Embryo development. A cysteine-clamp gene drives embryo polarity in the midge Chironomus

In the fruit fly Drosophila, head formation is driven by a single gene, bicoid, which generates head-to-tail polarity of the main embryonic axis. Bicoid deficiency results in embryos with tail-to-tail polarity and no head. However, most insects lack bicoid, and the molecular mechanism for establishi...
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Autor*in:	Lemke, Steffen [verfasserIn] Athy, Derek Bloch, Natasha I Sandmann, Thomas Kwan, Chun Wai Klomp, Jeff Schmidt-Ott, Urs

Format:	Artikel
Sprache:	Englisch

Erschienen:	2015

Rechteinformationen:	Nutzungsrecht: Copyright © 2015, American Association for the Advancement of Science.

Schlagwörter:	Protein Structure, Tertiary - genetics DNA-Binding Proteins - classification DNA-Binding Proteins - physiology Homeodomain Proteins - physiology Chironomidae - genetics Homeodomain Proteins - genetics Chironomidae - embryology Homeodomain Proteins - classification Body Patterning - genetics DNA-Binding Proteins - genetics Embryo, Nonmammalian - embryology Trans-Activators - classification Trans-Activators - physiology Trans-Activators - genetics

Übergeordnetes Werk:	Enthalten in: Science - Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883, 348(2015), 6238, Seite 1040
Übergeordnetes Werk:	volume:348 ; year:2015 ; number:6238 ; pages:1040

Links:	Link aufrufen

Katalog-ID:	OLC1969526246

Internformat


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245	1	0	\|a Embryo development. A cysteine-clamp gene drives embryo polarity in the midge Chironomus
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520			\|a In the fruit fly Drosophila, head formation is driven by a single gene, bicoid, which generates head-to-tail polarity of the main embryonic axis. Bicoid deficiency results in embryos with tail-to-tail polarity and no head. However, most insects lack bicoid, and the molecular mechanism for establishing head-to-tail polarity is poorly understood. We have identified a gene that establishes head-to-tail polarity of the mosquito-like midge, Chironomus riparius. This gene, named panish, encodes a cysteine-clamp DNA binding domain and operates through a different mechanism than bicoid. This finding, combined with the observation that the phylogenetic distributions of panish and bicoid are limited to specific families of flies, reveals frequent evolutionary changes of body axis determinants and a remarkable opportunity to study gene regulatory network evolution.
540			\|a Nutzungsrecht: Copyright © 2015, American Association for the Advancement of Science.
650		4	\|a Protein Structure, Tertiary - genetics
650		4	\|a DNA-Binding Proteins - classification
650		4	\|a DNA-Binding Proteins - physiology
650		4	\|a Homeodomain Proteins - physiology
650		4	\|a Chironomidae - genetics
650		4	\|a Homeodomain Proteins - genetics
650		4	\|a Chironomidae - embryology
650		4	\|a Homeodomain Proteins - classification
650		4	\|a Body Patterning - genetics
650		4	\|a DNA-Binding Proteins - genetics
650		4	\|a Embryo, Nonmammalian - embryology
650		4	\|a Trans-Activators - classification
650		4	\|a Trans-Activators - physiology
650		4	\|a Trans-Activators - genetics
700	1		\|a Athy, Derek \|4 oth
700	1		\|a Bloch, Natasha I \|4 oth
700	1		\|a Sandmann, Thomas \|4 oth
700	1		\|a Kwan, Chun Wai \|4 oth
700	1		\|a Klomp, Jeff \|4 oth
700	1		\|a Schmidt-Ott, Urs \|4 oth
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Indexfelder

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matchkey_str	article:00368075:2015----::mroeeomnaytielmgndieebyplrt
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publishDate	2015
allfields	PQ20160211 (DE-627)OLC1969526246 (DE-599)GBVOLC1969526246 (PRQ)pubmed_primary_259538210 (KEY)0063888920150000348623801040embryodevelopmentacysteineclampgenedrivesembryopol DE-627 ger DE-627 rakwb eng 500 DNB LING fid Lemke, Steffen verfasserin aut Embryo development. A cysteine-clamp gene drives embryo polarity in the midge Chironomus 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier In the fruit fly Drosophila, head formation is driven by a single gene, bicoid, which generates head-to-tail polarity of the main embryonic axis. Bicoid deficiency results in embryos with tail-to-tail polarity and no head. However, most insects lack bicoid, and the molecular mechanism for establishing head-to-tail polarity is poorly understood. We have identified a gene that establishes head-to-tail polarity of the mosquito-like midge, Chironomus riparius. This gene, named panish, encodes a cysteine-clamp DNA binding domain and operates through a different mechanism than bicoid. This finding, combined with the observation that the phylogenetic distributions of panish and bicoid are limited to specific families of flies, reveals frequent evolutionary changes of body axis determinants and a remarkable opportunity to study gene regulatory network evolution. Nutzungsrecht: Copyright © 2015, American Association for the Advancement of Science. Protein Structure, Tertiary - genetics DNA-Binding Proteins - classification DNA-Binding Proteins - physiology Homeodomain Proteins - physiology Chironomidae - genetics Homeodomain Proteins - genetics Chironomidae - embryology Homeodomain Proteins - classification Body Patterning - genetics DNA-Binding Proteins - genetics Embryo, Nonmammalian - embryology Trans-Activators - classification Trans-Activators - physiology Trans-Activators - genetics Athy, Derek oth Bloch, Natasha I oth Sandmann, Thomas oth Kwan, Chun Wai oth Klomp, Jeff oth Schmidt-Ott, Urs oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 348(2015), 6238, Seite 1040 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:348 year:2015 number:6238 pages:1040 http://www.ncbi.nlm.nih.gov/pubmed/25953821 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2185 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 348 2015 6238 1040
spelling	PQ20160211 (DE-627)OLC1969526246 (DE-599)GBVOLC1969526246 (PRQ)pubmed_primary_259538210 (KEY)0063888920150000348623801040embryodevelopmentacysteineclampgenedrivesembryopol DE-627 ger DE-627 rakwb eng 500 DNB LING fid Lemke, Steffen verfasserin aut Embryo development. A cysteine-clamp gene drives embryo polarity in the midge Chironomus 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier In the fruit fly Drosophila, head formation is driven by a single gene, bicoid, which generates head-to-tail polarity of the main embryonic axis. Bicoid deficiency results in embryos with tail-to-tail polarity and no head. However, most insects lack bicoid, and the molecular mechanism for establishing head-to-tail polarity is poorly understood. We have identified a gene that establishes head-to-tail polarity of the mosquito-like midge, Chironomus riparius. This gene, named panish, encodes a cysteine-clamp DNA binding domain and operates through a different mechanism than bicoid. This finding, combined with the observation that the phylogenetic distributions of panish and bicoid are limited to specific families of flies, reveals frequent evolutionary changes of body axis determinants and a remarkable opportunity to study gene regulatory network evolution. Nutzungsrecht: Copyright © 2015, American Association for the Advancement of Science. Protein Structure, Tertiary - genetics DNA-Binding Proteins - classification DNA-Binding Proteins - physiology Homeodomain Proteins - physiology Chironomidae - genetics Homeodomain Proteins - genetics Chironomidae - embryology Homeodomain Proteins - classification Body Patterning - genetics DNA-Binding Proteins - genetics Embryo, Nonmammalian - embryology Trans-Activators - classification Trans-Activators - physiology Trans-Activators - genetics Athy, Derek oth Bloch, Natasha I oth Sandmann, Thomas oth Kwan, Chun Wai oth Klomp, Jeff oth Schmidt-Ott, Urs oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 348(2015), 6238, Seite 1040 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:348 year:2015 number:6238 pages:1040 http://www.ncbi.nlm.nih.gov/pubmed/25953821 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2185 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 348 2015 6238 1040
allfields_unstemmed	PQ20160211 (DE-627)OLC1969526246 (DE-599)GBVOLC1969526246 (PRQ)pubmed_primary_259538210 (KEY)0063888920150000348623801040embryodevelopmentacysteineclampgenedrivesembryopol DE-627 ger DE-627 rakwb eng 500 DNB LING fid Lemke, Steffen verfasserin aut Embryo development. A cysteine-clamp gene drives embryo polarity in the midge Chironomus 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier In the fruit fly Drosophila, head formation is driven by a single gene, bicoid, which generates head-to-tail polarity of the main embryonic axis. Bicoid deficiency results in embryos with tail-to-tail polarity and no head. However, most insects lack bicoid, and the molecular mechanism for establishing head-to-tail polarity is poorly understood. We have identified a gene that establishes head-to-tail polarity of the mosquito-like midge, Chironomus riparius. This gene, named panish, encodes a cysteine-clamp DNA binding domain and operates through a different mechanism than bicoid. This finding, combined with the observation that the phylogenetic distributions of panish and bicoid are limited to specific families of flies, reveals frequent evolutionary changes of body axis determinants and a remarkable opportunity to study gene regulatory network evolution. Nutzungsrecht: Copyright © 2015, American Association for the Advancement of Science. Protein Structure, Tertiary - genetics DNA-Binding Proteins - classification DNA-Binding Proteins - physiology Homeodomain Proteins - physiology Chironomidae - genetics Homeodomain Proteins - genetics Chironomidae - embryology Homeodomain Proteins - classification Body Patterning - genetics DNA-Binding Proteins - genetics Embryo, Nonmammalian - embryology Trans-Activators - classification Trans-Activators - physiology Trans-Activators - genetics Athy, Derek oth Bloch, Natasha I oth Sandmann, Thomas oth Kwan, Chun Wai oth Klomp, Jeff oth Schmidt-Ott, Urs oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 348(2015), 6238, Seite 1040 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:348 year:2015 number:6238 pages:1040 http://www.ncbi.nlm.nih.gov/pubmed/25953821 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2185 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 348 2015 6238 1040
allfieldsGer	PQ20160211 (DE-627)OLC1969526246 (DE-599)GBVOLC1969526246 (PRQ)pubmed_primary_259538210 (KEY)0063888920150000348623801040embryodevelopmentacysteineclampgenedrivesembryopol DE-627 ger DE-627 rakwb eng 500 DNB LING fid Lemke, Steffen verfasserin aut Embryo development. A cysteine-clamp gene drives embryo polarity in the midge Chironomus 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier In the fruit fly Drosophila, head formation is driven by a single gene, bicoid, which generates head-to-tail polarity of the main embryonic axis. Bicoid deficiency results in embryos with tail-to-tail polarity and no head. However, most insects lack bicoid, and the molecular mechanism for establishing head-to-tail polarity is poorly understood. We have identified a gene that establishes head-to-tail polarity of the mosquito-like midge, Chironomus riparius. This gene, named panish, encodes a cysteine-clamp DNA binding domain and operates through a different mechanism than bicoid. This finding, combined with the observation that the phylogenetic distributions of panish and bicoid are limited to specific families of flies, reveals frequent evolutionary changes of body axis determinants and a remarkable opportunity to study gene regulatory network evolution. Nutzungsrecht: Copyright © 2015, American Association for the Advancement of Science. Protein Structure, Tertiary - genetics DNA-Binding Proteins - classification DNA-Binding Proteins - physiology Homeodomain Proteins - physiology Chironomidae - genetics Homeodomain Proteins - genetics Chironomidae - embryology Homeodomain Proteins - classification Body Patterning - genetics DNA-Binding Proteins - genetics Embryo, Nonmammalian - embryology Trans-Activators - classification Trans-Activators - physiology Trans-Activators - genetics Athy, Derek oth Bloch, Natasha I oth Sandmann, Thomas oth Kwan, Chun Wai oth Klomp, Jeff oth Schmidt-Ott, Urs oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 348(2015), 6238, Seite 1040 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:348 year:2015 number:6238 pages:1040 http://www.ncbi.nlm.nih.gov/pubmed/25953821 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2185 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 348 2015 6238 1040
allfieldsSound	PQ20160211 (DE-627)OLC1969526246 (DE-599)GBVOLC1969526246 (PRQ)pubmed_primary_259538210 (KEY)0063888920150000348623801040embryodevelopmentacysteineclampgenedrivesembryopol DE-627 ger DE-627 rakwb eng 500 DNB LING fid Lemke, Steffen verfasserin aut Embryo development. A cysteine-clamp gene drives embryo polarity in the midge Chironomus 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier In the fruit fly Drosophila, head formation is driven by a single gene, bicoid, which generates head-to-tail polarity of the main embryonic axis. Bicoid deficiency results in embryos with tail-to-tail polarity and no head. However, most insects lack bicoid, and the molecular mechanism for establishing head-to-tail polarity is poorly understood. We have identified a gene that establishes head-to-tail polarity of the mosquito-like midge, Chironomus riparius. This gene, named panish, encodes a cysteine-clamp DNA binding domain and operates through a different mechanism than bicoid. This finding, combined with the observation that the phylogenetic distributions of panish and bicoid are limited to specific families of flies, reveals frequent evolutionary changes of body axis determinants and a remarkable opportunity to study gene regulatory network evolution. Nutzungsrecht: Copyright © 2015, American Association for the Advancement of Science. Protein Structure, Tertiary - genetics DNA-Binding Proteins - classification DNA-Binding Proteins - physiology Homeodomain Proteins - physiology Chironomidae - genetics Homeodomain Proteins - genetics Chironomidae - embryology Homeodomain Proteins - classification Body Patterning - genetics DNA-Binding Proteins - genetics Embryo, Nonmammalian - embryology Trans-Activators - classification Trans-Activators - physiology Trans-Activators - genetics Athy, Derek oth Bloch, Natasha I oth Sandmann, Thomas oth Kwan, Chun Wai oth Klomp, Jeff oth Schmidt-Ott, Urs oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 348(2015), 6238, Seite 1040 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:348 year:2015 number:6238 pages:1040 http://www.ncbi.nlm.nih.gov/pubmed/25953821 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2185 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 348 2015 6238 1040
language	English
source	Enthalten in Science 348(2015), 6238, Seite 1040 volume:348 year:2015 number:6238 pages:1040
sourceStr	Enthalten in Science 348(2015), 6238, Seite 1040 volume:348 year:2015 number:6238 pages:1040
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Protein Structure, Tertiary - genetics DNA-Binding Proteins - classification DNA-Binding Proteins - physiology Homeodomain Proteins - physiology Chironomidae - genetics Homeodomain Proteins - genetics Chironomidae - embryology Homeodomain Proteins - classification Body Patterning - genetics DNA-Binding Proteins - genetics Embryo, Nonmammalian - embryology Trans-Activators - classification Trans-Activators - physiology Trans-Activators - genetics
dewey-raw	500
isfreeaccess_bool	false
container_title	Science
authorswithroles_txt_mv	Lemke, Steffen @@aut@@ Athy, Derek @@oth@@ Bloch, Natasha I @@oth@@ Sandmann, Thomas @@oth@@ Kwan, Chun Wai @@oth@@ Klomp, Jeff @@oth@@ Schmidt-Ott, Urs @@oth@@
publishDateDaySort_date	2015-01-01T00:00:00Z
hierarchy_top_id	12931482X
dewey-sort	3500
id	OLC1969526246
language_de	englisch
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author	Lemke, Steffen
spellingShingle	Lemke, Steffen ddc 500 fid LING misc Protein Structure, Tertiary - genetics misc DNA-Binding Proteins - classification misc DNA-Binding Proteins - physiology misc Homeodomain Proteins - physiology misc Chironomidae - genetics misc Homeodomain Proteins - genetics misc Chironomidae - embryology misc Homeodomain Proteins - classification misc Body Patterning - genetics misc DNA-Binding Proteins - genetics misc Embryo, Nonmammalian - embryology misc Trans-Activators - classification misc Trans-Activators - physiology misc Trans-Activators - genetics Embryo development. A cysteine-clamp gene drives embryo polarity in the midge Chironomus
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topic_title	500 DNB LING fid Embryo development. A cysteine-clamp gene drives embryo polarity in the midge Chironomus Protein Structure, Tertiary - genetics DNA-Binding Proteins - classification DNA-Binding Proteins - physiology Homeodomain Proteins - physiology Chironomidae - genetics Homeodomain Proteins - genetics Chironomidae - embryology Homeodomain Proteins - classification Body Patterning - genetics DNA-Binding Proteins - genetics Embryo, Nonmammalian - embryology Trans-Activators - classification Trans-Activators - physiology Trans-Activators - genetics
topic	ddc 500 fid LING misc Protein Structure, Tertiary - genetics misc DNA-Binding Proteins - classification misc DNA-Binding Proteins - physiology misc Homeodomain Proteins - physiology misc Chironomidae - genetics misc Homeodomain Proteins - genetics misc Chironomidae - embryology misc Homeodomain Proteins - classification misc Body Patterning - genetics misc DNA-Binding Proteins - genetics misc Embryo, Nonmammalian - embryology misc Trans-Activators - classification misc Trans-Activators - physiology misc Trans-Activators - genetics
topic_unstemmed	ddc 500 fid LING misc Protein Structure, Tertiary - genetics misc DNA-Binding Proteins - classification misc DNA-Binding Proteins - physiology misc Homeodomain Proteins - physiology misc Chironomidae - genetics misc Homeodomain Proteins - genetics misc Chironomidae - embryology misc Homeodomain Proteins - classification misc Body Patterning - genetics misc DNA-Binding Proteins - genetics misc Embryo, Nonmammalian - embryology misc Trans-Activators - classification misc Trans-Activators - physiology misc Trans-Activators - genetics
topic_browse	ddc 500 fid LING misc Protein Structure, Tertiary - genetics misc DNA-Binding Proteins - classification misc DNA-Binding Proteins - physiology misc Homeodomain Proteins - physiology misc Chironomidae - genetics misc Homeodomain Proteins - genetics misc Chironomidae - embryology misc Homeodomain Proteins - classification misc Body Patterning - genetics misc DNA-Binding Proteins - genetics misc Embryo, Nonmammalian - embryology misc Trans-Activators - classification misc Trans-Activators - physiology misc Trans-Activators - genetics
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title	Embryo development. A cysteine-clamp gene drives embryo polarity in the midge Chironomus
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title_full	Embryo development. A cysteine-clamp gene drives embryo polarity in the midge Chironomus
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title_sort	embryo development. a cysteine-clamp gene drives embryo polarity in the midge chironomus
title_auth	Embryo development. A cysteine-clamp gene drives embryo polarity in the midge Chironomus
abstract	In the fruit fly Drosophila, head formation is driven by a single gene, bicoid, which generates head-to-tail polarity of the main embryonic axis. Bicoid deficiency results in embryos with tail-to-tail polarity and no head. However, most insects lack bicoid, and the molecular mechanism for establishing head-to-tail polarity is poorly understood. We have identified a gene that establishes head-to-tail polarity of the mosquito-like midge, Chironomus riparius. This gene, named panish, encodes a cysteine-clamp DNA binding domain and operates through a different mechanism than bicoid. This finding, combined with the observation that the phylogenetic distributions of panish and bicoid are limited to specific families of flies, reveals frequent evolutionary changes of body axis determinants and a remarkable opportunity to study gene regulatory network evolution.
abstractGer	In the fruit fly Drosophila, head formation is driven by a single gene, bicoid, which generates head-to-tail polarity of the main embryonic axis. Bicoid deficiency results in embryos with tail-to-tail polarity and no head. However, most insects lack bicoid, and the molecular mechanism for establishing head-to-tail polarity is poorly understood. We have identified a gene that establishes head-to-tail polarity of the mosquito-like midge, Chironomus riparius. This gene, named panish, encodes a cysteine-clamp DNA binding domain and operates through a different mechanism than bicoid. This finding, combined with the observation that the phylogenetic distributions of panish and bicoid are limited to specific families of flies, reveals frequent evolutionary changes of body axis determinants and a remarkable opportunity to study gene regulatory network evolution.
abstract_unstemmed	In the fruit fly Drosophila, head formation is driven by a single gene, bicoid, which generates head-to-tail polarity of the main embryonic axis. Bicoid deficiency results in embryos with tail-to-tail polarity and no head. However, most insects lack bicoid, and the molecular mechanism for establishing head-to-tail polarity is poorly understood. We have identified a gene that establishes head-to-tail polarity of the mosquito-like midge, Chironomus riparius. This gene, named panish, encodes a cysteine-clamp DNA binding domain and operates through a different mechanism than bicoid. This finding, combined with the observation that the phylogenetic distributions of panish and bicoid are limited to specific families of flies, reveals frequent evolutionary changes of body axis determinants and a remarkable opportunity to study gene regulatory network evolution.
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container_issue	6238
title_short	Embryo development. A cysteine-clamp gene drives embryo polarity in the midge Chironomus
url	http://www.ncbi.nlm.nih.gov/pubmed/25953821
remote_bool	false
author2	Athy, Derek Bloch, Natasha I Sandmann, Thomas Kwan, Chun Wai Klomp, Jeff Schmidt-Ott, Urs
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Embryo development. A cysteine-clamp gene drives embryo polarity in the midge Chironomus

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