Phenolic metabolites of anthocyanins modulate mechanisms of endothelial function
Anthocyanins are reported to have vascular bioactivity, however their mechanisms of action are largely unknown. Evidence suggests that anthocyanins modulate endothelial function, potentially by increasing nitric oxide (NO) synthesis, or enhancing NO bioavailability. This study compared the activity...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Edwards, Michael [verfasserIn] |
|---|
| Format: |
Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2015 |
|---|
| Schlagwörter: |
Human Umbilical Vein Endothelial Cells - metabolism |
|---|
| Übergeordnetes Werk: |
Enthalten in: Journal of agricultural and food chemistry - Columbus, Ohio : American Chemical Soc., 1953, 63(2015), 9, Seite 2423 |
|---|---|
| Übergeordnetes Werk: |
volume:63 ; year:2015 ; number:9 ; pages:2423 |
| Links: |
|---|
| Katalog-ID: |
OLC1963006895 |
|---|
| LEADER | 01000caa a2200265 4500 | ||
|---|---|---|---|
| 001 | OLC1963006895 | ||
| 003 | DE-627 | ||
| 005 | 20230513021844.0 | ||
| 007 | tu | ||
| 008 | 160206s2015 xx ||||| 00| ||eng c | ||
| 028 | 5 | 2 | |a PQ20160617 |
| 035 | |a (DE-627)OLC1963006895 | ||
| 035 | |a (DE-599)GBVOLC1963006895 | ||
| 035 | |a (PRQ)p838-e237ad9418a80dbf7f599890832600e08ce9fcf20d06323f772208f5403df34f0 | ||
| 035 | |a (KEY)0011841920150000063000902423phenolicmetabolitesofanthocyaninsmodulatemechanism | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 630 |a 640 |a 540 |q DNB |
| 084 | |a 58.27 |2 bkl | ||
| 084 | |a 58.34 |2 bkl | ||
| 084 | |a 42.63 |2 bkl | ||
| 100 | 1 | |a Edwards, Michael |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Phenolic metabolites of anthocyanins modulate mechanisms of endothelial function |
| 264 | 1 | |c 2015 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 520 | |a Anthocyanins are reported to have vascular bioactivity, however their mechanisms of action are largely unknown. Evidence suggests that anthocyanins modulate endothelial function, potentially by increasing nitric oxide (NO) synthesis, or enhancing NO bioavailability. This study compared the activity of cyanidin-3-glucoside, its degradation product protocatechuic acid, and phase II metabolite, vanillic acid. Production of NO and superoxide and expression of endothelial NO synthase (eNOS), NADPH oxidase (NOX), and heme oxygenase-1 (HO-1) were established in human vascular cell models. Nitric oxide levels were not modulated by the treatments, although eNOS was upregulated by cyanidin-3-glucoside, and superoxide production was decreased by both phenolic acids. Vanillic acid upregulated p22(phox) mRNA but did not alter NOX protein expression, although trends were observed for p47(phox) downregulation and HO-1 upregulation. Anthocyanin metabolites may therefore modulate vascular reactivity by inducing HO-1 and modulating NOX activity, resulting in reduced superoxide production and improved NO bioavailability. | ||
| 650 | 4 | |a Anthocyanins - metabolism | |
| 650 | 4 | |a Human Umbilical Vein Endothelial Cells - metabolism | |
| 650 | 4 | |a Nitric Oxide Synthase Type III - metabolism | |
| 650 | 4 | |a Superoxides - metabolism | |
| 650 | 4 | |a Nitric Oxide - metabolism | |
| 650 | 4 | |a Phenols - metabolism | |
| 700 | 1 | |a Czank, Charles |4 oth | |
| 700 | 1 | |a Woodward, Gary M |4 oth | |
| 700 | 1 | |a Cassidy, Aedín |4 oth | |
| 700 | 1 | |a Kay, Colin D |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of agricultural and food chemistry |d Columbus, Ohio : American Chemical Soc., 1953 |g 63(2015), 9, Seite 2423 |w (DE-627)129602795 |w (DE-600)241619-0 |w (DE-576)015096610 |x 0021-8561 |7 nnns |
| 773 | 1 | 8 | |g volume:63 |g year:2015 |g number:9 |g pages:2423 |
| 856 | 4 | 2 | |u http://www.ncbi.nlm.nih.gov/pubmed/25686009 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_OLC | ||
| 912 | |a SSG-OLC-TEC | ||
| 912 | |a SSG-OLC-CHE | ||
| 912 | |a SSG-OLC-PHA | ||
| 912 | |a SSG-OLC-DE-84 | ||
| 912 | |a SSG-OPC-FOR | ||
| 912 | |a GBV_ILN_70 | ||
| 912 | |a GBV_ILN_2006 | ||
| 912 | |a GBV_ILN_4219 | ||
| 936 | b | k | |a 58.27 |q AVZ |
| 936 | b | k | |a 58.34 |q AVZ |
| 936 | b | k | |a 42.63 |q AVZ |
| 951 | |a AR | ||
| 952 | |d 63 |j 2015 |e 9 |h 2423 | ||
| author_variant |
m e me |
|---|---|
| matchkey_str |
article:00218561:2015----::hnlceaoieoatoynnmdltmcaimoe |
| hierarchy_sort_str |
2015 |
| bklnumber |
58.27 58.34 42.63 |
| publishDate |
2015 |
| allfields |
PQ20160617 (DE-627)OLC1963006895 (DE-599)GBVOLC1963006895 (PRQ)p838-e237ad9418a80dbf7f599890832600e08ce9fcf20d06323f772208f5403df34f0 (KEY)0011841920150000063000902423phenolicmetabolitesofanthocyaninsmodulatemechanism DE-627 ger DE-627 rakwb eng 630 640 540 DNB 58.27 bkl 58.34 bkl 42.63 bkl Edwards, Michael verfasserin aut Phenolic metabolites of anthocyanins modulate mechanisms of endothelial function 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Anthocyanins are reported to have vascular bioactivity, however their mechanisms of action are largely unknown. Evidence suggests that anthocyanins modulate endothelial function, potentially by increasing nitric oxide (NO) synthesis, or enhancing NO bioavailability. This study compared the activity of cyanidin-3-glucoside, its degradation product protocatechuic acid, and phase II metabolite, vanillic acid. Production of NO and superoxide and expression of endothelial NO synthase (eNOS), NADPH oxidase (NOX), and heme oxygenase-1 (HO-1) were established in human vascular cell models. Nitric oxide levels were not modulated by the treatments, although eNOS was upregulated by cyanidin-3-glucoside, and superoxide production was decreased by both phenolic acids. Vanillic acid upregulated p22(phox) mRNA but did not alter NOX protein expression, although trends were observed for p47(phox) downregulation and HO-1 upregulation. Anthocyanin metabolites may therefore modulate vascular reactivity by inducing HO-1 and modulating NOX activity, resulting in reduced superoxide production and improved NO bioavailability. Anthocyanins - metabolism Human Umbilical Vein Endothelial Cells - metabolism Nitric Oxide Synthase Type III - metabolism Superoxides - metabolism Nitric Oxide - metabolism Phenols - metabolism Czank, Charles oth Woodward, Gary M oth Cassidy, Aedín oth Kay, Colin D oth Enthalten in Journal of agricultural and food chemistry Columbus, Ohio : American Chemical Soc., 1953 63(2015), 9, Seite 2423 (DE-627)129602795 (DE-600)241619-0 (DE-576)015096610 0021-8561 nnns volume:63 year:2015 number:9 pages:2423 http://www.ncbi.nlm.nih.gov/pubmed/25686009 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_70 GBV_ILN_2006 GBV_ILN_4219 58.27 AVZ 58.34 AVZ 42.63 AVZ AR 63 2015 9 2423 |
| spelling |
PQ20160617 (DE-627)OLC1963006895 (DE-599)GBVOLC1963006895 (PRQ)p838-e237ad9418a80dbf7f599890832600e08ce9fcf20d06323f772208f5403df34f0 (KEY)0011841920150000063000902423phenolicmetabolitesofanthocyaninsmodulatemechanism DE-627 ger DE-627 rakwb eng 630 640 540 DNB 58.27 bkl 58.34 bkl 42.63 bkl Edwards, Michael verfasserin aut Phenolic metabolites of anthocyanins modulate mechanisms of endothelial function 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Anthocyanins are reported to have vascular bioactivity, however their mechanisms of action are largely unknown. Evidence suggests that anthocyanins modulate endothelial function, potentially by increasing nitric oxide (NO) synthesis, or enhancing NO bioavailability. This study compared the activity of cyanidin-3-glucoside, its degradation product protocatechuic acid, and phase II metabolite, vanillic acid. Production of NO and superoxide and expression of endothelial NO synthase (eNOS), NADPH oxidase (NOX), and heme oxygenase-1 (HO-1) were established in human vascular cell models. Nitric oxide levels were not modulated by the treatments, although eNOS was upregulated by cyanidin-3-glucoside, and superoxide production was decreased by both phenolic acids. Vanillic acid upregulated p22(phox) mRNA but did not alter NOX protein expression, although trends were observed for p47(phox) downregulation and HO-1 upregulation. Anthocyanin metabolites may therefore modulate vascular reactivity by inducing HO-1 and modulating NOX activity, resulting in reduced superoxide production and improved NO bioavailability. Anthocyanins - metabolism Human Umbilical Vein Endothelial Cells - metabolism Nitric Oxide Synthase Type III - metabolism Superoxides - metabolism Nitric Oxide - metabolism Phenols - metabolism Czank, Charles oth Woodward, Gary M oth Cassidy, Aedín oth Kay, Colin D oth Enthalten in Journal of agricultural and food chemistry Columbus, Ohio : American Chemical Soc., 1953 63(2015), 9, Seite 2423 (DE-627)129602795 (DE-600)241619-0 (DE-576)015096610 0021-8561 nnns volume:63 year:2015 number:9 pages:2423 http://www.ncbi.nlm.nih.gov/pubmed/25686009 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_70 GBV_ILN_2006 GBV_ILN_4219 58.27 AVZ 58.34 AVZ 42.63 AVZ AR 63 2015 9 2423 |
| allfields_unstemmed |
PQ20160617 (DE-627)OLC1963006895 (DE-599)GBVOLC1963006895 (PRQ)p838-e237ad9418a80dbf7f599890832600e08ce9fcf20d06323f772208f5403df34f0 (KEY)0011841920150000063000902423phenolicmetabolitesofanthocyaninsmodulatemechanism DE-627 ger DE-627 rakwb eng 630 640 540 DNB 58.27 bkl 58.34 bkl 42.63 bkl Edwards, Michael verfasserin aut Phenolic metabolites of anthocyanins modulate mechanisms of endothelial function 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Anthocyanins are reported to have vascular bioactivity, however their mechanisms of action are largely unknown. Evidence suggests that anthocyanins modulate endothelial function, potentially by increasing nitric oxide (NO) synthesis, or enhancing NO bioavailability. This study compared the activity of cyanidin-3-glucoside, its degradation product protocatechuic acid, and phase II metabolite, vanillic acid. Production of NO and superoxide and expression of endothelial NO synthase (eNOS), NADPH oxidase (NOX), and heme oxygenase-1 (HO-1) were established in human vascular cell models. Nitric oxide levels were not modulated by the treatments, although eNOS was upregulated by cyanidin-3-glucoside, and superoxide production was decreased by both phenolic acids. Vanillic acid upregulated p22(phox) mRNA but did not alter NOX protein expression, although trends were observed for p47(phox) downregulation and HO-1 upregulation. Anthocyanin metabolites may therefore modulate vascular reactivity by inducing HO-1 and modulating NOX activity, resulting in reduced superoxide production and improved NO bioavailability. Anthocyanins - metabolism Human Umbilical Vein Endothelial Cells - metabolism Nitric Oxide Synthase Type III - metabolism Superoxides - metabolism Nitric Oxide - metabolism Phenols - metabolism Czank, Charles oth Woodward, Gary M oth Cassidy, Aedín oth Kay, Colin D oth Enthalten in Journal of agricultural and food chemistry Columbus, Ohio : American Chemical Soc., 1953 63(2015), 9, Seite 2423 (DE-627)129602795 (DE-600)241619-0 (DE-576)015096610 0021-8561 nnns volume:63 year:2015 number:9 pages:2423 http://www.ncbi.nlm.nih.gov/pubmed/25686009 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_70 GBV_ILN_2006 GBV_ILN_4219 58.27 AVZ 58.34 AVZ 42.63 AVZ AR 63 2015 9 2423 |
| allfieldsGer |
PQ20160617 (DE-627)OLC1963006895 (DE-599)GBVOLC1963006895 (PRQ)p838-e237ad9418a80dbf7f599890832600e08ce9fcf20d06323f772208f5403df34f0 (KEY)0011841920150000063000902423phenolicmetabolitesofanthocyaninsmodulatemechanism DE-627 ger DE-627 rakwb eng 630 640 540 DNB 58.27 bkl 58.34 bkl 42.63 bkl Edwards, Michael verfasserin aut Phenolic metabolites of anthocyanins modulate mechanisms of endothelial function 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Anthocyanins are reported to have vascular bioactivity, however their mechanisms of action are largely unknown. Evidence suggests that anthocyanins modulate endothelial function, potentially by increasing nitric oxide (NO) synthesis, or enhancing NO bioavailability. This study compared the activity of cyanidin-3-glucoside, its degradation product protocatechuic acid, and phase II metabolite, vanillic acid. Production of NO and superoxide and expression of endothelial NO synthase (eNOS), NADPH oxidase (NOX), and heme oxygenase-1 (HO-1) were established in human vascular cell models. Nitric oxide levels were not modulated by the treatments, although eNOS was upregulated by cyanidin-3-glucoside, and superoxide production was decreased by both phenolic acids. Vanillic acid upregulated p22(phox) mRNA but did not alter NOX protein expression, although trends were observed for p47(phox) downregulation and HO-1 upregulation. Anthocyanin metabolites may therefore modulate vascular reactivity by inducing HO-1 and modulating NOX activity, resulting in reduced superoxide production and improved NO bioavailability. Anthocyanins - metabolism Human Umbilical Vein Endothelial Cells - metabolism Nitric Oxide Synthase Type III - metabolism Superoxides - metabolism Nitric Oxide - metabolism Phenols - metabolism Czank, Charles oth Woodward, Gary M oth Cassidy, Aedín oth Kay, Colin D oth Enthalten in Journal of agricultural and food chemistry Columbus, Ohio : American Chemical Soc., 1953 63(2015), 9, Seite 2423 (DE-627)129602795 (DE-600)241619-0 (DE-576)015096610 0021-8561 nnns volume:63 year:2015 number:9 pages:2423 http://www.ncbi.nlm.nih.gov/pubmed/25686009 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_70 GBV_ILN_2006 GBV_ILN_4219 58.27 AVZ 58.34 AVZ 42.63 AVZ AR 63 2015 9 2423 |
| allfieldsSound |
PQ20160617 (DE-627)OLC1963006895 (DE-599)GBVOLC1963006895 (PRQ)p838-e237ad9418a80dbf7f599890832600e08ce9fcf20d06323f772208f5403df34f0 (KEY)0011841920150000063000902423phenolicmetabolitesofanthocyaninsmodulatemechanism DE-627 ger DE-627 rakwb eng 630 640 540 DNB 58.27 bkl 58.34 bkl 42.63 bkl Edwards, Michael verfasserin aut Phenolic metabolites of anthocyanins modulate mechanisms of endothelial function 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Anthocyanins are reported to have vascular bioactivity, however their mechanisms of action are largely unknown. Evidence suggests that anthocyanins modulate endothelial function, potentially by increasing nitric oxide (NO) synthesis, or enhancing NO bioavailability. This study compared the activity of cyanidin-3-glucoside, its degradation product protocatechuic acid, and phase II metabolite, vanillic acid. Production of NO and superoxide and expression of endothelial NO synthase (eNOS), NADPH oxidase (NOX), and heme oxygenase-1 (HO-1) were established in human vascular cell models. Nitric oxide levels were not modulated by the treatments, although eNOS was upregulated by cyanidin-3-glucoside, and superoxide production was decreased by both phenolic acids. Vanillic acid upregulated p22(phox) mRNA but did not alter NOX protein expression, although trends were observed for p47(phox) downregulation and HO-1 upregulation. Anthocyanin metabolites may therefore modulate vascular reactivity by inducing HO-1 and modulating NOX activity, resulting in reduced superoxide production and improved NO bioavailability. Anthocyanins - metabolism Human Umbilical Vein Endothelial Cells - metabolism Nitric Oxide Synthase Type III - metabolism Superoxides - metabolism Nitric Oxide - metabolism Phenols - metabolism Czank, Charles oth Woodward, Gary M oth Cassidy, Aedín oth Kay, Colin D oth Enthalten in Journal of agricultural and food chemistry Columbus, Ohio : American Chemical Soc., 1953 63(2015), 9, Seite 2423 (DE-627)129602795 (DE-600)241619-0 (DE-576)015096610 0021-8561 nnns volume:63 year:2015 number:9 pages:2423 http://www.ncbi.nlm.nih.gov/pubmed/25686009 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_70 GBV_ILN_2006 GBV_ILN_4219 58.27 AVZ 58.34 AVZ 42.63 AVZ AR 63 2015 9 2423 |
| language |
English |
| source |
Enthalten in Journal of agricultural and food chemistry 63(2015), 9, Seite 2423 volume:63 year:2015 number:9 pages:2423 |
| sourceStr |
Enthalten in Journal of agricultural and food chemistry 63(2015), 9, Seite 2423 volume:63 year:2015 number:9 pages:2423 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| topic_facet |
Anthocyanins - metabolism Human Umbilical Vein Endothelial Cells - metabolism Nitric Oxide Synthase Type III - metabolism Superoxides - metabolism Nitric Oxide - metabolism Phenols - metabolism |
| dewey-raw |
630 |
| isfreeaccess_bool |
false |
| container_title |
Journal of agricultural and food chemistry |
| authorswithroles_txt_mv |
Edwards, Michael @@aut@@ Czank, Charles @@oth@@ Woodward, Gary M @@oth@@ Cassidy, Aedín @@oth@@ Kay, Colin D @@oth@@ |
| publishDateDaySort_date |
2015-01-01T00:00:00Z |
| hierarchy_top_id |
129602795 |
| dewey-sort |
3630 |
| id |
OLC1963006895 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a2200265 4500</leader><controlfield tag="001">OLC1963006895</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230513021844.0</controlfield><controlfield tag="007">tu</controlfield><controlfield tag="008">160206s2015 xx ||||| 00| ||eng c</controlfield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">PQ20160617</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)OLC1963006895</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBVOLC1963006895</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(PRQ)p838-e237ad9418a80dbf7f599890832600e08ce9fcf20d06323f772208f5403df34f0</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(KEY)0011841920150000063000902423phenolicmetabolitesofanthocyaninsmodulatemechanism</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">630</subfield><subfield code="a">640</subfield><subfield code="a">540</subfield><subfield code="q">DNB</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">58.27</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">58.34</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">42.63</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Edwards, Michael</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Phenolic metabolites of anthocyanins modulate mechanisms of endothelial function</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2015</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">ohne Hilfsmittel zu benutzen</subfield><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Band</subfield><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Anthocyanins are reported to have vascular bioactivity, however their mechanisms of action are largely unknown. Evidence suggests that anthocyanins modulate endothelial function, potentially by increasing nitric oxide (NO) synthesis, or enhancing NO bioavailability. This study compared the activity of cyanidin-3-glucoside, its degradation product protocatechuic acid, and phase II metabolite, vanillic acid. Production of NO and superoxide and expression of endothelial NO synthase (eNOS), NADPH oxidase (NOX), and heme oxygenase-1 (HO-1) were established in human vascular cell models. Nitric oxide levels were not modulated by the treatments, although eNOS was upregulated by cyanidin-3-glucoside, and superoxide production was decreased by both phenolic acids. Vanillic acid upregulated p22(phox) mRNA but did not alter NOX protein expression, although trends were observed for p47(phox) downregulation and HO-1 upregulation. Anthocyanin metabolites may therefore modulate vascular reactivity by inducing HO-1 and modulating NOX activity, resulting in reduced superoxide production and improved NO bioavailability.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Anthocyanins - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Human Umbilical Vein Endothelial Cells - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Nitric Oxide Synthase Type III - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Superoxides - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Nitric Oxide - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Phenols - metabolism</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Czank, Charles</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Woodward, Gary M</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cassidy, Aedín</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kay, Colin D</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Journal of agricultural and food chemistry</subfield><subfield code="d">Columbus, Ohio : American Chemical Soc., 1953</subfield><subfield code="g">63(2015), 9, Seite 2423</subfield><subfield code="w">(DE-627)129602795</subfield><subfield code="w">(DE-600)241619-0</subfield><subfield code="w">(DE-576)015096610</subfield><subfield code="x">0021-8561</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:63</subfield><subfield code="g">year:2015</subfield><subfield code="g">number:9</subfield><subfield code="g">pages:2423</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">http://www.ncbi.nlm.nih.gov/pubmed/25686009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_OLC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-TEC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-CHE</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-DE-84</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OPC-FOR</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2006</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4219</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">58.27</subfield><subfield code="q">AVZ</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">58.34</subfield><subfield code="q">AVZ</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">42.63</subfield><subfield code="q">AVZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">63</subfield><subfield code="j">2015</subfield><subfield code="e">9</subfield><subfield code="h">2423</subfield></datafield></record></collection>
|
| author |
Edwards, Michael |
| spellingShingle |
Edwards, Michael ddc 630 bkl 58.27 bkl 58.34 bkl 42.63 misc Anthocyanins - metabolism misc Human Umbilical Vein Endothelial Cells - metabolism misc Nitric Oxide Synthase Type III - metabolism misc Superoxides - metabolism misc Nitric Oxide - metabolism misc Phenols - metabolism Phenolic metabolites of anthocyanins modulate mechanisms of endothelial function |
| authorStr |
Edwards, Michael |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)129602795 |
| format |
Article |
| dewey-ones |
630 - Agriculture & related technologies 640 - Home & family management 540 - Chemistry & allied sciences |
| delete_txt_mv |
keep |
| author_role |
aut |
| collection |
OLC |
| remote_str |
false |
| illustrated |
Not Illustrated |
| issn |
0021-8561 |
| topic_title |
630 640 540 DNB 58.27 bkl 58.34 bkl 42.63 bkl Phenolic metabolites of anthocyanins modulate mechanisms of endothelial function Anthocyanins - metabolism Human Umbilical Vein Endothelial Cells - metabolism Nitric Oxide Synthase Type III - metabolism Superoxides - metabolism Nitric Oxide - metabolism Phenols - metabolism |
| topic |
ddc 630 bkl 58.27 bkl 58.34 bkl 42.63 misc Anthocyanins - metabolism misc Human Umbilical Vein Endothelial Cells - metabolism misc Nitric Oxide Synthase Type III - metabolism misc Superoxides - metabolism misc Nitric Oxide - metabolism misc Phenols - metabolism |
| topic_unstemmed |
ddc 630 bkl 58.27 bkl 58.34 bkl 42.63 misc Anthocyanins - metabolism misc Human Umbilical Vein Endothelial Cells - metabolism misc Nitric Oxide Synthase Type III - metabolism misc Superoxides - metabolism misc Nitric Oxide - metabolism misc Phenols - metabolism |
| topic_browse |
ddc 630 bkl 58.27 bkl 58.34 bkl 42.63 misc Anthocyanins - metabolism misc Human Umbilical Vein Endothelial Cells - metabolism misc Nitric Oxide Synthase Type III - metabolism misc Superoxides - metabolism misc Nitric Oxide - metabolism misc Phenols - metabolism |
| format_facet |
Aufsätze Gedruckte Aufsätze |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
nc |
| author2_variant |
c c cc g m w gm gmw a c ac c d k cd cdk |
| hierarchy_parent_title |
Journal of agricultural and food chemistry |
| hierarchy_parent_id |
129602795 |
| dewey-tens |
630 - Agriculture 640 - Home & family management 540 - Chemistry |
| hierarchy_top_title |
Journal of agricultural and food chemistry |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)129602795 (DE-600)241619-0 (DE-576)015096610 |
| title |
Phenolic metabolites of anthocyanins modulate mechanisms of endothelial function |
| ctrlnum |
(DE-627)OLC1963006895 (DE-599)GBVOLC1963006895 (PRQ)p838-e237ad9418a80dbf7f599890832600e08ce9fcf20d06323f772208f5403df34f0 (KEY)0011841920150000063000902423phenolicmetabolitesofanthocyaninsmodulatemechanism |
| title_full |
Phenolic metabolites of anthocyanins modulate mechanisms of endothelial function |
| author_sort |
Edwards, Michael |
| journal |
Journal of agricultural and food chemistry |
| journalStr |
Journal of agricultural and food chemistry |
| lang_code |
eng |
| isOA_bool |
false |
| dewey-hundreds |
600 - Technology 500 - Science |
| recordtype |
marc |
| publishDateSort |
2015 |
| contenttype_str_mv |
txt |
| container_start_page |
2423 |
| author_browse |
Edwards, Michael |
| container_volume |
63 |
| class |
630 640 540 DNB 58.27 bkl 58.34 bkl 42.63 bkl |
| format_se |
Aufsätze |
| author-letter |
Edwards, Michael |
| dewey-full |
630 640 540 |
| title_sort |
phenolic metabolites of anthocyanins modulate mechanisms of endothelial function |
| title_auth |
Phenolic metabolites of anthocyanins modulate mechanisms of endothelial function |
| abstract |
Anthocyanins are reported to have vascular bioactivity, however their mechanisms of action are largely unknown. Evidence suggests that anthocyanins modulate endothelial function, potentially by increasing nitric oxide (NO) synthesis, or enhancing NO bioavailability. This study compared the activity of cyanidin-3-glucoside, its degradation product protocatechuic acid, and phase II metabolite, vanillic acid. Production of NO and superoxide and expression of endothelial NO synthase (eNOS), NADPH oxidase (NOX), and heme oxygenase-1 (HO-1) were established in human vascular cell models. Nitric oxide levels were not modulated by the treatments, although eNOS was upregulated by cyanidin-3-glucoside, and superoxide production was decreased by both phenolic acids. Vanillic acid upregulated p22(phox) mRNA but did not alter NOX protein expression, although trends were observed for p47(phox) downregulation and HO-1 upregulation. Anthocyanin metabolites may therefore modulate vascular reactivity by inducing HO-1 and modulating NOX activity, resulting in reduced superoxide production and improved NO bioavailability. |
| abstractGer |
Anthocyanins are reported to have vascular bioactivity, however their mechanisms of action are largely unknown. Evidence suggests that anthocyanins modulate endothelial function, potentially by increasing nitric oxide (NO) synthesis, or enhancing NO bioavailability. This study compared the activity of cyanidin-3-glucoside, its degradation product protocatechuic acid, and phase II metabolite, vanillic acid. Production of NO and superoxide and expression of endothelial NO synthase (eNOS), NADPH oxidase (NOX), and heme oxygenase-1 (HO-1) were established in human vascular cell models. Nitric oxide levels were not modulated by the treatments, although eNOS was upregulated by cyanidin-3-glucoside, and superoxide production was decreased by both phenolic acids. Vanillic acid upregulated p22(phox) mRNA but did not alter NOX protein expression, although trends were observed for p47(phox) downregulation and HO-1 upregulation. Anthocyanin metabolites may therefore modulate vascular reactivity by inducing HO-1 and modulating NOX activity, resulting in reduced superoxide production and improved NO bioavailability. |
| abstract_unstemmed |
Anthocyanins are reported to have vascular bioactivity, however their mechanisms of action are largely unknown. Evidence suggests that anthocyanins modulate endothelial function, potentially by increasing nitric oxide (NO) synthesis, or enhancing NO bioavailability. This study compared the activity of cyanidin-3-glucoside, its degradation product protocatechuic acid, and phase II metabolite, vanillic acid. Production of NO and superoxide and expression of endothelial NO synthase (eNOS), NADPH oxidase (NOX), and heme oxygenase-1 (HO-1) were established in human vascular cell models. Nitric oxide levels were not modulated by the treatments, although eNOS was upregulated by cyanidin-3-glucoside, and superoxide production was decreased by both phenolic acids. Vanillic acid upregulated p22(phox) mRNA but did not alter NOX protein expression, although trends were observed for p47(phox) downregulation and HO-1 upregulation. Anthocyanin metabolites may therefore modulate vascular reactivity by inducing HO-1 and modulating NOX activity, resulting in reduced superoxide production and improved NO bioavailability. |
| collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_70 GBV_ILN_2006 GBV_ILN_4219 |
| container_issue |
9 |
| title_short |
Phenolic metabolites of anthocyanins modulate mechanisms of endothelial function |
| url |
http://www.ncbi.nlm.nih.gov/pubmed/25686009 |
| remote_bool |
false |
| author2 |
Czank, Charles Woodward, Gary M Cassidy, Aedín Kay, Colin D |
| author2Str |
Czank, Charles Woodward, Gary M Cassidy, Aedín Kay, Colin D |
| ppnlink |
129602795 |
| mediatype_str_mv |
n |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth oth oth oth |
| up_date |
2024-07-04T04:45:13.393Z |
| _version_ |
1803622351785426944 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a2200265 4500</leader><controlfield tag="001">OLC1963006895</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230513021844.0</controlfield><controlfield tag="007">tu</controlfield><controlfield tag="008">160206s2015 xx ||||| 00| ||eng c</controlfield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">PQ20160617</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)OLC1963006895</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBVOLC1963006895</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(PRQ)p838-e237ad9418a80dbf7f599890832600e08ce9fcf20d06323f772208f5403df34f0</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(KEY)0011841920150000063000902423phenolicmetabolitesofanthocyaninsmodulatemechanism</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">630</subfield><subfield code="a">640</subfield><subfield code="a">540</subfield><subfield code="q">DNB</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">58.27</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">58.34</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">42.63</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Edwards, Michael</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Phenolic metabolites of anthocyanins modulate mechanisms of endothelial function</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2015</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">ohne Hilfsmittel zu benutzen</subfield><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Band</subfield><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Anthocyanins are reported to have vascular bioactivity, however their mechanisms of action are largely unknown. Evidence suggests that anthocyanins modulate endothelial function, potentially by increasing nitric oxide (NO) synthesis, or enhancing NO bioavailability. This study compared the activity of cyanidin-3-glucoside, its degradation product protocatechuic acid, and phase II metabolite, vanillic acid. Production of NO and superoxide and expression of endothelial NO synthase (eNOS), NADPH oxidase (NOX), and heme oxygenase-1 (HO-1) were established in human vascular cell models. Nitric oxide levels were not modulated by the treatments, although eNOS was upregulated by cyanidin-3-glucoside, and superoxide production was decreased by both phenolic acids. Vanillic acid upregulated p22(phox) mRNA but did not alter NOX protein expression, although trends were observed for p47(phox) downregulation and HO-1 upregulation. Anthocyanin metabolites may therefore modulate vascular reactivity by inducing HO-1 and modulating NOX activity, resulting in reduced superoxide production and improved NO bioavailability.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Anthocyanins - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Human Umbilical Vein Endothelial Cells - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Nitric Oxide Synthase Type III - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Superoxides - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Nitric Oxide - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Phenols - metabolism</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Czank, Charles</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Woodward, Gary M</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cassidy, Aedín</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kay, Colin D</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Journal of agricultural and food chemistry</subfield><subfield code="d">Columbus, Ohio : American Chemical Soc., 1953</subfield><subfield code="g">63(2015), 9, Seite 2423</subfield><subfield code="w">(DE-627)129602795</subfield><subfield code="w">(DE-600)241619-0</subfield><subfield code="w">(DE-576)015096610</subfield><subfield code="x">0021-8561</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:63</subfield><subfield code="g">year:2015</subfield><subfield code="g">number:9</subfield><subfield code="g">pages:2423</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">http://www.ncbi.nlm.nih.gov/pubmed/25686009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_OLC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-TEC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-CHE</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-DE-84</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OPC-FOR</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2006</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4219</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">58.27</subfield><subfield code="q">AVZ</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">58.34</subfield><subfield code="q">AVZ</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">42.63</subfield><subfield code="q">AVZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">63</subfield><subfield code="j">2015</subfield><subfield code="e">9</subfield><subfield code="h">2423</subfield></datafield></record></collection>
|
| score |
7.399373 |