Alternative transcription initiation leads to expression of a novel ALK isoform in cancer

Activation of oncogenes by mechanisms other than genetic aberrations such as mutations, translocations, or amplifications is largely undefined. Here we report a novel isoform of the anaplastic lymphoma kinase (ALK) that is expressed in ~11% of melanomas and sporadically in other human cancer types,...
Ausführliche Beschreibung

Gespeichert in:
Autor*in:

Julia Button [verfasserIn]

James A Fagin

Nathalie Lailler

Leili Ran

Thomas Wiesner

Anna C Obenauf

Zhen Cao

Shipra Shukla

Charlotte E Ariyan

Yu Chen

Marc Ladanyi

Andrea Sboner

Taha Merghoub

Michael F Berger

Rajmohan Murali

William Lee

Laetitia Borsu

Gary K Schwartz

Ronak H Shah

Elissa W P Wong

Qi Fan Zhang

Michael A Postow

Sasinya N Scott

Iñigo Landa

Wenhuo Hu

Deyou Zheng

Travis J Hollmann

Klaus J Busam

Lu Wang

Ping Chi

Devan A Murphy

Dong Gao

Format:

Artikel

Sprache:

Englisch

Erschienen:

2015

Schlagwörter:

Kinases

Genes

Phosphorylation

Cancer therapies

Tumorigenesis

Binding sites

Proteins

Tumors

Thyroid cancer

Metastasis

Melanoma

Oncogenes

Development and progression

Health aspects

Cancer

Genetic transcription

Genetic aspects

Übergeordnetes Werk:

Enthalten in: Nature - London : Macmillan Publishers Limited, part of Springer Nature, 1869, 526(2015), 7573, Seite 453-457

Übergeordnetes Werk:

volume:526 ; year:2015 ; number:7573 ; pages:453-457

Links:

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DOI / URN:

10.1038/nature15258

Katalog-ID:

OLC1969670789

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