GDNF–Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease
Glial cell line‐derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal together or independently to fulfill many important functions in the midbrain dopaminergic (DA) system. While Ret signaling clearly impacts on the development, maintenance and regeneration of the mesostriata...
Ausführliche Beschreibung
Autor*in: |
Kramer, Edgar R [verfasserIn] |
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Format: |
Artikel |
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Sprache: |
Englisch |
Erschienen: |
2015 |
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Rechteinformationen: |
Nutzungsrecht: FEBS Letters 589 (2015) 1873-3468 © 2015 Federation of European Biochemical Societies Copyright © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
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Übergeordnetes Werk: |
Enthalten in: FEBS letters - Amsterdam [u.a.] : Elsevier, 1968, 589(2015), 24PartA, Seite 3760-3772 |
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Übergeordnetes Werk: |
volume:589 ; year:2015 ; number:24PartA ; pages:3760-3772 |
Links: |
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DOI / URN: |
10.1016/j.febslet.2015.11.006 |
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Katalog-ID: |
OLC1965550118 |
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245 | 1 | 0 | |a GDNF–Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease |
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520 | |a Glial cell line‐derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal together or independently to fulfill many important functions in the midbrain dopaminergic (DA) system. While Ret signaling clearly impacts on the development, maintenance and regeneration of the mesostriatal DA system, the physiological functions of GDNF for the DA system are still unclear. Nevertheless, GDNF is still considered to be an excellent candidate to protect and/or regenerate the mesostriatal DA system in Parkinson disease (PD). Clinical trials with GDNF on PD patients are, however, so far inconclusive. Here, we review the current knowledge of GDNF and Ret signaling and function in the midbrain DA system, and their crosstalk with proteins and signaling pathways associated with PD. | ||
540 | |a Nutzungsrecht: FEBS Letters 589 (2015) 1873-3468 © 2015 Federation of European Biochemical Societies | ||
540 | |a Copyright © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. | ||
650 | 4 | |a serine and threonine, which can be phosphorylated | |
650 | 4 | |a Parkinson disease | |
650 | 4 | |a SH3 and multiple ankyrin repeat domains 3, proline-rich synapse-associated protein 2 (ProSAP2) | |
650 | 4 | |a cycles between an active GTP-bound and an inactive GDP-bound state | |
650 | 4 | |a GABA | |
650 | 4 | |a glia cell line-derived neurotrophic factor | |
650 | 4 | |a Src | |
650 | 4 | |a (rapidly accelerated fibrosarcoma/rat fibrosarcoma) family of serine/threonine-protein kinase | |
650 | 4 | |a GDNF | |
650 | 4 | |a sensitive, voltage gated A-type K+ channel | |
650 | 4 | |a (sarcoma protein) membrane-associated tyrosine kinase with different Src homology (SH) domains characteristic for all 9 members of the Src family kinases | |
650 | 4 | |a tyrosines, which can be phosphorylated | |
650 | 4 | |a BDNF | |
650 | 4 | |a SHC | |
650 | 4 | |a Mouse model | |
650 | 4 | |a monoamine oxidases A and B | |
650 | 4 | |a hypoxia-inducible factor-1alpha | |
650 | 4 | |a growth factor receptor-bound protein 2, 7 and 10, adaptor proteins | |
650 | 4 | |a Enigma | |
650 | 4 | |a catechol-O-methyltransferase | |
650 | 4 | |a VTA | |
650 | 4 | |a Drug addiction | |
650 | 4 | |a pleckstrin homology domain | |
650 | 4 | |a FRS2 | |
650 | 4 | |a Ret | |
650 | 4 | |a γ-aminobutyric acid, inhibitory neurotransmitter in mammalian central nervous system | |
650 | 4 | |a protein kinase B, serine/threonine-specific protein kinase | |
650 | 4 | |a DAT | |
650 | 4 | |a phosphatase and tensin homolog | |
650 | 4 | |a MAOA/MAOB | |
650 | 4 | |a EGFP | |
650 | 4 | |a multiple endocrine neoplasia 2 type B, mutation in the kinase domain of the Ret leading to constitutive active receptor | |
650 | 4 | |a MPTP | |
650 | 4 | |a early growth response protein 1, Zif268 (zinc finger protein 225), NGFI-A (nerve growth factor-induced protein A), is a zinc finger transcription factor | |
650 | 4 | |a SorLA | |
650 | 4 | |a Cdc42 | |
650 | 4 | |a co-repressor for element-1-silencing transcription factor, a chromatin-modifying corepressor complex that acts with REST (repressor for element-1 silencing transcription factor) complex | |
650 | 4 | |a retro-rubal field | |
650 | 4 | |a calcium-calmodulin-dependent protein kinase II β isoform | |
650 | 4 | |a GFLs | |
650 | 4 | |a 6-OHDA | |
650 | 4 | |a GTPase-activating proteins 1 and 2 | |
650 | 4 | |a 3′,5′-cyclic adenosine monophosphate | |
650 | 4 | |a GDNF family of ligands | |
650 | 4 | |a monoamine, neurotransmitter type including dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline) | |
650 | 4 | |a FosB/ΔFosB | |
650 | 4 | |a NGF | |
650 | 4 | |a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | |
650 | 4 | |a glycogen synthase kinase 3β | |
650 | 4 | |a Rho | |
650 | 4 | |a carbonyl cyanide m-chlorophenyl hydrazone | |
650 | 4 | |a LIM | |
650 | 4 | |a TGF-β | |
650 | 4 | |a Tyr | |
650 | 4 | |a FBJ murine osteosarcoma viral oncogene homolog B, a transcription factor with a truncated Δ form | |
650 | 4 | |a JNK | |
650 | 4 | |a brain derived neurotrophic factor | |
650 | 4 | |a MEN2B | |
650 | 4 | |a GRB2/7/10 | |
650 | 4 | |a CCCP | |
650 | 4 | |a exin type 6 | |
650 | 4 | |a Rac1 | |
650 | 4 | |a CoREST | |
650 | 4 | |a VPS10P | |
650 | 4 | |a Raf | |
650 | 4 | |a Akt, PKB | |
650 | 4 | |a Shank3 | |
650 | 4 | |a single-nucleotide polymorphism analysis | |
650 | 4 | |a neuronal cell adhesion molecule | |
650 | 4 | |a adaptor protein of the PDZ-LIM family | |
650 | 4 | |a Kv4.3 and KChip3 | |
650 | 4 | |a nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cells, transcription factor family with Rel homology domain (RHD) | |
650 | 4 | |a (Ras homolog) family of small GTPases including Cdc42, Rac1, and RhoA | |
650 | 4 | |a SHP-2 | |
650 | 4 | |a MAPK | |
650 | 4 | |a GDNF family receptor α | |
650 | 4 | |a CaMKIIβ | |
650 | 4 | |a PKA | |
650 | 4 | |a RRF | |
650 | 4 | |a PINK1 | |
650 | 4 | |a substantia nigra | |
650 | 4 | |a TIEG | |
650 | 4 | |a PTEN | |
650 | 4 | |a insulin receptor substrate 1, adaptor protein, contains a PTB and PH domain | |
650 | 4 | |a cAMP | |
650 | 4 | |a PACE4, PCSK6 | |
650 | 4 | |a dopamine transporter | |
650 | 4 | |a Ras | |
650 | 4 | |a glycosylphosphatidylinositol | |
650 | 4 | |a GFRα | |
650 | 4 | |a protein kinase A, a family of cAMP-dependent protein kinase | |
650 | 4 | |a son of sevenless, family of guanine nucleotide exchange factors that act on Ras | |
650 | 4 | |a (acronym combining the first letters of three proteins – Lin11, Isl-1 and Mec-3 – that have this common domain) protein interaction domain of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker | |
650 | 4 | |a phosphotyrosine-binding domains | |
650 | 4 | |a enhanced green fluorescent protein | |
650 | 4 | |a HIF-1a | |
650 | 4 | |a EGR1 | |
650 | 4 | |a Ser/Thr | |
650 | 4 | |a (Rat sarcoma) family of small membrane-associated GTPase | |
650 | 4 | |a (acronym combining the first letters of three proteins – post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1) that have this common domain) protein interaction domain | |
700 | 1 | |a Liss, Birgit |4 oth | |
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856 | 4 | 2 | |u http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2015.11.006/abstract |
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10.1016/j.febslet.2015.11.006 doi PQ20160430 (DE-627)OLC1965550118 (DE-599)GBVOLC1965550118 (PRQ)c1941-e56cca3a11fd73e4936073c3b08618a4e5d5e18d491090e6b307882d231592a70 (KEY)0045922420150000589002403760gdnfretsignalinginmidbraindopaminergicneuronsandit DE-627 ger DE-627 rakwb eng 570 530 610 DNB Kramer, Edgar R verfasserin aut GDNF–Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Glial cell line‐derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal together or independently to fulfill many important functions in the midbrain dopaminergic (DA) system. While Ret signaling clearly impacts on the development, maintenance and regeneration of the mesostriatal DA system, the physiological functions of GDNF for the DA system are still unclear. Nevertheless, GDNF is still considered to be an excellent candidate to protect and/or regenerate the mesostriatal DA system in Parkinson disease (PD). Clinical trials with GDNF on PD patients are, however, so far inconclusive. Here, we review the current knowledge of GDNF and Ret signaling and function in the midbrain DA system, and their crosstalk with proteins and signaling pathways associated with PD. Nutzungsrecht: FEBS Letters 589 (2015) 1873-3468 © 2015 Federation of European Biochemical Societies Copyright © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. serine and threonine, which can be phosphorylated Parkinson disease SH3 and multiple ankyrin repeat domains 3, proline-rich synapse-associated protein 2 (ProSAP2) cycles between an active GTP-bound and an inactive GDP-bound state GABA glia cell line-derived neurotrophic factor Src (rapidly accelerated fibrosarcoma/rat fibrosarcoma) family of serine/threonine-protein kinase GDNF sensitive, voltage gated A-type K+ channel (sarcoma protein) membrane-associated tyrosine kinase with different Src homology (SH) domains characteristic for all 9 members of the Src family kinases tyrosines, which can be phosphorylated BDNF SHC Mouse model monoamine oxidases A and B hypoxia-inducible factor-1alpha growth factor receptor-bound protein 2, 7 and 10, adaptor proteins Enigma catechol-O-methyltransferase VTA Drug addiction pleckstrin homology domain FRS2 Ret γ-aminobutyric acid, inhibitory neurotransmitter in mammalian central nervous system protein kinase B, serine/threonine-specific protein kinase DAT phosphatase and tensin homolog MAOA/MAOB EGFP multiple endocrine neoplasia 2 type B, mutation in the kinase domain of the Ret leading to constitutive active receptor MPTP early growth response protein 1, Zif268 (zinc finger protein 225), NGFI-A (nerve growth factor-induced protein A), is a zinc finger transcription factor SorLA Cdc42 co-repressor for element-1-silencing transcription factor, a chromatin-modifying corepressor complex that acts with REST (repressor for element-1 silencing transcription factor) complex retro-rubal field calcium-calmodulin-dependent protein kinase II β isoform GFLs 6-OHDA GTPase-activating proteins 1 and 2 3′,5′-cyclic adenosine monophosphate GDNF family of ligands monoamine, neurotransmitter type including dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline) FosB/ΔFosB NGF 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine glycogen synthase kinase 3β Rho carbonyl cyanide m-chlorophenyl hydrazone LIM TGF-β Tyr FBJ murine osteosarcoma viral oncogene homolog B, a transcription factor with a truncated Δ form JNK brain derived neurotrophic factor MEN2B GRB2/7/10 CCCP exin type 6 Rac1 CoREST VPS10P Raf Akt, PKB Shank3 single-nucleotide polymorphism analysis neuronal cell adhesion molecule adaptor protein of the PDZ-LIM family Kv4.3 and KChip3 nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cells, transcription factor family with Rel homology domain (RHD) (Ras homolog) family of small GTPases including Cdc42, Rac1, and RhoA SHP-2 MAPK GDNF family receptor α CaMKIIβ PKA RRF PINK1 substantia nigra TIEG PTEN insulin receptor substrate 1, adaptor protein, contains a PTB and PH domain cAMP PACE4, PCSK6 dopamine transporter Ras glycosylphosphatidylinositol GFRα protein kinase A, a family of cAMP-dependent protein kinase son of sevenless, family of guanine nucleotide exchange factors that act on Ras (acronym combining the first letters of three proteins – Lin11, Isl-1 and Mec-3 – that have this common domain) protein interaction domain of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker phosphotyrosine-binding domains enhanced green fluorescent protein HIF-1a EGR1 Ser/Thr (Rat sarcoma) family of small membrane-associated GTPase (acronym combining the first letters of three proteins – post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1) that have this common domain) protein interaction domain Liss, Birgit oth Enthalten in FEBS letters Amsterdam [u.a.] : Elsevier, 1968 589(2015), 24PartA, Seite 3760-3772 (DE-627)129522023 (DE-600)212746-5 (DE-576)014938014 0014-5793 nnns volume:589 year:2015 number:24PartA pages:3760-3772 http://dx.doi.org/10.1016/j.febslet.2015.11.006 Volltext http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2015.11.006/abstract http://www.ncbi.nlm.nih.gov/pubmed/26555190 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_70 GBV_ILN_211 GBV_ILN_2219 GBV_ILN_4012 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 AR 589 2015 24PartA 3760-3772 |
spelling |
10.1016/j.febslet.2015.11.006 doi PQ20160430 (DE-627)OLC1965550118 (DE-599)GBVOLC1965550118 (PRQ)c1941-e56cca3a11fd73e4936073c3b08618a4e5d5e18d491090e6b307882d231592a70 (KEY)0045922420150000589002403760gdnfretsignalinginmidbraindopaminergicneuronsandit DE-627 ger DE-627 rakwb eng 570 530 610 DNB Kramer, Edgar R verfasserin aut GDNF–Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Glial cell line‐derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal together or independently to fulfill many important functions in the midbrain dopaminergic (DA) system. While Ret signaling clearly impacts on the development, maintenance and regeneration of the mesostriatal DA system, the physiological functions of GDNF for the DA system are still unclear. Nevertheless, GDNF is still considered to be an excellent candidate to protect and/or regenerate the mesostriatal DA system in Parkinson disease (PD). Clinical trials with GDNF on PD patients are, however, so far inconclusive. Here, we review the current knowledge of GDNF and Ret signaling and function in the midbrain DA system, and their crosstalk with proteins and signaling pathways associated with PD. Nutzungsrecht: FEBS Letters 589 (2015) 1873-3468 © 2015 Federation of European Biochemical Societies Copyright © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. serine and threonine, which can be phosphorylated Parkinson disease SH3 and multiple ankyrin repeat domains 3, proline-rich synapse-associated protein 2 (ProSAP2) cycles between an active GTP-bound and an inactive GDP-bound state GABA glia cell line-derived neurotrophic factor Src (rapidly accelerated fibrosarcoma/rat fibrosarcoma) family of serine/threonine-protein kinase GDNF sensitive, voltage gated A-type K+ channel (sarcoma protein) membrane-associated tyrosine kinase with different Src homology (SH) domains characteristic for all 9 members of the Src family kinases tyrosines, which can be phosphorylated BDNF SHC Mouse model monoamine oxidases A and B hypoxia-inducible factor-1alpha growth factor receptor-bound protein 2, 7 and 10, adaptor proteins Enigma catechol-O-methyltransferase VTA Drug addiction pleckstrin homology domain FRS2 Ret γ-aminobutyric acid, inhibitory neurotransmitter in mammalian central nervous system protein kinase B, serine/threonine-specific protein kinase DAT phosphatase and tensin homolog MAOA/MAOB EGFP multiple endocrine neoplasia 2 type B, mutation in the kinase domain of the Ret leading to constitutive active receptor MPTP early growth response protein 1, Zif268 (zinc finger protein 225), NGFI-A (nerve growth factor-induced protein A), is a zinc finger transcription factor SorLA Cdc42 co-repressor for element-1-silencing transcription factor, a chromatin-modifying corepressor complex that acts with REST (repressor for element-1 silencing transcription factor) complex retro-rubal field calcium-calmodulin-dependent protein kinase II β isoform GFLs 6-OHDA GTPase-activating proteins 1 and 2 3′,5′-cyclic adenosine monophosphate GDNF family of ligands monoamine, neurotransmitter type including dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline) FosB/ΔFosB NGF 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine glycogen synthase kinase 3β Rho carbonyl cyanide m-chlorophenyl hydrazone LIM TGF-β Tyr FBJ murine osteosarcoma viral oncogene homolog B, a transcription factor with a truncated Δ form JNK brain derived neurotrophic factor MEN2B GRB2/7/10 CCCP exin type 6 Rac1 CoREST VPS10P Raf Akt, PKB Shank3 single-nucleotide polymorphism analysis neuronal cell adhesion molecule adaptor protein of the PDZ-LIM family Kv4.3 and KChip3 nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cells, transcription factor family with Rel homology domain (RHD) (Ras homolog) family of small GTPases including Cdc42, Rac1, and RhoA SHP-2 MAPK GDNF family receptor α CaMKIIβ PKA RRF PINK1 substantia nigra TIEG PTEN insulin receptor substrate 1, adaptor protein, contains a PTB and PH domain cAMP PACE4, PCSK6 dopamine transporter Ras glycosylphosphatidylinositol GFRα protein kinase A, a family of cAMP-dependent protein kinase son of sevenless, family of guanine nucleotide exchange factors that act on Ras (acronym combining the first letters of three proteins – Lin11, Isl-1 and Mec-3 – that have this common domain) protein interaction domain of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker phosphotyrosine-binding domains enhanced green fluorescent protein HIF-1a EGR1 Ser/Thr (Rat sarcoma) family of small membrane-associated GTPase (acronym combining the first letters of three proteins – post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1) that have this common domain) protein interaction domain Liss, Birgit oth Enthalten in FEBS letters Amsterdam [u.a.] : Elsevier, 1968 589(2015), 24PartA, Seite 3760-3772 (DE-627)129522023 (DE-600)212746-5 (DE-576)014938014 0014-5793 nnns volume:589 year:2015 number:24PartA pages:3760-3772 http://dx.doi.org/10.1016/j.febslet.2015.11.006 Volltext http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2015.11.006/abstract http://www.ncbi.nlm.nih.gov/pubmed/26555190 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_70 GBV_ILN_211 GBV_ILN_2219 GBV_ILN_4012 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 AR 589 2015 24PartA 3760-3772 |
allfields_unstemmed |
10.1016/j.febslet.2015.11.006 doi PQ20160430 (DE-627)OLC1965550118 (DE-599)GBVOLC1965550118 (PRQ)c1941-e56cca3a11fd73e4936073c3b08618a4e5d5e18d491090e6b307882d231592a70 (KEY)0045922420150000589002403760gdnfretsignalinginmidbraindopaminergicneuronsandit DE-627 ger DE-627 rakwb eng 570 530 610 DNB Kramer, Edgar R verfasserin aut GDNF–Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Glial cell line‐derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal together or independently to fulfill many important functions in the midbrain dopaminergic (DA) system. While Ret signaling clearly impacts on the development, maintenance and regeneration of the mesostriatal DA system, the physiological functions of GDNF for the DA system are still unclear. Nevertheless, GDNF is still considered to be an excellent candidate to protect and/or regenerate the mesostriatal DA system in Parkinson disease (PD). Clinical trials with GDNF on PD patients are, however, so far inconclusive. Here, we review the current knowledge of GDNF and Ret signaling and function in the midbrain DA system, and their crosstalk with proteins and signaling pathways associated with PD. Nutzungsrecht: FEBS Letters 589 (2015) 1873-3468 © 2015 Federation of European Biochemical Societies Copyright © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. serine and threonine, which can be phosphorylated Parkinson disease SH3 and multiple ankyrin repeat domains 3, proline-rich synapse-associated protein 2 (ProSAP2) cycles between an active GTP-bound and an inactive GDP-bound state GABA glia cell line-derived neurotrophic factor Src (rapidly accelerated fibrosarcoma/rat fibrosarcoma) family of serine/threonine-protein kinase GDNF sensitive, voltage gated A-type K+ channel (sarcoma protein) membrane-associated tyrosine kinase with different Src homology (SH) domains characteristic for all 9 members of the Src family kinases tyrosines, which can be phosphorylated BDNF SHC Mouse model monoamine oxidases A and B hypoxia-inducible factor-1alpha growth factor receptor-bound protein 2, 7 and 10, adaptor proteins Enigma catechol-O-methyltransferase VTA Drug addiction pleckstrin homology domain FRS2 Ret γ-aminobutyric acid, inhibitory neurotransmitter in mammalian central nervous system protein kinase B, serine/threonine-specific protein kinase DAT phosphatase and tensin homolog MAOA/MAOB EGFP multiple endocrine neoplasia 2 type B, mutation in the kinase domain of the Ret leading to constitutive active receptor MPTP early growth response protein 1, Zif268 (zinc finger protein 225), NGFI-A (nerve growth factor-induced protein A), is a zinc finger transcription factor SorLA Cdc42 co-repressor for element-1-silencing transcription factor, a chromatin-modifying corepressor complex that acts with REST (repressor for element-1 silencing transcription factor) complex retro-rubal field calcium-calmodulin-dependent protein kinase II β isoform GFLs 6-OHDA GTPase-activating proteins 1 and 2 3′,5′-cyclic adenosine monophosphate GDNF family of ligands monoamine, neurotransmitter type including dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline) FosB/ΔFosB NGF 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine glycogen synthase kinase 3β Rho carbonyl cyanide m-chlorophenyl hydrazone LIM TGF-β Tyr FBJ murine osteosarcoma viral oncogene homolog B, a transcription factor with a truncated Δ form JNK brain derived neurotrophic factor MEN2B GRB2/7/10 CCCP exin type 6 Rac1 CoREST VPS10P Raf Akt, PKB Shank3 single-nucleotide polymorphism analysis neuronal cell adhesion molecule adaptor protein of the PDZ-LIM family Kv4.3 and KChip3 nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cells, transcription factor family with Rel homology domain (RHD) (Ras homolog) family of small GTPases including Cdc42, Rac1, and RhoA SHP-2 MAPK GDNF family receptor α CaMKIIβ PKA RRF PINK1 substantia nigra TIEG PTEN insulin receptor substrate 1, adaptor protein, contains a PTB and PH domain cAMP PACE4, PCSK6 dopamine transporter Ras glycosylphosphatidylinositol GFRα protein kinase A, a family of cAMP-dependent protein kinase son of sevenless, family of guanine nucleotide exchange factors that act on Ras (acronym combining the first letters of three proteins – Lin11, Isl-1 and Mec-3 – that have this common domain) protein interaction domain of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker phosphotyrosine-binding domains enhanced green fluorescent protein HIF-1a EGR1 Ser/Thr (Rat sarcoma) family of small membrane-associated GTPase (acronym combining the first letters of three proteins – post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1) that have this common domain) protein interaction domain Liss, Birgit oth Enthalten in FEBS letters Amsterdam [u.a.] : Elsevier, 1968 589(2015), 24PartA, Seite 3760-3772 (DE-627)129522023 (DE-600)212746-5 (DE-576)014938014 0014-5793 nnns volume:589 year:2015 number:24PartA pages:3760-3772 http://dx.doi.org/10.1016/j.febslet.2015.11.006 Volltext http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2015.11.006/abstract http://www.ncbi.nlm.nih.gov/pubmed/26555190 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_70 GBV_ILN_211 GBV_ILN_2219 GBV_ILN_4012 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 AR 589 2015 24PartA 3760-3772 |
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10.1016/j.febslet.2015.11.006 doi PQ20160430 (DE-627)OLC1965550118 (DE-599)GBVOLC1965550118 (PRQ)c1941-e56cca3a11fd73e4936073c3b08618a4e5d5e18d491090e6b307882d231592a70 (KEY)0045922420150000589002403760gdnfretsignalinginmidbraindopaminergicneuronsandit DE-627 ger DE-627 rakwb eng 570 530 610 DNB Kramer, Edgar R verfasserin aut GDNF–Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Glial cell line‐derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal together or independently to fulfill many important functions in the midbrain dopaminergic (DA) system. While Ret signaling clearly impacts on the development, maintenance and regeneration of the mesostriatal DA system, the physiological functions of GDNF for the DA system are still unclear. Nevertheless, GDNF is still considered to be an excellent candidate to protect and/or regenerate the mesostriatal DA system in Parkinson disease (PD). Clinical trials with GDNF on PD patients are, however, so far inconclusive. Here, we review the current knowledge of GDNF and Ret signaling and function in the midbrain DA system, and their crosstalk with proteins and signaling pathways associated with PD. Nutzungsrecht: FEBS Letters 589 (2015) 1873-3468 © 2015 Federation of European Biochemical Societies Copyright © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. serine and threonine, which can be phosphorylated Parkinson disease SH3 and multiple ankyrin repeat domains 3, proline-rich synapse-associated protein 2 (ProSAP2) cycles between an active GTP-bound and an inactive GDP-bound state GABA glia cell line-derived neurotrophic factor Src (rapidly accelerated fibrosarcoma/rat fibrosarcoma) family of serine/threonine-protein kinase GDNF sensitive, voltage gated A-type K+ channel (sarcoma protein) membrane-associated tyrosine kinase with different Src homology (SH) domains characteristic for all 9 members of the Src family kinases tyrosines, which can be phosphorylated BDNF SHC Mouse model monoamine oxidases A and B hypoxia-inducible factor-1alpha growth factor receptor-bound protein 2, 7 and 10, adaptor proteins Enigma catechol-O-methyltransferase VTA Drug addiction pleckstrin homology domain FRS2 Ret γ-aminobutyric acid, inhibitory neurotransmitter in mammalian central nervous system protein kinase B, serine/threonine-specific protein kinase DAT phosphatase and tensin homolog MAOA/MAOB EGFP multiple endocrine neoplasia 2 type B, mutation in the kinase domain of the Ret leading to constitutive active receptor MPTP early growth response protein 1, Zif268 (zinc finger protein 225), NGFI-A (nerve growth factor-induced protein A), is a zinc finger transcription factor SorLA Cdc42 co-repressor for element-1-silencing transcription factor, a chromatin-modifying corepressor complex that acts with REST (repressor for element-1 silencing transcription factor) complex retro-rubal field calcium-calmodulin-dependent protein kinase II β isoform GFLs 6-OHDA GTPase-activating proteins 1 and 2 3′,5′-cyclic adenosine monophosphate GDNF family of ligands monoamine, neurotransmitter type including dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline) FosB/ΔFosB NGF 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine glycogen synthase kinase 3β Rho carbonyl cyanide m-chlorophenyl hydrazone LIM TGF-β Tyr FBJ murine osteosarcoma viral oncogene homolog B, a transcription factor with a truncated Δ form JNK brain derived neurotrophic factor MEN2B GRB2/7/10 CCCP exin type 6 Rac1 CoREST VPS10P Raf Akt, PKB Shank3 single-nucleotide polymorphism analysis neuronal cell adhesion molecule adaptor protein of the PDZ-LIM family Kv4.3 and KChip3 nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cells, transcription factor family with Rel homology domain (RHD) (Ras homolog) family of small GTPases including Cdc42, Rac1, and RhoA SHP-2 MAPK GDNF family receptor α CaMKIIβ PKA RRF PINK1 substantia nigra TIEG PTEN insulin receptor substrate 1, adaptor protein, contains a PTB and PH domain cAMP PACE4, PCSK6 dopamine transporter Ras glycosylphosphatidylinositol GFRα protein kinase A, a family of cAMP-dependent protein kinase son of sevenless, family of guanine nucleotide exchange factors that act on Ras (acronym combining the first letters of three proteins – Lin11, Isl-1 and Mec-3 – that have this common domain) protein interaction domain of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker phosphotyrosine-binding domains enhanced green fluorescent protein HIF-1a EGR1 Ser/Thr (Rat sarcoma) family of small membrane-associated GTPase (acronym combining the first letters of three proteins – post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1) that have this common domain) protein interaction domain Liss, Birgit oth Enthalten in FEBS letters Amsterdam [u.a.] : Elsevier, 1968 589(2015), 24PartA, Seite 3760-3772 (DE-627)129522023 (DE-600)212746-5 (DE-576)014938014 0014-5793 nnns volume:589 year:2015 number:24PartA pages:3760-3772 http://dx.doi.org/10.1016/j.febslet.2015.11.006 Volltext http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2015.11.006/abstract http://www.ncbi.nlm.nih.gov/pubmed/26555190 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_70 GBV_ILN_211 GBV_ILN_2219 GBV_ILN_4012 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 AR 589 2015 24PartA 3760-3772 |
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10.1016/j.febslet.2015.11.006 doi PQ20160430 (DE-627)OLC1965550118 (DE-599)GBVOLC1965550118 (PRQ)c1941-e56cca3a11fd73e4936073c3b08618a4e5d5e18d491090e6b307882d231592a70 (KEY)0045922420150000589002403760gdnfretsignalinginmidbraindopaminergicneuronsandit DE-627 ger DE-627 rakwb eng 570 530 610 DNB Kramer, Edgar R verfasserin aut GDNF–Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Glial cell line‐derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal together or independently to fulfill many important functions in the midbrain dopaminergic (DA) system. While Ret signaling clearly impacts on the development, maintenance and regeneration of the mesostriatal DA system, the physiological functions of GDNF for the DA system are still unclear. Nevertheless, GDNF is still considered to be an excellent candidate to protect and/or regenerate the mesostriatal DA system in Parkinson disease (PD). Clinical trials with GDNF on PD patients are, however, so far inconclusive. Here, we review the current knowledge of GDNF and Ret signaling and function in the midbrain DA system, and their crosstalk with proteins and signaling pathways associated with PD. Nutzungsrecht: FEBS Letters 589 (2015) 1873-3468 © 2015 Federation of European Biochemical Societies Copyright © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. serine and threonine, which can be phosphorylated Parkinson disease SH3 and multiple ankyrin repeat domains 3, proline-rich synapse-associated protein 2 (ProSAP2) cycles between an active GTP-bound and an inactive GDP-bound state GABA glia cell line-derived neurotrophic factor Src (rapidly accelerated fibrosarcoma/rat fibrosarcoma) family of serine/threonine-protein kinase GDNF sensitive, voltage gated A-type K+ channel (sarcoma protein) membrane-associated tyrosine kinase with different Src homology (SH) domains characteristic for all 9 members of the Src family kinases tyrosines, which can be phosphorylated BDNF SHC Mouse model monoamine oxidases A and B hypoxia-inducible factor-1alpha growth factor receptor-bound protein 2, 7 and 10, adaptor proteins Enigma catechol-O-methyltransferase VTA Drug addiction pleckstrin homology domain FRS2 Ret γ-aminobutyric acid, inhibitory neurotransmitter in mammalian central nervous system protein kinase B, serine/threonine-specific protein kinase DAT phosphatase and tensin homolog MAOA/MAOB EGFP multiple endocrine neoplasia 2 type B, mutation in the kinase domain of the Ret leading to constitutive active receptor MPTP early growth response protein 1, Zif268 (zinc finger protein 225), NGFI-A (nerve growth factor-induced protein A), is a zinc finger transcription factor SorLA Cdc42 co-repressor for element-1-silencing transcription factor, a chromatin-modifying corepressor complex that acts with REST (repressor for element-1 silencing transcription factor) complex retro-rubal field calcium-calmodulin-dependent protein kinase II β isoform GFLs 6-OHDA GTPase-activating proteins 1 and 2 3′,5′-cyclic adenosine monophosphate GDNF family of ligands monoamine, neurotransmitter type including dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline) FosB/ΔFosB NGF 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine glycogen synthase kinase 3β Rho carbonyl cyanide m-chlorophenyl hydrazone LIM TGF-β Tyr FBJ murine osteosarcoma viral oncogene homolog B, a transcription factor with a truncated Δ form JNK brain derived neurotrophic factor MEN2B GRB2/7/10 CCCP exin type 6 Rac1 CoREST VPS10P Raf Akt, PKB Shank3 single-nucleotide polymorphism analysis neuronal cell adhesion molecule adaptor protein of the PDZ-LIM family Kv4.3 and KChip3 nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cells, transcription factor family with Rel homology domain (RHD) (Ras homolog) family of small GTPases including Cdc42, Rac1, and RhoA SHP-2 MAPK GDNF family receptor α CaMKIIβ PKA RRF PINK1 substantia nigra TIEG PTEN insulin receptor substrate 1, adaptor protein, contains a PTB and PH domain cAMP PACE4, PCSK6 dopamine transporter Ras glycosylphosphatidylinositol GFRα protein kinase A, a family of cAMP-dependent protein kinase son of sevenless, family of guanine nucleotide exchange factors that act on Ras (acronym combining the first letters of three proteins – Lin11, Isl-1 and Mec-3 – that have this common domain) protein interaction domain of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker phosphotyrosine-binding domains enhanced green fluorescent protein HIF-1a EGR1 Ser/Thr (Rat sarcoma) family of small membrane-associated GTPase (acronym combining the first letters of three proteins – post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1) that have this common domain) protein interaction domain Liss, Birgit oth Enthalten in FEBS letters Amsterdam [u.a.] : Elsevier, 1968 589(2015), 24PartA, Seite 3760-3772 (DE-627)129522023 (DE-600)212746-5 (DE-576)014938014 0014-5793 nnns volume:589 year:2015 number:24PartA pages:3760-3772 http://dx.doi.org/10.1016/j.febslet.2015.11.006 Volltext http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2015.11.006/abstract http://www.ncbi.nlm.nih.gov/pubmed/26555190 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_21 GBV_ILN_70 GBV_ILN_211 GBV_ILN_2219 GBV_ILN_4012 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4305 AR 589 2015 24PartA 3760-3772 |
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serine and threonine, which can be phosphorylated Parkinson disease SH3 and multiple ankyrin repeat domains 3, proline-rich synapse-associated protein 2 (ProSAP2) cycles between an active GTP-bound and an inactive GDP-bound state GABA glia cell line-derived neurotrophic factor Src (rapidly accelerated fibrosarcoma/rat fibrosarcoma) family of serine/threonine-protein kinase GDNF sensitive, voltage gated A-type K+ channel (sarcoma protein) membrane-associated tyrosine kinase with different Src homology (SH) domains characteristic for all 9 members of the Src family kinases tyrosines, which can be phosphorylated BDNF SHC Mouse model monoamine oxidases A and B hypoxia-inducible factor-1alpha growth factor receptor-bound protein 2, 7 and 10, adaptor proteins Enigma catechol-O-methyltransferase VTA Drug addiction pleckstrin homology domain FRS2 Ret γ-aminobutyric acid, inhibitory neurotransmitter in mammalian central nervous system protein kinase B, serine/threonine-specific protein kinase DAT phosphatase and tensin homolog MAOA/MAOB EGFP multiple endocrine neoplasia 2 type B, mutation in the kinase domain of the Ret leading to constitutive active receptor MPTP early growth response protein 1, Zif268 (zinc finger protein 225), NGFI-A (nerve growth factor-induced protein A), is a zinc finger transcription factor SorLA Cdc42 co-repressor for element-1-silencing transcription factor, a chromatin-modifying corepressor complex that acts with REST (repressor for element-1 silencing transcription factor) complex retro-rubal field calcium-calmodulin-dependent protein kinase II β isoform GFLs 6-OHDA GTPase-activating proteins 1 and 2 3′,5′-cyclic adenosine monophosphate GDNF family of ligands monoamine, neurotransmitter type including dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline) FosB/ΔFosB NGF 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine glycogen synthase kinase 3β Rho carbonyl cyanide m-chlorophenyl hydrazone LIM TGF-β Tyr FBJ murine osteosarcoma viral oncogene homolog B, a transcription factor with a truncated Δ form JNK brain derived neurotrophic factor MEN2B GRB2/7/10 CCCP exin type 6 Rac1 CoREST VPS10P Raf Akt, PKB Shank3 single-nucleotide polymorphism analysis neuronal cell adhesion molecule adaptor protein of the PDZ-LIM family Kv4.3 and KChip3 nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cells, transcription factor family with Rel homology domain (RHD) (Ras homolog) family of small GTPases including Cdc42, Rac1, and RhoA SHP-2 MAPK GDNF family receptor α CaMKIIβ PKA RRF PINK1 substantia nigra TIEG PTEN insulin receptor substrate 1, adaptor protein, contains a PTB and PH domain cAMP PACE4, PCSK6 dopamine transporter Ras glycosylphosphatidylinositol GFRα protein kinase A, a family of cAMP-dependent protein kinase son of sevenless, family of guanine nucleotide exchange factors that act on Ras (acronym combining the first letters of three proteins – Lin11, Isl-1 and Mec-3 – that have this common domain) protein interaction domain of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker phosphotyrosine-binding domains enhanced green fluorescent protein HIF-1a EGR1 Ser/Thr (Rat sarcoma) family of small membrane-associated GTPase (acronym combining the first letters of three proteins – post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1) that have this common domain) protein interaction domain |
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|
author |
Kramer, Edgar R |
spellingShingle |
Kramer, Edgar R ddc 570 misc serine and threonine, which can be phosphorylated misc Parkinson disease misc SH3 and multiple ankyrin repeat domains 3, proline-rich synapse-associated protein 2 (ProSAP2) misc cycles between an active GTP-bound and an inactive GDP-bound state misc GABA misc glia cell line-derived neurotrophic factor misc Src misc (rapidly accelerated fibrosarcoma/rat fibrosarcoma) family of serine/threonine-protein kinase misc GDNF misc sensitive, voltage gated A-type K+ channel misc (sarcoma protein) membrane-associated tyrosine kinase with different Src homology (SH) domains characteristic for all 9 members of the Src family kinases misc tyrosines, which can be phosphorylated misc BDNF misc SHC misc Mouse model misc monoamine oxidases A and B misc hypoxia-inducible factor-1alpha misc growth factor receptor-bound protein 2, 7 and 10, adaptor proteins misc Enigma misc catechol-O-methyltransferase misc VTA misc Drug addiction misc pleckstrin homology domain misc FRS2 misc Ret misc γ-aminobutyric acid, inhibitory neurotransmitter in mammalian central nervous system misc protein kinase B, serine/threonine-specific protein kinase misc DAT misc phosphatase and tensin homolog misc MAOA/MAOB misc EGFP misc multiple endocrine neoplasia 2 type B, mutation in the kinase domain of the Ret leading to constitutive active receptor misc MPTP misc early growth response protein 1, Zif268 (zinc finger protein 225), NGFI-A (nerve growth factor-induced protein A), is a zinc finger transcription factor misc SorLA misc Cdc42 misc co-repressor for element-1-silencing transcription factor, a chromatin-modifying corepressor complex that acts with REST (repressor for element-1 silencing transcription factor) complex misc retro-rubal field misc calcium-calmodulin-dependent protein kinase II β isoform misc GFLs misc 6-OHDA misc GTPase-activating proteins 1 and 2 misc 3′,5′-cyclic adenosine monophosphate misc GDNF family of ligands misc monoamine, neurotransmitter type including dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline) misc FosB/ΔFosB misc NGF misc 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine misc glycogen synthase kinase 3β misc Rho misc carbonyl cyanide m-chlorophenyl hydrazone misc LIM misc TGF-β misc Tyr misc FBJ murine osteosarcoma viral oncogene homolog B, a transcription factor with a truncated Δ form misc JNK misc brain derived neurotrophic factor misc MEN2B misc GRB2/7/10 misc CCCP misc exin type 6 misc Rac1 misc CoREST misc VPS10P misc Raf misc Akt, PKB misc Shank3 misc single-nucleotide polymorphism analysis misc neuronal cell adhesion molecule misc adaptor protein of the PDZ-LIM family misc Kv4.3 and KChip3 misc nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cells, transcription factor family with Rel homology domain (RHD) misc (Ras homolog) family of small GTPases including Cdc42, Rac1, and RhoA misc SHP-2 misc MAPK misc GDNF family receptor α misc CaMKIIβ misc PKA misc RRF misc PINK1 misc substantia nigra misc TIEG misc PTEN misc insulin receptor substrate 1, adaptor protein, contains a PTB and PH domain misc cAMP misc PACE4, PCSK6 misc dopamine transporter misc Ras misc glycosylphosphatidylinositol misc GFRα misc protein kinase A, a family of cAMP-dependent protein kinase misc son of sevenless, family of guanine nucleotide exchange factors that act on Ras misc (acronym combining the first letters of three proteins – Lin11, Isl-1 and Mec-3 – that have this common domain) protein interaction domain of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker misc phosphotyrosine-binding domains misc enhanced green fluorescent protein misc HIF-1a misc EGR1 misc Ser/Thr misc (Rat sarcoma) family of small membrane-associated GTPase misc (acronym combining the first letters of three proteins – post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1) that have this common domain) protein interaction domain GDNF–Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease |
authorStr |
Kramer, Edgar R |
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Article |
dewey-ones |
570 - Life sciences; biology 530 - Physics 610 - Medicine & health |
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author_role |
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OLC |
remote_str |
false |
illustrated |
Not Illustrated |
issn |
0014-5793 |
topic_title |
570 530 610 DNB GDNF–Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease serine and threonine, which can be phosphorylated Parkinson disease SH3 and multiple ankyrin repeat domains 3, proline-rich synapse-associated protein 2 (ProSAP2) cycles between an active GTP-bound and an inactive GDP-bound state GABA glia cell line-derived neurotrophic factor Src (rapidly accelerated fibrosarcoma/rat fibrosarcoma) family of serine/threonine-protein kinase GDNF sensitive, voltage gated A-type K+ channel (sarcoma protein) membrane-associated tyrosine kinase with different Src homology (SH) domains characteristic for all 9 members of the Src family kinases tyrosines, which can be phosphorylated BDNF SHC Mouse model monoamine oxidases A and B hypoxia-inducible factor-1alpha growth factor receptor-bound protein 2, 7 and 10, adaptor proteins Enigma catechol-O-methyltransferase VTA Drug addiction pleckstrin homology domain FRS2 Ret γ-aminobutyric acid, inhibitory neurotransmitter in mammalian central nervous system protein kinase B, serine/threonine-specific protein kinase DAT phosphatase and tensin homolog MAOA/MAOB EGFP multiple endocrine neoplasia 2 type B, mutation in the kinase domain of the Ret leading to constitutive active receptor MPTP early growth response protein 1, Zif268 (zinc finger protein 225), NGFI-A (nerve growth factor-induced protein A), is a zinc finger transcription factor SorLA Cdc42 co-repressor for element-1-silencing transcription factor, a chromatin-modifying corepressor complex that acts with REST (repressor for element-1 silencing transcription factor) complex retro-rubal field calcium-calmodulin-dependent protein kinase II β isoform GFLs 6-OHDA GTPase-activating proteins 1 and 2 3′,5′-cyclic adenosine monophosphate GDNF family of ligands monoamine, neurotransmitter type including dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline) FosB/ΔFosB NGF 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine glycogen synthase kinase 3β Rho carbonyl cyanide m-chlorophenyl hydrazone LIM TGF-β Tyr FBJ murine osteosarcoma viral oncogene homolog B, a transcription factor with a truncated Δ form JNK brain derived neurotrophic factor MEN2B GRB2/7/10 CCCP exin type 6 Rac1 CoREST VPS10P Raf Akt, PKB Shank3 single-nucleotide polymorphism analysis neuronal cell adhesion molecule adaptor protein of the PDZ-LIM family Kv4.3 and KChip3 nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cells, transcription factor family with Rel homology domain (RHD) (Ras homolog) family of small GTPases including Cdc42, Rac1, and RhoA SHP-2 MAPK GDNF family receptor α CaMKIIβ PKA RRF PINK1 substantia nigra TIEG PTEN insulin receptor substrate 1, adaptor protein, contains a PTB and PH domain cAMP PACE4, PCSK6 dopamine transporter Ras glycosylphosphatidylinositol GFRα protein kinase A, a family of cAMP-dependent protein kinase son of sevenless, family of guanine nucleotide exchange factors that act on Ras (acronym combining the first letters of three proteins – Lin11, Isl-1 and Mec-3 – that have this common domain) protein interaction domain of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker phosphotyrosine-binding domains enhanced green fluorescent protein HIF-1a EGR1 Ser/Thr (Rat sarcoma) family of small membrane-associated GTPase (acronym combining the first letters of three proteins – post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1) that have this common domain) protein interaction domain |
topic |
ddc 570 misc serine and threonine, which can be phosphorylated misc Parkinson disease misc SH3 and multiple ankyrin repeat domains 3, proline-rich synapse-associated protein 2 (ProSAP2) misc cycles between an active GTP-bound and an inactive GDP-bound state misc GABA misc glia cell line-derived neurotrophic factor misc Src misc (rapidly accelerated fibrosarcoma/rat fibrosarcoma) family of serine/threonine-protein kinase misc GDNF misc sensitive, voltage gated A-type K+ channel misc (sarcoma protein) membrane-associated tyrosine kinase with different Src homology (SH) domains characteristic for all 9 members of the Src family kinases misc tyrosines, which can be phosphorylated misc BDNF misc SHC misc Mouse model misc monoamine oxidases A and B misc hypoxia-inducible factor-1alpha misc growth factor receptor-bound protein 2, 7 and 10, adaptor proteins misc Enigma misc catechol-O-methyltransferase misc VTA misc Drug addiction misc pleckstrin homology domain misc FRS2 misc Ret misc γ-aminobutyric acid, inhibitory neurotransmitter in mammalian central nervous system misc protein kinase B, serine/threonine-specific protein kinase misc DAT misc phosphatase and tensin homolog misc MAOA/MAOB misc EGFP misc multiple endocrine neoplasia 2 type B, mutation in the kinase domain of the Ret leading to constitutive active receptor misc MPTP misc early growth response protein 1, Zif268 (zinc finger protein 225), NGFI-A (nerve growth factor-induced protein A), is a zinc finger transcription factor misc SorLA misc Cdc42 misc co-repressor for element-1-silencing transcription factor, a chromatin-modifying corepressor complex that acts with REST (repressor for element-1 silencing transcription factor) complex misc retro-rubal field misc calcium-calmodulin-dependent protein kinase II β isoform misc GFLs misc 6-OHDA misc GTPase-activating proteins 1 and 2 misc 3′,5′-cyclic adenosine monophosphate misc GDNF family of ligands misc monoamine, neurotransmitter type including dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline) misc FosB/ΔFosB misc NGF misc 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine misc glycogen synthase kinase 3β misc Rho misc carbonyl cyanide m-chlorophenyl hydrazone misc LIM misc TGF-β misc Tyr misc FBJ murine osteosarcoma viral oncogene homolog B, a transcription factor with a truncated Δ form misc JNK misc brain derived neurotrophic factor misc MEN2B misc GRB2/7/10 misc CCCP misc exin type 6 misc Rac1 misc CoREST misc VPS10P misc Raf misc Akt, PKB misc Shank3 misc single-nucleotide polymorphism analysis misc neuronal cell adhesion molecule misc adaptor protein of the PDZ-LIM family misc Kv4.3 and KChip3 misc nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cells, transcription factor family with Rel homology domain (RHD) misc (Ras homolog) family of small GTPases including Cdc42, Rac1, and RhoA misc SHP-2 misc MAPK misc GDNF family receptor α misc CaMKIIβ misc PKA misc RRF misc PINK1 misc substantia nigra misc TIEG misc PTEN misc insulin receptor substrate 1, adaptor protein, contains a PTB and PH domain misc cAMP misc PACE4, PCSK6 misc dopamine transporter misc Ras misc glycosylphosphatidylinositol misc GFRα misc protein kinase A, a family of cAMP-dependent protein kinase misc son of sevenless, family of guanine nucleotide exchange factors that act on Ras misc (acronym combining the first letters of three proteins – Lin11, Isl-1 and Mec-3 – that have this common domain) protein interaction domain of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker misc phosphotyrosine-binding domains misc enhanced green fluorescent protein misc HIF-1a misc EGR1 misc Ser/Thr misc (Rat sarcoma) family of small membrane-associated GTPase misc (acronym combining the first letters of three proteins – post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1) that have this common domain) protein interaction domain |
topic_unstemmed |
ddc 570 misc serine and threonine, which can be phosphorylated misc Parkinson disease misc SH3 and multiple ankyrin repeat domains 3, proline-rich synapse-associated protein 2 (ProSAP2) misc cycles between an active GTP-bound and an inactive GDP-bound state misc GABA misc glia cell line-derived neurotrophic factor misc Src misc (rapidly accelerated fibrosarcoma/rat fibrosarcoma) family of serine/threonine-protein kinase misc GDNF misc sensitive, voltage gated A-type K+ channel misc (sarcoma protein) membrane-associated tyrosine kinase with different Src homology (SH) domains characteristic for all 9 members of the Src family kinases misc tyrosines, which can be phosphorylated misc BDNF misc SHC misc Mouse model misc monoamine oxidases A and B misc hypoxia-inducible factor-1alpha misc growth factor receptor-bound protein 2, 7 and 10, adaptor proteins misc Enigma misc catechol-O-methyltransferase misc VTA misc Drug addiction misc pleckstrin homology domain misc FRS2 misc Ret misc γ-aminobutyric acid, inhibitory neurotransmitter in mammalian central nervous system misc protein kinase B, serine/threonine-specific protein kinase misc DAT misc phosphatase and tensin homolog misc MAOA/MAOB misc EGFP misc multiple endocrine neoplasia 2 type B, mutation in the kinase domain of the Ret leading to constitutive active receptor misc MPTP misc early growth response protein 1, Zif268 (zinc finger protein 225), NGFI-A (nerve growth factor-induced protein A), is a zinc finger transcription factor misc SorLA misc Cdc42 misc co-repressor for element-1-silencing transcription factor, a chromatin-modifying corepressor complex that acts with REST (repressor for element-1 silencing transcription factor) complex misc retro-rubal field misc calcium-calmodulin-dependent protein kinase II β isoform misc GFLs misc 6-OHDA misc GTPase-activating proteins 1 and 2 misc 3′,5′-cyclic adenosine monophosphate misc GDNF family of ligands misc monoamine, neurotransmitter type including dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline) misc FosB/ΔFosB misc NGF misc 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine misc glycogen synthase kinase 3β misc Rho misc carbonyl cyanide m-chlorophenyl hydrazone misc LIM misc TGF-β misc Tyr misc FBJ murine osteosarcoma viral oncogene homolog B, a transcription factor with a truncated Δ form misc JNK misc brain derived neurotrophic factor misc MEN2B misc GRB2/7/10 misc CCCP misc exin type 6 misc Rac1 misc CoREST misc VPS10P misc Raf misc Akt, PKB misc Shank3 misc single-nucleotide polymorphism analysis misc neuronal cell adhesion molecule misc adaptor protein of the PDZ-LIM family misc Kv4.3 and KChip3 misc nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cells, transcription factor family with Rel homology domain (RHD) misc (Ras homolog) family of small GTPases including Cdc42, Rac1, and RhoA misc SHP-2 misc MAPK misc GDNF family receptor α misc CaMKIIβ misc PKA misc RRF misc PINK1 misc substantia nigra misc TIEG misc PTEN misc insulin receptor substrate 1, adaptor protein, contains a PTB and PH domain misc cAMP misc PACE4, PCSK6 misc dopamine transporter misc Ras misc glycosylphosphatidylinositol misc GFRα misc protein kinase A, a family of cAMP-dependent protein kinase misc son of sevenless, family of guanine nucleotide exchange factors that act on Ras misc (acronym combining the first letters of three proteins – Lin11, Isl-1 and Mec-3 – that have this common domain) protein interaction domain of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker misc phosphotyrosine-binding domains misc enhanced green fluorescent protein misc HIF-1a misc EGR1 misc Ser/Thr misc (Rat sarcoma) family of small membrane-associated GTPase misc (acronym combining the first letters of three proteins – post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1) that have this common domain) protein interaction domain |
topic_browse |
ddc 570 misc serine and threonine, which can be phosphorylated misc Parkinson disease misc SH3 and multiple ankyrin repeat domains 3, proline-rich synapse-associated protein 2 (ProSAP2) misc cycles between an active GTP-bound and an inactive GDP-bound state misc GABA misc glia cell line-derived neurotrophic factor misc Src misc (rapidly accelerated fibrosarcoma/rat fibrosarcoma) family of serine/threonine-protein kinase misc GDNF misc sensitive, voltage gated A-type K+ channel misc (sarcoma protein) membrane-associated tyrosine kinase with different Src homology (SH) domains characteristic for all 9 members of the Src family kinases misc tyrosines, which can be phosphorylated misc BDNF misc SHC misc Mouse model misc monoamine oxidases A and B misc hypoxia-inducible factor-1alpha misc growth factor receptor-bound protein 2, 7 and 10, adaptor proteins misc Enigma misc catechol-O-methyltransferase misc VTA misc Drug addiction misc pleckstrin homology domain misc FRS2 misc Ret misc γ-aminobutyric acid, inhibitory neurotransmitter in mammalian central nervous system misc protein kinase B, serine/threonine-specific protein kinase misc DAT misc phosphatase and tensin homolog misc MAOA/MAOB misc EGFP misc multiple endocrine neoplasia 2 type B, mutation in the kinase domain of the Ret leading to constitutive active receptor misc MPTP misc early growth response protein 1, Zif268 (zinc finger protein 225), NGFI-A (nerve growth factor-induced protein A), is a zinc finger transcription factor misc SorLA misc Cdc42 misc co-repressor for element-1-silencing transcription factor, a chromatin-modifying corepressor complex that acts with REST (repressor for element-1 silencing transcription factor) complex misc retro-rubal field misc calcium-calmodulin-dependent protein kinase II β isoform misc GFLs misc 6-OHDA misc GTPase-activating proteins 1 and 2 misc 3′,5′-cyclic adenosine monophosphate misc GDNF family of ligands misc monoamine, neurotransmitter type including dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline) misc FosB/ΔFosB misc NGF misc 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine misc glycogen synthase kinase 3β misc Rho misc carbonyl cyanide m-chlorophenyl hydrazone misc LIM misc TGF-β misc Tyr misc FBJ murine osteosarcoma viral oncogene homolog B, a transcription factor with a truncated Δ form misc JNK misc brain derived neurotrophic factor misc MEN2B misc GRB2/7/10 misc CCCP misc exin type 6 misc Rac1 misc CoREST misc VPS10P misc Raf misc Akt, PKB misc Shank3 misc single-nucleotide polymorphism analysis misc neuronal cell adhesion molecule misc adaptor protein of the PDZ-LIM family misc Kv4.3 and KChip3 misc nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cells, transcription factor family with Rel homology domain (RHD) misc (Ras homolog) family of small GTPases including Cdc42, Rac1, and RhoA misc SHP-2 misc MAPK misc GDNF family receptor α misc CaMKIIβ misc PKA misc RRF misc PINK1 misc substantia nigra misc TIEG misc PTEN misc insulin receptor substrate 1, adaptor protein, contains a PTB and PH domain misc cAMP misc PACE4, PCSK6 misc dopamine transporter misc Ras misc glycosylphosphatidylinositol misc GFRα misc protein kinase A, a family of cAMP-dependent protein kinase misc son of sevenless, family of guanine nucleotide exchange factors that act on Ras misc (acronym combining the first letters of three proteins – Lin11, Isl-1 and Mec-3 – that have this common domain) protein interaction domain of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker misc phosphotyrosine-binding domains misc enhanced green fluorescent protein misc HIF-1a misc EGR1 misc Ser/Thr misc (Rat sarcoma) family of small membrane-associated GTPase misc (acronym combining the first letters of three proteins – post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1) that have this common domain) protein interaction domain |
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GDNF–Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease |
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GDNF–Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease |
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gdnf–ret signaling in midbrain dopaminergic neurons and its implication for parkinson disease |
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GDNF–Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease |
abstract |
Glial cell line‐derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal together or independently to fulfill many important functions in the midbrain dopaminergic (DA) system. While Ret signaling clearly impacts on the development, maintenance and regeneration of the mesostriatal DA system, the physiological functions of GDNF for the DA system are still unclear. Nevertheless, GDNF is still considered to be an excellent candidate to protect and/or regenerate the mesostriatal DA system in Parkinson disease (PD). Clinical trials with GDNF on PD patients are, however, so far inconclusive. Here, we review the current knowledge of GDNF and Ret signaling and function in the midbrain DA system, and their crosstalk with proteins and signaling pathways associated with PD. |
abstractGer |
Glial cell line‐derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal together or independently to fulfill many important functions in the midbrain dopaminergic (DA) system. While Ret signaling clearly impacts on the development, maintenance and regeneration of the mesostriatal DA system, the physiological functions of GDNF for the DA system are still unclear. Nevertheless, GDNF is still considered to be an excellent candidate to protect and/or regenerate the mesostriatal DA system in Parkinson disease (PD). Clinical trials with GDNF on PD patients are, however, so far inconclusive. Here, we review the current knowledge of GDNF and Ret signaling and function in the midbrain DA system, and their crosstalk with proteins and signaling pathways associated with PD. |
abstract_unstemmed |
Glial cell line‐derived neurotrophic factor (GDNF) and its canonical receptor Ret can signal together or independently to fulfill many important functions in the midbrain dopaminergic (DA) system. While Ret signaling clearly impacts on the development, maintenance and regeneration of the mesostriatal DA system, the physiological functions of GDNF for the DA system are still unclear. Nevertheless, GDNF is still considered to be an excellent candidate to protect and/or regenerate the mesostriatal DA system in Parkinson disease (PD). Clinical trials with GDNF on PD patients are, however, so far inconclusive. Here, we review the current knowledge of GDNF and Ret signaling and function in the midbrain DA system, and their crosstalk with proteins and signaling pathways associated with PD. |
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title_short |
GDNF–Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease |
url |
http://dx.doi.org/10.1016/j.febslet.2015.11.006 http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2015.11.006/abstract http://www.ncbi.nlm.nih.gov/pubmed/26555190 |
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tag="650" ind1=" " ind2="4"><subfield code="a">HIF-1a</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">EGR1</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Ser/Thr</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">(Rat sarcoma) family of small membrane-associated GTPase</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">(acronym combining the first letters of three proteins – post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1) that have this common domain) protein interaction domain</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Liss, Birgit</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">FEBS letters</subfield><subfield code="d">Amsterdam [u.a.] : Elsevier, 1968</subfield><subfield code="g">589(2015), 24PartA, Seite 3760-3772</subfield><subfield code="w">(DE-627)129522023</subfield><subfield code="w">(DE-600)212746-5</subfield><subfield code="w">(DE-576)014938014</subfield><subfield code="x">0014-5793</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:589</subfield><subfield code="g">year:2015</subfield><subfield code="g">number:24PartA</subfield><subfield code="g">pages:3760-3772</subfield></datafield><datafield tag="856" ind1="4" ind2="1"><subfield code="u">http://dx.doi.org/10.1016/j.febslet.2015.11.006</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2015.11.006/abstract</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">http://www.ncbi.nlm.nih.gov/pubmed/26555190</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_OLC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHY</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-CHE</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-DE-84</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_21</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_211</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2219</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4219</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">589</subfield><subfield code="j">2015</subfield><subfield code="e">24PartA</subfield><subfield code="h">3760-3772</subfield></datafield></record></collection>
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