Effects of fluoxetine on behavior, antioxidant enzyme systems, and multixenobiotic resistance in the Asian clam Corbicula fluminea
Fluoxetine (FLX), a selective serotonin reuptake inhibitor, is widespread in aquatic environments. Despite its reported effects on behavior and reproduction in aquatic species, little is known about the effects of FLX on cellular detoxification and defense system in bivalves. Here, the adult Asian c...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Chen, Huihui [verfasserIn] |
|---|
| Format: |
Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2015 |
|---|
| Rechteinformationen: |
Nutzungsrecht: Copyright © 2014 Elsevier Ltd. All rights reserved. |
|---|
| Systematik: |
|
|---|
| Übergeordnetes Werk: |
Enthalten in: Chemosphere - Kidlington, Oxford : Elsevier Science, 1972, 119(2015), Seite 856-862 |
|---|---|
| Übergeordnetes Werk: |
volume:119 ; year:2015 ; pages:856-862 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.chemosphere.2014.08.062 |
|---|
| Katalog-ID: |
OLC1963057724 |
|---|
| LEADER | 01000caa a2200265 4500 | ||
|---|---|---|---|
| 001 | OLC1963057724 | ||
| 003 | DE-627 | ||
| 005 | 20230508074903.0 | ||
| 007 | tu | ||
| 008 | 160206s2015 xx ||||| 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.chemosphere.2014.08.062 |2 doi | |
| 028 | 5 | 2 | |a PQ20160617 |
| 035 | |a (DE-627)OLC1963057724 | ||
| 035 | |a (DE-599)GBVOLC1963057724 | ||
| 035 | |a (PRQ)c1916-a350b9b5f853f8c0ffb8ebd0914bc22a13fd10a92e33c5a9d93240d0383b5e210 | ||
| 035 | |a (KEY)0012464820150000119000000856effectsoffluoxetineonbehaviorantioxidantenzymesyst | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 333.7 |q DNB |
| 084 | |a AR 10100 |q AVZ |2 rvk | ||
| 084 | |a 38.32 |2 bkl | ||
| 084 | |a 35.00 |2 bkl | ||
| 100 | 1 | |a Chen, Huihui |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effects of fluoxetine on behavior, antioxidant enzyme systems, and multixenobiotic resistance in the Asian clam Corbicula fluminea |
| 264 | 1 | |c 2015 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 520 | |a Fluoxetine (FLX), a selective serotonin reuptake inhibitor, is widespread in aquatic environments. Despite its reported effects on behavior and reproduction in aquatic species, little is known about the effects of FLX on cellular detoxification and defense system in bivalves. Here, the adult Asian clam (Corbicula fluminea) was exposed to 0.5, 5, and 50 μg L(-1) FLX for 30 d. Siphoning behavior was inhibited by treatment with 50 μg L(-1) FLX. Additionally, superoxide dismutase (SOD) activity in the gills and digestive glands significantly decreased (p<0.05) with 5 and 50 μg L(-1) FLX treatments, whereas catalase (CAT) activity and malondialdehyde (MDA) content markedly increased (p<0.05). Moreover, transcription of thioredoxin reductase (TR), glutathione peroxidase (GPx) and Glutathione S-transferase pi class (GSTpi) was significantly upregulated (p<0.05), whereas glutathione reductase (GR) was markedly downregulated (p<0.05). These findings suggest that FLX affects behavior and induces oxidative stress in C. fluminea. The downregulation of ATP-binding cassette (ABC) transportor genes (ABCB1, ABCC1 and ABCG2) transporter genes indicated that FLX might suppress the multixenobiotic resistance (MXR) system in C. fluminea. Our results provide new insights into the adverse effects of FLX on the cellular detoxification and MXR system of C. fluminea. | ||
| 540 | |a Nutzungsrecht: Copyright © 2014 Elsevier Ltd. All rights reserved. | ||
| 650 | 4 | |a Malondialdehyde - metabolism | |
| 650 | 4 | |a Water Pollutants, Chemical - analysis | |
| 650 | 4 | |a Thioredoxin-Disulfide Reductase - metabolism | |
| 650 | 4 | |a Superoxide Dismutase - metabolism | |
| 650 | 4 | |a Behavior, Animal - drug effects | |
| 650 | 4 | |a Corbicula - genetics | |
| 650 | 4 | |a Gills - metabolism | |
| 650 | 4 | |a Water Pollutants, Chemical - toxicity | |
| 650 | 4 | |a Corbicula - drug effects | |
| 650 | 4 | |a Glutathione Peroxidase - metabolism | |
| 650 | 4 | |a Catalase - metabolism | |
| 650 | 4 | |a Antioxidants - metabolism | |
| 650 | 4 | |a DNA Primers - genetics | |
| 650 | 4 | |a Fluoxetine - metabolism | |
| 650 | 4 | |a Oxidative Stress - drug effects | |
| 650 | 4 | |a Glutathione Reductase - metabolism | |
| 650 | 4 | |a Fluoxetine - toxicity | |
| 650 | 4 | |a DNA, Complementary - genetics | |
| 700 | 1 | |a Zha, Jinmiao |4 oth | |
| 700 | 1 | |a Yuan, Lilai |4 oth | |
| 700 | 1 | |a Wang, Zijian |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t Chemosphere |d Kidlington, Oxford : Elsevier Science, 1972 |g 119(2015), Seite 856-862 |w (DE-627)129288586 |w (DE-600)120089-6 |w (DE-576)014470187 |x 0045-6535 |7 nnns |
| 773 | 1 | 8 | |g volume:119 |g year:2015 |g pages:856-862 |
| 856 | 4 | 1 | |u http://dx.doi.org/10.1016/j.chemosphere.2014.08.062 |3 Volltext |
| 856 | 4 | 2 | |u http://www.ncbi.nlm.nih.gov/pubmed/25240949 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_OLC | ||
| 912 | |a SSG-OLC-UMW | ||
| 912 | |a SSG-OLC-TEC | ||
| 912 | |a SSG-OLC-CHE | ||
| 912 | |a SSG-OLC-GEO | ||
| 912 | |a SSG-OLC-PHA | ||
| 912 | |a SSG-OLC-DE-84 | ||
| 912 | |a SSG-OPC-GGO | ||
| 912 | |a GBV_ILN_21 | ||
| 912 | |a GBV_ILN_70 | ||
| 912 | |a GBV_ILN_4012 | ||
| 936 | r | v | |a AR 10100 |
| 936 | b | k | |a 38.32 |q AVZ |
| 936 | b | k | |a 35.00 |q AVZ |
| 951 | |a AR | ||
| 952 | |d 119 |j 2015 |h 856-862 | ||
| author_variant |
h c hc |
|---|---|
| matchkey_str |
article:00456535:2015----::fetofuxtnobhvoatoiatnyeytmadutxnboirssacit |
| hierarchy_sort_str |
2015 |
| bklnumber |
38.32 35.00 |
| publishDate |
2015 |
| allfields |
10.1016/j.chemosphere.2014.08.062 doi PQ20160617 (DE-627)OLC1963057724 (DE-599)GBVOLC1963057724 (PRQ)c1916-a350b9b5f853f8c0ffb8ebd0914bc22a13fd10a92e33c5a9d93240d0383b5e210 (KEY)0012464820150000119000000856effectsoffluoxetineonbehaviorantioxidantenzymesyst DE-627 ger DE-627 rakwb eng 333.7 DNB AR 10100 AVZ rvk 38.32 bkl 35.00 bkl Chen, Huihui verfasserin aut Effects of fluoxetine on behavior, antioxidant enzyme systems, and multixenobiotic resistance in the Asian clam Corbicula fluminea 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Fluoxetine (FLX), a selective serotonin reuptake inhibitor, is widespread in aquatic environments. Despite its reported effects on behavior and reproduction in aquatic species, little is known about the effects of FLX on cellular detoxification and defense system in bivalves. Here, the adult Asian clam (Corbicula fluminea) was exposed to 0.5, 5, and 50 μg L(-1) FLX for 30 d. Siphoning behavior was inhibited by treatment with 50 μg L(-1) FLX. Additionally, superoxide dismutase (SOD) activity in the gills and digestive glands significantly decreased (p<0.05) with 5 and 50 μg L(-1) FLX treatments, whereas catalase (CAT) activity and malondialdehyde (MDA) content markedly increased (p<0.05). Moreover, transcription of thioredoxin reductase (TR), glutathione peroxidase (GPx) and Glutathione S-transferase pi class (GSTpi) was significantly upregulated (p<0.05), whereas glutathione reductase (GR) was markedly downregulated (p<0.05). These findings suggest that FLX affects behavior and induces oxidative stress in C. fluminea. The downregulation of ATP-binding cassette (ABC) transportor genes (ABCB1, ABCC1 and ABCG2) transporter genes indicated that FLX might suppress the multixenobiotic resistance (MXR) system in C. fluminea. Our results provide new insights into the adverse effects of FLX on the cellular detoxification and MXR system of C. fluminea. Nutzungsrecht: Copyright © 2014 Elsevier Ltd. All rights reserved. Malondialdehyde - metabolism Water Pollutants, Chemical - analysis Thioredoxin-Disulfide Reductase - metabolism Superoxide Dismutase - metabolism Behavior, Animal - drug effects Corbicula - genetics Gills - metabolism Water Pollutants, Chemical - toxicity Corbicula - drug effects Glutathione Peroxidase - metabolism Catalase - metabolism Antioxidants - metabolism DNA Primers - genetics Fluoxetine - metabolism Oxidative Stress - drug effects Glutathione Reductase - metabolism Fluoxetine - toxicity DNA, Complementary - genetics Zha, Jinmiao oth Yuan, Lilai oth Wang, Zijian oth Enthalten in Chemosphere Kidlington, Oxford : Elsevier Science, 1972 119(2015), Seite 856-862 (DE-627)129288586 (DE-600)120089-6 (DE-576)014470187 0045-6535 nnns volume:119 year:2015 pages:856-862 http://dx.doi.org/10.1016/j.chemosphere.2014.08.062 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25240949 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-GEO SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-GGO GBV_ILN_21 GBV_ILN_70 GBV_ILN_4012 AR 10100 38.32 AVZ 35.00 AVZ AR 119 2015 856-862 |
| spelling |
10.1016/j.chemosphere.2014.08.062 doi PQ20160617 (DE-627)OLC1963057724 (DE-599)GBVOLC1963057724 (PRQ)c1916-a350b9b5f853f8c0ffb8ebd0914bc22a13fd10a92e33c5a9d93240d0383b5e210 (KEY)0012464820150000119000000856effectsoffluoxetineonbehaviorantioxidantenzymesyst DE-627 ger DE-627 rakwb eng 333.7 DNB AR 10100 AVZ rvk 38.32 bkl 35.00 bkl Chen, Huihui verfasserin aut Effects of fluoxetine on behavior, antioxidant enzyme systems, and multixenobiotic resistance in the Asian clam Corbicula fluminea 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Fluoxetine (FLX), a selective serotonin reuptake inhibitor, is widespread in aquatic environments. Despite its reported effects on behavior and reproduction in aquatic species, little is known about the effects of FLX on cellular detoxification and defense system in bivalves. Here, the adult Asian clam (Corbicula fluminea) was exposed to 0.5, 5, and 50 μg L(-1) FLX for 30 d. Siphoning behavior was inhibited by treatment with 50 μg L(-1) FLX. Additionally, superoxide dismutase (SOD) activity in the gills and digestive glands significantly decreased (p<0.05) with 5 and 50 μg L(-1) FLX treatments, whereas catalase (CAT) activity and malondialdehyde (MDA) content markedly increased (p<0.05). Moreover, transcription of thioredoxin reductase (TR), glutathione peroxidase (GPx) and Glutathione S-transferase pi class (GSTpi) was significantly upregulated (p<0.05), whereas glutathione reductase (GR) was markedly downregulated (p<0.05). These findings suggest that FLX affects behavior and induces oxidative stress in C. fluminea. The downregulation of ATP-binding cassette (ABC) transportor genes (ABCB1, ABCC1 and ABCG2) transporter genes indicated that FLX might suppress the multixenobiotic resistance (MXR) system in C. fluminea. Our results provide new insights into the adverse effects of FLX on the cellular detoxification and MXR system of C. fluminea. Nutzungsrecht: Copyright © 2014 Elsevier Ltd. All rights reserved. Malondialdehyde - metabolism Water Pollutants, Chemical - analysis Thioredoxin-Disulfide Reductase - metabolism Superoxide Dismutase - metabolism Behavior, Animal - drug effects Corbicula - genetics Gills - metabolism Water Pollutants, Chemical - toxicity Corbicula - drug effects Glutathione Peroxidase - metabolism Catalase - metabolism Antioxidants - metabolism DNA Primers - genetics Fluoxetine - metabolism Oxidative Stress - drug effects Glutathione Reductase - metabolism Fluoxetine - toxicity DNA, Complementary - genetics Zha, Jinmiao oth Yuan, Lilai oth Wang, Zijian oth Enthalten in Chemosphere Kidlington, Oxford : Elsevier Science, 1972 119(2015), Seite 856-862 (DE-627)129288586 (DE-600)120089-6 (DE-576)014470187 0045-6535 nnns volume:119 year:2015 pages:856-862 http://dx.doi.org/10.1016/j.chemosphere.2014.08.062 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25240949 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-GEO SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-GGO GBV_ILN_21 GBV_ILN_70 GBV_ILN_4012 AR 10100 38.32 AVZ 35.00 AVZ AR 119 2015 856-862 |
| allfields_unstemmed |
10.1016/j.chemosphere.2014.08.062 doi PQ20160617 (DE-627)OLC1963057724 (DE-599)GBVOLC1963057724 (PRQ)c1916-a350b9b5f853f8c0ffb8ebd0914bc22a13fd10a92e33c5a9d93240d0383b5e210 (KEY)0012464820150000119000000856effectsoffluoxetineonbehaviorantioxidantenzymesyst DE-627 ger DE-627 rakwb eng 333.7 DNB AR 10100 AVZ rvk 38.32 bkl 35.00 bkl Chen, Huihui verfasserin aut Effects of fluoxetine on behavior, antioxidant enzyme systems, and multixenobiotic resistance in the Asian clam Corbicula fluminea 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Fluoxetine (FLX), a selective serotonin reuptake inhibitor, is widespread in aquatic environments. Despite its reported effects on behavior and reproduction in aquatic species, little is known about the effects of FLX on cellular detoxification and defense system in bivalves. Here, the adult Asian clam (Corbicula fluminea) was exposed to 0.5, 5, and 50 μg L(-1) FLX for 30 d. Siphoning behavior was inhibited by treatment with 50 μg L(-1) FLX. Additionally, superoxide dismutase (SOD) activity in the gills and digestive glands significantly decreased (p<0.05) with 5 and 50 μg L(-1) FLX treatments, whereas catalase (CAT) activity and malondialdehyde (MDA) content markedly increased (p<0.05). Moreover, transcription of thioredoxin reductase (TR), glutathione peroxidase (GPx) and Glutathione S-transferase pi class (GSTpi) was significantly upregulated (p<0.05), whereas glutathione reductase (GR) was markedly downregulated (p<0.05). These findings suggest that FLX affects behavior and induces oxidative stress in C. fluminea. The downregulation of ATP-binding cassette (ABC) transportor genes (ABCB1, ABCC1 and ABCG2) transporter genes indicated that FLX might suppress the multixenobiotic resistance (MXR) system in C. fluminea. Our results provide new insights into the adverse effects of FLX on the cellular detoxification and MXR system of C. fluminea. Nutzungsrecht: Copyright © 2014 Elsevier Ltd. All rights reserved. Malondialdehyde - metabolism Water Pollutants, Chemical - analysis Thioredoxin-Disulfide Reductase - metabolism Superoxide Dismutase - metabolism Behavior, Animal - drug effects Corbicula - genetics Gills - metabolism Water Pollutants, Chemical - toxicity Corbicula - drug effects Glutathione Peroxidase - metabolism Catalase - metabolism Antioxidants - metabolism DNA Primers - genetics Fluoxetine - metabolism Oxidative Stress - drug effects Glutathione Reductase - metabolism Fluoxetine - toxicity DNA, Complementary - genetics Zha, Jinmiao oth Yuan, Lilai oth Wang, Zijian oth Enthalten in Chemosphere Kidlington, Oxford : Elsevier Science, 1972 119(2015), Seite 856-862 (DE-627)129288586 (DE-600)120089-6 (DE-576)014470187 0045-6535 nnns volume:119 year:2015 pages:856-862 http://dx.doi.org/10.1016/j.chemosphere.2014.08.062 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25240949 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-GEO SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-GGO GBV_ILN_21 GBV_ILN_70 GBV_ILN_4012 AR 10100 38.32 AVZ 35.00 AVZ AR 119 2015 856-862 |
| allfieldsGer |
10.1016/j.chemosphere.2014.08.062 doi PQ20160617 (DE-627)OLC1963057724 (DE-599)GBVOLC1963057724 (PRQ)c1916-a350b9b5f853f8c0ffb8ebd0914bc22a13fd10a92e33c5a9d93240d0383b5e210 (KEY)0012464820150000119000000856effectsoffluoxetineonbehaviorantioxidantenzymesyst DE-627 ger DE-627 rakwb eng 333.7 DNB AR 10100 AVZ rvk 38.32 bkl 35.00 bkl Chen, Huihui verfasserin aut Effects of fluoxetine on behavior, antioxidant enzyme systems, and multixenobiotic resistance in the Asian clam Corbicula fluminea 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Fluoxetine (FLX), a selective serotonin reuptake inhibitor, is widespread in aquatic environments. Despite its reported effects on behavior and reproduction in aquatic species, little is known about the effects of FLX on cellular detoxification and defense system in bivalves. Here, the adult Asian clam (Corbicula fluminea) was exposed to 0.5, 5, and 50 μg L(-1) FLX for 30 d. Siphoning behavior was inhibited by treatment with 50 μg L(-1) FLX. Additionally, superoxide dismutase (SOD) activity in the gills and digestive glands significantly decreased (p<0.05) with 5 and 50 μg L(-1) FLX treatments, whereas catalase (CAT) activity and malondialdehyde (MDA) content markedly increased (p<0.05). Moreover, transcription of thioredoxin reductase (TR), glutathione peroxidase (GPx) and Glutathione S-transferase pi class (GSTpi) was significantly upregulated (p<0.05), whereas glutathione reductase (GR) was markedly downregulated (p<0.05). These findings suggest that FLX affects behavior and induces oxidative stress in C. fluminea. The downregulation of ATP-binding cassette (ABC) transportor genes (ABCB1, ABCC1 and ABCG2) transporter genes indicated that FLX might suppress the multixenobiotic resistance (MXR) system in C. fluminea. Our results provide new insights into the adverse effects of FLX on the cellular detoxification and MXR system of C. fluminea. Nutzungsrecht: Copyright © 2014 Elsevier Ltd. All rights reserved. Malondialdehyde - metabolism Water Pollutants, Chemical - analysis Thioredoxin-Disulfide Reductase - metabolism Superoxide Dismutase - metabolism Behavior, Animal - drug effects Corbicula - genetics Gills - metabolism Water Pollutants, Chemical - toxicity Corbicula - drug effects Glutathione Peroxidase - metabolism Catalase - metabolism Antioxidants - metabolism DNA Primers - genetics Fluoxetine - metabolism Oxidative Stress - drug effects Glutathione Reductase - metabolism Fluoxetine - toxicity DNA, Complementary - genetics Zha, Jinmiao oth Yuan, Lilai oth Wang, Zijian oth Enthalten in Chemosphere Kidlington, Oxford : Elsevier Science, 1972 119(2015), Seite 856-862 (DE-627)129288586 (DE-600)120089-6 (DE-576)014470187 0045-6535 nnns volume:119 year:2015 pages:856-862 http://dx.doi.org/10.1016/j.chemosphere.2014.08.062 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25240949 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-GEO SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-GGO GBV_ILN_21 GBV_ILN_70 GBV_ILN_4012 AR 10100 38.32 AVZ 35.00 AVZ AR 119 2015 856-862 |
| allfieldsSound |
10.1016/j.chemosphere.2014.08.062 doi PQ20160617 (DE-627)OLC1963057724 (DE-599)GBVOLC1963057724 (PRQ)c1916-a350b9b5f853f8c0ffb8ebd0914bc22a13fd10a92e33c5a9d93240d0383b5e210 (KEY)0012464820150000119000000856effectsoffluoxetineonbehaviorantioxidantenzymesyst DE-627 ger DE-627 rakwb eng 333.7 DNB AR 10100 AVZ rvk 38.32 bkl 35.00 bkl Chen, Huihui verfasserin aut Effects of fluoxetine on behavior, antioxidant enzyme systems, and multixenobiotic resistance in the Asian clam Corbicula fluminea 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Fluoxetine (FLX), a selective serotonin reuptake inhibitor, is widespread in aquatic environments. Despite its reported effects on behavior and reproduction in aquatic species, little is known about the effects of FLX on cellular detoxification and defense system in bivalves. Here, the adult Asian clam (Corbicula fluminea) was exposed to 0.5, 5, and 50 μg L(-1) FLX for 30 d. Siphoning behavior was inhibited by treatment with 50 μg L(-1) FLX. Additionally, superoxide dismutase (SOD) activity in the gills and digestive glands significantly decreased (p<0.05) with 5 and 50 μg L(-1) FLX treatments, whereas catalase (CAT) activity and malondialdehyde (MDA) content markedly increased (p<0.05). Moreover, transcription of thioredoxin reductase (TR), glutathione peroxidase (GPx) and Glutathione S-transferase pi class (GSTpi) was significantly upregulated (p<0.05), whereas glutathione reductase (GR) was markedly downregulated (p<0.05). These findings suggest that FLX affects behavior and induces oxidative stress in C. fluminea. The downregulation of ATP-binding cassette (ABC) transportor genes (ABCB1, ABCC1 and ABCG2) transporter genes indicated that FLX might suppress the multixenobiotic resistance (MXR) system in C. fluminea. Our results provide new insights into the adverse effects of FLX on the cellular detoxification and MXR system of C. fluminea. Nutzungsrecht: Copyright © 2014 Elsevier Ltd. All rights reserved. Malondialdehyde - metabolism Water Pollutants, Chemical - analysis Thioredoxin-Disulfide Reductase - metabolism Superoxide Dismutase - metabolism Behavior, Animal - drug effects Corbicula - genetics Gills - metabolism Water Pollutants, Chemical - toxicity Corbicula - drug effects Glutathione Peroxidase - metabolism Catalase - metabolism Antioxidants - metabolism DNA Primers - genetics Fluoxetine - metabolism Oxidative Stress - drug effects Glutathione Reductase - metabolism Fluoxetine - toxicity DNA, Complementary - genetics Zha, Jinmiao oth Yuan, Lilai oth Wang, Zijian oth Enthalten in Chemosphere Kidlington, Oxford : Elsevier Science, 1972 119(2015), Seite 856-862 (DE-627)129288586 (DE-600)120089-6 (DE-576)014470187 0045-6535 nnns volume:119 year:2015 pages:856-862 http://dx.doi.org/10.1016/j.chemosphere.2014.08.062 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25240949 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-GEO SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-GGO GBV_ILN_21 GBV_ILN_70 GBV_ILN_4012 AR 10100 38.32 AVZ 35.00 AVZ AR 119 2015 856-862 |
| language |
English |
| source |
Enthalten in Chemosphere 119(2015), Seite 856-862 volume:119 year:2015 pages:856-862 |
| sourceStr |
Enthalten in Chemosphere 119(2015), Seite 856-862 volume:119 year:2015 pages:856-862 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| topic_facet |
Malondialdehyde - metabolism Water Pollutants, Chemical - analysis Thioredoxin-Disulfide Reductase - metabolism Superoxide Dismutase - metabolism Behavior, Animal - drug effects Corbicula - genetics Gills - metabolism Water Pollutants, Chemical - toxicity Corbicula - drug effects Glutathione Peroxidase - metabolism Catalase - metabolism Antioxidants - metabolism DNA Primers - genetics Fluoxetine - metabolism Oxidative Stress - drug effects Glutathione Reductase - metabolism Fluoxetine - toxicity DNA, Complementary - genetics |
| dewey-raw |
333.7 |
| isfreeaccess_bool |
false |
| container_title |
Chemosphere |
| authorswithroles_txt_mv |
Chen, Huihui @@aut@@ Zha, Jinmiao @@oth@@ Yuan, Lilai @@oth@@ Wang, Zijian @@oth@@ |
| publishDateDaySort_date |
2015-01-01T00:00:00Z |
| hierarchy_top_id |
129288586 |
| dewey-sort |
3333.7 |
| id |
OLC1963057724 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a2200265 4500</leader><controlfield tag="001">OLC1963057724</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230508074903.0</controlfield><controlfield tag="007">tu</controlfield><controlfield tag="008">160206s2015 xx ||||| 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.chemosphere.2014.08.062</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">PQ20160617</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)OLC1963057724</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBVOLC1963057724</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(PRQ)c1916-a350b9b5f853f8c0ffb8ebd0914bc22a13fd10a92e33c5a9d93240d0383b5e210</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(KEY)0012464820150000119000000856effectsoffluoxetineonbehaviorantioxidantenzymesyst</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">333.7</subfield><subfield code="q">DNB</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">AR 10100</subfield><subfield code="q">AVZ</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">38.32</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">35.00</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Chen, Huihui</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Effects of fluoxetine on behavior, antioxidant enzyme systems, and multixenobiotic resistance in the Asian clam Corbicula fluminea</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2015</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">ohne Hilfsmittel zu benutzen</subfield><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Band</subfield><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Fluoxetine (FLX), a selective serotonin reuptake inhibitor, is widespread in aquatic environments. Despite its reported effects on behavior and reproduction in aquatic species, little is known about the effects of FLX on cellular detoxification and defense system in bivalves. Here, the adult Asian clam (Corbicula fluminea) was exposed to 0.5, 5, and 50 μg L(-1) FLX for 30 d. Siphoning behavior was inhibited by treatment with 50 μg L(-1) FLX. Additionally, superoxide dismutase (SOD) activity in the gills and digestive glands significantly decreased (p<0.05) with 5 and 50 μg L(-1) FLX treatments, whereas catalase (CAT) activity and malondialdehyde (MDA) content markedly increased (p<0.05). Moreover, transcription of thioredoxin reductase (TR), glutathione peroxidase (GPx) and Glutathione S-transferase pi class (GSTpi) was significantly upregulated (p<0.05), whereas glutathione reductase (GR) was markedly downregulated (p<0.05). These findings suggest that FLX affects behavior and induces oxidative stress in C. fluminea. The downregulation of ATP-binding cassette (ABC) transportor genes (ABCB1, ABCC1 and ABCG2) transporter genes indicated that FLX might suppress the multixenobiotic resistance (MXR) system in C. fluminea. Our results provide new insights into the adverse effects of FLX on the cellular detoxification and MXR system of C. fluminea.</subfield></datafield><datafield tag="540" ind1=" " ind2=" "><subfield code="a">Nutzungsrecht: Copyright © 2014 Elsevier Ltd. All rights reserved.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Malondialdehyde - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Water Pollutants, Chemical - analysis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Thioredoxin-Disulfide Reductase - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Superoxide Dismutase - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Behavior, Animal - drug effects</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Corbicula - genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Gills - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Water Pollutants, Chemical - toxicity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Corbicula - drug effects</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Glutathione Peroxidase - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Catalase - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Antioxidants - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">DNA Primers - genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Fluoxetine - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Oxidative Stress - drug effects</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Glutathione Reductase - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Fluoxetine - toxicity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">DNA, Complementary - genetics</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zha, Jinmiao</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Yuan, Lilai</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wang, Zijian</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Chemosphere</subfield><subfield code="d">Kidlington, Oxford : Elsevier Science, 1972</subfield><subfield code="g">119(2015), Seite 856-862</subfield><subfield code="w">(DE-627)129288586</subfield><subfield code="w">(DE-600)120089-6</subfield><subfield code="w">(DE-576)014470187</subfield><subfield code="x">0045-6535</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:119</subfield><subfield code="g">year:2015</subfield><subfield code="g">pages:856-862</subfield></datafield><datafield tag="856" ind1="4" ind2="1"><subfield code="u">http://dx.doi.org/10.1016/j.chemosphere.2014.08.062</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">http://www.ncbi.nlm.nih.gov/pubmed/25240949</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_OLC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-UMW</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-TEC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-CHE</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-GEO</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-DE-84</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OPC-GGO</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_21</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="936" ind1="r" ind2="v"><subfield code="a">AR 10100</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">38.32</subfield><subfield code="q">AVZ</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">35.00</subfield><subfield code="q">AVZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">119</subfield><subfield code="j">2015</subfield><subfield code="h">856-862</subfield></datafield></record></collection>
|
| author |
Chen, Huihui |
| spellingShingle |
Chen, Huihui ddc 333.7 rvk AR 10100 bkl 38.32 bkl 35.00 misc Malondialdehyde - metabolism misc Water Pollutants, Chemical - analysis misc Thioredoxin-Disulfide Reductase - metabolism misc Superoxide Dismutase - metabolism misc Behavior, Animal - drug effects misc Corbicula - genetics misc Gills - metabolism misc Water Pollutants, Chemical - toxicity misc Corbicula - drug effects misc Glutathione Peroxidase - metabolism misc Catalase - metabolism misc Antioxidants - metabolism misc DNA Primers - genetics misc Fluoxetine - metabolism misc Oxidative Stress - drug effects misc Glutathione Reductase - metabolism misc Fluoxetine - toxicity misc DNA, Complementary - genetics Effects of fluoxetine on behavior, antioxidant enzyme systems, and multixenobiotic resistance in the Asian clam Corbicula fluminea |
| authorStr |
Chen, Huihui |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)129288586 |
| format |
Article |
| dewey-ones |
333 - Economics of land & energy |
| delete_txt_mv |
keep |
| author_role |
aut |
| collection |
OLC |
| remote_str |
false |
| illustrated |
Not Illustrated |
| issn |
0045-6535 |
| topic_title |
333.7 DNB AR 10100 AVZ rvk 38.32 bkl 35.00 bkl Effects of fluoxetine on behavior, antioxidant enzyme systems, and multixenobiotic resistance in the Asian clam Corbicula fluminea Malondialdehyde - metabolism Water Pollutants, Chemical - analysis Thioredoxin-Disulfide Reductase - metabolism Superoxide Dismutase - metabolism Behavior, Animal - drug effects Corbicula - genetics Gills - metabolism Water Pollutants, Chemical - toxicity Corbicula - drug effects Glutathione Peroxidase - metabolism Catalase - metabolism Antioxidants - metabolism DNA Primers - genetics Fluoxetine - metabolism Oxidative Stress - drug effects Glutathione Reductase - metabolism Fluoxetine - toxicity DNA, Complementary - genetics |
| topic |
ddc 333.7 rvk AR 10100 bkl 38.32 bkl 35.00 misc Malondialdehyde - metabolism misc Water Pollutants, Chemical - analysis misc Thioredoxin-Disulfide Reductase - metabolism misc Superoxide Dismutase - metabolism misc Behavior, Animal - drug effects misc Corbicula - genetics misc Gills - metabolism misc Water Pollutants, Chemical - toxicity misc Corbicula - drug effects misc Glutathione Peroxidase - metabolism misc Catalase - metabolism misc Antioxidants - metabolism misc DNA Primers - genetics misc Fluoxetine - metabolism misc Oxidative Stress - drug effects misc Glutathione Reductase - metabolism misc Fluoxetine - toxicity misc DNA, Complementary - genetics |
| topic_unstemmed |
ddc 333.7 rvk AR 10100 bkl 38.32 bkl 35.00 misc Malondialdehyde - metabolism misc Water Pollutants, Chemical - analysis misc Thioredoxin-Disulfide Reductase - metabolism misc Superoxide Dismutase - metabolism misc Behavior, Animal - drug effects misc Corbicula - genetics misc Gills - metabolism misc Water Pollutants, Chemical - toxicity misc Corbicula - drug effects misc Glutathione Peroxidase - metabolism misc Catalase - metabolism misc Antioxidants - metabolism misc DNA Primers - genetics misc Fluoxetine - metabolism misc Oxidative Stress - drug effects misc Glutathione Reductase - metabolism misc Fluoxetine - toxicity misc DNA, Complementary - genetics |
| topic_browse |
ddc 333.7 rvk AR 10100 bkl 38.32 bkl 35.00 misc Malondialdehyde - metabolism misc Water Pollutants, Chemical - analysis misc Thioredoxin-Disulfide Reductase - metabolism misc Superoxide Dismutase - metabolism misc Behavior, Animal - drug effects misc Corbicula - genetics misc Gills - metabolism misc Water Pollutants, Chemical - toxicity misc Corbicula - drug effects misc Glutathione Peroxidase - metabolism misc Catalase - metabolism misc Antioxidants - metabolism misc DNA Primers - genetics misc Fluoxetine - metabolism misc Oxidative Stress - drug effects misc Glutathione Reductase - metabolism misc Fluoxetine - toxicity misc DNA, Complementary - genetics |
| format_facet |
Aufsätze Gedruckte Aufsätze |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
nc |
| author2_variant |
j z jz l y ly z w zw |
| hierarchy_parent_title |
Chemosphere |
| hierarchy_parent_id |
129288586 |
| dewey-tens |
330 - Economics |
| hierarchy_top_title |
Chemosphere |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)129288586 (DE-600)120089-6 (DE-576)014470187 |
| title |
Effects of fluoxetine on behavior, antioxidant enzyme systems, and multixenobiotic resistance in the Asian clam Corbicula fluminea |
| ctrlnum |
(DE-627)OLC1963057724 (DE-599)GBVOLC1963057724 (PRQ)c1916-a350b9b5f853f8c0ffb8ebd0914bc22a13fd10a92e33c5a9d93240d0383b5e210 (KEY)0012464820150000119000000856effectsoffluoxetineonbehaviorantioxidantenzymesyst |
| title_full |
Effects of fluoxetine on behavior, antioxidant enzyme systems, and multixenobiotic resistance in the Asian clam Corbicula fluminea |
| author_sort |
Chen, Huihui |
| journal |
Chemosphere |
| journalStr |
Chemosphere |
| lang_code |
eng |
| isOA_bool |
false |
| dewey-hundreds |
300 - Social sciences |
| recordtype |
marc |
| publishDateSort |
2015 |
| contenttype_str_mv |
txt |
| container_start_page |
856 |
| author_browse |
Chen, Huihui |
| container_volume |
119 |
| class |
333.7 DNB AR 10100 AVZ rvk 38.32 bkl 35.00 bkl |
| format_se |
Aufsätze |
| author-letter |
Chen, Huihui |
| doi_str_mv |
10.1016/j.chemosphere.2014.08.062 |
| dewey-full |
333.7 |
| title_sort |
effects of fluoxetine on behavior, antioxidant enzyme systems, and multixenobiotic resistance in the asian clam corbicula fluminea |
| title_auth |
Effects of fluoxetine on behavior, antioxidant enzyme systems, and multixenobiotic resistance in the Asian clam Corbicula fluminea |
| abstract |
Fluoxetine (FLX), a selective serotonin reuptake inhibitor, is widespread in aquatic environments. Despite its reported effects on behavior and reproduction in aquatic species, little is known about the effects of FLX on cellular detoxification and defense system in bivalves. Here, the adult Asian clam (Corbicula fluminea) was exposed to 0.5, 5, and 50 μg L(-1) FLX for 30 d. Siphoning behavior was inhibited by treatment with 50 μg L(-1) FLX. Additionally, superoxide dismutase (SOD) activity in the gills and digestive glands significantly decreased (p<0.05) with 5 and 50 μg L(-1) FLX treatments, whereas catalase (CAT) activity and malondialdehyde (MDA) content markedly increased (p<0.05). Moreover, transcription of thioredoxin reductase (TR), glutathione peroxidase (GPx) and Glutathione S-transferase pi class (GSTpi) was significantly upregulated (p<0.05), whereas glutathione reductase (GR) was markedly downregulated (p<0.05). These findings suggest that FLX affects behavior and induces oxidative stress in C. fluminea. The downregulation of ATP-binding cassette (ABC) transportor genes (ABCB1, ABCC1 and ABCG2) transporter genes indicated that FLX might suppress the multixenobiotic resistance (MXR) system in C. fluminea. Our results provide new insights into the adverse effects of FLX on the cellular detoxification and MXR system of C. fluminea. |
| abstractGer |
Fluoxetine (FLX), a selective serotonin reuptake inhibitor, is widespread in aquatic environments. Despite its reported effects on behavior and reproduction in aquatic species, little is known about the effects of FLX on cellular detoxification and defense system in bivalves. Here, the adult Asian clam (Corbicula fluminea) was exposed to 0.5, 5, and 50 μg L(-1) FLX for 30 d. Siphoning behavior was inhibited by treatment with 50 μg L(-1) FLX. Additionally, superoxide dismutase (SOD) activity in the gills and digestive glands significantly decreased (p<0.05) with 5 and 50 μg L(-1) FLX treatments, whereas catalase (CAT) activity and malondialdehyde (MDA) content markedly increased (p<0.05). Moreover, transcription of thioredoxin reductase (TR), glutathione peroxidase (GPx) and Glutathione S-transferase pi class (GSTpi) was significantly upregulated (p<0.05), whereas glutathione reductase (GR) was markedly downregulated (p<0.05). These findings suggest that FLX affects behavior and induces oxidative stress in C. fluminea. The downregulation of ATP-binding cassette (ABC) transportor genes (ABCB1, ABCC1 and ABCG2) transporter genes indicated that FLX might suppress the multixenobiotic resistance (MXR) system in C. fluminea. Our results provide new insights into the adverse effects of FLX on the cellular detoxification and MXR system of C. fluminea. |
| abstract_unstemmed |
Fluoxetine (FLX), a selective serotonin reuptake inhibitor, is widespread in aquatic environments. Despite its reported effects on behavior and reproduction in aquatic species, little is known about the effects of FLX on cellular detoxification and defense system in bivalves. Here, the adult Asian clam (Corbicula fluminea) was exposed to 0.5, 5, and 50 μg L(-1) FLX for 30 d. Siphoning behavior was inhibited by treatment with 50 μg L(-1) FLX. Additionally, superoxide dismutase (SOD) activity in the gills and digestive glands significantly decreased (p<0.05) with 5 and 50 μg L(-1) FLX treatments, whereas catalase (CAT) activity and malondialdehyde (MDA) content markedly increased (p<0.05). Moreover, transcription of thioredoxin reductase (TR), glutathione peroxidase (GPx) and Glutathione S-transferase pi class (GSTpi) was significantly upregulated (p<0.05), whereas glutathione reductase (GR) was markedly downregulated (p<0.05). These findings suggest that FLX affects behavior and induces oxidative stress in C. fluminea. The downregulation of ATP-binding cassette (ABC) transportor genes (ABCB1, ABCC1 and ABCG2) transporter genes indicated that FLX might suppress the multixenobiotic resistance (MXR) system in C. fluminea. Our results provide new insights into the adverse effects of FLX on the cellular detoxification and MXR system of C. fluminea. |
| collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-GEO SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-GGO GBV_ILN_21 GBV_ILN_70 GBV_ILN_4012 |
| title_short |
Effects of fluoxetine on behavior, antioxidant enzyme systems, and multixenobiotic resistance in the Asian clam Corbicula fluminea |
| url |
http://dx.doi.org/10.1016/j.chemosphere.2014.08.062 http://www.ncbi.nlm.nih.gov/pubmed/25240949 |
| remote_bool |
false |
| author2 |
Zha, Jinmiao Yuan, Lilai Wang, Zijian |
| author2Str |
Zha, Jinmiao Yuan, Lilai Wang, Zijian |
| ppnlink |
129288586 |
| mediatype_str_mv |
n |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth oth oth |
| doi_str |
10.1016/j.chemosphere.2014.08.062 |
| up_date |
2024-07-04T04:52:54.722Z |
| _version_ |
1803622835515555840 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a2200265 4500</leader><controlfield tag="001">OLC1963057724</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230508074903.0</controlfield><controlfield tag="007">tu</controlfield><controlfield tag="008">160206s2015 xx ||||| 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.chemosphere.2014.08.062</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">PQ20160617</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)OLC1963057724</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBVOLC1963057724</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(PRQ)c1916-a350b9b5f853f8c0ffb8ebd0914bc22a13fd10a92e33c5a9d93240d0383b5e210</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(KEY)0012464820150000119000000856effectsoffluoxetineonbehaviorantioxidantenzymesyst</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">333.7</subfield><subfield code="q">DNB</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">AR 10100</subfield><subfield code="q">AVZ</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">38.32</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">35.00</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Chen, Huihui</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Effects of fluoxetine on behavior, antioxidant enzyme systems, and multixenobiotic resistance in the Asian clam Corbicula fluminea</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2015</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">ohne Hilfsmittel zu benutzen</subfield><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Band</subfield><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Fluoxetine (FLX), a selective serotonin reuptake inhibitor, is widespread in aquatic environments. Despite its reported effects on behavior and reproduction in aquatic species, little is known about the effects of FLX on cellular detoxification and defense system in bivalves. Here, the adult Asian clam (Corbicula fluminea) was exposed to 0.5, 5, and 50 μg L(-1) FLX for 30 d. Siphoning behavior was inhibited by treatment with 50 μg L(-1) FLX. Additionally, superoxide dismutase (SOD) activity in the gills and digestive glands significantly decreased (p<0.05) with 5 and 50 μg L(-1) FLX treatments, whereas catalase (CAT) activity and malondialdehyde (MDA) content markedly increased (p<0.05). Moreover, transcription of thioredoxin reductase (TR), glutathione peroxidase (GPx) and Glutathione S-transferase pi class (GSTpi) was significantly upregulated (p<0.05), whereas glutathione reductase (GR) was markedly downregulated (p<0.05). These findings suggest that FLX affects behavior and induces oxidative stress in C. fluminea. The downregulation of ATP-binding cassette (ABC) transportor genes (ABCB1, ABCC1 and ABCG2) transporter genes indicated that FLX might suppress the multixenobiotic resistance (MXR) system in C. fluminea. Our results provide new insights into the adverse effects of FLX on the cellular detoxification and MXR system of C. fluminea.</subfield></datafield><datafield tag="540" ind1=" " ind2=" "><subfield code="a">Nutzungsrecht: Copyright © 2014 Elsevier Ltd. All rights reserved.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Malondialdehyde - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Water Pollutants, Chemical - analysis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Thioredoxin-Disulfide Reductase - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Superoxide Dismutase - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Behavior, Animal - drug effects</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Corbicula - genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Gills - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Water Pollutants, Chemical - toxicity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Corbicula - drug effects</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Glutathione Peroxidase - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Catalase - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Antioxidants - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">DNA Primers - genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Fluoxetine - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Oxidative Stress - drug effects</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Glutathione Reductase - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Fluoxetine - toxicity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">DNA, Complementary - genetics</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zha, Jinmiao</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Yuan, Lilai</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wang, Zijian</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Chemosphere</subfield><subfield code="d">Kidlington, Oxford : Elsevier Science, 1972</subfield><subfield code="g">119(2015), Seite 856-862</subfield><subfield code="w">(DE-627)129288586</subfield><subfield code="w">(DE-600)120089-6</subfield><subfield code="w">(DE-576)014470187</subfield><subfield code="x">0045-6535</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:119</subfield><subfield code="g">year:2015</subfield><subfield code="g">pages:856-862</subfield></datafield><datafield tag="856" ind1="4" ind2="1"><subfield code="u">http://dx.doi.org/10.1016/j.chemosphere.2014.08.062</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">http://www.ncbi.nlm.nih.gov/pubmed/25240949</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_OLC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-UMW</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-TEC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-CHE</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-GEO</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-DE-84</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OPC-GGO</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_21</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="936" ind1="r" ind2="v"><subfield code="a">AR 10100</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">38.32</subfield><subfield code="q">AVZ</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">35.00</subfield><subfield code="q">AVZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">119</subfield><subfield code="j">2015</subfield><subfield code="h">856-862</subfield></datafield></record></collection>
|
| score |
7.3988304 |