Subacute oral toxicity of cocoa tea (Camellia ptilophylla) water extract in SD rats
Camellia ptilophylla , known as cocoa tea, is a natural decaffeinated tea plant which has been proved with potential bioactivities. This study was carried out to evaluate the safety of green cocoa tea water extract ( CWE ) by determining its potential toxicity after subacute administration in SD rat...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Li, Kaikai [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Rechteinformationen: |
Nutzungsrecht: © 2015 Institute of Food Science and Technology |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: International journal of food science & technology - Oxford : Blackwell, 1987, 50(2015), 11, Seite 2391-2401 |
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| Übergeordnetes Werk: |
volume:50 ; year:2015 ; number:11 ; pages:2391-2401 |
| Links: |
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| DOI / URN: |
10.1111/ijfs.12905 |
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OLC1965115322 |
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| 520 | |a Camellia ptilophylla , known as cocoa tea, is a natural decaffeinated tea plant which has been proved with potential bioactivities. This study was carried out to evaluate the safety of green cocoa tea water extract ( CWE ) by determining its potential toxicity after subacute administration in SD rats. In the subacute toxicity study, oral administration of CWE up to 800 mg kg −1 body weight day −1 for twenty‐eight consecutive days did not cause either mortality or toxicity in SD rats, regardless of gender. There were no adverse effects in body weight, food consumption, relative organ weight, haematological parameters, clinical chemistry, gross pathology and histopathology between treatment and control groups. Several parameters (e.g. neutrophils%, Ca 2+ , total Ca) in CWE ‐treated rats with high dosage were significantly different from the control groups, but still in a safety level. A dose of 800 mg kg −1 day −1 was identified as the no observed adverse effect level ( NOAEL ) in this study. The body weight of SD rats treated orally with cocoa green tea water extract for 28 days. | ||
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| 650 | 4 | |a natural decaffeinated tea | |
| 650 | 4 | |a subacute toxicity | |
| 650 | 4 | |a Green cocoa tea water extract | |
| 650 | 4 | |a Toxicity | |
| 650 | 4 | |a Food science | |
| 650 | 4 | |a Tea | |
| 650 | 4 | |a Rodents | |
| 700 | 1 | |a Zhou, Xuelin |4 oth | |
| 700 | 1 | |a Yang, Xiaorong |4 oth | |
| 700 | 1 | |a Shi, Xianggang |4 oth | |
| 700 | 1 | |a Song, Xiaohong |4 oth | |
| 700 | 1 | |a Ye, Chuangxing |4 oth | |
| 700 | 1 | |a Ko, Chun Hay |4 oth | |
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10.1111/ijfs.12905 doi PQ20160617 (DE-627)OLC1965115322 (DE-599)GBVOLC1965115322 (PRQ)c1885-1ac23f4f89892a82889eef4d12f43b4a8e13a11099b4bbbb41f2ddb40ef406440 (KEY)0040074220150000050001102391subacuteoraltoxicityofcocoateacamelliaptilophyllaw DE-627 ger DE-627 rakwb eng 630 640 610 660 DNB Li, Kaikai verfasserin aut Subacute oral toxicity of cocoa tea (Camellia ptilophylla) water extract in SD rats 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Camellia ptilophylla , known as cocoa tea, is a natural decaffeinated tea plant which has been proved with potential bioactivities. This study was carried out to evaluate the safety of green cocoa tea water extract ( CWE ) by determining its potential toxicity after subacute administration in SD rats. In the subacute toxicity study, oral administration of CWE up to 800 mg kg −1 body weight day −1 for twenty‐eight consecutive days did not cause either mortality or toxicity in SD rats, regardless of gender. There were no adverse effects in body weight, food consumption, relative organ weight, haematological parameters, clinical chemistry, gross pathology and histopathology between treatment and control groups. Several parameters (e.g. neutrophils%, Ca 2+ , total Ca) in CWE ‐treated rats with high dosage were significantly different from the control groups, but still in a safety level. A dose of 800 mg kg −1 day −1 was identified as the no observed adverse effect level ( NOAEL ) in this study. The body weight of SD rats treated orally with cocoa green tea water extract for 28 days. Nutzungsrecht: © 2015 Institute of Food Science and Technology natural decaffeinated tea subacute toxicity Green cocoa tea water extract Toxicity Food science Tea Rodents Zhou, Xuelin oth Yang, Xiaorong oth Shi, Xianggang oth Song, Xiaohong oth Ye, Chuangxing oth Ko, Chun Hay oth Enthalten in International journal of food science & technology Oxford : Blackwell, 1987 50(2015), 11, Seite 2391-2401 (DE-627)130679712 (DE-600)883561-5 (DE-576)016221885 0950-5423 nnns volume:50 year:2015 number:11 pages:2391-2401 http://dx.doi.org/10.1111/ijfs.12905 Volltext http://onlinelibrary.wiley.com/doi/10.1111/ijfs.12905/abstract http://search.proquest.com/docview/1721587675 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_4219 AR 50 2015 11 2391-2401 |
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10.1111/ijfs.12905 doi PQ20160617 (DE-627)OLC1965115322 (DE-599)GBVOLC1965115322 (PRQ)c1885-1ac23f4f89892a82889eef4d12f43b4a8e13a11099b4bbbb41f2ddb40ef406440 (KEY)0040074220150000050001102391subacuteoraltoxicityofcocoateacamelliaptilophyllaw DE-627 ger DE-627 rakwb eng 630 640 610 660 DNB Li, Kaikai verfasserin aut Subacute oral toxicity of cocoa tea (Camellia ptilophylla) water extract in SD rats 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Camellia ptilophylla , known as cocoa tea, is a natural decaffeinated tea plant which has been proved with potential bioactivities. This study was carried out to evaluate the safety of green cocoa tea water extract ( CWE ) by determining its potential toxicity after subacute administration in SD rats. In the subacute toxicity study, oral administration of CWE up to 800 mg kg −1 body weight day −1 for twenty‐eight consecutive days did not cause either mortality or toxicity in SD rats, regardless of gender. There were no adverse effects in body weight, food consumption, relative organ weight, haematological parameters, clinical chemistry, gross pathology and histopathology between treatment and control groups. Several parameters (e.g. neutrophils%, Ca 2+ , total Ca) in CWE ‐treated rats with high dosage were significantly different from the control groups, but still in a safety level. A dose of 800 mg kg −1 day −1 was identified as the no observed adverse effect level ( NOAEL ) in this study. The body weight of SD rats treated orally with cocoa green tea water extract for 28 days. Nutzungsrecht: © 2015 Institute of Food Science and Technology natural decaffeinated tea subacute toxicity Green cocoa tea water extract Toxicity Food science Tea Rodents Zhou, Xuelin oth Yang, Xiaorong oth Shi, Xianggang oth Song, Xiaohong oth Ye, Chuangxing oth Ko, Chun Hay oth Enthalten in International journal of food science & technology Oxford : Blackwell, 1987 50(2015), 11, Seite 2391-2401 (DE-627)130679712 (DE-600)883561-5 (DE-576)016221885 0950-5423 nnns volume:50 year:2015 number:11 pages:2391-2401 http://dx.doi.org/10.1111/ijfs.12905 Volltext http://onlinelibrary.wiley.com/doi/10.1111/ijfs.12905/abstract http://search.proquest.com/docview/1721587675 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_4219 AR 50 2015 11 2391-2401 |
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10.1111/ijfs.12905 doi PQ20160617 (DE-627)OLC1965115322 (DE-599)GBVOLC1965115322 (PRQ)c1885-1ac23f4f89892a82889eef4d12f43b4a8e13a11099b4bbbb41f2ddb40ef406440 (KEY)0040074220150000050001102391subacuteoraltoxicityofcocoateacamelliaptilophyllaw DE-627 ger DE-627 rakwb eng 630 640 610 660 DNB Li, Kaikai verfasserin aut Subacute oral toxicity of cocoa tea (Camellia ptilophylla) water extract in SD rats 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Camellia ptilophylla , known as cocoa tea, is a natural decaffeinated tea plant which has been proved with potential bioactivities. This study was carried out to evaluate the safety of green cocoa tea water extract ( CWE ) by determining its potential toxicity after subacute administration in SD rats. In the subacute toxicity study, oral administration of CWE up to 800 mg kg −1 body weight day −1 for twenty‐eight consecutive days did not cause either mortality or toxicity in SD rats, regardless of gender. There were no adverse effects in body weight, food consumption, relative organ weight, haematological parameters, clinical chemistry, gross pathology and histopathology between treatment and control groups. Several parameters (e.g. neutrophils%, Ca 2+ , total Ca) in CWE ‐treated rats with high dosage were significantly different from the control groups, but still in a safety level. A dose of 800 mg kg −1 day −1 was identified as the no observed adverse effect level ( NOAEL ) in this study. The body weight of SD rats treated orally with cocoa green tea water extract for 28 days. Nutzungsrecht: © 2015 Institute of Food Science and Technology natural decaffeinated tea subacute toxicity Green cocoa tea water extract Toxicity Food science Tea Rodents Zhou, Xuelin oth Yang, Xiaorong oth Shi, Xianggang oth Song, Xiaohong oth Ye, Chuangxing oth Ko, Chun Hay oth Enthalten in International journal of food science & technology Oxford : Blackwell, 1987 50(2015), 11, Seite 2391-2401 (DE-627)130679712 (DE-600)883561-5 (DE-576)016221885 0950-5423 nnns volume:50 year:2015 number:11 pages:2391-2401 http://dx.doi.org/10.1111/ijfs.12905 Volltext http://onlinelibrary.wiley.com/doi/10.1111/ijfs.12905/abstract http://search.proquest.com/docview/1721587675 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_4219 AR 50 2015 11 2391-2401 |
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10.1111/ijfs.12905 doi PQ20160617 (DE-627)OLC1965115322 (DE-599)GBVOLC1965115322 (PRQ)c1885-1ac23f4f89892a82889eef4d12f43b4a8e13a11099b4bbbb41f2ddb40ef406440 (KEY)0040074220150000050001102391subacuteoraltoxicityofcocoateacamelliaptilophyllaw DE-627 ger DE-627 rakwb eng 630 640 610 660 DNB Li, Kaikai verfasserin aut Subacute oral toxicity of cocoa tea (Camellia ptilophylla) water extract in SD rats 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Camellia ptilophylla , known as cocoa tea, is a natural decaffeinated tea plant which has been proved with potential bioactivities. This study was carried out to evaluate the safety of green cocoa tea water extract ( CWE ) by determining its potential toxicity after subacute administration in SD rats. In the subacute toxicity study, oral administration of CWE up to 800 mg kg −1 body weight day −1 for twenty‐eight consecutive days did not cause either mortality or toxicity in SD rats, regardless of gender. There were no adverse effects in body weight, food consumption, relative organ weight, haematological parameters, clinical chemistry, gross pathology and histopathology between treatment and control groups. Several parameters (e.g. neutrophils%, Ca 2+ , total Ca) in CWE ‐treated rats with high dosage were significantly different from the control groups, but still in a safety level. A dose of 800 mg kg −1 day −1 was identified as the no observed adverse effect level ( NOAEL ) in this study. The body weight of SD rats treated orally with cocoa green tea water extract for 28 days. Nutzungsrecht: © 2015 Institute of Food Science and Technology natural decaffeinated tea subacute toxicity Green cocoa tea water extract Toxicity Food science Tea Rodents Zhou, Xuelin oth Yang, Xiaorong oth Shi, Xianggang oth Song, Xiaohong oth Ye, Chuangxing oth Ko, Chun Hay oth Enthalten in International journal of food science & technology Oxford : Blackwell, 1987 50(2015), 11, Seite 2391-2401 (DE-627)130679712 (DE-600)883561-5 (DE-576)016221885 0950-5423 nnns volume:50 year:2015 number:11 pages:2391-2401 http://dx.doi.org/10.1111/ijfs.12905 Volltext http://onlinelibrary.wiley.com/doi/10.1111/ijfs.12905/abstract http://search.proquest.com/docview/1721587675 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_4219 AR 50 2015 11 2391-2401 |
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10.1111/ijfs.12905 doi PQ20160617 (DE-627)OLC1965115322 (DE-599)GBVOLC1965115322 (PRQ)c1885-1ac23f4f89892a82889eef4d12f43b4a8e13a11099b4bbbb41f2ddb40ef406440 (KEY)0040074220150000050001102391subacuteoraltoxicityofcocoateacamelliaptilophyllaw DE-627 ger DE-627 rakwb eng 630 640 610 660 DNB Li, Kaikai verfasserin aut Subacute oral toxicity of cocoa tea (Camellia ptilophylla) water extract in SD rats 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Camellia ptilophylla , known as cocoa tea, is a natural decaffeinated tea plant which has been proved with potential bioactivities. This study was carried out to evaluate the safety of green cocoa tea water extract ( CWE ) by determining its potential toxicity after subacute administration in SD rats. In the subacute toxicity study, oral administration of CWE up to 800 mg kg −1 body weight day −1 for twenty‐eight consecutive days did not cause either mortality or toxicity in SD rats, regardless of gender. There were no adverse effects in body weight, food consumption, relative organ weight, haematological parameters, clinical chemistry, gross pathology and histopathology between treatment and control groups. Several parameters (e.g. neutrophils%, Ca 2+ , total Ca) in CWE ‐treated rats with high dosage were significantly different from the control groups, but still in a safety level. A dose of 800 mg kg −1 day −1 was identified as the no observed adverse effect level ( NOAEL ) in this study. The body weight of SD rats treated orally with cocoa green tea water extract for 28 days. Nutzungsrecht: © 2015 Institute of Food Science and Technology natural decaffeinated tea subacute toxicity Green cocoa tea water extract Toxicity Food science Tea Rodents Zhou, Xuelin oth Yang, Xiaorong oth Shi, Xianggang oth Song, Xiaohong oth Ye, Chuangxing oth Ko, Chun Hay oth Enthalten in International journal of food science & technology Oxford : Blackwell, 1987 50(2015), 11, Seite 2391-2401 (DE-627)130679712 (DE-600)883561-5 (DE-576)016221885 0950-5423 nnns volume:50 year:2015 number:11 pages:2391-2401 http://dx.doi.org/10.1111/ijfs.12905 Volltext http://onlinelibrary.wiley.com/doi/10.1111/ijfs.12905/abstract http://search.proquest.com/docview/1721587675 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_4219 AR 50 2015 11 2391-2401 |
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Subacute oral toxicity of cocoa tea (Camellia ptilophylla) water extract in SD rats |
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Camellia ptilophylla , known as cocoa tea, is a natural decaffeinated tea plant which has been proved with potential bioactivities. This study was carried out to evaluate the safety of green cocoa tea water extract ( CWE ) by determining its potential toxicity after subacute administration in SD rats. In the subacute toxicity study, oral administration of CWE up to 800 mg kg −1 body weight day −1 for twenty‐eight consecutive days did not cause either mortality or toxicity in SD rats, regardless of gender. There were no adverse effects in body weight, food consumption, relative organ weight, haematological parameters, clinical chemistry, gross pathology and histopathology between treatment and control groups. Several parameters (e.g. neutrophils%, Ca 2+ , total Ca) in CWE ‐treated rats with high dosage were significantly different from the control groups, but still in a safety level. A dose of 800 mg kg −1 day −1 was identified as the no observed adverse effect level ( NOAEL ) in this study. The body weight of SD rats treated orally with cocoa green tea water extract for 28 days. |
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Camellia ptilophylla , known as cocoa tea, is a natural decaffeinated tea plant which has been proved with potential bioactivities. This study was carried out to evaluate the safety of green cocoa tea water extract ( CWE ) by determining its potential toxicity after subacute administration in SD rats. In the subacute toxicity study, oral administration of CWE up to 800 mg kg −1 body weight day −1 for twenty‐eight consecutive days did not cause either mortality or toxicity in SD rats, regardless of gender. There were no adverse effects in body weight, food consumption, relative organ weight, haematological parameters, clinical chemistry, gross pathology and histopathology between treatment and control groups. Several parameters (e.g. neutrophils%, Ca 2+ , total Ca) in CWE ‐treated rats with high dosage were significantly different from the control groups, but still in a safety level. A dose of 800 mg kg −1 day −1 was identified as the no observed adverse effect level ( NOAEL ) in this study. The body weight of SD rats treated orally with cocoa green tea water extract for 28 days. |
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Camellia ptilophylla , known as cocoa tea, is a natural decaffeinated tea plant which has been proved with potential bioactivities. This study was carried out to evaluate the safety of green cocoa tea water extract ( CWE ) by determining its potential toxicity after subacute administration in SD rats. In the subacute toxicity study, oral administration of CWE up to 800 mg kg −1 body weight day −1 for twenty‐eight consecutive days did not cause either mortality or toxicity in SD rats, regardless of gender. There were no adverse effects in body weight, food consumption, relative organ weight, haematological parameters, clinical chemistry, gross pathology and histopathology between treatment and control groups. Several parameters (e.g. neutrophils%, Ca 2+ , total Ca) in CWE ‐treated rats with high dosage were significantly different from the control groups, but still in a safety level. A dose of 800 mg kg −1 day −1 was identified as the no observed adverse effect level ( NOAEL ) in this study. The body weight of SD rats treated orally with cocoa green tea water extract for 28 days. |
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Subacute oral toxicity of cocoa tea (Camellia ptilophylla) water extract in SD rats |
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Zhou, Xuelin Yang, Xiaorong Shi, Xianggang Song, Xiaohong Ye, Chuangxing Ko, Chun Hay |
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