A sexually dimorphic hypothalamic circuit controls maternal care and oxytocin secretion

It is commonly assumed, but has rarely been demonstrated, that sex differences in behaviour arise from sexual dimorphism in the underlying neural circuits. Parental care is a complex stereotypic behaviour towards offspring that is shared by numerous species. Mice display profound sex differences in...
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Autor*in:	Niv Scott [verfasserIn] Tali Kimchi Matthias Prigge Ofer Yizhar

Format:	Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Dopamine Mothers Neurons Brain Enzymes Animal reproduction Females Gender differences Animal behavior Anterior Hypothalamic Nucleus - cytology Anterior Hypothalamic Nucleus - physiology Hypothalamus - cytology Hypothalamus - enzymology Oxytocin - secretion Tyrosine 3-Monooxygenase - metabolism Synapses - metabolism Paraventricular Hypothalamic Nucleus - enzymology Dopaminergic Neurons - metabolism Oxytocin - blood Maternal Behavior - physiology Paraventricular Hypothalamic Nucleus - physiology Dopaminergic Neurons - enzymology Paraventricular Hypothalamic Nucleus - cytology Hypothalamus - physiology Anterior Hypothalamic Nucleus - enzymology

Übergeordnetes Werk:	Enthalten in: Nature - London : Macmillan Publishers Limited, part of Springer Nature, 1869, 525(2015), 7570, Seite 519
Übergeordnetes Werk:	volume:525 ; year:2015 ; number:7570 ; pages:519

Links:	Link aufrufen Link aufrufen

Katalog-ID:	OLC1969669101

Internformat


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520			\|a It is commonly assumed, but has rarely been demonstrated, that sex differences in behaviour arise from sexual dimorphism in the underlying neural circuits. Parental care is a complex stereotypic behaviour towards offspring that is shared by numerous species. Mice display profound sex differences in offspring-directed behaviours. At their first encounter, virgin females behave maternally towards alien pups while males will usually ignore the pups or attack them. Here we show that tyrosine hydroxylase (TH)-expressing neurons in the anteroventral periventricular nucleus (AVPV) of themouse hypothalamus are more numerous in mothers than in virgin females and males, and govern parental behaviours in a sex-specific manner. In females, ablating the AVPV TH^sup +^ neurons impairs maternal behaviour whereas optogenetic stimulation or increased TH expression in these cells enhancematernal care. In males, however, this same neuronal cluster has no effect on parental care but rather suppresses intermale aggression. Furthermore, optogenetic activation or increased TH expression in the AVPV TH^sup +^ neurons of female mice increases circulating oxytocin, whereas their ablation reduces oxytocin levels. Finally, we show that AVPV TH^sup +^ neurons relay a monosynaptic input to oxytocin-expressing neurons in the paraventricular nucleus. Our findings uncover a previously unknown role for this neuronal population in the control of maternal care and oxytocin secretion, and provide evidence for a causal relationship between sexual dimorphism in the adult brain and sex differences in parental behaviour.
650		4	\|a Dopamine
650		4	\|a Mothers
650		4	\|a Neurons
650		4	\|a Brain
650		4	\|a Enzymes
650		4	\|a Animal reproduction
650		4	\|a Females
650		4	\|a Gender differences
650		4	\|a Animal behavior
650		4	\|a Anterior Hypothalamic Nucleus - cytology
650		4	\|a Anterior Hypothalamic Nucleus - physiology
650		4	\|a Hypothalamus - cytology
650		4	\|a Hypothalamus - enzymology
650		4	\|a Oxytocin - secretion
650		4	\|a Tyrosine 3-Monooxygenase - metabolism
650		4	\|a Synapses - metabolism
650		4	\|a Paraventricular Hypothalamic Nucleus - enzymology
650		4	\|a Dopaminergic Neurons - metabolism
650		4	\|a Oxytocin - blood
650		4	\|a Maternal Behavior - physiology
650		4	\|a Paraventricular Hypothalamic Nucleus - physiology
650		4	\|a Dopaminergic Neurons - enzymology
650		4	\|a Paraventricular Hypothalamic Nucleus - cytology
650		4	\|a Hypothalamus - physiology
650		4	\|a Anterior Hypothalamic Nucleus - enzymology
700	0		\|a Tali Kimchi \|4 oth
700	0		\|a Matthias Prigge \|4 oth
700	0		\|a Ofer Yizhar \|4 oth
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allfields	PQ20160211 (DE-627)OLC1969669101 (DE-599)GBVOLC1969669101 (PRQ)p1272-2459037a5e1a36a003c889870b659f922e44158b64454f104255fb6ea12162780 (KEY)0072945020150000525757000519sexuallydimorphichypothalamiccircuitcontrolsmatern DE-627 ger DE-627 rakwb eng 070 500 DNB 500 AVZ BIODIV fid Niv Scott verfasserin aut A sexually dimorphic hypothalamic circuit controls maternal care and oxytocin secretion 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier It is commonly assumed, but has rarely been demonstrated, that sex differences in behaviour arise from sexual dimorphism in the underlying neural circuits. Parental care is a complex stereotypic behaviour towards offspring that is shared by numerous species. Mice display profound sex differences in offspring-directed behaviours. At their first encounter, virgin females behave maternally towards alien pups while males will usually ignore the pups or attack them. Here we show that tyrosine hydroxylase (TH)-expressing neurons in the anteroventral periventricular nucleus (AVPV) of themouse hypothalamus are more numerous in mothers than in virgin females and males, and govern parental behaviours in a sex-specific manner. In females, ablating the AVPV TH^sup +^ neurons impairs maternal behaviour whereas optogenetic stimulation or increased TH expression in these cells enhancematernal care. In males, however, this same neuronal cluster has no effect on parental care but rather suppresses intermale aggression. Furthermore, optogenetic activation or increased TH expression in the AVPV TH^sup +^ neurons of female mice increases circulating oxytocin, whereas their ablation reduces oxytocin levels. Finally, we show that AVPV TH^sup +^ neurons relay a monosynaptic input to oxytocin-expressing neurons in the paraventricular nucleus. Our findings uncover a previously unknown role for this neuronal population in the control of maternal care and oxytocin secretion, and provide evidence for a causal relationship between sexual dimorphism in the adult brain and sex differences in parental behaviour. Dopamine Mothers Neurons Brain Enzymes Animal reproduction Females Gender differences Animal behavior Anterior Hypothalamic Nucleus - cytology Anterior Hypothalamic Nucleus - physiology Hypothalamus - cytology Hypothalamus - enzymology Oxytocin - secretion Tyrosine 3-Monooxygenase - metabolism Synapses - metabolism Paraventricular Hypothalamic Nucleus - enzymology Dopaminergic Neurons - metabolism Oxytocin - blood Maternal Behavior - physiology Paraventricular Hypothalamic Nucleus - physiology Dopaminergic Neurons - enzymology Paraventricular Hypothalamic Nucleus - cytology Hypothalamus - physiology Anterior Hypothalamic Nucleus - enzymology Tali Kimchi oth Matthias Prigge oth Ofer Yizhar oth Enthalten in Nature London : Macmillan Publishers Limited, part of Springer Nature, 1869 525(2015), 7570, Seite 519 (DE-627)129292834 (DE-600)120714-3 (DE-576)014473941 0028-0836 nnns volume:525 year:2015 number:7570 pages:519 http://www.ncbi.nlm.nih.gov/pubmed/26375004 http://search.proquest.com/docview/1717432563 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_30 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_100 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_154 GBV_ILN_160 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_267 GBV_ILN_290 GBV_ILN_294 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2015 GBV_ILN_2016 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2095 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4700 AR 525 2015 7570 519
spelling	PQ20160211 (DE-627)OLC1969669101 (DE-599)GBVOLC1969669101 (PRQ)p1272-2459037a5e1a36a003c889870b659f922e44158b64454f104255fb6ea12162780 (KEY)0072945020150000525757000519sexuallydimorphichypothalamiccircuitcontrolsmatern DE-627 ger DE-627 rakwb eng 070 500 DNB 500 AVZ BIODIV fid Niv Scott verfasserin aut A sexually dimorphic hypothalamic circuit controls maternal care and oxytocin secretion 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier It is commonly assumed, but has rarely been demonstrated, that sex differences in behaviour arise from sexual dimorphism in the underlying neural circuits. Parental care is a complex stereotypic behaviour towards offspring that is shared by numerous species. Mice display profound sex differences in offspring-directed behaviours. At their first encounter, virgin females behave maternally towards alien pups while males will usually ignore the pups or attack them. Here we show that tyrosine hydroxylase (TH)-expressing neurons in the anteroventral periventricular nucleus (AVPV) of themouse hypothalamus are more numerous in mothers than in virgin females and males, and govern parental behaviours in a sex-specific manner. In females, ablating the AVPV TH^sup +^ neurons impairs maternal behaviour whereas optogenetic stimulation or increased TH expression in these cells enhancematernal care. In males, however, this same neuronal cluster has no effect on parental care but rather suppresses intermale aggression. Furthermore, optogenetic activation or increased TH expression in the AVPV TH^sup +^ neurons of female mice increases circulating oxytocin, whereas their ablation reduces oxytocin levels. Finally, we show that AVPV TH^sup +^ neurons relay a monosynaptic input to oxytocin-expressing neurons in the paraventricular nucleus. Our findings uncover a previously unknown role for this neuronal population in the control of maternal care and oxytocin secretion, and provide evidence for a causal relationship between sexual dimorphism in the adult brain and sex differences in parental behaviour. Dopamine Mothers Neurons Brain Enzymes Animal reproduction Females Gender differences Animal behavior Anterior Hypothalamic Nucleus - cytology Anterior Hypothalamic Nucleus - physiology Hypothalamus - cytology Hypothalamus - enzymology Oxytocin - secretion Tyrosine 3-Monooxygenase - metabolism Synapses - metabolism Paraventricular Hypothalamic Nucleus - enzymology Dopaminergic Neurons - metabolism Oxytocin - blood Maternal Behavior - physiology Paraventricular Hypothalamic Nucleus - physiology Dopaminergic Neurons - enzymology Paraventricular Hypothalamic Nucleus - cytology Hypothalamus - physiology Anterior Hypothalamic Nucleus - enzymology Tali Kimchi oth Matthias Prigge oth Ofer Yizhar oth Enthalten in Nature London : Macmillan Publishers Limited, part of Springer Nature, 1869 525(2015), 7570, Seite 519 (DE-627)129292834 (DE-600)120714-3 (DE-576)014473941 0028-0836 nnns volume:525 year:2015 number:7570 pages:519 http://www.ncbi.nlm.nih.gov/pubmed/26375004 http://search.proquest.com/docview/1717432563 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_30 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_100 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_154 GBV_ILN_160 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_267 GBV_ILN_290 GBV_ILN_294 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2015 GBV_ILN_2016 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2095 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4700 AR 525 2015 7570 519
allfields_unstemmed	PQ20160211 (DE-627)OLC1969669101 (DE-599)GBVOLC1969669101 (PRQ)p1272-2459037a5e1a36a003c889870b659f922e44158b64454f104255fb6ea12162780 (KEY)0072945020150000525757000519sexuallydimorphichypothalamiccircuitcontrolsmatern DE-627 ger DE-627 rakwb eng 070 500 DNB 500 AVZ BIODIV fid Niv Scott verfasserin aut A sexually dimorphic hypothalamic circuit controls maternal care and oxytocin secretion 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier It is commonly assumed, but has rarely been demonstrated, that sex differences in behaviour arise from sexual dimorphism in the underlying neural circuits. Parental care is a complex stereotypic behaviour towards offspring that is shared by numerous species. Mice display profound sex differences in offspring-directed behaviours. At their first encounter, virgin females behave maternally towards alien pups while males will usually ignore the pups or attack them. Here we show that tyrosine hydroxylase (TH)-expressing neurons in the anteroventral periventricular nucleus (AVPV) of themouse hypothalamus are more numerous in mothers than in virgin females and males, and govern parental behaviours in a sex-specific manner. In females, ablating the AVPV TH^sup +^ neurons impairs maternal behaviour whereas optogenetic stimulation or increased TH expression in these cells enhancematernal care. In males, however, this same neuronal cluster has no effect on parental care but rather suppresses intermale aggression. Furthermore, optogenetic activation or increased TH expression in the AVPV TH^sup +^ neurons of female mice increases circulating oxytocin, whereas their ablation reduces oxytocin levels. Finally, we show that AVPV TH^sup +^ neurons relay a monosynaptic input to oxytocin-expressing neurons in the paraventricular nucleus. Our findings uncover a previously unknown role for this neuronal population in the control of maternal care and oxytocin secretion, and provide evidence for a causal relationship between sexual dimorphism in the adult brain and sex differences in parental behaviour. Dopamine Mothers Neurons Brain Enzymes Animal reproduction Females Gender differences Animal behavior Anterior Hypothalamic Nucleus - cytology Anterior Hypothalamic Nucleus - physiology Hypothalamus - cytology Hypothalamus - enzymology Oxytocin - secretion Tyrosine 3-Monooxygenase - metabolism Synapses - metabolism Paraventricular Hypothalamic Nucleus - enzymology Dopaminergic Neurons - metabolism Oxytocin - blood Maternal Behavior - physiology Paraventricular Hypothalamic Nucleus - physiology Dopaminergic Neurons - enzymology Paraventricular Hypothalamic Nucleus - cytology Hypothalamus - physiology Anterior Hypothalamic Nucleus - enzymology Tali Kimchi oth Matthias Prigge oth Ofer Yizhar oth Enthalten in Nature London : Macmillan Publishers Limited, part of Springer Nature, 1869 525(2015), 7570, Seite 519 (DE-627)129292834 (DE-600)120714-3 (DE-576)014473941 0028-0836 nnns volume:525 year:2015 number:7570 pages:519 http://www.ncbi.nlm.nih.gov/pubmed/26375004 http://search.proquest.com/docview/1717432563 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_30 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_100 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_154 GBV_ILN_160 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_267 GBV_ILN_290 GBV_ILN_294 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2015 GBV_ILN_2016 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2095 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4700 AR 525 2015 7570 519
allfieldsGer	PQ20160211 (DE-627)OLC1969669101 (DE-599)GBVOLC1969669101 (PRQ)p1272-2459037a5e1a36a003c889870b659f922e44158b64454f104255fb6ea12162780 (KEY)0072945020150000525757000519sexuallydimorphichypothalamiccircuitcontrolsmatern DE-627 ger DE-627 rakwb eng 070 500 DNB 500 AVZ BIODIV fid Niv Scott verfasserin aut A sexually dimorphic hypothalamic circuit controls maternal care and oxytocin secretion 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier It is commonly assumed, but has rarely been demonstrated, that sex differences in behaviour arise from sexual dimorphism in the underlying neural circuits. Parental care is a complex stereotypic behaviour towards offspring that is shared by numerous species. Mice display profound sex differences in offspring-directed behaviours. At their first encounter, virgin females behave maternally towards alien pups while males will usually ignore the pups or attack them. Here we show that tyrosine hydroxylase (TH)-expressing neurons in the anteroventral periventricular nucleus (AVPV) of themouse hypothalamus are more numerous in mothers than in virgin females and males, and govern parental behaviours in a sex-specific manner. In females, ablating the AVPV TH^sup +^ neurons impairs maternal behaviour whereas optogenetic stimulation or increased TH expression in these cells enhancematernal care. In males, however, this same neuronal cluster has no effect on parental care but rather suppresses intermale aggression. Furthermore, optogenetic activation or increased TH expression in the AVPV TH^sup +^ neurons of female mice increases circulating oxytocin, whereas their ablation reduces oxytocin levels. Finally, we show that AVPV TH^sup +^ neurons relay a monosynaptic input to oxytocin-expressing neurons in the paraventricular nucleus. Our findings uncover a previously unknown role for this neuronal population in the control of maternal care and oxytocin secretion, and provide evidence for a causal relationship between sexual dimorphism in the adult brain and sex differences in parental behaviour. Dopamine Mothers Neurons Brain Enzymes Animal reproduction Females Gender differences Animal behavior Anterior Hypothalamic Nucleus - cytology Anterior Hypothalamic Nucleus - physiology Hypothalamus - cytology Hypothalamus - enzymology Oxytocin - secretion Tyrosine 3-Monooxygenase - metabolism Synapses - metabolism Paraventricular Hypothalamic Nucleus - enzymology Dopaminergic Neurons - metabolism Oxytocin - blood Maternal Behavior - physiology Paraventricular Hypothalamic Nucleus - physiology Dopaminergic Neurons - enzymology Paraventricular Hypothalamic Nucleus - cytology Hypothalamus - physiology Anterior Hypothalamic Nucleus - enzymology Tali Kimchi oth Matthias Prigge oth Ofer Yizhar oth Enthalten in Nature London : Macmillan Publishers Limited, part of Springer Nature, 1869 525(2015), 7570, Seite 519 (DE-627)129292834 (DE-600)120714-3 (DE-576)014473941 0028-0836 nnns volume:525 year:2015 number:7570 pages:519 http://www.ncbi.nlm.nih.gov/pubmed/26375004 http://search.proquest.com/docview/1717432563 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_30 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_100 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_154 GBV_ILN_160 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_267 GBV_ILN_290 GBV_ILN_294 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2015 GBV_ILN_2016 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2095 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4700 AR 525 2015 7570 519
allfieldsSound	PQ20160211 (DE-627)OLC1969669101 (DE-599)GBVOLC1969669101 (PRQ)p1272-2459037a5e1a36a003c889870b659f922e44158b64454f104255fb6ea12162780 (KEY)0072945020150000525757000519sexuallydimorphichypothalamiccircuitcontrolsmatern DE-627 ger DE-627 rakwb eng 070 500 DNB 500 AVZ BIODIV fid Niv Scott verfasserin aut A sexually dimorphic hypothalamic circuit controls maternal care and oxytocin secretion 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier It is commonly assumed, but has rarely been demonstrated, that sex differences in behaviour arise from sexual dimorphism in the underlying neural circuits. Parental care is a complex stereotypic behaviour towards offspring that is shared by numerous species. Mice display profound sex differences in offspring-directed behaviours. At their first encounter, virgin females behave maternally towards alien pups while males will usually ignore the pups or attack them. Here we show that tyrosine hydroxylase (TH)-expressing neurons in the anteroventral periventricular nucleus (AVPV) of themouse hypothalamus are more numerous in mothers than in virgin females and males, and govern parental behaviours in a sex-specific manner. In females, ablating the AVPV TH^sup +^ neurons impairs maternal behaviour whereas optogenetic stimulation or increased TH expression in these cells enhancematernal care. In males, however, this same neuronal cluster has no effect on parental care but rather suppresses intermale aggression. Furthermore, optogenetic activation or increased TH expression in the AVPV TH^sup +^ neurons of female mice increases circulating oxytocin, whereas their ablation reduces oxytocin levels. Finally, we show that AVPV TH^sup +^ neurons relay a monosynaptic input to oxytocin-expressing neurons in the paraventricular nucleus. Our findings uncover a previously unknown role for this neuronal population in the control of maternal care and oxytocin secretion, and provide evidence for a causal relationship between sexual dimorphism in the adult brain and sex differences in parental behaviour. Dopamine Mothers Neurons Brain Enzymes Animal reproduction Females Gender differences Animal behavior Anterior Hypothalamic Nucleus - cytology Anterior Hypothalamic Nucleus - physiology Hypothalamus - cytology Hypothalamus - enzymology Oxytocin - secretion Tyrosine 3-Monooxygenase - metabolism Synapses - metabolism Paraventricular Hypothalamic Nucleus - enzymology Dopaminergic Neurons - metabolism Oxytocin - blood Maternal Behavior - physiology Paraventricular Hypothalamic Nucleus - physiology Dopaminergic Neurons - enzymology Paraventricular Hypothalamic Nucleus - cytology Hypothalamus - physiology Anterior Hypothalamic Nucleus - enzymology Tali Kimchi oth Matthias Prigge oth Ofer Yizhar oth Enthalten in Nature London : Macmillan Publishers Limited, part of Springer Nature, 1869 525(2015), 7570, Seite 519 (DE-627)129292834 (DE-600)120714-3 (DE-576)014473941 0028-0836 nnns volume:525 year:2015 number:7570 pages:519 http://www.ncbi.nlm.nih.gov/pubmed/26375004 http://search.proquest.com/docview/1717432563 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_21 GBV_ILN_22 GBV_ILN_30 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_100 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_154 GBV_ILN_160 GBV_ILN_168 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_267 GBV_ILN_290 GBV_ILN_294 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2015 GBV_ILN_2016 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2095 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4046 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4313 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4320 GBV_ILN_4324 GBV_ILN_4700 AR 525 2015 7570 519
language	English
source	Enthalten in Nature 525(2015), 7570, Seite 519 volume:525 year:2015 number:7570 pages:519
sourceStr	Enthalten in Nature 525(2015), 7570, Seite 519 volume:525 year:2015 number:7570 pages:519
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Dopamine Mothers Neurons Brain Enzymes Animal reproduction Females Gender differences Animal behavior Anterior Hypothalamic Nucleus - cytology Anterior Hypothalamic Nucleus - physiology Hypothalamus - cytology Hypothalamus - enzymology Oxytocin - secretion Tyrosine 3-Monooxygenase - metabolism Synapses - metabolism Paraventricular Hypothalamic Nucleus - enzymology Dopaminergic Neurons - metabolism Oxytocin - blood Maternal Behavior - physiology Paraventricular Hypothalamic Nucleus - physiology Dopaminergic Neurons - enzymology Paraventricular Hypothalamic Nucleus - cytology Hypothalamus - physiology Anterior Hypothalamic Nucleus - enzymology
dewey-raw	070
isfreeaccess_bool	false
container_title	Nature
authorswithroles_txt_mv	Niv Scott @@aut@@ Tali Kimchi @@oth@@ Matthias Prigge @@oth@@ Ofer Yizhar @@oth@@
publishDateDaySort_date	2015-01-01T00:00:00Z
hierarchy_top_id	129292834
dewey-sort	270
id	OLC1969669101
language_de	englisch
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author	Niv Scott
spellingShingle	Niv Scott ddc 070 ddc 500 fid BIODIV misc Dopamine misc Mothers misc Neurons misc Brain misc Enzymes misc Animal reproduction misc Females misc Gender differences misc Animal behavior misc Anterior Hypothalamic Nucleus - cytology misc Anterior Hypothalamic Nucleus - physiology misc Hypothalamus - cytology misc Hypothalamus - enzymology misc Oxytocin - secretion misc Tyrosine 3-Monooxygenase - metabolism misc Synapses - metabolism misc Paraventricular Hypothalamic Nucleus - enzymology misc Dopaminergic Neurons - metabolism misc Oxytocin - blood misc Maternal Behavior - physiology misc Paraventricular Hypothalamic Nucleus - physiology misc Dopaminergic Neurons - enzymology misc Paraventricular Hypothalamic Nucleus - cytology misc Hypothalamus - physiology misc Anterior Hypothalamic Nucleus - enzymology A sexually dimorphic hypothalamic circuit controls maternal care and oxytocin secretion
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topic_title	070 500 DNB 500 AVZ BIODIV fid A sexually dimorphic hypothalamic circuit controls maternal care and oxytocin secretion Dopamine Mothers Neurons Brain Enzymes Animal reproduction Females Gender differences Animal behavior Anterior Hypothalamic Nucleus - cytology Anterior Hypothalamic Nucleus - physiology Hypothalamus - cytology Hypothalamus - enzymology Oxytocin - secretion Tyrosine 3-Monooxygenase - metabolism Synapses - metabolism Paraventricular Hypothalamic Nucleus - enzymology Dopaminergic Neurons - metabolism Oxytocin - blood Maternal Behavior - physiology Paraventricular Hypothalamic Nucleus - physiology Dopaminergic Neurons - enzymology Paraventricular Hypothalamic Nucleus - cytology Hypothalamus - physiology Anterior Hypothalamic Nucleus - enzymology
topic	ddc 070 ddc 500 fid BIODIV misc Dopamine misc Mothers misc Neurons misc Brain misc Enzymes misc Animal reproduction misc Females misc Gender differences misc Animal behavior misc Anterior Hypothalamic Nucleus - cytology misc Anterior Hypothalamic Nucleus - physiology misc Hypothalamus - cytology misc Hypothalamus - enzymology misc Oxytocin - secretion misc Tyrosine 3-Monooxygenase - metabolism misc Synapses - metabolism misc Paraventricular Hypothalamic Nucleus - enzymology misc Dopaminergic Neurons - metabolism misc Oxytocin - blood misc Maternal Behavior - physiology misc Paraventricular Hypothalamic Nucleus - physiology misc Dopaminergic Neurons - enzymology misc Paraventricular Hypothalamic Nucleus - cytology misc Hypothalamus - physiology misc Anterior Hypothalamic Nucleus - enzymology
topic_unstemmed	ddc 070 ddc 500 fid BIODIV misc Dopamine misc Mothers misc Neurons misc Brain misc Enzymes misc Animal reproduction misc Females misc Gender differences misc Animal behavior misc Anterior Hypothalamic Nucleus - cytology misc Anterior Hypothalamic Nucleus - physiology misc Hypothalamus - cytology misc Hypothalamus - enzymology misc Oxytocin - secretion misc Tyrosine 3-Monooxygenase - metabolism misc Synapses - metabolism misc Paraventricular Hypothalamic Nucleus - enzymology misc Dopaminergic Neurons - metabolism misc Oxytocin - blood misc Maternal Behavior - physiology misc Paraventricular Hypothalamic Nucleus - physiology misc Dopaminergic Neurons - enzymology misc Paraventricular Hypothalamic Nucleus - cytology misc Hypothalamus - physiology misc Anterior Hypothalamic Nucleus - enzymology
topic_browse	ddc 070 ddc 500 fid BIODIV misc Dopamine misc Mothers misc Neurons misc Brain misc Enzymes misc Animal reproduction misc Females misc Gender differences misc Animal behavior misc Anterior Hypothalamic Nucleus - cytology misc Anterior Hypothalamic Nucleus - physiology misc Hypothalamus - cytology misc Hypothalamus - enzymology misc Oxytocin - secretion misc Tyrosine 3-Monooxygenase - metabolism misc Synapses - metabolism misc Paraventricular Hypothalamic Nucleus - enzymology misc Dopaminergic Neurons - metabolism misc Oxytocin - blood misc Maternal Behavior - physiology misc Paraventricular Hypothalamic Nucleus - physiology misc Dopaminergic Neurons - enzymology misc Paraventricular Hypothalamic Nucleus - cytology misc Hypothalamus - physiology misc Anterior Hypothalamic Nucleus - enzymology
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title	A sexually dimorphic hypothalamic circuit controls maternal care and oxytocin secretion
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title_full	A sexually dimorphic hypothalamic circuit controls maternal care and oxytocin secretion
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title_sort	sexually dimorphic hypothalamic circuit controls maternal care and oxytocin secretion
title_auth	A sexually dimorphic hypothalamic circuit controls maternal care and oxytocin secretion
abstract	It is commonly assumed, but has rarely been demonstrated, that sex differences in behaviour arise from sexual dimorphism in the underlying neural circuits. Parental care is a complex stereotypic behaviour towards offspring that is shared by numerous species. Mice display profound sex differences in offspring-directed behaviours. At their first encounter, virgin females behave maternally towards alien pups while males will usually ignore the pups or attack them. Here we show that tyrosine hydroxylase (TH)-expressing neurons in the anteroventral periventricular nucleus (AVPV) of themouse hypothalamus are more numerous in mothers than in virgin females and males, and govern parental behaviours in a sex-specific manner. In females, ablating the AVPV TH^sup +^ neurons impairs maternal behaviour whereas optogenetic stimulation or increased TH expression in these cells enhancematernal care. In males, however, this same neuronal cluster has no effect on parental care but rather suppresses intermale aggression. Furthermore, optogenetic activation or increased TH expression in the AVPV TH^sup +^ neurons of female mice increases circulating oxytocin, whereas their ablation reduces oxytocin levels. Finally, we show that AVPV TH^sup +^ neurons relay a monosynaptic input to oxytocin-expressing neurons in the paraventricular nucleus. Our findings uncover a previously unknown role for this neuronal population in the control of maternal care and oxytocin secretion, and provide evidence for a causal relationship between sexual dimorphism in the adult brain and sex differences in parental behaviour.
abstractGer	It is commonly assumed, but has rarely been demonstrated, that sex differences in behaviour arise from sexual dimorphism in the underlying neural circuits. Parental care is a complex stereotypic behaviour towards offspring that is shared by numerous species. Mice display profound sex differences in offspring-directed behaviours. At their first encounter, virgin females behave maternally towards alien pups while males will usually ignore the pups or attack them. Here we show that tyrosine hydroxylase (TH)-expressing neurons in the anteroventral periventricular nucleus (AVPV) of themouse hypothalamus are more numerous in mothers than in virgin females and males, and govern parental behaviours in a sex-specific manner. In females, ablating the AVPV TH^sup +^ neurons impairs maternal behaviour whereas optogenetic stimulation or increased TH expression in these cells enhancematernal care. In males, however, this same neuronal cluster has no effect on parental care but rather suppresses intermale aggression. Furthermore, optogenetic activation or increased TH expression in the AVPV TH^sup +^ neurons of female mice increases circulating oxytocin, whereas their ablation reduces oxytocin levels. Finally, we show that AVPV TH^sup +^ neurons relay a monosynaptic input to oxytocin-expressing neurons in the paraventricular nucleus. Our findings uncover a previously unknown role for this neuronal population in the control of maternal care and oxytocin secretion, and provide evidence for a causal relationship between sexual dimorphism in the adult brain and sex differences in parental behaviour.
abstract_unstemmed	It is commonly assumed, but has rarely been demonstrated, that sex differences in behaviour arise from sexual dimorphism in the underlying neural circuits. Parental care is a complex stereotypic behaviour towards offspring that is shared by numerous species. Mice display profound sex differences in offspring-directed behaviours. At their first encounter, virgin females behave maternally towards alien pups while males will usually ignore the pups or attack them. Here we show that tyrosine hydroxylase (TH)-expressing neurons in the anteroventral periventricular nucleus (AVPV) of themouse hypothalamus are more numerous in mothers than in virgin females and males, and govern parental behaviours in a sex-specific manner. In females, ablating the AVPV TH^sup +^ neurons impairs maternal behaviour whereas optogenetic stimulation or increased TH expression in these cells enhancematernal care. In males, however, this same neuronal cluster has no effect on parental care but rather suppresses intermale aggression. Furthermore, optogenetic activation or increased TH expression in the AVPV TH^sup +^ neurons of female mice increases circulating oxytocin, whereas their ablation reduces oxytocin levels. Finally, we show that AVPV TH^sup +^ neurons relay a monosynaptic input to oxytocin-expressing neurons in the paraventricular nucleus. Our findings uncover a previously unknown role for this neuronal population in the control of maternal care and oxytocin secretion, and provide evidence for a causal relationship between sexual dimorphism in the adult brain and sex differences in parental behaviour.
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title_short	A sexually dimorphic hypothalamic circuit controls maternal care and oxytocin secretion
url	http://www.ncbi.nlm.nih.gov/pubmed/26375004 http://search.proquest.com/docview/1717432563
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Parental care is a complex stereotypic behaviour towards offspring that is shared by numerous species. Mice display profound sex differences in offspring-directed behaviours. At their first encounter, virgin females behave maternally towards alien pups while males will usually ignore the pups or attack them. Here we show that tyrosine hydroxylase (TH)-expressing neurons in the anteroventral periventricular nucleus (AVPV) of themouse hypothalamus are more numerous in mothers than in virgin females and males, and govern parental behaviours in a sex-specific manner. In females, ablating the AVPV TH^sup +^ neurons impairs maternal behaviour whereas optogenetic stimulation or increased TH expression in these cells enhancematernal care. In males, however, this same neuronal cluster has no effect on parental care but rather suppresses intermale aggression. Furthermore, optogenetic activation or increased TH expression in the AVPV TH^sup +^ neurons of female mice increases circulating oxytocin, whereas their ablation reduces oxytocin levels. Finally, we show that AVPV TH^sup +^ neurons relay a monosynaptic input to oxytocin-expressing neurons in the paraventricular nucleus. Our findings uncover a previously unknown role for this neuronal population in the control of maternal care and oxytocin secretion, and provide evidence for a causal relationship between sexual dimorphism in the adult brain and sex differences in parental behaviour.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Dopamine</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mothers</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Neurons</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Brain</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Enzymes</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Animal reproduction</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Females</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Gender differences</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Animal behavior</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Anterior Hypothalamic Nucleus - cytology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Anterior Hypothalamic Nucleus - physiology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Hypothalamus - cytology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Hypothalamus - enzymology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Oxytocin - secretion</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Tyrosine 3-Monooxygenase - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Synapses - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Paraventricular Hypothalamic Nucleus - enzymology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Dopaminergic Neurons - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Oxytocin - blood</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Maternal Behavior - physiology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Paraventricular Hypothalamic Nucleus - physiology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Dopaminergic Neurons - enzymology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Paraventricular Hypothalamic Nucleus - cytology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Hypothalamus - physiology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Anterior Hypothalamic Nucleus - enzymology</subfield></datafield><datafield tag="700" ind1="0" ind2=" 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A sexually dimorphic hypothalamic circuit controls maternal care and oxytocin secretion

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