Sesamol Enhances Cell Growth and the Biosynthesis and Accumulation of Docosahexaenoic Acid in the Microalga Crypthecodinium cohnii
Sesamol is a strong antioxidant phenolic compound found in sesame seed. It possesses the ability to scavenge intracellular reactive oxygen species (ROS) and to inhibit malic enzyme activity and NADPH supply, resulting possibly in cell proliferation and alteration in the fatty acid composition. In th...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Liu, Bin [verfasserIn] |
|---|
| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
Dinoflagellida - growth & development Docosahexaenoic Acids - biosynthesis Reactive Oxygen Species - metabolism |
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| Übergeordnetes Werk: |
Enthalten in: Journal of agricultural and food chemistry - Columbus, Ohio : American Chemical Soc., 1953, 63(2015), 23, Seite 5640 |
|---|---|
| Übergeordnetes Werk: |
volume:63 ; year:2015 ; number:23 ; pages:5640 |
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| 520 | |a Sesamol is a strong antioxidant phenolic compound found in sesame seed. It possesses the ability to scavenge intracellular reactive oxygen species (ROS) and to inhibit malic enzyme activity and NADPH supply, resulting possibly in cell proliferation and alteration in the fatty acid composition. In the present study, the effect of sesamol on the growth and accumulation of docosahexaenoic acid (DHA) was investigated in the marine microalga Crypthecodinium cohnii, a prolific producer of DHA. C. cohnii showed a great decrease in the intracellular ROS level with the addition of sesamol. In contrast, the biomass concentration, DHA content (% of total fatty acids), and DHA productivity were significantly increased by 44.20, 11.25, and 20.00%, respectively (P < 0.01). Taken together, this work represents the first report of employing sesamol for enhanced production of DHA by C. cohnii, providing valuable insights into this alga for future biotechnological applications. | ||
| 650 | 4 | |a Benzodioxoles - pharmacology | |
| 650 | 4 | |a Dinoflagellida - growth & development | |
| 650 | 4 | |a Microalgae - metabolism | |
| 650 | 4 | |a Docosahexaenoic Acids - biosynthesis | |
| 650 | 4 | |a Dinoflagellida - metabolism | |
| 650 | 4 | |a Microalgae - drug effects | |
| 650 | 4 | |a Reactive Oxygen Species - metabolism | |
| 650 | 4 | |a Phenols - pharmacology | |
| 650 | 4 | |a Microalgae - growth & development | |
| 650 | 4 | |a Dinoflagellida - drug effects | |
| 700 | 1 | |a Liu, Jin |4 oth | |
| 700 | 1 | |a Sun, Peipei |4 oth | |
| 700 | 1 | |a Ma, Xiaonian |4 oth | |
| 700 | 1 | |a Jiang, Yue |4 oth | |
| 700 | 1 | |a Chen, Feng |4 oth | |
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PQ20160617 (DE-627)OLC1963013085 (DE-599)GBVOLC1963013085 (PRQ)p839-dbbd7f65da097c816ab10ee28af12658c9e52046d3035a20942f9441cc0536c30 (KEY)0011841920150000063002305640sesamolenhancescellgrowthandthebiosynthesisandaccu DE-627 ger DE-627 rakwb eng 630 640 540 DNB 58.27 bkl 58.34 bkl 42.63 bkl Liu, Bin verfasserin aut Sesamol Enhances Cell Growth and the Biosynthesis and Accumulation of Docosahexaenoic Acid in the Microalga Crypthecodinium cohnii 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Sesamol is a strong antioxidant phenolic compound found in sesame seed. It possesses the ability to scavenge intracellular reactive oxygen species (ROS) and to inhibit malic enzyme activity and NADPH supply, resulting possibly in cell proliferation and alteration in the fatty acid composition. In the present study, the effect of sesamol on the growth and accumulation of docosahexaenoic acid (DHA) was investigated in the marine microalga Crypthecodinium cohnii, a prolific producer of DHA. C. cohnii showed a great decrease in the intracellular ROS level with the addition of sesamol. In contrast, the biomass concentration, DHA content (% of total fatty acids), and DHA productivity were significantly increased by 44.20, 11.25, and 20.00%, respectively (P < 0.01). Taken together, this work represents the first report of employing sesamol for enhanced production of DHA by C. cohnii, providing valuable insights into this alga for future biotechnological applications. Benzodioxoles - pharmacology Dinoflagellida - growth & development Microalgae - metabolism Docosahexaenoic Acids - biosynthesis Dinoflagellida - metabolism Microalgae - drug effects Reactive Oxygen Species - metabolism Phenols - pharmacology Microalgae - growth & development Dinoflagellida - drug effects Liu, Jin oth Sun, Peipei oth Ma, Xiaonian oth Jiang, Yue oth Chen, Feng oth Enthalten in Journal of agricultural and food chemistry Columbus, Ohio : American Chemical Soc., 1953 63(2015), 23, Seite 5640 (DE-627)129602795 (DE-600)241619-0 (DE-576)015096610 0021-8561 nnns volume:63 year:2015 number:23 pages:5640 http://www.ncbi.nlm.nih.gov/pubmed/26017014 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_70 GBV_ILN_2006 GBV_ILN_4219 58.27 AVZ 58.34 AVZ 42.63 AVZ AR 63 2015 23 5640 |
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PQ20160617 (DE-627)OLC1963013085 (DE-599)GBVOLC1963013085 (PRQ)p839-dbbd7f65da097c816ab10ee28af12658c9e52046d3035a20942f9441cc0536c30 (KEY)0011841920150000063002305640sesamolenhancescellgrowthandthebiosynthesisandaccu DE-627 ger DE-627 rakwb eng 630 640 540 DNB 58.27 bkl 58.34 bkl 42.63 bkl Liu, Bin verfasserin aut Sesamol Enhances Cell Growth and the Biosynthesis and Accumulation of Docosahexaenoic Acid in the Microalga Crypthecodinium cohnii 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Sesamol is a strong antioxidant phenolic compound found in sesame seed. It possesses the ability to scavenge intracellular reactive oxygen species (ROS) and to inhibit malic enzyme activity and NADPH supply, resulting possibly in cell proliferation and alteration in the fatty acid composition. In the present study, the effect of sesamol on the growth and accumulation of docosahexaenoic acid (DHA) was investigated in the marine microalga Crypthecodinium cohnii, a prolific producer of DHA. C. cohnii showed a great decrease in the intracellular ROS level with the addition of sesamol. In contrast, the biomass concentration, DHA content (% of total fatty acids), and DHA productivity were significantly increased by 44.20, 11.25, and 20.00%, respectively (P < 0.01). Taken together, this work represents the first report of employing sesamol for enhanced production of DHA by C. cohnii, providing valuable insights into this alga for future biotechnological applications. Benzodioxoles - pharmacology Dinoflagellida - growth & development Microalgae - metabolism Docosahexaenoic Acids - biosynthesis Dinoflagellida - metabolism Microalgae - drug effects Reactive Oxygen Species - metabolism Phenols - pharmacology Microalgae - growth & development Dinoflagellida - drug effects Liu, Jin oth Sun, Peipei oth Ma, Xiaonian oth Jiang, Yue oth Chen, Feng oth Enthalten in Journal of agricultural and food chemistry Columbus, Ohio : American Chemical Soc., 1953 63(2015), 23, Seite 5640 (DE-627)129602795 (DE-600)241619-0 (DE-576)015096610 0021-8561 nnns volume:63 year:2015 number:23 pages:5640 http://www.ncbi.nlm.nih.gov/pubmed/26017014 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_70 GBV_ILN_2006 GBV_ILN_4219 58.27 AVZ 58.34 AVZ 42.63 AVZ AR 63 2015 23 5640 |
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PQ20160617 (DE-627)OLC1963013085 (DE-599)GBVOLC1963013085 (PRQ)p839-dbbd7f65da097c816ab10ee28af12658c9e52046d3035a20942f9441cc0536c30 (KEY)0011841920150000063002305640sesamolenhancescellgrowthandthebiosynthesisandaccu DE-627 ger DE-627 rakwb eng 630 640 540 DNB 58.27 bkl 58.34 bkl 42.63 bkl Liu, Bin verfasserin aut Sesamol Enhances Cell Growth and the Biosynthesis and Accumulation of Docosahexaenoic Acid in the Microalga Crypthecodinium cohnii 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Sesamol is a strong antioxidant phenolic compound found in sesame seed. It possesses the ability to scavenge intracellular reactive oxygen species (ROS) and to inhibit malic enzyme activity and NADPH supply, resulting possibly in cell proliferation and alteration in the fatty acid composition. In the present study, the effect of sesamol on the growth and accumulation of docosahexaenoic acid (DHA) was investigated in the marine microalga Crypthecodinium cohnii, a prolific producer of DHA. C. cohnii showed a great decrease in the intracellular ROS level with the addition of sesamol. In contrast, the biomass concentration, DHA content (% of total fatty acids), and DHA productivity were significantly increased by 44.20, 11.25, and 20.00%, respectively (P < 0.01). Taken together, this work represents the first report of employing sesamol for enhanced production of DHA by C. cohnii, providing valuable insights into this alga for future biotechnological applications. Benzodioxoles - pharmacology Dinoflagellida - growth & development Microalgae - metabolism Docosahexaenoic Acids - biosynthesis Dinoflagellida - metabolism Microalgae - drug effects Reactive Oxygen Species - metabolism Phenols - pharmacology Microalgae - growth & development Dinoflagellida - drug effects Liu, Jin oth Sun, Peipei oth Ma, Xiaonian oth Jiang, Yue oth Chen, Feng oth Enthalten in Journal of agricultural and food chemistry Columbus, Ohio : American Chemical Soc., 1953 63(2015), 23, Seite 5640 (DE-627)129602795 (DE-600)241619-0 (DE-576)015096610 0021-8561 nnns volume:63 year:2015 number:23 pages:5640 http://www.ncbi.nlm.nih.gov/pubmed/26017014 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_70 GBV_ILN_2006 GBV_ILN_4219 58.27 AVZ 58.34 AVZ 42.63 AVZ AR 63 2015 23 5640 |
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PQ20160617 (DE-627)OLC1963013085 (DE-599)GBVOLC1963013085 (PRQ)p839-dbbd7f65da097c816ab10ee28af12658c9e52046d3035a20942f9441cc0536c30 (KEY)0011841920150000063002305640sesamolenhancescellgrowthandthebiosynthesisandaccu DE-627 ger DE-627 rakwb eng 630 640 540 DNB 58.27 bkl 58.34 bkl 42.63 bkl Liu, Bin verfasserin aut Sesamol Enhances Cell Growth and the Biosynthesis and Accumulation of Docosahexaenoic Acid in the Microalga Crypthecodinium cohnii 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Sesamol is a strong antioxidant phenolic compound found in sesame seed. It possesses the ability to scavenge intracellular reactive oxygen species (ROS) and to inhibit malic enzyme activity and NADPH supply, resulting possibly in cell proliferation and alteration in the fatty acid composition. In the present study, the effect of sesamol on the growth and accumulation of docosahexaenoic acid (DHA) was investigated in the marine microalga Crypthecodinium cohnii, a prolific producer of DHA. C. cohnii showed a great decrease in the intracellular ROS level with the addition of sesamol. In contrast, the biomass concentration, DHA content (% of total fatty acids), and DHA productivity were significantly increased by 44.20, 11.25, and 20.00%, respectively (P < 0.01). Taken together, this work represents the first report of employing sesamol for enhanced production of DHA by C. cohnii, providing valuable insights into this alga for future biotechnological applications. Benzodioxoles - pharmacology Dinoflagellida - growth & development Microalgae - metabolism Docosahexaenoic Acids - biosynthesis Dinoflagellida - metabolism Microalgae - drug effects Reactive Oxygen Species - metabolism Phenols - pharmacology Microalgae - growth & development Dinoflagellida - drug effects Liu, Jin oth Sun, Peipei oth Ma, Xiaonian oth Jiang, Yue oth Chen, Feng oth Enthalten in Journal of agricultural and food chemistry Columbus, Ohio : American Chemical Soc., 1953 63(2015), 23, Seite 5640 (DE-627)129602795 (DE-600)241619-0 (DE-576)015096610 0021-8561 nnns volume:63 year:2015 number:23 pages:5640 http://www.ncbi.nlm.nih.gov/pubmed/26017014 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_70 GBV_ILN_2006 GBV_ILN_4219 58.27 AVZ 58.34 AVZ 42.63 AVZ AR 63 2015 23 5640 |
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PQ20160617 (DE-627)OLC1963013085 (DE-599)GBVOLC1963013085 (PRQ)p839-dbbd7f65da097c816ab10ee28af12658c9e52046d3035a20942f9441cc0536c30 (KEY)0011841920150000063002305640sesamolenhancescellgrowthandthebiosynthesisandaccu DE-627 ger DE-627 rakwb eng 630 640 540 DNB 58.27 bkl 58.34 bkl 42.63 bkl Liu, Bin verfasserin aut Sesamol Enhances Cell Growth and the Biosynthesis and Accumulation of Docosahexaenoic Acid in the Microalga Crypthecodinium cohnii 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Sesamol is a strong antioxidant phenolic compound found in sesame seed. It possesses the ability to scavenge intracellular reactive oxygen species (ROS) and to inhibit malic enzyme activity and NADPH supply, resulting possibly in cell proliferation and alteration in the fatty acid composition. In the present study, the effect of sesamol on the growth and accumulation of docosahexaenoic acid (DHA) was investigated in the marine microalga Crypthecodinium cohnii, a prolific producer of DHA. C. cohnii showed a great decrease in the intracellular ROS level with the addition of sesamol. In contrast, the biomass concentration, DHA content (% of total fatty acids), and DHA productivity were significantly increased by 44.20, 11.25, and 20.00%, respectively (P < 0.01). Taken together, this work represents the first report of employing sesamol for enhanced production of DHA by C. cohnii, providing valuable insights into this alga for future biotechnological applications. Benzodioxoles - pharmacology Dinoflagellida - growth & development Microalgae - metabolism Docosahexaenoic Acids - biosynthesis Dinoflagellida - metabolism Microalgae - drug effects Reactive Oxygen Species - metabolism Phenols - pharmacology Microalgae - growth & development Dinoflagellida - drug effects Liu, Jin oth Sun, Peipei oth Ma, Xiaonian oth Jiang, Yue oth Chen, Feng oth Enthalten in Journal of agricultural and food chemistry Columbus, Ohio : American Chemical Soc., 1953 63(2015), 23, Seite 5640 (DE-627)129602795 (DE-600)241619-0 (DE-576)015096610 0021-8561 nnns volume:63 year:2015 number:23 pages:5640 http://www.ncbi.nlm.nih.gov/pubmed/26017014 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_70 GBV_ILN_2006 GBV_ILN_4219 58.27 AVZ 58.34 AVZ 42.63 AVZ AR 63 2015 23 5640 |
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Liu, Bin ddc 630 bkl 58.27 bkl 58.34 bkl 42.63 misc Benzodioxoles - pharmacology misc Dinoflagellida - growth & development misc Microalgae - metabolism misc Docosahexaenoic Acids - biosynthesis misc Dinoflagellida - metabolism misc Microalgae - drug effects misc Reactive Oxygen Species - metabolism misc Phenols - pharmacology misc Microalgae - growth & development misc Dinoflagellida - drug effects Sesamol Enhances Cell Growth and the Biosynthesis and Accumulation of Docosahexaenoic Acid in the Microalga Crypthecodinium cohnii |
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630 640 540 DNB 58.27 bkl 58.34 bkl 42.63 bkl Sesamol Enhances Cell Growth and the Biosynthesis and Accumulation of Docosahexaenoic Acid in the Microalga Crypthecodinium cohnii Benzodioxoles - pharmacology Dinoflagellida - growth & development Microalgae - metabolism Docosahexaenoic Acids - biosynthesis Dinoflagellida - metabolism Microalgae - drug effects Reactive Oxygen Species - metabolism Phenols - pharmacology Microalgae - growth & development Dinoflagellida - drug effects |
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Sesamol Enhances Cell Growth and the Biosynthesis and Accumulation of Docosahexaenoic Acid in the Microalga Crypthecodinium cohnii |
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Sesamol Enhances Cell Growth and the Biosynthesis and Accumulation of Docosahexaenoic Acid in the Microalga Crypthecodinium cohnii |
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sesamol enhances cell growth and the biosynthesis and accumulation of docosahexaenoic acid in the microalga crypthecodinium cohnii |
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Sesamol Enhances Cell Growth and the Biosynthesis and Accumulation of Docosahexaenoic Acid in the Microalga Crypthecodinium cohnii |
| abstract |
Sesamol is a strong antioxidant phenolic compound found in sesame seed. It possesses the ability to scavenge intracellular reactive oxygen species (ROS) and to inhibit malic enzyme activity and NADPH supply, resulting possibly in cell proliferation and alteration in the fatty acid composition. In the present study, the effect of sesamol on the growth and accumulation of docosahexaenoic acid (DHA) was investigated in the marine microalga Crypthecodinium cohnii, a prolific producer of DHA. C. cohnii showed a great decrease in the intracellular ROS level with the addition of sesamol. In contrast, the biomass concentration, DHA content (% of total fatty acids), and DHA productivity were significantly increased by 44.20, 11.25, and 20.00%, respectively (P < 0.01). Taken together, this work represents the first report of employing sesamol for enhanced production of DHA by C. cohnii, providing valuable insights into this alga for future biotechnological applications. |
| abstractGer |
Sesamol is a strong antioxidant phenolic compound found in sesame seed. It possesses the ability to scavenge intracellular reactive oxygen species (ROS) and to inhibit malic enzyme activity and NADPH supply, resulting possibly in cell proliferation and alteration in the fatty acid composition. In the present study, the effect of sesamol on the growth and accumulation of docosahexaenoic acid (DHA) was investigated in the marine microalga Crypthecodinium cohnii, a prolific producer of DHA. C. cohnii showed a great decrease in the intracellular ROS level with the addition of sesamol. In contrast, the biomass concentration, DHA content (% of total fatty acids), and DHA productivity were significantly increased by 44.20, 11.25, and 20.00%, respectively (P < 0.01). Taken together, this work represents the first report of employing sesamol for enhanced production of DHA by C. cohnii, providing valuable insights into this alga for future biotechnological applications. |
| abstract_unstemmed |
Sesamol is a strong antioxidant phenolic compound found in sesame seed. It possesses the ability to scavenge intracellular reactive oxygen species (ROS) and to inhibit malic enzyme activity and NADPH supply, resulting possibly in cell proliferation and alteration in the fatty acid composition. In the present study, the effect of sesamol on the growth and accumulation of docosahexaenoic acid (DHA) was investigated in the marine microalga Crypthecodinium cohnii, a prolific producer of DHA. C. cohnii showed a great decrease in the intracellular ROS level with the addition of sesamol. In contrast, the biomass concentration, DHA content (% of total fatty acids), and DHA productivity were significantly increased by 44.20, 11.25, and 20.00%, respectively (P < 0.01). Taken together, this work represents the first report of employing sesamol for enhanced production of DHA by C. cohnii, providing valuable insights into this alga for future biotechnological applications. |
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Sesamol Enhances Cell Growth and the Biosynthesis and Accumulation of Docosahexaenoic Acid in the Microalga Crypthecodinium cohnii |
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