Low molecular weight heparin mediating targeting of lymph node metastasis based on nanoliposome and enzyme-substrate interaction
The aim of our study is to develop a new function of low molecular weight heparin (LMWHEP) for targeting tumor metastatic lymph node based on LMWHEP-modified nanoliposome and LMWHEP-heparanase (HPA) interaction (LMWHEP-HPA). At First, LMWHEP-modified nanoliposomes (LMWHEP-LPs) were prepared by the e...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ye, Tiantian [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Rechteinformationen: |
Nutzungsrecht: Copyright © 2015 Elsevier Ltd. All rights reserved. |
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| Schlagwörter: |
Heparin, Low-Molecular-Weight - metabolism Heparin, Low-Molecular-Weight - pharmacology Heparin, Low-Molecular-Weight - administration & dosage |
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| Übergeordnetes Werk: |
Enthalten in: Carbohydrate polymers - Barking, Essex : Applied Science Publ., 1981, 122(2015), Seite 26-38 |
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| Übergeordnetes Werk: |
volume:122 ; year:2015 ; pages:26-38 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.carbpol.2014.12.061 |
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| 520 | |a The aim of our study is to develop a new function of low molecular weight heparin (LMWHEP) for targeting tumor metastatic lymph node based on LMWHEP-modified nanoliposome and LMWHEP-heparanase (HPA) interaction (LMWHEP-HPA). At First, LMWHEP-modified nanoliposomes (LMWHEP-LPs) were prepared by the electrostatic attraction and the physiochemical properties were evaluated. Then the effects of LMWHEP-HPA on the stability and drug release were investigated. In addition, the cellular uptake of LMWHEP-LPs was studied by using Hela, MCF-7, L929 and RAW264.7 cells. Finally, the targeting ability as well as the tissue distribution was examined in the mice model bearing Hela tumor lymph node metastasis. LMWHEP-LPs prepared had suitable physicochemical properties. The effect results of LMWHEP-HPA showed that LMWHEP coated on the surface of nanoliposome could be degraded by HPA. Compared with the unmodified-nanoliposome, the LMWHEP modification could improve the cellular uptake and increase the targeting ability to the metastatic lymph nodes according to LMWHEP-HPA. This study demonstrates LMWHEP is a highly promising polymer material for the targeting of tumor lymph node metastasis. | ||
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| 650 | 4 | |a Heparin, Low-Molecular-Weight - metabolism | |
| 650 | 4 | |a Heparin, Low-Molecular-Weight - pharmacology | |
| 650 | 4 | |a Glucuronidase - metabolism | |
| 650 | 4 | |a Lymph Nodes - blood supply | |
| 650 | 4 | |a Lymph Nodes - pathology | |
| 650 | 4 | |a Heparin, Low-Molecular-Weight - administration & dosage | |
| 650 | 4 | |a Lymph Nodes - drug effects | |
| 650 | 4 | |a Heparin, Low-Molecular-Weight - pharmacokinetics | |
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| 700 | 1 | |a Jiang, Xuewei |4 oth | |
| 700 | 1 | |a Li, Jing |4 oth | |
| 700 | 1 | |a Yang, Rui |4 oth | |
| 700 | 1 | |a Mao, Yuling |4 oth | |
| 700 | 1 | |a Li, Kai |4 oth | |
| 700 | 1 | |a Li, Liang |4 oth | |
| 700 | 1 | |a Chen, Fen |4 oth | |
| 700 | 1 | |a Yao, Jianhua |4 oth | |
| 700 | 1 | |a Wu, Yingliang |4 oth | |
| 700 | 1 | |a Yang, Xinggang |4 oth | |
| 700 | 1 | |a Wang, Shujun |4 oth | |
| 700 | 1 | |a Pan, Weisan |4 oth | |
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10.1016/j.carbpol.2014.12.061 doi PQ20160617 (DE-627)OLC1968866078 (DE-599)GBVOLC1968866078 (PRQ)c1295-bc0b6e2573e611cd17386c110dfeac472c8629d43fe023df29c08bae99a74bd90 (KEY)0110347420150000122000000026lowmolecularweightheparinmediatingtargetingoflymph DE-627 ger DE-627 rakwb eng 540 660 DNB 58.34 bkl 49.25 bkl Ye, Tiantian verfasserin aut Low molecular weight heparin mediating targeting of lymph node metastasis based on nanoliposome and enzyme-substrate interaction 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The aim of our study is to develop a new function of low molecular weight heparin (LMWHEP) for targeting tumor metastatic lymph node based on LMWHEP-modified nanoliposome and LMWHEP-heparanase (HPA) interaction (LMWHEP-HPA). At First, LMWHEP-modified nanoliposomes (LMWHEP-LPs) were prepared by the electrostatic attraction and the physiochemical properties were evaluated. Then the effects of LMWHEP-HPA on the stability and drug release were investigated. In addition, the cellular uptake of LMWHEP-LPs was studied by using Hela, MCF-7, L929 and RAW264.7 cells. Finally, the targeting ability as well as the tissue distribution was examined in the mice model bearing Hela tumor lymph node metastasis. LMWHEP-LPs prepared had suitable physicochemical properties. The effect results of LMWHEP-HPA showed that LMWHEP coated on the surface of nanoliposome could be degraded by HPA. Compared with the unmodified-nanoliposome, the LMWHEP modification could improve the cellular uptake and increase the targeting ability to the metastatic lymph nodes according to LMWHEP-HPA. This study demonstrates LMWHEP is a highly promising polymer material for the targeting of tumor lymph node metastasis. Nutzungsrecht: Copyright © 2015 Elsevier Ltd. All rights reserved. Heparin, Low-Molecular-Weight - metabolism Heparin, Low-Molecular-Weight - pharmacology Glucuronidase - metabolism Lymph Nodes - blood supply Lymph Nodes - pathology Heparin, Low-Molecular-Weight - administration & dosage Lymph Nodes - drug effects Heparin, Low-Molecular-Weight - pharmacokinetics Water - chemistry Jiang, Xuewei oth Li, Jing oth Yang, Rui oth Mao, Yuling oth Li, Kai oth Li, Liang oth Chen, Fen oth Yao, Jianhua oth Wu, Yingliang oth Yang, Xinggang oth Wang, Shujun oth Pan, Weisan oth Enthalten in Carbohydrate polymers Barking, Essex : Applied Science Publ., 1981 122(2015), Seite 26-38 (DE-627)130549746 (DE-600)782631-X (DE-576)481341323 0144-8617 nnns volume:122 year:2015 pages:26-38 http://dx.doi.org/10.1016/j.carbpol.2014.12.061 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25817639 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 GBV_ILN_4012 58.34 AVZ 49.25 AVZ AR 122 2015 26-38 |
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10.1016/j.carbpol.2014.12.061 doi PQ20160617 (DE-627)OLC1968866078 (DE-599)GBVOLC1968866078 (PRQ)c1295-bc0b6e2573e611cd17386c110dfeac472c8629d43fe023df29c08bae99a74bd90 (KEY)0110347420150000122000000026lowmolecularweightheparinmediatingtargetingoflymph DE-627 ger DE-627 rakwb eng 540 660 DNB 58.34 bkl 49.25 bkl Ye, Tiantian verfasserin aut Low molecular weight heparin mediating targeting of lymph node metastasis based on nanoliposome and enzyme-substrate interaction 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The aim of our study is to develop a new function of low molecular weight heparin (LMWHEP) for targeting tumor metastatic lymph node based on LMWHEP-modified nanoliposome and LMWHEP-heparanase (HPA) interaction (LMWHEP-HPA). At First, LMWHEP-modified nanoliposomes (LMWHEP-LPs) were prepared by the electrostatic attraction and the physiochemical properties were evaluated. Then the effects of LMWHEP-HPA on the stability and drug release were investigated. In addition, the cellular uptake of LMWHEP-LPs was studied by using Hela, MCF-7, L929 and RAW264.7 cells. Finally, the targeting ability as well as the tissue distribution was examined in the mice model bearing Hela tumor lymph node metastasis. LMWHEP-LPs prepared had suitable physicochemical properties. The effect results of LMWHEP-HPA showed that LMWHEP coated on the surface of nanoliposome could be degraded by HPA. Compared with the unmodified-nanoliposome, the LMWHEP modification could improve the cellular uptake and increase the targeting ability to the metastatic lymph nodes according to LMWHEP-HPA. This study demonstrates LMWHEP is a highly promising polymer material for the targeting of tumor lymph node metastasis. Nutzungsrecht: Copyright © 2015 Elsevier Ltd. All rights reserved. Heparin, Low-Molecular-Weight - metabolism Heparin, Low-Molecular-Weight - pharmacology Glucuronidase - metabolism Lymph Nodes - blood supply Lymph Nodes - pathology Heparin, Low-Molecular-Weight - administration & dosage Lymph Nodes - drug effects Heparin, Low-Molecular-Weight - pharmacokinetics Water - chemistry Jiang, Xuewei oth Li, Jing oth Yang, Rui oth Mao, Yuling oth Li, Kai oth Li, Liang oth Chen, Fen oth Yao, Jianhua oth Wu, Yingliang oth Yang, Xinggang oth Wang, Shujun oth Pan, Weisan oth Enthalten in Carbohydrate polymers Barking, Essex : Applied Science Publ., 1981 122(2015), Seite 26-38 (DE-627)130549746 (DE-600)782631-X (DE-576)481341323 0144-8617 nnns volume:122 year:2015 pages:26-38 http://dx.doi.org/10.1016/j.carbpol.2014.12.061 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25817639 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 GBV_ILN_4012 58.34 AVZ 49.25 AVZ AR 122 2015 26-38 |
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10.1016/j.carbpol.2014.12.061 doi PQ20160617 (DE-627)OLC1968866078 (DE-599)GBVOLC1968866078 (PRQ)c1295-bc0b6e2573e611cd17386c110dfeac472c8629d43fe023df29c08bae99a74bd90 (KEY)0110347420150000122000000026lowmolecularweightheparinmediatingtargetingoflymph DE-627 ger DE-627 rakwb eng 540 660 DNB 58.34 bkl 49.25 bkl Ye, Tiantian verfasserin aut Low molecular weight heparin mediating targeting of lymph node metastasis based on nanoliposome and enzyme-substrate interaction 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The aim of our study is to develop a new function of low molecular weight heparin (LMWHEP) for targeting tumor metastatic lymph node based on LMWHEP-modified nanoliposome and LMWHEP-heparanase (HPA) interaction (LMWHEP-HPA). At First, LMWHEP-modified nanoliposomes (LMWHEP-LPs) were prepared by the electrostatic attraction and the physiochemical properties were evaluated. Then the effects of LMWHEP-HPA on the stability and drug release were investigated. In addition, the cellular uptake of LMWHEP-LPs was studied by using Hela, MCF-7, L929 and RAW264.7 cells. Finally, the targeting ability as well as the tissue distribution was examined in the mice model bearing Hela tumor lymph node metastasis. LMWHEP-LPs prepared had suitable physicochemical properties. The effect results of LMWHEP-HPA showed that LMWHEP coated on the surface of nanoliposome could be degraded by HPA. Compared with the unmodified-nanoliposome, the LMWHEP modification could improve the cellular uptake and increase the targeting ability to the metastatic lymph nodes according to LMWHEP-HPA. This study demonstrates LMWHEP is a highly promising polymer material for the targeting of tumor lymph node metastasis. Nutzungsrecht: Copyright © 2015 Elsevier Ltd. All rights reserved. Heparin, Low-Molecular-Weight - metabolism Heparin, Low-Molecular-Weight - pharmacology Glucuronidase - metabolism Lymph Nodes - blood supply Lymph Nodes - pathology Heparin, Low-Molecular-Weight - administration & dosage Lymph Nodes - drug effects Heparin, Low-Molecular-Weight - pharmacokinetics Water - chemistry Jiang, Xuewei oth Li, Jing oth Yang, Rui oth Mao, Yuling oth Li, Kai oth Li, Liang oth Chen, Fen oth Yao, Jianhua oth Wu, Yingliang oth Yang, Xinggang oth Wang, Shujun oth Pan, Weisan oth Enthalten in Carbohydrate polymers Barking, Essex : Applied Science Publ., 1981 122(2015), Seite 26-38 (DE-627)130549746 (DE-600)782631-X (DE-576)481341323 0144-8617 nnns volume:122 year:2015 pages:26-38 http://dx.doi.org/10.1016/j.carbpol.2014.12.061 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25817639 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 GBV_ILN_4012 58.34 AVZ 49.25 AVZ AR 122 2015 26-38 |
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10.1016/j.carbpol.2014.12.061 doi PQ20160617 (DE-627)OLC1968866078 (DE-599)GBVOLC1968866078 (PRQ)c1295-bc0b6e2573e611cd17386c110dfeac472c8629d43fe023df29c08bae99a74bd90 (KEY)0110347420150000122000000026lowmolecularweightheparinmediatingtargetingoflymph DE-627 ger DE-627 rakwb eng 540 660 DNB 58.34 bkl 49.25 bkl Ye, Tiantian verfasserin aut Low molecular weight heparin mediating targeting of lymph node metastasis based on nanoliposome and enzyme-substrate interaction 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The aim of our study is to develop a new function of low molecular weight heparin (LMWHEP) for targeting tumor metastatic lymph node based on LMWHEP-modified nanoliposome and LMWHEP-heparanase (HPA) interaction (LMWHEP-HPA). At First, LMWHEP-modified nanoliposomes (LMWHEP-LPs) were prepared by the electrostatic attraction and the physiochemical properties were evaluated. Then the effects of LMWHEP-HPA on the stability and drug release were investigated. In addition, the cellular uptake of LMWHEP-LPs was studied by using Hela, MCF-7, L929 and RAW264.7 cells. Finally, the targeting ability as well as the tissue distribution was examined in the mice model bearing Hela tumor lymph node metastasis. LMWHEP-LPs prepared had suitable physicochemical properties. The effect results of LMWHEP-HPA showed that LMWHEP coated on the surface of nanoliposome could be degraded by HPA. Compared with the unmodified-nanoliposome, the LMWHEP modification could improve the cellular uptake and increase the targeting ability to the metastatic lymph nodes according to LMWHEP-HPA. This study demonstrates LMWHEP is a highly promising polymer material for the targeting of tumor lymph node metastasis. Nutzungsrecht: Copyright © 2015 Elsevier Ltd. All rights reserved. Heparin, Low-Molecular-Weight - metabolism Heparin, Low-Molecular-Weight - pharmacology Glucuronidase - metabolism Lymph Nodes - blood supply Lymph Nodes - pathology Heparin, Low-Molecular-Weight - administration & dosage Lymph Nodes - drug effects Heparin, Low-Molecular-Weight - pharmacokinetics Water - chemistry Jiang, Xuewei oth Li, Jing oth Yang, Rui oth Mao, Yuling oth Li, Kai oth Li, Liang oth Chen, Fen oth Yao, Jianhua oth Wu, Yingliang oth Yang, Xinggang oth Wang, Shujun oth Pan, Weisan oth Enthalten in Carbohydrate polymers Barking, Essex : Applied Science Publ., 1981 122(2015), Seite 26-38 (DE-627)130549746 (DE-600)782631-X (DE-576)481341323 0144-8617 nnns volume:122 year:2015 pages:26-38 http://dx.doi.org/10.1016/j.carbpol.2014.12.061 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25817639 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 GBV_ILN_4012 58.34 AVZ 49.25 AVZ AR 122 2015 26-38 |
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10.1016/j.carbpol.2014.12.061 doi PQ20160617 (DE-627)OLC1968866078 (DE-599)GBVOLC1968866078 (PRQ)c1295-bc0b6e2573e611cd17386c110dfeac472c8629d43fe023df29c08bae99a74bd90 (KEY)0110347420150000122000000026lowmolecularweightheparinmediatingtargetingoflymph DE-627 ger DE-627 rakwb eng 540 660 DNB 58.34 bkl 49.25 bkl Ye, Tiantian verfasserin aut Low molecular weight heparin mediating targeting of lymph node metastasis based on nanoliposome and enzyme-substrate interaction 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The aim of our study is to develop a new function of low molecular weight heparin (LMWHEP) for targeting tumor metastatic lymph node based on LMWHEP-modified nanoliposome and LMWHEP-heparanase (HPA) interaction (LMWHEP-HPA). At First, LMWHEP-modified nanoliposomes (LMWHEP-LPs) were prepared by the electrostatic attraction and the physiochemical properties were evaluated. Then the effects of LMWHEP-HPA on the stability and drug release were investigated. In addition, the cellular uptake of LMWHEP-LPs was studied by using Hela, MCF-7, L929 and RAW264.7 cells. Finally, the targeting ability as well as the tissue distribution was examined in the mice model bearing Hela tumor lymph node metastasis. LMWHEP-LPs prepared had suitable physicochemical properties. The effect results of LMWHEP-HPA showed that LMWHEP coated on the surface of nanoliposome could be degraded by HPA. Compared with the unmodified-nanoliposome, the LMWHEP modification could improve the cellular uptake and increase the targeting ability to the metastatic lymph nodes according to LMWHEP-HPA. This study demonstrates LMWHEP is a highly promising polymer material for the targeting of tumor lymph node metastasis. Nutzungsrecht: Copyright © 2015 Elsevier Ltd. All rights reserved. Heparin, Low-Molecular-Weight - metabolism Heparin, Low-Molecular-Weight - pharmacology Glucuronidase - metabolism Lymph Nodes - blood supply Lymph Nodes - pathology Heparin, Low-Molecular-Weight - administration & dosage Lymph Nodes - drug effects Heparin, Low-Molecular-Weight - pharmacokinetics Water - chemistry Jiang, Xuewei oth Li, Jing oth Yang, Rui oth Mao, Yuling oth Li, Kai oth Li, Liang oth Chen, Fen oth Yao, Jianhua oth Wu, Yingliang oth Yang, Xinggang oth Wang, Shujun oth Pan, Weisan oth Enthalten in Carbohydrate polymers Barking, Essex : Applied Science Publ., 1981 122(2015), Seite 26-38 (DE-627)130549746 (DE-600)782631-X (DE-576)481341323 0144-8617 nnns volume:122 year:2015 pages:26-38 http://dx.doi.org/10.1016/j.carbpol.2014.12.061 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25817639 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE GBV_ILN_70 GBV_ILN_4012 58.34 AVZ 49.25 AVZ AR 122 2015 26-38 |
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At First, LMWHEP-modified nanoliposomes (LMWHEP-LPs) were prepared by the electrostatic attraction and the physiochemical properties were evaluated. Then the effects of LMWHEP-HPA on the stability and drug release were investigated. In addition, the cellular uptake of LMWHEP-LPs was studied by using Hela, MCF-7, L929 and RAW264.7 cells. Finally, the targeting ability as well as the tissue distribution was examined in the mice model bearing Hela tumor lymph node metastasis. LMWHEP-LPs prepared had suitable physicochemical properties. The effect results of LMWHEP-HPA showed that LMWHEP coated on the surface of nanoliposome could be degraded by HPA. Compared with the unmodified-nanoliposome, the LMWHEP modification could improve the cellular uptake and increase the targeting ability to the metastatic lymph nodes according to LMWHEP-HPA. 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Ye, Tiantian ddc 540 bkl 58.34 bkl 49.25 misc Heparin, Low-Molecular-Weight - metabolism misc Heparin, Low-Molecular-Weight - pharmacology misc Glucuronidase - metabolism misc Lymph Nodes - blood supply misc Lymph Nodes - pathology misc Heparin, Low-Molecular-Weight - administration & dosage misc Lymph Nodes - drug effects misc Heparin, Low-Molecular-Weight - pharmacokinetics misc Water - chemistry Low molecular weight heparin mediating targeting of lymph node metastasis based on nanoliposome and enzyme-substrate interaction |
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540 660 DNB 58.34 bkl 49.25 bkl Low molecular weight heparin mediating targeting of lymph node metastasis based on nanoliposome and enzyme-substrate interaction Heparin, Low-Molecular-Weight - metabolism Heparin, Low-Molecular-Weight - pharmacology Glucuronidase - metabolism Lymph Nodes - blood supply Lymph Nodes - pathology Heparin, Low-Molecular-Weight - administration & dosage Lymph Nodes - drug effects Heparin, Low-Molecular-Weight - pharmacokinetics Water - chemistry |
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Low molecular weight heparin mediating targeting of lymph node metastasis based on nanoliposome and enzyme-substrate interaction |
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low molecular weight heparin mediating targeting of lymph node metastasis based on nanoliposome and enzyme-substrate interaction |
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Low molecular weight heparin mediating targeting of lymph node metastasis based on nanoliposome and enzyme-substrate interaction |
| abstract |
The aim of our study is to develop a new function of low molecular weight heparin (LMWHEP) for targeting tumor metastatic lymph node based on LMWHEP-modified nanoliposome and LMWHEP-heparanase (HPA) interaction (LMWHEP-HPA). At First, LMWHEP-modified nanoliposomes (LMWHEP-LPs) were prepared by the electrostatic attraction and the physiochemical properties were evaluated. Then the effects of LMWHEP-HPA on the stability and drug release were investigated. In addition, the cellular uptake of LMWHEP-LPs was studied by using Hela, MCF-7, L929 and RAW264.7 cells. Finally, the targeting ability as well as the tissue distribution was examined in the mice model bearing Hela tumor lymph node metastasis. LMWHEP-LPs prepared had suitable physicochemical properties. The effect results of LMWHEP-HPA showed that LMWHEP coated on the surface of nanoliposome could be degraded by HPA. Compared with the unmodified-nanoliposome, the LMWHEP modification could improve the cellular uptake and increase the targeting ability to the metastatic lymph nodes according to LMWHEP-HPA. This study demonstrates LMWHEP is a highly promising polymer material for the targeting of tumor lymph node metastasis. |
| abstractGer |
The aim of our study is to develop a new function of low molecular weight heparin (LMWHEP) for targeting tumor metastatic lymph node based on LMWHEP-modified nanoliposome and LMWHEP-heparanase (HPA) interaction (LMWHEP-HPA). At First, LMWHEP-modified nanoliposomes (LMWHEP-LPs) were prepared by the electrostatic attraction and the physiochemical properties were evaluated. Then the effects of LMWHEP-HPA on the stability and drug release were investigated. In addition, the cellular uptake of LMWHEP-LPs was studied by using Hela, MCF-7, L929 and RAW264.7 cells. Finally, the targeting ability as well as the tissue distribution was examined in the mice model bearing Hela tumor lymph node metastasis. LMWHEP-LPs prepared had suitable physicochemical properties. The effect results of LMWHEP-HPA showed that LMWHEP coated on the surface of nanoliposome could be degraded by HPA. Compared with the unmodified-nanoliposome, the LMWHEP modification could improve the cellular uptake and increase the targeting ability to the metastatic lymph nodes according to LMWHEP-HPA. This study demonstrates LMWHEP is a highly promising polymer material for the targeting of tumor lymph node metastasis. |
| abstract_unstemmed |
The aim of our study is to develop a new function of low molecular weight heparin (LMWHEP) for targeting tumor metastatic lymph node based on LMWHEP-modified nanoliposome and LMWHEP-heparanase (HPA) interaction (LMWHEP-HPA). At First, LMWHEP-modified nanoliposomes (LMWHEP-LPs) were prepared by the electrostatic attraction and the physiochemical properties were evaluated. Then the effects of LMWHEP-HPA on the stability and drug release were investigated. In addition, the cellular uptake of LMWHEP-LPs was studied by using Hela, MCF-7, L929 and RAW264.7 cells. Finally, the targeting ability as well as the tissue distribution was examined in the mice model bearing Hela tumor lymph node metastasis. LMWHEP-LPs prepared had suitable physicochemical properties. The effect results of LMWHEP-HPA showed that LMWHEP coated on the surface of nanoliposome could be degraded by HPA. Compared with the unmodified-nanoliposome, the LMWHEP modification could improve the cellular uptake and increase the targeting ability to the metastatic lymph nodes according to LMWHEP-HPA. This study demonstrates LMWHEP is a highly promising polymer material for the targeting of tumor lymph node metastasis. |
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Low molecular weight heparin mediating targeting of lymph node metastasis based on nanoliposome and enzyme-substrate interaction |
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http://dx.doi.org/10.1016/j.carbpol.2014.12.061 http://www.ncbi.nlm.nih.gov/pubmed/25817639 |
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Jiang, Xuewei Li, Jing Yang, Rui Mao, Yuling Li, Kai Li, Liang Chen, Fen Yao, Jianhua Wu, Yingliang Yang, Xinggang Wang, Shujun Pan, Weisan |
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