DNA interactions, antitumor activities and radical scavenging properties of oxovanadium complexes with pyrazino[2,3-f][1,10]phenanthroline ligands
Two unsymmetrical oxovanadium complexes [VO(satsc)(dpq)] (1) (satsc = salicylaldehyde thiosemicarbazone, dpq = pyrazino[2,3-f][1,10]phenanthroline) and [VO(hntdtsc)(dpq)] (2) (hntdtsc = 2-hydroxy-1-naphthaldehyde thiosemicarbazone) have been synthesized and characterized. Both complexes show strong...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Zeng, Pengfei [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Rechteinformationen: |
Nutzungsrecht: © Springer International Publishing Switzerland 2015 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Transition metal chemistry - Dordrecht [u.a.] : Springer, 1975, 40(2015), 8, Seite 779-787 |
|---|---|
| Übergeordnetes Werk: |
volume:40 ; year:2015 ; number:8 ; pages:779-787 |
| Links: |
|---|
| DOI / URN: |
10.1007/s11243-015-9939-9 |
|---|
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OLC1964391873 |
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| 520 | |a Two unsymmetrical oxovanadium complexes [VO(satsc)(dpq)] (1) (satsc = salicylaldehyde thiosemicarbazone, dpq = pyrazino[2,3-f][1,10]phenanthroline) and [VO(hntdtsc)(dpq)] (2) (hntdtsc = 2-hydroxy-1-naphthaldehyde thiosemicarbazone) have been synthesized and characterized. Both complexes show strong interactions with calf thymus DNA through an intercalative model and can efficiently cleave pBR322 DNA after irradiation with light. Both complexes also exhibit high cytotoxicities against SH-SY5Y, MCF-7 and SK-N-SH cell lines. Complex 2 was found to have higher antitumor potency, DNA-binding affinity and DNA-cleaving ability than complex 1. The abilities of these complexes to scavenge hydroxy radicals were evaluated. | ||
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10.1007/s11243-015-9939-9 doi PQ20160617 (DE-627)OLC1964391873 (DE-599)GBVOLC1964391873 (PRQ)s971-8226b433b26e94733a5032f4f58a52039c6de38850f0666b3ddb2683a454a7d50 (KEY)0030475120150000040000800779dnainteractionsantitumoractivitiesandradicalscaven DE-627 ger DE-627 rakwb eng 18a 500 520 530 540 550 560 570 580 590 DNB 660 AVZ Zeng, Pengfei verfasserin aut DNA interactions, antitumor activities and radical scavenging properties of oxovanadium complexes with pyrazino[2,3-f][1,10]phenanthroline ligands 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Two unsymmetrical oxovanadium complexes [VO(satsc)(dpq)] (1) (satsc = salicylaldehyde thiosemicarbazone, dpq = pyrazino[2,3-f][1,10]phenanthroline) and [VO(hntdtsc)(dpq)] (2) (hntdtsc = 2-hydroxy-1-naphthaldehyde thiosemicarbazone) have been synthesized and characterized. Both complexes show strong interactions with calf thymus DNA through an intercalative model and can efficiently cleave pBR322 DNA after irradiation with light. Both complexes also exhibit high cytotoxicities against SH-SY5Y, MCF-7 and SK-N-SH cell lines. Complex 2 was found to have higher antitumor potency, DNA-binding affinity and DNA-cleaving ability than complex 1. The abilities of these complexes to scavenge hydroxy radicals were evaluated. Nutzungsrecht: © Springer International Publishing Switzerland 2015 Chemistry Physical Chemistry Inorganic Chemistry Catalysis He, Limin oth Ye, Zhenfeng oth Yang, Ning oth Song, Yulan oth Lu, Jiazheng oth Enthalten in Transition metal chemistry Dordrecht [u.a.] : Springer, 1975 40(2015), 8, Seite 779-787 (DE-627)129605417 (DE-600)242084-3 (DE-576)015099652 0340-4285 nnns volume:40 year:2015 number:8 pages:779-787 http://dx.doi.org/10.1007/s11243-015-9939-9 Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 GBV_ILN_4012 GBV_ILN_4125 AR 40 2015 8 779-787 |
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10.1007/s11243-015-9939-9 doi PQ20160617 (DE-627)OLC1964391873 (DE-599)GBVOLC1964391873 (PRQ)s971-8226b433b26e94733a5032f4f58a52039c6de38850f0666b3ddb2683a454a7d50 (KEY)0030475120150000040000800779dnainteractionsantitumoractivitiesandradicalscaven DE-627 ger DE-627 rakwb eng 18a 500 520 530 540 550 560 570 580 590 DNB 660 AVZ Zeng, Pengfei verfasserin aut DNA interactions, antitumor activities and radical scavenging properties of oxovanadium complexes with pyrazino[2,3-f][1,10]phenanthroline ligands 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Two unsymmetrical oxovanadium complexes [VO(satsc)(dpq)] (1) (satsc = salicylaldehyde thiosemicarbazone, dpq = pyrazino[2,3-f][1,10]phenanthroline) and [VO(hntdtsc)(dpq)] (2) (hntdtsc = 2-hydroxy-1-naphthaldehyde thiosemicarbazone) have been synthesized and characterized. Both complexes show strong interactions with calf thymus DNA through an intercalative model and can efficiently cleave pBR322 DNA after irradiation with light. Both complexes also exhibit high cytotoxicities against SH-SY5Y, MCF-7 and SK-N-SH cell lines. Complex 2 was found to have higher antitumor potency, DNA-binding affinity and DNA-cleaving ability than complex 1. The abilities of these complexes to scavenge hydroxy radicals were evaluated. Nutzungsrecht: © Springer International Publishing Switzerland 2015 Chemistry Physical Chemistry Inorganic Chemistry Catalysis He, Limin oth Ye, Zhenfeng oth Yang, Ning oth Song, Yulan oth Lu, Jiazheng oth Enthalten in Transition metal chemistry Dordrecht [u.a.] : Springer, 1975 40(2015), 8, Seite 779-787 (DE-627)129605417 (DE-600)242084-3 (DE-576)015099652 0340-4285 nnns volume:40 year:2015 number:8 pages:779-787 http://dx.doi.org/10.1007/s11243-015-9939-9 Volltext GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 GBV_ILN_4012 GBV_ILN_4125 AR 40 2015 8 779-787 |
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DNA interactions, antitumor activities and radical scavenging properties of oxovanadium complexes with pyrazino[2,3-f][1,10]phenanthroline ligands |
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DNA interactions, antitumor activities and radical scavenging properties of oxovanadium complexes with pyrazino[2,3-f][1,10]phenanthroline ligands |
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Zeng, Pengfei |
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Transition metal chemistry |
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dna interactions, antitumor activities and radical scavenging properties of oxovanadium complexes with pyrazino[2,3-f][1,10]phenanthroline ligands |
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DNA interactions, antitumor activities and radical scavenging properties of oxovanadium complexes with pyrazino[2,3-f][1,10]phenanthroline ligands |
| abstract |
Two unsymmetrical oxovanadium complexes [VO(satsc)(dpq)] (1) (satsc = salicylaldehyde thiosemicarbazone, dpq = pyrazino[2,3-f][1,10]phenanthroline) and [VO(hntdtsc)(dpq)] (2) (hntdtsc = 2-hydroxy-1-naphthaldehyde thiosemicarbazone) have been synthesized and characterized. Both complexes show strong interactions with calf thymus DNA through an intercalative model and can efficiently cleave pBR322 DNA after irradiation with light. Both complexes also exhibit high cytotoxicities against SH-SY5Y, MCF-7 and SK-N-SH cell lines. Complex 2 was found to have higher antitumor potency, DNA-binding affinity and DNA-cleaving ability than complex 1. The abilities of these complexes to scavenge hydroxy radicals were evaluated. |
| abstractGer |
Two unsymmetrical oxovanadium complexes [VO(satsc)(dpq)] (1) (satsc = salicylaldehyde thiosemicarbazone, dpq = pyrazino[2,3-f][1,10]phenanthroline) and [VO(hntdtsc)(dpq)] (2) (hntdtsc = 2-hydroxy-1-naphthaldehyde thiosemicarbazone) have been synthesized and characterized. Both complexes show strong interactions with calf thymus DNA through an intercalative model and can efficiently cleave pBR322 DNA after irradiation with light. Both complexes also exhibit high cytotoxicities against SH-SY5Y, MCF-7 and SK-N-SH cell lines. Complex 2 was found to have higher antitumor potency, DNA-binding affinity and DNA-cleaving ability than complex 1. The abilities of these complexes to scavenge hydroxy radicals were evaluated. |
| abstract_unstemmed |
Two unsymmetrical oxovanadium complexes [VO(satsc)(dpq)] (1) (satsc = salicylaldehyde thiosemicarbazone, dpq = pyrazino[2,3-f][1,10]phenanthroline) and [VO(hntdtsc)(dpq)] (2) (hntdtsc = 2-hydroxy-1-naphthaldehyde thiosemicarbazone) have been synthesized and characterized. Both complexes show strong interactions with calf thymus DNA through an intercalative model and can efficiently cleave pBR322 DNA after irradiation with light. Both complexes also exhibit high cytotoxicities against SH-SY5Y, MCF-7 and SK-N-SH cell lines. Complex 2 was found to have higher antitumor potency, DNA-binding affinity and DNA-cleaving ability than complex 1. The abilities of these complexes to scavenge hydroxy radicals were evaluated. |
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DNA interactions, antitumor activities and radical scavenging properties of oxovanadium complexes with pyrazino[2,3-f][1,10]phenanthroline ligands |
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He, Limin Ye, Zhenfeng Yang, Ning Song, Yulan Lu, Jiazheng |
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