Ecotoxicity of ketoprofen, diclofenac, atenolol and their photolysis byproducts in zebrafish (Danio rerio)
The occurrence of pharmaceutical compounds in wastewater treatment plants and surface waters has been detected worldwide, constituting a potential risk for aquatic ecosystems. Adult zebrafish, of both sexes, were exposed to three common pharmaceutical compounds (atenolol, ketoprofen and diclofenac)...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Diniz, M S [verfasserIn] |
|---|
| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Rechteinformationen: |
Nutzungsrecht: Copyright © 2014 Elsevier B.V. All rights reserved. |
|---|
| Schlagwörter: |
Glutathione Transferase - metabolism Superoxide Dismutase - metabolism |
|---|
| Übergeordnetes Werk: |
Enthalten in: The science of the total environment - Amsterdam : Elsevier, 1972, 505(2015), Seite 282-289 |
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| Übergeordnetes Werk: |
volume:505 ; year:2015 ; pages:282-289 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.scitotenv.2014.09.103 |
|---|
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OLC1967432856 |
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| 520 | |a The occurrence of pharmaceutical compounds in wastewater treatment plants and surface waters has been detected worldwide, constituting a potential risk for aquatic ecosystems. Adult zebrafish, of both sexes, were exposed to three common pharmaceutical compounds (atenolol, ketoprofen and diclofenac) and their UV photolysis by-products over seven days. The results show that diclofenac was removed to concentrations<LOD after 5 min of UV irradiation. The oxidative stress response of zebrafish to pharmaceuticals and their photolysis by-products was evaluated through oxidative stress enzymes (glutathione-S-transferase, catalase, superoxide dismutase) and lipid peroxidation. Results suggest that the photolysis by-products of diclofenac were more toxic than those from the other compounds tested, showing an increase in GST and CAT levels, which are also supported by higher MDA levels. Overall, the toxicity of waters containing atenolol and ketoprofen was reduced after the parent compounds were transformed by photolysis, whereas the toxicity increased significantly from the by-products generated through diclofenac photolysis. Therefore, diclofenac photolysis would possibly necessitate higher irradiation time to ensure that the associated by-products are completely degraded to harmless form(s). | ||
| 540 | |a Nutzungsrecht: Copyright © 2014 Elsevier B.V. All rights reserved. | ||
| 650 | 4 | |a Zebrafish - metabolism | |
| 650 | 4 | |a Glutathione Transferase - metabolism | |
| 650 | 4 | |a Superoxide Dismutase - metabolism | |
| 650 | 4 | |a Water Pollutants, Chemical - toxicity | |
| 650 | 4 | |a Diclofenac - toxicity | |
| 650 | 4 | |a Atenolol - toxicity | |
| 650 | 4 | |a Waste Water - chemistry | |
| 650 | 4 | |a Ketoprofen - toxicity | |
| 650 | 4 | |a Catalase - metabolism | |
| 650 | 4 | |a Ketoprofen - metabolism | |
| 650 | 4 | |a Diclofenac - metabolism | |
| 650 | 4 | |a Atenolol - metabolism | |
| 650 | 4 | |a Water Pollutants, Chemical - metabolism | |
| 700 | 1 | |a Salgado, R |4 oth | |
| 700 | 1 | |a Pereira, V J |4 oth | |
| 700 | 1 | |a Carvalho, G |4 oth | |
| 700 | 1 | |a Oehmen, A |4 oth | |
| 700 | 1 | |a Reis, M A M |4 oth | |
| 700 | 1 | |a Noronha, J P |4 oth | |
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10.1016/j.scitotenv.2014.09.103 doi PQ20160617 (DE-627)OLC1967432856 (DE-599)GBVOLC1967432856 (PRQ)c1849-abbc67fb074ec48ce5b625edede6eb0efa299896e35c9464870d784aa846e7b00 (KEY)0073664320150000505000000282ecotoxicityofketoprofendiclofenacatenololandtheirp DE-627 ger DE-627 rakwb eng 570 333.7 610 DNB Diniz, M S verfasserin aut Ecotoxicity of ketoprofen, diclofenac, atenolol and their photolysis byproducts in zebrafish (Danio rerio) 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The occurrence of pharmaceutical compounds in wastewater treatment plants and surface waters has been detected worldwide, constituting a potential risk for aquatic ecosystems. Adult zebrafish, of both sexes, were exposed to three common pharmaceutical compounds (atenolol, ketoprofen and diclofenac) and their UV photolysis by-products over seven days. The results show that diclofenac was removed to concentrations<LOD after 5 min of UV irradiation. The oxidative stress response of zebrafish to pharmaceuticals and their photolysis by-products was evaluated through oxidative stress enzymes (glutathione-S-transferase, catalase, superoxide dismutase) and lipid peroxidation. Results suggest that the photolysis by-products of diclofenac were more toxic than those from the other compounds tested, showing an increase in GST and CAT levels, which are also supported by higher MDA levels. Overall, the toxicity of waters containing atenolol and ketoprofen was reduced after the parent compounds were transformed by photolysis, whereas the toxicity increased significantly from the by-products generated through diclofenac photolysis. Therefore, diclofenac photolysis would possibly necessitate higher irradiation time to ensure that the associated by-products are completely degraded to harmless form(s). Nutzungsrecht: Copyright © 2014 Elsevier B.V. All rights reserved. Zebrafish - metabolism Glutathione Transferase - metabolism Superoxide Dismutase - metabolism Water Pollutants, Chemical - toxicity Diclofenac - toxicity Atenolol - toxicity Waste Water - chemistry Ketoprofen - toxicity Catalase - metabolism Ketoprofen - metabolism Diclofenac - metabolism Atenolol - metabolism Water Pollutants, Chemical - metabolism Salgado, R oth Pereira, V J oth Carvalho, G oth Oehmen, A oth Reis, M A M oth Noronha, J P oth Enthalten in The science of the total environment Amsterdam : Elsevier, 1972 505(2015), Seite 282-289 (DE-627)129297917 (DE-600)121506-1 (DE-576)014490919 0048-9697 nnns volume:505 year:2015 pages:282-289 http://dx.doi.org/10.1016/j.scitotenv.2014.09.103 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25461029 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-FOR SSG-OPC-GGO GBV_ILN_21 GBV_ILN_70 GBV_ILN_4012 AR 505 2015 282-289 |
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10.1016/j.scitotenv.2014.09.103 doi PQ20160617 (DE-627)OLC1967432856 (DE-599)GBVOLC1967432856 (PRQ)c1849-abbc67fb074ec48ce5b625edede6eb0efa299896e35c9464870d784aa846e7b00 (KEY)0073664320150000505000000282ecotoxicityofketoprofendiclofenacatenololandtheirp DE-627 ger DE-627 rakwb eng 570 333.7 610 DNB Diniz, M S verfasserin aut Ecotoxicity of ketoprofen, diclofenac, atenolol and their photolysis byproducts in zebrafish (Danio rerio) 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The occurrence of pharmaceutical compounds in wastewater treatment plants and surface waters has been detected worldwide, constituting a potential risk for aquatic ecosystems. Adult zebrafish, of both sexes, were exposed to three common pharmaceutical compounds (atenolol, ketoprofen and diclofenac) and their UV photolysis by-products over seven days. The results show that diclofenac was removed to concentrations<LOD after 5 min of UV irradiation. The oxidative stress response of zebrafish to pharmaceuticals and their photolysis by-products was evaluated through oxidative stress enzymes (glutathione-S-transferase, catalase, superoxide dismutase) and lipid peroxidation. Results suggest that the photolysis by-products of diclofenac were more toxic than those from the other compounds tested, showing an increase in GST and CAT levels, which are also supported by higher MDA levels. Overall, the toxicity of waters containing atenolol and ketoprofen was reduced after the parent compounds were transformed by photolysis, whereas the toxicity increased significantly from the by-products generated through diclofenac photolysis. Therefore, diclofenac photolysis would possibly necessitate higher irradiation time to ensure that the associated by-products are completely degraded to harmless form(s). Nutzungsrecht: Copyright © 2014 Elsevier B.V. All rights reserved. Zebrafish - metabolism Glutathione Transferase - metabolism Superoxide Dismutase - metabolism Water Pollutants, Chemical - toxicity Diclofenac - toxicity Atenolol - toxicity Waste Water - chemistry Ketoprofen - toxicity Catalase - metabolism Ketoprofen - metabolism Diclofenac - metabolism Atenolol - metabolism Water Pollutants, Chemical - metabolism Salgado, R oth Pereira, V J oth Carvalho, G oth Oehmen, A oth Reis, M A M oth Noronha, J P oth Enthalten in The science of the total environment Amsterdam : Elsevier, 1972 505(2015), Seite 282-289 (DE-627)129297917 (DE-600)121506-1 (DE-576)014490919 0048-9697 nnns volume:505 year:2015 pages:282-289 http://dx.doi.org/10.1016/j.scitotenv.2014.09.103 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25461029 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-FOR SSG-OPC-GGO GBV_ILN_21 GBV_ILN_70 GBV_ILN_4012 AR 505 2015 282-289 |
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10.1016/j.scitotenv.2014.09.103 doi PQ20160617 (DE-627)OLC1967432856 (DE-599)GBVOLC1967432856 (PRQ)c1849-abbc67fb074ec48ce5b625edede6eb0efa299896e35c9464870d784aa846e7b00 (KEY)0073664320150000505000000282ecotoxicityofketoprofendiclofenacatenololandtheirp DE-627 ger DE-627 rakwb eng 570 333.7 610 DNB Diniz, M S verfasserin aut Ecotoxicity of ketoprofen, diclofenac, atenolol and their photolysis byproducts in zebrafish (Danio rerio) 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The occurrence of pharmaceutical compounds in wastewater treatment plants and surface waters has been detected worldwide, constituting a potential risk for aquatic ecosystems. Adult zebrafish, of both sexes, were exposed to three common pharmaceutical compounds (atenolol, ketoprofen and diclofenac) and their UV photolysis by-products over seven days. The results show that diclofenac was removed to concentrations<LOD after 5 min of UV irradiation. The oxidative stress response of zebrafish to pharmaceuticals and their photolysis by-products was evaluated through oxidative stress enzymes (glutathione-S-transferase, catalase, superoxide dismutase) and lipid peroxidation. Results suggest that the photolysis by-products of diclofenac were more toxic than those from the other compounds tested, showing an increase in GST and CAT levels, which are also supported by higher MDA levels. Overall, the toxicity of waters containing atenolol and ketoprofen was reduced after the parent compounds were transformed by photolysis, whereas the toxicity increased significantly from the by-products generated through diclofenac photolysis. Therefore, diclofenac photolysis would possibly necessitate higher irradiation time to ensure that the associated by-products are completely degraded to harmless form(s). Nutzungsrecht: Copyright © 2014 Elsevier B.V. All rights reserved. Zebrafish - metabolism Glutathione Transferase - metabolism Superoxide Dismutase - metabolism Water Pollutants, Chemical - toxicity Diclofenac - toxicity Atenolol - toxicity Waste Water - chemistry Ketoprofen - toxicity Catalase - metabolism Ketoprofen - metabolism Diclofenac - metabolism Atenolol - metabolism Water Pollutants, Chemical - metabolism Salgado, R oth Pereira, V J oth Carvalho, G oth Oehmen, A oth Reis, M A M oth Noronha, J P oth Enthalten in The science of the total environment Amsterdam : Elsevier, 1972 505(2015), Seite 282-289 (DE-627)129297917 (DE-600)121506-1 (DE-576)014490919 0048-9697 nnns volume:505 year:2015 pages:282-289 http://dx.doi.org/10.1016/j.scitotenv.2014.09.103 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25461029 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-FOR SSG-OPC-GGO GBV_ILN_21 GBV_ILN_70 GBV_ILN_4012 AR 505 2015 282-289 |
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10.1016/j.scitotenv.2014.09.103 doi PQ20160617 (DE-627)OLC1967432856 (DE-599)GBVOLC1967432856 (PRQ)c1849-abbc67fb074ec48ce5b625edede6eb0efa299896e35c9464870d784aa846e7b00 (KEY)0073664320150000505000000282ecotoxicityofketoprofendiclofenacatenololandtheirp DE-627 ger DE-627 rakwb eng 570 333.7 610 DNB Diniz, M S verfasserin aut Ecotoxicity of ketoprofen, diclofenac, atenolol and their photolysis byproducts in zebrafish (Danio rerio) 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The occurrence of pharmaceutical compounds in wastewater treatment plants and surface waters has been detected worldwide, constituting a potential risk for aquatic ecosystems. Adult zebrafish, of both sexes, were exposed to three common pharmaceutical compounds (atenolol, ketoprofen and diclofenac) and their UV photolysis by-products over seven days. The results show that diclofenac was removed to concentrations<LOD after 5 min of UV irradiation. The oxidative stress response of zebrafish to pharmaceuticals and their photolysis by-products was evaluated through oxidative stress enzymes (glutathione-S-transferase, catalase, superoxide dismutase) and lipid peroxidation. Results suggest that the photolysis by-products of diclofenac were more toxic than those from the other compounds tested, showing an increase in GST and CAT levels, which are also supported by higher MDA levels. Overall, the toxicity of waters containing atenolol and ketoprofen was reduced after the parent compounds were transformed by photolysis, whereas the toxicity increased significantly from the by-products generated through diclofenac photolysis. Therefore, diclofenac photolysis would possibly necessitate higher irradiation time to ensure that the associated by-products are completely degraded to harmless form(s). Nutzungsrecht: Copyright © 2014 Elsevier B.V. All rights reserved. Zebrafish - metabolism Glutathione Transferase - metabolism Superoxide Dismutase - metabolism Water Pollutants, Chemical - toxicity Diclofenac - toxicity Atenolol - toxicity Waste Water - chemistry Ketoprofen - toxicity Catalase - metabolism Ketoprofen - metabolism Diclofenac - metabolism Atenolol - metabolism Water Pollutants, Chemical - metabolism Salgado, R oth Pereira, V J oth Carvalho, G oth Oehmen, A oth Reis, M A M oth Noronha, J P oth Enthalten in The science of the total environment Amsterdam : Elsevier, 1972 505(2015), Seite 282-289 (DE-627)129297917 (DE-600)121506-1 (DE-576)014490919 0048-9697 nnns volume:505 year:2015 pages:282-289 http://dx.doi.org/10.1016/j.scitotenv.2014.09.103 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25461029 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-FOR SSG-OPC-GGO GBV_ILN_21 GBV_ILN_70 GBV_ILN_4012 AR 505 2015 282-289 |
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10.1016/j.scitotenv.2014.09.103 doi PQ20160617 (DE-627)OLC1967432856 (DE-599)GBVOLC1967432856 (PRQ)c1849-abbc67fb074ec48ce5b625edede6eb0efa299896e35c9464870d784aa846e7b00 (KEY)0073664320150000505000000282ecotoxicityofketoprofendiclofenacatenololandtheirp DE-627 ger DE-627 rakwb eng 570 333.7 610 DNB Diniz, M S verfasserin aut Ecotoxicity of ketoprofen, diclofenac, atenolol and their photolysis byproducts in zebrafish (Danio rerio) 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The occurrence of pharmaceutical compounds in wastewater treatment plants and surface waters has been detected worldwide, constituting a potential risk for aquatic ecosystems. Adult zebrafish, of both sexes, were exposed to three common pharmaceutical compounds (atenolol, ketoprofen and diclofenac) and their UV photolysis by-products over seven days. The results show that diclofenac was removed to concentrations<LOD after 5 min of UV irradiation. The oxidative stress response of zebrafish to pharmaceuticals and their photolysis by-products was evaluated through oxidative stress enzymes (glutathione-S-transferase, catalase, superoxide dismutase) and lipid peroxidation. Results suggest that the photolysis by-products of diclofenac were more toxic than those from the other compounds tested, showing an increase in GST and CAT levels, which are also supported by higher MDA levels. Overall, the toxicity of waters containing atenolol and ketoprofen was reduced after the parent compounds were transformed by photolysis, whereas the toxicity increased significantly from the by-products generated through diclofenac photolysis. Therefore, diclofenac photolysis would possibly necessitate higher irradiation time to ensure that the associated by-products are completely degraded to harmless form(s). Nutzungsrecht: Copyright © 2014 Elsevier B.V. All rights reserved. Zebrafish - metabolism Glutathione Transferase - metabolism Superoxide Dismutase - metabolism Water Pollutants, Chemical - toxicity Diclofenac - toxicity Atenolol - toxicity Waste Water - chemistry Ketoprofen - toxicity Catalase - metabolism Ketoprofen - metabolism Diclofenac - metabolism Atenolol - metabolism Water Pollutants, Chemical - metabolism Salgado, R oth Pereira, V J oth Carvalho, G oth Oehmen, A oth Reis, M A M oth Noronha, J P oth Enthalten in The science of the total environment Amsterdam : Elsevier, 1972 505(2015), Seite 282-289 (DE-627)129297917 (DE-600)121506-1 (DE-576)014490919 0048-9697 nnns volume:505 year:2015 pages:282-289 http://dx.doi.org/10.1016/j.scitotenv.2014.09.103 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25461029 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-FOR SSG-OPC-GGO GBV_ILN_21 GBV_ILN_70 GBV_ILN_4012 AR 505 2015 282-289 |
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Diniz, M S ddc 570 misc Zebrafish - metabolism misc Glutathione Transferase - metabolism misc Superoxide Dismutase - metabolism misc Water Pollutants, Chemical - toxicity misc Diclofenac - toxicity misc Atenolol - toxicity misc Waste Water - chemistry misc Ketoprofen - toxicity misc Catalase - metabolism misc Ketoprofen - metabolism misc Diclofenac - metabolism misc Atenolol - metabolism misc Water Pollutants, Chemical - metabolism Ecotoxicity of ketoprofen, diclofenac, atenolol and their photolysis byproducts in zebrafish (Danio rerio) |
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570 333.7 610 DNB Ecotoxicity of ketoprofen, diclofenac, atenolol and their photolysis byproducts in zebrafish (Danio rerio) Zebrafish - metabolism Glutathione Transferase - metabolism Superoxide Dismutase - metabolism Water Pollutants, Chemical - toxicity Diclofenac - toxicity Atenolol - toxicity Waste Water - chemistry Ketoprofen - toxicity Catalase - metabolism Ketoprofen - metabolism Diclofenac - metabolism Atenolol - metabolism Water Pollutants, Chemical - metabolism |
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Ecotoxicity of ketoprofen, diclofenac, atenolol and their photolysis byproducts in zebrafish (Danio rerio) |
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Ecotoxicity of ketoprofen, diclofenac, atenolol and their photolysis byproducts in zebrafish (Danio rerio) |
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ecotoxicity of ketoprofen, diclofenac, atenolol and their photolysis byproducts in zebrafish (danio rerio) |
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Ecotoxicity of ketoprofen, diclofenac, atenolol and their photolysis byproducts in zebrafish (Danio rerio) |
| abstract |
The occurrence of pharmaceutical compounds in wastewater treatment plants and surface waters has been detected worldwide, constituting a potential risk for aquatic ecosystems. Adult zebrafish, of both sexes, were exposed to three common pharmaceutical compounds (atenolol, ketoprofen and diclofenac) and their UV photolysis by-products over seven days. The results show that diclofenac was removed to concentrations<LOD after 5 min of UV irradiation. The oxidative stress response of zebrafish to pharmaceuticals and their photolysis by-products was evaluated through oxidative stress enzymes (glutathione-S-transferase, catalase, superoxide dismutase) and lipid peroxidation. Results suggest that the photolysis by-products of diclofenac were more toxic than those from the other compounds tested, showing an increase in GST and CAT levels, which are also supported by higher MDA levels. Overall, the toxicity of waters containing atenolol and ketoprofen was reduced after the parent compounds were transformed by photolysis, whereas the toxicity increased significantly from the by-products generated through diclofenac photolysis. Therefore, diclofenac photolysis would possibly necessitate higher irradiation time to ensure that the associated by-products are completely degraded to harmless form(s). |
| abstractGer |
The occurrence of pharmaceutical compounds in wastewater treatment plants and surface waters has been detected worldwide, constituting a potential risk for aquatic ecosystems. Adult zebrafish, of both sexes, were exposed to three common pharmaceutical compounds (atenolol, ketoprofen and diclofenac) and their UV photolysis by-products over seven days. The results show that diclofenac was removed to concentrations<LOD after 5 min of UV irradiation. The oxidative stress response of zebrafish to pharmaceuticals and their photolysis by-products was evaluated through oxidative stress enzymes (glutathione-S-transferase, catalase, superoxide dismutase) and lipid peroxidation. Results suggest that the photolysis by-products of diclofenac were more toxic than those from the other compounds tested, showing an increase in GST and CAT levels, which are also supported by higher MDA levels. Overall, the toxicity of waters containing atenolol and ketoprofen was reduced after the parent compounds were transformed by photolysis, whereas the toxicity increased significantly from the by-products generated through diclofenac photolysis. Therefore, diclofenac photolysis would possibly necessitate higher irradiation time to ensure that the associated by-products are completely degraded to harmless form(s). |
| abstract_unstemmed |
The occurrence of pharmaceutical compounds in wastewater treatment plants and surface waters has been detected worldwide, constituting a potential risk for aquatic ecosystems. Adult zebrafish, of both sexes, were exposed to three common pharmaceutical compounds (atenolol, ketoprofen and diclofenac) and their UV photolysis by-products over seven days. The results show that diclofenac was removed to concentrations<LOD after 5 min of UV irradiation. The oxidative stress response of zebrafish to pharmaceuticals and their photolysis by-products was evaluated through oxidative stress enzymes (glutathione-S-transferase, catalase, superoxide dismutase) and lipid peroxidation. Results suggest that the photolysis by-products of diclofenac were more toxic than those from the other compounds tested, showing an increase in GST and CAT levels, which are also supported by higher MDA levels. Overall, the toxicity of waters containing atenolol and ketoprofen was reduced after the parent compounds were transformed by photolysis, whereas the toxicity increased significantly from the by-products generated through diclofenac photolysis. Therefore, diclofenac photolysis would possibly necessitate higher irradiation time to ensure that the associated by-products are completely degraded to harmless form(s). |
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| title_short |
Ecotoxicity of ketoprofen, diclofenac, atenolol and their photolysis byproducts in zebrafish (Danio rerio) |
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http://dx.doi.org/10.1016/j.scitotenv.2014.09.103 http://www.ncbi.nlm.nih.gov/pubmed/25461029 |
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