ZNF10 inhibits HIV‐1 LTR activity through interaction with NF‐κB and Sp1 binding motifs
Kruppel‐associated box‐containing zinc finger (KRAB‐ZNF) genes constitute the single largest gene family of transcriptional repressors in the genomes of higher organisms. In this study, we isolated 52 cDNA clones of KRAB‐ZFPs from U1 cell lines and screened them to identify which were capable of reg...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Nishitsuji, Hironori [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Rechteinformationen: |
Nutzungsrecht: FEBS Letters 589 (2015) 1873-3468 © 2015 Federation of European Biochemical Societies Copyright © 2015. Published by Elsevier B.V. |
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| Schlagwörter: |
Repressor Proteins - physiology Sp1 Transcription Factor - metabolism |
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| Übergeordnetes Werk: |
Enthalten in: FEBS letters - Amsterdam [u.a.] : Elsevier, 1968, 589(2015), 15, Seite 2019-2025 |
|---|---|
| Übergeordnetes Werk: |
volume:589 ; year:2015 ; number:15 ; pages:2019-2025 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.febslet.2015.06.013 |
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OLC1965548067 |
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| 520 | |a Kruppel‐associated box‐containing zinc finger (KRAB‐ZNF) genes constitute the single largest gene family of transcriptional repressors in the genomes of higher organisms. In this study, we isolated 52 cDNA clones of KRAB‐ZFPs from U1 cell lines and screened them to identify which were capable of regulating HIV‐1 gene expression. We identified 5 KRAB‐ZFPs that suppressed ⩾50% of HIV‐1 LTR. Of the 5 identified KRAB‐ZFPs, the expression of ZNF10 significantly enhanced the transcriptional repression activity of the LTR compared with other ZNFs. In addition, the depletion of endogenous ZNF10 led to the activation of HIV‐1 LTR. The repressor activity of ZNF10 was required for TRIM28, SETDB1 and HP1‐gamma binding. These results indicate that ZNF10 could be involved in a potent intrinsic antiretroviral defense. We isolated 52 cDNA clones of Kruppel‐related zinc finger genes from U1 cell lines. Over expression of ZNF10 represses HIV LTR‐mediated transcription to a greater extent than other ZNFs. The depletion of ZNF10 leads to the activation of HIV‐1 LTR. Repressor activity of ZNF10 is required for TRIM28, SETDB1, and HP1‐gamma, binding. | ||
| 540 | |a Nutzungsrecht: FEBS Letters 589 (2015) 1873-3468 © 2015 Federation of European Biochemical Societies | ||
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| 650 | 4 | |a NF-kappa B - metabolism | |
| 650 | 4 | |a HIV Long Terminal Repeat - physiology | |
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| 700 | 1 | |a Sugiyama, Ryuichi |4 oth | |
| 700 | 1 | |a Takaku, Hiroshi |4 oth | |
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10.1016/j.febslet.2015.06.013 doi PQ20160617 (DE-627)OLC1965548067 (DE-599)GBVOLC1965548067 (PRQ)c1946-20529e9f78a73417eeffea1519135ab8ea71489f94d3ab3ff041f778ee4266d20 (KEY)0045922420150000589001502019znf10inhibitshiv1ltractivitythroughinteractionwith DE-627 ger DE-627 rakwb eng 570 530 610 DNB Nishitsuji, Hironori verfasserin aut ZNF10 inhibits HIV‐1 LTR activity through interaction with NF‐κB and Sp1 binding motifs 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Kruppel‐associated box‐containing zinc finger (KRAB‐ZNF) genes constitute the single largest gene family of transcriptional repressors in the genomes of higher organisms. In this study, we isolated 52 cDNA clones of KRAB‐ZFPs from U1 cell lines and screened them to identify which were capable of regulating HIV‐1 gene expression. We identified 5 KRAB‐ZFPs that suppressed ⩾50% of HIV‐1 LTR. Of the 5 identified KRAB‐ZFPs, the expression of ZNF10 significantly enhanced the transcriptional repression activity of the LTR compared with other ZNFs. In addition, the depletion of endogenous ZNF10 led to the activation of HIV‐1 LTR. The repressor activity of ZNF10 was required for TRIM28, SETDB1 and HP1‐gamma binding. These results indicate that ZNF10 could be involved in a potent intrinsic antiretroviral defense. We isolated 52 cDNA clones of Kruppel‐related zinc finger genes from U1 cell lines. Over expression of ZNF10 represses HIV LTR‐mediated transcription to a greater extent than other ZNFs. The depletion of ZNF10 leads to the activation of HIV‐1 LTR. Repressor activity of ZNF10 is required for TRIM28, SETDB1, and HP1‐gamma, binding. Nutzungsrecht: FEBS Letters 589 (2015) 1873-3468 © 2015 Federation of European Biochemical Societies Copyright © 2015. Published by Elsevier B.V. SETDB1 HIV-1 LTR HP1-gamma KRAB domain Zinc finger protein TRIM28 Repressor Proteins - physiology Sp1 Transcription Factor - metabolism HIV-1 - genetics Kruppel-Like Transcription Factors - physiology NF-kappa B - metabolism HIV Long Terminal Repeat - physiology Sawada, Leila oth Sugiyama, Ryuichi oth Takaku, Hiroshi oth Enthalten in FEBS letters Amsterdam [u.a.] : Elsevier, 1968 589(2015), 15, Seite 2019-2025 (DE-627)129522023 (DE-600)212746-5 (DE-576)014938014 0014-5793 nnns volume:589 year:2015 number:15 pages:2019-2025 http://dx.doi.org/10.1016/j.febslet.2015.06.013 Volltext http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2015.06.013/abstract http://www.ncbi.nlm.nih.gov/pubmed/26096782 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_70 GBV_ILN_211 GBV_ILN_2219 GBV_ILN_4012 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 AR 589 2015 15 2019-2025 |
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10.1016/j.febslet.2015.06.013 doi PQ20160617 (DE-627)OLC1965548067 (DE-599)GBVOLC1965548067 (PRQ)c1946-20529e9f78a73417eeffea1519135ab8ea71489f94d3ab3ff041f778ee4266d20 (KEY)0045922420150000589001502019znf10inhibitshiv1ltractivitythroughinteractionwith DE-627 ger DE-627 rakwb eng 570 530 610 DNB Nishitsuji, Hironori verfasserin aut ZNF10 inhibits HIV‐1 LTR activity through interaction with NF‐κB and Sp1 binding motifs 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Kruppel‐associated box‐containing zinc finger (KRAB‐ZNF) genes constitute the single largest gene family of transcriptional repressors in the genomes of higher organisms. In this study, we isolated 52 cDNA clones of KRAB‐ZFPs from U1 cell lines and screened them to identify which were capable of regulating HIV‐1 gene expression. We identified 5 KRAB‐ZFPs that suppressed ⩾50% of HIV‐1 LTR. Of the 5 identified KRAB‐ZFPs, the expression of ZNF10 significantly enhanced the transcriptional repression activity of the LTR compared with other ZNFs. In addition, the depletion of endogenous ZNF10 led to the activation of HIV‐1 LTR. The repressor activity of ZNF10 was required for TRIM28, SETDB1 and HP1‐gamma binding. These results indicate that ZNF10 could be involved in a potent intrinsic antiretroviral defense. We isolated 52 cDNA clones of Kruppel‐related zinc finger genes from U1 cell lines. Over expression of ZNF10 represses HIV LTR‐mediated transcription to a greater extent than other ZNFs. The depletion of ZNF10 leads to the activation of HIV‐1 LTR. Repressor activity of ZNF10 is required for TRIM28, SETDB1, and HP1‐gamma, binding. Nutzungsrecht: FEBS Letters 589 (2015) 1873-3468 © 2015 Federation of European Biochemical Societies Copyright © 2015. Published by Elsevier B.V. SETDB1 HIV-1 LTR HP1-gamma KRAB domain Zinc finger protein TRIM28 Repressor Proteins - physiology Sp1 Transcription Factor - metabolism HIV-1 - genetics Kruppel-Like Transcription Factors - physiology NF-kappa B - metabolism HIV Long Terminal Repeat - physiology Sawada, Leila oth Sugiyama, Ryuichi oth Takaku, Hiroshi oth Enthalten in FEBS letters Amsterdam [u.a.] : Elsevier, 1968 589(2015), 15, Seite 2019-2025 (DE-627)129522023 (DE-600)212746-5 (DE-576)014938014 0014-5793 nnns volume:589 year:2015 number:15 pages:2019-2025 http://dx.doi.org/10.1016/j.febslet.2015.06.013 Volltext http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2015.06.013/abstract http://www.ncbi.nlm.nih.gov/pubmed/26096782 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_70 GBV_ILN_211 GBV_ILN_2219 GBV_ILN_4012 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 AR 589 2015 15 2019-2025 |
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10.1016/j.febslet.2015.06.013 doi PQ20160617 (DE-627)OLC1965548067 (DE-599)GBVOLC1965548067 (PRQ)c1946-20529e9f78a73417eeffea1519135ab8ea71489f94d3ab3ff041f778ee4266d20 (KEY)0045922420150000589001502019znf10inhibitshiv1ltractivitythroughinteractionwith DE-627 ger DE-627 rakwb eng 570 530 610 DNB Nishitsuji, Hironori verfasserin aut ZNF10 inhibits HIV‐1 LTR activity through interaction with NF‐κB and Sp1 binding motifs 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Kruppel‐associated box‐containing zinc finger (KRAB‐ZNF) genes constitute the single largest gene family of transcriptional repressors in the genomes of higher organisms. In this study, we isolated 52 cDNA clones of KRAB‐ZFPs from U1 cell lines and screened them to identify which were capable of regulating HIV‐1 gene expression. We identified 5 KRAB‐ZFPs that suppressed ⩾50% of HIV‐1 LTR. Of the 5 identified KRAB‐ZFPs, the expression of ZNF10 significantly enhanced the transcriptional repression activity of the LTR compared with other ZNFs. In addition, the depletion of endogenous ZNF10 led to the activation of HIV‐1 LTR. The repressor activity of ZNF10 was required for TRIM28, SETDB1 and HP1‐gamma binding. These results indicate that ZNF10 could be involved in a potent intrinsic antiretroviral defense. We isolated 52 cDNA clones of Kruppel‐related zinc finger genes from U1 cell lines. Over expression of ZNF10 represses HIV LTR‐mediated transcription to a greater extent than other ZNFs. The depletion of ZNF10 leads to the activation of HIV‐1 LTR. Repressor activity of ZNF10 is required for TRIM28, SETDB1, and HP1‐gamma, binding. Nutzungsrecht: FEBS Letters 589 (2015) 1873-3468 © 2015 Federation of European Biochemical Societies Copyright © 2015. Published by Elsevier B.V. SETDB1 HIV-1 LTR HP1-gamma KRAB domain Zinc finger protein TRIM28 Repressor Proteins - physiology Sp1 Transcription Factor - metabolism HIV-1 - genetics Kruppel-Like Transcription Factors - physiology NF-kappa B - metabolism HIV Long Terminal Repeat - physiology Sawada, Leila oth Sugiyama, Ryuichi oth Takaku, Hiroshi oth Enthalten in FEBS letters Amsterdam [u.a.] : Elsevier, 1968 589(2015), 15, Seite 2019-2025 (DE-627)129522023 (DE-600)212746-5 (DE-576)014938014 0014-5793 nnns volume:589 year:2015 number:15 pages:2019-2025 http://dx.doi.org/10.1016/j.febslet.2015.06.013 Volltext http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2015.06.013/abstract http://www.ncbi.nlm.nih.gov/pubmed/26096782 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_70 GBV_ILN_211 GBV_ILN_2219 GBV_ILN_4012 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 AR 589 2015 15 2019-2025 |
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10.1016/j.febslet.2015.06.013 doi PQ20160617 (DE-627)OLC1965548067 (DE-599)GBVOLC1965548067 (PRQ)c1946-20529e9f78a73417eeffea1519135ab8ea71489f94d3ab3ff041f778ee4266d20 (KEY)0045922420150000589001502019znf10inhibitshiv1ltractivitythroughinteractionwith DE-627 ger DE-627 rakwb eng 570 530 610 DNB Nishitsuji, Hironori verfasserin aut ZNF10 inhibits HIV‐1 LTR activity through interaction with NF‐κB and Sp1 binding motifs 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Kruppel‐associated box‐containing zinc finger (KRAB‐ZNF) genes constitute the single largest gene family of transcriptional repressors in the genomes of higher organisms. In this study, we isolated 52 cDNA clones of KRAB‐ZFPs from U1 cell lines and screened them to identify which were capable of regulating HIV‐1 gene expression. We identified 5 KRAB‐ZFPs that suppressed ⩾50% of HIV‐1 LTR. Of the 5 identified KRAB‐ZFPs, the expression of ZNF10 significantly enhanced the transcriptional repression activity of the LTR compared with other ZNFs. In addition, the depletion of endogenous ZNF10 led to the activation of HIV‐1 LTR. The repressor activity of ZNF10 was required for TRIM28, SETDB1 and HP1‐gamma binding. These results indicate that ZNF10 could be involved in a potent intrinsic antiretroviral defense. We isolated 52 cDNA clones of Kruppel‐related zinc finger genes from U1 cell lines. Over expression of ZNF10 represses HIV LTR‐mediated transcription to a greater extent than other ZNFs. The depletion of ZNF10 leads to the activation of HIV‐1 LTR. Repressor activity of ZNF10 is required for TRIM28, SETDB1, and HP1‐gamma, binding. Nutzungsrecht: FEBS Letters 589 (2015) 1873-3468 © 2015 Federation of European Biochemical Societies Copyright © 2015. Published by Elsevier B.V. SETDB1 HIV-1 LTR HP1-gamma KRAB domain Zinc finger protein TRIM28 Repressor Proteins - physiology Sp1 Transcription Factor - metabolism HIV-1 - genetics Kruppel-Like Transcription Factors - physiology NF-kappa B - metabolism HIV Long Terminal Repeat - physiology Sawada, Leila oth Sugiyama, Ryuichi oth Takaku, Hiroshi oth Enthalten in FEBS letters Amsterdam [u.a.] : Elsevier, 1968 589(2015), 15, Seite 2019-2025 (DE-627)129522023 (DE-600)212746-5 (DE-576)014938014 0014-5793 nnns volume:589 year:2015 number:15 pages:2019-2025 http://dx.doi.org/10.1016/j.febslet.2015.06.013 Volltext http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2015.06.013/abstract http://www.ncbi.nlm.nih.gov/pubmed/26096782 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_70 GBV_ILN_211 GBV_ILN_2219 GBV_ILN_4012 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 AR 589 2015 15 2019-2025 |
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10.1016/j.febslet.2015.06.013 doi PQ20160617 (DE-627)OLC1965548067 (DE-599)GBVOLC1965548067 (PRQ)c1946-20529e9f78a73417eeffea1519135ab8ea71489f94d3ab3ff041f778ee4266d20 (KEY)0045922420150000589001502019znf10inhibitshiv1ltractivitythroughinteractionwith DE-627 ger DE-627 rakwb eng 570 530 610 DNB Nishitsuji, Hironori verfasserin aut ZNF10 inhibits HIV‐1 LTR activity through interaction with NF‐κB and Sp1 binding motifs 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Kruppel‐associated box‐containing zinc finger (KRAB‐ZNF) genes constitute the single largest gene family of transcriptional repressors in the genomes of higher organisms. In this study, we isolated 52 cDNA clones of KRAB‐ZFPs from U1 cell lines and screened them to identify which were capable of regulating HIV‐1 gene expression. We identified 5 KRAB‐ZFPs that suppressed ⩾50% of HIV‐1 LTR. Of the 5 identified KRAB‐ZFPs, the expression of ZNF10 significantly enhanced the transcriptional repression activity of the LTR compared with other ZNFs. In addition, the depletion of endogenous ZNF10 led to the activation of HIV‐1 LTR. The repressor activity of ZNF10 was required for TRIM28, SETDB1 and HP1‐gamma binding. These results indicate that ZNF10 could be involved in a potent intrinsic antiretroviral defense. We isolated 52 cDNA clones of Kruppel‐related zinc finger genes from U1 cell lines. Over expression of ZNF10 represses HIV LTR‐mediated transcription to a greater extent than other ZNFs. The depletion of ZNF10 leads to the activation of HIV‐1 LTR. Repressor activity of ZNF10 is required for TRIM28, SETDB1, and HP1‐gamma, binding. Nutzungsrecht: FEBS Letters 589 (2015) 1873-3468 © 2015 Federation of European Biochemical Societies Copyright © 2015. Published by Elsevier B.V. SETDB1 HIV-1 LTR HP1-gamma KRAB domain Zinc finger protein TRIM28 Repressor Proteins - physiology Sp1 Transcription Factor - metabolism HIV-1 - genetics Kruppel-Like Transcription Factors - physiology NF-kappa B - metabolism HIV Long Terminal Repeat - physiology Sawada, Leila oth Sugiyama, Ryuichi oth Takaku, Hiroshi oth Enthalten in FEBS letters Amsterdam [u.a.] : Elsevier, 1968 589(2015), 15, Seite 2019-2025 (DE-627)129522023 (DE-600)212746-5 (DE-576)014938014 0014-5793 nnns volume:589 year:2015 number:15 pages:2019-2025 http://dx.doi.org/10.1016/j.febslet.2015.06.013 Volltext http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2015.06.013/abstract http://www.ncbi.nlm.nih.gov/pubmed/26096782 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_70 GBV_ILN_211 GBV_ILN_2219 GBV_ILN_4012 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 AR 589 2015 15 2019-2025 |
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Nishitsuji, Hironori |
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Nishitsuji, Hironori ddc 570 misc SETDB1 misc HIV-1 LTR misc HP1-gamma misc KRAB domain misc Zinc finger protein misc TRIM28 misc Repressor Proteins - physiology misc Sp1 Transcription Factor - metabolism misc HIV-1 - genetics misc Kruppel-Like Transcription Factors - physiology misc NF-kappa B - metabolism misc HIV Long Terminal Repeat - physiology ZNF10 inhibits HIV‐1 LTR activity through interaction with NF‐κB and Sp1 binding motifs |
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ZNF10 inhibits HIV‐1 LTR activity through interaction with NF‐κB and Sp1 binding motifs |
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znf10 inhibits hiv‐1 ltr activity through interaction with nf‐κb and sp1 binding motifs |
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ZNF10 inhibits HIV‐1 LTR activity through interaction with NF‐κB and Sp1 binding motifs |
| abstract |
Kruppel‐associated box‐containing zinc finger (KRAB‐ZNF) genes constitute the single largest gene family of transcriptional repressors in the genomes of higher organisms. In this study, we isolated 52 cDNA clones of KRAB‐ZFPs from U1 cell lines and screened them to identify which were capable of regulating HIV‐1 gene expression. We identified 5 KRAB‐ZFPs that suppressed ⩾50% of HIV‐1 LTR. Of the 5 identified KRAB‐ZFPs, the expression of ZNF10 significantly enhanced the transcriptional repression activity of the LTR compared with other ZNFs. In addition, the depletion of endogenous ZNF10 led to the activation of HIV‐1 LTR. The repressor activity of ZNF10 was required for TRIM28, SETDB1 and HP1‐gamma binding. These results indicate that ZNF10 could be involved in a potent intrinsic antiretroviral defense. We isolated 52 cDNA clones of Kruppel‐related zinc finger genes from U1 cell lines. Over expression of ZNF10 represses HIV LTR‐mediated transcription to a greater extent than other ZNFs. The depletion of ZNF10 leads to the activation of HIV‐1 LTR. Repressor activity of ZNF10 is required for TRIM28, SETDB1, and HP1‐gamma, binding. |
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Kruppel‐associated box‐containing zinc finger (KRAB‐ZNF) genes constitute the single largest gene family of transcriptional repressors in the genomes of higher organisms. In this study, we isolated 52 cDNA clones of KRAB‐ZFPs from U1 cell lines and screened them to identify which were capable of regulating HIV‐1 gene expression. We identified 5 KRAB‐ZFPs that suppressed ⩾50% of HIV‐1 LTR. Of the 5 identified KRAB‐ZFPs, the expression of ZNF10 significantly enhanced the transcriptional repression activity of the LTR compared with other ZNFs. In addition, the depletion of endogenous ZNF10 led to the activation of HIV‐1 LTR. The repressor activity of ZNF10 was required for TRIM28, SETDB1 and HP1‐gamma binding. These results indicate that ZNF10 could be involved in a potent intrinsic antiretroviral defense. We isolated 52 cDNA clones of Kruppel‐related zinc finger genes from U1 cell lines. Over expression of ZNF10 represses HIV LTR‐mediated transcription to a greater extent than other ZNFs. The depletion of ZNF10 leads to the activation of HIV‐1 LTR. Repressor activity of ZNF10 is required for TRIM28, SETDB1, and HP1‐gamma, binding. |
| abstract_unstemmed |
Kruppel‐associated box‐containing zinc finger (KRAB‐ZNF) genes constitute the single largest gene family of transcriptional repressors in the genomes of higher organisms. In this study, we isolated 52 cDNA clones of KRAB‐ZFPs from U1 cell lines and screened them to identify which were capable of regulating HIV‐1 gene expression. We identified 5 KRAB‐ZFPs that suppressed ⩾50% of HIV‐1 LTR. Of the 5 identified KRAB‐ZFPs, the expression of ZNF10 significantly enhanced the transcriptional repression activity of the LTR compared with other ZNFs. In addition, the depletion of endogenous ZNF10 led to the activation of HIV‐1 LTR. The repressor activity of ZNF10 was required for TRIM28, SETDB1 and HP1‐gamma binding. These results indicate that ZNF10 could be involved in a potent intrinsic antiretroviral defense. We isolated 52 cDNA clones of Kruppel‐related zinc finger genes from U1 cell lines. Over expression of ZNF10 represses HIV LTR‐mediated transcription to a greater extent than other ZNFs. The depletion of ZNF10 leads to the activation of HIV‐1 LTR. Repressor activity of ZNF10 is required for TRIM28, SETDB1, and HP1‐gamma, binding. |
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ZNF10 inhibits HIV‐1 LTR activity through interaction with NF‐κB and Sp1 binding motifs |
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http://dx.doi.org/10.1016/j.febslet.2015.06.013 http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2015.06.013/abstract http://www.ncbi.nlm.nih.gov/pubmed/26096782 |
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In this study, we isolated 52 cDNA clones of KRAB‐ZFPs from U1 cell lines and screened them to identify which were capable of regulating HIV‐1 gene expression. We identified 5 KRAB‐ZFPs that suppressed ⩾50% of HIV‐1 LTR. Of the 5 identified KRAB‐ZFPs, the expression of ZNF10 significantly enhanced the transcriptional repression activity of the LTR compared with other ZNFs. In addition, the depletion of endogenous ZNF10 led to the activation of HIV‐1 LTR. The repressor activity of ZNF10 was required for TRIM28, SETDB1 and HP1‐gamma binding. These results indicate that ZNF10 could be involved in a potent intrinsic antiretroviral defense. We isolated 52 cDNA clones of Kruppel‐related zinc finger genes from U1 cell lines. Over expression of ZNF10 represses HIV LTR‐mediated transcription to a greater extent than other ZNFs. The depletion of ZNF10 leads to the activation of HIV‐1 LTR. Repressor activity of ZNF10 is required for TRIM28, SETDB1, and HP1‐gamma, binding.</subfield></datafield><datafield tag="540" ind1=" " ind2=" "><subfield code="a">Nutzungsrecht: FEBS Letters 589 (2015) 1873-3468 © 2015 Federation of European Biochemical Societies</subfield></datafield><datafield tag="540" ind1=" " ind2=" "><subfield code="a">Copyright © 2015. Published by Elsevier B.V.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">SETDB1</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">HIV-1 LTR</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">HP1-gamma</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">KRAB domain</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Zinc finger protein</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">TRIM28</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Repressor Proteins - physiology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Sp1 Transcription Factor - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">HIV-1 - genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Kruppel-Like Transcription Factors - physiology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">NF-kappa B - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">HIV Long Terminal Repeat - physiology</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sawada, Leila</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sugiyama, Ryuichi</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Takaku, Hiroshi</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">FEBS letters</subfield><subfield code="d">Amsterdam [u.a.] : Elsevier, 1968</subfield><subfield code="g">589(2015), 15, Seite 2019-2025</subfield><subfield code="w">(DE-627)129522023</subfield><subfield code="w">(DE-600)212746-5</subfield><subfield code="w">(DE-576)014938014</subfield><subfield code="x">0014-5793</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:589</subfield><subfield code="g">year:2015</subfield><subfield code="g">number:15</subfield><subfield code="g">pages:2019-2025</subfield></datafield><datafield tag="856" ind1="4" ind2="1"><subfield code="u">http://dx.doi.org/10.1016/j.febslet.2015.06.013</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2015.06.013/abstract</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">http://www.ncbi.nlm.nih.gov/pubmed/26096782</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_OLC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHY</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-CHE</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-DE-84</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_21</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_211</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2219</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4219</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">589</subfield><subfield code="j">2015</subfield><subfield code="e">15</subfield><subfield code="h">2019-2025</subfield></datafield></record></collection>
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