945020150000518753800187newgeneticlocilinkadiposeandinsulinbiologytobodyfa DE-627 ger DE-627 rakwb eng 070 500 DNB 500 AVZ BIODIV fid Shungin, Dmitry verfasserin aut New genetic loci link adipose and insulin biology to body fat distribution 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms. Winkler, Thomas W oth Croteau-Chonka, Damien C oth Ferreira, Teresa oth Locke, Adam E oth Mägi, Reedik oth Strawbridge, Rona J oth Pers, Tune H oth Fischer, Krista oth Justice, Anne E oth Workalemahu, Tsegaselassie oth Wu, Joseph M W oth Buchkovich, Martin L oth Heard-Costa, Nancy L oth Roman, Tamara S oth Drong, Alexander W oth Song, Ci oth Gustafsson, Stefan oth Day, Felix R oth Esko, Tonu oth Fall, Tove oth Kutalik, Zoltán oth Luan, Jian'an oth Randall, Joshua C oth Scherag, André oth Vedantam, Sailaja oth Wood, Andrew R oth Chen, Jin oth Fehrmann, Rudolf oth Karjalainen, Juha oth Kahali, Bratati oth Liu, Ching-Ti oth Schmidt, Ellen M oth Absher, Devin oth Amin, Najaf oth Anderson, Denise oth Beekman, Marian oth Bragg-Gresham, Jennifer L oth Buyske, Steven oth Demirkan, Ayse oth Ehret, Georg B oth Feitosa, Mary F oth Goel, Anuj oth Jackson, Anne U oth Johnson, Toby oth Kleber, Marcus E oth Kristiansson, Kati oth Mangino, Massimo oth Mateo Leach, Irene oth Medina-Gomez, Carolina oth Palmer, Cameron D oth Pasko, Dorota oth Pechlivanis, Sonali oth Peters, Marjolein J oth Prokopenko, Inga oth Stančáková, Alena oth Ju Sung, Yun oth Tanaka, Toshiko oth Teumer, Alexander oth Van Vliet-Ostaptchouk, Jana V oth Yengo, Loïc oth Zhang, Weihua oth Albrecht, Eva oth Ärnlöv, Johan oth Arscott, Gillian M oth Bandinelli, Stefania oth Barrett, Amy oth Bellis, Claire oth Bennett, Amanda J oth Berne, Christian oth Blüher, Matthias oth Böhringer, Stefan oth Bonnet, Fabrice oth Böttcher, Yvonne oth Bruinenberg, Marcel oth Carba, Delia B oth Caspersen, Ida H oth Clarke, Robert oth Daw, E Warwick oth Deelen, Joris oth Deelman, Ewa oth Delgado, Graciela oth Doney, Alex S F oth Eklund, Niina oth Erdos, Michael R oth Estrada, Karol oth Eury, Elodie oth Friedrich, Nele oth Garcia, Melissa E oth Giedraitis, Vilmantas oth Gigante, Bruna oth Go, Alan S oth Golay, Alain oth Grallert, Harald oth Grammer, Tanja B oth Gräßler, Jürgen oth Grewal, Jagvir oth Groves, Christopher J oth Haller, Toomas oth Hallmans, Goran oth ... oth Enthalten in Nature London : Macmillan Publishers Limited, part of Springer Nature, 1869 518(2015), 7538, Seite 187 (DE-627)129292834 (DE-600)120714-3 (DE-576)014473941 0028-0836 nnns volume:518 year:2015 number:7538 pages:187 http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-244267 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_30 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_100 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_154 GBV_ILN_160 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_267 GBV_ILN_290 GBV_ILN_294 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2015 GBV_ILN_2016 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2095 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4700 AR 518 2015 7538 187 |
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Shungin, Dmitry @@aut@@ Winkler, Thomas W @@oth@@ Croteau-Chonka, Damien C @@oth@@ Ferreira, Teresa @@oth@@ Locke, Adam E @@oth@@ Mägi, Reedik @@oth@@ Strawbridge, Rona J @@oth@@ Pers, Tune H @@oth@@ Fischer, Krista @@oth@@ Justice, Anne E @@oth@@ Workalemahu, Tsegaselassie @@oth@@ Wu, Joseph M W @@oth@@ Buchkovich, Martin L @@oth@@ Heard-Costa, Nancy L @@oth@@ Roman, Tamara S @@oth@@ Drong, Alexander W @@oth@@ Song, Ci @@oth@@ Gustafsson, Stefan @@oth@@ Day, Felix R @@oth@@ Esko, Tonu @@oth@@ Fall, Tove @@oth@@ Kutalik, Zoltán @@oth@@ Luan, Jian'an @@oth@@ Randall, Joshua C @@oth@@ Scherag, André @@oth@@ Vedantam, Sailaja @@oth@@ Wood, Andrew R @@oth@@ Chen, Jin @@oth@@ Fehrmann, Rudolf @@oth@@ Karjalainen, Juha @@oth@@ Kahali, Bratati @@oth@@ Liu, Ching-Ti @@oth@@ Schmidt, Ellen M @@oth@@ Absher, Devin @@oth@@ Amin, Najaf @@oth@@ Anderson, Denise @@oth@@ Beekman, Marian @@oth@@ Bragg-Gresham, Jennifer L @@oth@@ Buyske, Steven @@oth@@ Demirkan, Ayse @@oth@@ Ehret, Georg B @@oth@@ Feitosa, Mary F @@oth@@ Goel, Anuj @@oth@@ Jackson, Anne U @@oth@@ Johnson, Toby @@oth@@ Kleber, Marcus E @@oth@@ Kristiansson, Kati @@oth@@ Mangino, Massimo @@oth@@ Mateo Leach, Irene @@oth@@ Medina-Gomez, Carolina @@oth@@ Palmer, Cameron D @@oth@@ Pasko, Dorota @@oth@@ Pechlivanis, Sonali @@oth@@ Peters, Marjolein J @@oth@@ Prokopenko, Inga @@oth@@ Stančáková, Alena @@oth@@ Ju Sung, Yun @@oth@@ Tanaka, Toshiko @@oth@@ Teumer, Alexander @@oth@@ Van Vliet-Ostaptchouk, Jana V @@oth@@ Yengo, Loïc @@oth@@ Zhang, Weihua @@oth@@ Albrecht, Eva @@oth@@ Ärnlöv, Johan @@oth@@ Arscott, Gillian M @@oth@@ Bandinelli, Stefania @@oth@@ Barrett, Amy @@oth@@ Bellis, Claire @@oth@@ Bennett, Amanda J @@oth@@ Berne, Christian @@oth@@ Blüher, Matthias @@oth@@ Böhringer, Stefan @@oth@@ Bonnet, Fabrice @@oth@@ Böttcher, Yvonne @@oth@@ Bruinenberg, Marcel @@oth@@ Carba, Delia B @@oth@@ Caspersen, Ida H @@oth@@ Clarke, Robert @@oth@@ Daw, E Warwick @@oth@@ Deelen, Joris @@oth@@ Deelman, Ewa @@oth@@ Delgado, Graciela @@oth@@ Doney, Alex S F @@oth@@ Eklund, Niina @@oth@@ Erdos, Michael R @@oth@@ Estrada, Karol @@oth@@ Eury, Elodie @@oth@@ Friedrich, Nele @@oth@@ Garcia, Melissa E @@oth@@ Giedraitis, Vilmantas @@oth@@ Gigante, Bruna @@oth@@ Go, Alan S @@oth@@ Golay, Alain @@oth@@ Grallert, Harald @@oth@@ Grammer, Tanja B @@oth@@ Gräßler, Jürgen @@oth@@ Grewal, Jagvir @@oth@@ Groves, Christopher J @@oth@@ Haller, Toomas @@oth@@ Hallmans, Goran @@oth@@ ... @@oth@@ |
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| author |
Shungin, Dmitry |
| spellingShingle |
Shungin, Dmitry ddc 070 ddc 500 fid BIODIV New genetic loci link adipose and insulin biology to body fat distribution |
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070 500 DNB 500 AVZ BIODIV fid New genetic loci link adipose and insulin biology to body fat distribution |
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ddc 070 ddc 500 fid BIODIV |
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| title |
New genetic loci link adipose and insulin biology to body fat distribution |
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(DE-627)OLC1962478785 (DE-599)GBVOLC1962478785 (PRQ)swepub_primary_oai_DiVA_org_uu_2442670 (KEY)0072945020150000518753800187newgeneticlocilinkadiposeandinsulinbiologytobodyfa |
| title_full |
New genetic loci link adipose and insulin biology to body fat distribution |
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Shungin, Dmitry |
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Nature |
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eng |
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000 - Computer science, information & general works 500 - Science |
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Shungin, Dmitry |
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Shungin, Dmitry |
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070 500 |
| title_sort |
new genetic loci link adipose and insulin biology to body fat distribution |
| title_auth |
New genetic loci link adipose and insulin biology to body fat distribution |
| abstract |
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms. |
| abstractGer |
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms. |
| abstract_unstemmed |
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms. |
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New genetic loci link adipose and insulin biology to body fat distribution |
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Winkler, Thomas W Croteau-Chonka, Damien C Ferreira, Teresa Locke, Adam E Mägi, Reedik Strawbridge, Rona J Pers, Tune H Fischer, Krista Justice, Anne E Workalemahu, Tsegaselassie Wu, Joseph M W Buchkovich, Martin L Heard-Costa, Nancy L Roman, Tamara S Drong, Alexander W Song, Ci Gustafsson, Stefan Day, Felix R Esko, Tonu Fall, Tove Kutalik, Zoltán Luan, Jian'an Randall, Joshua C Scherag, André Vedantam, Sailaja Wood, Andrew R Chen, Jin Fehrmann, Rudolf Karjalainen, Juha Kahali, Bratati Liu, Ching-Ti Schmidt, Ellen M Absher, Devin Amin, Najaf Anderson, Denise Beekman, Marian Bragg-Gresham, Jennifer L Buyske, Steven Demirkan, Ayse Ehret, Georg B Feitosa, Mary F Goel, Anuj Jackson, Anne U Johnson, Toby Kleber, Marcus E Kristiansson, Kati Mangino, Massimo Mateo Leach, Irene Medina-Gomez, Carolina Palmer, Cameron D Pasko, Dorota Pechlivanis, Sonali Peters, Marjolein J Prokopenko, Inga Stančáková, Alena Ju Sung, Yun Tanaka, Toshiko Teumer, Alexander Van Vliet-Ostaptchouk, Jana V Yengo, Loïc Zhang, Weihua Albrecht, Eva Ärnlöv, Johan Arscott, Gillian M Bandinelli, Stefania Barrett, Amy Bellis, Claire Bennett, Amanda J Berne, Christian Blüher, Matthias Böhringer, Stefan Bonnet, Fabrice Böttcher, Yvonne Bruinenberg, Marcel Carba, Delia B Caspersen, Ida H Clarke, Robert Daw, E Warwick Deelen, Joris Deelman, Ewa Delgado, Graciela Doney, Alex S F Eklund, Niina Erdos, Michael R Estrada, Karol Eury, Elodie Friedrich, Nele Garcia, Melissa E Giedraitis, Vilmantas Gigante, Bruna Go, Alan S Golay, Alain Grallert, Harald Grammer, Tanja B Gräßler, Jürgen Grewal, Jagvir Groves, Christopher J Haller, Toomas Hallmans, Goran . |
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Winkler, Thomas W Croteau-Chonka, Damien C Ferreira, Teresa Locke, Adam E Mägi, Reedik Strawbridge, Rona J Pers, Tune H Fischer, Krista Justice, Anne E Workalemahu, Tsegaselassie Wu, Joseph M W Buchkovich, Martin L Heard-Costa, Nancy L Roman, Tamara S Drong, Alexander W Song, Ci Gustafsson, Stefan Day, Felix R Esko, Tonu Fall, Tove Kutalik, Zoltán Luan, Jian'an Randall, Joshua C Scherag, André Vedantam, Sailaja Wood, Andrew R Chen, Jin Fehrmann, Rudolf Karjalainen, Juha Kahali, Bratati Liu, Ching-Ti Schmidt, Ellen M Absher, Devin Amin, Najaf Anderson, Denise Beekman, Marian Bragg-Gresham, Jennifer L Buyske, Steven Demirkan, Ayse Ehret, Georg B Feitosa, Mary F Goel, Anuj Jackson, Anne U Johnson, Toby Kleber, Marcus E Kristiansson, Kati Mangino, Massimo Mateo Leach, Irene Medina-Gomez, Carolina Palmer, Cameron D Pasko, Dorota Pechlivanis, Sonali Peters, Marjolein J Prokopenko, Inga Stančáková, Alena Ju Sung, Yun Tanaka, Toshiko Teumer, Alexander Van Vliet-Ostaptchouk, Jana V Yengo, Loïc Zhang, Weihua Albrecht, Eva Ärnlöv, Johan Arscott, Gillian M Bandinelli, Stefania Barrett, Amy Bellis, Claire Bennett, Amanda J Berne, Christian Blüher, Matthias Böhringer, Stefan Bonnet, Fabrice Böttcher, Yvonne Bruinenberg, Marcel Carba, Delia B Caspersen, Ida H Clarke, Robert Daw, E Warwick Deelen, Joris Deelman, Ewa Delgado, Graciela Doney, Alex S F Eklund, Niina Erdos, Michael R Estrada, Karol Eury, Elodie Friedrich, Nele Garcia, Melissa E Giedraitis, Vilmantas Gigante, Bruna Go, Alan S Golay, Alain Grallert, Harald Grammer, Tanja B Gräßler, Jürgen Grewal, Jagvir Groves, Christopher J Haller, Toomas Hallmans, Goran . |
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