Itaconic Acid: The Surprising Role of an Industrial Compound as a Mammalian Antimicrobial Metabolite
Itaconic acid is well known as a precursor for polymer synthesis and has been involved in industrial processes for decades. In a recent surprising discovery, itaconic acid was found to play a role as an immune-supportive metabolite in mammalian immune cells, where it is synthesized as an antimicrobi...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Cordes, Thekla [verfasserIn] |
|---|
| Format: |
Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Übergeordnetes Werk: |
Enthalten in: Annual review of nutrition - Palo Alto, Calif. : Annual Reviews Inc., 1981, 35(2015), 1, Seite 451-473 |
|---|---|
| Übergeordnetes Werk: |
volume:35 ; year:2015 ; number:1 ; pages:451-473 |
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|---|
| DOI / URN: |
10.1146/annurev-nutr-071714-034243 |
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OLC1968628452 |
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| 520 | |a Itaconic acid is well known as a precursor for polymer synthesis and has been involved in industrial processes for decades. In a recent surprising discovery, itaconic acid was found to play a role as an immune-supportive metabolite in mammalian immune cells, where it is synthesized as an antimicrobial compound from the citric acid cycle intermediate cis-aconitic acid. Although the immune-responsive gene 1 protein (IRG1) has been associated to immune response without a mechanistic function, the critical link to itaconic acid production through an enzymatic function of this protein was only recently revealed. In this review, we highlight the history of itaconic acid as an industrial and antimicrobial compound, starting with its biotechnological synthesis and ending with its antimicrobial function in mammalian immune cells. | ||
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10.1146/annurev-nutr-071714-034243 doi PQ20160617 (DE-627)OLC1968628452 (DE-599)GBVOLC1968628452 (PRQ)c1345-a6276deedbaf9f32b413195c56c37d9cad654728b077758a6d83f0890a7d6c680 (KEY)0105894020150000035000100451itaconicacidthesurprisingroleofanindustrialcompoun DE-627 ger DE-627 rakwb eng 630 640 610 DNB 44.21 bkl Cordes, Thekla verfasserin aut Itaconic Acid: The Surprising Role of an Industrial Compound as a Mammalian Antimicrobial Metabolite 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Itaconic acid is well known as a precursor for polymer synthesis and has been involved in industrial processes for decades. In a recent surprising discovery, itaconic acid was found to play a role as an immune-supportive metabolite in mammalian immune cells, where it is synthesized as an antimicrobial compound from the citric acid cycle intermediate cis-aconitic acid. Although the immune-responsive gene 1 protein (IRG1) has been associated to immune response without a mechanistic function, the critical link to itaconic acid production through an enzymatic function of this protein was only recently revealed. In this review, we highlight the history of itaconic acid as an industrial and antimicrobial compound, starting with its biotechnological synthesis and ending with its antimicrobial function in mammalian immune cells. Michelucci, Alessandro oth Hiller, Karsten oth Enthalten in Annual review of nutrition Palo Alto, Calif. : Annual Reviews Inc., 1981 35(2015), 1, Seite 451-473 (DE-627)129961817 (DE-600)406980-8 (DE-576)015529940 0199-9885 nnns volume:35 year:2015 number:1 pages:451-473 http://dx.doi.org/10.1146/annurev-nutr-071714-034243 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25974697 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_252 GBV_ILN_4012 44.21 AVZ AR 35 2015 1 451-473 |
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Itaconic Acid: The Surprising Role of an Industrial Compound as a Mammalian Antimicrobial Metabolite |
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Itaconic acid is well known as a precursor for polymer synthesis and has been involved in industrial processes for decades. In a recent surprising discovery, itaconic acid was found to play a role as an immune-supportive metabolite in mammalian immune cells, where it is synthesized as an antimicrobial compound from the citric acid cycle intermediate cis-aconitic acid. Although the immune-responsive gene 1 protein (IRG1) has been associated to immune response without a mechanistic function, the critical link to itaconic acid production through an enzymatic function of this protein was only recently revealed. In this review, we highlight the history of itaconic acid as an industrial and antimicrobial compound, starting with its biotechnological synthesis and ending with its antimicrobial function in mammalian immune cells. |
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Itaconic acid is well known as a precursor for polymer synthesis and has been involved in industrial processes for decades. In a recent surprising discovery, itaconic acid was found to play a role as an immune-supportive metabolite in mammalian immune cells, where it is synthesized as an antimicrobial compound from the citric acid cycle intermediate cis-aconitic acid. Although the immune-responsive gene 1 protein (IRG1) has been associated to immune response without a mechanistic function, the critical link to itaconic acid production through an enzymatic function of this protein was only recently revealed. In this review, we highlight the history of itaconic acid as an industrial and antimicrobial compound, starting with its biotechnological synthesis and ending with its antimicrobial function in mammalian immune cells. |
| abstract_unstemmed |
Itaconic acid is well known as a precursor for polymer synthesis and has been involved in industrial processes for decades. In a recent surprising discovery, itaconic acid was found to play a role as an immune-supportive metabolite in mammalian immune cells, where it is synthesized as an antimicrobial compound from the citric acid cycle intermediate cis-aconitic acid. Although the immune-responsive gene 1 protein (IRG1) has been associated to immune response without a mechanistic function, the critical link to itaconic acid production through an enzymatic function of this protein was only recently revealed. In this review, we highlight the history of itaconic acid as an industrial and antimicrobial compound, starting with its biotechnological synthesis and ending with its antimicrobial function in mammalian immune cells. |
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| title_short |
Itaconic Acid: The Surprising Role of an Industrial Compound as a Mammalian Antimicrobial Metabolite |
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http://dx.doi.org/10.1146/annurev-nutr-071714-034243 http://www.ncbi.nlm.nih.gov/pubmed/25974697 |
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Michelucci, Alessandro Hiller, Karsten |
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10.1146/annurev-nutr-071714-034243 |
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2024-07-04T03:49:51.750Z |
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