Effects of recombinant IL‐17F intranasal inoculation against Streptococcus pneumoniae infection in a murine model
Interleukin‐17F (IL‐17F) is an important member of IL‐17 cytokine family, which plays important roles in host defense against microbial infections. Streptococcus pneumoniae is a common pathogen associated with several invasive and noninvasive pneumococcal diseases, and mucosal immune response plays...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Chen, Ling [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Rechteinformationen: |
Nutzungsrecht: © 2014 International Union of Biochemistry and Molecular Biology, Inc. |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Biotechnology & applied biochemistry - Hoboken, NJ : Wiley-Blackwell, 1986, 62(2015), 3, Seite 393-400 |
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| Übergeordnetes Werk: |
volume:62 ; year:2015 ; number:3 ; pages:393-400 |
| Links: |
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| DOI / URN: |
10.1002/bab.1286 |
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OLC1968381287 |
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| 520 | |a Interleukin‐17F (IL‐17F) is an important member of IL‐17 cytokine family, which plays important roles in host defense against microbial infections. Streptococcus pneumoniae is a common pathogen associated with several invasive and noninvasive pneumococcal diseases, and mucosal immune response plays crucial roles in defenses against pneumococcal infection. Thus, intranasal inoculation may be an alternative approach against pneumococci. In this study, BALB/c mice were intranasally inoculated with recombinant IL‐17F (rIL‐17F) prior to S. pneumoniae (American Type Culture Collection 6303, serotype 3) infection. As compared with the control group, numbers of total leukocyte, neutrophil, and macrophage in lungs were significantly increased in mice inoculated with rIL‐17F. The levels of macrophage inflammatory protein 1α (MIP‐1α), MIP‐2β, and interferon γ were significantly increased in bronchoalveolar lavage fluid and culture supernatant of splenocytes from mice inoculated with rIL‐17F. rIL‐17F inoculation also significantly elevated β‐defensin‐2 expression in lung tissues. Furthermore, compared with S. pneumoniae infection group, rIL‐17F inoculation prior to infection significantly reduced S. pneumoniae colonization in lungs. These findings demonstrated that rIL‐17F intranasal inoculation strengthened host defense against pneumococci, which may be developed to prevent pneumococcal infection. | ||
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| 650 | 4 | |a β‐defensin‐2 | |
| 650 | 4 | |a inflammation | |
| 650 | 4 | |a Streptococcus pneumoniae | |
| 650 | 4 | |a interleukin‐17F | |
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| 650 | 4 | |a Pneumonia | |
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| 700 | 1 | |a Zhang, Jianhua |4 oth | |
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10.1002/bab.1286 doi PQ20160617 (DE-627)OLC1968381287 (DE-599)GBVOLC1968381287 (PRQ)p2306-c110703722e37f29adb18f64cacd05210c00387fae5e6070d7ef434b7ea3d4560 (KEY)0100570720150000062000300393effectsofrecombinantil17fintranasalinoculationagai DE-627 ger DE-627 rakwb eng 570 ZDB Chen, Ling verfasserin aut Effects of recombinant IL‐17F intranasal inoculation against Streptococcus pneumoniae infection in a murine model 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Interleukin‐17F (IL‐17F) is an important member of IL‐17 cytokine family, which plays important roles in host defense against microbial infections. Streptococcus pneumoniae is a common pathogen associated with several invasive and noninvasive pneumococcal diseases, and mucosal immune response plays crucial roles in defenses against pneumococcal infection. Thus, intranasal inoculation may be an alternative approach against pneumococci. In this study, BALB/c mice were intranasally inoculated with recombinant IL‐17F (rIL‐17F) prior to S. pneumoniae (American Type Culture Collection 6303, serotype 3) infection. As compared with the control group, numbers of total leukocyte, neutrophil, and macrophage in lungs were significantly increased in mice inoculated with rIL‐17F. The levels of macrophage inflammatory protein 1α (MIP‐1α), MIP‐2β, and interferon γ were significantly increased in bronchoalveolar lavage fluid and culture supernatant of splenocytes from mice inoculated with rIL‐17F. rIL‐17F inoculation also significantly elevated β‐defensin‐2 expression in lung tissues. Furthermore, compared with S. pneumoniae infection group, rIL‐17F inoculation prior to infection significantly reduced S. pneumoniae colonization in lungs. These findings demonstrated that rIL‐17F intranasal inoculation strengthened host defense against pneumococci, which may be developed to prevent pneumococcal infection. Nutzungsrecht: © 2014 International Union of Biochemistry and Molecular Biology, Inc. β‐defensin‐2 inflammation Streptococcus pneumoniae interleukin‐17F Streptococcus infections Pneumonia Rodents Guo, Sheng oth Wu, Liangxia oth Hao, Chunli oth Xu, Wanting oth Zhang, Jianhua oth Enthalten in Biotechnology & applied biochemistry Hoboken, NJ : Wiley-Blackwell, 1986 62(2015), 3, Seite 393-400 (DE-627)130679461 (DE-600)883433-7 (DE-576)018288111 0885-4513 nnns volume:62 year:2015 number:3 pages:393-400 http://dx.doi.org/10.1002/bab.1286 Volltext http://onlinelibrary.wiley.com/doi/10.1002/bab.1286/abstract http://www.ncbi.nlm.nih.gov/pubmed/25196250 http://search.proquest.com/docview/1689681995 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 GBV_ILN_4012 GBV_ILN_4310 AR 62 2015 3 393-400 |
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10.1002/bab.1286 doi PQ20160617 (DE-627)OLC1968381287 (DE-599)GBVOLC1968381287 (PRQ)p2306-c110703722e37f29adb18f64cacd05210c00387fae5e6070d7ef434b7ea3d4560 (KEY)0100570720150000062000300393effectsofrecombinantil17fintranasalinoculationagai DE-627 ger DE-627 rakwb eng 570 ZDB Chen, Ling verfasserin aut Effects of recombinant IL‐17F intranasal inoculation against Streptococcus pneumoniae infection in a murine model 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Interleukin‐17F (IL‐17F) is an important member of IL‐17 cytokine family, which plays important roles in host defense against microbial infections. Streptococcus pneumoniae is a common pathogen associated with several invasive and noninvasive pneumococcal diseases, and mucosal immune response plays crucial roles in defenses against pneumococcal infection. Thus, intranasal inoculation may be an alternative approach against pneumococci. In this study, BALB/c mice were intranasally inoculated with recombinant IL‐17F (rIL‐17F) prior to S. pneumoniae (American Type Culture Collection 6303, serotype 3) infection. As compared with the control group, numbers of total leukocyte, neutrophil, and macrophage in lungs were significantly increased in mice inoculated with rIL‐17F. The levels of macrophage inflammatory protein 1α (MIP‐1α), MIP‐2β, and interferon γ were significantly increased in bronchoalveolar lavage fluid and culture supernatant of splenocytes from mice inoculated with rIL‐17F. rIL‐17F inoculation also significantly elevated β‐defensin‐2 expression in lung tissues. Furthermore, compared with S. pneumoniae infection group, rIL‐17F inoculation prior to infection significantly reduced S. pneumoniae colonization in lungs. These findings demonstrated that rIL‐17F intranasal inoculation strengthened host defense against pneumococci, which may be developed to prevent pneumococcal infection. Nutzungsrecht: © 2014 International Union of Biochemistry and Molecular Biology, Inc. β‐defensin‐2 inflammation Streptococcus pneumoniae interleukin‐17F Streptococcus infections Pneumonia Rodents Guo, Sheng oth Wu, Liangxia oth Hao, Chunli oth Xu, Wanting oth Zhang, Jianhua oth Enthalten in Biotechnology & applied biochemistry Hoboken, NJ : Wiley-Blackwell, 1986 62(2015), 3, Seite 393-400 (DE-627)130679461 (DE-600)883433-7 (DE-576)018288111 0885-4513 nnns volume:62 year:2015 number:3 pages:393-400 http://dx.doi.org/10.1002/bab.1286 Volltext http://onlinelibrary.wiley.com/doi/10.1002/bab.1286/abstract http://www.ncbi.nlm.nih.gov/pubmed/25196250 http://search.proquest.com/docview/1689681995 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 GBV_ILN_4012 GBV_ILN_4310 AR 62 2015 3 393-400 |
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10.1002/bab.1286 doi PQ20160617 (DE-627)OLC1968381287 (DE-599)GBVOLC1968381287 (PRQ)p2306-c110703722e37f29adb18f64cacd05210c00387fae5e6070d7ef434b7ea3d4560 (KEY)0100570720150000062000300393effectsofrecombinantil17fintranasalinoculationagai DE-627 ger DE-627 rakwb eng 570 ZDB Chen, Ling verfasserin aut Effects of recombinant IL‐17F intranasal inoculation against Streptococcus pneumoniae infection in a murine model 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Interleukin‐17F (IL‐17F) is an important member of IL‐17 cytokine family, which plays important roles in host defense against microbial infections. Streptococcus pneumoniae is a common pathogen associated with several invasive and noninvasive pneumococcal diseases, and mucosal immune response plays crucial roles in defenses against pneumococcal infection. Thus, intranasal inoculation may be an alternative approach against pneumococci. In this study, BALB/c mice were intranasally inoculated with recombinant IL‐17F (rIL‐17F) prior to S. pneumoniae (American Type Culture Collection 6303, serotype 3) infection. As compared with the control group, numbers of total leukocyte, neutrophil, and macrophage in lungs were significantly increased in mice inoculated with rIL‐17F. The levels of macrophage inflammatory protein 1α (MIP‐1α), MIP‐2β, and interferon γ were significantly increased in bronchoalveolar lavage fluid and culture supernatant of splenocytes from mice inoculated with rIL‐17F. rIL‐17F inoculation also significantly elevated β‐defensin‐2 expression in lung tissues. Furthermore, compared with S. pneumoniae infection group, rIL‐17F inoculation prior to infection significantly reduced S. pneumoniae colonization in lungs. These findings demonstrated that rIL‐17F intranasal inoculation strengthened host defense against pneumococci, which may be developed to prevent pneumococcal infection. Nutzungsrecht: © 2014 International Union of Biochemistry and Molecular Biology, Inc. β‐defensin‐2 inflammation Streptococcus pneumoniae interleukin‐17F Streptococcus infections Pneumonia Rodents Guo, Sheng oth Wu, Liangxia oth Hao, Chunli oth Xu, Wanting oth Zhang, Jianhua oth Enthalten in Biotechnology & applied biochemistry Hoboken, NJ : Wiley-Blackwell, 1986 62(2015), 3, Seite 393-400 (DE-627)130679461 (DE-600)883433-7 (DE-576)018288111 0885-4513 nnns volume:62 year:2015 number:3 pages:393-400 http://dx.doi.org/10.1002/bab.1286 Volltext http://onlinelibrary.wiley.com/doi/10.1002/bab.1286/abstract http://www.ncbi.nlm.nih.gov/pubmed/25196250 http://search.proquest.com/docview/1689681995 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 GBV_ILN_4012 GBV_ILN_4310 AR 62 2015 3 393-400 |
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10.1002/bab.1286 doi PQ20160617 (DE-627)OLC1968381287 (DE-599)GBVOLC1968381287 (PRQ)p2306-c110703722e37f29adb18f64cacd05210c00387fae5e6070d7ef434b7ea3d4560 (KEY)0100570720150000062000300393effectsofrecombinantil17fintranasalinoculationagai DE-627 ger DE-627 rakwb eng 570 ZDB Chen, Ling verfasserin aut Effects of recombinant IL‐17F intranasal inoculation against Streptococcus pneumoniae infection in a murine model 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Interleukin‐17F (IL‐17F) is an important member of IL‐17 cytokine family, which plays important roles in host defense against microbial infections. Streptococcus pneumoniae is a common pathogen associated with several invasive and noninvasive pneumococcal diseases, and mucosal immune response plays crucial roles in defenses against pneumococcal infection. Thus, intranasal inoculation may be an alternative approach against pneumococci. In this study, BALB/c mice were intranasally inoculated with recombinant IL‐17F (rIL‐17F) prior to S. pneumoniae (American Type Culture Collection 6303, serotype 3) infection. As compared with the control group, numbers of total leukocyte, neutrophil, and macrophage in lungs were significantly increased in mice inoculated with rIL‐17F. The levels of macrophage inflammatory protein 1α (MIP‐1α), MIP‐2β, and interferon γ were significantly increased in bronchoalveolar lavage fluid and culture supernatant of splenocytes from mice inoculated with rIL‐17F. rIL‐17F inoculation also significantly elevated β‐defensin‐2 expression in lung tissues. Furthermore, compared with S. pneumoniae infection group, rIL‐17F inoculation prior to infection significantly reduced S. pneumoniae colonization in lungs. These findings demonstrated that rIL‐17F intranasal inoculation strengthened host defense against pneumococci, which may be developed to prevent pneumococcal infection. Nutzungsrecht: © 2014 International Union of Biochemistry and Molecular Biology, Inc. β‐defensin‐2 inflammation Streptococcus pneumoniae interleukin‐17F Streptococcus infections Pneumonia Rodents Guo, Sheng oth Wu, Liangxia oth Hao, Chunli oth Xu, Wanting oth Zhang, Jianhua oth Enthalten in Biotechnology & applied biochemistry Hoboken, NJ : Wiley-Blackwell, 1986 62(2015), 3, Seite 393-400 (DE-627)130679461 (DE-600)883433-7 (DE-576)018288111 0885-4513 nnns volume:62 year:2015 number:3 pages:393-400 http://dx.doi.org/10.1002/bab.1286 Volltext http://onlinelibrary.wiley.com/doi/10.1002/bab.1286/abstract http://www.ncbi.nlm.nih.gov/pubmed/25196250 http://search.proquest.com/docview/1689681995 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 GBV_ILN_4012 GBV_ILN_4310 AR 62 2015 3 393-400 |
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10.1002/bab.1286 doi PQ20160617 (DE-627)OLC1968381287 (DE-599)GBVOLC1968381287 (PRQ)p2306-c110703722e37f29adb18f64cacd05210c00387fae5e6070d7ef434b7ea3d4560 (KEY)0100570720150000062000300393effectsofrecombinantil17fintranasalinoculationagai DE-627 ger DE-627 rakwb eng 570 ZDB Chen, Ling verfasserin aut Effects of recombinant IL‐17F intranasal inoculation against Streptococcus pneumoniae infection in a murine model 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Interleukin‐17F (IL‐17F) is an important member of IL‐17 cytokine family, which plays important roles in host defense against microbial infections. Streptococcus pneumoniae is a common pathogen associated with several invasive and noninvasive pneumococcal diseases, and mucosal immune response plays crucial roles in defenses against pneumococcal infection. Thus, intranasal inoculation may be an alternative approach against pneumococci. In this study, BALB/c mice were intranasally inoculated with recombinant IL‐17F (rIL‐17F) prior to S. pneumoniae (American Type Culture Collection 6303, serotype 3) infection. As compared with the control group, numbers of total leukocyte, neutrophil, and macrophage in lungs were significantly increased in mice inoculated with rIL‐17F. The levels of macrophage inflammatory protein 1α (MIP‐1α), MIP‐2β, and interferon γ were significantly increased in bronchoalveolar lavage fluid and culture supernatant of splenocytes from mice inoculated with rIL‐17F. rIL‐17F inoculation also significantly elevated β‐defensin‐2 expression in lung tissues. Furthermore, compared with S. pneumoniae infection group, rIL‐17F inoculation prior to infection significantly reduced S. pneumoniae colonization in lungs. These findings demonstrated that rIL‐17F intranasal inoculation strengthened host defense against pneumococci, which may be developed to prevent pneumococcal infection. Nutzungsrecht: © 2014 International Union of Biochemistry and Molecular Biology, Inc. β‐defensin‐2 inflammation Streptococcus pneumoniae interleukin‐17F Streptococcus infections Pneumonia Rodents Guo, Sheng oth Wu, Liangxia oth Hao, Chunli oth Xu, Wanting oth Zhang, Jianhua oth Enthalten in Biotechnology & applied biochemistry Hoboken, NJ : Wiley-Blackwell, 1986 62(2015), 3, Seite 393-400 (DE-627)130679461 (DE-600)883433-7 (DE-576)018288111 0885-4513 nnns volume:62 year:2015 number:3 pages:393-400 http://dx.doi.org/10.1002/bab.1286 Volltext http://onlinelibrary.wiley.com/doi/10.1002/bab.1286/abstract http://www.ncbi.nlm.nih.gov/pubmed/25196250 http://search.proquest.com/docview/1689681995 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 GBV_ILN_4012 GBV_ILN_4310 AR 62 2015 3 393-400 |
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Streptococcus pneumoniae is a common pathogen associated with several invasive and noninvasive pneumococcal diseases, and mucosal immune response plays crucial roles in defenses against pneumococcal infection. Thus, intranasal inoculation may be an alternative approach against pneumococci. In this study, BALB/c mice were intranasally inoculated with recombinant IL‐17F (rIL‐17F) prior to S. pneumoniae (American Type Culture Collection 6303, serotype 3) infection. As compared with the control group, numbers of total leukocyte, neutrophil, and macrophage in lungs were significantly increased in mice inoculated with rIL‐17F. The levels of macrophage inflammatory protein 1α (MIP‐1α), MIP‐2β, and interferon γ were significantly increased in bronchoalveolar lavage fluid and culture supernatant of splenocytes from mice inoculated with rIL‐17F. rIL‐17F inoculation also significantly elevated β‐defensin‐2 expression in lung tissues. Furthermore, compared with S. pneumoniae infection group, rIL‐17F inoculation prior to infection significantly reduced S. pneumoniae colonization in lungs. 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effects of recombinant il‐17f intranasal inoculation against streptococcus pneumoniae infection in a murine model |
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Effects of recombinant IL‐17F intranasal inoculation against Streptococcus pneumoniae infection in a murine model |
| abstract |
Interleukin‐17F (IL‐17F) is an important member of IL‐17 cytokine family, which plays important roles in host defense against microbial infections. Streptococcus pneumoniae is a common pathogen associated with several invasive and noninvasive pneumococcal diseases, and mucosal immune response plays crucial roles in defenses against pneumococcal infection. Thus, intranasal inoculation may be an alternative approach against pneumococci. In this study, BALB/c mice were intranasally inoculated with recombinant IL‐17F (rIL‐17F) prior to S. pneumoniae (American Type Culture Collection 6303, serotype 3) infection. As compared with the control group, numbers of total leukocyte, neutrophil, and macrophage in lungs were significantly increased in mice inoculated with rIL‐17F. The levels of macrophage inflammatory protein 1α (MIP‐1α), MIP‐2β, and interferon γ were significantly increased in bronchoalveolar lavage fluid and culture supernatant of splenocytes from mice inoculated with rIL‐17F. rIL‐17F inoculation also significantly elevated β‐defensin‐2 expression in lung tissues. Furthermore, compared with S. pneumoniae infection group, rIL‐17F inoculation prior to infection significantly reduced S. pneumoniae colonization in lungs. These findings demonstrated that rIL‐17F intranasal inoculation strengthened host defense against pneumococci, which may be developed to prevent pneumococcal infection. |
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Interleukin‐17F (IL‐17F) is an important member of IL‐17 cytokine family, which plays important roles in host defense against microbial infections. Streptococcus pneumoniae is a common pathogen associated with several invasive and noninvasive pneumococcal diseases, and mucosal immune response plays crucial roles in defenses against pneumococcal infection. Thus, intranasal inoculation may be an alternative approach against pneumococci. In this study, BALB/c mice were intranasally inoculated with recombinant IL‐17F (rIL‐17F) prior to S. pneumoniae (American Type Culture Collection 6303, serotype 3) infection. As compared with the control group, numbers of total leukocyte, neutrophil, and macrophage in lungs were significantly increased in mice inoculated with rIL‐17F. The levels of macrophage inflammatory protein 1α (MIP‐1α), MIP‐2β, and interferon γ were significantly increased in bronchoalveolar lavage fluid and culture supernatant of splenocytes from mice inoculated with rIL‐17F. rIL‐17F inoculation also significantly elevated β‐defensin‐2 expression in lung tissues. Furthermore, compared with S. pneumoniae infection group, rIL‐17F inoculation prior to infection significantly reduced S. pneumoniae colonization in lungs. These findings demonstrated that rIL‐17F intranasal inoculation strengthened host defense against pneumococci, which may be developed to prevent pneumococcal infection. |
| abstract_unstemmed |
Interleukin‐17F (IL‐17F) is an important member of IL‐17 cytokine family, which plays important roles in host defense against microbial infections. Streptococcus pneumoniae is a common pathogen associated with several invasive and noninvasive pneumococcal diseases, and mucosal immune response plays crucial roles in defenses against pneumococcal infection. Thus, intranasal inoculation may be an alternative approach against pneumococci. In this study, BALB/c mice were intranasally inoculated with recombinant IL‐17F (rIL‐17F) prior to S. pneumoniae (American Type Culture Collection 6303, serotype 3) infection. As compared with the control group, numbers of total leukocyte, neutrophil, and macrophage in lungs were significantly increased in mice inoculated with rIL‐17F. The levels of macrophage inflammatory protein 1α (MIP‐1α), MIP‐2β, and interferon γ were significantly increased in bronchoalveolar lavage fluid and culture supernatant of splenocytes from mice inoculated with rIL‐17F. rIL‐17F inoculation also significantly elevated β‐defensin‐2 expression in lung tissues. Furthermore, compared with S. pneumoniae infection group, rIL‐17F inoculation prior to infection significantly reduced S. pneumoniae colonization in lungs. These findings demonstrated that rIL‐17F intranasal inoculation strengthened host defense against pneumococci, which may be developed to prevent pneumococcal infection. |
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Effects of recombinant IL‐17F intranasal inoculation against Streptococcus pneumoniae infection in a murine model |
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