sup 28^Silicon Irradiation Impairs Contextual Fear Memory in B6D2F1 Mice
The space radiation environment consists of multiple species of charged particles, including ^sup 28^Si, ^sup 48^Ti and protons that may impact cognition, but their damaging effects have been poorly defined. In mouse studies, C57Bl6/J homozygous wild-type mice and genetic mutant mice on a C57Bl6/J b...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Jacob Raber [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Systematik: |
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| Übergeordnetes Werk: |
Enthalten in: Radiation research - Lawrence, Kan. : Soc., 1954, 183(2015), 6, Seite 708 |
|---|---|
| Übergeordnetes Werk: |
volume:183 ; year:2015 ; number:6 ; pages:708 |
| Links: |
|---|
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OLC1963107586 |
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| 520 | |a The space radiation environment consists of multiple species of charged particles, including ^sup 28^Si, ^sup 48^Ti and protons that may impact cognition, but their damaging effects have been poorly defined. In mouse studies, C57Bl6/J homozygous wild-type mice and genetic mutant mice on a C57Bl6/J background have typically been used for assessing effects of space radiation on cognition. In contrast, little is known about the radiation response of mice on a heterozygous background. Therefore, in the current study we tested the effects of ^sup 28^Si, ^sup 48^Ti and proton radiation on hippocampusdependent contextual fear memory and hippocampus-independent cued fear memory in C57Bl6/J × DBA2/J F1 (B6D2F1) mice three months after irradiation. Contextual fear memory was impaired at a 1.6 Gy dose of ^sup 28^Si radiation, but not cued fear memory. ^sup 48^Ti or proton irradiation did not affect either type of memory. Based on earlier space radiation cognitive data in C57Bl6/J mice, these data highlight the importance of including different genetic backgrounds in studies aimed at assessing cognitive changes after exposure to space radiation. | ||
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sup 28^Silicon Irradiation Impairs Contextual Fear Memory in B6D2F1 Mice |
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sup 28^Silicon Irradiation Impairs Contextual Fear Memory in B6D2F1 Mice |
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sup 28^silicon irradiation impairs contextual fear memory in b6d2f1 mice |
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sup 28^Silicon Irradiation Impairs Contextual Fear Memory in B6D2F1 Mice |
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The space radiation environment consists of multiple species of charged particles, including ^sup 28^Si, ^sup 48^Ti and protons that may impact cognition, but their damaging effects have been poorly defined. In mouse studies, C57Bl6/J homozygous wild-type mice and genetic mutant mice on a C57Bl6/J background have typically been used for assessing effects of space radiation on cognition. In contrast, little is known about the radiation response of mice on a heterozygous background. Therefore, in the current study we tested the effects of ^sup 28^Si, ^sup 48^Ti and proton radiation on hippocampusdependent contextual fear memory and hippocampus-independent cued fear memory in C57Bl6/J × DBA2/J F1 (B6D2F1) mice three months after irradiation. Contextual fear memory was impaired at a 1.6 Gy dose of ^sup 28^Si radiation, but not cued fear memory. ^sup 48^Ti or proton irradiation did not affect either type of memory. Based on earlier space radiation cognitive data in C57Bl6/J mice, these data highlight the importance of including different genetic backgrounds in studies aimed at assessing cognitive changes after exposure to space radiation. |
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The space radiation environment consists of multiple species of charged particles, including ^sup 28^Si, ^sup 48^Ti and protons that may impact cognition, but their damaging effects have been poorly defined. In mouse studies, C57Bl6/J homozygous wild-type mice and genetic mutant mice on a C57Bl6/J background have typically been used for assessing effects of space radiation on cognition. In contrast, little is known about the radiation response of mice on a heterozygous background. Therefore, in the current study we tested the effects of ^sup 28^Si, ^sup 48^Ti and proton radiation on hippocampusdependent contextual fear memory and hippocampus-independent cued fear memory in C57Bl6/J × DBA2/J F1 (B6D2F1) mice three months after irradiation. Contextual fear memory was impaired at a 1.6 Gy dose of ^sup 28^Si radiation, but not cued fear memory. ^sup 48^Ti or proton irradiation did not affect either type of memory. Based on earlier space radiation cognitive data in C57Bl6/J mice, these data highlight the importance of including different genetic backgrounds in studies aimed at assessing cognitive changes after exposure to space radiation. |
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The space radiation environment consists of multiple species of charged particles, including ^sup 28^Si, ^sup 48^Ti and protons that may impact cognition, but their damaging effects have been poorly defined. In mouse studies, C57Bl6/J homozygous wild-type mice and genetic mutant mice on a C57Bl6/J background have typically been used for assessing effects of space radiation on cognition. In contrast, little is known about the radiation response of mice on a heterozygous background. Therefore, in the current study we tested the effects of ^sup 28^Si, ^sup 48^Ti and proton radiation on hippocampusdependent contextual fear memory and hippocampus-independent cued fear memory in C57Bl6/J × DBA2/J F1 (B6D2F1) mice three months after irradiation. Contextual fear memory was impaired at a 1.6 Gy dose of ^sup 28^Si radiation, but not cued fear memory. ^sup 48^Ti or proton irradiation did not affect either type of memory. Based on earlier space radiation cognitive data in C57Bl6/J mice, these data highlight the importance of including different genetic backgrounds in studies aimed at assessing cognitive changes after exposure to space radiation. |
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sup 28^Silicon Irradiation Impairs Contextual Fear Memory in B6D2F1 Mice |
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