Purification, characterization and neuroprotective effects of a polysaccharide from Gynostemma pentaphyllum

In the present study, we investigated the neuroprotective effects of GPP1, a purified polysaccharide from Gynostemma pentaphyllum, on Aβ (25-35)-induced neuronal toxicity and explore its potential mechanisms in PC12 cells. The results showed pretreatment with GPP1 prior to Aβ (25-35) exposure signif...
Ausführliche Beschreibung

Gespeichert in:
Autor*in:

Rao, Chunguang [verfasserIn]

Lei, Jinli

Xue, Shengxiang

Jia, Dong

Format:

Artikel

Sprache:

Englisch

Erschienen:

2015

Rechteinformationen:

Nutzungsrecht: Copyright © 2015 Elsevier Ltd. All rights reserved.

Schlagwörter:

Amyloid beta-Peptides - toxicity

Neuroprotective Agents - chemistry

Neuroprotective Agents - isolation & purification

Mitochondria - drug effects

Gynostemma - chemistry

Cytochromes c - secretion

Neuroprotective Agents - pharmacology

Calcium - metabolism

Gene Expression Regulation - drug effects

Peptide Fragments - toxicity

Oxidative Stress - drug effects

Polysaccharides - pharmacology

Apoptosis - drug effects

Signal Transduction - drug effects

Polysaccharides - chemistry

Polysaccharides - isolation & purification

Übergeordnetes Werk:

Enthalten in: Carbohydrate polymers - Barking, Essex : Applied Science Publ., 1981, 122(2015), Seite 93-100

Übergeordnetes Werk:

volume:122 ; year:2015 ; pages:93-100

Links:

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DOI / URN:

10.1016/j.carbpol.2014.12.032

Katalog-ID:

OLC1969818115

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