Loss of Sprouty2 in human high‐grade serous ovarian carcinomas promotes EGF‐induced E‐cadherin down‐regulation and cell invasion
Sprouty (SPRY) proteins are well‐characterized factors that inhibit receptor tyrosine kinase signaling. Our Human Exonic Evidence‐Based Oligonucleotide (HEEBO) microarray results showed that the mRNA levels of SPRY2, but not of SPRY1 or SPRY4, are down‐regulated in high‐grade serous ovarian carcinom...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
So, Wai-Kin [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Rechteinformationen: |
Nutzungsrecht: FEBS Letters 589 (2015) 1873-3468 © 2015 Federation of European Biochemical Societies Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
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| Übergeordnetes Werk: |
Enthalten in: FEBS letters - Amsterdam [u.a.] : Elsevier, 1968, 589(2015), 3, Seite 302-309 |
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| Übergeordnetes Werk: |
volume:589 ; year:2015 ; number:3 ; pages:302-309 |
| Links: |
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| DOI / URN: |
10.1016/j.febslet.2014.12.012 |
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OLC1965545629 |
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| 245 | 1 | 0 | |a Loss of Sprouty2 in human high‐grade serous ovarian carcinomas promotes EGF‐induced E‐cadherin down‐regulation and cell invasion |
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| 520 | |a Sprouty (SPRY) proteins are well‐characterized factors that inhibit receptor tyrosine kinase signaling. Our Human Exonic Evidence‐Based Oligonucleotide (HEEBO) microarray results showed that the mRNA levels of SPRY2, but not of SPRY1 or SPRY4, are down‐regulated in high‐grade serous ovarian carcinoma (HGSC) tissues and epithelial ovarian cancer (EOC) cell lines. Molecular inversion probe (MIP) copy number analysis showed the deletion of the SPRY2 locus in HGSC. Overexpression of SPRY2 reduced EGF‐induced cell invasion by attenuating EGF‐induced E‐cadherin down‐regulation. Moreover, a positive correlation between SPRY2 and E‐cadherin protein levels was observed in HGSC tissues. This study reveals the loss of SPRY2 in HGSC and indicates an important tumor‐suppressive role for SPRY2 in mediating the stimulatory effect of EGF on human EOC progression. SPRY2 is down‐regulated in high‐grade serous ovarian carcinomas. SPRY2 gene is deleted in high‐grade serous ovarian carcinomas. Overexpression of SPRY2 attenuates EGF‐induced down‐regulation of E‐cadherin. Overexpression of SPRY2 attenuates EGF‐induced cell invasion. | ||
| 540 | |a Nutzungsrecht: FEBS Letters 589 (2015) 1873-3468 © 2015 Federation of European Biochemical Societies | ||
| 540 | |a Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. | ||
| 650 | 4 | |a Invasion | |
| 650 | 4 | |a Ovarian cancer | |
| 650 | 4 | |a Epidermal growth factor | |
| 650 | 4 | |a Sprouty | |
| 650 | 4 | |a E-cadherin | |
| 650 | 4 | |a Cadherins - biosynthesis | |
| 650 | 4 | |a Neoplasms, Glandular and Epithelial - genetics | |
| 650 | 4 | |a Carcinoma - genetics | |
| 650 | 4 | |a Intracellular Signaling Peptides and Proteins - genetics | |
| 650 | 4 | |a Membrane Proteins - genetics | |
| 650 | 4 | |a Ovarian Neoplasms - pathology | |
| 650 | 4 | |a Cadherins - genetics | |
| 650 | 4 | |a Carcinoma - pathology | |
| 650 | 4 | |a Epidermal Growth Factor - genetics | |
| 650 | 4 | |a Neoplasms, Glandular and Epithelial - pathology | |
| 650 | 4 | |a Epidermal Growth Factor - metabolism | |
| 650 | 4 | |a Ovarian Neoplasms - genetics | |
| 650 | 4 | |a Signal Transduction - genetics | |
| 700 | 1 | |a Cheng, Jung-Chien |4 oth | |
| 700 | 1 | |a Fan, Qianlan |4 oth | |
| 700 | 1 | |a Wong, Alice S.T |4 oth | |
| 700 | 1 | |a Huntsman, David G |4 oth | |
| 700 | 1 | |a Gilks, C. Blake |4 oth | |
| 700 | 1 | |a Leung, Peter C.K |4 oth | |
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10.1016/j.febslet.2014.12.012 doi PQ20160617 (DE-627)OLC1965545629 (DE-599)GBVOLC1965545629 (PRQ)c1948-86e4c5f4fa89542db42bd65cd94207ce1edf9fe0784a8f43a11fc09a77cf3aa30 (KEY)0045922420150000589000300302lossofsprouty2inhumanhighgradeserousovariancarcino DE-627 ger DE-627 rakwb eng 570 530 610 DNB So, Wai-Kin verfasserin aut Loss of Sprouty2 in human high‐grade serous ovarian carcinomas promotes EGF‐induced E‐cadherin down‐regulation and cell invasion 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Sprouty (SPRY) proteins are well‐characterized factors that inhibit receptor tyrosine kinase signaling. Our Human Exonic Evidence‐Based Oligonucleotide (HEEBO) microarray results showed that the mRNA levels of SPRY2, but not of SPRY1 or SPRY4, are down‐regulated in high‐grade serous ovarian carcinoma (HGSC) tissues and epithelial ovarian cancer (EOC) cell lines. Molecular inversion probe (MIP) copy number analysis showed the deletion of the SPRY2 locus in HGSC. Overexpression of SPRY2 reduced EGF‐induced cell invasion by attenuating EGF‐induced E‐cadherin down‐regulation. Moreover, a positive correlation between SPRY2 and E‐cadherin protein levels was observed in HGSC tissues. This study reveals the loss of SPRY2 in HGSC and indicates an important tumor‐suppressive role for SPRY2 in mediating the stimulatory effect of EGF on human EOC progression. SPRY2 is down‐regulated in high‐grade serous ovarian carcinomas. SPRY2 gene is deleted in high‐grade serous ovarian carcinomas. Overexpression of SPRY2 attenuates EGF‐induced down‐regulation of E‐cadherin. Overexpression of SPRY2 attenuates EGF‐induced cell invasion. Nutzungsrecht: FEBS Letters 589 (2015) 1873-3468 © 2015 Federation of European Biochemical Societies Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. Invasion Ovarian cancer Epidermal growth factor Sprouty E-cadherin Cadherins - biosynthesis Neoplasms, Glandular and Epithelial - genetics Carcinoma - genetics Intracellular Signaling Peptides and Proteins - genetics Membrane Proteins - genetics Ovarian Neoplasms - pathology Cadherins - genetics Carcinoma - pathology Epidermal Growth Factor - genetics Neoplasms, Glandular and Epithelial - pathology Epidermal Growth Factor - metabolism Ovarian Neoplasms - genetics Signal Transduction - genetics Cheng, Jung-Chien oth Fan, Qianlan oth Wong, Alice S.T oth Huntsman, David G oth Gilks, C. Blake oth Leung, Peter C.K oth Enthalten in FEBS letters Amsterdam [u.a.] : Elsevier, 1968 589(2015), 3, Seite 302-309 (DE-627)129522023 (DE-600)212746-5 (DE-576)014938014 0014-5793 nnns volume:589 year:2015 number:3 pages:302-309 http://dx.doi.org/10.1016/j.febslet.2014.12.012 Volltext http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2014.12.012/abstract http://www.ncbi.nlm.nih.gov/pubmed/25533808 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_70 GBV_ILN_211 GBV_ILN_2219 GBV_ILN_4012 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 AR 589 2015 3 302-309 |
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10.1016/j.febslet.2014.12.012 doi PQ20160617 (DE-627)OLC1965545629 (DE-599)GBVOLC1965545629 (PRQ)c1948-86e4c5f4fa89542db42bd65cd94207ce1edf9fe0784a8f43a11fc09a77cf3aa30 (KEY)0045922420150000589000300302lossofsprouty2inhumanhighgradeserousovariancarcino DE-627 ger DE-627 rakwb eng 570 530 610 DNB So, Wai-Kin verfasserin aut Loss of Sprouty2 in human high‐grade serous ovarian carcinomas promotes EGF‐induced E‐cadherin down‐regulation and cell invasion 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Sprouty (SPRY) proteins are well‐characterized factors that inhibit receptor tyrosine kinase signaling. Our Human Exonic Evidence‐Based Oligonucleotide (HEEBO) microarray results showed that the mRNA levels of SPRY2, but not of SPRY1 or SPRY4, are down‐regulated in high‐grade serous ovarian carcinoma (HGSC) tissues and epithelial ovarian cancer (EOC) cell lines. Molecular inversion probe (MIP) copy number analysis showed the deletion of the SPRY2 locus in HGSC. Overexpression of SPRY2 reduced EGF‐induced cell invasion by attenuating EGF‐induced E‐cadherin down‐regulation. Moreover, a positive correlation between SPRY2 and E‐cadherin protein levels was observed in HGSC tissues. This study reveals the loss of SPRY2 in HGSC and indicates an important tumor‐suppressive role for SPRY2 in mediating the stimulatory effect of EGF on human EOC progression. SPRY2 is down‐regulated in high‐grade serous ovarian carcinomas. SPRY2 gene is deleted in high‐grade serous ovarian carcinomas. Overexpression of SPRY2 attenuates EGF‐induced down‐regulation of E‐cadherin. Overexpression of SPRY2 attenuates EGF‐induced cell invasion. Nutzungsrecht: FEBS Letters 589 (2015) 1873-3468 © 2015 Federation of European Biochemical Societies Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. Invasion Ovarian cancer Epidermal growth factor Sprouty E-cadherin Cadherins - biosynthesis Neoplasms, Glandular and Epithelial - genetics Carcinoma - genetics Intracellular Signaling Peptides and Proteins - genetics Membrane Proteins - genetics Ovarian Neoplasms - pathology Cadherins - genetics Carcinoma - pathology Epidermal Growth Factor - genetics Neoplasms, Glandular and Epithelial - pathology Epidermal Growth Factor - metabolism Ovarian Neoplasms - genetics Signal Transduction - genetics Cheng, Jung-Chien oth Fan, Qianlan oth Wong, Alice S.T oth Huntsman, David G oth Gilks, C. Blake oth Leung, Peter C.K oth Enthalten in FEBS letters Amsterdam [u.a.] : Elsevier, 1968 589(2015), 3, Seite 302-309 (DE-627)129522023 (DE-600)212746-5 (DE-576)014938014 0014-5793 nnns volume:589 year:2015 number:3 pages:302-309 http://dx.doi.org/10.1016/j.febslet.2014.12.012 Volltext http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2014.12.012/abstract http://www.ncbi.nlm.nih.gov/pubmed/25533808 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_70 GBV_ILN_211 GBV_ILN_2219 GBV_ILN_4012 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 AR 589 2015 3 302-309 |
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10.1016/j.febslet.2014.12.012 doi PQ20160617 (DE-627)OLC1965545629 (DE-599)GBVOLC1965545629 (PRQ)c1948-86e4c5f4fa89542db42bd65cd94207ce1edf9fe0784a8f43a11fc09a77cf3aa30 (KEY)0045922420150000589000300302lossofsprouty2inhumanhighgradeserousovariancarcino DE-627 ger DE-627 rakwb eng 570 530 610 DNB So, Wai-Kin verfasserin aut Loss of Sprouty2 in human high‐grade serous ovarian carcinomas promotes EGF‐induced E‐cadherin down‐regulation and cell invasion 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Sprouty (SPRY) proteins are well‐characterized factors that inhibit receptor tyrosine kinase signaling. Our Human Exonic Evidence‐Based Oligonucleotide (HEEBO) microarray results showed that the mRNA levels of SPRY2, but not of SPRY1 or SPRY4, are down‐regulated in high‐grade serous ovarian carcinoma (HGSC) tissues and epithelial ovarian cancer (EOC) cell lines. Molecular inversion probe (MIP) copy number analysis showed the deletion of the SPRY2 locus in HGSC. Overexpression of SPRY2 reduced EGF‐induced cell invasion by attenuating EGF‐induced E‐cadherin down‐regulation. Moreover, a positive correlation between SPRY2 and E‐cadherin protein levels was observed in HGSC tissues. This study reveals the loss of SPRY2 in HGSC and indicates an important tumor‐suppressive role for SPRY2 in mediating the stimulatory effect of EGF on human EOC progression. SPRY2 is down‐regulated in high‐grade serous ovarian carcinomas. SPRY2 gene is deleted in high‐grade serous ovarian carcinomas. Overexpression of SPRY2 attenuates EGF‐induced down‐regulation of E‐cadherin. Overexpression of SPRY2 attenuates EGF‐induced cell invasion. Nutzungsrecht: FEBS Letters 589 (2015) 1873-3468 © 2015 Federation of European Biochemical Societies Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. Invasion Ovarian cancer Epidermal growth factor Sprouty E-cadherin Cadherins - biosynthesis Neoplasms, Glandular and Epithelial - genetics Carcinoma - genetics Intracellular Signaling Peptides and Proteins - genetics Membrane Proteins - genetics Ovarian Neoplasms - pathology Cadherins - genetics Carcinoma - pathology Epidermal Growth Factor - genetics Neoplasms, Glandular and Epithelial - pathology Epidermal Growth Factor - metabolism Ovarian Neoplasms - genetics Signal Transduction - genetics Cheng, Jung-Chien oth Fan, Qianlan oth Wong, Alice S.T oth Huntsman, David G oth Gilks, C. Blake oth Leung, Peter C.K oth Enthalten in FEBS letters Amsterdam [u.a.] : Elsevier, 1968 589(2015), 3, Seite 302-309 (DE-627)129522023 (DE-600)212746-5 (DE-576)014938014 0014-5793 nnns volume:589 year:2015 number:3 pages:302-309 http://dx.doi.org/10.1016/j.febslet.2014.12.012 Volltext http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2014.12.012/abstract http://www.ncbi.nlm.nih.gov/pubmed/25533808 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_70 GBV_ILN_211 GBV_ILN_2219 GBV_ILN_4012 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 AR 589 2015 3 302-309 |
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10.1016/j.febslet.2014.12.012 doi PQ20160617 (DE-627)OLC1965545629 (DE-599)GBVOLC1965545629 (PRQ)c1948-86e4c5f4fa89542db42bd65cd94207ce1edf9fe0784a8f43a11fc09a77cf3aa30 (KEY)0045922420150000589000300302lossofsprouty2inhumanhighgradeserousovariancarcino DE-627 ger DE-627 rakwb eng 570 530 610 DNB So, Wai-Kin verfasserin aut Loss of Sprouty2 in human high‐grade serous ovarian carcinomas promotes EGF‐induced E‐cadherin down‐regulation and cell invasion 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Sprouty (SPRY) proteins are well‐characterized factors that inhibit receptor tyrosine kinase signaling. Our Human Exonic Evidence‐Based Oligonucleotide (HEEBO) microarray results showed that the mRNA levels of SPRY2, but not of SPRY1 or SPRY4, are down‐regulated in high‐grade serous ovarian carcinoma (HGSC) tissues and epithelial ovarian cancer (EOC) cell lines. Molecular inversion probe (MIP) copy number analysis showed the deletion of the SPRY2 locus in HGSC. Overexpression of SPRY2 reduced EGF‐induced cell invasion by attenuating EGF‐induced E‐cadherin down‐regulation. Moreover, a positive correlation between SPRY2 and E‐cadherin protein levels was observed in HGSC tissues. This study reveals the loss of SPRY2 in HGSC and indicates an important tumor‐suppressive role for SPRY2 in mediating the stimulatory effect of EGF on human EOC progression. SPRY2 is down‐regulated in high‐grade serous ovarian carcinomas. SPRY2 gene is deleted in high‐grade serous ovarian carcinomas. Overexpression of SPRY2 attenuates EGF‐induced down‐regulation of E‐cadherin. Overexpression of SPRY2 attenuates EGF‐induced cell invasion. Nutzungsrecht: FEBS Letters 589 (2015) 1873-3468 © 2015 Federation of European Biochemical Societies Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. Invasion Ovarian cancer Epidermal growth factor Sprouty E-cadherin Cadherins - biosynthesis Neoplasms, Glandular and Epithelial - genetics Carcinoma - genetics Intracellular Signaling Peptides and Proteins - genetics Membrane Proteins - genetics Ovarian Neoplasms - pathology Cadherins - genetics Carcinoma - pathology Epidermal Growth Factor - genetics Neoplasms, Glandular and Epithelial - pathology Epidermal Growth Factor - metabolism Ovarian Neoplasms - genetics Signal Transduction - genetics Cheng, Jung-Chien oth Fan, Qianlan oth Wong, Alice S.T oth Huntsman, David G oth Gilks, C. Blake oth Leung, Peter C.K oth Enthalten in FEBS letters Amsterdam [u.a.] : Elsevier, 1968 589(2015), 3, Seite 302-309 (DE-627)129522023 (DE-600)212746-5 (DE-576)014938014 0014-5793 nnns volume:589 year:2015 number:3 pages:302-309 http://dx.doi.org/10.1016/j.febslet.2014.12.012 Volltext http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2014.12.012/abstract http://www.ncbi.nlm.nih.gov/pubmed/25533808 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_70 GBV_ILN_211 GBV_ILN_2219 GBV_ILN_4012 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 AR 589 2015 3 302-309 |
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10.1016/j.febslet.2014.12.012 doi PQ20160617 (DE-627)OLC1965545629 (DE-599)GBVOLC1965545629 (PRQ)c1948-86e4c5f4fa89542db42bd65cd94207ce1edf9fe0784a8f43a11fc09a77cf3aa30 (KEY)0045922420150000589000300302lossofsprouty2inhumanhighgradeserousovariancarcino DE-627 ger DE-627 rakwb eng 570 530 610 DNB So, Wai-Kin verfasserin aut Loss of Sprouty2 in human high‐grade serous ovarian carcinomas promotes EGF‐induced E‐cadherin down‐regulation and cell invasion 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Sprouty (SPRY) proteins are well‐characterized factors that inhibit receptor tyrosine kinase signaling. Our Human Exonic Evidence‐Based Oligonucleotide (HEEBO) microarray results showed that the mRNA levels of SPRY2, but not of SPRY1 or SPRY4, are down‐regulated in high‐grade serous ovarian carcinoma (HGSC) tissues and epithelial ovarian cancer (EOC) cell lines. Molecular inversion probe (MIP) copy number analysis showed the deletion of the SPRY2 locus in HGSC. Overexpression of SPRY2 reduced EGF‐induced cell invasion by attenuating EGF‐induced E‐cadherin down‐regulation. Moreover, a positive correlation between SPRY2 and E‐cadherin protein levels was observed in HGSC tissues. This study reveals the loss of SPRY2 in HGSC and indicates an important tumor‐suppressive role for SPRY2 in mediating the stimulatory effect of EGF on human EOC progression. SPRY2 is down‐regulated in high‐grade serous ovarian carcinomas. SPRY2 gene is deleted in high‐grade serous ovarian carcinomas. Overexpression of SPRY2 attenuates EGF‐induced down‐regulation of E‐cadherin. Overexpression of SPRY2 attenuates EGF‐induced cell invasion. Nutzungsrecht: FEBS Letters 589 (2015) 1873-3468 © 2015 Federation of European Biochemical Societies Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. Invasion Ovarian cancer Epidermal growth factor Sprouty E-cadherin Cadherins - biosynthesis Neoplasms, Glandular and Epithelial - genetics Carcinoma - genetics Intracellular Signaling Peptides and Proteins - genetics Membrane Proteins - genetics Ovarian Neoplasms - pathology Cadherins - genetics Carcinoma - pathology Epidermal Growth Factor - genetics Neoplasms, Glandular and Epithelial - pathology Epidermal Growth Factor - metabolism Ovarian Neoplasms - genetics Signal Transduction - genetics Cheng, Jung-Chien oth Fan, Qianlan oth Wong, Alice S.T oth Huntsman, David G oth Gilks, C. Blake oth Leung, Peter C.K oth Enthalten in FEBS letters Amsterdam [u.a.] : Elsevier, 1968 589(2015), 3, Seite 302-309 (DE-627)129522023 (DE-600)212746-5 (DE-576)014938014 0014-5793 nnns volume:589 year:2015 number:3 pages:302-309 http://dx.doi.org/10.1016/j.febslet.2014.12.012 Volltext http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2014.12.012/abstract http://www.ncbi.nlm.nih.gov/pubmed/25533808 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_70 GBV_ILN_211 GBV_ILN_2219 GBV_ILN_4012 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 AR 589 2015 3 302-309 |
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So, Wai-Kin ddc 570 misc Invasion misc Ovarian cancer misc Epidermal growth factor misc Sprouty misc E-cadherin misc Cadherins - biosynthesis misc Neoplasms, Glandular and Epithelial - genetics misc Carcinoma - genetics misc Intracellular Signaling Peptides and Proteins - genetics misc Membrane Proteins - genetics misc Ovarian Neoplasms - pathology misc Cadherins - genetics misc Carcinoma - pathology misc Epidermal Growth Factor - genetics misc Neoplasms, Glandular and Epithelial - pathology misc Epidermal Growth Factor - metabolism misc Ovarian Neoplasms - genetics misc Signal Transduction - genetics Loss of Sprouty2 in human high‐grade serous ovarian carcinomas promotes EGF‐induced E‐cadherin down‐regulation and cell invasion |
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570 530 610 DNB Loss of Sprouty2 in human high‐grade serous ovarian carcinomas promotes EGF‐induced E‐cadherin down‐regulation and cell invasion Invasion Ovarian cancer Epidermal growth factor Sprouty E-cadherin Cadherins - biosynthesis Neoplasms, Glandular and Epithelial - genetics Carcinoma - genetics Intracellular Signaling Peptides and Proteins - genetics Membrane Proteins - genetics Ovarian Neoplasms - pathology Cadherins - genetics Carcinoma - pathology Epidermal Growth Factor - genetics Neoplasms, Glandular and Epithelial - pathology Epidermal Growth Factor - metabolism Ovarian Neoplasms - genetics Signal Transduction - genetics |
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loss of sprouty2 in human high‐grade serous ovarian carcinomas promotes egf‐induced e‐cadherin down‐regulation and cell invasion |
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Loss of Sprouty2 in human high‐grade serous ovarian carcinomas promotes EGF‐induced E‐cadherin down‐regulation and cell invasion |
| abstract |
Sprouty (SPRY) proteins are well‐characterized factors that inhibit receptor tyrosine kinase signaling. Our Human Exonic Evidence‐Based Oligonucleotide (HEEBO) microarray results showed that the mRNA levels of SPRY2, but not of SPRY1 or SPRY4, are down‐regulated in high‐grade serous ovarian carcinoma (HGSC) tissues and epithelial ovarian cancer (EOC) cell lines. Molecular inversion probe (MIP) copy number analysis showed the deletion of the SPRY2 locus in HGSC. Overexpression of SPRY2 reduced EGF‐induced cell invasion by attenuating EGF‐induced E‐cadherin down‐regulation. Moreover, a positive correlation between SPRY2 and E‐cadherin protein levels was observed in HGSC tissues. This study reveals the loss of SPRY2 in HGSC and indicates an important tumor‐suppressive role for SPRY2 in mediating the stimulatory effect of EGF on human EOC progression. SPRY2 is down‐regulated in high‐grade serous ovarian carcinomas. SPRY2 gene is deleted in high‐grade serous ovarian carcinomas. Overexpression of SPRY2 attenuates EGF‐induced down‐regulation of E‐cadherin. Overexpression of SPRY2 attenuates EGF‐induced cell invasion. |
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Sprouty (SPRY) proteins are well‐characterized factors that inhibit receptor tyrosine kinase signaling. Our Human Exonic Evidence‐Based Oligonucleotide (HEEBO) microarray results showed that the mRNA levels of SPRY2, but not of SPRY1 or SPRY4, are down‐regulated in high‐grade serous ovarian carcinoma (HGSC) tissues and epithelial ovarian cancer (EOC) cell lines. Molecular inversion probe (MIP) copy number analysis showed the deletion of the SPRY2 locus in HGSC. Overexpression of SPRY2 reduced EGF‐induced cell invasion by attenuating EGF‐induced E‐cadherin down‐regulation. Moreover, a positive correlation between SPRY2 and E‐cadherin protein levels was observed in HGSC tissues. This study reveals the loss of SPRY2 in HGSC and indicates an important tumor‐suppressive role for SPRY2 in mediating the stimulatory effect of EGF on human EOC progression. SPRY2 is down‐regulated in high‐grade serous ovarian carcinomas. SPRY2 gene is deleted in high‐grade serous ovarian carcinomas. Overexpression of SPRY2 attenuates EGF‐induced down‐regulation of E‐cadherin. Overexpression of SPRY2 attenuates EGF‐induced cell invasion. |
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Sprouty (SPRY) proteins are well‐characterized factors that inhibit receptor tyrosine kinase signaling. Our Human Exonic Evidence‐Based Oligonucleotide (HEEBO) microarray results showed that the mRNA levels of SPRY2, but not of SPRY1 or SPRY4, are down‐regulated in high‐grade serous ovarian carcinoma (HGSC) tissues and epithelial ovarian cancer (EOC) cell lines. Molecular inversion probe (MIP) copy number analysis showed the deletion of the SPRY2 locus in HGSC. Overexpression of SPRY2 reduced EGF‐induced cell invasion by attenuating EGF‐induced E‐cadherin down‐regulation. Moreover, a positive correlation between SPRY2 and E‐cadherin protein levels was observed in HGSC tissues. This study reveals the loss of SPRY2 in HGSC and indicates an important tumor‐suppressive role for SPRY2 in mediating the stimulatory effect of EGF on human EOC progression. SPRY2 is down‐regulated in high‐grade serous ovarian carcinomas. SPRY2 gene is deleted in high‐grade serous ovarian carcinomas. Overexpression of SPRY2 attenuates EGF‐induced down‐regulation of E‐cadherin. Overexpression of SPRY2 attenuates EGF‐induced cell invasion. |
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Loss of Sprouty2 in human high‐grade serous ovarian carcinomas promotes EGF‐induced E‐cadherin down‐regulation and cell invasion |
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Our Human Exonic Evidence‐Based Oligonucleotide (HEEBO) microarray results showed that the mRNA levels of SPRY2, but not of SPRY1 or SPRY4, are down‐regulated in high‐grade serous ovarian carcinoma (HGSC) tissues and epithelial ovarian cancer (EOC) cell lines. Molecular inversion probe (MIP) copy number analysis showed the deletion of the SPRY2 locus in HGSC. Overexpression of SPRY2 reduced EGF‐induced cell invasion by attenuating EGF‐induced E‐cadherin down‐regulation. Moreover, a positive correlation between SPRY2 and E‐cadherin protein levels was observed in HGSC tissues. This study reveals the loss of SPRY2 in HGSC and indicates an important tumor‐suppressive role for SPRY2 in mediating the stimulatory effect of EGF on human EOC progression. SPRY2 is down‐regulated in high‐grade serous ovarian carcinomas. SPRY2 gene is deleted in high‐grade serous ovarian carcinomas. Overexpression of SPRY2 attenuates EGF‐induced down‐regulation of E‐cadherin. Overexpression of SPRY2 attenuates EGF‐induced cell invasion.</subfield></datafield><datafield tag="540" ind1=" " ind2=" "><subfield code="a">Nutzungsrecht: FEBS Letters 589 (2015) 1873-3468 © 2015 Federation of European Biochemical Societies</subfield></datafield><datafield tag="540" ind1=" " ind2=" "><subfield code="a">Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Invasion</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Ovarian cancer</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Epidermal growth factor</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Sprouty</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">E-cadherin</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cadherins - biosynthesis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Neoplasms, Glandular and Epithelial - genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Carcinoma - genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Intracellular Signaling Peptides and Proteins - genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Membrane Proteins - genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Ovarian Neoplasms - pathology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cadherins - genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Carcinoma - pathology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Epidermal Growth Factor - genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Neoplasms, Glandular and Epithelial - pathology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Epidermal Growth Factor - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Ovarian Neoplasms - genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Signal Transduction - genetics</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cheng, Jung-Chien</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Fan, Qianlan</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wong, Alice S.T</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Huntsman, David G</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gilks, C. Blake</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Leung, Peter C.K</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">FEBS letters</subfield><subfield code="d">Amsterdam [u.a.] : Elsevier, 1968</subfield><subfield code="g">589(2015), 3, Seite 302-309</subfield><subfield code="w">(DE-627)129522023</subfield><subfield code="w">(DE-600)212746-5</subfield><subfield code="w">(DE-576)014938014</subfield><subfield code="x">0014-5793</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:589</subfield><subfield code="g">year:2015</subfield><subfield code="g">number:3</subfield><subfield code="g">pages:302-309</subfield></datafield><datafield tag="856" ind1="4" ind2="1"><subfield code="u">http://dx.doi.org/10.1016/j.febslet.2014.12.012</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2014.12.012/abstract</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">http://www.ncbi.nlm.nih.gov/pubmed/25533808</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_OLC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHY</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-CHE</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-DE-84</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_21</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_211</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2219</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4219</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">589</subfield><subfield code="j">2015</subfield><subfield code="e">3</subfield><subfield code="h">302-309</subfield></datafield></record></collection>
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