Blocking stress response for better memory?

Two years ago, a small molecule was discovered that enhanced the memory of rodents . Pinpointing the target of this compound, called integrated stress response inhibitor (ISRIB), could guide the development of cognitive disorder treatments. Two groups have now identified a target. On page 1027 of th...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Alan G Hinnebusch [verfasserIn]

Format:	Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Eukaryotes Kinases Stress Protein synthesis Memory Pharmacology

Übergeordnetes Werk:	Enthalten in: Science - Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883, 348(2015), 6238, Seite 967-968
Übergeordnetes Werk:	volume:348 ; year:2015 ; number:6238 ; pages:967-968

Links:	Volltext Link aufrufen

DOI / URN:	10.1126/science.aac4832

Katalog-ID:	OLC1969526297

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allfields	10.1126/science.aac4832 doi PQ20160211 (DE-627)OLC1969526297 (DE-599)GBVOLC1969526297 (PRQ)c1801-1ee88b2e6a6f1c1f18838f0346f9473506c7b7bc28d6ca177ebf822603d833f30 (KEY)0063888920150000348623800967blockingstressresponseforbettermemory DE-627 ger DE-627 rakwb eng 500 DNB LING fid Alan G Hinnebusch verfasserin aut Blocking stress response for better memory? 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Two years ago, a small molecule was discovered that enhanced the memory of rodents . Pinpointing the target of this compound, called integrated stress response inhibitor (ISRIB), could guide the development of cognitive disorder treatments. Two groups have now identified a target. On page 1027 of this issue, Sekine et al. report, as do Sidrauski et al. , that ISRIB increases the activity of eukaryotic translation initiation factor 2B (eIF2B), a factor that regulates protein synthesis in a pathway underlying the cellular response to stress. Eukaryotes Kinases Stress Protein synthesis Memory Pharmacology Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 348(2015), 6238, Seite 967-968 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:348 year:2015 number:6238 pages:967-968 http://dx.doi.org/10.1126/science.aac4832 Volltext http://search.proquest.com/docview/1683750101 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2185 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 348 2015 6238 967-968
spelling	10.1126/science.aac4832 doi PQ20160211 (DE-627)OLC1969526297 (DE-599)GBVOLC1969526297 (PRQ)c1801-1ee88b2e6a6f1c1f18838f0346f9473506c7b7bc28d6ca177ebf822603d833f30 (KEY)0063888920150000348623800967blockingstressresponseforbettermemory DE-627 ger DE-627 rakwb eng 500 DNB LING fid Alan G Hinnebusch verfasserin aut Blocking stress response for better memory? 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Two years ago, a small molecule was discovered that enhanced the memory of rodents . Pinpointing the target of this compound, called integrated stress response inhibitor (ISRIB), could guide the development of cognitive disorder treatments. Two groups have now identified a target. On page 1027 of this issue, Sekine et al. report, as do Sidrauski et al. , that ISRIB increases the activity of eukaryotic translation initiation factor 2B (eIF2B), a factor that regulates protein synthesis in a pathway underlying the cellular response to stress. Eukaryotes Kinases Stress Protein synthesis Memory Pharmacology Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 348(2015), 6238, Seite 967-968 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:348 year:2015 number:6238 pages:967-968 http://dx.doi.org/10.1126/science.aac4832 Volltext http://search.proquest.com/docview/1683750101 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2185 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 348 2015 6238 967-968
allfields_unstemmed	10.1126/science.aac4832 doi PQ20160211 (DE-627)OLC1969526297 (DE-599)GBVOLC1969526297 (PRQ)c1801-1ee88b2e6a6f1c1f18838f0346f9473506c7b7bc28d6ca177ebf822603d833f30 (KEY)0063888920150000348623800967blockingstressresponseforbettermemory DE-627 ger DE-627 rakwb eng 500 DNB LING fid Alan G Hinnebusch verfasserin aut Blocking stress response for better memory? 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Two years ago, a small molecule was discovered that enhanced the memory of rodents . Pinpointing the target of this compound, called integrated stress response inhibitor (ISRIB), could guide the development of cognitive disorder treatments. Two groups have now identified a target. On page 1027 of this issue, Sekine et al. report, as do Sidrauski et al. , that ISRIB increases the activity of eukaryotic translation initiation factor 2B (eIF2B), a factor that regulates protein synthesis in a pathway underlying the cellular response to stress. Eukaryotes Kinases Stress Protein synthesis Memory Pharmacology Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 348(2015), 6238, Seite 967-968 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:348 year:2015 number:6238 pages:967-968 http://dx.doi.org/10.1126/science.aac4832 Volltext http://search.proquest.com/docview/1683750101 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2185 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 348 2015 6238 967-968
allfieldsGer	10.1126/science.aac4832 doi PQ20160211 (DE-627)OLC1969526297 (DE-599)GBVOLC1969526297 (PRQ)c1801-1ee88b2e6a6f1c1f18838f0346f9473506c7b7bc28d6ca177ebf822603d833f30 (KEY)0063888920150000348623800967blockingstressresponseforbettermemory DE-627 ger DE-627 rakwb eng 500 DNB LING fid Alan G Hinnebusch verfasserin aut Blocking stress response for better memory? 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Two years ago, a small molecule was discovered that enhanced the memory of rodents . Pinpointing the target of this compound, called integrated stress response inhibitor (ISRIB), could guide the development of cognitive disorder treatments. Two groups have now identified a target. On page 1027 of this issue, Sekine et al. report, as do Sidrauski et al. , that ISRIB increases the activity of eukaryotic translation initiation factor 2B (eIF2B), a factor that regulates protein synthesis in a pathway underlying the cellular response to stress. Eukaryotes Kinases Stress Protein synthesis Memory Pharmacology Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 348(2015), 6238, Seite 967-968 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:348 year:2015 number:6238 pages:967-968 http://dx.doi.org/10.1126/science.aac4832 Volltext http://search.proquest.com/docview/1683750101 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2185 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 348 2015 6238 967-968
allfieldsSound	10.1126/science.aac4832 doi PQ20160211 (DE-627)OLC1969526297 (DE-599)GBVOLC1969526297 (PRQ)c1801-1ee88b2e6a6f1c1f18838f0346f9473506c7b7bc28d6ca177ebf822603d833f30 (KEY)0063888920150000348623800967blockingstressresponseforbettermemory DE-627 ger DE-627 rakwb eng 500 DNB LING fid Alan G Hinnebusch verfasserin aut Blocking stress response for better memory? 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Two years ago, a small molecule was discovered that enhanced the memory of rodents . Pinpointing the target of this compound, called integrated stress response inhibitor (ISRIB), could guide the development of cognitive disorder treatments. Two groups have now identified a target. On page 1027 of this issue, Sekine et al. report, as do Sidrauski et al. , that ISRIB increases the activity of eukaryotic translation initiation factor 2B (eIF2B), a factor that regulates protein synthesis in a pathway underlying the cellular response to stress. Eukaryotes Kinases Stress Protein synthesis Memory Pharmacology Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 348(2015), 6238, Seite 967-968 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:348 year:2015 number:6238 pages:967-968 http://dx.doi.org/10.1126/science.aac4832 Volltext http://search.proquest.com/docview/1683750101 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2185 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 348 2015 6238 967-968
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author	Alan G Hinnebusch
spellingShingle	Alan G Hinnebusch ddc 500 fid LING misc Eukaryotes misc Kinases misc Stress misc Protein synthesis misc Memory misc Pharmacology Blocking stress response for better memory?
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title	Blocking stress response for better memory?
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title_sort	blocking stress response for better memory?
title_auth	Blocking stress response for better memory?
abstract	Two years ago, a small molecule was discovered that enhanced the memory of rodents . Pinpointing the target of this compound, called integrated stress response inhibitor (ISRIB), could guide the development of cognitive disorder treatments. Two groups have now identified a target. On page 1027 of this issue, Sekine et al. report, as do Sidrauski et al. , that ISRIB increases the activity of eukaryotic translation initiation factor 2B (eIF2B), a factor that regulates protein synthesis in a pathway underlying the cellular response to stress.
abstractGer	Two years ago, a small molecule was discovered that enhanced the memory of rodents . Pinpointing the target of this compound, called integrated stress response inhibitor (ISRIB), could guide the development of cognitive disorder treatments. Two groups have now identified a target. On page 1027 of this issue, Sekine et al. report, as do Sidrauski et al. , that ISRIB increases the activity of eukaryotic translation initiation factor 2B (eIF2B), a factor that regulates protein synthesis in a pathway underlying the cellular response to stress.
abstract_unstemmed	Two years ago, a small molecule was discovered that enhanced the memory of rodents . Pinpointing the target of this compound, called integrated stress response inhibitor (ISRIB), could guide the development of cognitive disorder treatments. Two groups have now identified a target. On page 1027 of this issue, Sekine et al. report, as do Sidrauski et al. , that ISRIB increases the activity of eukaryotic translation initiation factor 2B (eIF2B), a factor that regulates protein synthesis in a pathway underlying the cellular response to stress.
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title_short	Blocking stress response for better memory?
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