Autophagy is upregulated in brain tissues of pigeons exposed to avermectin
Avermectin (AVM) is used in agriculture and veterinary medicine for the prevention of parasitic diseases; AVM is the active component of some insecticidal and nematicidal products. Residues of AVM drugs or their metabolites in livestock feces have toxic effects on non-target aquatic and terrestrial...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Qu, Jianping [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Rechteinformationen: |
Nutzungsrecht: Copyright © 2014 Elsevier Inc. All rights reserved. |
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| Schlagwörter: |
TOR Serine-Threonine Kinases - metabolism |
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| Übergeordnetes Werk: |
Enthalten in: Ecotoxicology and environmental safety - Amsterdam : Elsevier, 1977, 113(2015), Seite 159-168 |
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| Übergeordnetes Werk: |
volume:113 ; year:2015 ; pages:159-168 |
| Links: |
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| DOI / URN: |
10.1016/j.ecoenv.2014.12.002 |
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OLC1964314429 |
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| 245 | 1 | 0 | |a Autophagy is upregulated in brain tissues of pigeons exposed to avermectin |
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| 520 | |a Avermectin (AVM) is used in agriculture and veterinary medicine for the prevention of parasitic diseases; AVM is the active component of some insecticidal and nematicidal products. Residues of AVM drugs or their metabolites in livestock feces have toxic effects on non-target aquatic and terrestrial organisms. In this study, changes in the levels of autophagy related genes and ultrastructure in pigeon brain tissues after subchronic exposure to AVM for 30, 60 and 90 d were investigated. The decrease in the mRNA levels of TORC1 and TORC2 and increase in the mRNA levels of LC3, Beclin 1, Dynein, ATG5 and ATG4B and the increase in the protein levels of LC3, Beclin 1 and Dynein in a dose- and time-dependent manner in the pigeon brain were observed. The number of autophagic vacuoles in the cerebrum, cerebellum and optic lobe increased significantly with the concentration of AVM and the exposure time. We found that the changes in the levels of autophagy related genes and the ultrastructure in the cerebrum were more obvious than in the cerebellum and the optic lobe. The results suggest that AVM could induce autophagy in pigeon brain tissues. The information presented in this study is helpful for understanding the mechanism of AVM-induced autophagy in birds. | ||
| 540 | |a Nutzungsrecht: Copyright © 2014 Elsevier Inc. All rights reserved. | ||
| 650 | 4 | |a TOR Serine-Threonine Kinases - metabolism | |
| 650 | 4 | |a Up-Regulation - drug effects | |
| 650 | 4 | |a Ivermectin - toxicity | |
| 650 | 4 | |a RNA, Messenger - metabolism | |
| 650 | 4 | |a Autophagy - drug effects | |
| 650 | 4 | |a Brain - metabolism | |
| 650 | 4 | |a Multiprotein Complexes - metabolism | |
| 650 | 4 | |a Insecticides - toxicity | |
| 650 | 4 | |a Dyneins - metabolism | |
| 650 | 4 | |a Brain - drug effects | |
| 650 | 4 | |a Brain - ultrastructure | |
| 650 | 4 | |a Ivermectin - analogs & derivatives | |
| 700 | 1 | |a Li, Ming |4 oth | |
| 700 | 1 | |a Zhao, Fuqing |4 oth | |
| 700 | 1 | |a Liu, Ci |4 oth | |
| 700 | 1 | |a Zhang, Ziwei |4 oth | |
| 700 | 1 | |a Xu, Shiwen |4 oth | |
| 700 | 1 | |a Li, Shu |4 oth | |
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10.1016/j.ecoenv.2014.12.002 doi PQ20160617 (DE-627)OLC1964314429 (DE-599)GBVOLC1964314429 (PRQ)c2151-9a943d7afba97153a220e40e7a7ea4ac20183c7249ef34203d1cec70849aea4c0 (KEY)0029001720150000113000000159autophagyisupregulatedinbraintissuesofpigeonsexpos DE-627 ger DE-627 rakwb eng 610 570 DNB 44.13 bkl 44.00 bkl Qu, Jianping verfasserin aut Autophagy is upregulated in brain tissues of pigeons exposed to avermectin 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Avermectin (AVM) is used in agriculture and veterinary medicine for the prevention of parasitic diseases; AVM is the active component of some insecticidal and nematicidal products. Residues of AVM drugs or their metabolites in livestock feces have toxic effects on non-target aquatic and terrestrial organisms. In this study, changes in the levels of autophagy related genes and ultrastructure in pigeon brain tissues after subchronic exposure to AVM for 30, 60 and 90 d were investigated. The decrease in the mRNA levels of TORC1 and TORC2 and increase in the mRNA levels of LC3, Beclin 1, Dynein, ATG5 and ATG4B and the increase in the protein levels of LC3, Beclin 1 and Dynein in a dose- and time-dependent manner in the pigeon brain were observed. The number of autophagic vacuoles in the cerebrum, cerebellum and optic lobe increased significantly with the concentration of AVM and the exposure time. We found that the changes in the levels of autophagy related genes and the ultrastructure in the cerebrum were more obvious than in the cerebellum and the optic lobe. The results suggest that AVM could induce autophagy in pigeon brain tissues. The information presented in this study is helpful for understanding the mechanism of AVM-induced autophagy in birds. Nutzungsrecht: Copyright © 2014 Elsevier Inc. All rights reserved. TOR Serine-Threonine Kinases - metabolism Up-Regulation - drug effects Ivermectin - toxicity RNA, Messenger - metabolism Autophagy - drug effects Brain - metabolism Multiprotein Complexes - metabolism Insecticides - toxicity Dyneins - metabolism Brain - drug effects Brain - ultrastructure Ivermectin - analogs & derivatives Li, Ming oth Zhao, Fuqing oth Liu, Ci oth Zhang, Ziwei oth Xu, Shiwen oth Li, Shu oth Enthalten in Ecotoxicology and environmental safety Amsterdam : Elsevier, 1977 113(2015), Seite 159-168 (DE-627)130055611 (DE-600)436536-7 (DE-576)015593118 0147-6513 nnns volume:113 year:2015 pages:159-168 http://dx.doi.org/10.1016/j.ecoenv.2014.12.002 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25497772 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_70 GBV_ILN_4219 44.13 AVZ 44.00 AVZ AR 113 2015 159-168 |
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10.1016/j.ecoenv.2014.12.002 doi PQ20160617 (DE-627)OLC1964314429 (DE-599)GBVOLC1964314429 (PRQ)c2151-9a943d7afba97153a220e40e7a7ea4ac20183c7249ef34203d1cec70849aea4c0 (KEY)0029001720150000113000000159autophagyisupregulatedinbraintissuesofpigeonsexpos DE-627 ger DE-627 rakwb eng 610 570 DNB 44.13 bkl 44.00 bkl Qu, Jianping verfasserin aut Autophagy is upregulated in brain tissues of pigeons exposed to avermectin 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Avermectin (AVM) is used in agriculture and veterinary medicine for the prevention of parasitic diseases; AVM is the active component of some insecticidal and nematicidal products. Residues of AVM drugs or their metabolites in livestock feces have toxic effects on non-target aquatic and terrestrial organisms. In this study, changes in the levels of autophagy related genes and ultrastructure in pigeon brain tissues after subchronic exposure to AVM for 30, 60 and 90 d were investigated. The decrease in the mRNA levels of TORC1 and TORC2 and increase in the mRNA levels of LC3, Beclin 1, Dynein, ATG5 and ATG4B and the increase in the protein levels of LC3, Beclin 1 and Dynein in a dose- and time-dependent manner in the pigeon brain were observed. The number of autophagic vacuoles in the cerebrum, cerebellum and optic lobe increased significantly with the concentration of AVM and the exposure time. We found that the changes in the levels of autophagy related genes and the ultrastructure in the cerebrum were more obvious than in the cerebellum and the optic lobe. The results suggest that AVM could induce autophagy in pigeon brain tissues. The information presented in this study is helpful for understanding the mechanism of AVM-induced autophagy in birds. Nutzungsrecht: Copyright © 2014 Elsevier Inc. All rights reserved. TOR Serine-Threonine Kinases - metabolism Up-Regulation - drug effects Ivermectin - toxicity RNA, Messenger - metabolism Autophagy - drug effects Brain - metabolism Multiprotein Complexes - metabolism Insecticides - toxicity Dyneins - metabolism Brain - drug effects Brain - ultrastructure Ivermectin - analogs & derivatives Li, Ming oth Zhao, Fuqing oth Liu, Ci oth Zhang, Ziwei oth Xu, Shiwen oth Li, Shu oth Enthalten in Ecotoxicology and environmental safety Amsterdam : Elsevier, 1977 113(2015), Seite 159-168 (DE-627)130055611 (DE-600)436536-7 (DE-576)015593118 0147-6513 nnns volume:113 year:2015 pages:159-168 http://dx.doi.org/10.1016/j.ecoenv.2014.12.002 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25497772 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_70 GBV_ILN_4219 44.13 AVZ 44.00 AVZ AR 113 2015 159-168 |
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10.1016/j.ecoenv.2014.12.002 doi PQ20160617 (DE-627)OLC1964314429 (DE-599)GBVOLC1964314429 (PRQ)c2151-9a943d7afba97153a220e40e7a7ea4ac20183c7249ef34203d1cec70849aea4c0 (KEY)0029001720150000113000000159autophagyisupregulatedinbraintissuesofpigeonsexpos DE-627 ger DE-627 rakwb eng 610 570 DNB 44.13 bkl 44.00 bkl Qu, Jianping verfasserin aut Autophagy is upregulated in brain tissues of pigeons exposed to avermectin 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Avermectin (AVM) is used in agriculture and veterinary medicine for the prevention of parasitic diseases; AVM is the active component of some insecticidal and nematicidal products. Residues of AVM drugs or their metabolites in livestock feces have toxic effects on non-target aquatic and terrestrial organisms. In this study, changes in the levels of autophagy related genes and ultrastructure in pigeon brain tissues after subchronic exposure to AVM for 30, 60 and 90 d were investigated. The decrease in the mRNA levels of TORC1 and TORC2 and increase in the mRNA levels of LC3, Beclin 1, Dynein, ATG5 and ATG4B and the increase in the protein levels of LC3, Beclin 1 and Dynein in a dose- and time-dependent manner in the pigeon brain were observed. The number of autophagic vacuoles in the cerebrum, cerebellum and optic lobe increased significantly with the concentration of AVM and the exposure time. We found that the changes in the levels of autophagy related genes and the ultrastructure in the cerebrum were more obvious than in the cerebellum and the optic lobe. The results suggest that AVM could induce autophagy in pigeon brain tissues. The information presented in this study is helpful for understanding the mechanism of AVM-induced autophagy in birds. Nutzungsrecht: Copyright © 2014 Elsevier Inc. All rights reserved. TOR Serine-Threonine Kinases - metabolism Up-Regulation - drug effects Ivermectin - toxicity RNA, Messenger - metabolism Autophagy - drug effects Brain - metabolism Multiprotein Complexes - metabolism Insecticides - toxicity Dyneins - metabolism Brain - drug effects Brain - ultrastructure Ivermectin - analogs & derivatives Li, Ming oth Zhao, Fuqing oth Liu, Ci oth Zhang, Ziwei oth Xu, Shiwen oth Li, Shu oth Enthalten in Ecotoxicology and environmental safety Amsterdam : Elsevier, 1977 113(2015), Seite 159-168 (DE-627)130055611 (DE-600)436536-7 (DE-576)015593118 0147-6513 nnns volume:113 year:2015 pages:159-168 http://dx.doi.org/10.1016/j.ecoenv.2014.12.002 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25497772 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_70 GBV_ILN_4219 44.13 AVZ 44.00 AVZ AR 113 2015 159-168 |
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10.1016/j.ecoenv.2014.12.002 doi PQ20160617 (DE-627)OLC1964314429 (DE-599)GBVOLC1964314429 (PRQ)c2151-9a943d7afba97153a220e40e7a7ea4ac20183c7249ef34203d1cec70849aea4c0 (KEY)0029001720150000113000000159autophagyisupregulatedinbraintissuesofpigeonsexpos DE-627 ger DE-627 rakwb eng 610 570 DNB 44.13 bkl 44.00 bkl Qu, Jianping verfasserin aut Autophagy is upregulated in brain tissues of pigeons exposed to avermectin 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Avermectin (AVM) is used in agriculture and veterinary medicine for the prevention of parasitic diseases; AVM is the active component of some insecticidal and nematicidal products. Residues of AVM drugs or their metabolites in livestock feces have toxic effects on non-target aquatic and terrestrial organisms. In this study, changes in the levels of autophagy related genes and ultrastructure in pigeon brain tissues after subchronic exposure to AVM for 30, 60 and 90 d were investigated. The decrease in the mRNA levels of TORC1 and TORC2 and increase in the mRNA levels of LC3, Beclin 1, Dynein, ATG5 and ATG4B and the increase in the protein levels of LC3, Beclin 1 and Dynein in a dose- and time-dependent manner in the pigeon brain were observed. The number of autophagic vacuoles in the cerebrum, cerebellum and optic lobe increased significantly with the concentration of AVM and the exposure time. We found that the changes in the levels of autophagy related genes and the ultrastructure in the cerebrum were more obvious than in the cerebellum and the optic lobe. The results suggest that AVM could induce autophagy in pigeon brain tissues. The information presented in this study is helpful for understanding the mechanism of AVM-induced autophagy in birds. Nutzungsrecht: Copyright © 2014 Elsevier Inc. All rights reserved. TOR Serine-Threonine Kinases - metabolism Up-Regulation - drug effects Ivermectin - toxicity RNA, Messenger - metabolism Autophagy - drug effects Brain - metabolism Multiprotein Complexes - metabolism Insecticides - toxicity Dyneins - metabolism Brain - drug effects Brain - ultrastructure Ivermectin - analogs & derivatives Li, Ming oth Zhao, Fuqing oth Liu, Ci oth Zhang, Ziwei oth Xu, Shiwen oth Li, Shu oth Enthalten in Ecotoxicology and environmental safety Amsterdam : Elsevier, 1977 113(2015), Seite 159-168 (DE-627)130055611 (DE-600)436536-7 (DE-576)015593118 0147-6513 nnns volume:113 year:2015 pages:159-168 http://dx.doi.org/10.1016/j.ecoenv.2014.12.002 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25497772 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_70 GBV_ILN_4219 44.13 AVZ 44.00 AVZ AR 113 2015 159-168 |
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10.1016/j.ecoenv.2014.12.002 doi PQ20160617 (DE-627)OLC1964314429 (DE-599)GBVOLC1964314429 (PRQ)c2151-9a943d7afba97153a220e40e7a7ea4ac20183c7249ef34203d1cec70849aea4c0 (KEY)0029001720150000113000000159autophagyisupregulatedinbraintissuesofpigeonsexpos DE-627 ger DE-627 rakwb eng 610 570 DNB 44.13 bkl 44.00 bkl Qu, Jianping verfasserin aut Autophagy is upregulated in brain tissues of pigeons exposed to avermectin 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Avermectin (AVM) is used in agriculture and veterinary medicine for the prevention of parasitic diseases; AVM is the active component of some insecticidal and nematicidal products. Residues of AVM drugs or their metabolites in livestock feces have toxic effects on non-target aquatic and terrestrial organisms. In this study, changes in the levels of autophagy related genes and ultrastructure in pigeon brain tissues after subchronic exposure to AVM for 30, 60 and 90 d were investigated. The decrease in the mRNA levels of TORC1 and TORC2 and increase in the mRNA levels of LC3, Beclin 1, Dynein, ATG5 and ATG4B and the increase in the protein levels of LC3, Beclin 1 and Dynein in a dose- and time-dependent manner in the pigeon brain were observed. The number of autophagic vacuoles in the cerebrum, cerebellum and optic lobe increased significantly with the concentration of AVM and the exposure time. We found that the changes in the levels of autophagy related genes and the ultrastructure in the cerebrum were more obvious than in the cerebellum and the optic lobe. The results suggest that AVM could induce autophagy in pigeon brain tissues. The information presented in this study is helpful for understanding the mechanism of AVM-induced autophagy in birds. Nutzungsrecht: Copyright © 2014 Elsevier Inc. All rights reserved. TOR Serine-Threonine Kinases - metabolism Up-Regulation - drug effects Ivermectin - toxicity RNA, Messenger - metabolism Autophagy - drug effects Brain - metabolism Multiprotein Complexes - metabolism Insecticides - toxicity Dyneins - metabolism Brain - drug effects Brain - ultrastructure Ivermectin - analogs & derivatives Li, Ming oth Zhao, Fuqing oth Liu, Ci oth Zhang, Ziwei oth Xu, Shiwen oth Li, Shu oth Enthalten in Ecotoxicology and environmental safety Amsterdam : Elsevier, 1977 113(2015), Seite 159-168 (DE-627)130055611 (DE-600)436536-7 (DE-576)015593118 0147-6513 nnns volume:113 year:2015 pages:159-168 http://dx.doi.org/10.1016/j.ecoenv.2014.12.002 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25497772 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_70 GBV_ILN_4219 44.13 AVZ 44.00 AVZ AR 113 2015 159-168 |
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Qu, Jianping ddc 610 bkl 44.13 bkl 44.00 misc TOR Serine-Threonine Kinases - metabolism misc Up-Regulation - drug effects misc Ivermectin - toxicity misc RNA, Messenger - metabolism misc Autophagy - drug effects misc Brain - metabolism misc Multiprotein Complexes - metabolism misc Insecticides - toxicity misc Dyneins - metabolism misc Brain - drug effects misc Brain - ultrastructure misc Ivermectin - analogs & derivatives Autophagy is upregulated in brain tissues of pigeons exposed to avermectin |
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610 570 DNB 44.13 bkl 44.00 bkl Autophagy is upregulated in brain tissues of pigeons exposed to avermectin TOR Serine-Threonine Kinases - metabolism Up-Regulation - drug effects Ivermectin - toxicity RNA, Messenger - metabolism Autophagy - drug effects Brain - metabolism Multiprotein Complexes - metabolism Insecticides - toxicity Dyneins - metabolism Brain - drug effects Brain - ultrastructure Ivermectin - analogs & derivatives |
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autophagy is upregulated in brain tissues of pigeons exposed to avermectin |
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Autophagy is upregulated in brain tissues of pigeons exposed to avermectin |
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Avermectin (AVM) is used in agriculture and veterinary medicine for the prevention of parasitic diseases; AVM is the active component of some insecticidal and nematicidal products. Residues of AVM drugs or their metabolites in livestock feces have toxic effects on non-target aquatic and terrestrial organisms. In this study, changes in the levels of autophagy related genes and ultrastructure in pigeon brain tissues after subchronic exposure to AVM for 30, 60 and 90 d were investigated. The decrease in the mRNA levels of TORC1 and TORC2 and increase in the mRNA levels of LC3, Beclin 1, Dynein, ATG5 and ATG4B and the increase in the protein levels of LC3, Beclin 1 and Dynein in a dose- and time-dependent manner in the pigeon brain were observed. The number of autophagic vacuoles in the cerebrum, cerebellum and optic lobe increased significantly with the concentration of AVM and the exposure time. We found that the changes in the levels of autophagy related genes and the ultrastructure in the cerebrum were more obvious than in the cerebellum and the optic lobe. The results suggest that AVM could induce autophagy in pigeon brain tissues. The information presented in this study is helpful for understanding the mechanism of AVM-induced autophagy in birds. |
| abstractGer |
Avermectin (AVM) is used in agriculture and veterinary medicine for the prevention of parasitic diseases; AVM is the active component of some insecticidal and nematicidal products. Residues of AVM drugs or their metabolites in livestock feces have toxic effects on non-target aquatic and terrestrial organisms. In this study, changes in the levels of autophagy related genes and ultrastructure in pigeon brain tissues after subchronic exposure to AVM for 30, 60 and 90 d were investigated. The decrease in the mRNA levels of TORC1 and TORC2 and increase in the mRNA levels of LC3, Beclin 1, Dynein, ATG5 and ATG4B and the increase in the protein levels of LC3, Beclin 1 and Dynein in a dose- and time-dependent manner in the pigeon brain were observed. The number of autophagic vacuoles in the cerebrum, cerebellum and optic lobe increased significantly with the concentration of AVM and the exposure time. We found that the changes in the levels of autophagy related genes and the ultrastructure in the cerebrum were more obvious than in the cerebellum and the optic lobe. The results suggest that AVM could induce autophagy in pigeon brain tissues. The information presented in this study is helpful for understanding the mechanism of AVM-induced autophagy in birds. |
| abstract_unstemmed |
Avermectin (AVM) is used in agriculture and veterinary medicine for the prevention of parasitic diseases; AVM is the active component of some insecticidal and nematicidal products. Residues of AVM drugs or their metabolites in livestock feces have toxic effects on non-target aquatic and terrestrial organisms. In this study, changes in the levels of autophagy related genes and ultrastructure in pigeon brain tissues after subchronic exposure to AVM for 30, 60 and 90 d were investigated. The decrease in the mRNA levels of TORC1 and TORC2 and increase in the mRNA levels of LC3, Beclin 1, Dynein, ATG5 and ATG4B and the increase in the protein levels of LC3, Beclin 1 and Dynein in a dose- and time-dependent manner in the pigeon brain were observed. The number of autophagic vacuoles in the cerebrum, cerebellum and optic lobe increased significantly with the concentration of AVM and the exposure time. We found that the changes in the levels of autophagy related genes and the ultrastructure in the cerebrum were more obvious than in the cerebellum and the optic lobe. The results suggest that AVM could induce autophagy in pigeon brain tissues. The information presented in this study is helpful for understanding the mechanism of AVM-induced autophagy in birds. |
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| title_short |
Autophagy is upregulated in brain tissues of pigeons exposed to avermectin |
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http://dx.doi.org/10.1016/j.ecoenv.2014.12.002 http://www.ncbi.nlm.nih.gov/pubmed/25497772 |
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Li, Ming Zhao, Fuqing Liu, Ci Zhang, Ziwei Xu, Shiwen Li, Shu |
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