Purification, characterization and neuroprotective effects of a polysaccharide from Gynostemma pentaphyllum
In the present study, we investigated the neuroprotective effects of GPP1, a purified polysaccharide from Gynostemma pentaphyllum, on Aβ (25-35)-induced neuronal toxicity and explore its potential mechanisms in PC12 cells. The results showed pretreatment with GPP1 prior to Aβ (25-35) exposure signif...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Rao, Chunguang [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Rechteinformationen: |
Nutzungsrecht: Copyright © 2015 Elsevier Ltd. All rights reserved. |
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| Übergeordnetes Werk: |
Enthalten in: Carbohydrate polymers - Barking, Essex : Applied Science Publ., 1981, 122(2015), Seite 93-100 |
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| Übergeordnetes Werk: |
volume:122 ; year:2015 ; pages:93-100 |
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| DOI / URN: |
10.1016/j.carbpol.2014.12.032 |
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| 520 | |a In the present study, we investigated the neuroprotective effects of GPP1, a purified polysaccharide from Gynostemma pentaphyllum, on Aβ (25-35)-induced neuronal toxicity and explore its potential mechanisms in PC12 cells. The results showed pretreatment with GPP1 prior to Aβ (25-35) exposure significantly protected PC12 cells from Aβ (25-35)-induced cell death, lactate dehydrogenase (LDH) release, DNA damage, intracellular free calcium concentration ([Ca(2+)]i) influx, mitochondrial dysfunction and mitochondrial cytochrome c (Cyt-C) release. In addition, pretreatment with GPP1 also protected PC12 cells against Aβ (25-35)-induced the accumulation of reactive oxygen species (ROS) and lipid peroxidation product MDA, the reduction in glutathione (GSH) level and superoxide dismutase (SOD) activity, the increased Bax/Bcl-2 protein expression ratio and caspase-3 activation. Our findings suggest that GPP1 exerts a neuroprotective effect against Aβ (25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative stress and suppressing the mitochondrial apoptotic pathway. | ||
| 540 | |a Nutzungsrecht: Copyright © 2015 Elsevier Ltd. All rights reserved. | ||
| 650 | 4 | |a Amyloid beta-Peptides - toxicity | |
| 650 | 4 | |a Neuroprotective Agents - chemistry | |
| 650 | 4 | |a Neuroprotective Agents - isolation & purification | |
| 650 | 4 | |a Mitochondria - drug effects | |
| 650 | 4 | |a Gynostemma - chemistry | |
| 650 | 4 | |a Cytochromes c - secretion | |
| 650 | 4 | |a Neuroprotective Agents - pharmacology | |
| 650 | 4 | |a Calcium - metabolism | |
| 650 | 4 | |a Gene Expression Regulation - drug effects | |
| 650 | 4 | |a Peptide Fragments - toxicity | |
| 650 | 4 | |a Oxidative Stress - drug effects | |
| 650 | 4 | |a Polysaccharides - pharmacology | |
| 650 | 4 | |a Apoptosis - drug effects | |
| 650 | 4 | |a Signal Transduction - drug effects | |
| 650 | 4 | |a Polysaccharides - chemistry | |
| 650 | 4 | |a Polysaccharides - isolation & purification | |
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| 700 | 1 | |a Xue, Shengxiang |4 oth | |
| 700 | 1 | |a Jia, Dong |4 oth | |
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10.1016/j.carbpol.2014.12.032 doi PQ20160211 (DE-627)OLC1969818115 (DE-599)GBVOLC1969818115 (PRQ)c1583-f71d9f9c47816646f394b8de0cebc71255a5a8239a69bc7b140cfc096854ad810 (KEY)0110347420150000122000000093purificationcharacterizationandneuroprotectiveeffe DE-627 ger DE-627 rakwb eng 540 660 DNB 58.34 bkl 49.25 bkl Rao, Chunguang verfasserin aut Purification, characterization and neuroprotective effects of a polysaccharide from Gynostemma pentaphyllum 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier In the present study, we investigated the neuroprotective effects of GPP1, a purified polysaccharide from Gynostemma pentaphyllum, on Aβ (25-35)-induced neuronal toxicity and explore its potential mechanisms in PC12 cells. The results showed pretreatment with GPP1 prior to Aβ (25-35) exposure significantly protected PC12 cells from Aβ (25-35)-induced cell death, lactate dehydrogenase (LDH) release, DNA damage, intracellular free calcium concentration ([Ca(2+)]i) influx, mitochondrial dysfunction and mitochondrial cytochrome c (Cyt-C) release. In addition, pretreatment with GPP1 also protected PC12 cells against Aβ (25-35)-induced the accumulation of reactive oxygen species (ROS) and lipid peroxidation product MDA, the reduction in glutathione (GSH) level and superoxide dismutase (SOD) activity, the increased Bax/Bcl-2 protein expression ratio and caspase-3 activation. Our findings suggest that GPP1 exerts a neuroprotective effect against Aβ (25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative stress and suppressing the mitochondrial apoptotic pathway. Nutzungsrecht: Copyright © 2015 Elsevier Ltd. All rights reserved. Amyloid beta-Peptides - toxicity Neuroprotective Agents - chemistry Neuroprotective Agents - isolation & purification Mitochondria - drug effects Gynostemma - chemistry Cytochromes c - secretion Neuroprotective Agents - pharmacology Calcium - metabolism Gene Expression Regulation - drug effects Peptide Fragments - toxicity Oxidative Stress - drug effects Polysaccharides - pharmacology Apoptosis - drug effects Signal Transduction - drug effects Polysaccharides - chemistry Polysaccharides - isolation & purification Lei, Jinli oth Xue, Shengxiang oth Jia, Dong oth Enthalten in Carbohydrate polymers Barking, Essex : Applied Science Publ., 1981 122(2015), Seite 93-100 (DE-627)130549746 (DE-600)782631-X (DE-576)481341323 0144-8617 nnns volume:122 year:2015 pages:93-100 http://dx.doi.org/10.1016/j.carbpol.2014.12.032 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25817647 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_4012 58.34 AVZ 49.25 AVZ AR 122 2015 93-100 |
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10.1016/j.carbpol.2014.12.032 doi PQ20160211 (DE-627)OLC1969818115 (DE-599)GBVOLC1969818115 (PRQ)c1583-f71d9f9c47816646f394b8de0cebc71255a5a8239a69bc7b140cfc096854ad810 (KEY)0110347420150000122000000093purificationcharacterizationandneuroprotectiveeffe DE-627 ger DE-627 rakwb eng 540 660 DNB 58.34 bkl 49.25 bkl Rao, Chunguang verfasserin aut Purification, characterization and neuroprotective effects of a polysaccharide from Gynostemma pentaphyllum 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier In the present study, we investigated the neuroprotective effects of GPP1, a purified polysaccharide from Gynostemma pentaphyllum, on Aβ (25-35)-induced neuronal toxicity and explore its potential mechanisms in PC12 cells. The results showed pretreatment with GPP1 prior to Aβ (25-35) exposure significantly protected PC12 cells from Aβ (25-35)-induced cell death, lactate dehydrogenase (LDH) release, DNA damage, intracellular free calcium concentration ([Ca(2+)]i) influx, mitochondrial dysfunction and mitochondrial cytochrome c (Cyt-C) release. In addition, pretreatment with GPP1 also protected PC12 cells against Aβ (25-35)-induced the accumulation of reactive oxygen species (ROS) and lipid peroxidation product MDA, the reduction in glutathione (GSH) level and superoxide dismutase (SOD) activity, the increased Bax/Bcl-2 protein expression ratio and caspase-3 activation. Our findings suggest that GPP1 exerts a neuroprotective effect against Aβ (25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative stress and suppressing the mitochondrial apoptotic pathway. Nutzungsrecht: Copyright © 2015 Elsevier Ltd. All rights reserved. Amyloid beta-Peptides - toxicity Neuroprotective Agents - chemistry Neuroprotective Agents - isolation & purification Mitochondria - drug effects Gynostemma - chemistry Cytochromes c - secretion Neuroprotective Agents - pharmacology Calcium - metabolism Gene Expression Regulation - drug effects Peptide Fragments - toxicity Oxidative Stress - drug effects Polysaccharides - pharmacology Apoptosis - drug effects Signal Transduction - drug effects Polysaccharides - chemistry Polysaccharides - isolation & purification Lei, Jinli oth Xue, Shengxiang oth Jia, Dong oth Enthalten in Carbohydrate polymers Barking, Essex : Applied Science Publ., 1981 122(2015), Seite 93-100 (DE-627)130549746 (DE-600)782631-X (DE-576)481341323 0144-8617 nnns volume:122 year:2015 pages:93-100 http://dx.doi.org/10.1016/j.carbpol.2014.12.032 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25817647 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_4012 58.34 AVZ 49.25 AVZ AR 122 2015 93-100 |
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10.1016/j.carbpol.2014.12.032 doi PQ20160211 (DE-627)OLC1969818115 (DE-599)GBVOLC1969818115 (PRQ)c1583-f71d9f9c47816646f394b8de0cebc71255a5a8239a69bc7b140cfc096854ad810 (KEY)0110347420150000122000000093purificationcharacterizationandneuroprotectiveeffe DE-627 ger DE-627 rakwb eng 540 660 DNB 58.34 bkl 49.25 bkl Rao, Chunguang verfasserin aut Purification, characterization and neuroprotective effects of a polysaccharide from Gynostemma pentaphyllum 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier In the present study, we investigated the neuroprotective effects of GPP1, a purified polysaccharide from Gynostemma pentaphyllum, on Aβ (25-35)-induced neuronal toxicity and explore its potential mechanisms in PC12 cells. The results showed pretreatment with GPP1 prior to Aβ (25-35) exposure significantly protected PC12 cells from Aβ (25-35)-induced cell death, lactate dehydrogenase (LDH) release, DNA damage, intracellular free calcium concentration ([Ca(2+)]i) influx, mitochondrial dysfunction and mitochondrial cytochrome c (Cyt-C) release. In addition, pretreatment with GPP1 also protected PC12 cells against Aβ (25-35)-induced the accumulation of reactive oxygen species (ROS) and lipid peroxidation product MDA, the reduction in glutathione (GSH) level and superoxide dismutase (SOD) activity, the increased Bax/Bcl-2 protein expression ratio and caspase-3 activation. Our findings suggest that GPP1 exerts a neuroprotective effect against Aβ (25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative stress and suppressing the mitochondrial apoptotic pathway. Nutzungsrecht: Copyright © 2015 Elsevier Ltd. All rights reserved. Amyloid beta-Peptides - toxicity Neuroprotective Agents - chemistry Neuroprotective Agents - isolation & purification Mitochondria - drug effects Gynostemma - chemistry Cytochromes c - secretion Neuroprotective Agents - pharmacology Calcium - metabolism Gene Expression Regulation - drug effects Peptide Fragments - toxicity Oxidative Stress - drug effects Polysaccharides - pharmacology Apoptosis - drug effects Signal Transduction - drug effects Polysaccharides - chemistry Polysaccharides - isolation & purification Lei, Jinli oth Xue, Shengxiang oth Jia, Dong oth Enthalten in Carbohydrate polymers Barking, Essex : Applied Science Publ., 1981 122(2015), Seite 93-100 (DE-627)130549746 (DE-600)782631-X (DE-576)481341323 0144-8617 nnns volume:122 year:2015 pages:93-100 http://dx.doi.org/10.1016/j.carbpol.2014.12.032 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25817647 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_4012 58.34 AVZ 49.25 AVZ AR 122 2015 93-100 |
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10.1016/j.carbpol.2014.12.032 doi PQ20160211 (DE-627)OLC1969818115 (DE-599)GBVOLC1969818115 (PRQ)c1583-f71d9f9c47816646f394b8de0cebc71255a5a8239a69bc7b140cfc096854ad810 (KEY)0110347420150000122000000093purificationcharacterizationandneuroprotectiveeffe DE-627 ger DE-627 rakwb eng 540 660 DNB 58.34 bkl 49.25 bkl Rao, Chunguang verfasserin aut Purification, characterization and neuroprotective effects of a polysaccharide from Gynostemma pentaphyllum 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier In the present study, we investigated the neuroprotective effects of GPP1, a purified polysaccharide from Gynostemma pentaphyllum, on Aβ (25-35)-induced neuronal toxicity and explore its potential mechanisms in PC12 cells. The results showed pretreatment with GPP1 prior to Aβ (25-35) exposure significantly protected PC12 cells from Aβ (25-35)-induced cell death, lactate dehydrogenase (LDH) release, DNA damage, intracellular free calcium concentration ([Ca(2+)]i) influx, mitochondrial dysfunction and mitochondrial cytochrome c (Cyt-C) release. In addition, pretreatment with GPP1 also protected PC12 cells against Aβ (25-35)-induced the accumulation of reactive oxygen species (ROS) and lipid peroxidation product MDA, the reduction in glutathione (GSH) level and superoxide dismutase (SOD) activity, the increased Bax/Bcl-2 protein expression ratio and caspase-3 activation. Our findings suggest that GPP1 exerts a neuroprotective effect against Aβ (25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative stress and suppressing the mitochondrial apoptotic pathway. Nutzungsrecht: Copyright © 2015 Elsevier Ltd. All rights reserved. Amyloid beta-Peptides - toxicity Neuroprotective Agents - chemistry Neuroprotective Agents - isolation & purification Mitochondria - drug effects Gynostemma - chemistry Cytochromes c - secretion Neuroprotective Agents - pharmacology Calcium - metabolism Gene Expression Regulation - drug effects Peptide Fragments - toxicity Oxidative Stress - drug effects Polysaccharides - pharmacology Apoptosis - drug effects Signal Transduction - drug effects Polysaccharides - chemistry Polysaccharides - isolation & purification Lei, Jinli oth Xue, Shengxiang oth Jia, Dong oth Enthalten in Carbohydrate polymers Barking, Essex : Applied Science Publ., 1981 122(2015), Seite 93-100 (DE-627)130549746 (DE-600)782631-X (DE-576)481341323 0144-8617 nnns volume:122 year:2015 pages:93-100 http://dx.doi.org/10.1016/j.carbpol.2014.12.032 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25817647 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_4012 58.34 AVZ 49.25 AVZ AR 122 2015 93-100 |
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10.1016/j.carbpol.2014.12.032 doi PQ20160211 (DE-627)OLC1969818115 (DE-599)GBVOLC1969818115 (PRQ)c1583-f71d9f9c47816646f394b8de0cebc71255a5a8239a69bc7b140cfc096854ad810 (KEY)0110347420150000122000000093purificationcharacterizationandneuroprotectiveeffe DE-627 ger DE-627 rakwb eng 540 660 DNB 58.34 bkl 49.25 bkl Rao, Chunguang verfasserin aut Purification, characterization and neuroprotective effects of a polysaccharide from Gynostemma pentaphyllum 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier In the present study, we investigated the neuroprotective effects of GPP1, a purified polysaccharide from Gynostemma pentaphyllum, on Aβ (25-35)-induced neuronal toxicity and explore its potential mechanisms in PC12 cells. The results showed pretreatment with GPP1 prior to Aβ (25-35) exposure significantly protected PC12 cells from Aβ (25-35)-induced cell death, lactate dehydrogenase (LDH) release, DNA damage, intracellular free calcium concentration ([Ca(2+)]i) influx, mitochondrial dysfunction and mitochondrial cytochrome c (Cyt-C) release. In addition, pretreatment with GPP1 also protected PC12 cells against Aβ (25-35)-induced the accumulation of reactive oxygen species (ROS) and lipid peroxidation product MDA, the reduction in glutathione (GSH) level and superoxide dismutase (SOD) activity, the increased Bax/Bcl-2 protein expression ratio and caspase-3 activation. Our findings suggest that GPP1 exerts a neuroprotective effect against Aβ (25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative stress and suppressing the mitochondrial apoptotic pathway. Nutzungsrecht: Copyright © 2015 Elsevier Ltd. All rights reserved. Amyloid beta-Peptides - toxicity Neuroprotective Agents - chemistry Neuroprotective Agents - isolation & purification Mitochondria - drug effects Gynostemma - chemistry Cytochromes c - secretion Neuroprotective Agents - pharmacology Calcium - metabolism Gene Expression Regulation - drug effects Peptide Fragments - toxicity Oxidative Stress - drug effects Polysaccharides - pharmacology Apoptosis - drug effects Signal Transduction - drug effects Polysaccharides - chemistry Polysaccharides - isolation & purification Lei, Jinli oth Xue, Shengxiang oth Jia, Dong oth Enthalten in Carbohydrate polymers Barking, Essex : Applied Science Publ., 1981 122(2015), Seite 93-100 (DE-627)130549746 (DE-600)782631-X (DE-576)481341323 0144-8617 nnns volume:122 year:2015 pages:93-100 http://dx.doi.org/10.1016/j.carbpol.2014.12.032 Volltext http://www.ncbi.nlm.nih.gov/pubmed/25817647 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-TEC SSG-OLC-CHE SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 GBV_ILN_4012 58.34 AVZ 49.25 AVZ AR 122 2015 93-100 |
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540 660 DNB 58.34 bkl 49.25 bkl Purification, characterization and neuroprotective effects of a polysaccharide from Gynostemma pentaphyllum Amyloid beta-Peptides - toxicity Neuroprotective Agents - chemistry Neuroprotective Agents - isolation & purification Mitochondria - drug effects Gynostemma - chemistry Cytochromes c - secretion Neuroprotective Agents - pharmacology Calcium - metabolism Gene Expression Regulation - drug effects Peptide Fragments - toxicity Oxidative Stress - drug effects Polysaccharides - pharmacology Apoptosis - drug effects Signal Transduction - drug effects Polysaccharides - chemistry Polysaccharides - isolation & purification |
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purification, characterization and neuroprotective effects of a polysaccharide from gynostemma pentaphyllum |
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Purification, characterization and neuroprotective effects of a polysaccharide from Gynostemma pentaphyllum |
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In the present study, we investigated the neuroprotective effects of GPP1, a purified polysaccharide from Gynostemma pentaphyllum, on Aβ (25-35)-induced neuronal toxicity and explore its potential mechanisms in PC12 cells. The results showed pretreatment with GPP1 prior to Aβ (25-35) exposure significantly protected PC12 cells from Aβ (25-35)-induced cell death, lactate dehydrogenase (LDH) release, DNA damage, intracellular free calcium concentration ([Ca(2+)]i) influx, mitochondrial dysfunction and mitochondrial cytochrome c (Cyt-C) release. In addition, pretreatment with GPP1 also protected PC12 cells against Aβ (25-35)-induced the accumulation of reactive oxygen species (ROS) and lipid peroxidation product MDA, the reduction in glutathione (GSH) level and superoxide dismutase (SOD) activity, the increased Bax/Bcl-2 protein expression ratio and caspase-3 activation. Our findings suggest that GPP1 exerts a neuroprotective effect against Aβ (25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative stress and suppressing the mitochondrial apoptotic pathway. |
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In the present study, we investigated the neuroprotective effects of GPP1, a purified polysaccharide from Gynostemma pentaphyllum, on Aβ (25-35)-induced neuronal toxicity and explore its potential mechanisms in PC12 cells. The results showed pretreatment with GPP1 prior to Aβ (25-35) exposure significantly protected PC12 cells from Aβ (25-35)-induced cell death, lactate dehydrogenase (LDH) release, DNA damage, intracellular free calcium concentration ([Ca(2+)]i) influx, mitochondrial dysfunction and mitochondrial cytochrome c (Cyt-C) release. In addition, pretreatment with GPP1 also protected PC12 cells against Aβ (25-35)-induced the accumulation of reactive oxygen species (ROS) and lipid peroxidation product MDA, the reduction in glutathione (GSH) level and superoxide dismutase (SOD) activity, the increased Bax/Bcl-2 protein expression ratio and caspase-3 activation. Our findings suggest that GPP1 exerts a neuroprotective effect against Aβ (25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative stress and suppressing the mitochondrial apoptotic pathway. |
| abstract_unstemmed |
In the present study, we investigated the neuroprotective effects of GPP1, a purified polysaccharide from Gynostemma pentaphyllum, on Aβ (25-35)-induced neuronal toxicity and explore its potential mechanisms in PC12 cells. The results showed pretreatment with GPP1 prior to Aβ (25-35) exposure significantly protected PC12 cells from Aβ (25-35)-induced cell death, lactate dehydrogenase (LDH) release, DNA damage, intracellular free calcium concentration ([Ca(2+)]i) influx, mitochondrial dysfunction and mitochondrial cytochrome c (Cyt-C) release. In addition, pretreatment with GPP1 also protected PC12 cells against Aβ (25-35)-induced the accumulation of reactive oxygen species (ROS) and lipid peroxidation product MDA, the reduction in glutathione (GSH) level and superoxide dismutase (SOD) activity, the increased Bax/Bcl-2 protein expression ratio and caspase-3 activation. Our findings suggest that GPP1 exerts a neuroprotective effect against Aβ (25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative stress and suppressing the mitochondrial apoptotic pathway. |
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Purification, characterization and neuroprotective effects of a polysaccharide from Gynostemma pentaphyllum |
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