The Effect of Ionizing Radiation on mRNA Levels of the DNA Damage Response Genes Rad9, Rad1 and Hus1 in Various Mouse Tissues

Rad9, Rad1 and Hus1 are essential genes conserved from yeast to humans. They form a heterotrimer complex (9-1-1 complex) that participates in the cell cycle checkpoint activation and DNA damage repair in eukaryotic cells. Rad9, Rad1 and Hus1 deficient cells are hypersensitive to ionizing radiation a...
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Autor*in:	Zhenya Zhang [verfasserIn] Zeyuan Cai Kaiming Li Yu Fang Lili An Zhishang Hu Shihua Wang Haiying Hang

Format:	Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	DNA Damage - genetics Gene Expression Regulation - radiation effects RNA, Messenger - metabolism Gamma Rays - adverse effects Exonucleases - genetics RNA, Messenger - genetics Cell Cycle Proteins - genetics

Systematik:	WA 15000

Übergeordnetes Werk:	Enthalten in: Radiation research - Lawrence, Kan. : Soc., 1954, 183(2015), 1, Seite 94-104
Übergeordnetes Werk:	volume:183 ; year:2015 ; number:1 ; pages:94-104

Links:	Volltext Link aufrufen Link aufrufen Link aufrufen

DOI / URN:	10.1667/RR13781.1

Katalog-ID:	OLC1963106644

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520			\|a Rad9, Rad1 and Hus1 are essential genes conserved from yeast to humans. They form a heterotrimer complex (9-1-1 complex) that participates in the cell cycle checkpoint activation and DNA damage repair in eukaryotic cells. Rad9, Rad1 and Hus1 deficient cells are hypersensitive to ionizing radiation and mouse cells deleted for anyone of the three genes are highly sensitive to the killing by gamma rays. We propose that ionizing radiation-induced transcription of these genes is a mechanism by which cells respond to radiation-induced damage. In this study we used quantitative real-time RT-PCR(qPCR) to analyze the mRNA levels of Rad9, Rad1 and Hus1 in various tissues isolated from mice that were either mock irradiated or exposed to 10 Gy gamma radiation. Our results indicated that the mRNA levels of Rad9, Rad1 and Hus1 genes were very different among these tissues, and we found high natural levels of mRNA in the spleen, lung, ovary and testis of mice before exposure to radiation. The mRNA levels of the three ge...
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spelling	10.1667/RR13781.1 doi PQ20160617 (DE-627)OLC1963106644 (DE-599)GBVOLC1963106644 (PRQ)b2298-d437b8fa592b788d6ff132382786d4882562c7e24179cb53605f4ee5d65dbcca0 (KEY)0012922420150000183000100094effectofionizingradiationonmrnalevelsofthednadamag DE-627 ger DE-627 rakwb eng 610 530 DNB WA 15000 AVZ rvk 44.64 bkl 44.40 bkl 33.30 bkl Zhenya Zhang verfasserin aut The Effect of Ionizing Radiation on mRNA Levels of the DNA Damage Response Genes Rad9, Rad1 and Hus1 in Various Mouse Tissues 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Rad9, Rad1 and Hus1 are essential genes conserved from yeast to humans. They form a heterotrimer complex (9-1-1 complex) that participates in the cell cycle checkpoint activation and DNA damage repair in eukaryotic cells. Rad9, Rad1 and Hus1 deficient cells are hypersensitive to ionizing radiation and mouse cells deleted for anyone of the three genes are highly sensitive to the killing by gamma rays. We propose that ionizing radiation-induced transcription of these genes is a mechanism by which cells respond to radiation-induced damage. In this study we used quantitative real-time RT-PCR(qPCR) to analyze the mRNA levels of Rad9, Rad1 and Hus1 in various tissues isolated from mice that were either mock irradiated or exposed to 10 Gy gamma radiation. Our results indicated that the mRNA levels of Rad9, Rad1 and Hus1 genes were very different among these tissues, and we found high natural levels of mRNA in the spleen, lung, ovary and testis of mice before exposure to radiation. The mRNA levels of the three ge... DNA Damage - genetics Gene Expression Regulation - radiation effects RNA, Messenger - metabolism Gamma Rays - adverse effects Exonucleases - genetics RNA, Messenger - genetics Cell Cycle Proteins - genetics Zeyuan Cai oth Kaiming Li oth Yu Fang oth Lili An oth Zhishang Hu oth Shihua Wang oth Haiying Hang oth Enthalten in Radiation research Lawrence, Kan. : Soc., 1954 183(2015), 1, Seite 94-104 (DE-627)129270644 (DE-600)80322-4 (DE-576)01446120X 0033-7587 nnns volume:183 year:2015 number:1 pages:94-104 http://dx.doi.org/10.1667/RR13781.1 Volltext http://www.bioone.org/doi/full/10.1667/RR13781.1 http://www.ncbi.nlm.nih.gov/pubmed/25564717 http://search.proquest.com/docview/1648380067 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-PHA GBV_ILN_170 GBV_ILN_2006 GBV_ILN_4112 GBV_ILN_4219 GBV_ILN_4256 GBV_ILN_4305 GBV_ILN_4306 WA 15000 44.64 AVZ 44.40 AVZ 33.30 AVZ AR 183 2015 1 94-104
allfields_unstemmed	10.1667/RR13781.1 doi PQ20160617 (DE-627)OLC1963106644 (DE-599)GBVOLC1963106644 (PRQ)b2298-d437b8fa592b788d6ff132382786d4882562c7e24179cb53605f4ee5d65dbcca0 (KEY)0012922420150000183000100094effectofionizingradiationonmrnalevelsofthednadamag DE-627 ger DE-627 rakwb eng 610 530 DNB WA 15000 AVZ rvk 44.64 bkl 44.40 bkl 33.30 bkl Zhenya Zhang verfasserin aut The Effect of Ionizing Radiation on mRNA Levels of the DNA Damage Response Genes Rad9, Rad1 and Hus1 in Various Mouse Tissues 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Rad9, Rad1 and Hus1 are essential genes conserved from yeast to humans. They form a heterotrimer complex (9-1-1 complex) that participates in the cell cycle checkpoint activation and DNA damage repair in eukaryotic cells. Rad9, Rad1 and Hus1 deficient cells are hypersensitive to ionizing radiation and mouse cells deleted for anyone of the three genes are highly sensitive to the killing by gamma rays. We propose that ionizing radiation-induced transcription of these genes is a mechanism by which cells respond to radiation-induced damage. In this study we used quantitative real-time RT-PCR(qPCR) to analyze the mRNA levels of Rad9, Rad1 and Hus1 in various tissues isolated from mice that were either mock irradiated or exposed to 10 Gy gamma radiation. Our results indicated that the mRNA levels of Rad9, Rad1 and Hus1 genes were very different among these tissues, and we found high natural levels of mRNA in the spleen, lung, ovary and testis of mice before exposure to radiation. The mRNA levels of the three ge... DNA Damage - genetics Gene Expression Regulation - radiation effects RNA, Messenger - metabolism Gamma Rays - adverse effects Exonucleases - genetics RNA, Messenger - genetics Cell Cycle Proteins - genetics Zeyuan Cai oth Kaiming Li oth Yu Fang oth Lili An oth Zhishang Hu oth Shihua Wang oth Haiying Hang oth Enthalten in Radiation research Lawrence, Kan. : Soc., 1954 183(2015), 1, Seite 94-104 (DE-627)129270644 (DE-600)80322-4 (DE-576)01446120X 0033-7587 nnns volume:183 year:2015 number:1 pages:94-104 http://dx.doi.org/10.1667/RR13781.1 Volltext http://www.bioone.org/doi/full/10.1667/RR13781.1 http://www.ncbi.nlm.nih.gov/pubmed/25564717 http://search.proquest.com/docview/1648380067 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-PHA GBV_ILN_170 GBV_ILN_2006 GBV_ILN_4112 GBV_ILN_4219 GBV_ILN_4256 GBV_ILN_4305 GBV_ILN_4306 WA 15000 44.64 AVZ 44.40 AVZ 33.30 AVZ AR 183 2015 1 94-104
allfieldsGer	10.1667/RR13781.1 doi PQ20160617 (DE-627)OLC1963106644 (DE-599)GBVOLC1963106644 (PRQ)b2298-d437b8fa592b788d6ff132382786d4882562c7e24179cb53605f4ee5d65dbcca0 (KEY)0012922420150000183000100094effectofionizingradiationonmrnalevelsofthednadamag DE-627 ger DE-627 rakwb eng 610 530 DNB WA 15000 AVZ rvk 44.64 bkl 44.40 bkl 33.30 bkl Zhenya Zhang verfasserin aut The Effect of Ionizing Radiation on mRNA Levels of the DNA Damage Response Genes Rad9, Rad1 and Hus1 in Various Mouse Tissues 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Rad9, Rad1 and Hus1 are essential genes conserved from yeast to humans. They form a heterotrimer complex (9-1-1 complex) that participates in the cell cycle checkpoint activation and DNA damage repair in eukaryotic cells. Rad9, Rad1 and Hus1 deficient cells are hypersensitive to ionizing radiation and mouse cells deleted for anyone of the three genes are highly sensitive to the killing by gamma rays. We propose that ionizing radiation-induced transcription of these genes is a mechanism by which cells respond to radiation-induced damage. In this study we used quantitative real-time RT-PCR(qPCR) to analyze the mRNA levels of Rad9, Rad1 and Hus1 in various tissues isolated from mice that were either mock irradiated or exposed to 10 Gy gamma radiation. Our results indicated that the mRNA levels of Rad9, Rad1 and Hus1 genes were very different among these tissues, and we found high natural levels of mRNA in the spleen, lung, ovary and testis of mice before exposure to radiation. The mRNA levels of the three ge... DNA Damage - genetics Gene Expression Regulation - radiation effects RNA, Messenger - metabolism Gamma Rays - adverse effects Exonucleases - genetics RNA, Messenger - genetics Cell Cycle Proteins - genetics Zeyuan Cai oth Kaiming Li oth Yu Fang oth Lili An oth Zhishang Hu oth Shihua Wang oth Haiying Hang oth Enthalten in Radiation research Lawrence, Kan. : Soc., 1954 183(2015), 1, Seite 94-104 (DE-627)129270644 (DE-600)80322-4 (DE-576)01446120X 0033-7587 nnns volume:183 year:2015 number:1 pages:94-104 http://dx.doi.org/10.1667/RR13781.1 Volltext http://www.bioone.org/doi/full/10.1667/RR13781.1 http://www.ncbi.nlm.nih.gov/pubmed/25564717 http://search.proquest.com/docview/1648380067 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-PHA GBV_ILN_170 GBV_ILN_2006 GBV_ILN_4112 GBV_ILN_4219 GBV_ILN_4256 GBV_ILN_4305 GBV_ILN_4306 WA 15000 44.64 AVZ 44.40 AVZ 33.30 AVZ AR 183 2015 1 94-104
allfieldsSound	10.1667/RR13781.1 doi PQ20160617 (DE-627)OLC1963106644 (DE-599)GBVOLC1963106644 (PRQ)b2298-d437b8fa592b788d6ff132382786d4882562c7e24179cb53605f4ee5d65dbcca0 (KEY)0012922420150000183000100094effectofionizingradiationonmrnalevelsofthednadamag DE-627 ger DE-627 rakwb eng 610 530 DNB WA 15000 AVZ rvk 44.64 bkl 44.40 bkl 33.30 bkl Zhenya Zhang verfasserin aut The Effect of Ionizing Radiation on mRNA Levels of the DNA Damage Response Genes Rad9, Rad1 and Hus1 in Various Mouse Tissues 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Rad9, Rad1 and Hus1 are essential genes conserved from yeast to humans. They form a heterotrimer complex (9-1-1 complex) that participates in the cell cycle checkpoint activation and DNA damage repair in eukaryotic cells. Rad9, Rad1 and Hus1 deficient cells are hypersensitive to ionizing radiation and mouse cells deleted for anyone of the three genes are highly sensitive to the killing by gamma rays. We propose that ionizing radiation-induced transcription of these genes is a mechanism by which cells respond to radiation-induced damage. In this study we used quantitative real-time RT-PCR(qPCR) to analyze the mRNA levels of Rad9, Rad1 and Hus1 in various tissues isolated from mice that were either mock irradiated or exposed to 10 Gy gamma radiation. Our results indicated that the mRNA levels of Rad9, Rad1 and Hus1 genes were very different among these tissues, and we found high natural levels of mRNA in the spleen, lung, ovary and testis of mice before exposure to radiation. The mRNA levels of the three ge... DNA Damage - genetics Gene Expression Regulation - radiation effects RNA, Messenger - metabolism Gamma Rays - adverse effects Exonucleases - genetics RNA, Messenger - genetics Cell Cycle Proteins - genetics Zeyuan Cai oth Kaiming Li oth Yu Fang oth Lili An oth Zhishang Hu oth Shihua Wang oth Haiying Hang oth Enthalten in Radiation research Lawrence, Kan. : Soc., 1954 183(2015), 1, Seite 94-104 (DE-627)129270644 (DE-600)80322-4 (DE-576)01446120X 0033-7587 nnns volume:183 year:2015 number:1 pages:94-104 http://dx.doi.org/10.1667/RR13781.1 Volltext http://www.bioone.org/doi/full/10.1667/RR13781.1 http://www.ncbi.nlm.nih.gov/pubmed/25564717 http://search.proquest.com/docview/1648380067 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-PHA GBV_ILN_170 GBV_ILN_2006 GBV_ILN_4112 GBV_ILN_4219 GBV_ILN_4256 GBV_ILN_4305 GBV_ILN_4306 WA 15000 44.64 AVZ 44.40 AVZ 33.30 AVZ AR 183 2015 1 94-104
language	English
source	Enthalten in Radiation research 183(2015), 1, Seite 94-104 volume:183 year:2015 number:1 pages:94-104
sourceStr	Enthalten in Radiation research 183(2015), 1, Seite 94-104 volume:183 year:2015 number:1 pages:94-104
format_phy_str_mv	Article
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topic_facet	DNA Damage - genetics Gene Expression Regulation - radiation effects RNA, Messenger - metabolism Gamma Rays - adverse effects Exonucleases - genetics RNA, Messenger - genetics Cell Cycle Proteins - genetics
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author	Zhenya Zhang
spellingShingle	Zhenya Zhang ddc 610 rvk WA 15000 bkl 44.64 bkl 44.40 bkl 33.30 misc DNA Damage - genetics misc Gene Expression Regulation - radiation effects misc RNA, Messenger - metabolism misc Gamma Rays - adverse effects misc Exonucleases - genetics misc RNA, Messenger - genetics misc Cell Cycle Proteins - genetics The Effect of Ionizing Radiation on mRNA Levels of the DNA Damage Response Genes Rad9, Rad1 and Hus1 in Various Mouse Tissues
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topic_title	610 530 DNB WA 15000 AVZ rvk 44.64 bkl 44.40 bkl 33.30 bkl The Effect of Ionizing Radiation on mRNA Levels of the DNA Damage Response Genes Rad9, Rad1 and Hus1 in Various Mouse Tissues DNA Damage - genetics Gene Expression Regulation - radiation effects RNA, Messenger - metabolism Gamma Rays - adverse effects Exonucleases - genetics RNA, Messenger - genetics Cell Cycle Proteins - genetics
topic	ddc 610 rvk WA 15000 bkl 44.64 bkl 44.40 bkl 33.30 misc DNA Damage - genetics misc Gene Expression Regulation - radiation effects misc RNA, Messenger - metabolism misc Gamma Rays - adverse effects misc Exonucleases - genetics misc RNA, Messenger - genetics misc Cell Cycle Proteins - genetics
topic_unstemmed	ddc 610 rvk WA 15000 bkl 44.64 bkl 44.40 bkl 33.30 misc DNA Damage - genetics misc Gene Expression Regulation - radiation effects misc RNA, Messenger - metabolism misc Gamma Rays - adverse effects misc Exonucleases - genetics misc RNA, Messenger - genetics misc Cell Cycle Proteins - genetics
topic_browse	ddc 610 rvk WA 15000 bkl 44.64 bkl 44.40 bkl 33.30 misc DNA Damage - genetics misc Gene Expression Regulation - radiation effects misc RNA, Messenger - metabolism misc Gamma Rays - adverse effects misc Exonucleases - genetics misc RNA, Messenger - genetics misc Cell Cycle Proteins - genetics
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title	The Effect of Ionizing Radiation on mRNA Levels of the DNA Damage Response Genes Rad9, Rad1 and Hus1 in Various Mouse Tissues
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title_full	The Effect of Ionizing Radiation on mRNA Levels of the DNA Damage Response Genes Rad9, Rad1 and Hus1 in Various Mouse Tissues
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title_sort	effect of ionizing radiation on mrna levels of the dna damage response genes rad9, rad1 and hus1 in various mouse tissues
title_auth	The Effect of Ionizing Radiation on mRNA Levels of the DNA Damage Response Genes Rad9, Rad1 and Hus1 in Various Mouse Tissues
abstract	Rad9, Rad1 and Hus1 are essential genes conserved from yeast to humans. They form a heterotrimer complex (9-1-1 complex) that participates in the cell cycle checkpoint activation and DNA damage repair in eukaryotic cells. Rad9, Rad1 and Hus1 deficient cells are hypersensitive to ionizing radiation and mouse cells deleted for anyone of the three genes are highly sensitive to the killing by gamma rays. We propose that ionizing radiation-induced transcription of these genes is a mechanism by which cells respond to radiation-induced damage. In this study we used quantitative real-time RT-PCR(qPCR) to analyze the mRNA levels of Rad9, Rad1 and Hus1 in various tissues isolated from mice that were either mock irradiated or exposed to 10 Gy gamma radiation. Our results indicated that the mRNA levels of Rad9, Rad1 and Hus1 genes were very different among these tissues, and we found high natural levels of mRNA in the spleen, lung, ovary and testis of mice before exposure to radiation. The mRNA levels of the three ge...
abstractGer	Rad9, Rad1 and Hus1 are essential genes conserved from yeast to humans. They form a heterotrimer complex (9-1-1 complex) that participates in the cell cycle checkpoint activation and DNA damage repair in eukaryotic cells. Rad9, Rad1 and Hus1 deficient cells are hypersensitive to ionizing radiation and mouse cells deleted for anyone of the three genes are highly sensitive to the killing by gamma rays. We propose that ionizing radiation-induced transcription of these genes is a mechanism by which cells respond to radiation-induced damage. In this study we used quantitative real-time RT-PCR(qPCR) to analyze the mRNA levels of Rad9, Rad1 and Hus1 in various tissues isolated from mice that were either mock irradiated or exposed to 10 Gy gamma radiation. Our results indicated that the mRNA levels of Rad9, Rad1 and Hus1 genes were very different among these tissues, and we found high natural levels of mRNA in the spleen, lung, ovary and testis of mice before exposure to radiation. The mRNA levels of the three ge...
abstract_unstemmed	Rad9, Rad1 and Hus1 are essential genes conserved from yeast to humans. They form a heterotrimer complex (9-1-1 complex) that participates in the cell cycle checkpoint activation and DNA damage repair in eukaryotic cells. Rad9, Rad1 and Hus1 deficient cells are hypersensitive to ionizing radiation and mouse cells deleted for anyone of the three genes are highly sensitive to the killing by gamma rays. We propose that ionizing radiation-induced transcription of these genes is a mechanism by which cells respond to radiation-induced damage. In this study we used quantitative real-time RT-PCR(qPCR) to analyze the mRNA levels of Rad9, Rad1 and Hus1 in various tissues isolated from mice that were either mock irradiated or exposed to 10 Gy gamma radiation. Our results indicated that the mRNA levels of Rad9, Rad1 and Hus1 genes were very different among these tissues, and we found high natural levels of mRNA in the spleen, lung, ovary and testis of mice before exposure to radiation. The mRNA levels of the three ge...
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container_issue	1
title_short	The Effect of Ionizing Radiation on mRNA Levels of the DNA Damage Response Genes Rad9, Rad1 and Hus1 in Various Mouse Tissues
url	http://dx.doi.org/10.1667/RR13781.1 http://www.bioone.org/doi/full/10.1667/RR13781.1 http://www.ncbi.nlm.nih.gov/pubmed/25564717 http://search.proquest.com/docview/1648380067
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author2	Zeyuan Cai Kaiming Li Yu Fang Lili An Zhishang Hu Shihua Wang Haiying Hang
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