The dark side of sunlight and melanoma

Skin cancer is the most prevalent form of cancer, with a lifetime risk of 1 in 5 for Americans . Most skin cancers can be attributed to C[arrow right]T and CC[arrow right]TT mutations in DNA resulting from cyclobutane pyrimidine dimers (CPDs) produced by the direct absorption of UVB light (290 to 32...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	John-Stephen Taylor [verfasserIn]

Format:	Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Skin cancer Melanoma Sun

Übergeordnetes Werk:	Enthalten in: Science - Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883, 347(2015), 6224, Seite 824-824
Übergeordnetes Werk:	volume:347 ; year:2015 ; number:6224 ; pages:824-824

Links:	Volltext Link aufrufen

DOI / URN:	10.1126/science.aaa6578

Katalog-ID:	OLC196951132X

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publishDate	2015
allfields	10.1126/science.aaa6578 doi PQ20160211 (DE-627)OLC196951132X (DE-599)GBVOLC196951132X (PRQ)c1560-d5f970947de596cd76b05e074a7a47ced847e3452108b1ffce03dcea8ca9f2aa0 (KEY)0063888920150000347622400824darksideofsunlightandmelanoma DE-627 ger DE-627 rakwb eng 500 DNB LING fid John-Stephen Taylor verfasserin aut The dark side of sunlight and melanoma 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Skin cancer is the most prevalent form of cancer, with a lifetime risk of 1 in 5 for Americans . Most skin cancers can be attributed to C[arrow right]T and CC[arrow right]TT mutations in DNA resulting from cyclobutane pyrimidine dimers (CPDs) produced by the direct absorption of UVB light (290 to 320 nm) present in sunlight . The most generally accepted mechanism for the formation of these mutations is that Cs or 5-methyl-Cs in the CPDs rapidly deaminate to Us or Ts, which are then replicated in an error-free manner. One might expect that photodamage would cease once out of the Sun, but Premi et al., on page 842 of this issue, show that this is not the case in melanocytes . A substantial fraction of UV damage to DNA in these cells may be occurring in the dark, by a novel pathway with important implications for melanoma formation. Skin cancer Melanoma Sun Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 347(2015), 6224, Seite 824-824 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:347 year:2015 number:6224 pages:824-824 http://dx.doi.org/10.1126/science.aaa6578 Volltext http://search.proquest.com/docview/1656314103 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2185 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 347 2015 6224 824-824
spelling	10.1126/science.aaa6578 doi PQ20160211 (DE-627)OLC196951132X (DE-599)GBVOLC196951132X (PRQ)c1560-d5f970947de596cd76b05e074a7a47ced847e3452108b1ffce03dcea8ca9f2aa0 (KEY)0063888920150000347622400824darksideofsunlightandmelanoma DE-627 ger DE-627 rakwb eng 500 DNB LING fid John-Stephen Taylor verfasserin aut The dark side of sunlight and melanoma 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Skin cancer is the most prevalent form of cancer, with a lifetime risk of 1 in 5 for Americans . Most skin cancers can be attributed to C[arrow right]T and CC[arrow right]TT mutations in DNA resulting from cyclobutane pyrimidine dimers (CPDs) produced by the direct absorption of UVB light (290 to 320 nm) present in sunlight . The most generally accepted mechanism for the formation of these mutations is that Cs or 5-methyl-Cs in the CPDs rapidly deaminate to Us or Ts, which are then replicated in an error-free manner. One might expect that photodamage would cease once out of the Sun, but Premi et al., on page 842 of this issue, show that this is not the case in melanocytes . A substantial fraction of UV damage to DNA in these cells may be occurring in the dark, by a novel pathway with important implications for melanoma formation. Skin cancer Melanoma Sun Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 347(2015), 6224, Seite 824-824 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:347 year:2015 number:6224 pages:824-824 http://dx.doi.org/10.1126/science.aaa6578 Volltext http://search.proquest.com/docview/1656314103 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2185 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 347 2015 6224 824-824
allfields_unstemmed	10.1126/science.aaa6578 doi PQ20160211 (DE-627)OLC196951132X (DE-599)GBVOLC196951132X (PRQ)c1560-d5f970947de596cd76b05e074a7a47ced847e3452108b1ffce03dcea8ca9f2aa0 (KEY)0063888920150000347622400824darksideofsunlightandmelanoma DE-627 ger DE-627 rakwb eng 500 DNB LING fid John-Stephen Taylor verfasserin aut The dark side of sunlight and melanoma 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Skin cancer is the most prevalent form of cancer, with a lifetime risk of 1 in 5 for Americans . Most skin cancers can be attributed to C[arrow right]T and CC[arrow right]TT mutations in DNA resulting from cyclobutane pyrimidine dimers (CPDs) produced by the direct absorption of UVB light (290 to 320 nm) present in sunlight . The most generally accepted mechanism for the formation of these mutations is that Cs or 5-methyl-Cs in the CPDs rapidly deaminate to Us or Ts, which are then replicated in an error-free manner. One might expect that photodamage would cease once out of the Sun, but Premi et al., on page 842 of this issue, show that this is not the case in melanocytes . A substantial fraction of UV damage to DNA in these cells may be occurring in the dark, by a novel pathway with important implications for melanoma formation. Skin cancer Melanoma Sun Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 347(2015), 6224, Seite 824-824 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:347 year:2015 number:6224 pages:824-824 http://dx.doi.org/10.1126/science.aaa6578 Volltext http://search.proquest.com/docview/1656314103 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2185 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 347 2015 6224 824-824
allfieldsGer	10.1126/science.aaa6578 doi PQ20160211 (DE-627)OLC196951132X (DE-599)GBVOLC196951132X (PRQ)c1560-d5f970947de596cd76b05e074a7a47ced847e3452108b1ffce03dcea8ca9f2aa0 (KEY)0063888920150000347622400824darksideofsunlightandmelanoma DE-627 ger DE-627 rakwb eng 500 DNB LING fid John-Stephen Taylor verfasserin aut The dark side of sunlight and melanoma 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Skin cancer is the most prevalent form of cancer, with a lifetime risk of 1 in 5 for Americans . Most skin cancers can be attributed to C[arrow right]T and CC[arrow right]TT mutations in DNA resulting from cyclobutane pyrimidine dimers (CPDs) produced by the direct absorption of UVB light (290 to 320 nm) present in sunlight . The most generally accepted mechanism for the formation of these mutations is that Cs or 5-methyl-Cs in the CPDs rapidly deaminate to Us or Ts, which are then replicated in an error-free manner. One might expect that photodamage would cease once out of the Sun, but Premi et al., on page 842 of this issue, show that this is not the case in melanocytes . A substantial fraction of UV damage to DNA in these cells may be occurring in the dark, by a novel pathway with important implications for melanoma formation. Skin cancer Melanoma Sun Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 347(2015), 6224, Seite 824-824 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:347 year:2015 number:6224 pages:824-824 http://dx.doi.org/10.1126/science.aaa6578 Volltext http://search.proquest.com/docview/1656314103 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2185 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 347 2015 6224 824-824
allfieldsSound	10.1126/science.aaa6578 doi PQ20160211 (DE-627)OLC196951132X (DE-599)GBVOLC196951132X (PRQ)c1560-d5f970947de596cd76b05e074a7a47ced847e3452108b1ffce03dcea8ca9f2aa0 (KEY)0063888920150000347622400824darksideofsunlightandmelanoma DE-627 ger DE-627 rakwb eng 500 DNB LING fid John-Stephen Taylor verfasserin aut The dark side of sunlight and melanoma 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Skin cancer is the most prevalent form of cancer, with a lifetime risk of 1 in 5 for Americans . Most skin cancers can be attributed to C[arrow right]T and CC[arrow right]TT mutations in DNA resulting from cyclobutane pyrimidine dimers (CPDs) produced by the direct absorption of UVB light (290 to 320 nm) present in sunlight . The most generally accepted mechanism for the formation of these mutations is that Cs or 5-methyl-Cs in the CPDs rapidly deaminate to Us or Ts, which are then replicated in an error-free manner. One might expect that photodamage would cease once out of the Sun, but Premi et al., on page 842 of this issue, show that this is not the case in melanocytes . A substantial fraction of UV damage to DNA in these cells may be occurring in the dark, by a novel pathway with important implications for melanoma formation. Skin cancer Melanoma Sun Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 347(2015), 6224, Seite 824-824 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:347 year:2015 number:6224 pages:824-824 http://dx.doi.org/10.1126/science.aaa6578 Volltext http://search.proquest.com/docview/1656314103 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2185 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 347 2015 6224 824-824
language	English
source	Enthalten in Science 347(2015), 6224, Seite 824-824 volume:347 year:2015 number:6224 pages:824-824
sourceStr	Enthalten in Science 347(2015), 6224, Seite 824-824 volume:347 year:2015 number:6224 pages:824-824
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Skin cancer Melanoma Sun
dewey-raw	500
isfreeaccess_bool	false
container_title	Science
authorswithroles_txt_mv	John-Stephen Taylor @@aut@@
publishDateDaySort_date	2015-01-01T00:00:00Z
hierarchy_top_id	12931482X
dewey-sort	3500
id	OLC196951132X
language_de	englisch
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title	The dark side of sunlight and melanoma
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title_sort	dark side of sunlight and melanoma
title_auth	The dark side of sunlight and melanoma
abstract	Skin cancer is the most prevalent form of cancer, with a lifetime risk of 1 in 5 for Americans . Most skin cancers can be attributed to C[arrow right]T and CC[arrow right]TT mutations in DNA resulting from cyclobutane pyrimidine dimers (CPDs) produced by the direct absorption of UVB light (290 to 320 nm) present in sunlight . The most generally accepted mechanism for the formation of these mutations is that Cs or 5-methyl-Cs in the CPDs rapidly deaminate to Us or Ts, which are then replicated in an error-free manner. One might expect that photodamage would cease once out of the Sun, but Premi et al., on page 842 of this issue, show that this is not the case in melanocytes . A substantial fraction of UV damage to DNA in these cells may be occurring in the dark, by a novel pathway with important implications for melanoma formation.
abstractGer	Skin cancer is the most prevalent form of cancer, with a lifetime risk of 1 in 5 for Americans . Most skin cancers can be attributed to C[arrow right]T and CC[arrow right]TT mutations in DNA resulting from cyclobutane pyrimidine dimers (CPDs) produced by the direct absorption of UVB light (290 to 320 nm) present in sunlight . The most generally accepted mechanism for the formation of these mutations is that Cs or 5-methyl-Cs in the CPDs rapidly deaminate to Us or Ts, which are then replicated in an error-free manner. One might expect that photodamage would cease once out of the Sun, but Premi et al., on page 842 of this issue, show that this is not the case in melanocytes . A substantial fraction of UV damage to DNA in these cells may be occurring in the dark, by a novel pathway with important implications for melanoma formation.
abstract_unstemmed	Skin cancer is the most prevalent form of cancer, with a lifetime risk of 1 in 5 for Americans . Most skin cancers can be attributed to C[arrow right]T and CC[arrow right]TT mutations in DNA resulting from cyclobutane pyrimidine dimers (CPDs) produced by the direct absorption of UVB light (290 to 320 nm) present in sunlight . The most generally accepted mechanism for the formation of these mutations is that Cs or 5-methyl-Cs in the CPDs rapidly deaminate to Us or Ts, which are then replicated in an error-free manner. One might expect that photodamage would cease once out of the Sun, but Premi et al., on page 842 of this issue, show that this is not the case in melanocytes . A substantial fraction of UV damage to DNA in these cells may be occurring in the dark, by a novel pathway with important implications for melanoma formation.
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title_short	The dark side of sunlight and melanoma
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