Mutagenesis. Smoking is associated with mosaic loss of chromosome Y

Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared with females. This observation, together with the fact that males have a h...
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Autor*in:	Dumanski, Jan P [verfasserIn] Rasi, Chiara Lönn, Mikael Davies, Hanna Ingelsson, Martin Giedraitis, Vilmantas Lannfelt, Lars Magnusson, Patrik K E Lindgren, Cecilia M Morris, Andrew P Cesarini, David Johannesson, Magnus Tiensuu Janson, Eva Lind, Lars Pedersen, Nancy L Ingelsson, Erik Forsberg, Lars A

Format:	Artikel
Sprache:	Englisch

Erschienen:	2015

Rechteinformationen:	Nutzungsrecht: Copyright © 2015, American Association for the Advancement of Science.

Schlagwörter:	Lung Neoplasms - genetics Blood Cells - metabolism Lung Neoplasms - epidemiology Chromosomes, Human, Y - genetics

Übergeordnetes Werk:	Enthalten in: Science - Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883, 347(2015), 6217, Seite 81
Übergeordnetes Werk:	volume:347 ; year:2015 ; number:6217 ; pages:81

Links:	Link aufrufen Link aufrufen

Katalog-ID:	OLC1966820984

Internformat


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520			\|a Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared with females. This observation, together with the fact that males have a higher incidence of and mortality from most non-sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We demonstrate here that smoking is associated with LOY in blood cells in three independent cohorts [TwinGene: odds ratio (OR) = 4.3, 95% confidence interval (CI) = 2.8 to 6.7; Uppsala Longitudinal Study of Adult Men: OR = 2.4, 95% CI = 1.6 to 3.6; and Prospective Investigation of the Vasculature in Uppsala Seniors: OR = 3.5, 95% CI = 1.4 to 8.4] encompassing a total of 6014 men. The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking induces LOY thus links a preventable risk factor with the most common acquired human mutation.
540			\|a Nutzungsrecht: Copyright © 2015, American Association for the Advancement of Science.
650		4	\|a Lung Neoplasms - genetics
650		4	\|a Blood Cells - metabolism
650		4	\|a Lung Neoplasms - epidemiology
650		4	\|a Chromosomes, Human, Y - genetics
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700	1		\|a Ingelsson, Martin \|4 oth
700	1		\|a Giedraitis, Vilmantas \|4 oth
700	1		\|a Lannfelt, Lars \|4 oth
700	1		\|a Magnusson, Patrik K E \|4 oth
700	1		\|a Lindgren, Cecilia M \|4 oth
700	1		\|a Morris, Andrew P \|4 oth
700	1		\|a Cesarini, David \|4 oth
700	1		\|a Johannesson, Magnus \|4 oth
700	1		\|a Tiensuu Janson, Eva \|4 oth
700	1		\|a Lind, Lars \|4 oth
700	1		\|a Pedersen, Nancy L \|4 oth
700	1		\|a Ingelsson, Erik \|4 oth
700	1		\|a Forsberg, Lars A \|4 oth
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author_variant	j p d jp jpd
matchkey_str	article:00368075:2015----::uaeeisoigssoitdihoaco
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publishDate	2015
allfields	PQ20160617 (DE-627)OLC1966820984 (DE-599)GBVOLC1966820984 (PRQ)p1407-d0daabe677b63ead9dbf8656d9db6093ef630ae58039cd559a57cd3e33c86fb40 (KEY)0063888920150000347621700081mutagenesissmokingisassociatedwithmosaiclossofchro DE-627 ger DE-627 rakwb eng 500 DNB LING fid Dumanski, Jan P verfasserin aut Mutagenesis. Smoking is associated with mosaic loss of chromosome Y 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared with females. This observation, together with the fact that males have a higher incidence of and mortality from most non-sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We demonstrate here that smoking is associated with LOY in blood cells in three independent cohorts [TwinGene: odds ratio (OR) = 4.3, 95% confidence interval (CI) = 2.8 to 6.7; Uppsala Longitudinal Study of Adult Men: OR = 2.4, 95% CI = 1.6 to 3.6; and Prospective Investigation of the Vasculature in Uppsala Seniors: OR = 3.5, 95% CI = 1.4 to 8.4] encompassing a total of 6014 men. The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking induces LOY thus links a preventable risk factor with the most common acquired human mutation. Nutzungsrecht: Copyright © 2015, American Association for the Advancement of Science. Lung Neoplasms - genetics Blood Cells - metabolism Lung Neoplasms - epidemiology Chromosomes, Human, Y - genetics Rasi, Chiara oth Lönn, Mikael oth Davies, Hanna oth Ingelsson, Martin oth Giedraitis, Vilmantas oth Lannfelt, Lars oth Magnusson, Patrik K E oth Lindgren, Cecilia M oth Morris, Andrew P oth Cesarini, David oth Johannesson, Magnus oth Tiensuu Janson, Eva oth Lind, Lars oth Pedersen, Nancy L oth Ingelsson, Erik oth Forsberg, Lars A oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 347(2015), 6217, Seite 81 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:347 year:2015 number:6217 pages:81 http://www.ncbi.nlm.nih.gov/pubmed/25477213 http://kipublications.ki.se/Default.aspx?queryparsed=id:130420087 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2185 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 347 2015 6217 81
spelling	PQ20160617 (DE-627)OLC1966820984 (DE-599)GBVOLC1966820984 (PRQ)p1407-d0daabe677b63ead9dbf8656d9db6093ef630ae58039cd559a57cd3e33c86fb40 (KEY)0063888920150000347621700081mutagenesissmokingisassociatedwithmosaiclossofchro DE-627 ger DE-627 rakwb eng 500 DNB LING fid Dumanski, Jan P verfasserin aut Mutagenesis. Smoking is associated with mosaic loss of chromosome Y 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared with females. This observation, together with the fact that males have a higher incidence of and mortality from most non-sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We demonstrate here that smoking is associated with LOY in blood cells in three independent cohorts [TwinGene: odds ratio (OR) = 4.3, 95% confidence interval (CI) = 2.8 to 6.7; Uppsala Longitudinal Study of Adult Men: OR = 2.4, 95% CI = 1.6 to 3.6; and Prospective Investigation of the Vasculature in Uppsala Seniors: OR = 3.5, 95% CI = 1.4 to 8.4] encompassing a total of 6014 men. The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking induces LOY thus links a preventable risk factor with the most common acquired human mutation. Nutzungsrecht: Copyright © 2015, American Association for the Advancement of Science. Lung Neoplasms - genetics Blood Cells - metabolism Lung Neoplasms - epidemiology Chromosomes, Human, Y - genetics Rasi, Chiara oth Lönn, Mikael oth Davies, Hanna oth Ingelsson, Martin oth Giedraitis, Vilmantas oth Lannfelt, Lars oth Magnusson, Patrik K E oth Lindgren, Cecilia M oth Morris, Andrew P oth Cesarini, David oth Johannesson, Magnus oth Tiensuu Janson, Eva oth Lind, Lars oth Pedersen, Nancy L oth Ingelsson, Erik oth Forsberg, Lars A oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 347(2015), 6217, Seite 81 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:347 year:2015 number:6217 pages:81 http://www.ncbi.nlm.nih.gov/pubmed/25477213 http://kipublications.ki.se/Default.aspx?queryparsed=id:130420087 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2185 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 347 2015 6217 81
allfields_unstemmed	PQ20160617 (DE-627)OLC1966820984 (DE-599)GBVOLC1966820984 (PRQ)p1407-d0daabe677b63ead9dbf8656d9db6093ef630ae58039cd559a57cd3e33c86fb40 (KEY)0063888920150000347621700081mutagenesissmokingisassociatedwithmosaiclossofchro DE-627 ger DE-627 rakwb eng 500 DNB LING fid Dumanski, Jan P verfasserin aut Mutagenesis. Smoking is associated with mosaic loss of chromosome Y 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared with females. This observation, together with the fact that males have a higher incidence of and mortality from most non-sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We demonstrate here that smoking is associated with LOY in blood cells in three independent cohorts [TwinGene: odds ratio (OR) = 4.3, 95% confidence interval (CI) = 2.8 to 6.7; Uppsala Longitudinal Study of Adult Men: OR = 2.4, 95% CI = 1.6 to 3.6; and Prospective Investigation of the Vasculature in Uppsala Seniors: OR = 3.5, 95% CI = 1.4 to 8.4] encompassing a total of 6014 men. The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking induces LOY thus links a preventable risk factor with the most common acquired human mutation. Nutzungsrecht: Copyright © 2015, American Association for the Advancement of Science. Lung Neoplasms - genetics Blood Cells - metabolism Lung Neoplasms - epidemiology Chromosomes, Human, Y - genetics Rasi, Chiara oth Lönn, Mikael oth Davies, Hanna oth Ingelsson, Martin oth Giedraitis, Vilmantas oth Lannfelt, Lars oth Magnusson, Patrik K E oth Lindgren, Cecilia M oth Morris, Andrew P oth Cesarini, David oth Johannesson, Magnus oth Tiensuu Janson, Eva oth Lind, Lars oth Pedersen, Nancy L oth Ingelsson, Erik oth Forsberg, Lars A oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 347(2015), 6217, Seite 81 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:347 year:2015 number:6217 pages:81 http://www.ncbi.nlm.nih.gov/pubmed/25477213 http://kipublications.ki.se/Default.aspx?queryparsed=id:130420087 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2185 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 347 2015 6217 81
allfieldsGer	PQ20160617 (DE-627)OLC1966820984 (DE-599)GBVOLC1966820984 (PRQ)p1407-d0daabe677b63ead9dbf8656d9db6093ef630ae58039cd559a57cd3e33c86fb40 (KEY)0063888920150000347621700081mutagenesissmokingisassociatedwithmosaiclossofchro DE-627 ger DE-627 rakwb eng 500 DNB LING fid Dumanski, Jan P verfasserin aut Mutagenesis. Smoking is associated with mosaic loss of chromosome Y 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared with females. This observation, together with the fact that males have a higher incidence of and mortality from most non-sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We demonstrate here that smoking is associated with LOY in blood cells in three independent cohorts [TwinGene: odds ratio (OR) = 4.3, 95% confidence interval (CI) = 2.8 to 6.7; Uppsala Longitudinal Study of Adult Men: OR = 2.4, 95% CI = 1.6 to 3.6; and Prospective Investigation of the Vasculature in Uppsala Seniors: OR = 3.5, 95% CI = 1.4 to 8.4] encompassing a total of 6014 men. The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking induces LOY thus links a preventable risk factor with the most common acquired human mutation. Nutzungsrecht: Copyright © 2015, American Association for the Advancement of Science. Lung Neoplasms - genetics Blood Cells - metabolism Lung Neoplasms - epidemiology Chromosomes, Human, Y - genetics Rasi, Chiara oth Lönn, Mikael oth Davies, Hanna oth Ingelsson, Martin oth Giedraitis, Vilmantas oth Lannfelt, Lars oth Magnusson, Patrik K E oth Lindgren, Cecilia M oth Morris, Andrew P oth Cesarini, David oth Johannesson, Magnus oth Tiensuu Janson, Eva oth Lind, Lars oth Pedersen, Nancy L oth Ingelsson, Erik oth Forsberg, Lars A oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 347(2015), 6217, Seite 81 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:347 year:2015 number:6217 pages:81 http://www.ncbi.nlm.nih.gov/pubmed/25477213 http://kipublications.ki.se/Default.aspx?queryparsed=id:130420087 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2185 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 347 2015 6217 81
allfieldsSound	PQ20160617 (DE-627)OLC1966820984 (DE-599)GBVOLC1966820984 (PRQ)p1407-d0daabe677b63ead9dbf8656d9db6093ef630ae58039cd559a57cd3e33c86fb40 (KEY)0063888920150000347621700081mutagenesissmokingisassociatedwithmosaiclossofchro DE-627 ger DE-627 rakwb eng 500 DNB LING fid Dumanski, Jan P verfasserin aut Mutagenesis. Smoking is associated with mosaic loss of chromosome Y 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared with females. This observation, together with the fact that males have a higher incidence of and mortality from most non-sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We demonstrate here that smoking is associated with LOY in blood cells in three independent cohorts [TwinGene: odds ratio (OR) = 4.3, 95% confidence interval (CI) = 2.8 to 6.7; Uppsala Longitudinal Study of Adult Men: OR = 2.4, 95% CI = 1.6 to 3.6; and Prospective Investigation of the Vasculature in Uppsala Seniors: OR = 3.5, 95% CI = 1.4 to 8.4] encompassing a total of 6014 men. The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking induces LOY thus links a preventable risk factor with the most common acquired human mutation. Nutzungsrecht: Copyright © 2015, American Association for the Advancement of Science. Lung Neoplasms - genetics Blood Cells - metabolism Lung Neoplasms - epidemiology Chromosomes, Human, Y - genetics Rasi, Chiara oth Lönn, Mikael oth Davies, Hanna oth Ingelsson, Martin oth Giedraitis, Vilmantas oth Lannfelt, Lars oth Magnusson, Patrik K E oth Lindgren, Cecilia M oth Morris, Andrew P oth Cesarini, David oth Johannesson, Magnus oth Tiensuu Janson, Eva oth Lind, Lars oth Pedersen, Nancy L oth Ingelsson, Erik oth Forsberg, Lars A oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 347(2015), 6217, Seite 81 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:347 year:2015 number:6217 pages:81 http://www.ncbi.nlm.nih.gov/pubmed/25477213 http://kipublications.ki.se/Default.aspx?queryparsed=id:130420087 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2185 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 347 2015 6217 81
language	English
source	Enthalten in Science 347(2015), 6217, Seite 81 volume:347 year:2015 number:6217 pages:81
sourceStr	Enthalten in Science 347(2015), 6217, Seite 81 volume:347 year:2015 number:6217 pages:81
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Lung Neoplasms - genetics Blood Cells - metabolism Lung Neoplasms - epidemiology Chromosomes, Human, Y - genetics
dewey-raw	500
isfreeaccess_bool	false
container_title	Science
authorswithroles_txt_mv	Dumanski, Jan P @@aut@@ Rasi, Chiara @@oth@@ Lönn, Mikael @@oth@@ Davies, Hanna @@oth@@ Ingelsson, Martin @@oth@@ Giedraitis, Vilmantas @@oth@@ Lannfelt, Lars @@oth@@ Magnusson, Patrik K E @@oth@@ Lindgren, Cecilia M @@oth@@ Morris, Andrew P @@oth@@ Cesarini, David @@oth@@ Johannesson, Magnus @@oth@@ Tiensuu Janson, Eva @@oth@@ Lind, Lars @@oth@@ Pedersen, Nancy L @@oth@@ Ingelsson, Erik @@oth@@ Forsberg, Lars A @@oth@@
publishDateDaySort_date	2015-01-01T00:00:00Z
hierarchy_top_id	12931482X
dewey-sort	3500
id	OLC1966820984
language_de	englisch
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author	Dumanski, Jan P
spellingShingle	Dumanski, Jan P ddc 500 fid LING misc Lung Neoplasms - genetics misc Blood Cells - metabolism misc Lung Neoplasms - epidemiology misc Chromosomes, Human, Y - genetics Mutagenesis. Smoking is associated with mosaic loss of chromosome Y
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topic_title	500 DNB LING fid Mutagenesis. Smoking is associated with mosaic loss of chromosome Y Lung Neoplasms - genetics Blood Cells - metabolism Lung Neoplasms - epidemiology Chromosomes, Human, Y - genetics
topic	ddc 500 fid LING misc Lung Neoplasms - genetics misc Blood Cells - metabolism misc Lung Neoplasms - epidemiology misc Chromosomes, Human, Y - genetics
topic_unstemmed	ddc 500 fid LING misc Lung Neoplasms - genetics misc Blood Cells - metabolism misc Lung Neoplasms - epidemiology misc Chromosomes, Human, Y - genetics
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title	Mutagenesis. Smoking is associated with mosaic loss of chromosome Y
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title_full	Mutagenesis. Smoking is associated with mosaic loss of chromosome Y
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title_sort	mutagenesis. smoking is associated with mosaic loss of chromosome y
title_auth	Mutagenesis. Smoking is associated with mosaic loss of chromosome Y
abstract	Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared with females. This observation, together with the fact that males have a higher incidence of and mortality from most non-sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We demonstrate here that smoking is associated with LOY in blood cells in three independent cohorts [TwinGene: odds ratio (OR) = 4.3, 95% confidence interval (CI) = 2.8 to 6.7; Uppsala Longitudinal Study of Adult Men: OR = 2.4, 95% CI = 1.6 to 3.6; and Prospective Investigation of the Vasculature in Uppsala Seniors: OR = 3.5, 95% CI = 1.4 to 8.4] encompassing a total of 6014 men. The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking induces LOY thus links a preventable risk factor with the most common acquired human mutation.
abstractGer	Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared with females. This observation, together with the fact that males have a higher incidence of and mortality from most non-sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We demonstrate here that smoking is associated with LOY in blood cells in three independent cohorts [TwinGene: odds ratio (OR) = 4.3, 95% confidence interval (CI) = 2.8 to 6.7; Uppsala Longitudinal Study of Adult Men: OR = 2.4, 95% CI = 1.6 to 3.6; and Prospective Investigation of the Vasculature in Uppsala Seniors: OR = 3.5, 95% CI = 1.4 to 8.4] encompassing a total of 6014 men. The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking induces LOY thus links a preventable risk factor with the most common acquired human mutation.
abstract_unstemmed	Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared with females. This observation, together with the fact that males have a higher incidence of and mortality from most non-sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We demonstrate here that smoking is associated with LOY in blood cells in three independent cohorts [TwinGene: odds ratio (OR) = 4.3, 95% confidence interval (CI) = 2.8 to 6.7; Uppsala Longitudinal Study of Adult Men: OR = 2.4, 95% CI = 1.6 to 3.6; and Prospective Investigation of the Vasculature in Uppsala Seniors: OR = 3.5, 95% CI = 1.4 to 8.4] encompassing a total of 6014 men. The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking induces LOY thus links a preventable risk factor with the most common acquired human mutation.
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title_short	Mutagenesis. Smoking is associated with mosaic loss of chromosome Y
url	http://www.ncbi.nlm.nih.gov/pubmed/25477213 http://kipublications.ki.se/Default.aspx?queryparsed=id:130420087
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Smoking is associated with mosaic loss of chromosome Y</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2015</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">ohne Hilfsmittel zu benutzen</subfield><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Band</subfield><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared with females. This observation, together with the fact that males have a higher incidence of and mortality from most non-sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We demonstrate here that smoking is associated with LOY in blood cells in three independent cohorts [TwinGene: odds ratio (OR) = 4.3, 95% confidence interval (CI) = 2.8 to 6.7; Uppsala Longitudinal Study of Adult Men: OR = 2.4, 95% CI = 1.6 to 3.6; and Prospective Investigation of the Vasculature in Uppsala Seniors: OR = 3.5, 95% CI = 1.4 to 8.4] encompassing a total of 6014 men. The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking induces LOY thus links a preventable risk factor with the most common acquired human mutation.</subfield></datafield><datafield tag="540" ind1=" " ind2=" "><subfield code="a">Nutzungsrecht: Copyright © 2015, American Association for the Advancement of Science.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Lung Neoplasms - genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Blood Cells - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Lung Neoplasms - epidemiology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Chromosomes, Human, Y - genetics</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Rasi, Chiara</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lönn, Mikael</subfield><subfield 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Mutagenesis. Smoking is associated with mosaic loss of chromosome Y

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