Quantitative analyses of the effect of silk fibroin/nano-hydroxyapatite composites on osteogenic differentiation of MG-63 human osteosarcoma cells
Silk fibroin (SF)/nano-hydroxyapatite (n-HA) composites are potential biomaterials for bone defect repair. Up to now, the biological evaluation studies of SF/n-HA composites have primarily concentrated on their biocompatibility at cell level such as cell viability and proliferation and tissue level...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Lin, Linxue [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Rechteinformationen: |
Nutzungsrecht: Copyright © 2014 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved. |
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| Schlagwörter: |
Nanoparticles - ultrastructure Cell Proliferation - drug effects Cell Differentiation - drug effects Biocompatible Materials - chemistry |
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| Übergeordnetes Werk: |
Enthalten in: Journal of bioscience and bioengineering - Osaka, 1999, 119(2015), 5, Seite 591 |
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| Übergeordnetes Werk: |
volume:119 ; year:2015 ; number:5 ; pages:591 |
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| DOI / URN: |
10.1016/j.jbiosc.2014.10.009 |
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| 520 | |a Silk fibroin (SF)/nano-hydroxyapatite (n-HA) composites are potential biomaterials for bone defect repair. Up to now, the biological evaluation studies of SF/n-HA composites have primarily concentrated on their biocompatibility at cell level such as cell viability and proliferation and tissue level such as material absorption and new bone formation. In this work, SF/n-HA composites were fabricated using a simplified coprecipitation methods and were deposited onto Ti alloy substrates. Then the cell adhesion ability of SF/n-HA composites was observed by SEM and cell proliferation ability of SF/n-HA composites was determined by MTT assay. The ALP activity, BGP contents, and Col I contents of MG-63 human osteosarcoma cells on SF/n-HA composites were quantitatively analyzed. HA nanocrystals were used as controls. These experiments showed that SF/n-HA composites had better cell adhesion and osteogenic differentiation abilities than n-HA materials. This work provides quantitative data to analyze the effect of SF/n-HA composites on cell osteogenic differentiation. | ||
| 540 | |a Nutzungsrecht: Copyright © 2014 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved. | ||
| 650 | 4 | |a Fibroins - ultrastructure | |
| 650 | 4 | |a Fibroins - pharmacology | |
| 650 | 4 | |a Nanoparticles - ultrastructure | |
| 650 | 4 | |a Silk - pharmacology | |
| 650 | 4 | |a Durapatite - pharmacology | |
| 650 | 4 | |a Osteosarcoma - pathology | |
| 650 | 4 | |a Cell Proliferation - drug effects | |
| 650 | 4 | |a Cell Differentiation - drug effects | |
| 650 | 4 | |a Durapatite - chemistry | |
| 650 | 4 | |a Biocompatible Materials - chemistry | |
| 650 | 4 | |a Silk - chemistry | |
| 650 | 4 | |a Fibroins - chemistry | |
| 650 | 4 | |a Cell Adhesion - drug effects | |
| 650 | 4 | |a Biocompatible Materials - pharmacology | |
| 650 | 4 | |a Osteogenesis - drug effects | |
| 650 | 4 | |a Nanoparticles - chemistry | |
| 650 | 4 | |a Silk - ultrastructure | |
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| 700 | 1 | |a Xiong, Wei |4 oth | |
| 700 | 1 | |a Zhong, Jian |4 oth | |
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10.1016/j.jbiosc.2014.10.009 doi PQ20160617 (DE-627)OLC1965022294 (DE-599)GBVOLC1965022294 (PRQ)c1287-96947a5addfbf7c27a4d03c03dea67b1dd6f2f5b870f15af2050fe7a3dc9e14f0 (KEY)0039398320150000119000500591quantitativeanalysesoftheeffectofsilkfibroinnanohy DE-627 ger DE-627 rakwb eng 570 540 660 DNB 42.00 bkl 58.30 bkl 48.00 bkl Lin, Linxue verfasserin aut Quantitative analyses of the effect of silk fibroin/nano-hydroxyapatite composites on osteogenic differentiation of MG-63 human osteosarcoma cells 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Silk fibroin (SF)/nano-hydroxyapatite (n-HA) composites are potential biomaterials for bone defect repair. Up to now, the biological evaluation studies of SF/n-HA composites have primarily concentrated on their biocompatibility at cell level such as cell viability and proliferation and tissue level such as material absorption and new bone formation. In this work, SF/n-HA composites were fabricated using a simplified coprecipitation methods and were deposited onto Ti alloy substrates. Then the cell adhesion ability of SF/n-HA composites was observed by SEM and cell proliferation ability of SF/n-HA composites was determined by MTT assay. The ALP activity, BGP contents, and Col I contents of MG-63 human osteosarcoma cells on SF/n-HA composites were quantitatively analyzed. HA nanocrystals were used as controls. These experiments showed that SF/n-HA composites had better cell adhesion and osteogenic differentiation abilities than n-HA materials. This work provides quantitative data to analyze the effect of SF/n-HA composites on cell osteogenic differentiation. Nutzungsrecht: Copyright © 2014 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved. Fibroins - ultrastructure Fibroins - pharmacology Nanoparticles - ultrastructure Silk - pharmacology Durapatite - pharmacology Osteosarcoma - pathology Cell Proliferation - drug effects Cell Differentiation - drug effects Durapatite - chemistry Biocompatible Materials - chemistry Silk - chemistry Fibroins - chemistry Cell Adhesion - drug effects Biocompatible Materials - pharmacology Osteogenesis - drug effects Nanoparticles - chemistry Silk - ultrastructure Hao, Runsong oth Xiong, Wei oth Zhong, Jian oth Enthalten in Journal of bioscience and bioengineering Osaka, 1999 119(2015), 5, Seite 591 (DE-627)265549817 (DE-600)1465387-4 (DE-576)074842005 1389-1723 nnns volume:119 year:2015 number:5 pages:591 http://dx.doi.org/10.1016/j.jbiosc.2014.10.009 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25454062 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-FOR GBV_ILN_70 42.00 AVZ 58.30 AVZ 48.00 AVZ AR 119 2015 5 591 |
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10.1016/j.jbiosc.2014.10.009 doi PQ20160617 (DE-627)OLC1965022294 (DE-599)GBVOLC1965022294 (PRQ)c1287-96947a5addfbf7c27a4d03c03dea67b1dd6f2f5b870f15af2050fe7a3dc9e14f0 (KEY)0039398320150000119000500591quantitativeanalysesoftheeffectofsilkfibroinnanohy DE-627 ger DE-627 rakwb eng 570 540 660 DNB 42.00 bkl 58.30 bkl 48.00 bkl Lin, Linxue verfasserin aut Quantitative analyses of the effect of silk fibroin/nano-hydroxyapatite composites on osteogenic differentiation of MG-63 human osteosarcoma cells 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Silk fibroin (SF)/nano-hydroxyapatite (n-HA) composites are potential biomaterials for bone defect repair. Up to now, the biological evaluation studies of SF/n-HA composites have primarily concentrated on their biocompatibility at cell level such as cell viability and proliferation and tissue level such as material absorption and new bone formation. In this work, SF/n-HA composites were fabricated using a simplified coprecipitation methods and were deposited onto Ti alloy substrates. Then the cell adhesion ability of SF/n-HA composites was observed by SEM and cell proliferation ability of SF/n-HA composites was determined by MTT assay. The ALP activity, BGP contents, and Col I contents of MG-63 human osteosarcoma cells on SF/n-HA composites were quantitatively analyzed. HA nanocrystals were used as controls. These experiments showed that SF/n-HA composites had better cell adhesion and osteogenic differentiation abilities than n-HA materials. This work provides quantitative data to analyze the effect of SF/n-HA composites on cell osteogenic differentiation. Nutzungsrecht: Copyright © 2014 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved. Fibroins - ultrastructure Fibroins - pharmacology Nanoparticles - ultrastructure Silk - pharmacology Durapatite - pharmacology Osteosarcoma - pathology Cell Proliferation - drug effects Cell Differentiation - drug effects Durapatite - chemistry Biocompatible Materials - chemistry Silk - chemistry Fibroins - chemistry Cell Adhesion - drug effects Biocompatible Materials - pharmacology Osteogenesis - drug effects Nanoparticles - chemistry Silk - ultrastructure Hao, Runsong oth Xiong, Wei oth Zhong, Jian oth Enthalten in Journal of bioscience and bioengineering Osaka, 1999 119(2015), 5, Seite 591 (DE-627)265549817 (DE-600)1465387-4 (DE-576)074842005 1389-1723 nnns volume:119 year:2015 number:5 pages:591 http://dx.doi.org/10.1016/j.jbiosc.2014.10.009 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25454062 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-FOR GBV_ILN_70 42.00 AVZ 58.30 AVZ 48.00 AVZ AR 119 2015 5 591 |
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10.1016/j.jbiosc.2014.10.009 doi PQ20160617 (DE-627)OLC1965022294 (DE-599)GBVOLC1965022294 (PRQ)c1287-96947a5addfbf7c27a4d03c03dea67b1dd6f2f5b870f15af2050fe7a3dc9e14f0 (KEY)0039398320150000119000500591quantitativeanalysesoftheeffectofsilkfibroinnanohy DE-627 ger DE-627 rakwb eng 570 540 660 DNB 42.00 bkl 58.30 bkl 48.00 bkl Lin, Linxue verfasserin aut Quantitative analyses of the effect of silk fibroin/nano-hydroxyapatite composites on osteogenic differentiation of MG-63 human osteosarcoma cells 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Silk fibroin (SF)/nano-hydroxyapatite (n-HA) composites are potential biomaterials for bone defect repair. Up to now, the biological evaluation studies of SF/n-HA composites have primarily concentrated on their biocompatibility at cell level such as cell viability and proliferation and tissue level such as material absorption and new bone formation. In this work, SF/n-HA composites were fabricated using a simplified coprecipitation methods and were deposited onto Ti alloy substrates. Then the cell adhesion ability of SF/n-HA composites was observed by SEM and cell proliferation ability of SF/n-HA composites was determined by MTT assay. The ALP activity, BGP contents, and Col I contents of MG-63 human osteosarcoma cells on SF/n-HA composites were quantitatively analyzed. HA nanocrystals were used as controls. These experiments showed that SF/n-HA composites had better cell adhesion and osteogenic differentiation abilities than n-HA materials. This work provides quantitative data to analyze the effect of SF/n-HA composites on cell osteogenic differentiation. Nutzungsrecht: Copyright © 2014 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved. Fibroins - ultrastructure Fibroins - pharmacology Nanoparticles - ultrastructure Silk - pharmacology Durapatite - pharmacology Osteosarcoma - pathology Cell Proliferation - drug effects Cell Differentiation - drug effects Durapatite - chemistry Biocompatible Materials - chemistry Silk - chemistry Fibroins - chemistry Cell Adhesion - drug effects Biocompatible Materials - pharmacology Osteogenesis - drug effects Nanoparticles - chemistry Silk - ultrastructure Hao, Runsong oth Xiong, Wei oth Zhong, Jian oth Enthalten in Journal of bioscience and bioengineering Osaka, 1999 119(2015), 5, Seite 591 (DE-627)265549817 (DE-600)1465387-4 (DE-576)074842005 1389-1723 nnns volume:119 year:2015 number:5 pages:591 http://dx.doi.org/10.1016/j.jbiosc.2014.10.009 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25454062 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-FOR GBV_ILN_70 42.00 AVZ 58.30 AVZ 48.00 AVZ AR 119 2015 5 591 |
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10.1016/j.jbiosc.2014.10.009 doi PQ20160617 (DE-627)OLC1965022294 (DE-599)GBVOLC1965022294 (PRQ)c1287-96947a5addfbf7c27a4d03c03dea67b1dd6f2f5b870f15af2050fe7a3dc9e14f0 (KEY)0039398320150000119000500591quantitativeanalysesoftheeffectofsilkfibroinnanohy DE-627 ger DE-627 rakwb eng 570 540 660 DNB 42.00 bkl 58.30 bkl 48.00 bkl Lin, Linxue verfasserin aut Quantitative analyses of the effect of silk fibroin/nano-hydroxyapatite composites on osteogenic differentiation of MG-63 human osteosarcoma cells 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Silk fibroin (SF)/nano-hydroxyapatite (n-HA) composites are potential biomaterials for bone defect repair. Up to now, the biological evaluation studies of SF/n-HA composites have primarily concentrated on their biocompatibility at cell level such as cell viability and proliferation and tissue level such as material absorption and new bone formation. In this work, SF/n-HA composites were fabricated using a simplified coprecipitation methods and were deposited onto Ti alloy substrates. Then the cell adhesion ability of SF/n-HA composites was observed by SEM and cell proliferation ability of SF/n-HA composites was determined by MTT assay. The ALP activity, BGP contents, and Col I contents of MG-63 human osteosarcoma cells on SF/n-HA composites were quantitatively analyzed. HA nanocrystals were used as controls. These experiments showed that SF/n-HA composites had better cell adhesion and osteogenic differentiation abilities than n-HA materials. This work provides quantitative data to analyze the effect of SF/n-HA composites on cell osteogenic differentiation. Nutzungsrecht: Copyright © 2014 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved. Fibroins - ultrastructure Fibroins - pharmacology Nanoparticles - ultrastructure Silk - pharmacology Durapatite - pharmacology Osteosarcoma - pathology Cell Proliferation - drug effects Cell Differentiation - drug effects Durapatite - chemistry Biocompatible Materials - chemistry Silk - chemistry Fibroins - chemistry Cell Adhesion - drug effects Biocompatible Materials - pharmacology Osteogenesis - drug effects Nanoparticles - chemistry Silk - ultrastructure Hao, Runsong oth Xiong, Wei oth Zhong, Jian oth Enthalten in Journal of bioscience and bioengineering Osaka, 1999 119(2015), 5, Seite 591 (DE-627)265549817 (DE-600)1465387-4 (DE-576)074842005 1389-1723 nnns volume:119 year:2015 number:5 pages:591 http://dx.doi.org/10.1016/j.jbiosc.2014.10.009 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25454062 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-FOR GBV_ILN_70 42.00 AVZ 58.30 AVZ 48.00 AVZ AR 119 2015 5 591 |
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Lin, Linxue ddc 570 bkl 42.00 bkl 58.30 bkl 48.00 misc Fibroins - ultrastructure misc Fibroins - pharmacology misc Nanoparticles - ultrastructure misc Silk - pharmacology misc Durapatite - pharmacology misc Osteosarcoma - pathology misc Cell Proliferation - drug effects misc Cell Differentiation - drug effects misc Durapatite - chemistry misc Biocompatible Materials - chemistry misc Silk - chemistry misc Fibroins - chemistry misc Cell Adhesion - drug effects misc Biocompatible Materials - pharmacology misc Osteogenesis - drug effects misc Nanoparticles - chemistry misc Silk - ultrastructure Quantitative analyses of the effect of silk fibroin/nano-hydroxyapatite composites on osteogenic differentiation of MG-63 human osteosarcoma cells |
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570 540 660 DNB 42.00 bkl 58.30 bkl 48.00 bkl Quantitative analyses of the effect of silk fibroin/nano-hydroxyapatite composites on osteogenic differentiation of MG-63 human osteosarcoma cells Fibroins - ultrastructure Fibroins - pharmacology Nanoparticles - ultrastructure Silk - pharmacology Durapatite - pharmacology Osteosarcoma - pathology Cell Proliferation - drug effects Cell Differentiation - drug effects Durapatite - chemistry Biocompatible Materials - chemistry Silk - chemistry Fibroins - chemistry Cell Adhesion - drug effects Biocompatible Materials - pharmacology Osteogenesis - drug effects Nanoparticles - chemistry Silk - ultrastructure |
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Quantitative analyses of the effect of silk fibroin/nano-hydroxyapatite composites on osteogenic differentiation of MG-63 human osteosarcoma cells |
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Quantitative analyses of the effect of silk fibroin/nano-hydroxyapatite composites on osteogenic differentiation of MG-63 human osteosarcoma cells |
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quantitative analyses of the effect of silk fibroin/nano-hydroxyapatite composites on osteogenic differentiation of mg-63 human osteosarcoma cells |
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Quantitative analyses of the effect of silk fibroin/nano-hydroxyapatite composites on osteogenic differentiation of MG-63 human osteosarcoma cells |
| abstract |
Silk fibroin (SF)/nano-hydroxyapatite (n-HA) composites are potential biomaterials for bone defect repair. Up to now, the biological evaluation studies of SF/n-HA composites have primarily concentrated on their biocompatibility at cell level such as cell viability and proliferation and tissue level such as material absorption and new bone formation. In this work, SF/n-HA composites were fabricated using a simplified coprecipitation methods and were deposited onto Ti alloy substrates. Then the cell adhesion ability of SF/n-HA composites was observed by SEM and cell proliferation ability of SF/n-HA composites was determined by MTT assay. The ALP activity, BGP contents, and Col I contents of MG-63 human osteosarcoma cells on SF/n-HA composites were quantitatively analyzed. HA nanocrystals were used as controls. These experiments showed that SF/n-HA composites had better cell adhesion and osteogenic differentiation abilities than n-HA materials. This work provides quantitative data to analyze the effect of SF/n-HA composites on cell osteogenic differentiation. |
| abstractGer |
Silk fibroin (SF)/nano-hydroxyapatite (n-HA) composites are potential biomaterials for bone defect repair. Up to now, the biological evaluation studies of SF/n-HA composites have primarily concentrated on their biocompatibility at cell level such as cell viability and proliferation and tissue level such as material absorption and new bone formation. In this work, SF/n-HA composites were fabricated using a simplified coprecipitation methods and were deposited onto Ti alloy substrates. Then the cell adhesion ability of SF/n-HA composites was observed by SEM and cell proliferation ability of SF/n-HA composites was determined by MTT assay. The ALP activity, BGP contents, and Col I contents of MG-63 human osteosarcoma cells on SF/n-HA composites were quantitatively analyzed. HA nanocrystals were used as controls. These experiments showed that SF/n-HA composites had better cell adhesion and osteogenic differentiation abilities than n-HA materials. This work provides quantitative data to analyze the effect of SF/n-HA composites on cell osteogenic differentiation. |
| abstract_unstemmed |
Silk fibroin (SF)/nano-hydroxyapatite (n-HA) composites are potential biomaterials for bone defect repair. Up to now, the biological evaluation studies of SF/n-HA composites have primarily concentrated on their biocompatibility at cell level such as cell viability and proliferation and tissue level such as material absorption and new bone formation. In this work, SF/n-HA composites were fabricated using a simplified coprecipitation methods and were deposited onto Ti alloy substrates. Then the cell adhesion ability of SF/n-HA composites was observed by SEM and cell proliferation ability of SF/n-HA composites was determined by MTT assay. The ALP activity, BGP contents, and Col I contents of MG-63 human osteosarcoma cells on SF/n-HA composites were quantitatively analyzed. HA nanocrystals were used as controls. These experiments showed that SF/n-HA composites had better cell adhesion and osteogenic differentiation abilities than n-HA materials. This work provides quantitative data to analyze the effect of SF/n-HA composites on cell osteogenic differentiation. |
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Quantitative analyses of the effect of silk fibroin/nano-hydroxyapatite composites on osteogenic differentiation of MG-63 human osteosarcoma cells |
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