Inhibitory Effects of Extract from G. lanceolata on LPS-Induced Production of Nitric Oxide and IL-1β via Down-regulation of MAPK in Macrophages
Grateloupia lanceolata is a red alga native to coastal areas of East Asia. In this study, extract from G. lanceolata (EGL) was investigated for suppressive effects on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages. EGL was found to have anti-inflammatory properties...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Kim, Dong Hwan [verfasserIn] |
|---|
| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Rechteinformationen: |
Nutzungsrecht: © Springer Science+Business Media New York 2015 |
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| Übergeordnetes Werk: |
Enthalten in: Applied biochemistry and biotechnology / A - New York, NY : Springer, 1994, 175(2015), 2, Seite 657-665 |
|---|---|
| Übergeordnetes Werk: |
volume:175 ; year:2015 ; number:2 ; pages:657-665 |
| Links: |
|---|
| DOI / URN: |
10.1007/s12010-014-1301-8 |
|---|
| Katalog-ID: |
OLC1967120846 |
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| 245 | 1 | 0 | |a Inhibitory Effects of Extract from G. lanceolata on LPS-Induced Production of Nitric Oxide and IL-1β via Down-regulation of MAPK in Macrophages |
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| 520 | |a Grateloupia lanceolata is a red alga native to coastal areas of East Asia. In this study, extract from G. lanceolata (EGL) was investigated for suppressive effects on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages. EGL was found to have anti-inflammatory properties with the inhibition of nitric oxide (NO), pro-inflammatory cytokine production, and MAPK signaling in LPS-induced RAW 264.7 macrophages. Moreover, treatment of RAW 264.7 macrophage with EGL inhibited LPS-induced IL-1β production in a dose-dependent manner. These inhibitory effects were found with the blockage of p38 mitogen-activated protein kinases (MAPK), extracellular signal regulated kinases 1 and 2 (ERK1/2), and also c-Jun N-terminal kinases 1 and 2 (JNK1/2). These results indicated that anti-inflammatory actions of EGL in RAW 264.7 macrophages involved in the inhibition of LPS-induced p38MAPK/ERK/JNK signaling pathways. In addition, our findings suggest that EGL holds great promise for use in the treatment of various inflammatory diseases. | ||
| 540 | |a Nutzungsrecht: © Springer Science+Business Media New York 2015 | ||
| 650 | 4 | |a Biochemistry, general | |
| 650 | 4 | |a Chemistry | |
| 650 | 4 | |a Macrophage | |
| 650 | 4 | |a MAPK signaling | |
| 650 | 4 | |a Extract from Grateloupia lanceolata | |
| 650 | 4 | |a Biotechnology | |
| 650 | 4 | |a Inflammation | |
| 650 | 4 | |a Rhodophyta - chemistry | |
| 650 | 4 | |a Interleukin-1beta - antagonists & inhibitors | |
| 650 | 4 | |a Macrophages - cytology | |
| 650 | 4 | |a Plant Extracts - pharmacology | |
| 650 | 4 | |a Mitogen-Activated Protein Kinase 1 - genetics | |
| 650 | 4 | |a Interleukin-1beta - metabolism | |
| 650 | 4 | |a Mitogen-Activated Protein Kinase 1 - metabolism | |
| 650 | 4 | |a Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | |
| 650 | 4 | |a Macrophages - drug effects | |
| 650 | 4 | |a Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors | |
| 650 | 4 | |a Nitric Oxide - biosynthesis | |
| 650 | 4 | |a Lipopolysaccharides - antagonists & inhibitors | |
| 650 | 4 | |a Anti-Inflammatory Agents - chemistry | |
| 650 | 4 | |a p38 Mitogen-Activated Protein Kinases - metabolism | |
| 650 | 4 | |a Mitogen-Activated Protein Kinase 3 - genetics | |
| 650 | 4 | |a Mitogen-Activated Protein Kinase 8 - genetics | |
| 650 | 4 | |a Nitric Oxide - antagonists & inhibitors | |
| 650 | 4 | |a Mitogen-Activated Protein Kinase 8 - metabolism | |
| 650 | 4 | |a Plant Extracts - chemistry | |
| 650 | 4 | |a Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors | |
| 650 | 4 | |a Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | |
| 650 | 4 | |a Macrophages - metabolism | |
| 650 | 4 | |a Mitogen-Activated Protein Kinase 9 - genetics | |
| 650 | 4 | |a p38 Mitogen-Activated Protein Kinases - genetics | |
| 650 | 4 | |a Mitogen-Activated Protein Kinase 3 - metabolism | |
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| 650 | 4 | |a p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | |
| 650 | 4 | |a Interleukin-1beta - genetics | |
| 650 | 4 | |a Mitogen-Activated Protein Kinase 9 - metabolism | |
| 650 | 4 | |a Lipopolysaccharides - pharmacology | |
| 700 | 1 | |a Kim, Mi Eun |4 oth | |
| 700 | 1 | |a Lee, Jun Sik |4 oth | |
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10.1007/s12010-014-1301-8 doi PQ20160617 (DE-627)OLC1967120846 (DE-599)GBVOLC1967120846 (PRQ)c1922-6164b92e85c5a8ceb60008020e85c47f4b9bca9fac3042c1e44ca8f9a7e8a02a0 (KEY)0068751020150000175000200657inhibitoryeffectsofextractfromglanceolataonlpsindu DE-627 ger DE-627 rakwb eng 570 540 660 DNB 42.00 bkl Kim, Dong Hwan verfasserin aut Inhibitory Effects of Extract from G. lanceolata on LPS-Induced Production of Nitric Oxide and IL-1β via Down-regulation of MAPK in Macrophages 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Grateloupia lanceolata is a red alga native to coastal areas of East Asia. In this study, extract from G. lanceolata (EGL) was investigated for suppressive effects on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages. EGL was found to have anti-inflammatory properties with the inhibition of nitric oxide (NO), pro-inflammatory cytokine production, and MAPK signaling in LPS-induced RAW 264.7 macrophages. Moreover, treatment of RAW 264.7 macrophage with EGL inhibited LPS-induced IL-1β production in a dose-dependent manner. These inhibitory effects were found with the blockage of p38 mitogen-activated protein kinases (MAPK), extracellular signal regulated kinases 1 and 2 (ERK1/2), and also c-Jun N-terminal kinases 1 and 2 (JNK1/2). These results indicated that anti-inflammatory actions of EGL in RAW 264.7 macrophages involved in the inhibition of LPS-induced p38MAPK/ERK/JNK signaling pathways. In addition, our findings suggest that EGL holds great promise for use in the treatment of various inflammatory diseases. Nutzungsrecht: © Springer Science+Business Media New York 2015 Biochemistry, general Chemistry Macrophage MAPK signaling Extract from Grateloupia lanceolata Biotechnology Inflammation Rhodophyta - chemistry Interleukin-1beta - antagonists & inhibitors Macrophages - cytology Plant Extracts - pharmacology Mitogen-Activated Protein Kinase 1 - genetics Interleukin-1beta - metabolism Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors Macrophages - drug effects Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors Nitric Oxide - biosynthesis Lipopolysaccharides - antagonists & inhibitors Anti-Inflammatory Agents - chemistry p38 Mitogen-Activated Protein Kinases - metabolism Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 8 - genetics Nitric Oxide - antagonists & inhibitors Mitogen-Activated Protein Kinase 8 - metabolism Plant Extracts - chemistry Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors Macrophages - metabolism Mitogen-Activated Protein Kinase 9 - genetics p38 Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinase 3 - metabolism Anti-Inflammatory Agents - pharmacology p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors Interleukin-1beta - genetics Mitogen-Activated Protein Kinase 9 - metabolism Lipopolysaccharides - pharmacology Kim, Mi Eun oth Lee, Jun Sik oth Enthalten in Applied biochemistry and biotechnology / A New York, NY : Springer, 1994 175(2015), 2, Seite 657-665 (DE-627)182278573 (DE-600)1193054-8 (DE-576)043085105 0273-2289 nnns volume:175 year:2015 number:2 pages:657-665 http://dx.doi.org/10.1007/s12010-014-1301-8 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25342257 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 GBV_ILN_4012 42.00 AVZ AR 175 2015 2 657-665 |
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10.1007/s12010-014-1301-8 doi PQ20160617 (DE-627)OLC1967120846 (DE-599)GBVOLC1967120846 (PRQ)c1922-6164b92e85c5a8ceb60008020e85c47f4b9bca9fac3042c1e44ca8f9a7e8a02a0 (KEY)0068751020150000175000200657inhibitoryeffectsofextractfromglanceolataonlpsindu DE-627 ger DE-627 rakwb eng 570 540 660 DNB 42.00 bkl Kim, Dong Hwan verfasserin aut Inhibitory Effects of Extract from G. lanceolata on LPS-Induced Production of Nitric Oxide and IL-1β via Down-regulation of MAPK in Macrophages 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Grateloupia lanceolata is a red alga native to coastal areas of East Asia. In this study, extract from G. lanceolata (EGL) was investigated for suppressive effects on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages. EGL was found to have anti-inflammatory properties with the inhibition of nitric oxide (NO), pro-inflammatory cytokine production, and MAPK signaling in LPS-induced RAW 264.7 macrophages. Moreover, treatment of RAW 264.7 macrophage with EGL inhibited LPS-induced IL-1β production in a dose-dependent manner. These inhibitory effects were found with the blockage of p38 mitogen-activated protein kinases (MAPK), extracellular signal regulated kinases 1 and 2 (ERK1/2), and also c-Jun N-terminal kinases 1 and 2 (JNK1/2). These results indicated that anti-inflammatory actions of EGL in RAW 264.7 macrophages involved in the inhibition of LPS-induced p38MAPK/ERK/JNK signaling pathways. In addition, our findings suggest that EGL holds great promise for use in the treatment of various inflammatory diseases. Nutzungsrecht: © Springer Science+Business Media New York 2015 Biochemistry, general Chemistry Macrophage MAPK signaling Extract from Grateloupia lanceolata Biotechnology Inflammation Rhodophyta - chemistry Interleukin-1beta - antagonists & inhibitors Macrophages - cytology Plant Extracts - pharmacology Mitogen-Activated Protein Kinase 1 - genetics Interleukin-1beta - metabolism Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors Macrophages - drug effects Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors Nitric Oxide - biosynthesis Lipopolysaccharides - antagonists & inhibitors Anti-Inflammatory Agents - chemistry p38 Mitogen-Activated Protein Kinases - metabolism Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 8 - genetics Nitric Oxide - antagonists & inhibitors Mitogen-Activated Protein Kinase 8 - metabolism Plant Extracts - chemistry Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors Macrophages - metabolism Mitogen-Activated Protein Kinase 9 - genetics p38 Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinase 3 - metabolism Anti-Inflammatory Agents - pharmacology p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors Interleukin-1beta - genetics Mitogen-Activated Protein Kinase 9 - metabolism Lipopolysaccharides - pharmacology Kim, Mi Eun oth Lee, Jun Sik oth Enthalten in Applied biochemistry and biotechnology / A New York, NY : Springer, 1994 175(2015), 2, Seite 657-665 (DE-627)182278573 (DE-600)1193054-8 (DE-576)043085105 0273-2289 nnns volume:175 year:2015 number:2 pages:657-665 http://dx.doi.org/10.1007/s12010-014-1301-8 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25342257 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 GBV_ILN_4012 42.00 AVZ AR 175 2015 2 657-665 |
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10.1007/s12010-014-1301-8 doi PQ20160617 (DE-627)OLC1967120846 (DE-599)GBVOLC1967120846 (PRQ)c1922-6164b92e85c5a8ceb60008020e85c47f4b9bca9fac3042c1e44ca8f9a7e8a02a0 (KEY)0068751020150000175000200657inhibitoryeffectsofextractfromglanceolataonlpsindu DE-627 ger DE-627 rakwb eng 570 540 660 DNB 42.00 bkl Kim, Dong Hwan verfasserin aut Inhibitory Effects of Extract from G. lanceolata on LPS-Induced Production of Nitric Oxide and IL-1β via Down-regulation of MAPK in Macrophages 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Grateloupia lanceolata is a red alga native to coastal areas of East Asia. In this study, extract from G. lanceolata (EGL) was investigated for suppressive effects on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages. EGL was found to have anti-inflammatory properties with the inhibition of nitric oxide (NO), pro-inflammatory cytokine production, and MAPK signaling in LPS-induced RAW 264.7 macrophages. Moreover, treatment of RAW 264.7 macrophage with EGL inhibited LPS-induced IL-1β production in a dose-dependent manner. These inhibitory effects were found with the blockage of p38 mitogen-activated protein kinases (MAPK), extracellular signal regulated kinases 1 and 2 (ERK1/2), and also c-Jun N-terminal kinases 1 and 2 (JNK1/2). These results indicated that anti-inflammatory actions of EGL in RAW 264.7 macrophages involved in the inhibition of LPS-induced p38MAPK/ERK/JNK signaling pathways. In addition, our findings suggest that EGL holds great promise for use in the treatment of various inflammatory diseases. Nutzungsrecht: © Springer Science+Business Media New York 2015 Biochemistry, general Chemistry Macrophage MAPK signaling Extract from Grateloupia lanceolata Biotechnology Inflammation Rhodophyta - chemistry Interleukin-1beta - antagonists & inhibitors Macrophages - cytology Plant Extracts - pharmacology Mitogen-Activated Protein Kinase 1 - genetics Interleukin-1beta - metabolism Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors Macrophages - drug effects Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors Nitric Oxide - biosynthesis Lipopolysaccharides - antagonists & inhibitors Anti-Inflammatory Agents - chemistry p38 Mitogen-Activated Protein Kinases - metabolism Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 8 - genetics Nitric Oxide - antagonists & inhibitors Mitogen-Activated Protein Kinase 8 - metabolism Plant Extracts - chemistry Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors Macrophages - metabolism Mitogen-Activated Protein Kinase 9 - genetics p38 Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinase 3 - metabolism Anti-Inflammatory Agents - pharmacology p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors Interleukin-1beta - genetics Mitogen-Activated Protein Kinase 9 - metabolism Lipopolysaccharides - pharmacology Kim, Mi Eun oth Lee, Jun Sik oth Enthalten in Applied biochemistry and biotechnology / A New York, NY : Springer, 1994 175(2015), 2, Seite 657-665 (DE-627)182278573 (DE-600)1193054-8 (DE-576)043085105 0273-2289 nnns volume:175 year:2015 number:2 pages:657-665 http://dx.doi.org/10.1007/s12010-014-1301-8 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25342257 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 GBV_ILN_4012 42.00 AVZ AR 175 2015 2 657-665 |
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10.1007/s12010-014-1301-8 doi PQ20160617 (DE-627)OLC1967120846 (DE-599)GBVOLC1967120846 (PRQ)c1922-6164b92e85c5a8ceb60008020e85c47f4b9bca9fac3042c1e44ca8f9a7e8a02a0 (KEY)0068751020150000175000200657inhibitoryeffectsofextractfromglanceolataonlpsindu DE-627 ger DE-627 rakwb eng 570 540 660 DNB 42.00 bkl Kim, Dong Hwan verfasserin aut Inhibitory Effects of Extract from G. lanceolata on LPS-Induced Production of Nitric Oxide and IL-1β via Down-regulation of MAPK in Macrophages 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Grateloupia lanceolata is a red alga native to coastal areas of East Asia. In this study, extract from G. lanceolata (EGL) was investigated for suppressive effects on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages. EGL was found to have anti-inflammatory properties with the inhibition of nitric oxide (NO), pro-inflammatory cytokine production, and MAPK signaling in LPS-induced RAW 264.7 macrophages. Moreover, treatment of RAW 264.7 macrophage with EGL inhibited LPS-induced IL-1β production in a dose-dependent manner. These inhibitory effects were found with the blockage of p38 mitogen-activated protein kinases (MAPK), extracellular signal regulated kinases 1 and 2 (ERK1/2), and also c-Jun N-terminal kinases 1 and 2 (JNK1/2). These results indicated that anti-inflammatory actions of EGL in RAW 264.7 macrophages involved in the inhibition of LPS-induced p38MAPK/ERK/JNK signaling pathways. In addition, our findings suggest that EGL holds great promise for use in the treatment of various inflammatory diseases. Nutzungsrecht: © Springer Science+Business Media New York 2015 Biochemistry, general Chemistry Macrophage MAPK signaling Extract from Grateloupia lanceolata Biotechnology Inflammation Rhodophyta - chemistry Interleukin-1beta - antagonists & inhibitors Macrophages - cytology Plant Extracts - pharmacology Mitogen-Activated Protein Kinase 1 - genetics Interleukin-1beta - metabolism Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors Macrophages - drug effects Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors Nitric Oxide - biosynthesis Lipopolysaccharides - antagonists & inhibitors Anti-Inflammatory Agents - chemistry p38 Mitogen-Activated Protein Kinases - metabolism Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 8 - genetics Nitric Oxide - antagonists & inhibitors Mitogen-Activated Protein Kinase 8 - metabolism Plant Extracts - chemistry Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors Macrophages - metabolism Mitogen-Activated Protein Kinase 9 - genetics p38 Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinase 3 - metabolism Anti-Inflammatory Agents - pharmacology p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors Interleukin-1beta - genetics Mitogen-Activated Protein Kinase 9 - metabolism Lipopolysaccharides - pharmacology Kim, Mi Eun oth Lee, Jun Sik oth Enthalten in Applied biochemistry and biotechnology / A New York, NY : Springer, 1994 175(2015), 2, Seite 657-665 (DE-627)182278573 (DE-600)1193054-8 (DE-576)043085105 0273-2289 nnns volume:175 year:2015 number:2 pages:657-665 http://dx.doi.org/10.1007/s12010-014-1301-8 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25342257 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 GBV_ILN_4012 42.00 AVZ AR 175 2015 2 657-665 |
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10.1007/s12010-014-1301-8 doi PQ20160617 (DE-627)OLC1967120846 (DE-599)GBVOLC1967120846 (PRQ)c1922-6164b92e85c5a8ceb60008020e85c47f4b9bca9fac3042c1e44ca8f9a7e8a02a0 (KEY)0068751020150000175000200657inhibitoryeffectsofextractfromglanceolataonlpsindu DE-627 ger DE-627 rakwb eng 570 540 660 DNB 42.00 bkl Kim, Dong Hwan verfasserin aut Inhibitory Effects of Extract from G. lanceolata on LPS-Induced Production of Nitric Oxide and IL-1β via Down-regulation of MAPK in Macrophages 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Grateloupia lanceolata is a red alga native to coastal areas of East Asia. In this study, extract from G. lanceolata (EGL) was investigated for suppressive effects on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages. EGL was found to have anti-inflammatory properties with the inhibition of nitric oxide (NO), pro-inflammatory cytokine production, and MAPK signaling in LPS-induced RAW 264.7 macrophages. Moreover, treatment of RAW 264.7 macrophage with EGL inhibited LPS-induced IL-1β production in a dose-dependent manner. These inhibitory effects were found with the blockage of p38 mitogen-activated protein kinases (MAPK), extracellular signal regulated kinases 1 and 2 (ERK1/2), and also c-Jun N-terminal kinases 1 and 2 (JNK1/2). These results indicated that anti-inflammatory actions of EGL in RAW 264.7 macrophages involved in the inhibition of LPS-induced p38MAPK/ERK/JNK signaling pathways. In addition, our findings suggest that EGL holds great promise for use in the treatment of various inflammatory diseases. Nutzungsrecht: © Springer Science+Business Media New York 2015 Biochemistry, general Chemistry Macrophage MAPK signaling Extract from Grateloupia lanceolata Biotechnology Inflammation Rhodophyta - chemistry Interleukin-1beta - antagonists & inhibitors Macrophages - cytology Plant Extracts - pharmacology Mitogen-Activated Protein Kinase 1 - genetics Interleukin-1beta - metabolism Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors Macrophages - drug effects Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors Nitric Oxide - biosynthesis Lipopolysaccharides - antagonists & inhibitors Anti-Inflammatory Agents - chemistry p38 Mitogen-Activated Protein Kinases - metabolism Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 8 - genetics Nitric Oxide - antagonists & inhibitors Mitogen-Activated Protein Kinase 8 - metabolism Plant Extracts - chemistry Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors Macrophages - metabolism Mitogen-Activated Protein Kinase 9 - genetics p38 Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinase 3 - metabolism Anti-Inflammatory Agents - pharmacology p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors Interleukin-1beta - genetics Mitogen-Activated Protein Kinase 9 - metabolism Lipopolysaccharides - pharmacology Kim, Mi Eun oth Lee, Jun Sik oth Enthalten in Applied biochemistry and biotechnology / A New York, NY : Springer, 1994 175(2015), 2, Seite 657-665 (DE-627)182278573 (DE-600)1193054-8 (DE-576)043085105 0273-2289 nnns volume:175 year:2015 number:2 pages:657-665 http://dx.doi.org/10.1007/s12010-014-1301-8 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25342257 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 GBV_ILN_4012 42.00 AVZ AR 175 2015 2 657-665 |
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Kim, Dong Hwan ddc 570 bkl 42.00 misc Biochemistry, general misc Chemistry misc Macrophage misc MAPK signaling misc Extract from Grateloupia lanceolata misc Biotechnology misc Inflammation misc Rhodophyta - chemistry misc Interleukin-1beta - antagonists & inhibitors misc Macrophages - cytology misc Plant Extracts - pharmacology misc Mitogen-Activated Protein Kinase 1 - genetics misc Interleukin-1beta - metabolism misc Mitogen-Activated Protein Kinase 1 - metabolism misc Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors misc Macrophages - drug effects misc Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors misc Nitric Oxide - biosynthesis misc Lipopolysaccharides - antagonists & inhibitors misc Anti-Inflammatory Agents - chemistry misc p38 Mitogen-Activated Protein Kinases - metabolism misc Mitogen-Activated Protein Kinase 3 - genetics misc Mitogen-Activated Protein Kinase 8 - genetics misc Nitric Oxide - antagonists & inhibitors misc Mitogen-Activated Protein Kinase 8 - metabolism misc Plant Extracts - chemistry misc Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors misc Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors misc Macrophages - metabolism misc Mitogen-Activated Protein Kinase 9 - genetics misc p38 Mitogen-Activated Protein Kinases - genetics misc Mitogen-Activated Protein Kinase 3 - metabolism misc Anti-Inflammatory Agents - pharmacology misc p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors misc Interleukin-1beta - genetics misc Mitogen-Activated Protein Kinase 9 - metabolism misc Lipopolysaccharides - pharmacology Inhibitory Effects of Extract from G. lanceolata on LPS-Induced Production of Nitric Oxide and IL-1β via Down-regulation of MAPK in Macrophages |
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570 540 660 DNB 42.00 bkl Inhibitory Effects of Extract from G. lanceolata on LPS-Induced Production of Nitric Oxide and IL-1β via Down-regulation of MAPK in Macrophages Biochemistry, general Chemistry Macrophage MAPK signaling Extract from Grateloupia lanceolata Biotechnology Inflammation Rhodophyta - chemistry Interleukin-1beta - antagonists & inhibitors Macrophages - cytology Plant Extracts - pharmacology Mitogen-Activated Protein Kinase 1 - genetics Interleukin-1beta - metabolism Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors Macrophages - drug effects Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors Nitric Oxide - biosynthesis Lipopolysaccharides - antagonists & inhibitors Anti-Inflammatory Agents - chemistry p38 Mitogen-Activated Protein Kinases - metabolism Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 8 - genetics Nitric Oxide - antagonists & inhibitors Mitogen-Activated Protein Kinase 8 - metabolism Plant Extracts - chemistry Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors Macrophages - metabolism Mitogen-Activated Protein Kinase 9 - genetics p38 Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinase 3 - metabolism Anti-Inflammatory Agents - pharmacology p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors Interleukin-1beta - genetics Mitogen-Activated Protein Kinase 9 - metabolism Lipopolysaccharides - pharmacology |
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inhibitory effects of extract from g. lanceolata on lps-induced production of nitric oxide and il-1β via down-regulation of mapk in macrophages |
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Inhibitory Effects of Extract from G. lanceolata on LPS-Induced Production of Nitric Oxide and IL-1β via Down-regulation of MAPK in Macrophages |
| abstract |
Grateloupia lanceolata is a red alga native to coastal areas of East Asia. In this study, extract from G. lanceolata (EGL) was investigated for suppressive effects on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages. EGL was found to have anti-inflammatory properties with the inhibition of nitric oxide (NO), pro-inflammatory cytokine production, and MAPK signaling in LPS-induced RAW 264.7 macrophages. Moreover, treatment of RAW 264.7 macrophage with EGL inhibited LPS-induced IL-1β production in a dose-dependent manner. These inhibitory effects were found with the blockage of p38 mitogen-activated protein kinases (MAPK), extracellular signal regulated kinases 1 and 2 (ERK1/2), and also c-Jun N-terminal kinases 1 and 2 (JNK1/2). These results indicated that anti-inflammatory actions of EGL in RAW 264.7 macrophages involved in the inhibition of LPS-induced p38MAPK/ERK/JNK signaling pathways. In addition, our findings suggest that EGL holds great promise for use in the treatment of various inflammatory diseases. |
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Grateloupia lanceolata is a red alga native to coastal areas of East Asia. In this study, extract from G. lanceolata (EGL) was investigated for suppressive effects on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages. EGL was found to have anti-inflammatory properties with the inhibition of nitric oxide (NO), pro-inflammatory cytokine production, and MAPK signaling in LPS-induced RAW 264.7 macrophages. Moreover, treatment of RAW 264.7 macrophage with EGL inhibited LPS-induced IL-1β production in a dose-dependent manner. These inhibitory effects were found with the blockage of p38 mitogen-activated protein kinases (MAPK), extracellular signal regulated kinases 1 and 2 (ERK1/2), and also c-Jun N-terminal kinases 1 and 2 (JNK1/2). These results indicated that anti-inflammatory actions of EGL in RAW 264.7 macrophages involved in the inhibition of LPS-induced p38MAPK/ERK/JNK signaling pathways. In addition, our findings suggest that EGL holds great promise for use in the treatment of various inflammatory diseases. |
| abstract_unstemmed |
Grateloupia lanceolata is a red alga native to coastal areas of East Asia. In this study, extract from G. lanceolata (EGL) was investigated for suppressive effects on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages. EGL was found to have anti-inflammatory properties with the inhibition of nitric oxide (NO), pro-inflammatory cytokine production, and MAPK signaling in LPS-induced RAW 264.7 macrophages. Moreover, treatment of RAW 264.7 macrophage with EGL inhibited LPS-induced IL-1β production in a dose-dependent manner. These inhibitory effects were found with the blockage of p38 mitogen-activated protein kinases (MAPK), extracellular signal regulated kinases 1 and 2 (ERK1/2), and also c-Jun N-terminal kinases 1 and 2 (JNK1/2). These results indicated that anti-inflammatory actions of EGL in RAW 264.7 macrophages involved in the inhibition of LPS-induced p38MAPK/ERK/JNK signaling pathways. In addition, our findings suggest that EGL holds great promise for use in the treatment of various inflammatory diseases. |
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Inhibitory Effects of Extract from G. lanceolata on LPS-Induced Production of Nitric Oxide and IL-1β via Down-regulation of MAPK in Macrophages |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a2200265 4500</leader><controlfield tag="001">OLC1967120846</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20220221022429.0</controlfield><controlfield tag="007">tu</controlfield><controlfield tag="008">160206s2015 xx ||||| 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s12010-014-1301-8</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">PQ20160617</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)OLC1967120846</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBVOLC1967120846</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(PRQ)c1922-6164b92e85c5a8ceb60008020e85c47f4b9bca9fac3042c1e44ca8f9a7e8a02a0</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(KEY)0068751020150000175000200657inhibitoryeffectsofextractfromglanceolataonlpsindu</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">570</subfield><subfield code="a">540</subfield><subfield code="a">660</subfield><subfield code="q">DNB</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">42.00</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Kim, Dong Hwan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Inhibitory Effects of Extract from G. lanceolata on LPS-Induced Production of Nitric Oxide and IL-1β via Down-regulation of MAPK in Macrophages</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2015</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">ohne Hilfsmittel zu benutzen</subfield><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Band</subfield><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Grateloupia lanceolata is a red alga native to coastal areas of East Asia. In this study, extract from G. lanceolata (EGL) was investigated for suppressive effects on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages. EGL was found to have anti-inflammatory properties with the inhibition of nitric oxide (NO), pro-inflammatory cytokine production, and MAPK signaling in LPS-induced RAW 264.7 macrophages. Moreover, treatment of RAW 264.7 macrophage with EGL inhibited LPS-induced IL-1β production in a dose-dependent manner. These inhibitory effects were found with the blockage of p38 mitogen-activated protein kinases (MAPK), extracellular signal regulated kinases 1 and 2 (ERK1/2), and also c-Jun N-terminal kinases 1 and 2 (JNK1/2). These results indicated that anti-inflammatory actions of EGL in RAW 264.7 macrophages involved in the inhibition of LPS-induced p38MAPK/ERK/JNK signaling pathways. In addition, our findings suggest that EGL holds great promise for use in the treatment of various inflammatory diseases.</subfield></datafield><datafield tag="540" ind1=" " ind2=" "><subfield code="a">Nutzungsrecht: © Springer Science+Business Media New York 2015</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Biochemistry, general</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Chemistry</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Macrophage</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">MAPK signaling</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Extract from Grateloupia lanceolata</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Biotechnology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Inflammation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Rhodophyta - 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