Effects of Local Heart Irradiation in a Glutathione S-Transferase Alpha 4-Null Mouse Model

Glutathione S-transferase alpha 4 (GSTA4-4) is one of the enzymes responsible for the removal of 4-hydroxynonenal (4-HNE), an electrophilic product of lipid peroxidation in cellular membranes during oxidative stress. 4-HNE is a direct activator of nuclear factor (erythroid-derived 2)-like 2 (Nrf2),...
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Gespeichert in:

Autor*in:	Marjan Boerma [verfasserIn] Preeti Singh Vijayalakshmi Sridharan Preeti Tripathi Sunil Sharma Sharda P. Singh

Format:	Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Heart - radiation effects Mitochondria - metabolism Oxidative Stress - genetics Heart - physiology Oxygen - metabolism Oxidative Stress - radiation effects Fibroblasts - radiation effects Fibroblasts - cytology Troponin I - blood Glutathione Transferase - genetics Glutathione Transferase - deficiency Embryo, Mammalian - cytology Mitochondria - radiation effects Cell Survival - radiation effects NF-E2-Related Factor 2 - metabolism

Systematik:	WA 15000

Übergeordnetes Werk:	Enthalten in: Radiation research - Lawrence, Kan. : Soc., 1954, 183(2015), 6, Seite 610-619
Übergeordnetes Werk:	volume:183 ; year:2015 ; number:6 ; pages:610-619

Links:	Volltext Link aufrufen Link aufrufen Link aufrufen

DOI / URN:	10.1667/RR13979.1

Katalog-ID:	OLC1963106814

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520			\|a Glutathione S-transferase alpha 4 (GSTA4-4) is one of the enzymes responsible for the removal of 4-hydroxynonenal (4-HNE), an electrophilic product of lipid peroxidation in cellular membranes during oxidative stress. 4-HNE is a direct activator of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a transcription factor with many target genes encoding antioxidant and anti-electrophile enzymes. We have previously shown that Gsta4-null mice on a 129/Sv background exhibited increased activity of Nrf2 in the heart. Here we examined the sensitivity of this Gsta4-null mouse model towards cardiac function and structure loss due to local heart irradiation. Male Gsta4-null and wild-type mice were exposed to a single X-ray dose of 18 Gy to the heart. Six months after irradiation, immunohistochemical staining for respiratory complexes 2 and 5 indicated that radiation exposure had caused most pronounced alterations in mitochondrial morphology in Gsta4-null mice. On the other hand, wild-type mice showed a decline in ...
650		4	\|a Heart - radiation effects
650		4	\|a Mitochondria - metabolism
650		4	\|a Oxidative Stress - genetics
650		4	\|a Heart - physiology
650		4	\|a Oxygen - metabolism
650		4	\|a Oxidative Stress - radiation effects
650		4	\|a Fibroblasts - radiation effects
650		4	\|a Fibroblasts - cytology
650		4	\|a Troponin I - blood
650		4	\|a Glutathione Transferase - genetics
650		4	\|a Glutathione Transferase - deficiency
650		4	\|a Embryo, Mammalian - cytology
650		4	\|a Mitochondria - radiation effects
650		4	\|a Cell Survival - radiation effects
650		4	\|a NF-E2-Related Factor 2 - metabolism
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700	0		\|a Vijayalakshmi Sridharan \|4 oth
700	0		\|a Preeti Tripathi \|4 oth
700	0		\|a Sunil Sharma \|4 oth
700	0		\|a Sharda P. Singh \|4 oth
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allfields	10.1667/RR13979.1 doi PQ20160617 (DE-627)OLC1963106814 (DE-599)GBVOLC1963106814 (PRQ)b2003-1f50df04ae366cdcacf63890b55998b221be8c2ee1cb7729cd31eb33401ff8600 (KEY)0012922420150000183000600610effectsoflocalheartirradiationinaglutathionestrans DE-627 ger DE-627 rakwb eng 610 530 DNB WA 15000 AVZ rvk 44.64 bkl 44.40 bkl 33.30 bkl Marjan Boerma verfasserin aut Effects of Local Heart Irradiation in a Glutathione S-Transferase Alpha 4-Null Mouse Model 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Glutathione S-transferase alpha 4 (GSTA4-4) is one of the enzymes responsible for the removal of 4-hydroxynonenal (4-HNE), an electrophilic product of lipid peroxidation in cellular membranes during oxidative stress. 4-HNE is a direct activator of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a transcription factor with many target genes encoding antioxidant and anti-electrophile enzymes. We have previously shown that Gsta4-null mice on a 129/Sv background exhibited increased activity of Nrf2 in the heart. Here we examined the sensitivity of this Gsta4-null mouse model towards cardiac function and structure loss due to local heart irradiation. Male Gsta4-null and wild-type mice were exposed to a single X-ray dose of 18 Gy to the heart. Six months after irradiation, immunohistochemical staining for respiratory complexes 2 and 5 indicated that radiation exposure had caused most pronounced alterations in mitochondrial morphology in Gsta4-null mice. On the other hand, wild-type mice showed a decline in ... Heart - radiation effects Mitochondria - metabolism Oxidative Stress - genetics Heart - physiology Oxygen - metabolism Oxidative Stress - radiation effects Fibroblasts - radiation effects Fibroblasts - cytology Troponin I - blood Glutathione Transferase - genetics Glutathione Transferase - deficiency Embryo, Mammalian - cytology Mitochondria - radiation effects Cell Survival - radiation effects NF-E2-Related Factor 2 - metabolism Preeti Singh oth Vijayalakshmi Sridharan oth Preeti Tripathi oth Sunil Sharma oth Sharda P. Singh oth Enthalten in Radiation research Lawrence, Kan. : Soc., 1954 183(2015), 6, Seite 610-619 (DE-627)129270644 (DE-600)80322-4 (DE-576)01446120X 0033-7587 nnns volume:183 year:2015 number:6 pages:610-619 http://dx.doi.org/10.1667/RR13979.1 Volltext http://www.bioone.org/doi/full/10.1667/RR13979.1 http://www.ncbi.nlm.nih.gov/pubmed/26010708 http://search.proquest.com/docview/1691291542 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-PHA GBV_ILN_170 GBV_ILN_2006 GBV_ILN_4112 GBV_ILN_4219 GBV_ILN_4256 GBV_ILN_4305 GBV_ILN_4306 WA 15000 44.64 AVZ 44.40 AVZ 33.30 AVZ AR 183 2015 6 610-619
spelling	10.1667/RR13979.1 doi PQ20160617 (DE-627)OLC1963106814 (DE-599)GBVOLC1963106814 (PRQ)b2003-1f50df04ae366cdcacf63890b55998b221be8c2ee1cb7729cd31eb33401ff8600 (KEY)0012922420150000183000600610effectsoflocalheartirradiationinaglutathionestrans DE-627 ger DE-627 rakwb eng 610 530 DNB WA 15000 AVZ rvk 44.64 bkl 44.40 bkl 33.30 bkl Marjan Boerma verfasserin aut Effects of Local Heart Irradiation in a Glutathione S-Transferase Alpha 4-Null Mouse Model 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Glutathione S-transferase alpha 4 (GSTA4-4) is one of the enzymes responsible for the removal of 4-hydroxynonenal (4-HNE), an electrophilic product of lipid peroxidation in cellular membranes during oxidative stress. 4-HNE is a direct activator of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a transcription factor with many target genes encoding antioxidant and anti-electrophile enzymes. We have previously shown that Gsta4-null mice on a 129/Sv background exhibited increased activity of Nrf2 in the heart. Here we examined the sensitivity of this Gsta4-null mouse model towards cardiac function and structure loss due to local heart irradiation. Male Gsta4-null and wild-type mice were exposed to a single X-ray dose of 18 Gy to the heart. Six months after irradiation, immunohistochemical staining for respiratory complexes 2 and 5 indicated that radiation exposure had caused most pronounced alterations in mitochondrial morphology in Gsta4-null mice. On the other hand, wild-type mice showed a decline in ... Heart - radiation effects Mitochondria - metabolism Oxidative Stress - genetics Heart - physiology Oxygen - metabolism Oxidative Stress - radiation effects Fibroblasts - radiation effects Fibroblasts - cytology Troponin I - blood Glutathione Transferase - genetics Glutathione Transferase - deficiency Embryo, Mammalian - cytology Mitochondria - radiation effects Cell Survival - radiation effects NF-E2-Related Factor 2 - metabolism Preeti Singh oth Vijayalakshmi Sridharan oth Preeti Tripathi oth Sunil Sharma oth Sharda P. Singh oth Enthalten in Radiation research Lawrence, Kan. : Soc., 1954 183(2015), 6, Seite 610-619 (DE-627)129270644 (DE-600)80322-4 (DE-576)01446120X 0033-7587 nnns volume:183 year:2015 number:6 pages:610-619 http://dx.doi.org/10.1667/RR13979.1 Volltext http://www.bioone.org/doi/full/10.1667/RR13979.1 http://www.ncbi.nlm.nih.gov/pubmed/26010708 http://search.proquest.com/docview/1691291542 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-PHA GBV_ILN_170 GBV_ILN_2006 GBV_ILN_4112 GBV_ILN_4219 GBV_ILN_4256 GBV_ILN_4305 GBV_ILN_4306 WA 15000 44.64 AVZ 44.40 AVZ 33.30 AVZ AR 183 2015 6 610-619
allfields_unstemmed	10.1667/RR13979.1 doi PQ20160617 (DE-627)OLC1963106814 (DE-599)GBVOLC1963106814 (PRQ)b2003-1f50df04ae366cdcacf63890b55998b221be8c2ee1cb7729cd31eb33401ff8600 (KEY)0012922420150000183000600610effectsoflocalheartirradiationinaglutathionestrans DE-627 ger DE-627 rakwb eng 610 530 DNB WA 15000 AVZ rvk 44.64 bkl 44.40 bkl 33.30 bkl Marjan Boerma verfasserin aut Effects of Local Heart Irradiation in a Glutathione S-Transferase Alpha 4-Null Mouse Model 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Glutathione S-transferase alpha 4 (GSTA4-4) is one of the enzymes responsible for the removal of 4-hydroxynonenal (4-HNE), an electrophilic product of lipid peroxidation in cellular membranes during oxidative stress. 4-HNE is a direct activator of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a transcription factor with many target genes encoding antioxidant and anti-electrophile enzymes. We have previously shown that Gsta4-null mice on a 129/Sv background exhibited increased activity of Nrf2 in the heart. Here we examined the sensitivity of this Gsta4-null mouse model towards cardiac function and structure loss due to local heart irradiation. Male Gsta4-null and wild-type mice were exposed to a single X-ray dose of 18 Gy to the heart. Six months after irradiation, immunohistochemical staining for respiratory complexes 2 and 5 indicated that radiation exposure had caused most pronounced alterations in mitochondrial morphology in Gsta4-null mice. On the other hand, wild-type mice showed a decline in ... Heart - radiation effects Mitochondria - metabolism Oxidative Stress - genetics Heart - physiology Oxygen - metabolism Oxidative Stress - radiation effects Fibroblasts - radiation effects Fibroblasts - cytology Troponin I - blood Glutathione Transferase - genetics Glutathione Transferase - deficiency Embryo, Mammalian - cytology Mitochondria - radiation effects Cell Survival - radiation effects NF-E2-Related Factor 2 - metabolism Preeti Singh oth Vijayalakshmi Sridharan oth Preeti Tripathi oth Sunil Sharma oth Sharda P. Singh oth Enthalten in Radiation research Lawrence, Kan. : Soc., 1954 183(2015), 6, Seite 610-619 (DE-627)129270644 (DE-600)80322-4 (DE-576)01446120X 0033-7587 nnns volume:183 year:2015 number:6 pages:610-619 http://dx.doi.org/10.1667/RR13979.1 Volltext http://www.bioone.org/doi/full/10.1667/RR13979.1 http://www.ncbi.nlm.nih.gov/pubmed/26010708 http://search.proquest.com/docview/1691291542 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-PHA GBV_ILN_170 GBV_ILN_2006 GBV_ILN_4112 GBV_ILN_4219 GBV_ILN_4256 GBV_ILN_4305 GBV_ILN_4306 WA 15000 44.64 AVZ 44.40 AVZ 33.30 AVZ AR 183 2015 6 610-619
allfieldsGer	10.1667/RR13979.1 doi PQ20160617 (DE-627)OLC1963106814 (DE-599)GBVOLC1963106814 (PRQ)b2003-1f50df04ae366cdcacf63890b55998b221be8c2ee1cb7729cd31eb33401ff8600 (KEY)0012922420150000183000600610effectsoflocalheartirradiationinaglutathionestrans DE-627 ger DE-627 rakwb eng 610 530 DNB WA 15000 AVZ rvk 44.64 bkl 44.40 bkl 33.30 bkl Marjan Boerma verfasserin aut Effects of Local Heart Irradiation in a Glutathione S-Transferase Alpha 4-Null Mouse Model 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Glutathione S-transferase alpha 4 (GSTA4-4) is one of the enzymes responsible for the removal of 4-hydroxynonenal (4-HNE), an electrophilic product of lipid peroxidation in cellular membranes during oxidative stress. 4-HNE is a direct activator of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a transcription factor with many target genes encoding antioxidant and anti-electrophile enzymes. We have previously shown that Gsta4-null mice on a 129/Sv background exhibited increased activity of Nrf2 in the heart. Here we examined the sensitivity of this Gsta4-null mouse model towards cardiac function and structure loss due to local heart irradiation. Male Gsta4-null and wild-type mice were exposed to a single X-ray dose of 18 Gy to the heart. Six months after irradiation, immunohistochemical staining for respiratory complexes 2 and 5 indicated that radiation exposure had caused most pronounced alterations in mitochondrial morphology in Gsta4-null mice. On the other hand, wild-type mice showed a decline in ... Heart - radiation effects Mitochondria - metabolism Oxidative Stress - genetics Heart - physiology Oxygen - metabolism Oxidative Stress - radiation effects Fibroblasts - radiation effects Fibroblasts - cytology Troponin I - blood Glutathione Transferase - genetics Glutathione Transferase - deficiency Embryo, Mammalian - cytology Mitochondria - radiation effects Cell Survival - radiation effects NF-E2-Related Factor 2 - metabolism Preeti Singh oth Vijayalakshmi Sridharan oth Preeti Tripathi oth Sunil Sharma oth Sharda P. Singh oth Enthalten in Radiation research Lawrence, Kan. : Soc., 1954 183(2015), 6, Seite 610-619 (DE-627)129270644 (DE-600)80322-4 (DE-576)01446120X 0033-7587 nnns volume:183 year:2015 number:6 pages:610-619 http://dx.doi.org/10.1667/RR13979.1 Volltext http://www.bioone.org/doi/full/10.1667/RR13979.1 http://www.ncbi.nlm.nih.gov/pubmed/26010708 http://search.proquest.com/docview/1691291542 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-PHA GBV_ILN_170 GBV_ILN_2006 GBV_ILN_4112 GBV_ILN_4219 GBV_ILN_4256 GBV_ILN_4305 GBV_ILN_4306 WA 15000 44.64 AVZ 44.40 AVZ 33.30 AVZ AR 183 2015 6 610-619
allfieldsSound	10.1667/RR13979.1 doi PQ20160617 (DE-627)OLC1963106814 (DE-599)GBVOLC1963106814 (PRQ)b2003-1f50df04ae366cdcacf63890b55998b221be8c2ee1cb7729cd31eb33401ff8600 (KEY)0012922420150000183000600610effectsoflocalheartirradiationinaglutathionestrans DE-627 ger DE-627 rakwb eng 610 530 DNB WA 15000 AVZ rvk 44.64 bkl 44.40 bkl 33.30 bkl Marjan Boerma verfasserin aut Effects of Local Heart Irradiation in a Glutathione S-Transferase Alpha 4-Null Mouse Model 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Glutathione S-transferase alpha 4 (GSTA4-4) is one of the enzymes responsible for the removal of 4-hydroxynonenal (4-HNE), an electrophilic product of lipid peroxidation in cellular membranes during oxidative stress. 4-HNE is a direct activator of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a transcription factor with many target genes encoding antioxidant and anti-electrophile enzymes. We have previously shown that Gsta4-null mice on a 129/Sv background exhibited increased activity of Nrf2 in the heart. Here we examined the sensitivity of this Gsta4-null mouse model towards cardiac function and structure loss due to local heart irradiation. Male Gsta4-null and wild-type mice were exposed to a single X-ray dose of 18 Gy to the heart. Six months after irradiation, immunohistochemical staining for respiratory complexes 2 and 5 indicated that radiation exposure had caused most pronounced alterations in mitochondrial morphology in Gsta4-null mice. On the other hand, wild-type mice showed a decline in ... Heart - radiation effects Mitochondria - metabolism Oxidative Stress - genetics Heart - physiology Oxygen - metabolism Oxidative Stress - radiation effects Fibroblasts - radiation effects Fibroblasts - cytology Troponin I - blood Glutathione Transferase - genetics Glutathione Transferase - deficiency Embryo, Mammalian - cytology Mitochondria - radiation effects Cell Survival - radiation effects NF-E2-Related Factor 2 - metabolism Preeti Singh oth Vijayalakshmi Sridharan oth Preeti Tripathi oth Sunil Sharma oth Sharda P. Singh oth Enthalten in Radiation research Lawrence, Kan. : Soc., 1954 183(2015), 6, Seite 610-619 (DE-627)129270644 (DE-600)80322-4 (DE-576)01446120X 0033-7587 nnns volume:183 year:2015 number:6 pages:610-619 http://dx.doi.org/10.1667/RR13979.1 Volltext http://www.bioone.org/doi/full/10.1667/RR13979.1 http://www.ncbi.nlm.nih.gov/pubmed/26010708 http://search.proquest.com/docview/1691291542 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-PHA GBV_ILN_170 GBV_ILN_2006 GBV_ILN_4112 GBV_ILN_4219 GBV_ILN_4256 GBV_ILN_4305 GBV_ILN_4306 WA 15000 44.64 AVZ 44.40 AVZ 33.30 AVZ AR 183 2015 6 610-619
language	English
source	Enthalten in Radiation research 183(2015), 6, Seite 610-619 volume:183 year:2015 number:6 pages:610-619
sourceStr	Enthalten in Radiation research 183(2015), 6, Seite 610-619 volume:183 year:2015 number:6 pages:610-619
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institution	findex.gbv.de
topic_facet	Heart - radiation effects Mitochondria - metabolism Oxidative Stress - genetics Heart - physiology Oxygen - metabolism Oxidative Stress - radiation effects Fibroblasts - radiation effects Fibroblasts - cytology Troponin I - blood Glutathione Transferase - genetics Glutathione Transferase - deficiency Embryo, Mammalian - cytology Mitochondria - radiation effects Cell Survival - radiation effects NF-E2-Related Factor 2 - metabolism
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container_title	Radiation research
authorswithroles_txt_mv	Marjan Boerma @@aut@@ Preeti Singh @@oth@@ Vijayalakshmi Sridharan @@oth@@ Preeti Tripathi @@oth@@ Sunil Sharma @@oth@@ Sharda P. Singh @@oth@@
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author	Marjan Boerma
spellingShingle	Marjan Boerma ddc 610 rvk WA 15000 bkl 44.64 bkl 44.40 bkl 33.30 misc Heart - radiation effects misc Mitochondria - metabolism misc Oxidative Stress - genetics misc Heart - physiology misc Oxygen - metabolism misc Oxidative Stress - radiation effects misc Fibroblasts - radiation effects misc Fibroblasts - cytology misc Troponin I - blood misc Glutathione Transferase - genetics misc Glutathione Transferase - deficiency misc Embryo, Mammalian - cytology misc Mitochondria - radiation effects misc Cell Survival - radiation effects misc NF-E2-Related Factor 2 - metabolism Effects of Local Heart Irradiation in a Glutathione S-Transferase Alpha 4-Null Mouse Model
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topic_title	610 530 DNB WA 15000 AVZ rvk 44.64 bkl 44.40 bkl 33.30 bkl Effects of Local Heart Irradiation in a Glutathione S-Transferase Alpha 4-Null Mouse Model Heart - radiation effects Mitochondria - metabolism Oxidative Stress - genetics Heart - physiology Oxygen - metabolism Oxidative Stress - radiation effects Fibroblasts - radiation effects Fibroblasts - cytology Troponin I - blood Glutathione Transferase - genetics Glutathione Transferase - deficiency Embryo, Mammalian - cytology Mitochondria - radiation effects Cell Survival - radiation effects NF-E2-Related Factor 2 - metabolism
topic	ddc 610 rvk WA 15000 bkl 44.64 bkl 44.40 bkl 33.30 misc Heart - radiation effects misc Mitochondria - metabolism misc Oxidative Stress - genetics misc Heart - physiology misc Oxygen - metabolism misc Oxidative Stress - radiation effects misc Fibroblasts - radiation effects misc Fibroblasts - cytology misc Troponin I - blood misc Glutathione Transferase - genetics misc Glutathione Transferase - deficiency misc Embryo, Mammalian - cytology misc Mitochondria - radiation effects misc Cell Survival - radiation effects misc NF-E2-Related Factor 2 - metabolism
topic_unstemmed	ddc 610 rvk WA 15000 bkl 44.64 bkl 44.40 bkl 33.30 misc Heart - radiation effects misc Mitochondria - metabolism misc Oxidative Stress - genetics misc Heart - physiology misc Oxygen - metabolism misc Oxidative Stress - radiation effects misc Fibroblasts - radiation effects misc Fibroblasts - cytology misc Troponin I - blood misc Glutathione Transferase - genetics misc Glutathione Transferase - deficiency misc Embryo, Mammalian - cytology misc Mitochondria - radiation effects misc Cell Survival - radiation effects misc NF-E2-Related Factor 2 - metabolism
topic_browse	ddc 610 rvk WA 15000 bkl 44.64 bkl 44.40 bkl 33.30 misc Heart - radiation effects misc Mitochondria - metabolism misc Oxidative Stress - genetics misc Heart - physiology misc Oxygen - metabolism misc Oxidative Stress - radiation effects misc Fibroblasts - radiation effects misc Fibroblasts - cytology misc Troponin I - blood misc Glutathione Transferase - genetics misc Glutathione Transferase - deficiency misc Embryo, Mammalian - cytology misc Mitochondria - radiation effects misc Cell Survival - radiation effects misc NF-E2-Related Factor 2 - metabolism
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title	Effects of Local Heart Irradiation in a Glutathione S-Transferase Alpha 4-Null Mouse Model
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title_full	Effects of Local Heart Irradiation in a Glutathione S-Transferase Alpha 4-Null Mouse Model
author_sort	Marjan Boerma
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title_sort	effects of local heart irradiation in a glutathione s-transferase alpha 4-null mouse model
title_auth	Effects of Local Heart Irradiation in a Glutathione S-Transferase Alpha 4-Null Mouse Model
abstract	Glutathione S-transferase alpha 4 (GSTA4-4) is one of the enzymes responsible for the removal of 4-hydroxynonenal (4-HNE), an electrophilic product of lipid peroxidation in cellular membranes during oxidative stress. 4-HNE is a direct activator of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a transcription factor with many target genes encoding antioxidant and anti-electrophile enzymes. We have previously shown that Gsta4-null mice on a 129/Sv background exhibited increased activity of Nrf2 in the heart. Here we examined the sensitivity of this Gsta4-null mouse model towards cardiac function and structure loss due to local heart irradiation. Male Gsta4-null and wild-type mice were exposed to a single X-ray dose of 18 Gy to the heart. Six months after irradiation, immunohistochemical staining for respiratory complexes 2 and 5 indicated that radiation exposure had caused most pronounced alterations in mitochondrial morphology in Gsta4-null mice. On the other hand, wild-type mice showed a decline in ...
abstractGer	Glutathione S-transferase alpha 4 (GSTA4-4) is one of the enzymes responsible for the removal of 4-hydroxynonenal (4-HNE), an electrophilic product of lipid peroxidation in cellular membranes during oxidative stress. 4-HNE is a direct activator of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a transcription factor with many target genes encoding antioxidant and anti-electrophile enzymes. We have previously shown that Gsta4-null mice on a 129/Sv background exhibited increased activity of Nrf2 in the heart. Here we examined the sensitivity of this Gsta4-null mouse model towards cardiac function and structure loss due to local heart irradiation. Male Gsta4-null and wild-type mice were exposed to a single X-ray dose of 18 Gy to the heart. Six months after irradiation, immunohistochemical staining for respiratory complexes 2 and 5 indicated that radiation exposure had caused most pronounced alterations in mitochondrial morphology in Gsta4-null mice. On the other hand, wild-type mice showed a decline in ...
abstract_unstemmed	Glutathione S-transferase alpha 4 (GSTA4-4) is one of the enzymes responsible for the removal of 4-hydroxynonenal (4-HNE), an electrophilic product of lipid peroxidation in cellular membranes during oxidative stress. 4-HNE is a direct activator of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), a transcription factor with many target genes encoding antioxidant and anti-electrophile enzymes. We have previously shown that Gsta4-null mice on a 129/Sv background exhibited increased activity of Nrf2 in the heart. Here we examined the sensitivity of this Gsta4-null mouse model towards cardiac function and structure loss due to local heart irradiation. Male Gsta4-null and wild-type mice were exposed to a single X-ray dose of 18 Gy to the heart. Six months after irradiation, immunohistochemical staining for respiratory complexes 2 and 5 indicated that radiation exposure had caused most pronounced alterations in mitochondrial morphology in Gsta4-null mice. On the other hand, wild-type mice showed a decline in ...
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container_issue	6
title_short	Effects of Local Heart Irradiation in a Glutathione S-Transferase Alpha 4-Null Mouse Model
url	http://dx.doi.org/10.1667/RR13979.1 http://www.bioone.org/doi/full/10.1667/RR13979.1 http://www.ncbi.nlm.nih.gov/pubmed/26010708 http://search.proquest.com/docview/1691291542
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up_date	2024-07-04T04:58:51.585Z
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We have previously shown that Gsta4-null mice on a 129/Sv background exhibited increased activity of Nrf2 in the heart. Here we examined the sensitivity of this Gsta4-null mouse model towards cardiac function and structure loss due to local heart irradiation. Male Gsta4-null and wild-type mice were exposed to a single X-ray dose of 18 Gy to the heart. Six months after irradiation, immunohistochemical staining for respiratory complexes 2 and 5 indicated that radiation exposure had caused most pronounced alterations in mitochondrial morphology in Gsta4-null mice. 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Effects of Local Heart Irradiation in a Glutathione S-Transferase Alpha 4-Null Mouse Model

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