Endosymbiotic origin and differential loss of eukaryotic genes

Chloroplasts arose from cyanobacteria, mitochondria arose from proteobacteria. Both organelles have conserved their prokaryotic biochemistry, but their genomes are reduced, and most organelle proteins are encoded in the nucleus. Endosymbiotic theory posits that bacterial genes in eukaryotic genomes...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Mayo Roettger [verfasserIn] Einat Hazkani-Covo Giddy Landan Shijulal Nelson-Sathi Chuan Ku David Bryant William F Martin Filipa L Sousa Peter J Lockhart James O Mcinerney

Format:	Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Eukaryotes Genes Evolution Phylogenetics Eukaryota - classification Archaea - genetics Gene Transfer, Horizontal - genetics Organelles - genetics Genome - genetics Prokaryotic Cells - metabolism Eukaryotic Cells - metabolism Mitochondria - genetics Symbiosis - genetics Plastids - genetics Bacteria - genetics Eukaryota - genetics Proteome - genetics Genetic research Research Genetic transformation Genetic aspects

Übergeordnetes Werk:	Enthalten in: Nature - London : Macmillan Publishers Limited, part of Springer Nature, 1869, 524(2015), 7566, Seite 427-432
Übergeordnetes Werk:	volume:524 ; year:2015 ; number:7566 ; pages:427-432

Links:	Volltext Link aufrufen Link aufrufen

DOI / URN:	10.1038/nature14963

Katalog-ID:	OLC196966374X

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520			\|a Chloroplasts arose from cyanobacteria, mitochondria arose from proteobacteria. Both organelles have conserved their prokaryotic biochemistry, but their genomes are reduced, and most organelle proteins are encoded in the nucleus. Endosymbiotic theory posits that bacterial genes in eukaryotic genomes entered the eukaryotic lineage via organelle ancestors. It predicts episodic influx of prokaryotic genes into the eukaryotic lineage, with acquisition corresponding to endosymbiotic events. Eukaryotic genome sequences, however, increasingly implicate lateral gene transfer, both from prokaryotes to eukaryotes and among eukaryotes, as a source of gene content variation in eukaryotic genomes, which predicts continuous, lineage-specific acquisition of prokaryotic genes in divergent eukaryotic groups. Here we discriminate between these two alternatives by clustering and phylogenetic analysis of eukaryotic gene families having prokaryotic homologues. Our results indicate (1) that gene transfer from bacteria to eukaryotes is episodic, as revealed by gene distributions, and coincides with major evolutionary transitions at the origin of chloroplasts and mitochondria; (2) that gene inheritance in eukaryotes is vertical, as revealed by extensive topological comparison, sparse gene distributions stemming from differential loss; and (3) that continuous, lineage-specific lateral gene transfer, although it sometimes occurs, does not contribute to long-term gene content evolution in eukaryotic genomes.
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650		4	\|a Gene Transfer, Horizontal - genetics
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allfields	10.1038/nature14963 doi PQ20160211 (DE-627)OLC196966374X (DE-599)GBVOLC196966374X (PRQ)c2229-1e063f0cded98d9066db749df5880275e647ed36dabb2862081b1d787952e1100 (KEY)0072945020150000524756600427endosymbioticoriginanddifferentiallossofeukaryotic DE-627 ger DE-627 rakwb eng 070 500 DNB 500 AVZ BIODIV fid Mayo Roettger verfasserin aut Endosymbiotic origin and differential loss of eukaryotic genes 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Chloroplasts arose from cyanobacteria, mitochondria arose from proteobacteria. Both organelles have conserved their prokaryotic biochemistry, but their genomes are reduced, and most organelle proteins are encoded in the nucleus. Endosymbiotic theory posits that bacterial genes in eukaryotic genomes entered the eukaryotic lineage via organelle ancestors. It predicts episodic influx of prokaryotic genes into the eukaryotic lineage, with acquisition corresponding to endosymbiotic events. Eukaryotic genome sequences, however, increasingly implicate lateral gene transfer, both from prokaryotes to eukaryotes and among eukaryotes, as a source of gene content variation in eukaryotic genomes, which predicts continuous, lineage-specific acquisition of prokaryotic genes in divergent eukaryotic groups. Here we discriminate between these two alternatives by clustering and phylogenetic analysis of eukaryotic gene families having prokaryotic homologues. Our results indicate (1) that gene transfer from bacteria to eukaryotes is episodic, as revealed by gene distributions, and coincides with major evolutionary transitions at the origin of chloroplasts and mitochondria; (2) that gene inheritance in eukaryotes is vertical, as revealed by extensive topological comparison, sparse gene distributions stemming from differential loss; and (3) that continuous, lineage-specific lateral gene transfer, although it sometimes occurs, does not contribute to long-term gene content evolution in eukaryotic genomes. Eukaryotes Genes Evolution Phylogenetics Eukaryota - classification Archaea - genetics Gene Transfer, Horizontal - genetics Organelles - genetics Genome - genetics Prokaryotic Cells - metabolism Eukaryotic Cells - metabolism Mitochondria - genetics Symbiosis - genetics Plastids - genetics Bacteria - genetics Eukaryota - genetics Proteome - genetics Genetic research Research Genetic transformation Genetic aspects Einat Hazkani-Covo oth Giddy Landan oth Shijulal Nelson-Sathi oth Chuan Ku oth David Bryant oth William F Martin oth Filipa L Sousa oth Peter J Lockhart oth James O Mcinerney oth Enthalten in Nature London : Macmillan Publishers Limited, part of Springer Nature, 1869 524(2015), 7566, Seite 427-432 (DE-627)129292834 (DE-600)120714-3 (DE-576)014473941 0028-0836 nnns volume:524 year:2015 number:7566 pages:427-432 http://dx.doi.org/10.1038/nature14963 Volltext http://www.ncbi.nlm.nih.gov/pubmed/26287458 http://search.proquest.com/docview/1708884522 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_30 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_100 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_154 GBV_ILN_160 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_267 GBV_ILN_290 GBV_ILN_294 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2015 GBV_ILN_2016 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2095 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4700 AR 524 2015 7566 427-432
spelling	10.1038/nature14963 doi PQ20160211 (DE-627)OLC196966374X (DE-599)GBVOLC196966374X (PRQ)c2229-1e063f0cded98d9066db749df5880275e647ed36dabb2862081b1d787952e1100 (KEY)0072945020150000524756600427endosymbioticoriginanddifferentiallossofeukaryotic DE-627 ger DE-627 rakwb eng 070 500 DNB 500 AVZ BIODIV fid Mayo Roettger verfasserin aut Endosymbiotic origin and differential loss of eukaryotic genes 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Chloroplasts arose from cyanobacteria, mitochondria arose from proteobacteria. Both organelles have conserved their prokaryotic biochemistry, but their genomes are reduced, and most organelle proteins are encoded in the nucleus. Endosymbiotic theory posits that bacterial genes in eukaryotic genomes entered the eukaryotic lineage via organelle ancestors. It predicts episodic influx of prokaryotic genes into the eukaryotic lineage, with acquisition corresponding to endosymbiotic events. Eukaryotic genome sequences, however, increasingly implicate lateral gene transfer, both from prokaryotes to eukaryotes and among eukaryotes, as a source of gene content variation in eukaryotic genomes, which predicts continuous, lineage-specific acquisition of prokaryotic genes in divergent eukaryotic groups. Here we discriminate between these two alternatives by clustering and phylogenetic analysis of eukaryotic gene families having prokaryotic homologues. Our results indicate (1) that gene transfer from bacteria to eukaryotes is episodic, as revealed by gene distributions, and coincides with major evolutionary transitions at the origin of chloroplasts and mitochondria; (2) that gene inheritance in eukaryotes is vertical, as revealed by extensive topological comparison, sparse gene distributions stemming from differential loss; and (3) that continuous, lineage-specific lateral gene transfer, although it sometimes occurs, does not contribute to long-term gene content evolution in eukaryotic genomes. Eukaryotes Genes Evolution Phylogenetics Eukaryota - classification Archaea - genetics Gene Transfer, Horizontal - genetics Organelles - genetics Genome - genetics Prokaryotic Cells - metabolism Eukaryotic Cells - metabolism Mitochondria - genetics Symbiosis - genetics Plastids - genetics Bacteria - genetics Eukaryota - genetics Proteome - genetics Genetic research Research Genetic transformation Genetic aspects Einat Hazkani-Covo oth Giddy Landan oth Shijulal Nelson-Sathi oth Chuan Ku oth David Bryant oth William F Martin oth Filipa L Sousa oth Peter J Lockhart oth James O Mcinerney oth Enthalten in Nature London : Macmillan Publishers Limited, part of Springer Nature, 1869 524(2015), 7566, Seite 427-432 (DE-627)129292834 (DE-600)120714-3 (DE-576)014473941 0028-0836 nnns volume:524 year:2015 number:7566 pages:427-432 http://dx.doi.org/10.1038/nature14963 Volltext http://www.ncbi.nlm.nih.gov/pubmed/26287458 http://search.proquest.com/docview/1708884522 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_30 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_100 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_154 GBV_ILN_160 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_267 GBV_ILN_290 GBV_ILN_294 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2015 GBV_ILN_2016 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2095 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4700 AR 524 2015 7566 427-432
allfields_unstemmed	10.1038/nature14963 doi PQ20160211 (DE-627)OLC196966374X (DE-599)GBVOLC196966374X (PRQ)c2229-1e063f0cded98d9066db749df5880275e647ed36dabb2862081b1d787952e1100 (KEY)0072945020150000524756600427endosymbioticoriginanddifferentiallossofeukaryotic DE-627 ger DE-627 rakwb eng 070 500 DNB 500 AVZ BIODIV fid Mayo Roettger verfasserin aut Endosymbiotic origin and differential loss of eukaryotic genes 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Chloroplasts arose from cyanobacteria, mitochondria arose from proteobacteria. Both organelles have conserved their prokaryotic biochemistry, but their genomes are reduced, and most organelle proteins are encoded in the nucleus. Endosymbiotic theory posits that bacterial genes in eukaryotic genomes entered the eukaryotic lineage via organelle ancestors. It predicts episodic influx of prokaryotic genes into the eukaryotic lineage, with acquisition corresponding to endosymbiotic events. Eukaryotic genome sequences, however, increasingly implicate lateral gene transfer, both from prokaryotes to eukaryotes and among eukaryotes, as a source of gene content variation in eukaryotic genomes, which predicts continuous, lineage-specific acquisition of prokaryotic genes in divergent eukaryotic groups. Here we discriminate between these two alternatives by clustering and phylogenetic analysis of eukaryotic gene families having prokaryotic homologues. Our results indicate (1) that gene transfer from bacteria to eukaryotes is episodic, as revealed by gene distributions, and coincides with major evolutionary transitions at the origin of chloroplasts and mitochondria; (2) that gene inheritance in eukaryotes is vertical, as revealed by extensive topological comparison, sparse gene distributions stemming from differential loss; and (3) that continuous, lineage-specific lateral gene transfer, although it sometimes occurs, does not contribute to long-term gene content evolution in eukaryotic genomes. Eukaryotes Genes Evolution Phylogenetics Eukaryota - classification Archaea - genetics Gene Transfer, Horizontal - genetics Organelles - genetics Genome - genetics Prokaryotic Cells - metabolism Eukaryotic Cells - metabolism Mitochondria - genetics Symbiosis - genetics Plastids - genetics Bacteria - genetics Eukaryota - genetics Proteome - genetics Genetic research Research Genetic transformation Genetic aspects Einat Hazkani-Covo oth Giddy Landan oth Shijulal Nelson-Sathi oth Chuan Ku oth David Bryant oth William F Martin oth Filipa L Sousa oth Peter J Lockhart oth James O Mcinerney oth Enthalten in Nature London : Macmillan Publishers Limited, part of Springer Nature, 1869 524(2015), 7566, Seite 427-432 (DE-627)129292834 (DE-600)120714-3 (DE-576)014473941 0028-0836 nnns volume:524 year:2015 number:7566 pages:427-432 http://dx.doi.org/10.1038/nature14963 Volltext http://www.ncbi.nlm.nih.gov/pubmed/26287458 http://search.proquest.com/docview/1708884522 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_30 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_100 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_154 GBV_ILN_160 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_267 GBV_ILN_290 GBV_ILN_294 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2015 GBV_ILN_2016 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2095 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4700 AR 524 2015 7566 427-432
allfieldsGer	10.1038/nature14963 doi PQ20160211 (DE-627)OLC196966374X (DE-599)GBVOLC196966374X (PRQ)c2229-1e063f0cded98d9066db749df5880275e647ed36dabb2862081b1d787952e1100 (KEY)0072945020150000524756600427endosymbioticoriginanddifferentiallossofeukaryotic DE-627 ger DE-627 rakwb eng 070 500 DNB 500 AVZ BIODIV fid Mayo Roettger verfasserin aut Endosymbiotic origin and differential loss of eukaryotic genes 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Chloroplasts arose from cyanobacteria, mitochondria arose from proteobacteria. Both organelles have conserved their prokaryotic biochemistry, but their genomes are reduced, and most organelle proteins are encoded in the nucleus. Endosymbiotic theory posits that bacterial genes in eukaryotic genomes entered the eukaryotic lineage via organelle ancestors. It predicts episodic influx of prokaryotic genes into the eukaryotic lineage, with acquisition corresponding to endosymbiotic events. Eukaryotic genome sequences, however, increasingly implicate lateral gene transfer, both from prokaryotes to eukaryotes and among eukaryotes, as a source of gene content variation in eukaryotic genomes, which predicts continuous, lineage-specific acquisition of prokaryotic genes in divergent eukaryotic groups. Here we discriminate between these two alternatives by clustering and phylogenetic analysis of eukaryotic gene families having prokaryotic homologues. Our results indicate (1) that gene transfer from bacteria to eukaryotes is episodic, as revealed by gene distributions, and coincides with major evolutionary transitions at the origin of chloroplasts and mitochondria; (2) that gene inheritance in eukaryotes is vertical, as revealed by extensive topological comparison, sparse gene distributions stemming from differential loss; and (3) that continuous, lineage-specific lateral gene transfer, although it sometimes occurs, does not contribute to long-term gene content evolution in eukaryotic genomes. Eukaryotes Genes Evolution Phylogenetics Eukaryota - classification Archaea - genetics Gene Transfer, Horizontal - genetics Organelles - genetics Genome - genetics Prokaryotic Cells - metabolism Eukaryotic Cells - metabolism Mitochondria - genetics Symbiosis - genetics Plastids - genetics Bacteria - genetics Eukaryota - genetics Proteome - genetics Genetic research Research Genetic transformation Genetic aspects Einat Hazkani-Covo oth Giddy Landan oth Shijulal Nelson-Sathi oth Chuan Ku oth David Bryant oth William F Martin oth Filipa L Sousa oth Peter J Lockhart oth James O Mcinerney oth Enthalten in Nature London : Macmillan Publishers Limited, part of Springer Nature, 1869 524(2015), 7566, Seite 427-432 (DE-627)129292834 (DE-600)120714-3 (DE-576)014473941 0028-0836 nnns volume:524 year:2015 number:7566 pages:427-432 http://dx.doi.org/10.1038/nature14963 Volltext http://www.ncbi.nlm.nih.gov/pubmed/26287458 http://search.proquest.com/docview/1708884522 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_30 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_100 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_154 GBV_ILN_160 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_267 GBV_ILN_290 GBV_ILN_294 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2015 GBV_ILN_2016 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2095 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4700 AR 524 2015 7566 427-432
allfieldsSound	10.1038/nature14963 doi PQ20160211 (DE-627)OLC196966374X (DE-599)GBVOLC196966374X (PRQ)c2229-1e063f0cded98d9066db749df5880275e647ed36dabb2862081b1d787952e1100 (KEY)0072945020150000524756600427endosymbioticoriginanddifferentiallossofeukaryotic DE-627 ger DE-627 rakwb eng 070 500 DNB 500 AVZ BIODIV fid Mayo Roettger verfasserin aut Endosymbiotic origin and differential loss of eukaryotic genes 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Chloroplasts arose from cyanobacteria, mitochondria arose from proteobacteria. Both organelles have conserved their prokaryotic biochemistry, but their genomes are reduced, and most organelle proteins are encoded in the nucleus. Endosymbiotic theory posits that bacterial genes in eukaryotic genomes entered the eukaryotic lineage via organelle ancestors. It predicts episodic influx of prokaryotic genes into the eukaryotic lineage, with acquisition corresponding to endosymbiotic events. Eukaryotic genome sequences, however, increasingly implicate lateral gene transfer, both from prokaryotes to eukaryotes and among eukaryotes, as a source of gene content variation in eukaryotic genomes, which predicts continuous, lineage-specific acquisition of prokaryotic genes in divergent eukaryotic groups. Here we discriminate between these two alternatives by clustering and phylogenetic analysis of eukaryotic gene families having prokaryotic homologues. Our results indicate (1) that gene transfer from bacteria to eukaryotes is episodic, as revealed by gene distributions, and coincides with major evolutionary transitions at the origin of chloroplasts and mitochondria; (2) that gene inheritance in eukaryotes is vertical, as revealed by extensive topological comparison, sparse gene distributions stemming from differential loss; and (3) that continuous, lineage-specific lateral gene transfer, although it sometimes occurs, does not contribute to long-term gene content evolution in eukaryotic genomes. Eukaryotes Genes Evolution Phylogenetics Eukaryota - classification Archaea - genetics Gene Transfer, Horizontal - genetics Organelles - genetics Genome - genetics Prokaryotic Cells - metabolism Eukaryotic Cells - metabolism Mitochondria - genetics Symbiosis - genetics Plastids - genetics Bacteria - genetics Eukaryota - genetics Proteome - genetics Genetic research Research Genetic transformation Genetic aspects Einat Hazkani-Covo oth Giddy Landan oth Shijulal Nelson-Sathi oth Chuan Ku oth David Bryant oth William F Martin oth Filipa L Sousa oth Peter J Lockhart oth James O Mcinerney oth Enthalten in Nature London : Macmillan Publishers Limited, part of Springer Nature, 1869 524(2015), 7566, Seite 427-432 (DE-627)129292834 (DE-600)120714-3 (DE-576)014473941 0028-0836 nnns volume:524 year:2015 number:7566 pages:427-432 http://dx.doi.org/10.1038/nature14963 Volltext http://www.ncbi.nlm.nih.gov/pubmed/26287458 http://search.proquest.com/docview/1708884522 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_30 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_100 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_154 GBV_ILN_160 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_267 GBV_ILN_290 GBV_ILN_294 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2015 GBV_ILN_2016 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2095 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4700 AR 524 2015 7566 427-432
language	English
source	Enthalten in Nature 524(2015), 7566, Seite 427-432 volume:524 year:2015 number:7566 pages:427-432
sourceStr	Enthalten in Nature 524(2015), 7566, Seite 427-432 volume:524 year:2015 number:7566 pages:427-432
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Eukaryotes Genes Evolution Phylogenetics Eukaryota - classification Archaea - genetics Gene Transfer, Horizontal - genetics Organelles - genetics Genome - genetics Prokaryotic Cells - metabolism Eukaryotic Cells - metabolism Mitochondria - genetics Symbiosis - genetics Plastids - genetics Bacteria - genetics Eukaryota - genetics Proteome - genetics Genetic research Research Genetic transformation Genetic aspects
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container_title	Nature
authorswithroles_txt_mv	Mayo Roettger @@aut@@ Einat Hazkani-Covo @@oth@@ Giddy Landan @@oth@@ Shijulal Nelson-Sathi @@oth@@ Chuan Ku @@oth@@ David Bryant @@oth@@ William F Martin @@oth@@ Filipa L Sousa @@oth@@ Peter J Lockhart @@oth@@ James O Mcinerney @@oth@@
publishDateDaySort_date	2015-01-01T00:00:00Z
hierarchy_top_id	129292834
dewey-sort	270
id	OLC196966374X
language_de	englisch
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author	Mayo Roettger
spellingShingle	Mayo Roettger ddc 070 ddc 500 fid BIODIV misc Eukaryotes misc Genes misc Evolution misc Phylogenetics misc Eukaryota - classification misc Archaea - genetics misc Gene Transfer, Horizontal - genetics misc Organelles - genetics misc Genome - genetics misc Prokaryotic Cells - metabolism misc Eukaryotic Cells - metabolism misc Mitochondria - genetics misc Symbiosis - genetics misc Plastids - genetics misc Bacteria - genetics misc Eukaryota - genetics misc Proteome - genetics misc Genetic research misc Research misc Genetic transformation misc Genetic aspects Endosymbiotic origin and differential loss of eukaryotic genes
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topic_title	070 500 DNB 500 AVZ BIODIV fid Endosymbiotic origin and differential loss of eukaryotic genes Eukaryotes Genes Evolution Phylogenetics Eukaryota - classification Archaea - genetics Gene Transfer, Horizontal - genetics Organelles - genetics Genome - genetics Prokaryotic Cells - metabolism Eukaryotic Cells - metabolism Mitochondria - genetics Symbiosis - genetics Plastids - genetics Bacteria - genetics Eukaryota - genetics Proteome - genetics Genetic research Research Genetic transformation Genetic aspects
topic	ddc 070 ddc 500 fid BIODIV misc Eukaryotes misc Genes misc Evolution misc Phylogenetics misc Eukaryota - classification misc Archaea - genetics misc Gene Transfer, Horizontal - genetics misc Organelles - genetics misc Genome - genetics misc Prokaryotic Cells - metabolism misc Eukaryotic Cells - metabolism misc Mitochondria - genetics misc Symbiosis - genetics misc Plastids - genetics misc Bacteria - genetics misc Eukaryota - genetics misc Proteome - genetics misc Genetic research misc Research misc Genetic transformation misc Genetic aspects
topic_unstemmed	ddc 070 ddc 500 fid BIODIV misc Eukaryotes misc Genes misc Evolution misc Phylogenetics misc Eukaryota - classification misc Archaea - genetics misc Gene Transfer, Horizontal - genetics misc Organelles - genetics misc Genome - genetics misc Prokaryotic Cells - metabolism misc Eukaryotic Cells - metabolism misc Mitochondria - genetics misc Symbiosis - genetics misc Plastids - genetics misc Bacteria - genetics misc Eukaryota - genetics misc Proteome - genetics misc Genetic research misc Research misc Genetic transformation misc Genetic aspects
topic_browse	ddc 070 ddc 500 fid BIODIV misc Eukaryotes misc Genes misc Evolution misc Phylogenetics misc Eukaryota - classification misc Archaea - genetics misc Gene Transfer, Horizontal - genetics misc Organelles - genetics misc Genome - genetics misc Prokaryotic Cells - metabolism misc Eukaryotic Cells - metabolism misc Mitochondria - genetics misc Symbiosis - genetics misc Plastids - genetics misc Bacteria - genetics misc Eukaryota - genetics misc Proteome - genetics misc Genetic research misc Research misc Genetic transformation misc Genetic aspects
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title	Endosymbiotic origin and differential loss of eukaryotic genes
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title_full	Endosymbiotic origin and differential loss of eukaryotic genes
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title_sort	endosymbiotic origin and differential loss of eukaryotic genes
title_auth	Endosymbiotic origin and differential loss of eukaryotic genes
abstract	Chloroplasts arose from cyanobacteria, mitochondria arose from proteobacteria. Both organelles have conserved their prokaryotic biochemistry, but their genomes are reduced, and most organelle proteins are encoded in the nucleus. Endosymbiotic theory posits that bacterial genes in eukaryotic genomes entered the eukaryotic lineage via organelle ancestors. It predicts episodic influx of prokaryotic genes into the eukaryotic lineage, with acquisition corresponding to endosymbiotic events. Eukaryotic genome sequences, however, increasingly implicate lateral gene transfer, both from prokaryotes to eukaryotes and among eukaryotes, as a source of gene content variation in eukaryotic genomes, which predicts continuous, lineage-specific acquisition of prokaryotic genes in divergent eukaryotic groups. Here we discriminate between these two alternatives by clustering and phylogenetic analysis of eukaryotic gene families having prokaryotic homologues. Our results indicate (1) that gene transfer from bacteria to eukaryotes is episodic, as revealed by gene distributions, and coincides with major evolutionary transitions at the origin of chloroplasts and mitochondria; (2) that gene inheritance in eukaryotes is vertical, as revealed by extensive topological comparison, sparse gene distributions stemming from differential loss; and (3) that continuous, lineage-specific lateral gene transfer, although it sometimes occurs, does not contribute to long-term gene content evolution in eukaryotic genomes.
abstractGer	Chloroplasts arose from cyanobacteria, mitochondria arose from proteobacteria. Both organelles have conserved their prokaryotic biochemistry, but their genomes are reduced, and most organelle proteins are encoded in the nucleus. Endosymbiotic theory posits that bacterial genes in eukaryotic genomes entered the eukaryotic lineage via organelle ancestors. It predicts episodic influx of prokaryotic genes into the eukaryotic lineage, with acquisition corresponding to endosymbiotic events. Eukaryotic genome sequences, however, increasingly implicate lateral gene transfer, both from prokaryotes to eukaryotes and among eukaryotes, as a source of gene content variation in eukaryotic genomes, which predicts continuous, lineage-specific acquisition of prokaryotic genes in divergent eukaryotic groups. Here we discriminate between these two alternatives by clustering and phylogenetic analysis of eukaryotic gene families having prokaryotic homologues. Our results indicate (1) that gene transfer from bacteria to eukaryotes is episodic, as revealed by gene distributions, and coincides with major evolutionary transitions at the origin of chloroplasts and mitochondria; (2) that gene inheritance in eukaryotes is vertical, as revealed by extensive topological comparison, sparse gene distributions stemming from differential loss; and (3) that continuous, lineage-specific lateral gene transfer, although it sometimes occurs, does not contribute to long-term gene content evolution in eukaryotic genomes.
abstract_unstemmed	Chloroplasts arose from cyanobacteria, mitochondria arose from proteobacteria. Both organelles have conserved their prokaryotic biochemistry, but their genomes are reduced, and most organelle proteins are encoded in the nucleus. Endosymbiotic theory posits that bacterial genes in eukaryotic genomes entered the eukaryotic lineage via organelle ancestors. It predicts episodic influx of prokaryotic genes into the eukaryotic lineage, with acquisition corresponding to endosymbiotic events. Eukaryotic genome sequences, however, increasingly implicate lateral gene transfer, both from prokaryotes to eukaryotes and among eukaryotes, as a source of gene content variation in eukaryotic genomes, which predicts continuous, lineage-specific acquisition of prokaryotic genes in divergent eukaryotic groups. Here we discriminate between these two alternatives by clustering and phylogenetic analysis of eukaryotic gene families having prokaryotic homologues. Our results indicate (1) that gene transfer from bacteria to eukaryotes is episodic, as revealed by gene distributions, and coincides with major evolutionary transitions at the origin of chloroplasts and mitochondria; (2) that gene inheritance in eukaryotes is vertical, as revealed by extensive topological comparison, sparse gene distributions stemming from differential loss; and (3) that continuous, lineage-specific lateral gene transfer, although it sometimes occurs, does not contribute to long-term gene content evolution in eukaryotic genomes.
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container_issue	7566
title_short	Endosymbiotic origin and differential loss of eukaryotic genes
url	http://dx.doi.org/10.1038/nature14963 http://www.ncbi.nlm.nih.gov/pubmed/26287458 http://search.proquest.com/docview/1708884522
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