Transgenic songbirds with suppressed or enhanced activity of CREB transcription factor
Songbirds postnatally develop their skill to utter and to perceive a vocal signal for communication. How genetic and environmental influences act in concert to regulate the development of such skill is not fully understood. Here, we report the phenotype of transgenic songbirds with altered intrinsic...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Dai Watanabe [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Rechteinformationen: |
Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences |
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| Schlagwörter: |
Cyclic AMP Response Element-Binding Protein - metabolism Vocalization, Animal - physiology |
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| Übergeordnetes Werk: |
Enthalten in: Proceedings of the National Academy of Sciences of the United States of America - Washington, DC : NAS, 1877, 112(2015), 24, Seite 7599-7604 |
|---|---|
| Übergeordnetes Werk: |
volume:112 ; year:2015 ; number:24 ; pages:7599-7604 |
| Links: |
|---|
| DOI / URN: |
10.1073/pnas.1413484112 |
|---|
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| 520 | |a Songbirds postnatally develop their skill to utter and to perceive a vocal signal for communication. How genetic and environmental influences act in concert to regulate the development of such skill is not fully understood. Here, we report the phenotype of transgenic songbirds with altered intrinsic activity of cAMP response element-binding protein (CREB) transcription factor. By viral vector-mediated modification of genomic DNA, we established germ line-transmitted lines of zebra finches, which exhibited enhanced or suppressed activity of CREB. Although intrinsically acquired vocalizations or their hearing ability were not affected, the transgenic birds showed reduced vocal learning quality of their own songs and impaired audio-memory formation against conspecific songs. These results thus demonstrate that appropriate activity of CREB is necessary for the postnatal acquisition of learned behavior in songbirds, and the CREB transgenic birds offer a unique opportunity to separately manipulate both genetic and environmental factors that impinge on the postnatal song learning. | ||
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10.1073/pnas.1413484112 doi PQ20160211 (DE-627)OLC1970271566 (DE-599)GBVOLC1970271566 (PRQ)c2929-1dce9df6c719fb30a94b144433eba5bf083d2cb4e1a9214ad6306550349bf5d03 (KEY)0583363920150000112002407599transgenicsongbirdswithsuppressedorenhancedactivit DE-627 ger DE-627 rakwb eng 500 DNB 570 AVZ LING fid BIODIV fid Dai Watanabe verfasserin aut Transgenic songbirds with suppressed or enhanced activity of CREB transcription factor 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Songbirds postnatally develop their skill to utter and to perceive a vocal signal for communication. How genetic and environmental influences act in concert to regulate the development of such skill is not fully understood. Here, we report the phenotype of transgenic songbirds with altered intrinsic activity of cAMP response element-binding protein (CREB) transcription factor. By viral vector-mediated modification of genomic DNA, we established germ line-transmitted lines of zebra finches, which exhibited enhanced or suppressed activity of CREB. Although intrinsically acquired vocalizations or their hearing ability were not affected, the transgenic birds showed reduced vocal learning quality of their own songs and impaired audio-memory formation against conspecific songs. These results thus demonstrate that appropriate activity of CREB is necessary for the postnatal acquisition of learned behavior in songbirds, and the CREB transgenic birds offer a unique opportunity to separately manipulate both genetic and environmental factors that impinge on the postnatal song learning. Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences Avian Proteins - genetics Finches - physiology Cyclic AMP Response Element-Binding Protein - metabolism Finches - metabolism Learning - physiology Vocalization, Animal - physiology Behavior, Animal - physiology Memory - physiology Brain - metabolism Avian Proteins - metabolism Finches - genetics Cyclic AMP Response Element-Binding Protein - genetics Embryonic development Transcription factors Physiological aspects Genetic aspects Deoxyribonucleic acid--DNA Animal memory Genotype & phenotype Birds Animal communication Kentaro Abe oth Sumiko Matsui oth Enthalten in Proceedings of the National Academy of Sciences of the United States of America Washington, DC : NAS, 1877 112(2015), 24, Seite 7599-7604 (DE-627)129505269 (DE-600)209104-5 (DE-576)014909189 0027-8424 nnns volume:112 year:2015 number:24 pages:7599-7604 http://dx.doi.org/10.1073/pnas.1413484112 Volltext http://www.pnas.org/content/112/24/7599.abstract http://www.ncbi.nlm.nih.gov/pubmed/26048905 http://search.proquest.com/docview/1691075107 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT SSG-OPC-FOR GBV_ILN_40 GBV_ILN_59 AR 112 2015 24 7599-7604 |
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10.1073/pnas.1413484112 doi PQ20160211 (DE-627)OLC1970271566 (DE-599)GBVOLC1970271566 (PRQ)c2929-1dce9df6c719fb30a94b144433eba5bf083d2cb4e1a9214ad6306550349bf5d03 (KEY)0583363920150000112002407599transgenicsongbirdswithsuppressedorenhancedactivit DE-627 ger DE-627 rakwb eng 500 DNB 570 AVZ LING fid BIODIV fid Dai Watanabe verfasserin aut Transgenic songbirds with suppressed or enhanced activity of CREB transcription factor 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Songbirds postnatally develop their skill to utter and to perceive a vocal signal for communication. How genetic and environmental influences act in concert to regulate the development of such skill is not fully understood. Here, we report the phenotype of transgenic songbirds with altered intrinsic activity of cAMP response element-binding protein (CREB) transcription factor. By viral vector-mediated modification of genomic DNA, we established germ line-transmitted lines of zebra finches, which exhibited enhanced or suppressed activity of CREB. Although intrinsically acquired vocalizations or their hearing ability were not affected, the transgenic birds showed reduced vocal learning quality of their own songs and impaired audio-memory formation against conspecific songs. These results thus demonstrate that appropriate activity of CREB is necessary for the postnatal acquisition of learned behavior in songbirds, and the CREB transgenic birds offer a unique opportunity to separately manipulate both genetic and environmental factors that impinge on the postnatal song learning. Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences Avian Proteins - genetics Finches - physiology Cyclic AMP Response Element-Binding Protein - metabolism Finches - metabolism Learning - physiology Vocalization, Animal - physiology Behavior, Animal - physiology Memory - physiology Brain - metabolism Avian Proteins - metabolism Finches - genetics Cyclic AMP Response Element-Binding Protein - genetics Embryonic development Transcription factors Physiological aspects Genetic aspects Deoxyribonucleic acid--DNA Animal memory Genotype & phenotype Birds Animal communication Kentaro Abe oth Sumiko Matsui oth Enthalten in Proceedings of the National Academy of Sciences of the United States of America Washington, DC : NAS, 1877 112(2015), 24, Seite 7599-7604 (DE-627)129505269 (DE-600)209104-5 (DE-576)014909189 0027-8424 nnns volume:112 year:2015 number:24 pages:7599-7604 http://dx.doi.org/10.1073/pnas.1413484112 Volltext http://www.pnas.org/content/112/24/7599.abstract http://www.ncbi.nlm.nih.gov/pubmed/26048905 http://search.proquest.com/docview/1691075107 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT SSG-OPC-FOR GBV_ILN_40 GBV_ILN_59 AR 112 2015 24 7599-7604 |
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10.1073/pnas.1413484112 doi PQ20160211 (DE-627)OLC1970271566 (DE-599)GBVOLC1970271566 (PRQ)c2929-1dce9df6c719fb30a94b144433eba5bf083d2cb4e1a9214ad6306550349bf5d03 (KEY)0583363920150000112002407599transgenicsongbirdswithsuppressedorenhancedactivit DE-627 ger DE-627 rakwb eng 500 DNB 570 AVZ LING fid BIODIV fid Dai Watanabe verfasserin aut Transgenic songbirds with suppressed or enhanced activity of CREB transcription factor 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Songbirds postnatally develop their skill to utter and to perceive a vocal signal for communication. How genetic and environmental influences act in concert to regulate the development of such skill is not fully understood. Here, we report the phenotype of transgenic songbirds with altered intrinsic activity of cAMP response element-binding protein (CREB) transcription factor. By viral vector-mediated modification of genomic DNA, we established germ line-transmitted lines of zebra finches, which exhibited enhanced or suppressed activity of CREB. Although intrinsically acquired vocalizations or their hearing ability were not affected, the transgenic birds showed reduced vocal learning quality of their own songs and impaired audio-memory formation against conspecific songs. These results thus demonstrate that appropriate activity of CREB is necessary for the postnatal acquisition of learned behavior in songbirds, and the CREB transgenic birds offer a unique opportunity to separately manipulate both genetic and environmental factors that impinge on the postnatal song learning. Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences Avian Proteins - genetics Finches - physiology Cyclic AMP Response Element-Binding Protein - metabolism Finches - metabolism Learning - physiology Vocalization, Animal - physiology Behavior, Animal - physiology Memory - physiology Brain - metabolism Avian Proteins - metabolism Finches - genetics Cyclic AMP Response Element-Binding Protein - genetics Embryonic development Transcription factors Physiological aspects Genetic aspects Deoxyribonucleic acid--DNA Animal memory Genotype & phenotype Birds Animal communication Kentaro Abe oth Sumiko Matsui oth Enthalten in Proceedings of the National Academy of Sciences of the United States of America Washington, DC : NAS, 1877 112(2015), 24, Seite 7599-7604 (DE-627)129505269 (DE-600)209104-5 (DE-576)014909189 0027-8424 nnns volume:112 year:2015 number:24 pages:7599-7604 http://dx.doi.org/10.1073/pnas.1413484112 Volltext http://www.pnas.org/content/112/24/7599.abstract http://www.ncbi.nlm.nih.gov/pubmed/26048905 http://search.proquest.com/docview/1691075107 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT SSG-OPC-FOR GBV_ILN_40 GBV_ILN_59 AR 112 2015 24 7599-7604 |
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Songbirds postnatally develop their skill to utter and to perceive a vocal signal for communication. How genetic and environmental influences act in concert to regulate the development of such skill is not fully understood. Here, we report the phenotype of transgenic songbirds with altered intrinsic activity of cAMP response element-binding protein (CREB) transcription factor. By viral vector-mediated modification of genomic DNA, we established germ line-transmitted lines of zebra finches, which exhibited enhanced or suppressed activity of CREB. Although intrinsically acquired vocalizations or their hearing ability were not affected, the transgenic birds showed reduced vocal learning quality of their own songs and impaired audio-memory formation against conspecific songs. These results thus demonstrate that appropriate activity of CREB is necessary for the postnatal acquisition of learned behavior in songbirds, and the CREB transgenic birds offer a unique opportunity to separately manipulate both genetic and environmental factors that impinge on the postnatal song learning. |
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Songbirds postnatally develop their skill to utter and to perceive a vocal signal for communication. How genetic and environmental influences act in concert to regulate the development of such skill is not fully understood. Here, we report the phenotype of transgenic songbirds with altered intrinsic activity of cAMP response element-binding protein (CREB) transcription factor. By viral vector-mediated modification of genomic DNA, we established germ line-transmitted lines of zebra finches, which exhibited enhanced or suppressed activity of CREB. Although intrinsically acquired vocalizations or their hearing ability were not affected, the transgenic birds showed reduced vocal learning quality of their own songs and impaired audio-memory formation against conspecific songs. These results thus demonstrate that appropriate activity of CREB is necessary for the postnatal acquisition of learned behavior in songbirds, and the CREB transgenic birds offer a unique opportunity to separately manipulate both genetic and environmental factors that impinge on the postnatal song learning. |
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Songbirds postnatally develop their skill to utter and to perceive a vocal signal for communication. How genetic and environmental influences act in concert to regulate the development of such skill is not fully understood. Here, we report the phenotype of transgenic songbirds with altered intrinsic activity of cAMP response element-binding protein (CREB) transcription factor. By viral vector-mediated modification of genomic DNA, we established germ line-transmitted lines of zebra finches, which exhibited enhanced or suppressed activity of CREB. Although intrinsically acquired vocalizations or their hearing ability were not affected, the transgenic birds showed reduced vocal learning quality of their own songs and impaired audio-memory formation against conspecific songs. These results thus demonstrate that appropriate activity of CREB is necessary for the postnatal acquisition of learned behavior in songbirds, and the CREB transgenic birds offer a unique opportunity to separately manipulate both genetic and environmental factors that impinge on the postnatal song learning. |
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