Photochemical fate and eco-genotoxicity assessment of the drug etodolac
The photochemical behavior of etodolac was investigated under various irradiation conditions. Kinetic data were obtained after irradiation of 10(-4) M aqueous solutions by UVB, UVA and direct exposure to sunlight. The Xenon lamp irradiation was used in order to determine the photodegradation quantum...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Cermola, Flavio [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Rechteinformationen: |
Nutzungsrecht: Copyright © 2015 Elsevier B.V. All rights reserved. |
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| Schlagwörter: |
Water Pollutants, Chemical - toxicity |
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| Übergeordnetes Werk: |
Enthalten in: The science of the total environment - Amsterdam : Elsevier, 1972, 518-519(2015), Seite 258-265 |
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| Übergeordnetes Werk: |
volume:518-519 ; year:2015 ; pages:258-265 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.scitotenv.2015.03.009 |
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| Katalog-ID: |
OLC1969688823 |
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| 520 | |a The photochemical behavior of etodolac was investigated under various irradiation conditions. Kinetic data were obtained after irradiation of 10(-4) M aqueous solutions by UVB, UVA and direct exposure to sunlight. The Xenon lamp irradiation was used in order to determine the photodegradation quantum yield under sun-simulated condition (ϕsun). The value was determined to be=0.10±0.01. In order to obtain photoproducts and for mechanistic purposes, experiments were carried out on more concentrated solutions by exposure to sunlight and to UVA and UVB lamps. The drug underwent photooxidative processes following an initial oxygen addition to the double bond of the five membered ring and was mainly converted into a spiro compound and a macrolactam. Ecotoxicity tests were performed on etodolac, its photostable spiro derivative and its sunlight irradiation mixture on two different aquatic trophic levels, plants (algae) and invertebrates (rotifers and crustaceans). Mutagenesis and genotoxicity were detected on bacterial strains. The results showed that only etodolac had long term effects on rotifers although at concentrations far from environmental detection values. A mutagenic and genotoxic potential was found for its derivative. | ||
| 540 | |a Nutzungsrecht: Copyright © 2015 Elsevier B.V. All rights reserved. | ||
| 650 | 4 | |a Water Pollutants, Chemical - toxicity | |
| 650 | 4 | |a Etodolac - chemistry | |
| 650 | 4 | |a Water Pollutants, Chemical - chemistry | |
| 650 | 4 | |a Etodolac - toxicity | |
| 700 | 1 | |a Passananti, Monica |4 oth | |
| 700 | 1 | |a Criscuolo, Emma |4 oth | |
| 700 | 1 | |a Brigante, Marcello |4 oth | |
| 700 | 1 | |a DellaGreca, Marina |4 oth | |
| 700 | 1 | |a Lavorgna, Margherita |4 oth | |
| 700 | 1 | |a Isidori, Marina |4 oth | |
| 700 | 1 | |a Iesce, Maria Rosaria |4 oth | |
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10.1016/j.scitotenv.2015.03.009 doi PQ20160211 (DE-627)OLC1969688823 (DE-599)GBVOLC1969688823 (PRQ)c1897-399eff01402a8384aa717c90c89287f92f0f8040b8fea30faa544cf6a42f35bb0 (KEY)0073664320150000518000000258photochemicalfateandecogenotoxicityassessmentofthe DE-627 ger DE-627 rakwb eng 570 333.7 610 DNB Cermola, Flavio verfasserin aut Photochemical fate and eco-genotoxicity assessment of the drug etodolac 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The photochemical behavior of etodolac was investigated under various irradiation conditions. Kinetic data were obtained after irradiation of 10(-4) M aqueous solutions by UVB, UVA and direct exposure to sunlight. The Xenon lamp irradiation was used in order to determine the photodegradation quantum yield under sun-simulated condition (ϕsun). The value was determined to be=0.10±0.01. In order to obtain photoproducts and for mechanistic purposes, experiments were carried out on more concentrated solutions by exposure to sunlight and to UVA and UVB lamps. The drug underwent photooxidative processes following an initial oxygen addition to the double bond of the five membered ring and was mainly converted into a spiro compound and a macrolactam. Ecotoxicity tests were performed on etodolac, its photostable spiro derivative and its sunlight irradiation mixture on two different aquatic trophic levels, plants (algae) and invertebrates (rotifers and crustaceans). Mutagenesis and genotoxicity were detected on bacterial strains. The results showed that only etodolac had long term effects on rotifers although at concentrations far from environmental detection values. A mutagenic and genotoxic potential was found for its derivative. Nutzungsrecht: Copyright © 2015 Elsevier B.V. All rights reserved. Water Pollutants, Chemical - toxicity Etodolac - chemistry Water Pollutants, Chemical - chemistry Etodolac - toxicity Passananti, Monica oth Criscuolo, Emma oth Brigante, Marcello oth DellaGreca, Marina oth Lavorgna, Margherita oth Isidori, Marina oth Iesce, Maria Rosaria oth Enthalten in The science of the total environment Amsterdam : Elsevier, 1972 518-519(2015), Seite 258-265 (DE-627)129297917 (DE-600)121506-1 (DE-576)014490919 0048-9697 nnns volume:518-519 year:2015 pages:258-265 http://dx.doi.org/10.1016/j.scitotenv.2015.03.009 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25765378 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-FOR SSG-OPC-GGO GBV_ILN_21 GBV_ILN_70 GBV_ILN_4012 AR 518-519 2015 258-265 |
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10.1016/j.scitotenv.2015.03.009 doi PQ20160211 (DE-627)OLC1969688823 (DE-599)GBVOLC1969688823 (PRQ)c1897-399eff01402a8384aa717c90c89287f92f0f8040b8fea30faa544cf6a42f35bb0 (KEY)0073664320150000518000000258photochemicalfateandecogenotoxicityassessmentofthe DE-627 ger DE-627 rakwb eng 570 333.7 610 DNB Cermola, Flavio verfasserin aut Photochemical fate and eco-genotoxicity assessment of the drug etodolac 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The photochemical behavior of etodolac was investigated under various irradiation conditions. Kinetic data were obtained after irradiation of 10(-4) M aqueous solutions by UVB, UVA and direct exposure to sunlight. The Xenon lamp irradiation was used in order to determine the photodegradation quantum yield under sun-simulated condition (ϕsun). The value was determined to be=0.10±0.01. In order to obtain photoproducts and for mechanistic purposes, experiments were carried out on more concentrated solutions by exposure to sunlight and to UVA and UVB lamps. The drug underwent photooxidative processes following an initial oxygen addition to the double bond of the five membered ring and was mainly converted into a spiro compound and a macrolactam. Ecotoxicity tests were performed on etodolac, its photostable spiro derivative and its sunlight irradiation mixture on two different aquatic trophic levels, plants (algae) and invertebrates (rotifers and crustaceans). Mutagenesis and genotoxicity were detected on bacterial strains. The results showed that only etodolac had long term effects on rotifers although at concentrations far from environmental detection values. A mutagenic and genotoxic potential was found for its derivative. Nutzungsrecht: Copyright © 2015 Elsevier B.V. All rights reserved. Water Pollutants, Chemical - toxicity Etodolac - chemistry Water Pollutants, Chemical - chemistry Etodolac - toxicity Passananti, Monica oth Criscuolo, Emma oth Brigante, Marcello oth DellaGreca, Marina oth Lavorgna, Margherita oth Isidori, Marina oth Iesce, Maria Rosaria oth Enthalten in The science of the total environment Amsterdam : Elsevier, 1972 518-519(2015), Seite 258-265 (DE-627)129297917 (DE-600)121506-1 (DE-576)014490919 0048-9697 nnns volume:518-519 year:2015 pages:258-265 http://dx.doi.org/10.1016/j.scitotenv.2015.03.009 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25765378 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-FOR SSG-OPC-GGO GBV_ILN_21 GBV_ILN_70 GBV_ILN_4012 AR 518-519 2015 258-265 |
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10.1016/j.scitotenv.2015.03.009 doi PQ20160211 (DE-627)OLC1969688823 (DE-599)GBVOLC1969688823 (PRQ)c1897-399eff01402a8384aa717c90c89287f92f0f8040b8fea30faa544cf6a42f35bb0 (KEY)0073664320150000518000000258photochemicalfateandecogenotoxicityassessmentofthe DE-627 ger DE-627 rakwb eng 570 333.7 610 DNB Cermola, Flavio verfasserin aut Photochemical fate and eco-genotoxicity assessment of the drug etodolac 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The photochemical behavior of etodolac was investigated under various irradiation conditions. Kinetic data were obtained after irradiation of 10(-4) M aqueous solutions by UVB, UVA and direct exposure to sunlight. The Xenon lamp irradiation was used in order to determine the photodegradation quantum yield under sun-simulated condition (ϕsun). The value was determined to be=0.10±0.01. In order to obtain photoproducts and for mechanistic purposes, experiments were carried out on more concentrated solutions by exposure to sunlight and to UVA and UVB lamps. The drug underwent photooxidative processes following an initial oxygen addition to the double bond of the five membered ring and was mainly converted into a spiro compound and a macrolactam. Ecotoxicity tests were performed on etodolac, its photostable spiro derivative and its sunlight irradiation mixture on two different aquatic trophic levels, plants (algae) and invertebrates (rotifers and crustaceans). Mutagenesis and genotoxicity were detected on bacterial strains. The results showed that only etodolac had long term effects on rotifers although at concentrations far from environmental detection values. A mutagenic and genotoxic potential was found for its derivative. Nutzungsrecht: Copyright © 2015 Elsevier B.V. All rights reserved. Water Pollutants, Chemical - toxicity Etodolac - chemistry Water Pollutants, Chemical - chemistry Etodolac - toxicity Passananti, Monica oth Criscuolo, Emma oth Brigante, Marcello oth DellaGreca, Marina oth Lavorgna, Margherita oth Isidori, Marina oth Iesce, Maria Rosaria oth Enthalten in The science of the total environment Amsterdam : Elsevier, 1972 518-519(2015), Seite 258-265 (DE-627)129297917 (DE-600)121506-1 (DE-576)014490919 0048-9697 nnns volume:518-519 year:2015 pages:258-265 http://dx.doi.org/10.1016/j.scitotenv.2015.03.009 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25765378 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-FOR SSG-OPC-GGO GBV_ILN_21 GBV_ILN_70 GBV_ILN_4012 AR 518-519 2015 258-265 |
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10.1016/j.scitotenv.2015.03.009 doi PQ20160211 (DE-627)OLC1969688823 (DE-599)GBVOLC1969688823 (PRQ)c1897-399eff01402a8384aa717c90c89287f92f0f8040b8fea30faa544cf6a42f35bb0 (KEY)0073664320150000518000000258photochemicalfateandecogenotoxicityassessmentofthe DE-627 ger DE-627 rakwb eng 570 333.7 610 DNB Cermola, Flavio verfasserin aut Photochemical fate and eco-genotoxicity assessment of the drug etodolac 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The photochemical behavior of etodolac was investigated under various irradiation conditions. Kinetic data were obtained after irradiation of 10(-4) M aqueous solutions by UVB, UVA and direct exposure to sunlight. The Xenon lamp irradiation was used in order to determine the photodegradation quantum yield under sun-simulated condition (ϕsun). The value was determined to be=0.10±0.01. In order to obtain photoproducts and for mechanistic purposes, experiments were carried out on more concentrated solutions by exposure to sunlight and to UVA and UVB lamps. The drug underwent photooxidative processes following an initial oxygen addition to the double bond of the five membered ring and was mainly converted into a spiro compound and a macrolactam. Ecotoxicity tests were performed on etodolac, its photostable spiro derivative and its sunlight irradiation mixture on two different aquatic trophic levels, plants (algae) and invertebrates (rotifers and crustaceans). Mutagenesis and genotoxicity were detected on bacterial strains. The results showed that only etodolac had long term effects on rotifers although at concentrations far from environmental detection values. A mutagenic and genotoxic potential was found for its derivative. Nutzungsrecht: Copyright © 2015 Elsevier B.V. All rights reserved. Water Pollutants, Chemical - toxicity Etodolac - chemistry Water Pollutants, Chemical - chemistry Etodolac - toxicity Passananti, Monica oth Criscuolo, Emma oth Brigante, Marcello oth DellaGreca, Marina oth Lavorgna, Margherita oth Isidori, Marina oth Iesce, Maria Rosaria oth Enthalten in The science of the total environment Amsterdam : Elsevier, 1972 518-519(2015), Seite 258-265 (DE-627)129297917 (DE-600)121506-1 (DE-576)014490919 0048-9697 nnns volume:518-519 year:2015 pages:258-265 http://dx.doi.org/10.1016/j.scitotenv.2015.03.009 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25765378 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-FOR SSG-OPC-GGO GBV_ILN_21 GBV_ILN_70 GBV_ILN_4012 AR 518-519 2015 258-265 |
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10.1016/j.scitotenv.2015.03.009 doi PQ20160211 (DE-627)OLC1969688823 (DE-599)GBVOLC1969688823 (PRQ)c1897-399eff01402a8384aa717c90c89287f92f0f8040b8fea30faa544cf6a42f35bb0 (KEY)0073664320150000518000000258photochemicalfateandecogenotoxicityassessmentofthe DE-627 ger DE-627 rakwb eng 570 333.7 610 DNB Cermola, Flavio verfasserin aut Photochemical fate and eco-genotoxicity assessment of the drug etodolac 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The photochemical behavior of etodolac was investigated under various irradiation conditions. Kinetic data were obtained after irradiation of 10(-4) M aqueous solutions by UVB, UVA and direct exposure to sunlight. The Xenon lamp irradiation was used in order to determine the photodegradation quantum yield under sun-simulated condition (ϕsun). The value was determined to be=0.10±0.01. In order to obtain photoproducts and for mechanistic purposes, experiments were carried out on more concentrated solutions by exposure to sunlight and to UVA and UVB lamps. The drug underwent photooxidative processes following an initial oxygen addition to the double bond of the five membered ring and was mainly converted into a spiro compound and a macrolactam. Ecotoxicity tests were performed on etodolac, its photostable spiro derivative and its sunlight irradiation mixture on two different aquatic trophic levels, plants (algae) and invertebrates (rotifers and crustaceans). Mutagenesis and genotoxicity were detected on bacterial strains. The results showed that only etodolac had long term effects on rotifers although at concentrations far from environmental detection values. A mutagenic and genotoxic potential was found for its derivative. Nutzungsrecht: Copyright © 2015 Elsevier B.V. All rights reserved. Water Pollutants, Chemical - toxicity Etodolac - chemistry Water Pollutants, Chemical - chemistry Etodolac - toxicity Passananti, Monica oth Criscuolo, Emma oth Brigante, Marcello oth DellaGreca, Marina oth Lavorgna, Margherita oth Isidori, Marina oth Iesce, Maria Rosaria oth Enthalten in The science of the total environment Amsterdam : Elsevier, 1972 518-519(2015), Seite 258-265 (DE-627)129297917 (DE-600)121506-1 (DE-576)014490919 0048-9697 nnns volume:518-519 year:2015 pages:258-265 http://dx.doi.org/10.1016/j.scitotenv.2015.03.009 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25765378 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-FOR SSG-OPC-GGO GBV_ILN_21 GBV_ILN_70 GBV_ILN_4012 AR 518-519 2015 258-265 |
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Cermola, Flavio @@aut@@ Passananti, Monica @@oth@@ Criscuolo, Emma @@oth@@ Brigante, Marcello @@oth@@ DellaGreca, Marina @@oth@@ Lavorgna, Margherita @@oth@@ Isidori, Marina @@oth@@ Iesce, Maria Rosaria @@oth@@ |
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photochemical fate and eco-genotoxicity assessment of the drug etodolac |
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Photochemical fate and eco-genotoxicity assessment of the drug etodolac |
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The photochemical behavior of etodolac was investigated under various irradiation conditions. Kinetic data were obtained after irradiation of 10(-4) M aqueous solutions by UVB, UVA and direct exposure to sunlight. The Xenon lamp irradiation was used in order to determine the photodegradation quantum yield under sun-simulated condition (ϕsun). The value was determined to be=0.10±0.01. In order to obtain photoproducts and for mechanistic purposes, experiments were carried out on more concentrated solutions by exposure to sunlight and to UVA and UVB lamps. The drug underwent photooxidative processes following an initial oxygen addition to the double bond of the five membered ring and was mainly converted into a spiro compound and a macrolactam. Ecotoxicity tests were performed on etodolac, its photostable spiro derivative and its sunlight irradiation mixture on two different aquatic trophic levels, plants (algae) and invertebrates (rotifers and crustaceans). Mutagenesis and genotoxicity were detected on bacterial strains. The results showed that only etodolac had long term effects on rotifers although at concentrations far from environmental detection values. A mutagenic and genotoxic potential was found for its derivative. |
| abstractGer |
The photochemical behavior of etodolac was investigated under various irradiation conditions. Kinetic data were obtained after irradiation of 10(-4) M aqueous solutions by UVB, UVA and direct exposure to sunlight. The Xenon lamp irradiation was used in order to determine the photodegradation quantum yield under sun-simulated condition (ϕsun). The value was determined to be=0.10±0.01. In order to obtain photoproducts and for mechanistic purposes, experiments were carried out on more concentrated solutions by exposure to sunlight and to UVA and UVB lamps. The drug underwent photooxidative processes following an initial oxygen addition to the double bond of the five membered ring and was mainly converted into a spiro compound and a macrolactam. Ecotoxicity tests were performed on etodolac, its photostable spiro derivative and its sunlight irradiation mixture on two different aquatic trophic levels, plants (algae) and invertebrates (rotifers and crustaceans). Mutagenesis and genotoxicity were detected on bacterial strains. The results showed that only etodolac had long term effects on rotifers although at concentrations far from environmental detection values. A mutagenic and genotoxic potential was found for its derivative. |
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The photochemical behavior of etodolac was investigated under various irradiation conditions. Kinetic data were obtained after irradiation of 10(-4) M aqueous solutions by UVB, UVA and direct exposure to sunlight. The Xenon lamp irradiation was used in order to determine the photodegradation quantum yield under sun-simulated condition (ϕsun). The value was determined to be=0.10±0.01. In order to obtain photoproducts and for mechanistic purposes, experiments were carried out on more concentrated solutions by exposure to sunlight and to UVA and UVB lamps. The drug underwent photooxidative processes following an initial oxygen addition to the double bond of the five membered ring and was mainly converted into a spiro compound and a macrolactam. Ecotoxicity tests were performed on etodolac, its photostable spiro derivative and its sunlight irradiation mixture on two different aquatic trophic levels, plants (algae) and invertebrates (rotifers and crustaceans). Mutagenesis and genotoxicity were detected on bacterial strains. The results showed that only etodolac had long term effects on rotifers although at concentrations far from environmental detection values. A mutagenic and genotoxic potential was found for its derivative. |
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Photochemical fate and eco-genotoxicity assessment of the drug etodolac |
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Passananti, Monica Criscuolo, Emma Brigante, Marcello DellaGreca, Marina Lavorgna, Margherita Isidori, Marina Iesce, Maria Rosaria |
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