Highly efficient conversion of superoxide to oxygen using hydrophilic carbon clusters

Many diseases are associated with oxidative stress, which occurs when the production of reactive oxygen species (ROS) overwhelms the scavenging ability of an organism. Here, we evaluated the carbon nanoparticle antioxidant properties of poly(ethylene glycolated) hydrophilic carbon clusters (PEG-HCCs...
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Autor*in:	Roderic H. Fabian [verfasserIn] Brittany R. Bitner Vladimir Berka James M. Tour Thomas A. Kent Daniela C. Marcano Errol L. G. Samuel Gang Wu Ah-Lim Tsai Robia G. Pautler Austin Potter

Format:	Artikel
Sprache:	Englisch

Erschienen:	2015

Rechteinformationen:	Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences

Schlagwörter:	Polyethylene Glycols - chemistry Carbon - chemistry Superoxide Dismutase - metabolism Hydroxyl Radical - chemistry Sodium Hydroxide - chemistry Oxygen - chemistry Hydrogen Peroxide - metabolism Superoxides - chemistry Chemical synthesis Carbon compounds Methods Superoxide Nanoparticles Usage Properties Oxygen Antioxidants Oxidative stress Electrodes Enzymes Polyethylene glycol superoxide dismutase mimetic antioxidant Physical Sciences superoxide hydrophilic carbon clusters carbon nanoparticles

Übergeordnetes Werk:	Enthalten in: Proceedings of the National Academy of Sciences of the United States of America - Washington, DC : NAS, 1877, 112(2015), 8, Seite 2343-2348
Übergeordnetes Werk:	volume:112 ; year:2015 ; number:8 ; pages:2343-2348

Links:	Volltext Link aufrufen Link aufrufen Link aufrufen Link aufrufen

DOI / URN:	10.1073/pnas.1417047112

Katalog-ID:	OLC197025839X

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520			\|a Many diseases are associated with oxidative stress, which occurs when the production of reactive oxygen species (ROS) overwhelms the scavenging ability of an organism. Here, we evaluated the carbon nanoparticle antioxidant properties of poly(ethylene glycolated) hydrophilic carbon clusters (PEG-HCCs) by electron paramagnetic resonance (EPR) spectroscopy, oxygen electrode, and spectrophotometric assays. These carbon nanoparticles have 1 equivalent of stable radical and showed superoxide (O2 (•-)) dismutase-like properties yet were inert to nitric oxide (NO(•)) as well as peroxynitrite (ONOO(-)). Thus, PEG-HCCs can act as selective antioxidants that do not require regeneration by enzymes. Our steady-state kinetic assay using KO2 and direct freeze-trap EPR to follow its decay removed the rate-limiting substrate provision, thus enabling determination of the remarkable intrinsic turnover numbers of O2 (•-) to O2 by PEG-HCCs at >20,000 s(-1). The major products of this catalytic turnover are O2 and H2O2, making the PEG-HCCs a biomimetic superoxide dismutase.
540			\|a Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences
650		4	\|a Polyethylene Glycols - chemistry
650		4	\|a Carbon - chemistry
650		4	\|a Superoxide Dismutase - metabolism
650		4	\|a Hydroxyl Radical - chemistry
650		4	\|a Sodium Hydroxide - chemistry
650		4	\|a Oxygen - chemistry
650		4	\|a Hydrogen Peroxide - metabolism
650		4	\|a Superoxides - chemistry
650		4	\|a Chemical synthesis
650		4	\|a Carbon compounds
650		4	\|a Methods
650		4	\|a Superoxide
650		4	\|a Nanoparticles
650		4	\|a Usage
650		4	\|a Properties
650		4	\|a Oxygen
650		4	\|a Antioxidants
650		4	\|a Oxidative stress
650		4	\|a Electrodes
650		4	\|a Enzymes
650		4	\|a Polyethylene glycol
650		4	\|a superoxide dismutase mimetic
650		4	\|a antioxidant
650		4	\|a Physical Sciences
650		4	\|a superoxide
650		4	\|a hydrophilic carbon clusters
650		4	\|a carbon nanoparticles
700	0		\|a Brittany R. Bitner \|4 oth
700	0		\|a Vladimir Berka \|4 oth
700	0		\|a James M. Tour \|4 oth
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700	0		\|a Daniela C. Marcano \|4 oth
700	0		\|a Errol L. G. Samuel \|4 oth
700	0		\|a Gang Wu \|4 oth
700	0		\|a Ah-Lim Tsai \|4 oth
700	0		\|a Robia G. Pautler \|4 oth
700	0		\|a Austin Potter \|4 oth
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allfields	10.1073/pnas.1417047112 doi PQ20160211 (DE-627)OLC197025839X (DE-599)GBVOLC197025839X (PRQ)c2510-d57399986e02b43d9d195c83827ded92cf9c7f9066a0098bdf4aa57c89b221023 (KEY)0583363920150000112000802343highlyefficientconversionofsuperoxidetooxygenusing DE-627 ger DE-627 rakwb eng 500 DNB 570 AVZ LING fid BIODIV fid Roderic H. Fabian verfasserin aut Highly efficient conversion of superoxide to oxygen using hydrophilic carbon clusters 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Many diseases are associated with oxidative stress, which occurs when the production of reactive oxygen species (ROS) overwhelms the scavenging ability of an organism. Here, we evaluated the carbon nanoparticle antioxidant properties of poly(ethylene glycolated) hydrophilic carbon clusters (PEG-HCCs) by electron paramagnetic resonance (EPR) spectroscopy, oxygen electrode, and spectrophotometric assays. These carbon nanoparticles have 1 equivalent of stable radical and showed superoxide (O2 (•-)) dismutase-like properties yet were inert to nitric oxide (NO(•)) as well as peroxynitrite (ONOO(-)). Thus, PEG-HCCs can act as selective antioxidants that do not require regeneration by enzymes. Our steady-state kinetic assay using KO2 and direct freeze-trap EPR to follow its decay removed the rate-limiting substrate provision, thus enabling determination of the remarkable intrinsic turnover numbers of O2 (•-) to O2 by PEG-HCCs at >20,000 s(-1). The major products of this catalytic turnover are O2 and H2O2, making the PEG-HCCs a biomimetic superoxide dismutase. Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences Polyethylene Glycols - chemistry Carbon - chemistry Superoxide Dismutase - metabolism Hydroxyl Radical - chemistry Sodium Hydroxide - chemistry Oxygen - chemistry Hydrogen Peroxide - metabolism Superoxides - chemistry Chemical synthesis Carbon compounds Methods Superoxide Nanoparticles Usage Properties Oxygen Antioxidants Oxidative stress Electrodes Enzymes Polyethylene glycol superoxide dismutase mimetic antioxidant Physical Sciences superoxide hydrophilic carbon clusters carbon nanoparticles Brittany R. Bitner oth Vladimir Berka oth James M. Tour oth Thomas A. Kent oth Daniela C. Marcano oth Errol L. G. Samuel oth Gang Wu oth Ah-Lim Tsai oth Robia G. Pautler oth Austin Potter oth Enthalten in Proceedings of the National Academy of Sciences of the United States of America Washington, DC : NAS, 1877 112(2015), 8, Seite 2343-2348 (DE-627)129505269 (DE-600)209104-5 (DE-576)014909189 0027-8424 nnns volume:112 year:2015 number:8 pages:2343-2348 http://dx.doi.org/10.1073/pnas.1417047112 Volltext http://www.pnas.org/content/112/8/2343.abstract http://www.ncbi.nlm.nih.gov/pubmed/25675492 http://search.proquest.com/docview/1660767629 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4345556&tool=pmcentrez&rendertype=abstract GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT SSG-OPC-FOR GBV_ILN_40 GBV_ILN_59 AR 112 2015 8 2343-2348
spelling	10.1073/pnas.1417047112 doi PQ20160211 (DE-627)OLC197025839X (DE-599)GBVOLC197025839X (PRQ)c2510-d57399986e02b43d9d195c83827ded92cf9c7f9066a0098bdf4aa57c89b221023 (KEY)0583363920150000112000802343highlyefficientconversionofsuperoxidetooxygenusing DE-627 ger DE-627 rakwb eng 500 DNB 570 AVZ LING fid BIODIV fid Roderic H. Fabian verfasserin aut Highly efficient conversion of superoxide to oxygen using hydrophilic carbon clusters 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Many diseases are associated with oxidative stress, which occurs when the production of reactive oxygen species (ROS) overwhelms the scavenging ability of an organism. Here, we evaluated the carbon nanoparticle antioxidant properties of poly(ethylene glycolated) hydrophilic carbon clusters (PEG-HCCs) by electron paramagnetic resonance (EPR) spectroscopy, oxygen electrode, and spectrophotometric assays. These carbon nanoparticles have 1 equivalent of stable radical and showed superoxide (O2 (•-)) dismutase-like properties yet were inert to nitric oxide (NO(•)) as well as peroxynitrite (ONOO(-)). Thus, PEG-HCCs can act as selective antioxidants that do not require regeneration by enzymes. Our steady-state kinetic assay using KO2 and direct freeze-trap EPR to follow its decay removed the rate-limiting substrate provision, thus enabling determination of the remarkable intrinsic turnover numbers of O2 (•-) to O2 by PEG-HCCs at >20,000 s(-1). The major products of this catalytic turnover are O2 and H2O2, making the PEG-HCCs a biomimetic superoxide dismutase. Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences Polyethylene Glycols - chemistry Carbon - chemistry Superoxide Dismutase - metabolism Hydroxyl Radical - chemistry Sodium Hydroxide - chemistry Oxygen - chemistry Hydrogen Peroxide - metabolism Superoxides - chemistry Chemical synthesis Carbon compounds Methods Superoxide Nanoparticles Usage Properties Oxygen Antioxidants Oxidative stress Electrodes Enzymes Polyethylene glycol superoxide dismutase mimetic antioxidant Physical Sciences superoxide hydrophilic carbon clusters carbon nanoparticles Brittany R. Bitner oth Vladimir Berka oth James M. Tour oth Thomas A. Kent oth Daniela C. Marcano oth Errol L. G. Samuel oth Gang Wu oth Ah-Lim Tsai oth Robia G. Pautler oth Austin Potter oth Enthalten in Proceedings of the National Academy of Sciences of the United States of America Washington, DC : NAS, 1877 112(2015), 8, Seite 2343-2348 (DE-627)129505269 (DE-600)209104-5 (DE-576)014909189 0027-8424 nnns volume:112 year:2015 number:8 pages:2343-2348 http://dx.doi.org/10.1073/pnas.1417047112 Volltext http://www.pnas.org/content/112/8/2343.abstract http://www.ncbi.nlm.nih.gov/pubmed/25675492 http://search.proquest.com/docview/1660767629 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4345556&tool=pmcentrez&rendertype=abstract GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT SSG-OPC-FOR GBV_ILN_40 GBV_ILN_59 AR 112 2015 8 2343-2348
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allfieldsSound	10.1073/pnas.1417047112 doi PQ20160211 (DE-627)OLC197025839X (DE-599)GBVOLC197025839X (PRQ)c2510-d57399986e02b43d9d195c83827ded92cf9c7f9066a0098bdf4aa57c89b221023 (KEY)0583363920150000112000802343highlyefficientconversionofsuperoxidetooxygenusing DE-627 ger DE-627 rakwb eng 500 DNB 570 AVZ LING fid BIODIV fid Roderic H. Fabian verfasserin aut Highly efficient conversion of superoxide to oxygen using hydrophilic carbon clusters 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Many diseases are associated with oxidative stress, which occurs when the production of reactive oxygen species (ROS) overwhelms the scavenging ability of an organism. Here, we evaluated the carbon nanoparticle antioxidant properties of poly(ethylene glycolated) hydrophilic carbon clusters (PEG-HCCs) by electron paramagnetic resonance (EPR) spectroscopy, oxygen electrode, and spectrophotometric assays. These carbon nanoparticles have 1 equivalent of stable radical and showed superoxide (O2 (•-)) dismutase-like properties yet were inert to nitric oxide (NO(•)) as well as peroxynitrite (ONOO(-)). Thus, PEG-HCCs can act as selective antioxidants that do not require regeneration by enzymes. Our steady-state kinetic assay using KO2 and direct freeze-trap EPR to follow its decay removed the rate-limiting substrate provision, thus enabling determination of the remarkable intrinsic turnover numbers of O2 (•-) to O2 by PEG-HCCs at >20,000 s(-1). The major products of this catalytic turnover are O2 and H2O2, making the PEG-HCCs a biomimetic superoxide dismutase. Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences Polyethylene Glycols - chemistry Carbon - chemistry Superoxide Dismutase - metabolism Hydroxyl Radical - chemistry Sodium Hydroxide - chemistry Oxygen - chemistry Hydrogen Peroxide - metabolism Superoxides - chemistry Chemical synthesis Carbon compounds Methods Superoxide Nanoparticles Usage Properties Oxygen Antioxidants Oxidative stress Electrodes Enzymes Polyethylene glycol superoxide dismutase mimetic antioxidant Physical Sciences superoxide hydrophilic carbon clusters carbon nanoparticles Brittany R. Bitner oth Vladimir Berka oth James M. Tour oth Thomas A. Kent oth Daniela C. Marcano oth Errol L. G. Samuel oth Gang Wu oth Ah-Lim Tsai oth Robia G. Pautler oth Austin Potter oth Enthalten in Proceedings of the National Academy of Sciences of the United States of America Washington, DC : NAS, 1877 112(2015), 8, Seite 2343-2348 (DE-627)129505269 (DE-600)209104-5 (DE-576)014909189 0027-8424 nnns volume:112 year:2015 number:8 pages:2343-2348 http://dx.doi.org/10.1073/pnas.1417047112 Volltext http://www.pnas.org/content/112/8/2343.abstract http://www.ncbi.nlm.nih.gov/pubmed/25675492 http://search.proquest.com/docview/1660767629 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4345556&tool=pmcentrez&rendertype=abstract GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT SSG-OPC-FOR GBV_ILN_40 GBV_ILN_59 AR 112 2015 8 2343-2348
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topic_facet	Polyethylene Glycols - chemistry Carbon - chemistry Superoxide Dismutase - metabolism Hydroxyl Radical - chemistry Sodium Hydroxide - chemistry Oxygen - chemistry Hydrogen Peroxide - metabolism Superoxides - chemistry Chemical synthesis Carbon compounds Methods Superoxide Nanoparticles Usage Properties Oxygen Antioxidants Oxidative stress Electrodes Enzymes Polyethylene glycol superoxide dismutase mimetic antioxidant Physical Sciences superoxide hydrophilic carbon clusters carbon nanoparticles
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Fabian</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Highly efficient conversion of superoxide to oxygen using hydrophilic carbon clusters</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2015</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">ohne Hilfsmittel zu benutzen</subfield><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Band</subfield><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Many diseases are associated with oxidative stress, which occurs when the production of reactive oxygen species (ROS) overwhelms the scavenging ability of an organism. 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author	Roderic H. Fabian
spellingShingle	Roderic H. Fabian ddc 500 ddc 570 fid LING fid BIODIV misc Polyethylene Glycols - chemistry misc Carbon - chemistry misc Superoxide Dismutase - metabolism misc Hydroxyl Radical - chemistry misc Sodium Hydroxide - chemistry misc Oxygen - chemistry misc Hydrogen Peroxide - metabolism misc Superoxides - chemistry misc Chemical synthesis misc Carbon compounds misc Methods misc Superoxide misc Nanoparticles misc Usage misc Properties misc Oxygen misc Antioxidants misc Oxidative stress misc Electrodes misc Enzymes misc Polyethylene glycol misc superoxide dismutase mimetic misc antioxidant misc Physical Sciences misc superoxide misc hydrophilic carbon clusters misc carbon nanoparticles Highly efficient conversion of superoxide to oxygen using hydrophilic carbon clusters
authorStr	Roderic H. Fabian
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topic_title	500 DNB 570 AVZ LING fid BIODIV fid Highly efficient conversion of superoxide to oxygen using hydrophilic carbon clusters Polyethylene Glycols - chemistry Carbon - chemistry Superoxide Dismutase - metabolism Hydroxyl Radical - chemistry Sodium Hydroxide - chemistry Oxygen - chemistry Hydrogen Peroxide - metabolism Superoxides - chemistry Chemical synthesis Carbon compounds Methods Superoxide Nanoparticles Usage Properties Oxygen Antioxidants Oxidative stress Electrodes Enzymes Polyethylene glycol superoxide dismutase mimetic antioxidant Physical Sciences superoxide hydrophilic carbon clusters carbon nanoparticles
topic	ddc 500 ddc 570 fid LING fid BIODIV misc Polyethylene Glycols - chemistry misc Carbon - chemistry misc Superoxide Dismutase - metabolism misc Hydroxyl Radical - chemistry misc Sodium Hydroxide - chemistry misc Oxygen - chemistry misc Hydrogen Peroxide - metabolism misc Superoxides - chemistry misc Chemical synthesis misc Carbon compounds misc Methods misc Superoxide misc Nanoparticles misc Usage misc Properties misc Oxygen misc Antioxidants misc Oxidative stress misc Electrodes misc Enzymes misc Polyethylene glycol misc superoxide dismutase mimetic misc antioxidant misc Physical Sciences misc superoxide misc hydrophilic carbon clusters misc carbon nanoparticles
topic_unstemmed	ddc 500 ddc 570 fid LING fid BIODIV misc Polyethylene Glycols - chemistry misc Carbon - chemistry misc Superoxide Dismutase - metabolism misc Hydroxyl Radical - chemistry misc Sodium Hydroxide - chemistry misc Oxygen - chemistry misc Hydrogen Peroxide - metabolism misc Superoxides - chemistry misc Chemical synthesis misc Carbon compounds misc Methods misc Superoxide misc Nanoparticles misc Usage misc Properties misc Oxygen misc Antioxidants misc Oxidative stress misc Electrodes misc Enzymes misc Polyethylene glycol misc superoxide dismutase mimetic misc antioxidant misc Physical Sciences misc superoxide misc hydrophilic carbon clusters misc carbon nanoparticles
topic_browse	ddc 500 ddc 570 fid LING fid BIODIV misc Polyethylene Glycols - chemistry misc Carbon - chemistry misc Superoxide Dismutase - metabolism misc Hydroxyl Radical - chemistry misc Sodium Hydroxide - chemistry misc Oxygen - chemistry misc Hydrogen Peroxide - metabolism misc Superoxides - chemistry misc Chemical synthesis misc Carbon compounds misc Methods misc Superoxide misc Nanoparticles misc Usage misc Properties misc Oxygen misc Antioxidants misc Oxidative stress misc Electrodes misc Enzymes misc Polyethylene glycol misc superoxide dismutase mimetic misc antioxidant misc Physical Sciences misc superoxide misc hydrophilic carbon clusters misc carbon nanoparticles
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title	Highly efficient conversion of superoxide to oxygen using hydrophilic carbon clusters
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title_full	Highly efficient conversion of superoxide to oxygen using hydrophilic carbon clusters
author_sort	Roderic H. Fabian
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title_sort	highly efficient conversion of superoxide to oxygen using hydrophilic carbon clusters
title_auth	Highly efficient conversion of superoxide to oxygen using hydrophilic carbon clusters
abstract	Many diseases are associated with oxidative stress, which occurs when the production of reactive oxygen species (ROS) overwhelms the scavenging ability of an organism. Here, we evaluated the carbon nanoparticle antioxidant properties of poly(ethylene glycolated) hydrophilic carbon clusters (PEG-HCCs) by electron paramagnetic resonance (EPR) spectroscopy, oxygen electrode, and spectrophotometric assays. These carbon nanoparticles have 1 equivalent of stable radical and showed superoxide (O2 (•-)) dismutase-like properties yet were inert to nitric oxide (NO(•)) as well as peroxynitrite (ONOO(-)). Thus, PEG-HCCs can act as selective antioxidants that do not require regeneration by enzymes. Our steady-state kinetic assay using KO2 and direct freeze-trap EPR to follow its decay removed the rate-limiting substrate provision, thus enabling determination of the remarkable intrinsic turnover numbers of O2 (•-) to O2 by PEG-HCCs at >20,000 s(-1). The major products of this catalytic turnover are O2 and H2O2, making the PEG-HCCs a biomimetic superoxide dismutase.
abstractGer	Many diseases are associated with oxidative stress, which occurs when the production of reactive oxygen species (ROS) overwhelms the scavenging ability of an organism. Here, we evaluated the carbon nanoparticle antioxidant properties of poly(ethylene glycolated) hydrophilic carbon clusters (PEG-HCCs) by electron paramagnetic resonance (EPR) spectroscopy, oxygen electrode, and spectrophotometric assays. These carbon nanoparticles have 1 equivalent of stable radical and showed superoxide (O2 (•-)) dismutase-like properties yet were inert to nitric oxide (NO(•)) as well as peroxynitrite (ONOO(-)). Thus, PEG-HCCs can act as selective antioxidants that do not require regeneration by enzymes. Our steady-state kinetic assay using KO2 and direct freeze-trap EPR to follow its decay removed the rate-limiting substrate provision, thus enabling determination of the remarkable intrinsic turnover numbers of O2 (•-) to O2 by PEG-HCCs at >20,000 s(-1). The major products of this catalytic turnover are O2 and H2O2, making the PEG-HCCs a biomimetic superoxide dismutase.
abstract_unstemmed	Many diseases are associated with oxidative stress, which occurs when the production of reactive oxygen species (ROS) overwhelms the scavenging ability of an organism. Here, we evaluated the carbon nanoparticle antioxidant properties of poly(ethylene glycolated) hydrophilic carbon clusters (PEG-HCCs) by electron paramagnetic resonance (EPR) spectroscopy, oxygen electrode, and spectrophotometric assays. These carbon nanoparticles have 1 equivalent of stable radical and showed superoxide (O2 (•-)) dismutase-like properties yet were inert to nitric oxide (NO(•)) as well as peroxynitrite (ONOO(-)). Thus, PEG-HCCs can act as selective antioxidants that do not require regeneration by enzymes. Our steady-state kinetic assay using KO2 and direct freeze-trap EPR to follow its decay removed the rate-limiting substrate provision, thus enabling determination of the remarkable intrinsic turnover numbers of O2 (•-) to O2 by PEG-HCCs at >20,000 s(-1). The major products of this catalytic turnover are O2 and H2O2, making the PEG-HCCs a biomimetic superoxide dismutase.
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT SSG-OPC-FOR GBV_ILN_40 GBV_ILN_59
container_issue	8
title_short	Highly efficient conversion of superoxide to oxygen using hydrophilic carbon clusters
url	http://dx.doi.org/10.1073/pnas.1417047112 http://www.pnas.org/content/112/8/2343.abstract http://www.ncbi.nlm.nih.gov/pubmed/25675492 http://search.proquest.com/docview/1660767629 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4345556&tool=pmcentrez&rendertype=abstract
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author2	Brittany R. Bitner Vladimir Berka James M. Tour Thomas A. Kent Daniela C. Marcano Errol L. G. Samuel Gang Wu Ah-Lim Tsai Robia G. Pautler Austin Potter
author2Str	Brittany R. Bitner Vladimir Berka James M. Tour Thomas A. Kent Daniela C. Marcano Errol L. G. Samuel Gang Wu Ah-Lim Tsai Robia G. Pautler Austin Potter
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up_date	2024-07-03T14:29:21.966Z
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Fabian</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Highly efficient conversion of superoxide to oxygen using hydrophilic carbon clusters</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2015</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">ohne Hilfsmittel zu benutzen</subfield><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Band</subfield><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Many diseases are associated with oxidative stress, which occurs when the production of reactive oxygen species (ROS) overwhelms the scavenging ability of an organism. Here, we evaluated the carbon nanoparticle antioxidant properties of poly(ethylene glycolated) hydrophilic carbon clusters (PEG-HCCs) by electron paramagnetic resonance (EPR) spectroscopy, oxygen electrode, and spectrophotometric assays. These carbon nanoparticles have 1 equivalent of stable radical and showed superoxide (O2 (•-)) dismutase-like properties yet were inert to nitric oxide (NO(•)) as well as peroxynitrite (ONOO(-)). Thus, PEG-HCCs can act as selective antioxidants that do not require regeneration by enzymes. Our steady-state kinetic assay using KO2 and direct freeze-trap EPR to follow its decay removed the rate-limiting substrate provision, thus enabling determination of the remarkable intrinsic turnover numbers of O2 (•-) to O2 by PEG-HCCs at >20,000 s(-1). The major products of this catalytic turnover are O2 and H2O2, making the PEG-HCCs a biomimetic superoxide dismutase.</subfield></datafield><datafield tag="540" ind1=" " ind2=" "><subfield code="a">Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Polyethylene Glycols - chemistry</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Carbon - chemistry</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Superoxide Dismutase - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Hydroxyl Radical - chemistry</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Sodium Hydroxide - chemistry</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Oxygen - chemistry</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Hydrogen Peroxide - metabolism</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Superoxides - chemistry</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Chemical synthesis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Carbon compounds</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Methods</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Superoxide</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Nanoparticles</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Usage</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Properties</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Oxygen</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Antioxidants</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Oxidative stress</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Electrodes</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Enzymes</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Polyethylene glycol</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">superoxide dismutase mimetic</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">antioxidant</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Physical Sciences</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">superoxide</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">hydrophilic carbon clusters</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">carbon nanoparticles</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Brittany R. Bitner</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Vladimir Berka</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">James M. Tour</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Thomas A. Kent</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Daniela C. Marcano</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Errol L. G. Samuel</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gang Wu</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ah-Lim Tsai</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Robia G. Pautler</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Austin Potter</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Proceedings of the National Academy of Sciences of the United States of America</subfield><subfield code="d">Washington, DC : NAS, 1877</subfield><subfield code="g">112(2015), 8, Seite 2343-2348</subfield><subfield code="w">(DE-627)129505269</subfield><subfield code="w">(DE-600)209104-5</subfield><subfield code="w">(DE-576)014909189</subfield><subfield code="x">0027-8424</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:112</subfield><subfield code="g">year:2015</subfield><subfield code="g">number:8</subfield><subfield code="g">pages:2343-2348</subfield></datafield><datafield tag="856" ind1="4" ind2="1"><subfield code="u">http://dx.doi.org/10.1073/pnas.1417047112</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">http://www.pnas.org/content/112/8/2343.abstract</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">http://www.ncbi.nlm.nih.gov/pubmed/25675492</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">http://search.proquest.com/docview/1660767629</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4345556&tool=pmcentrez&rendertype=abstract</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_OLC</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">FID-LING</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">FID-BIODIV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHY</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-CHE</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-MAT</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-FOR</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-DE-84</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OPC-MAT</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OPC-FOR</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_59</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">112</subfield><subfield code="j">2015</subfield><subfield code="e">8</subfield><subfield code="h">2343-2348</subfield></datafield></record></collection>
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