Inhibitory Effects of Extract from G. lanceolata on LPS-Induced Production of Nitric Oxide and IL-1β via Down-regulation of MAPK in Macrophages
Grateloupia lanceolata is a red alga native to coastal areas of East Asia. In this study, extract from G. lanceolata (EGL) was investigated for suppressive effects on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages. EGL was found to have anti-inflammatory properties...
Ausführliche Beschreibung
Autor*in: |
Kim, Dong Hwan [verfasserIn] |
---|
Format: |
Artikel |
---|---|
Sprache: |
Englisch |
Erschienen: |
2015 |
---|
Rechteinformationen: |
Nutzungsrecht: © Springer Science+Business Media New York 2015 |
---|
Übergeordnetes Werk: |
Enthalten in: Applied biochemistry and biotechnology / A - New York, NY : Springer, 1994, 175(2015), 2, Seite 657-665 |
---|---|
Übergeordnetes Werk: |
volume:175 ; year:2015 ; number:2 ; pages:657-665 |
Links: |
---|
DOI / URN: |
10.1007/s12010-014-1301-8 |
---|
Katalog-ID: |
OLC1967120846 |
---|
LEADER | 01000caa a2200265 4500 | ||
---|---|---|---|
001 | OLC1967120846 | ||
003 | DE-627 | ||
005 | 20220221022429.0 | ||
007 | tu | ||
008 | 160206s2015 xx ||||| 00| ||eng c | ||
024 | 7 | |a 10.1007/s12010-014-1301-8 |2 doi | |
028 | 5 | 2 | |a PQ20160617 |
035 | |a (DE-627)OLC1967120846 | ||
035 | |a (DE-599)GBVOLC1967120846 | ||
035 | |a (PRQ)c1922-6164b92e85c5a8ceb60008020e85c47f4b9bca9fac3042c1e44ca8f9a7e8a02a0 | ||
035 | |a (KEY)0068751020150000175000200657inhibitoryeffectsofextractfromglanceolataonlpsindu | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
082 | 0 | 4 | |a 570 |a 540 |a 660 |q DNB |
084 | |a 42.00 |2 bkl | ||
100 | 1 | |a Kim, Dong Hwan |e verfasserin |4 aut | |
245 | 1 | 0 | |a Inhibitory Effects of Extract from G. lanceolata on LPS-Induced Production of Nitric Oxide and IL-1β via Down-regulation of MAPK in Macrophages |
264 | 1 | |c 2015 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
338 | |a Band |b nc |2 rdacarrier | ||
520 | |a Grateloupia lanceolata is a red alga native to coastal areas of East Asia. In this study, extract from G. lanceolata (EGL) was investigated for suppressive effects on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages. EGL was found to have anti-inflammatory properties with the inhibition of nitric oxide (NO), pro-inflammatory cytokine production, and MAPK signaling in LPS-induced RAW 264.7 macrophages. Moreover, treatment of RAW 264.7 macrophage with EGL inhibited LPS-induced IL-1β production in a dose-dependent manner. These inhibitory effects were found with the blockage of p38 mitogen-activated protein kinases (MAPK), extracellular signal regulated kinases 1 and 2 (ERK1/2), and also c-Jun N-terminal kinases 1 and 2 (JNK1/2). These results indicated that anti-inflammatory actions of EGL in RAW 264.7 macrophages involved in the inhibition of LPS-induced p38MAPK/ERK/JNK signaling pathways. In addition, our findings suggest that EGL holds great promise for use in the treatment of various inflammatory diseases. | ||
540 | |a Nutzungsrecht: © Springer Science+Business Media New York 2015 | ||
650 | 4 | |a Biochemistry, general | |
650 | 4 | |a Chemistry | |
650 | 4 | |a Macrophage | |
650 | 4 | |a MAPK signaling | |
650 | 4 | |a Extract from Grateloupia lanceolata | |
650 | 4 | |a Biotechnology | |
650 | 4 | |a Inflammation | |
650 | 4 | |a Rhodophyta - chemistry | |
650 | 4 | |a Interleukin-1beta - antagonists & inhibitors | |
650 | 4 | |a Macrophages - cytology | |
650 | 4 | |a Plant Extracts - pharmacology | |
650 | 4 | |a Mitogen-Activated Protein Kinase 1 - genetics | |
650 | 4 | |a Interleukin-1beta - metabolism | |
650 | 4 | |a Mitogen-Activated Protein Kinase 1 - metabolism | |
650 | 4 | |a Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | |
650 | 4 | |a Macrophages - drug effects | |
650 | 4 | |a Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors | |
650 | 4 | |a Nitric Oxide - biosynthesis | |
650 | 4 | |a Lipopolysaccharides - antagonists & inhibitors | |
650 | 4 | |a Anti-Inflammatory Agents - chemistry | |
650 | 4 | |a p38 Mitogen-Activated Protein Kinases - metabolism | |
650 | 4 | |a Mitogen-Activated Protein Kinase 3 - genetics | |
650 | 4 | |a Mitogen-Activated Protein Kinase 8 - genetics | |
650 | 4 | |a Nitric Oxide - antagonists & inhibitors | |
650 | 4 | |a Mitogen-Activated Protein Kinase 8 - metabolism | |
650 | 4 | |a Plant Extracts - chemistry | |
650 | 4 | |a Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors | |
650 | 4 | |a Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | |
650 | 4 | |a Macrophages - metabolism | |
650 | 4 | |a Mitogen-Activated Protein Kinase 9 - genetics | |
650 | 4 | |a p38 Mitogen-Activated Protein Kinases - genetics | |
650 | 4 | |a Mitogen-Activated Protein Kinase 3 - metabolism | |
650 | 4 | |a Anti-Inflammatory Agents - pharmacology | |
650 | 4 | |a p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | |
650 | 4 | |a Interleukin-1beta - genetics | |
650 | 4 | |a Mitogen-Activated Protein Kinase 9 - metabolism | |
650 | 4 | |a Lipopolysaccharides - pharmacology | |
700 | 1 | |a Kim, Mi Eun |4 oth | |
700 | 1 | |a Lee, Jun Sik |4 oth | |
773 | 0 | 8 | |i Enthalten in |t Applied biochemistry and biotechnology / A |d New York, NY : Springer, 1994 |g 175(2015), 2, Seite 657-665 |w (DE-627)182278573 |w (DE-600)1193054-8 |w (DE-576)043085105 |x 0273-2289 |7 nnns |
773 | 1 | 8 | |g volume:175 |g year:2015 |g number:2 |g pages:657-665 |
856 | 4 | 1 | |u http://dx.doi.org/10.1007/s12010-014-1301-8 |3 Volltext |
856 | 4 | 2 | |u http://www.ncbi.nlm.nih.gov/pubmed/25342257 |
912 | |a GBV_USEFLAG_A | ||
912 | |a SYSFLAG_A | ||
912 | |a GBV_OLC | ||
912 | |a SSG-OLC-TEC | ||
912 | |a SSG-OLC-CHE | ||
912 | |a GBV_ILN_70 | ||
912 | |a GBV_ILN_4012 | ||
936 | b | k | |a 42.00 |q AVZ |
951 | |a AR | ||
952 | |d 175 |j 2015 |e 2 |h 657-665 |
author_variant |
d h k dh dhk |
---|---|
matchkey_str |
article:02732289:2015----::niioyfetoetatrmlneltolsnuepoutoontioieni1id |
hierarchy_sort_str |
2015 |
bklnumber |
42.00 |
publishDate |
2015 |
allfields |
10.1007/s12010-014-1301-8 doi PQ20160617 (DE-627)OLC1967120846 (DE-599)GBVOLC1967120846 (PRQ)c1922-6164b92e85c5a8ceb60008020e85c47f4b9bca9fac3042c1e44ca8f9a7e8a02a0 (KEY)0068751020150000175000200657inhibitoryeffectsofextractfromglanceolataonlpsindu DE-627 ger DE-627 rakwb eng 570 540 660 DNB 42.00 bkl Kim, Dong Hwan verfasserin aut Inhibitory Effects of Extract from G. lanceolata on LPS-Induced Production of Nitric Oxide and IL-1β via Down-regulation of MAPK in Macrophages 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Grateloupia lanceolata is a red alga native to coastal areas of East Asia. In this study, extract from G. lanceolata (EGL) was investigated for suppressive effects on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages. EGL was found to have anti-inflammatory properties with the inhibition of nitric oxide (NO), pro-inflammatory cytokine production, and MAPK signaling in LPS-induced RAW 264.7 macrophages. Moreover, treatment of RAW 264.7 macrophage with EGL inhibited LPS-induced IL-1β production in a dose-dependent manner. These inhibitory effects were found with the blockage of p38 mitogen-activated protein kinases (MAPK), extracellular signal regulated kinases 1 and 2 (ERK1/2), and also c-Jun N-terminal kinases 1 and 2 (JNK1/2). These results indicated that anti-inflammatory actions of EGL in RAW 264.7 macrophages involved in the inhibition of LPS-induced p38MAPK/ERK/JNK signaling pathways. In addition, our findings suggest that EGL holds great promise for use in the treatment of various inflammatory diseases. Nutzungsrecht: © Springer Science+Business Media New York 2015 Biochemistry, general Chemistry Macrophage MAPK signaling Extract from Grateloupia lanceolata Biotechnology Inflammation Rhodophyta - chemistry Interleukin-1beta - antagonists & inhibitors Macrophages - cytology Plant Extracts - pharmacology Mitogen-Activated Protein Kinase 1 - genetics Interleukin-1beta - metabolism Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors Macrophages - drug effects Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors Nitric Oxide - biosynthesis Lipopolysaccharides - antagonists & inhibitors Anti-Inflammatory Agents - chemistry p38 Mitogen-Activated Protein Kinases - metabolism Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 8 - genetics Nitric Oxide - antagonists & inhibitors Mitogen-Activated Protein Kinase 8 - metabolism Plant Extracts - chemistry Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors Macrophages - metabolism Mitogen-Activated Protein Kinase 9 - genetics p38 Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinase 3 - metabolism Anti-Inflammatory Agents - pharmacology p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors Interleukin-1beta - genetics Mitogen-Activated Protein Kinase 9 - metabolism Lipopolysaccharides - pharmacology Kim, Mi Eun oth Lee, Jun Sik oth Enthalten in Applied biochemistry and biotechnology / A New York, NY : Springer, 1994 175(2015), 2, Seite 657-665 (DE-627)182278573 (DE-600)1193054-8 (DE-576)043085105 0273-2289 nnns volume:175 year:2015 number:2 pages:657-665 http://dx.doi.org/10.1007/s12010-014-1301-8 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25342257 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 GBV_ILN_4012 42.00 AVZ AR 175 2015 2 657-665 |
spelling |
10.1007/s12010-014-1301-8 doi PQ20160617 (DE-627)OLC1967120846 (DE-599)GBVOLC1967120846 (PRQ)c1922-6164b92e85c5a8ceb60008020e85c47f4b9bca9fac3042c1e44ca8f9a7e8a02a0 (KEY)0068751020150000175000200657inhibitoryeffectsofextractfromglanceolataonlpsindu DE-627 ger DE-627 rakwb eng 570 540 660 DNB 42.00 bkl Kim, Dong Hwan verfasserin aut Inhibitory Effects of Extract from G. lanceolata on LPS-Induced Production of Nitric Oxide and IL-1β via Down-regulation of MAPK in Macrophages 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Grateloupia lanceolata is a red alga native to coastal areas of East Asia. In this study, extract from G. lanceolata (EGL) was investigated for suppressive effects on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages. EGL was found to have anti-inflammatory properties with the inhibition of nitric oxide (NO), pro-inflammatory cytokine production, and MAPK signaling in LPS-induced RAW 264.7 macrophages. Moreover, treatment of RAW 264.7 macrophage with EGL inhibited LPS-induced IL-1β production in a dose-dependent manner. These inhibitory effects were found with the blockage of p38 mitogen-activated protein kinases (MAPK), extracellular signal regulated kinases 1 and 2 (ERK1/2), and also c-Jun N-terminal kinases 1 and 2 (JNK1/2). These results indicated that anti-inflammatory actions of EGL in RAW 264.7 macrophages involved in the inhibition of LPS-induced p38MAPK/ERK/JNK signaling pathways. In addition, our findings suggest that EGL holds great promise for use in the treatment of various inflammatory diseases. Nutzungsrecht: © Springer Science+Business Media New York 2015 Biochemistry, general Chemistry Macrophage MAPK signaling Extract from Grateloupia lanceolata Biotechnology Inflammation Rhodophyta - chemistry Interleukin-1beta - antagonists & inhibitors Macrophages - cytology Plant Extracts - pharmacology Mitogen-Activated Protein Kinase 1 - genetics Interleukin-1beta - metabolism Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors Macrophages - drug effects Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors Nitric Oxide - biosynthesis Lipopolysaccharides - antagonists & inhibitors Anti-Inflammatory Agents - chemistry p38 Mitogen-Activated Protein Kinases - metabolism Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 8 - genetics Nitric Oxide - antagonists & inhibitors Mitogen-Activated Protein Kinase 8 - metabolism Plant Extracts - chemistry Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors Macrophages - metabolism Mitogen-Activated Protein Kinase 9 - genetics p38 Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinase 3 - metabolism Anti-Inflammatory Agents - pharmacology p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors Interleukin-1beta - genetics Mitogen-Activated Protein Kinase 9 - metabolism Lipopolysaccharides - pharmacology Kim, Mi Eun oth Lee, Jun Sik oth Enthalten in Applied biochemistry and biotechnology / A New York, NY : Springer, 1994 175(2015), 2, Seite 657-665 (DE-627)182278573 (DE-600)1193054-8 (DE-576)043085105 0273-2289 nnns volume:175 year:2015 number:2 pages:657-665 http://dx.doi.org/10.1007/s12010-014-1301-8 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25342257 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 GBV_ILN_4012 42.00 AVZ AR 175 2015 2 657-665 |
allfields_unstemmed |
10.1007/s12010-014-1301-8 doi PQ20160617 (DE-627)OLC1967120846 (DE-599)GBVOLC1967120846 (PRQ)c1922-6164b92e85c5a8ceb60008020e85c47f4b9bca9fac3042c1e44ca8f9a7e8a02a0 (KEY)0068751020150000175000200657inhibitoryeffectsofextractfromglanceolataonlpsindu DE-627 ger DE-627 rakwb eng 570 540 660 DNB 42.00 bkl Kim, Dong Hwan verfasserin aut Inhibitory Effects of Extract from G. lanceolata on LPS-Induced Production of Nitric Oxide and IL-1β via Down-regulation of MAPK in Macrophages 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Grateloupia lanceolata is a red alga native to coastal areas of East Asia. In this study, extract from G. lanceolata (EGL) was investigated for suppressive effects on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages. EGL was found to have anti-inflammatory properties with the inhibition of nitric oxide (NO), pro-inflammatory cytokine production, and MAPK signaling in LPS-induced RAW 264.7 macrophages. Moreover, treatment of RAW 264.7 macrophage with EGL inhibited LPS-induced IL-1β production in a dose-dependent manner. These inhibitory effects were found with the blockage of p38 mitogen-activated protein kinases (MAPK), extracellular signal regulated kinases 1 and 2 (ERK1/2), and also c-Jun N-terminal kinases 1 and 2 (JNK1/2). These results indicated that anti-inflammatory actions of EGL in RAW 264.7 macrophages involved in the inhibition of LPS-induced p38MAPK/ERK/JNK signaling pathways. In addition, our findings suggest that EGL holds great promise for use in the treatment of various inflammatory diseases. Nutzungsrecht: © Springer Science+Business Media New York 2015 Biochemistry, general Chemistry Macrophage MAPK signaling Extract from Grateloupia lanceolata Biotechnology Inflammation Rhodophyta - chemistry Interleukin-1beta - antagonists & inhibitors Macrophages - cytology Plant Extracts - pharmacology Mitogen-Activated Protein Kinase 1 - genetics Interleukin-1beta - metabolism Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors Macrophages - drug effects Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors Nitric Oxide - biosynthesis Lipopolysaccharides - antagonists & inhibitors Anti-Inflammatory Agents - chemistry p38 Mitogen-Activated Protein Kinases - metabolism Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 8 - genetics Nitric Oxide - antagonists & inhibitors Mitogen-Activated Protein Kinase 8 - metabolism Plant Extracts - chemistry Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors Macrophages - metabolism Mitogen-Activated Protein Kinase 9 - genetics p38 Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinase 3 - metabolism Anti-Inflammatory Agents - pharmacology p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors Interleukin-1beta - genetics Mitogen-Activated Protein Kinase 9 - metabolism Lipopolysaccharides - pharmacology Kim, Mi Eun oth Lee, Jun Sik oth Enthalten in Applied biochemistry and biotechnology / A New York, NY : Springer, 1994 175(2015), 2, Seite 657-665 (DE-627)182278573 (DE-600)1193054-8 (DE-576)043085105 0273-2289 nnns volume:175 year:2015 number:2 pages:657-665 http://dx.doi.org/10.1007/s12010-014-1301-8 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25342257 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 GBV_ILN_4012 42.00 AVZ AR 175 2015 2 657-665 |
allfieldsGer |
10.1007/s12010-014-1301-8 doi PQ20160617 (DE-627)OLC1967120846 (DE-599)GBVOLC1967120846 (PRQ)c1922-6164b92e85c5a8ceb60008020e85c47f4b9bca9fac3042c1e44ca8f9a7e8a02a0 (KEY)0068751020150000175000200657inhibitoryeffectsofextractfromglanceolataonlpsindu DE-627 ger DE-627 rakwb eng 570 540 660 DNB 42.00 bkl Kim, Dong Hwan verfasserin aut Inhibitory Effects of Extract from G. lanceolata on LPS-Induced Production of Nitric Oxide and IL-1β via Down-regulation of MAPK in Macrophages 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Grateloupia lanceolata is a red alga native to coastal areas of East Asia. In this study, extract from G. lanceolata (EGL) was investigated for suppressive effects on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages. EGL was found to have anti-inflammatory properties with the inhibition of nitric oxide (NO), pro-inflammatory cytokine production, and MAPK signaling in LPS-induced RAW 264.7 macrophages. Moreover, treatment of RAW 264.7 macrophage with EGL inhibited LPS-induced IL-1β production in a dose-dependent manner. These inhibitory effects were found with the blockage of p38 mitogen-activated protein kinases (MAPK), extracellular signal regulated kinases 1 and 2 (ERK1/2), and also c-Jun N-terminal kinases 1 and 2 (JNK1/2). These results indicated that anti-inflammatory actions of EGL in RAW 264.7 macrophages involved in the inhibition of LPS-induced p38MAPK/ERK/JNK signaling pathways. In addition, our findings suggest that EGL holds great promise for use in the treatment of various inflammatory diseases. Nutzungsrecht: © Springer Science+Business Media New York 2015 Biochemistry, general Chemistry Macrophage MAPK signaling Extract from Grateloupia lanceolata Biotechnology Inflammation Rhodophyta - chemistry Interleukin-1beta - antagonists & inhibitors Macrophages - cytology Plant Extracts - pharmacology Mitogen-Activated Protein Kinase 1 - genetics Interleukin-1beta - metabolism Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors Macrophages - drug effects Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors Nitric Oxide - biosynthesis Lipopolysaccharides - antagonists & inhibitors Anti-Inflammatory Agents - chemistry p38 Mitogen-Activated Protein Kinases - metabolism Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 8 - genetics Nitric Oxide - antagonists & inhibitors Mitogen-Activated Protein Kinase 8 - metabolism Plant Extracts - chemistry Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors Macrophages - metabolism Mitogen-Activated Protein Kinase 9 - genetics p38 Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinase 3 - metabolism Anti-Inflammatory Agents - pharmacology p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors Interleukin-1beta - genetics Mitogen-Activated Protein Kinase 9 - metabolism Lipopolysaccharides - pharmacology Kim, Mi Eun oth Lee, Jun Sik oth Enthalten in Applied biochemistry and biotechnology / A New York, NY : Springer, 1994 175(2015), 2, Seite 657-665 (DE-627)182278573 (DE-600)1193054-8 (DE-576)043085105 0273-2289 nnns volume:175 year:2015 number:2 pages:657-665 http://dx.doi.org/10.1007/s12010-014-1301-8 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25342257 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 GBV_ILN_4012 42.00 AVZ AR 175 2015 2 657-665 |
allfieldsSound |
10.1007/s12010-014-1301-8 doi PQ20160617 (DE-627)OLC1967120846 (DE-599)GBVOLC1967120846 (PRQ)c1922-6164b92e85c5a8ceb60008020e85c47f4b9bca9fac3042c1e44ca8f9a7e8a02a0 (KEY)0068751020150000175000200657inhibitoryeffectsofextractfromglanceolataonlpsindu DE-627 ger DE-627 rakwb eng 570 540 660 DNB 42.00 bkl Kim, Dong Hwan verfasserin aut Inhibitory Effects of Extract from G. lanceolata on LPS-Induced Production of Nitric Oxide and IL-1β via Down-regulation of MAPK in Macrophages 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Grateloupia lanceolata is a red alga native to coastal areas of East Asia. In this study, extract from G. lanceolata (EGL) was investigated for suppressive effects on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages. EGL was found to have anti-inflammatory properties with the inhibition of nitric oxide (NO), pro-inflammatory cytokine production, and MAPK signaling in LPS-induced RAW 264.7 macrophages. Moreover, treatment of RAW 264.7 macrophage with EGL inhibited LPS-induced IL-1β production in a dose-dependent manner. These inhibitory effects were found with the blockage of p38 mitogen-activated protein kinases (MAPK), extracellular signal regulated kinases 1 and 2 (ERK1/2), and also c-Jun N-terminal kinases 1 and 2 (JNK1/2). These results indicated that anti-inflammatory actions of EGL in RAW 264.7 macrophages involved in the inhibition of LPS-induced p38MAPK/ERK/JNK signaling pathways. In addition, our findings suggest that EGL holds great promise for use in the treatment of various inflammatory diseases. Nutzungsrecht: © Springer Science+Business Media New York 2015 Biochemistry, general Chemistry Macrophage MAPK signaling Extract from Grateloupia lanceolata Biotechnology Inflammation Rhodophyta - chemistry Interleukin-1beta - antagonists & inhibitors Macrophages - cytology Plant Extracts - pharmacology Mitogen-Activated Protein Kinase 1 - genetics Interleukin-1beta - metabolism Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors Macrophages - drug effects Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors Nitric Oxide - biosynthesis Lipopolysaccharides - antagonists & inhibitors Anti-Inflammatory Agents - chemistry p38 Mitogen-Activated Protein Kinases - metabolism Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 8 - genetics Nitric Oxide - antagonists & inhibitors Mitogen-Activated Protein Kinase 8 - metabolism Plant Extracts - chemistry Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors Macrophages - metabolism Mitogen-Activated Protein Kinase 9 - genetics p38 Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinase 3 - metabolism Anti-Inflammatory Agents - pharmacology p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors Interleukin-1beta - genetics Mitogen-Activated Protein Kinase 9 - metabolism Lipopolysaccharides - pharmacology Kim, Mi Eun oth Lee, Jun Sik oth Enthalten in Applied biochemistry and biotechnology / A New York, NY : Springer, 1994 175(2015), 2, Seite 657-665 (DE-627)182278573 (DE-600)1193054-8 (DE-576)043085105 0273-2289 nnns volume:175 year:2015 number:2 pages:657-665 http://dx.doi.org/10.1007/s12010-014-1301-8 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25342257 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 GBV_ILN_4012 42.00 AVZ AR 175 2015 2 657-665 |
language |
English |
source |
Enthalten in Applied biochemistry and biotechnology / A 175(2015), 2, Seite 657-665 volume:175 year:2015 number:2 pages:657-665 |
sourceStr |
Enthalten in Applied biochemistry and biotechnology / A 175(2015), 2, Seite 657-665 volume:175 year:2015 number:2 pages:657-665 |
format_phy_str_mv |
Article |
institution |
findex.gbv.de |
topic_facet |
Biochemistry, general Chemistry Macrophage MAPK signaling Extract from Grateloupia lanceolata Biotechnology Inflammation Rhodophyta - chemistry Interleukin-1beta - antagonists & inhibitors Macrophages - cytology Plant Extracts - pharmacology Mitogen-Activated Protein Kinase 1 - genetics Interleukin-1beta - metabolism Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors Macrophages - drug effects Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors Nitric Oxide - biosynthesis Lipopolysaccharides - antagonists & inhibitors Anti-Inflammatory Agents - chemistry p38 Mitogen-Activated Protein Kinases - metabolism Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 8 - genetics Nitric Oxide - antagonists & inhibitors Mitogen-Activated Protein Kinase 8 - metabolism Plant Extracts - chemistry Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors Macrophages - metabolism Mitogen-Activated Protein Kinase 9 - genetics p38 Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinase 3 - metabolism Anti-Inflammatory Agents - pharmacology p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors Interleukin-1beta - genetics Mitogen-Activated Protein Kinase 9 - metabolism Lipopolysaccharides - pharmacology |
dewey-raw |
570 |
isfreeaccess_bool |
false |
container_title |
Applied biochemistry and biotechnology / A |
authorswithroles_txt_mv |
Kim, Dong Hwan @@aut@@ Kim, Mi Eun @@oth@@ Lee, Jun Sik @@oth@@ |
publishDateDaySort_date |
2015-01-01T00:00:00Z |
hierarchy_top_id |
182278573 |
dewey-sort |
3570 |
id |
OLC1967120846 |
language_de |
englisch |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a2200265 4500</leader><controlfield tag="001">OLC1967120846</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20220221022429.0</controlfield><controlfield tag="007">tu</controlfield><controlfield tag="008">160206s2015 xx ||||| 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s12010-014-1301-8</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">PQ20160617</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)OLC1967120846</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBVOLC1967120846</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(PRQ)c1922-6164b92e85c5a8ceb60008020e85c47f4b9bca9fac3042c1e44ca8f9a7e8a02a0</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(KEY)0068751020150000175000200657inhibitoryeffectsofextractfromglanceolataonlpsindu</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">570</subfield><subfield code="a">540</subfield><subfield code="a">660</subfield><subfield code="q">DNB</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">42.00</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Kim, Dong Hwan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Inhibitory Effects of Extract from G. lanceolata on LPS-Induced Production of Nitric Oxide and IL-1β via Down-regulation of MAPK in Macrophages</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2015</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">ohne Hilfsmittel zu benutzen</subfield><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Band</subfield><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Grateloupia lanceolata is a red alga native to coastal areas of East Asia. In this study, extract from G. lanceolata (EGL) was investigated for suppressive effects on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages. EGL was found to have anti-inflammatory properties with the inhibition of nitric oxide (NO), pro-inflammatory cytokine production, and MAPK signaling in LPS-induced RAW 264.7 macrophages. Moreover, treatment of RAW 264.7 macrophage with EGL inhibited LPS-induced IL-1β production in a dose-dependent manner. These inhibitory effects were found with the blockage of p38 mitogen-activated protein kinases (MAPK), extracellular signal regulated kinases 1 and 2 (ERK1/2), and also c-Jun N-terminal kinases 1 and 2 (JNK1/2). These results indicated that anti-inflammatory actions of EGL in RAW 264.7 macrophages involved in the inhibition of LPS-induced p38MAPK/ERK/JNK signaling pathways. In addition, our findings suggest that EGL holds great promise for use in the treatment of various inflammatory diseases.</subfield></datafield><datafield tag="540" ind1=" " ind2=" "><subfield code="a">Nutzungsrecht: © Springer Science+Business Media New York 2015</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Biochemistry, general</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Chemistry</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Macrophage</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">MAPK signaling</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Extract from Grateloupia lanceolata</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Biotechnology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Inflammation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Rhodophyta - chemistry</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Interleukin-1beta - antagonists & inhibitors</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Macrophages - cytology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Plant Extracts - pharmacology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mitogen-Activated Protein Kinase 1 - genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Interleukin-1beta - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mitogen-Activated Protein Kinase 1 - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Macrophages - drug effects</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Nitric Oxide - biosynthesis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Lipopolysaccharides - antagonists & inhibitors</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Anti-Inflammatory Agents - chemistry</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">p38 Mitogen-Activated Protein Kinases - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mitogen-Activated Protein Kinase 3 - genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mitogen-Activated Protein Kinase 8 - genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Nitric Oxide - antagonists & inhibitors</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mitogen-Activated Protein Kinase 8 - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Plant Extracts - chemistry</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Macrophages - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mitogen-Activated Protein Kinase 9 - genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">p38 Mitogen-Activated Protein Kinases - genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mitogen-Activated Protein Kinase 3 - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Anti-Inflammatory Agents - pharmacology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Interleukin-1beta - genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mitogen-Activated Protein Kinase 9 - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Lipopolysaccharides - pharmacology</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kim, Mi Eun</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lee, Jun Sik</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Applied biochemistry and biotechnology / A</subfield><subfield code="d">New York, NY : Springer, 1994</subfield><subfield code="g">175(2015), 2, Seite 657-665</subfield><subfield code="w">(DE-627)182278573</subfield><subfield code="w">(DE-600)1193054-8</subfield><subfield code="w">(DE-576)043085105</subfield><subfield code="x">0273-2289</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:175</subfield><subfield code="g">year:2015</subfield><subfield code="g">number:2</subfield><subfield code="g">pages:657-665</subfield></datafield><datafield tag="856" ind1="4" ind2="1"><subfield code="u">http://dx.doi.org/10.1007/s12010-014-1301-8</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">http://www.ncbi.nlm.nih.gov/pubmed/25342257</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_OLC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-TEC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-CHE</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">42.00</subfield><subfield code="q">AVZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">175</subfield><subfield code="j">2015</subfield><subfield code="e">2</subfield><subfield code="h">657-665</subfield></datafield></record></collection>
|
author |
Kim, Dong Hwan |
spellingShingle |
Kim, Dong Hwan ddc 570 bkl 42.00 misc Biochemistry, general misc Chemistry misc Macrophage misc MAPK signaling misc Extract from Grateloupia lanceolata misc Biotechnology misc Inflammation misc Rhodophyta - chemistry misc Interleukin-1beta - antagonists & inhibitors misc Macrophages - cytology misc Plant Extracts - pharmacology misc Mitogen-Activated Protein Kinase 1 - genetics misc Interleukin-1beta - metabolism misc Mitogen-Activated Protein Kinase 1 - metabolism misc Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors misc Macrophages - drug effects misc Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors misc Nitric Oxide - biosynthesis misc Lipopolysaccharides - antagonists & inhibitors misc Anti-Inflammatory Agents - chemistry misc p38 Mitogen-Activated Protein Kinases - metabolism misc Mitogen-Activated Protein Kinase 3 - genetics misc Mitogen-Activated Protein Kinase 8 - genetics misc Nitric Oxide - antagonists & inhibitors misc Mitogen-Activated Protein Kinase 8 - metabolism misc Plant Extracts - chemistry misc Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors misc Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors misc Macrophages - metabolism misc Mitogen-Activated Protein Kinase 9 - genetics misc p38 Mitogen-Activated Protein Kinases - genetics misc Mitogen-Activated Protein Kinase 3 - metabolism misc Anti-Inflammatory Agents - pharmacology misc p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors misc Interleukin-1beta - genetics misc Mitogen-Activated Protein Kinase 9 - metabolism misc Lipopolysaccharides - pharmacology Inhibitory Effects of Extract from G. lanceolata on LPS-Induced Production of Nitric Oxide and IL-1β via Down-regulation of MAPK in Macrophages |
authorStr |
Kim, Dong Hwan |
ppnlink_with_tag_str_mv |
@@773@@(DE-627)182278573 |
format |
Article |
dewey-ones |
570 - Life sciences; biology 540 - Chemistry & allied sciences 660 - Chemical engineering |
delete_txt_mv |
keep |
author_role |
aut |
collection |
OLC |
remote_str |
false |
illustrated |
Not Illustrated |
issn |
0273-2289 |
topic_title |
570 540 660 DNB 42.00 bkl Inhibitory Effects of Extract from G. lanceolata on LPS-Induced Production of Nitric Oxide and IL-1β via Down-regulation of MAPK in Macrophages Biochemistry, general Chemistry Macrophage MAPK signaling Extract from Grateloupia lanceolata Biotechnology Inflammation Rhodophyta - chemistry Interleukin-1beta - antagonists & inhibitors Macrophages - cytology Plant Extracts - pharmacology Mitogen-Activated Protein Kinase 1 - genetics Interleukin-1beta - metabolism Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors Macrophages - drug effects Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors Nitric Oxide - biosynthesis Lipopolysaccharides - antagonists & inhibitors Anti-Inflammatory Agents - chemistry p38 Mitogen-Activated Protein Kinases - metabolism Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 8 - genetics Nitric Oxide - antagonists & inhibitors Mitogen-Activated Protein Kinase 8 - metabolism Plant Extracts - chemistry Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors Macrophages - metabolism Mitogen-Activated Protein Kinase 9 - genetics p38 Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinase 3 - metabolism Anti-Inflammatory Agents - pharmacology p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors Interleukin-1beta - genetics Mitogen-Activated Protein Kinase 9 - metabolism Lipopolysaccharides - pharmacology |
topic |
ddc 570 bkl 42.00 misc Biochemistry, general misc Chemistry misc Macrophage misc MAPK signaling misc Extract from Grateloupia lanceolata misc Biotechnology misc Inflammation misc Rhodophyta - chemistry misc Interleukin-1beta - antagonists & inhibitors misc Macrophages - cytology misc Plant Extracts - pharmacology misc Mitogen-Activated Protein Kinase 1 - genetics misc Interleukin-1beta - metabolism misc Mitogen-Activated Protein Kinase 1 - metabolism misc Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors misc Macrophages - drug effects misc Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors misc Nitric Oxide - biosynthesis misc Lipopolysaccharides - antagonists & inhibitors misc Anti-Inflammatory Agents - chemistry misc p38 Mitogen-Activated Protein Kinases - metabolism misc Mitogen-Activated Protein Kinase 3 - genetics misc Mitogen-Activated Protein Kinase 8 - genetics misc Nitric Oxide - antagonists & inhibitors misc Mitogen-Activated Protein Kinase 8 - metabolism misc Plant Extracts - chemistry misc Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors misc Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors misc Macrophages - metabolism misc Mitogen-Activated Protein Kinase 9 - genetics misc p38 Mitogen-Activated Protein Kinases - genetics misc Mitogen-Activated Protein Kinase 3 - metabolism misc Anti-Inflammatory Agents - pharmacology misc p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors misc Interleukin-1beta - genetics misc Mitogen-Activated Protein Kinase 9 - metabolism misc Lipopolysaccharides - pharmacology |
topic_unstemmed |
ddc 570 bkl 42.00 misc Biochemistry, general misc Chemistry misc Macrophage misc MAPK signaling misc Extract from Grateloupia lanceolata misc Biotechnology misc Inflammation misc Rhodophyta - chemistry misc Interleukin-1beta - antagonists & inhibitors misc Macrophages - cytology misc Plant Extracts - pharmacology misc Mitogen-Activated Protein Kinase 1 - genetics misc Interleukin-1beta - metabolism misc Mitogen-Activated Protein Kinase 1 - metabolism misc Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors misc Macrophages - drug effects misc Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors misc Nitric Oxide - biosynthesis misc Lipopolysaccharides - antagonists & inhibitors misc Anti-Inflammatory Agents - chemistry misc p38 Mitogen-Activated Protein Kinases - metabolism misc Mitogen-Activated Protein Kinase 3 - genetics misc Mitogen-Activated Protein Kinase 8 - genetics misc Nitric Oxide - antagonists & inhibitors misc Mitogen-Activated Protein Kinase 8 - metabolism misc Plant Extracts - chemistry misc Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors misc Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors misc Macrophages - metabolism misc Mitogen-Activated Protein Kinase 9 - genetics misc p38 Mitogen-Activated Protein Kinases - genetics misc Mitogen-Activated Protein Kinase 3 - metabolism misc Anti-Inflammatory Agents - pharmacology misc p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors misc Interleukin-1beta - genetics misc Mitogen-Activated Protein Kinase 9 - metabolism misc Lipopolysaccharides - pharmacology |
topic_browse |
ddc 570 bkl 42.00 misc Biochemistry, general misc Chemistry misc Macrophage misc MAPK signaling misc Extract from Grateloupia lanceolata misc Biotechnology misc Inflammation misc Rhodophyta - chemistry misc Interleukin-1beta - antagonists & inhibitors misc Macrophages - cytology misc Plant Extracts - pharmacology misc Mitogen-Activated Protein Kinase 1 - genetics misc Interleukin-1beta - metabolism misc Mitogen-Activated Protein Kinase 1 - metabolism misc Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors misc Macrophages - drug effects misc Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors misc Nitric Oxide - biosynthesis misc Lipopolysaccharides - antagonists & inhibitors misc Anti-Inflammatory Agents - chemistry misc p38 Mitogen-Activated Protein Kinases - metabolism misc Mitogen-Activated Protein Kinase 3 - genetics misc Mitogen-Activated Protein Kinase 8 - genetics misc Nitric Oxide - antagonists & inhibitors misc Mitogen-Activated Protein Kinase 8 - metabolism misc Plant Extracts - chemistry misc Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors misc Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors misc Macrophages - metabolism misc Mitogen-Activated Protein Kinase 9 - genetics misc p38 Mitogen-Activated Protein Kinases - genetics misc Mitogen-Activated Protein Kinase 3 - metabolism misc Anti-Inflammatory Agents - pharmacology misc p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors misc Interleukin-1beta - genetics misc Mitogen-Activated Protein Kinase 9 - metabolism misc Lipopolysaccharides - pharmacology |
format_facet |
Aufsätze Gedruckte Aufsätze |
format_main_str_mv |
Text Zeitschrift/Artikel |
carriertype_str_mv |
nc |
author2_variant |
m e k me mek j s l js jsl |
hierarchy_parent_title |
Applied biochemistry and biotechnology / A |
hierarchy_parent_id |
182278573 |
dewey-tens |
570 - Life sciences; biology 540 - Chemistry 660 - Chemical engineering |
hierarchy_top_title |
Applied biochemistry and biotechnology / A |
isfreeaccess_txt |
false |
familylinks_str_mv |
(DE-627)182278573 (DE-600)1193054-8 (DE-576)043085105 |
title |
Inhibitory Effects of Extract from G. lanceolata on LPS-Induced Production of Nitric Oxide and IL-1β via Down-regulation of MAPK in Macrophages |
ctrlnum |
(DE-627)OLC1967120846 (DE-599)GBVOLC1967120846 (PRQ)c1922-6164b92e85c5a8ceb60008020e85c47f4b9bca9fac3042c1e44ca8f9a7e8a02a0 (KEY)0068751020150000175000200657inhibitoryeffectsofextractfromglanceolataonlpsindu |
title_full |
Inhibitory Effects of Extract from G. lanceolata on LPS-Induced Production of Nitric Oxide and IL-1β via Down-regulation of MAPK in Macrophages |
author_sort |
Kim, Dong Hwan |
journal |
Applied biochemistry and biotechnology / A |
journalStr |
Applied biochemistry and biotechnology / A |
lang_code |
eng |
isOA_bool |
false |
dewey-hundreds |
500 - Science 600 - Technology |
recordtype |
marc |
publishDateSort |
2015 |
contenttype_str_mv |
txt |
container_start_page |
657 |
author_browse |
Kim, Dong Hwan |
container_volume |
175 |
class |
570 540 660 DNB 42.00 bkl |
format_se |
Aufsätze |
author-letter |
Kim, Dong Hwan |
doi_str_mv |
10.1007/s12010-014-1301-8 |
dewey-full |
570 540 660 |
title_sort |
inhibitory effects of extract from g. lanceolata on lps-induced production of nitric oxide and il-1β via down-regulation of mapk in macrophages |
title_auth |
Inhibitory Effects of Extract from G. lanceolata on LPS-Induced Production of Nitric Oxide and IL-1β via Down-regulation of MAPK in Macrophages |
abstract |
Grateloupia lanceolata is a red alga native to coastal areas of East Asia. In this study, extract from G. lanceolata (EGL) was investigated for suppressive effects on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages. EGL was found to have anti-inflammatory properties with the inhibition of nitric oxide (NO), pro-inflammatory cytokine production, and MAPK signaling in LPS-induced RAW 264.7 macrophages. Moreover, treatment of RAW 264.7 macrophage with EGL inhibited LPS-induced IL-1β production in a dose-dependent manner. These inhibitory effects were found with the blockage of p38 mitogen-activated protein kinases (MAPK), extracellular signal regulated kinases 1 and 2 (ERK1/2), and also c-Jun N-terminal kinases 1 and 2 (JNK1/2). These results indicated that anti-inflammatory actions of EGL in RAW 264.7 macrophages involved in the inhibition of LPS-induced p38MAPK/ERK/JNK signaling pathways. In addition, our findings suggest that EGL holds great promise for use in the treatment of various inflammatory diseases. |
abstractGer |
Grateloupia lanceolata is a red alga native to coastal areas of East Asia. In this study, extract from G. lanceolata (EGL) was investigated for suppressive effects on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages. EGL was found to have anti-inflammatory properties with the inhibition of nitric oxide (NO), pro-inflammatory cytokine production, and MAPK signaling in LPS-induced RAW 264.7 macrophages. Moreover, treatment of RAW 264.7 macrophage with EGL inhibited LPS-induced IL-1β production in a dose-dependent manner. These inhibitory effects were found with the blockage of p38 mitogen-activated protein kinases (MAPK), extracellular signal regulated kinases 1 and 2 (ERK1/2), and also c-Jun N-terminal kinases 1 and 2 (JNK1/2). These results indicated that anti-inflammatory actions of EGL in RAW 264.7 macrophages involved in the inhibition of LPS-induced p38MAPK/ERK/JNK signaling pathways. In addition, our findings suggest that EGL holds great promise for use in the treatment of various inflammatory diseases. |
abstract_unstemmed |
Grateloupia lanceolata is a red alga native to coastal areas of East Asia. In this study, extract from G. lanceolata (EGL) was investigated for suppressive effects on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages. EGL was found to have anti-inflammatory properties with the inhibition of nitric oxide (NO), pro-inflammatory cytokine production, and MAPK signaling in LPS-induced RAW 264.7 macrophages. Moreover, treatment of RAW 264.7 macrophage with EGL inhibited LPS-induced IL-1β production in a dose-dependent manner. These inhibitory effects were found with the blockage of p38 mitogen-activated protein kinases (MAPK), extracellular signal regulated kinases 1 and 2 (ERK1/2), and also c-Jun N-terminal kinases 1 and 2 (JNK1/2). These results indicated that anti-inflammatory actions of EGL in RAW 264.7 macrophages involved in the inhibition of LPS-induced p38MAPK/ERK/JNK signaling pathways. In addition, our findings suggest that EGL holds great promise for use in the treatment of various inflammatory diseases. |
collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 GBV_ILN_4012 |
container_issue |
2 |
title_short |
Inhibitory Effects of Extract from G. lanceolata on LPS-Induced Production of Nitric Oxide and IL-1β via Down-regulation of MAPK in Macrophages |
url |
http://dx.doi.org/10.1007/s12010-014-1301-8 http://www.ncbi.nlm.nih.gov/pubmed/25342257 |
remote_bool |
false |
author2 |
Kim, Mi Eun Lee, Jun Sik |
author2Str |
Kim, Mi Eun Lee, Jun Sik |
ppnlink |
182278573 |
mediatype_str_mv |
n |
isOA_txt |
false |
hochschulschrift_bool |
false |
author2_role |
oth oth |
doi_str |
10.1007/s12010-014-1301-8 |
up_date |
2024-07-03T23:59:48.414Z |
_version_ |
1803604394983292928 |
fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a2200265 4500</leader><controlfield tag="001">OLC1967120846</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20220221022429.0</controlfield><controlfield tag="007">tu</controlfield><controlfield tag="008">160206s2015 xx ||||| 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s12010-014-1301-8</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">PQ20160617</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)OLC1967120846</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBVOLC1967120846</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(PRQ)c1922-6164b92e85c5a8ceb60008020e85c47f4b9bca9fac3042c1e44ca8f9a7e8a02a0</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(KEY)0068751020150000175000200657inhibitoryeffectsofextractfromglanceolataonlpsindu</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">570</subfield><subfield code="a">540</subfield><subfield code="a">660</subfield><subfield code="q">DNB</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">42.00</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Kim, Dong Hwan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Inhibitory Effects of Extract from G. lanceolata on LPS-Induced Production of Nitric Oxide and IL-1β via Down-regulation of MAPK in Macrophages</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2015</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">ohne Hilfsmittel zu benutzen</subfield><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Band</subfield><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Grateloupia lanceolata is a red alga native to coastal areas of East Asia. In this study, extract from G. lanceolata (EGL) was investigated for suppressive effects on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages. EGL was found to have anti-inflammatory properties with the inhibition of nitric oxide (NO), pro-inflammatory cytokine production, and MAPK signaling in LPS-induced RAW 264.7 macrophages. Moreover, treatment of RAW 264.7 macrophage with EGL inhibited LPS-induced IL-1β production in a dose-dependent manner. These inhibitory effects were found with the blockage of p38 mitogen-activated protein kinases (MAPK), extracellular signal regulated kinases 1 and 2 (ERK1/2), and also c-Jun N-terminal kinases 1 and 2 (JNK1/2). These results indicated that anti-inflammatory actions of EGL in RAW 264.7 macrophages involved in the inhibition of LPS-induced p38MAPK/ERK/JNK signaling pathways. In addition, our findings suggest that EGL holds great promise for use in the treatment of various inflammatory diseases.</subfield></datafield><datafield tag="540" ind1=" " ind2=" "><subfield code="a">Nutzungsrecht: © Springer Science+Business Media New York 2015</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Biochemistry, general</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Chemistry</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Macrophage</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">MAPK signaling</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Extract from Grateloupia lanceolata</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Biotechnology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Inflammation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Rhodophyta - chemistry</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Interleukin-1beta - antagonists & inhibitors</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Macrophages - cytology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Plant Extracts - pharmacology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mitogen-Activated Protein Kinase 1 - genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Interleukin-1beta - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mitogen-Activated Protein Kinase 1 - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Macrophages - drug effects</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Nitric Oxide - biosynthesis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Lipopolysaccharides - antagonists & inhibitors</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Anti-Inflammatory Agents - chemistry</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">p38 Mitogen-Activated Protein Kinases - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mitogen-Activated Protein Kinase 3 - genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mitogen-Activated Protein Kinase 8 - genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Nitric Oxide - antagonists & inhibitors</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mitogen-Activated Protein Kinase 8 - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Plant Extracts - chemistry</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Macrophages - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mitogen-Activated Protein Kinase 9 - genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">p38 Mitogen-Activated Protein Kinases - genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mitogen-Activated Protein Kinase 3 - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Anti-Inflammatory Agents - pharmacology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Interleukin-1beta - genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mitogen-Activated Protein Kinase 9 - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Lipopolysaccharides - pharmacology</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kim, Mi Eun</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lee, Jun Sik</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Applied biochemistry and biotechnology / A</subfield><subfield code="d">New York, NY : Springer, 1994</subfield><subfield code="g">175(2015), 2, Seite 657-665</subfield><subfield code="w">(DE-627)182278573</subfield><subfield code="w">(DE-600)1193054-8</subfield><subfield code="w">(DE-576)043085105</subfield><subfield code="x">0273-2289</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:175</subfield><subfield code="g">year:2015</subfield><subfield code="g">number:2</subfield><subfield code="g">pages:657-665</subfield></datafield><datafield tag="856" ind1="4" ind2="1"><subfield code="u">http://dx.doi.org/10.1007/s12010-014-1301-8</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">http://www.ncbi.nlm.nih.gov/pubmed/25342257</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_OLC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-TEC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-CHE</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">42.00</subfield><subfield code="q">AVZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">175</subfield><subfield code="j">2015</subfield><subfield code="e">2</subfield><subfield code="h">657-665</subfield></datafield></record></collection>
|
score |
7.4008036 |