Assessment of biomarkers for contaminants of emerging concern on aquatic organisms downstream of a municipal wastewater discharge
Contaminants of emerging concern (CECs), including pharmaceuticals, personal care products and estrogens, are detected in wastewater treatment plant (WWTP) discharges. However, analytical monitoring of wastewater and surface water does not indicate whether CECs are affecting the organisms downstream...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Moon, Thomas W [verfasserIn] |
|---|
| Format: |
Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Rechteinformationen: |
Nutzungsrecht: Copyright © 2015 Elsevier B.V. All rights reserved. |
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| Schlagwörter: |
Aquatic Organisms - metabolism |
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| Übergeordnetes Werk: |
Enthalten in: The science of the total environment - Amsterdam : Elsevier, 1972, 530-531(2015), Seite 140-153 |
|---|---|
| Übergeordnetes Werk: |
volume:530-531 ; year:2015 ; pages:140-153 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.scitotenv.2015.05.080 |
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| Katalog-ID: |
OLC1969691441 |
|---|
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| 520 | |a Contaminants of emerging concern (CECs), including pharmaceuticals, personal care products and estrogens, are detected in wastewater treatment plant (WWTP) discharges. However, analytical monitoring of wastewater and surface water does not indicate whether CECs are affecting the organisms downstream. In this study, fathead minnows (Pimephales promelas) and freshwater mussels Pyganodon grandis Say, 1829 (synonym: Anodonta grandis Say, 1829) were caged for 4 weeks in the North Saskatchewan River, upstream and downstream of the discharge from the WWTP that serves the Edmonton, AB, Canada. Passive samplers deployed indicated that concentrations of pharmaceuticals, personal care products, an estrogen (estrone) and an androgen (androstenedione) were elevated at sites downstream of the WWTP discharge. Several biomarkers of exposure were significantly altered in the tissues of caged fathead minnows and freshwater mussels relative to the upstream reference sites. Biomarkers altered in fish included induction of CYP3A metabolism, an increase in vitellogenin (Vtg) gene expression in male minnows, elevated ratios of oxidized to total glutathione (i.e. GSSG/TGSH), and an increase in the activity of antioxidant enzymes (i.e. glutathione reductase, glutathione-S-transferase). In mussels, there were no significant changes in biomarkers of oxidative stress and the levels of Vtg-like proteins were reduced, not elevated, indicating a generalized stress response. Immune function was altered in mussels, as indicated by elevated lysosomal activity per hemocyte in P. grandis caged closest to the wastewater discharge. This immune response may be due to exposure to bacterial pathogens in the wastewater. Multivariate analysis indicated a response to the CECs Carbamazepine (CBZ) and Trimethoprim (TPM). Overall, these data indicate that there is a 1 km zone of impact for aquatic organisms downstream of WWTP discharge. However, multiple stressors in municipal wastewater make measurement and interpretation of impact of CECs difficult since water temperature, conductivity and bacteria are also inducing biomarker responses in both fish and mussels. | ||
| 540 | |a Nutzungsrecht: Copyright © 2015 Elsevier B.V. All rights reserved. | ||
| 650 | 4 | |a Aquatic Organisms - metabolism | |
| 650 | 4 | |a Vitellogenins - metabolism | |
| 650 | 4 | |a Unionidae - metabolism | |
| 650 | 4 | |a Bivalvia - metabolism | |
| 650 | 4 | |a Hemocytes - metabolism | |
| 650 | 4 | |a Biomarkers - metabolism | |
| 650 | 4 | |a Cyprinidae - metabolism | |
| 650 | 4 | |a Water Pollutants, Chemical - metabolism | |
| 650 | 4 | |a Waste Water - chemistry | |
| 700 | 1 | |a Sultana, Tamanna |4 oth | |
| 700 | 1 | |a Gillis, Patricia L |4 oth | |
| 700 | 1 | |a Giacomin, Marina |4 oth | |
| 700 | 1 | |a Servos, Mark R |4 oth | |
| 700 | 1 | |a Wilson, Joanna |4 oth | |
| 700 | 1 | |a de Souza Machado, Anderson A |4 oth | |
| 700 | 1 | |a Massarsky, Andrey |4 oth | |
| 700 | 1 | |a Van Der Kraak, Glen J |4 oth | |
| 700 | 1 | |a Gagné, Francois |4 oth | |
| 700 | 1 | |a Metcalfe, Chris D |4 oth | |
| 700 | 1 | |a Goss, Greg G |4 oth | |
| 700 | 1 | |a Jasinska, Edyta J |4 oth | |
| 700 | 1 | |a Matsumoto, Jacqueline |4 oth | |
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10.1016/j.scitotenv.2015.05.080 doi PQ20160211 (DE-627)OLC1969691441 (DE-599)GBVOLC1969691441 (PRQ)c1316-cc9c8ff69915a081ca3e93d044dbd63daf678bb2c83b6006cfb3f8ea0f90f930 (KEY)0073664320150000530000000140assessmentofbiomarkersforcontaminantsofemergingcon DE-627 ger DE-627 rakwb eng 570 333.7 610 DNB Moon, Thomas W verfasserin aut Assessment of biomarkers for contaminants of emerging concern on aquatic organisms downstream of a municipal wastewater discharge 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Contaminants of emerging concern (CECs), including pharmaceuticals, personal care products and estrogens, are detected in wastewater treatment plant (WWTP) discharges. However, analytical monitoring of wastewater and surface water does not indicate whether CECs are affecting the organisms downstream. In this study, fathead minnows (Pimephales promelas) and freshwater mussels Pyganodon grandis Say, 1829 (synonym: Anodonta grandis Say, 1829) were caged for 4 weeks in the North Saskatchewan River, upstream and downstream of the discharge from the WWTP that serves the Edmonton, AB, Canada. Passive samplers deployed indicated that concentrations of pharmaceuticals, personal care products, an estrogen (estrone) and an androgen (androstenedione) were elevated at sites downstream of the WWTP discharge. Several biomarkers of exposure were significantly altered in the tissues of caged fathead minnows and freshwater mussels relative to the upstream reference sites. Biomarkers altered in fish included induction of CYP3A metabolism, an increase in vitellogenin (Vtg) gene expression in male minnows, elevated ratios of oxidized to total glutathione (i.e. GSSG/TGSH), and an increase in the activity of antioxidant enzymes (i.e. glutathione reductase, glutathione-S-transferase). In mussels, there were no significant changes in biomarkers of oxidative stress and the levels of Vtg-like proteins were reduced, not elevated, indicating a generalized stress response. Immune function was altered in mussels, as indicated by elevated lysosomal activity per hemocyte in P. grandis caged closest to the wastewater discharge. This immune response may be due to exposure to bacterial pathogens in the wastewater. Multivariate analysis indicated a response to the CECs Carbamazepine (CBZ) and Trimethoprim (TPM). Overall, these data indicate that there is a 1 km zone of impact for aquatic organisms downstream of WWTP discharge. However, multiple stressors in municipal wastewater make measurement and interpretation of impact of CECs difficult since water temperature, conductivity and bacteria are also inducing biomarker responses in both fish and mussels. Nutzungsrecht: Copyright © 2015 Elsevier B.V. All rights reserved. Aquatic Organisms - metabolism Vitellogenins - metabolism Unionidae - metabolism Bivalvia - metabolism Hemocytes - metabolism Biomarkers - metabolism Cyprinidae - metabolism Water Pollutants, Chemical - metabolism Waste Water - chemistry Sultana, Tamanna oth Gillis, Patricia L oth Giacomin, Marina oth Servos, Mark R oth Wilson, Joanna oth de Souza Machado, Anderson A oth Massarsky, Andrey oth Van Der Kraak, Glen J oth Gagné, Francois oth Metcalfe, Chris D oth Goss, Greg G oth Jasinska, Edyta J oth Matsumoto, Jacqueline oth Enthalten in The science of the total environment Amsterdam : Elsevier, 1972 530-531(2015), Seite 140-153 (DE-627)129297917 (DE-600)121506-1 (DE-576)014490919 0048-9697 nnns volume:530-531 year:2015 pages:140-153 http://dx.doi.org/10.1016/j.scitotenv.2015.05.080 Volltext http://www.ncbi.nlm.nih.gov/pubmed/26026416 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-FOR SSG-OPC-GGO GBV_ILN_21 GBV_ILN_70 GBV_ILN_4012 AR 530-531 2015 140-153 |
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10.1016/j.scitotenv.2015.05.080 doi PQ20160211 (DE-627)OLC1969691441 (DE-599)GBVOLC1969691441 (PRQ)c1316-cc9c8ff69915a081ca3e93d044dbd63daf678bb2c83b6006cfb3f8ea0f90f930 (KEY)0073664320150000530000000140assessmentofbiomarkersforcontaminantsofemergingcon DE-627 ger DE-627 rakwb eng 570 333.7 610 DNB Moon, Thomas W verfasserin aut Assessment of biomarkers for contaminants of emerging concern on aquatic organisms downstream of a municipal wastewater discharge 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Contaminants of emerging concern (CECs), including pharmaceuticals, personal care products and estrogens, are detected in wastewater treatment plant (WWTP) discharges. However, analytical monitoring of wastewater and surface water does not indicate whether CECs are affecting the organisms downstream. In this study, fathead minnows (Pimephales promelas) and freshwater mussels Pyganodon grandis Say, 1829 (synonym: Anodonta grandis Say, 1829) were caged for 4 weeks in the North Saskatchewan River, upstream and downstream of the discharge from the WWTP that serves the Edmonton, AB, Canada. Passive samplers deployed indicated that concentrations of pharmaceuticals, personal care products, an estrogen (estrone) and an androgen (androstenedione) were elevated at sites downstream of the WWTP discharge. Several biomarkers of exposure were significantly altered in the tissues of caged fathead minnows and freshwater mussels relative to the upstream reference sites. Biomarkers altered in fish included induction of CYP3A metabolism, an increase in vitellogenin (Vtg) gene expression in male minnows, elevated ratios of oxidized to total glutathione (i.e. GSSG/TGSH), and an increase in the activity of antioxidant enzymes (i.e. glutathione reductase, glutathione-S-transferase). In mussels, there were no significant changes in biomarkers of oxidative stress and the levels of Vtg-like proteins were reduced, not elevated, indicating a generalized stress response. Immune function was altered in mussels, as indicated by elevated lysosomal activity per hemocyte in P. grandis caged closest to the wastewater discharge. This immune response may be due to exposure to bacterial pathogens in the wastewater. Multivariate analysis indicated a response to the CECs Carbamazepine (CBZ) and Trimethoprim (TPM). Overall, these data indicate that there is a 1 km zone of impact for aquatic organisms downstream of WWTP discharge. However, multiple stressors in municipal wastewater make measurement and interpretation of impact of CECs difficult since water temperature, conductivity and bacteria are also inducing biomarker responses in both fish and mussels. Nutzungsrecht: Copyright © 2015 Elsevier B.V. All rights reserved. Aquatic Organisms - metabolism Vitellogenins - metabolism Unionidae - metabolism Bivalvia - metabolism Hemocytes - metabolism Biomarkers - metabolism Cyprinidae - metabolism Water Pollutants, Chemical - metabolism Waste Water - chemistry Sultana, Tamanna oth Gillis, Patricia L oth Giacomin, Marina oth Servos, Mark R oth Wilson, Joanna oth de Souza Machado, Anderson A oth Massarsky, Andrey oth Van Der Kraak, Glen J oth Gagné, Francois oth Metcalfe, Chris D oth Goss, Greg G oth Jasinska, Edyta J oth Matsumoto, Jacqueline oth Enthalten in The science of the total environment Amsterdam : Elsevier, 1972 530-531(2015), Seite 140-153 (DE-627)129297917 (DE-600)121506-1 (DE-576)014490919 0048-9697 nnns volume:530-531 year:2015 pages:140-153 http://dx.doi.org/10.1016/j.scitotenv.2015.05.080 Volltext http://www.ncbi.nlm.nih.gov/pubmed/26026416 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-FOR SSG-OPC-GGO GBV_ILN_21 GBV_ILN_70 GBV_ILN_4012 AR 530-531 2015 140-153 |
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10.1016/j.scitotenv.2015.05.080 doi PQ20160211 (DE-627)OLC1969691441 (DE-599)GBVOLC1969691441 (PRQ)c1316-cc9c8ff69915a081ca3e93d044dbd63daf678bb2c83b6006cfb3f8ea0f90f930 (KEY)0073664320150000530000000140assessmentofbiomarkersforcontaminantsofemergingcon DE-627 ger DE-627 rakwb eng 570 333.7 610 DNB Moon, Thomas W verfasserin aut Assessment of biomarkers for contaminants of emerging concern on aquatic organisms downstream of a municipal wastewater discharge 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Contaminants of emerging concern (CECs), including pharmaceuticals, personal care products and estrogens, are detected in wastewater treatment plant (WWTP) discharges. However, analytical monitoring of wastewater and surface water does not indicate whether CECs are affecting the organisms downstream. In this study, fathead minnows (Pimephales promelas) and freshwater mussels Pyganodon grandis Say, 1829 (synonym: Anodonta grandis Say, 1829) were caged for 4 weeks in the North Saskatchewan River, upstream and downstream of the discharge from the WWTP that serves the Edmonton, AB, Canada. Passive samplers deployed indicated that concentrations of pharmaceuticals, personal care products, an estrogen (estrone) and an androgen (androstenedione) were elevated at sites downstream of the WWTP discharge. Several biomarkers of exposure were significantly altered in the tissues of caged fathead minnows and freshwater mussels relative to the upstream reference sites. Biomarkers altered in fish included induction of CYP3A metabolism, an increase in vitellogenin (Vtg) gene expression in male minnows, elevated ratios of oxidized to total glutathione (i.e. GSSG/TGSH), and an increase in the activity of antioxidant enzymes (i.e. glutathione reductase, glutathione-S-transferase). In mussels, there were no significant changes in biomarkers of oxidative stress and the levels of Vtg-like proteins were reduced, not elevated, indicating a generalized stress response. Immune function was altered in mussels, as indicated by elevated lysosomal activity per hemocyte in P. grandis caged closest to the wastewater discharge. This immune response may be due to exposure to bacterial pathogens in the wastewater. Multivariate analysis indicated a response to the CECs Carbamazepine (CBZ) and Trimethoprim (TPM). Overall, these data indicate that there is a 1 km zone of impact for aquatic organisms downstream of WWTP discharge. However, multiple stressors in municipal wastewater make measurement and interpretation of impact of CECs difficult since water temperature, conductivity and bacteria are also inducing biomarker responses in both fish and mussels. Nutzungsrecht: Copyright © 2015 Elsevier B.V. All rights reserved. Aquatic Organisms - metabolism Vitellogenins - metabolism Unionidae - metabolism Bivalvia - metabolism Hemocytes - metabolism Biomarkers - metabolism Cyprinidae - metabolism Water Pollutants, Chemical - metabolism Waste Water - chemistry Sultana, Tamanna oth Gillis, Patricia L oth Giacomin, Marina oth Servos, Mark R oth Wilson, Joanna oth de Souza Machado, Anderson A oth Massarsky, Andrey oth Van Der Kraak, Glen J oth Gagné, Francois oth Metcalfe, Chris D oth Goss, Greg G oth Jasinska, Edyta J oth Matsumoto, Jacqueline oth Enthalten in The science of the total environment Amsterdam : Elsevier, 1972 530-531(2015), Seite 140-153 (DE-627)129297917 (DE-600)121506-1 (DE-576)014490919 0048-9697 nnns volume:530-531 year:2015 pages:140-153 http://dx.doi.org/10.1016/j.scitotenv.2015.05.080 Volltext http://www.ncbi.nlm.nih.gov/pubmed/26026416 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-FOR SSG-OPC-GGO GBV_ILN_21 GBV_ILN_70 GBV_ILN_4012 AR 530-531 2015 140-153 |
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10.1016/j.scitotenv.2015.05.080 doi PQ20160211 (DE-627)OLC1969691441 (DE-599)GBVOLC1969691441 (PRQ)c1316-cc9c8ff69915a081ca3e93d044dbd63daf678bb2c83b6006cfb3f8ea0f90f930 (KEY)0073664320150000530000000140assessmentofbiomarkersforcontaminantsofemergingcon DE-627 ger DE-627 rakwb eng 570 333.7 610 DNB Moon, Thomas W verfasserin aut Assessment of biomarkers for contaminants of emerging concern on aquatic organisms downstream of a municipal wastewater discharge 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Contaminants of emerging concern (CECs), including pharmaceuticals, personal care products and estrogens, are detected in wastewater treatment plant (WWTP) discharges. However, analytical monitoring of wastewater and surface water does not indicate whether CECs are affecting the organisms downstream. In this study, fathead minnows (Pimephales promelas) and freshwater mussels Pyganodon grandis Say, 1829 (synonym: Anodonta grandis Say, 1829) were caged for 4 weeks in the North Saskatchewan River, upstream and downstream of the discharge from the WWTP that serves the Edmonton, AB, Canada. Passive samplers deployed indicated that concentrations of pharmaceuticals, personal care products, an estrogen (estrone) and an androgen (androstenedione) were elevated at sites downstream of the WWTP discharge. Several biomarkers of exposure were significantly altered in the tissues of caged fathead minnows and freshwater mussels relative to the upstream reference sites. Biomarkers altered in fish included induction of CYP3A metabolism, an increase in vitellogenin (Vtg) gene expression in male minnows, elevated ratios of oxidized to total glutathione (i.e. GSSG/TGSH), and an increase in the activity of antioxidant enzymes (i.e. glutathione reductase, glutathione-S-transferase). In mussels, there were no significant changes in biomarkers of oxidative stress and the levels of Vtg-like proteins were reduced, not elevated, indicating a generalized stress response. Immune function was altered in mussels, as indicated by elevated lysosomal activity per hemocyte in P. grandis caged closest to the wastewater discharge. This immune response may be due to exposure to bacterial pathogens in the wastewater. Multivariate analysis indicated a response to the CECs Carbamazepine (CBZ) and Trimethoprim (TPM). Overall, these data indicate that there is a 1 km zone of impact for aquatic organisms downstream of WWTP discharge. However, multiple stressors in municipal wastewater make measurement and interpretation of impact of CECs difficult since water temperature, conductivity and bacteria are also inducing biomarker responses in both fish and mussels. Nutzungsrecht: Copyright © 2015 Elsevier B.V. All rights reserved. Aquatic Organisms - metabolism Vitellogenins - metabolism Unionidae - metabolism Bivalvia - metabolism Hemocytes - metabolism Biomarkers - metabolism Cyprinidae - metabolism Water Pollutants, Chemical - metabolism Waste Water - chemistry Sultana, Tamanna oth Gillis, Patricia L oth Giacomin, Marina oth Servos, Mark R oth Wilson, Joanna oth de Souza Machado, Anderson A oth Massarsky, Andrey oth Van Der Kraak, Glen J oth Gagné, Francois oth Metcalfe, Chris D oth Goss, Greg G oth Jasinska, Edyta J oth Matsumoto, Jacqueline oth Enthalten in The science of the total environment Amsterdam : Elsevier, 1972 530-531(2015), Seite 140-153 (DE-627)129297917 (DE-600)121506-1 (DE-576)014490919 0048-9697 nnns volume:530-531 year:2015 pages:140-153 http://dx.doi.org/10.1016/j.scitotenv.2015.05.080 Volltext http://www.ncbi.nlm.nih.gov/pubmed/26026416 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-FOR SSG-OPC-GGO GBV_ILN_21 GBV_ILN_70 GBV_ILN_4012 AR 530-531 2015 140-153 |
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10.1016/j.scitotenv.2015.05.080 doi PQ20160211 (DE-627)OLC1969691441 (DE-599)GBVOLC1969691441 (PRQ)c1316-cc9c8ff69915a081ca3e93d044dbd63daf678bb2c83b6006cfb3f8ea0f90f930 (KEY)0073664320150000530000000140assessmentofbiomarkersforcontaminantsofemergingcon DE-627 ger DE-627 rakwb eng 570 333.7 610 DNB Moon, Thomas W verfasserin aut Assessment of biomarkers for contaminants of emerging concern on aquatic organisms downstream of a municipal wastewater discharge 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Contaminants of emerging concern (CECs), including pharmaceuticals, personal care products and estrogens, are detected in wastewater treatment plant (WWTP) discharges. However, analytical monitoring of wastewater and surface water does not indicate whether CECs are affecting the organisms downstream. In this study, fathead minnows (Pimephales promelas) and freshwater mussels Pyganodon grandis Say, 1829 (synonym: Anodonta grandis Say, 1829) were caged for 4 weeks in the North Saskatchewan River, upstream and downstream of the discharge from the WWTP that serves the Edmonton, AB, Canada. Passive samplers deployed indicated that concentrations of pharmaceuticals, personal care products, an estrogen (estrone) and an androgen (androstenedione) were elevated at sites downstream of the WWTP discharge. Several biomarkers of exposure were significantly altered in the tissues of caged fathead minnows and freshwater mussels relative to the upstream reference sites. Biomarkers altered in fish included induction of CYP3A metabolism, an increase in vitellogenin (Vtg) gene expression in male minnows, elevated ratios of oxidized to total glutathione (i.e. GSSG/TGSH), and an increase in the activity of antioxidant enzymes (i.e. glutathione reductase, glutathione-S-transferase). In mussels, there were no significant changes in biomarkers of oxidative stress and the levels of Vtg-like proteins were reduced, not elevated, indicating a generalized stress response. Immune function was altered in mussels, as indicated by elevated lysosomal activity per hemocyte in P. grandis caged closest to the wastewater discharge. This immune response may be due to exposure to bacterial pathogens in the wastewater. Multivariate analysis indicated a response to the CECs Carbamazepine (CBZ) and Trimethoprim (TPM). Overall, these data indicate that there is a 1 km zone of impact for aquatic organisms downstream of WWTP discharge. However, multiple stressors in municipal wastewater make measurement and interpretation of impact of CECs difficult since water temperature, conductivity and bacteria are also inducing biomarker responses in both fish and mussels. Nutzungsrecht: Copyright © 2015 Elsevier B.V. All rights reserved. Aquatic Organisms - metabolism Vitellogenins - metabolism Unionidae - metabolism Bivalvia - metabolism Hemocytes - metabolism Biomarkers - metabolism Cyprinidae - metabolism Water Pollutants, Chemical - metabolism Waste Water - chemistry Sultana, Tamanna oth Gillis, Patricia L oth Giacomin, Marina oth Servos, Mark R oth Wilson, Joanna oth de Souza Machado, Anderson A oth Massarsky, Andrey oth Van Der Kraak, Glen J oth Gagné, Francois oth Metcalfe, Chris D oth Goss, Greg G oth Jasinska, Edyta J oth Matsumoto, Jacqueline oth Enthalten in The science of the total environment Amsterdam : Elsevier, 1972 530-531(2015), Seite 140-153 (DE-627)129297917 (DE-600)121506-1 (DE-576)014490919 0048-9697 nnns volume:530-531 year:2015 pages:140-153 http://dx.doi.org/10.1016/j.scitotenv.2015.05.080 Volltext http://www.ncbi.nlm.nih.gov/pubmed/26026416 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-FOR SSG-OPC-GGO GBV_ILN_21 GBV_ILN_70 GBV_ILN_4012 AR 530-531 2015 140-153 |
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assessment of biomarkers for contaminants of emerging concern on aquatic organisms downstream of a municipal wastewater discharge |
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Assessment of biomarkers for contaminants of emerging concern on aquatic organisms downstream of a municipal wastewater discharge |
| abstract |
Contaminants of emerging concern (CECs), including pharmaceuticals, personal care products and estrogens, are detected in wastewater treatment plant (WWTP) discharges. However, analytical monitoring of wastewater and surface water does not indicate whether CECs are affecting the organisms downstream. In this study, fathead minnows (Pimephales promelas) and freshwater mussels Pyganodon grandis Say, 1829 (synonym: Anodonta grandis Say, 1829) were caged for 4 weeks in the North Saskatchewan River, upstream and downstream of the discharge from the WWTP that serves the Edmonton, AB, Canada. Passive samplers deployed indicated that concentrations of pharmaceuticals, personal care products, an estrogen (estrone) and an androgen (androstenedione) were elevated at sites downstream of the WWTP discharge. Several biomarkers of exposure were significantly altered in the tissues of caged fathead minnows and freshwater mussels relative to the upstream reference sites. Biomarkers altered in fish included induction of CYP3A metabolism, an increase in vitellogenin (Vtg) gene expression in male minnows, elevated ratios of oxidized to total glutathione (i.e. GSSG/TGSH), and an increase in the activity of antioxidant enzymes (i.e. glutathione reductase, glutathione-S-transferase). In mussels, there were no significant changes in biomarkers of oxidative stress and the levels of Vtg-like proteins were reduced, not elevated, indicating a generalized stress response. Immune function was altered in mussels, as indicated by elevated lysosomal activity per hemocyte in P. grandis caged closest to the wastewater discharge. This immune response may be due to exposure to bacterial pathogens in the wastewater. Multivariate analysis indicated a response to the CECs Carbamazepine (CBZ) and Trimethoprim (TPM). Overall, these data indicate that there is a 1 km zone of impact for aquatic organisms downstream of WWTP discharge. However, multiple stressors in municipal wastewater make measurement and interpretation of impact of CECs difficult since water temperature, conductivity and bacteria are also inducing biomarker responses in both fish and mussels. |
| abstractGer |
Contaminants of emerging concern (CECs), including pharmaceuticals, personal care products and estrogens, are detected in wastewater treatment plant (WWTP) discharges. However, analytical monitoring of wastewater and surface water does not indicate whether CECs are affecting the organisms downstream. In this study, fathead minnows (Pimephales promelas) and freshwater mussels Pyganodon grandis Say, 1829 (synonym: Anodonta grandis Say, 1829) were caged for 4 weeks in the North Saskatchewan River, upstream and downstream of the discharge from the WWTP that serves the Edmonton, AB, Canada. Passive samplers deployed indicated that concentrations of pharmaceuticals, personal care products, an estrogen (estrone) and an androgen (androstenedione) were elevated at sites downstream of the WWTP discharge. Several biomarkers of exposure were significantly altered in the tissues of caged fathead minnows and freshwater mussels relative to the upstream reference sites. Biomarkers altered in fish included induction of CYP3A metabolism, an increase in vitellogenin (Vtg) gene expression in male minnows, elevated ratios of oxidized to total glutathione (i.e. GSSG/TGSH), and an increase in the activity of antioxidant enzymes (i.e. glutathione reductase, glutathione-S-transferase). In mussels, there were no significant changes in biomarkers of oxidative stress and the levels of Vtg-like proteins were reduced, not elevated, indicating a generalized stress response. Immune function was altered in mussels, as indicated by elevated lysosomal activity per hemocyte in P. grandis caged closest to the wastewater discharge. This immune response may be due to exposure to bacterial pathogens in the wastewater. Multivariate analysis indicated a response to the CECs Carbamazepine (CBZ) and Trimethoprim (TPM). Overall, these data indicate that there is a 1 km zone of impact for aquatic organisms downstream of WWTP discharge. However, multiple stressors in municipal wastewater make measurement and interpretation of impact of CECs difficult since water temperature, conductivity and bacteria are also inducing biomarker responses in both fish and mussels. |
| abstract_unstemmed |
Contaminants of emerging concern (CECs), including pharmaceuticals, personal care products and estrogens, are detected in wastewater treatment plant (WWTP) discharges. However, analytical monitoring of wastewater and surface water does not indicate whether CECs are affecting the organisms downstream. In this study, fathead minnows (Pimephales promelas) and freshwater mussels Pyganodon grandis Say, 1829 (synonym: Anodonta grandis Say, 1829) were caged for 4 weeks in the North Saskatchewan River, upstream and downstream of the discharge from the WWTP that serves the Edmonton, AB, Canada. Passive samplers deployed indicated that concentrations of pharmaceuticals, personal care products, an estrogen (estrone) and an androgen (androstenedione) were elevated at sites downstream of the WWTP discharge. Several biomarkers of exposure were significantly altered in the tissues of caged fathead minnows and freshwater mussels relative to the upstream reference sites. Biomarkers altered in fish included induction of CYP3A metabolism, an increase in vitellogenin (Vtg) gene expression in male minnows, elevated ratios of oxidized to total glutathione (i.e. GSSG/TGSH), and an increase in the activity of antioxidant enzymes (i.e. glutathione reductase, glutathione-S-transferase). In mussels, there were no significant changes in biomarkers of oxidative stress and the levels of Vtg-like proteins were reduced, not elevated, indicating a generalized stress response. Immune function was altered in mussels, as indicated by elevated lysosomal activity per hemocyte in P. grandis caged closest to the wastewater discharge. This immune response may be due to exposure to bacterial pathogens in the wastewater. Multivariate analysis indicated a response to the CECs Carbamazepine (CBZ) and Trimethoprim (TPM). Overall, these data indicate that there is a 1 km zone of impact for aquatic organisms downstream of WWTP discharge. However, multiple stressors in municipal wastewater make measurement and interpretation of impact of CECs difficult since water temperature, conductivity and bacteria are also inducing biomarker responses in both fish and mussels. |
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Assessment of biomarkers for contaminants of emerging concern on aquatic organisms downstream of a municipal wastewater discharge |
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Biomarkers altered in fish included induction of CYP3A metabolism, an increase in vitellogenin (Vtg) gene expression in male minnows, elevated ratios of oxidized to total glutathione (i.e. GSSG/TGSH), and an increase in the activity of antioxidant enzymes (i.e. glutathione reductase, glutathione-S-transferase). In mussels, there were no significant changes in biomarkers of oxidative stress and the levels of Vtg-like proteins were reduced, not elevated, indicating a generalized stress response. Immune function was altered in mussels, as indicated by elevated lysosomal activity per hemocyte in P. grandis caged closest to the wastewater discharge. This immune response may be due to exposure to bacterial pathogens in the wastewater. Multivariate analysis indicated a response to the CECs Carbamazepine (CBZ) and Trimethoprim (TPM). Overall, these data indicate that there is a 1 km zone of impact for aquatic organisms downstream of WWTP discharge. However, multiple stressors in municipal wastewater make measurement and interpretation of impact of CECs difficult since water temperature, conductivity and bacteria are also inducing biomarker responses in both fish and mussels.</subfield></datafield><datafield tag="540" ind1=" " ind2=" "><subfield code="a">Nutzungsrecht: Copyright © 2015 Elsevier B.V. All rights reserved.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Aquatic Organisms - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Vitellogenins - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Unionidae - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Bivalvia - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Hemocytes - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Biomarkers - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cyprinidae - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Water Pollutants, Chemical - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Waste Water - chemistry</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sultana, Tamanna</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gillis, Patricia L</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Giacomin, Marina</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Servos, Mark R</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wilson, Joanna</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">de Souza Machado, Anderson A</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Massarsky, Andrey</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Van Der Kraak, Glen J</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gagné, Francois</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Metcalfe, Chris D</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Goss, Greg G</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Jasinska, Edyta J</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Matsumoto, Jacqueline</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">The science of the total environment</subfield><subfield code="d">Amsterdam : Elsevier, 1972</subfield><subfield code="g">530-531(2015), Seite 140-153</subfield><subfield code="w">(DE-627)129297917</subfield><subfield code="w">(DE-600)121506-1</subfield><subfield code="w">(DE-576)014490919</subfield><subfield code="x">0048-9697</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:530-531</subfield><subfield code="g">year:2015</subfield><subfield code="g">pages:140-153</subfield></datafield><datafield tag="856" ind1="4" ind2="1"><subfield code="u">http://dx.doi.org/10.1016/j.scitotenv.2015.05.080</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">http://www.ncbi.nlm.nih.gov/pubmed/26026416</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_OLC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-UMW</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-FOR</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OPC-GGO</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_21</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">530-531</subfield><subfield code="j">2015</subfield><subfield code="h">140-153</subfield></datafield></record></collection>
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