Plant biology. Suppression of endogenous gene silencing by bidirectional cytoplasmic RNA decay in Arabidopsis

Plant immunity against foreign gene invasion takes advantage of posttranscriptional gene silencing (PTGS). How plants elaborately avert inappropriate PTGS of endogenous coding genes remains unclear. We demonstrate in Arabidopsis that both 5'-3' and 3'-5' cytoplasmic RNA decay pat...
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Autor*in:	Wu, Huihui [verfasserIn] Zhu, Ying Wen, Xing Lu, Jian Zhao, Qiong Guo, Hongwei Wang, Yichuan Shen, Yang Zhang, Chen Liu, Xiaodan Hong, Xinyu Xu, Yang Ji, Yusi Zhang, Xinyan Zhu, Ping

Format:	Artikel
Sprache:	Englisch

Erschienen:	2015

Rechteinformationen:	Nutzungsrecht: Copyright © 2015, American Association for the Advancement of Science.

Schlagwörter:	MicroRNAs - metabolism Arabidopsis - growth & development Cytoplasm - metabolism RNA, Plant - metabolism RNA Replicase - genetics RNA, Small Interfering - genetics Arabidopsis - genetics RNA, Plant - genetics Arabidopsis Proteins - genetics Arabidopsis - metabolism RNA Replicase - physiology Plant Immunity - genetics MicroRNAs - genetics Arabidopsis Proteins - physiology RNA, Small Interfering - metabolism

Übergeordnetes Werk:	Enthalten in: Science - Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883, 348(2015), 6230, Seite 120
Übergeordnetes Werk:	volume:348 ; year:2015 ; number:6230 ; pages:120

Links:	Link aufrufen

Katalog-ID:	OLC1969517395

Internformat


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520			\|a Plant immunity against foreign gene invasion takes advantage of posttranscriptional gene silencing (PTGS). How plants elaborately avert inappropriate PTGS of endogenous coding genes remains unclear. We demonstrate in Arabidopsis that both 5'-3' and 3'-5' cytoplasmic RNA decay pathways act as repressors of transgene and endogenous PTGS. Disruption of bidirectional cytoplasmic RNA decay leads to pleiotropic developmental defects and drastic transcriptomic alterations, which are substantially rescued by PTGS mutants. Upon dysfunction of bidirectional RNA decay, a large number of 21- to 22-nucleotide endogenous small interfering RNAs are produced from coding transcripts, including multiple microRNA targets, which could interfere with their cognate gene expression and functions. This study highlights the risk of unwanted PTGS and identifies cytoplasmic RNA decay pathways as safeguards of plant transcriptome and development.
540			\|a Nutzungsrecht: Copyright © 2015, American Association for the Advancement of Science.
650		4	\|a MicroRNAs - metabolism
650		4	\|a Arabidopsis - growth & development
650		4	\|a Cytoplasm - metabolism
650		4	\|a RNA, Plant - metabolism
650		4	\|a RNA Replicase - genetics
650		4	\|a RNA, Small Interfering - genetics
650		4	\|a Arabidopsis - genetics
650		4	\|a RNA, Plant - genetics
650		4	\|a Arabidopsis Proteins - genetics
650		4	\|a Arabidopsis - metabolism
650		4	\|a RNA Replicase - physiology
650		4	\|a Plant Immunity - genetics
650		4	\|a MicroRNAs - genetics
650		4	\|a Arabidopsis Proteins - physiology
650		4	\|a RNA, Small Interfering - metabolism
700	1		\|a Zhu, Ying \|4 oth
700	1		\|a Wen, Xing \|4 oth
700	1		\|a Lu, Jian \|4 oth
700	1		\|a Zhao, Qiong \|4 oth
700	1		\|a Guo, Hongwei \|4 oth
700	1		\|a Wang, Yichuan \|4 oth
700	1		\|a Shen, Yang \|4 oth
700	1		\|a Zhang, Chen \|4 oth
700	1		\|a Liu, Xiaodan \|4 oth
700	1		\|a Hong, Xinyu \|4 oth
700	1		\|a Xu, Yang \|4 oth
700	1		\|a Ji, Yusi \|4 oth
700	1		\|a Zhang, Xinyan \|4 oth
700	1		\|a Zhu, Ping \|4 oth
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856	4	2	\|u http://www.ncbi.nlm.nih.gov/pubmed/25838384
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912			\|a GBV_ILN_40
912			\|a GBV_ILN_47
912			\|a GBV_ILN_55
912			\|a GBV_ILN_59
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_92
912			\|a GBV_ILN_101
912			\|a GBV_ILN_110
912			\|a GBV_ILN_120
912			\|a GBV_ILN_131
912			\|a GBV_ILN_170
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912			\|a GBV_ILN_4317
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912			\|a GBV_ILN_4320
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4328
912			\|a GBV_ILN_4333
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Indexfelder

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matchkey_str	article:00368075:2015----::lnbooyupesooedgnugnslnigyiietoactp
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publishDate	2015
allfields	PQ20160211 (DE-627)OLC1969517395 (DE-599)GBVOLC1969517395 (PRQ)pubmed_primary_258383840 (KEY)0063888920150000348623000120plantbiologysuppressionofendogenousgenesilencingby DE-627 ger DE-627 rakwb eng 500 DNB LING fid Wu, Huihui verfasserin aut Plant biology. Suppression of endogenous gene silencing by bidirectional cytoplasmic RNA decay in Arabidopsis 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Plant immunity against foreign gene invasion takes advantage of posttranscriptional gene silencing (PTGS). How plants elaborately avert inappropriate PTGS of endogenous coding genes remains unclear. We demonstrate in Arabidopsis that both 5'-3' and 3'-5' cytoplasmic RNA decay pathways act as repressors of transgene and endogenous PTGS. Disruption of bidirectional cytoplasmic RNA decay leads to pleiotropic developmental defects and drastic transcriptomic alterations, which are substantially rescued by PTGS mutants. Upon dysfunction of bidirectional RNA decay, a large number of 21- to 22-nucleotide endogenous small interfering RNAs are produced from coding transcripts, including multiple microRNA targets, which could interfere with their cognate gene expression and functions. This study highlights the risk of unwanted PTGS and identifies cytoplasmic RNA decay pathways as safeguards of plant transcriptome and development. Nutzungsrecht: Copyright © 2015, American Association for the Advancement of Science. MicroRNAs - metabolism Arabidopsis - growth & development Cytoplasm - metabolism RNA, Plant - metabolism RNA Replicase - genetics RNA, Small Interfering - genetics Arabidopsis - genetics RNA, Plant - genetics Arabidopsis Proteins - genetics Arabidopsis - metabolism RNA Replicase - physiology Plant Immunity - genetics MicroRNAs - genetics Arabidopsis Proteins - physiology RNA, Small Interfering - metabolism Zhu, Ying oth Wen, Xing oth Lu, Jian oth Zhao, Qiong oth Guo, Hongwei oth Wang, Yichuan oth Shen, Yang oth Zhang, Chen oth Liu, Xiaodan oth Hong, Xinyu oth Xu, Yang oth Ji, Yusi oth Zhang, Xinyan oth Zhu, Ping oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 348(2015), 6230, Seite 120 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:348 year:2015 number:6230 pages:120 http://www.ncbi.nlm.nih.gov/pubmed/25838384 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2185 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 348 2015 6230 120
spelling	PQ20160211 (DE-627)OLC1969517395 (DE-599)GBVOLC1969517395 (PRQ)pubmed_primary_258383840 (KEY)0063888920150000348623000120plantbiologysuppressionofendogenousgenesilencingby DE-627 ger DE-627 rakwb eng 500 DNB LING fid Wu, Huihui verfasserin aut Plant biology. Suppression of endogenous gene silencing by bidirectional cytoplasmic RNA decay in Arabidopsis 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Plant immunity against foreign gene invasion takes advantage of posttranscriptional gene silencing (PTGS). How plants elaborately avert inappropriate PTGS of endogenous coding genes remains unclear. We demonstrate in Arabidopsis that both 5'-3' and 3'-5' cytoplasmic RNA decay pathways act as repressors of transgene and endogenous PTGS. Disruption of bidirectional cytoplasmic RNA decay leads to pleiotropic developmental defects and drastic transcriptomic alterations, which are substantially rescued by PTGS mutants. Upon dysfunction of bidirectional RNA decay, a large number of 21- to 22-nucleotide endogenous small interfering RNAs are produced from coding transcripts, including multiple microRNA targets, which could interfere with their cognate gene expression and functions. This study highlights the risk of unwanted PTGS and identifies cytoplasmic RNA decay pathways as safeguards of plant transcriptome and development. Nutzungsrecht: Copyright © 2015, American Association for the Advancement of Science. MicroRNAs - metabolism Arabidopsis - growth & development Cytoplasm - metabolism RNA, Plant - metabolism RNA Replicase - genetics RNA, Small Interfering - genetics Arabidopsis - genetics RNA, Plant - genetics Arabidopsis Proteins - genetics Arabidopsis - metabolism RNA Replicase - physiology Plant Immunity - genetics MicroRNAs - genetics Arabidopsis Proteins - physiology RNA, Small Interfering - metabolism Zhu, Ying oth Wen, Xing oth Lu, Jian oth Zhao, Qiong oth Guo, Hongwei oth Wang, Yichuan oth Shen, Yang oth Zhang, Chen oth Liu, Xiaodan oth Hong, Xinyu oth Xu, Yang oth Ji, Yusi oth Zhang, Xinyan oth Zhu, Ping oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 348(2015), 6230, Seite 120 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:348 year:2015 number:6230 pages:120 http://www.ncbi.nlm.nih.gov/pubmed/25838384 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2185 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 348 2015 6230 120
allfields_unstemmed	PQ20160211 (DE-627)OLC1969517395 (DE-599)GBVOLC1969517395 (PRQ)pubmed_primary_258383840 (KEY)0063888920150000348623000120plantbiologysuppressionofendogenousgenesilencingby DE-627 ger DE-627 rakwb eng 500 DNB LING fid Wu, Huihui verfasserin aut Plant biology. Suppression of endogenous gene silencing by bidirectional cytoplasmic RNA decay in Arabidopsis 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Plant immunity against foreign gene invasion takes advantage of posttranscriptional gene silencing (PTGS). How plants elaborately avert inappropriate PTGS of endogenous coding genes remains unclear. We demonstrate in Arabidopsis that both 5'-3' and 3'-5' cytoplasmic RNA decay pathways act as repressors of transgene and endogenous PTGS. Disruption of bidirectional cytoplasmic RNA decay leads to pleiotropic developmental defects and drastic transcriptomic alterations, which are substantially rescued by PTGS mutants. Upon dysfunction of bidirectional RNA decay, a large number of 21- to 22-nucleotide endogenous small interfering RNAs are produced from coding transcripts, including multiple microRNA targets, which could interfere with their cognate gene expression and functions. This study highlights the risk of unwanted PTGS and identifies cytoplasmic RNA decay pathways as safeguards of plant transcriptome and development. Nutzungsrecht: Copyright © 2015, American Association for the Advancement of Science. MicroRNAs - metabolism Arabidopsis - growth & development Cytoplasm - metabolism RNA, Plant - metabolism RNA Replicase - genetics RNA, Small Interfering - genetics Arabidopsis - genetics RNA, Plant - genetics Arabidopsis Proteins - genetics Arabidopsis - metabolism RNA Replicase - physiology Plant Immunity - genetics MicroRNAs - genetics Arabidopsis Proteins - physiology RNA, Small Interfering - metabolism Zhu, Ying oth Wen, Xing oth Lu, Jian oth Zhao, Qiong oth Guo, Hongwei oth Wang, Yichuan oth Shen, Yang oth Zhang, Chen oth Liu, Xiaodan oth Hong, Xinyu oth Xu, Yang oth Ji, Yusi oth Zhang, Xinyan oth Zhu, Ping oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 348(2015), 6230, Seite 120 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:348 year:2015 number:6230 pages:120 http://www.ncbi.nlm.nih.gov/pubmed/25838384 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2185 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 348 2015 6230 120
allfieldsGer	PQ20160211 (DE-627)OLC1969517395 (DE-599)GBVOLC1969517395 (PRQ)pubmed_primary_258383840 (KEY)0063888920150000348623000120plantbiologysuppressionofendogenousgenesilencingby DE-627 ger DE-627 rakwb eng 500 DNB LING fid Wu, Huihui verfasserin aut Plant biology. Suppression of endogenous gene silencing by bidirectional cytoplasmic RNA decay in Arabidopsis 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Plant immunity against foreign gene invasion takes advantage of posttranscriptional gene silencing (PTGS). How plants elaborately avert inappropriate PTGS of endogenous coding genes remains unclear. We demonstrate in Arabidopsis that both 5'-3' and 3'-5' cytoplasmic RNA decay pathways act as repressors of transgene and endogenous PTGS. Disruption of bidirectional cytoplasmic RNA decay leads to pleiotropic developmental defects and drastic transcriptomic alterations, which are substantially rescued by PTGS mutants. Upon dysfunction of bidirectional RNA decay, a large number of 21- to 22-nucleotide endogenous small interfering RNAs are produced from coding transcripts, including multiple microRNA targets, which could interfere with their cognate gene expression and functions. This study highlights the risk of unwanted PTGS and identifies cytoplasmic RNA decay pathways as safeguards of plant transcriptome and development. Nutzungsrecht: Copyright © 2015, American Association for the Advancement of Science. MicroRNAs - metabolism Arabidopsis - growth & development Cytoplasm - metabolism RNA, Plant - metabolism RNA Replicase - genetics RNA, Small Interfering - genetics Arabidopsis - genetics RNA, Plant - genetics Arabidopsis Proteins - genetics Arabidopsis - metabolism RNA Replicase - physiology Plant Immunity - genetics MicroRNAs - genetics Arabidopsis Proteins - physiology RNA, Small Interfering - metabolism Zhu, Ying oth Wen, Xing oth Lu, Jian oth Zhao, Qiong oth Guo, Hongwei oth Wang, Yichuan oth Shen, Yang oth Zhang, Chen oth Liu, Xiaodan oth Hong, Xinyu oth Xu, Yang oth Ji, Yusi oth Zhang, Xinyan oth Zhu, Ping oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 348(2015), 6230, Seite 120 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:348 year:2015 number:6230 pages:120 http://www.ncbi.nlm.nih.gov/pubmed/25838384 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2185 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 348 2015 6230 120
allfieldsSound	PQ20160211 (DE-627)OLC1969517395 (DE-599)GBVOLC1969517395 (PRQ)pubmed_primary_258383840 (KEY)0063888920150000348623000120plantbiologysuppressionofendogenousgenesilencingby DE-627 ger DE-627 rakwb eng 500 DNB LING fid Wu, Huihui verfasserin aut Plant biology. Suppression of endogenous gene silencing by bidirectional cytoplasmic RNA decay in Arabidopsis 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Plant immunity against foreign gene invasion takes advantage of posttranscriptional gene silencing (PTGS). How plants elaborately avert inappropriate PTGS of endogenous coding genes remains unclear. We demonstrate in Arabidopsis that both 5'-3' and 3'-5' cytoplasmic RNA decay pathways act as repressors of transgene and endogenous PTGS. Disruption of bidirectional cytoplasmic RNA decay leads to pleiotropic developmental defects and drastic transcriptomic alterations, which are substantially rescued by PTGS mutants. Upon dysfunction of bidirectional RNA decay, a large number of 21- to 22-nucleotide endogenous small interfering RNAs are produced from coding transcripts, including multiple microRNA targets, which could interfere with their cognate gene expression and functions. This study highlights the risk of unwanted PTGS and identifies cytoplasmic RNA decay pathways as safeguards of plant transcriptome and development. Nutzungsrecht: Copyright © 2015, American Association for the Advancement of Science. MicroRNAs - metabolism Arabidopsis - growth & development Cytoplasm - metabolism RNA, Plant - metabolism RNA Replicase - genetics RNA, Small Interfering - genetics Arabidopsis - genetics RNA, Plant - genetics Arabidopsis Proteins - genetics Arabidopsis - metabolism RNA Replicase - physiology Plant Immunity - genetics MicroRNAs - genetics Arabidopsis Proteins - physiology RNA, Small Interfering - metabolism Zhu, Ying oth Wen, Xing oth Lu, Jian oth Zhao, Qiong oth Guo, Hongwei oth Wang, Yichuan oth Shen, Yang oth Zhang, Chen oth Liu, Xiaodan oth Hong, Xinyu oth Xu, Yang oth Ji, Yusi oth Zhang, Xinyan oth Zhu, Ping oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 348(2015), 6230, Seite 120 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:348 year:2015 number:6230 pages:120 http://www.ncbi.nlm.nih.gov/pubmed/25838384 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2185 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 348 2015 6230 120
language	English
source	Enthalten in Science 348(2015), 6230, Seite 120 volume:348 year:2015 number:6230 pages:120
sourceStr	Enthalten in Science 348(2015), 6230, Seite 120 volume:348 year:2015 number:6230 pages:120
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	MicroRNAs - metabolism Arabidopsis - growth & development Cytoplasm - metabolism RNA, Plant - metabolism RNA Replicase - genetics RNA, Small Interfering - genetics Arabidopsis - genetics RNA, Plant - genetics Arabidopsis Proteins - genetics Arabidopsis - metabolism RNA Replicase - physiology Plant Immunity - genetics MicroRNAs - genetics Arabidopsis Proteins - physiology RNA, Small Interfering - metabolism
dewey-raw	500
isfreeaccess_bool	false
container_title	Science
authorswithroles_txt_mv	Wu, Huihui @@aut@@ Zhu, Ying @@oth@@ Wen, Xing @@oth@@ Lu, Jian @@oth@@ Zhao, Qiong @@oth@@ Guo, Hongwei @@oth@@ Wang, Yichuan @@oth@@ Shen, Yang @@oth@@ Zhang, Chen @@oth@@ Liu, Xiaodan @@oth@@ Hong, Xinyu @@oth@@ Xu, Yang @@oth@@ Ji, Yusi @@oth@@ Zhang, Xinyan @@oth@@ Zhu, Ping @@oth@@
publishDateDaySort_date	2015-01-01T00:00:00Z
hierarchy_top_id	12931482X
dewey-sort	3500
id	OLC1969517395
language_de	englisch
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author	Wu, Huihui
spellingShingle	Wu, Huihui ddc 500 fid LING misc MicroRNAs - metabolism misc Arabidopsis - growth & development misc Cytoplasm - metabolism misc RNA, Plant - metabolism misc RNA Replicase - genetics misc RNA, Small Interfering - genetics misc Arabidopsis - genetics misc RNA, Plant - genetics misc Arabidopsis Proteins - genetics misc Arabidopsis - metabolism misc RNA Replicase - physiology misc Plant Immunity - genetics misc MicroRNAs - genetics misc Arabidopsis Proteins - physiology misc RNA, Small Interfering - metabolism Plant biology. Suppression of endogenous gene silencing by bidirectional cytoplasmic RNA decay in Arabidopsis
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topic_title	500 DNB LING fid Plant biology. Suppression of endogenous gene silencing by bidirectional cytoplasmic RNA decay in Arabidopsis MicroRNAs - metabolism Arabidopsis - growth & development Cytoplasm - metabolism RNA, Plant - metabolism RNA Replicase - genetics RNA, Small Interfering - genetics Arabidopsis - genetics RNA, Plant - genetics Arabidopsis Proteins - genetics Arabidopsis - metabolism RNA Replicase - physiology Plant Immunity - genetics MicroRNAs - genetics Arabidopsis Proteins - physiology RNA, Small Interfering - metabolism
topic	ddc 500 fid LING misc MicroRNAs - metabolism misc Arabidopsis - growth & development misc Cytoplasm - metabolism misc RNA, Plant - metabolism misc RNA Replicase - genetics misc RNA, Small Interfering - genetics misc Arabidopsis - genetics misc RNA, Plant - genetics misc Arabidopsis Proteins - genetics misc Arabidopsis - metabolism misc RNA Replicase - physiology misc Plant Immunity - genetics misc MicroRNAs - genetics misc Arabidopsis Proteins - physiology misc RNA, Small Interfering - metabolism
topic_unstemmed	ddc 500 fid LING misc MicroRNAs - metabolism misc Arabidopsis - growth & development misc Cytoplasm - metabolism misc RNA, Plant - metabolism misc RNA Replicase - genetics misc RNA, Small Interfering - genetics misc Arabidopsis - genetics misc RNA, Plant - genetics misc Arabidopsis Proteins - genetics misc Arabidopsis - metabolism misc RNA Replicase - physiology misc Plant Immunity - genetics misc MicroRNAs - genetics misc Arabidopsis Proteins - physiology misc RNA, Small Interfering - metabolism
topic_browse	ddc 500 fid LING misc MicroRNAs - metabolism misc Arabidopsis - growth & development misc Cytoplasm - metabolism misc RNA, Plant - metabolism misc RNA Replicase - genetics misc RNA, Small Interfering - genetics misc Arabidopsis - genetics misc RNA, Plant - genetics misc Arabidopsis Proteins - genetics misc Arabidopsis - metabolism misc RNA Replicase - physiology misc Plant Immunity - genetics misc MicroRNAs - genetics misc Arabidopsis Proteins - physiology misc RNA, Small Interfering - metabolism
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title	Plant biology. Suppression of endogenous gene silencing by bidirectional cytoplasmic RNA decay in Arabidopsis
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title_full	Plant biology. Suppression of endogenous gene silencing by bidirectional cytoplasmic RNA decay in Arabidopsis
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title_sort	plant biology. suppression of endogenous gene silencing by bidirectional cytoplasmic rna decay in arabidopsis
title_auth	Plant biology. Suppression of endogenous gene silencing by bidirectional cytoplasmic RNA decay in Arabidopsis
abstract	Plant immunity against foreign gene invasion takes advantage of posttranscriptional gene silencing (PTGS). How plants elaborately avert inappropriate PTGS of endogenous coding genes remains unclear. We demonstrate in Arabidopsis that both 5'-3' and 3'-5' cytoplasmic RNA decay pathways act as repressors of transgene and endogenous PTGS. Disruption of bidirectional cytoplasmic RNA decay leads to pleiotropic developmental defects and drastic transcriptomic alterations, which are substantially rescued by PTGS mutants. Upon dysfunction of bidirectional RNA decay, a large number of 21- to 22-nucleotide endogenous small interfering RNAs are produced from coding transcripts, including multiple microRNA targets, which could interfere with their cognate gene expression and functions. This study highlights the risk of unwanted PTGS and identifies cytoplasmic RNA decay pathways as safeguards of plant transcriptome and development.
abstractGer	Plant immunity against foreign gene invasion takes advantage of posttranscriptional gene silencing (PTGS). How plants elaborately avert inappropriate PTGS of endogenous coding genes remains unclear. We demonstrate in Arabidopsis that both 5'-3' and 3'-5' cytoplasmic RNA decay pathways act as repressors of transgene and endogenous PTGS. Disruption of bidirectional cytoplasmic RNA decay leads to pleiotropic developmental defects and drastic transcriptomic alterations, which are substantially rescued by PTGS mutants. Upon dysfunction of bidirectional RNA decay, a large number of 21- to 22-nucleotide endogenous small interfering RNAs are produced from coding transcripts, including multiple microRNA targets, which could interfere with their cognate gene expression and functions. This study highlights the risk of unwanted PTGS and identifies cytoplasmic RNA decay pathways as safeguards of plant transcriptome and development.
abstract_unstemmed	Plant immunity against foreign gene invasion takes advantage of posttranscriptional gene silencing (PTGS). How plants elaborately avert inappropriate PTGS of endogenous coding genes remains unclear. We demonstrate in Arabidopsis that both 5'-3' and 3'-5' cytoplasmic RNA decay pathways act as repressors of transgene and endogenous PTGS. Disruption of bidirectional cytoplasmic RNA decay leads to pleiotropic developmental defects and drastic transcriptomic alterations, which are substantially rescued by PTGS mutants. Upon dysfunction of bidirectional RNA decay, a large number of 21- to 22-nucleotide endogenous small interfering RNAs are produced from coding transcripts, including multiple microRNA targets, which could interfere with their cognate gene expression and functions. This study highlights the risk of unwanted PTGS and identifies cytoplasmic RNA decay pathways as safeguards of plant transcriptome and development.
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title_short	Plant biology. Suppression of endogenous gene silencing by bidirectional cytoplasmic RNA decay in Arabidopsis
url	http://www.ncbi.nlm.nih.gov/pubmed/25838384
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author2	Zhu, Ying Wen, Xing Lu, Jian Zhao, Qiong Guo, Hongwei Wang, Yichuan Shen, Yang Zhang, Chen Liu, Xiaodan Hong, Xinyu Xu, Yang Ji, Yusi Zhang, Xinyan Zhu, Ping
author2Str	Zhu, Ying Wen, Xing Lu, Jian Zhao, Qiong Guo, Hongwei Wang, Yichuan Shen, Yang Zhang, Chen Liu, Xiaodan Hong, Xinyu Xu, Yang Ji, Yusi Zhang, Xinyan Zhu, Ping
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Plant biology. Suppression of endogenous gene silencing by bidirectional cytoplasmic RNA decay in Arabidopsis

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