Use of (99m)Tc-doxorubicin scintigraphy in females with breast cancer: a pilot study
Doxorubicin (Eurofarma, São Paulo, Brazil) is an antitumour agent widely used in the treatment of breast cancer and can be used for tumour tracking when labelled with a radionuclide. Here, we present the results obtained with technetium-99m ((99m)Tc)-doxorubicin, using the direct method, to evaluate...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Araujo, F I [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
Carcinoma, Ductal, Breast - radionuclide imaging |
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| Systematik: |
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| Übergeordnetes Werk: |
Enthalten in: The British journal of radiology - Oxford : Oxford University Press, 1928, 88(2015), 1052 |
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| Übergeordnetes Werk: |
volume:88 ; year:2015 ; number:1052 |
| Links: |
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| 520 | |a Doxorubicin (Eurofarma, São Paulo, Brazil) is an antitumour agent widely used in the treatment of breast cancer and can be used for tumour tracking when labelled with a radionuclide. Here, we present the results obtained with technetium-99m ((99m)Tc)-doxorubicin, using the direct method, to evaluate its uptake in breast cancer. Four females with confirmed breast carcinoma diagnosis and breast image reporting and data system Category 5 on mammography underwent whole-body and thorax single-photon emission CT/CT imaging 1 and 3 h after (99m)Tc-doxorubicin administration. We observed increased uptake in breast carcinoma lesions and elimination via renal and hepatic pathways. These preliminary results suggest that (99m)Tc-doxorubicin may be a promising radiopharmaceutical for the evaluation of patients with breast cancer. Further studies are ongoing. To our knowledge, this is the first study to evaluate the use of a directly labelled doxorubicin tracer in humans. (99m)Tc-doxorubicin could provide information on the response of tumours to doxorubicin. | ||
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PQ20160617 (DE-627)OLC1964099420 (DE-599)GBVOLC1964099420 (PRQ)pubmed_primary_261112700 (KEY)0026188220150000088105200000useof99mtcdoxorubicinscintigraphyinfemaleswithbrea DE-627 ger DE-627 rakwb eng 610 DNB XA 34700 AVZ rvk 44.64 bkl 44.40 bkl Araujo, F I verfasserin aut Use of (99m)Tc-doxorubicin scintigraphy in females with breast cancer: a pilot study 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Doxorubicin (Eurofarma, São Paulo, Brazil) is an antitumour agent widely used in the treatment of breast cancer and can be used for tumour tracking when labelled with a radionuclide. Here, we present the results obtained with technetium-99m ((99m)Tc)-doxorubicin, using the direct method, to evaluate its uptake in breast cancer. Four females with confirmed breast carcinoma diagnosis and breast image reporting and data system Category 5 on mammography underwent whole-body and thorax single-photon emission CT/CT imaging 1 and 3 h after (99m)Tc-doxorubicin administration. We observed increased uptake in breast carcinoma lesions and elimination via renal and hepatic pathways. These preliminary results suggest that (99m)Tc-doxorubicin may be a promising radiopharmaceutical for the evaluation of patients with breast cancer. Further studies are ongoing. To our knowledge, this is the first study to evaluate the use of a directly labelled doxorubicin tracer in humans. (99m)Tc-doxorubicin could provide information on the response of tumours to doxorubicin. Carcinoma, Ductal, Breast - radionuclide imaging Carcinoma, Lobular - radionuclide imaging Breast Neoplasms - radionuclide imaging Proença, F P P oth Ferreira, C G oth Ventilari, S C oth Rosado de Castro, P H oth Moreira, R D oth Fonseca, L M B oth Souza, S A L oth Gutfilen, B oth Enthalten in The British journal of radiology Oxford : Oxford University Press, 1928 88(2015), 1052 (DE-627)129077976 (DE-600)2982-8 (DE-576)014410524 0007-1285 nnns volume:88 year:2015 number:1052 http://www.ncbi.nlm.nih.gov/pubmed/26111270 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_24 GBV_ILN_74 GBV_ILN_170 GBV_ILN_4012 GBV_ILN_4219 GBV_ILN_4305 XA 34700 44.64 AVZ 44.40 AVZ AR 88 2015 1052 |
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PQ20160617 (DE-627)OLC1964099420 (DE-599)GBVOLC1964099420 (PRQ)pubmed_primary_261112700 (KEY)0026188220150000088105200000useof99mtcdoxorubicinscintigraphyinfemaleswithbrea DE-627 ger DE-627 rakwb eng 610 DNB XA 34700 AVZ rvk 44.64 bkl 44.40 bkl Araujo, F I verfasserin aut Use of (99m)Tc-doxorubicin scintigraphy in females with breast cancer: a pilot study 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Doxorubicin (Eurofarma, São Paulo, Brazil) is an antitumour agent widely used in the treatment of breast cancer and can be used for tumour tracking when labelled with a radionuclide. Here, we present the results obtained with technetium-99m ((99m)Tc)-doxorubicin, using the direct method, to evaluate its uptake in breast cancer. Four females with confirmed breast carcinoma diagnosis and breast image reporting and data system Category 5 on mammography underwent whole-body and thorax single-photon emission CT/CT imaging 1 and 3 h after (99m)Tc-doxorubicin administration. We observed increased uptake in breast carcinoma lesions and elimination via renal and hepatic pathways. These preliminary results suggest that (99m)Tc-doxorubicin may be a promising radiopharmaceutical for the evaluation of patients with breast cancer. Further studies are ongoing. To our knowledge, this is the first study to evaluate the use of a directly labelled doxorubicin tracer in humans. (99m)Tc-doxorubicin could provide information on the response of tumours to doxorubicin. Carcinoma, Ductal, Breast - radionuclide imaging Carcinoma, Lobular - radionuclide imaging Breast Neoplasms - radionuclide imaging Proença, F P P oth Ferreira, C G oth Ventilari, S C oth Rosado de Castro, P H oth Moreira, R D oth Fonseca, L M B oth Souza, S A L oth Gutfilen, B oth Enthalten in The British journal of radiology Oxford : Oxford University Press, 1928 88(2015), 1052 (DE-627)129077976 (DE-600)2982-8 (DE-576)014410524 0007-1285 nnns volume:88 year:2015 number:1052 http://www.ncbi.nlm.nih.gov/pubmed/26111270 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_24 GBV_ILN_74 GBV_ILN_170 GBV_ILN_4012 GBV_ILN_4219 GBV_ILN_4305 XA 34700 44.64 AVZ 44.40 AVZ AR 88 2015 1052 |
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use of (99m)tc-doxorubicin scintigraphy in females with breast cancer: a pilot study |
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Use of (99m)Tc-doxorubicin scintigraphy in females with breast cancer: a pilot study |
| abstract |
Doxorubicin (Eurofarma, São Paulo, Brazil) is an antitumour agent widely used in the treatment of breast cancer and can be used for tumour tracking when labelled with a radionuclide. Here, we present the results obtained with technetium-99m ((99m)Tc)-doxorubicin, using the direct method, to evaluate its uptake in breast cancer. Four females with confirmed breast carcinoma diagnosis and breast image reporting and data system Category 5 on mammography underwent whole-body and thorax single-photon emission CT/CT imaging 1 and 3 h after (99m)Tc-doxorubicin administration. We observed increased uptake in breast carcinoma lesions and elimination via renal and hepatic pathways. These preliminary results suggest that (99m)Tc-doxorubicin may be a promising radiopharmaceutical for the evaluation of patients with breast cancer. Further studies are ongoing. To our knowledge, this is the first study to evaluate the use of a directly labelled doxorubicin tracer in humans. (99m)Tc-doxorubicin could provide information on the response of tumours to doxorubicin. |
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Doxorubicin (Eurofarma, São Paulo, Brazil) is an antitumour agent widely used in the treatment of breast cancer and can be used for tumour tracking when labelled with a radionuclide. Here, we present the results obtained with technetium-99m ((99m)Tc)-doxorubicin, using the direct method, to evaluate its uptake in breast cancer. Four females with confirmed breast carcinoma diagnosis and breast image reporting and data system Category 5 on mammography underwent whole-body and thorax single-photon emission CT/CT imaging 1 and 3 h after (99m)Tc-doxorubicin administration. We observed increased uptake in breast carcinoma lesions and elimination via renal and hepatic pathways. These preliminary results suggest that (99m)Tc-doxorubicin may be a promising radiopharmaceutical for the evaluation of patients with breast cancer. Further studies are ongoing. To our knowledge, this is the first study to evaluate the use of a directly labelled doxorubicin tracer in humans. (99m)Tc-doxorubicin could provide information on the response of tumours to doxorubicin. |
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Doxorubicin (Eurofarma, São Paulo, Brazil) is an antitumour agent widely used in the treatment of breast cancer and can be used for tumour tracking when labelled with a radionuclide. Here, we present the results obtained with technetium-99m ((99m)Tc)-doxorubicin, using the direct method, to evaluate its uptake in breast cancer. Four females with confirmed breast carcinoma diagnosis and breast image reporting and data system Category 5 on mammography underwent whole-body and thorax single-photon emission CT/CT imaging 1 and 3 h after (99m)Tc-doxorubicin administration. We observed increased uptake in breast carcinoma lesions and elimination via renal and hepatic pathways. These preliminary results suggest that (99m)Tc-doxorubicin may be a promising radiopharmaceutical for the evaluation of patients with breast cancer. Further studies are ongoing. To our knowledge, this is the first study to evaluate the use of a directly labelled doxorubicin tracer in humans. (99m)Tc-doxorubicin could provide information on the response of tumours to doxorubicin. |
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Use of (99m)Tc-doxorubicin scintigraphy in females with breast cancer: a pilot study |
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