Notes on the role of dynamic DNA methylation in mammalian development
It has been nearly 40 y since it was suggested that genomic methylation patterns could be transmitted via maintenance methylation during S phase and might play a role in the dynamic regulation of gene expression during development [Holliday R, Pugh JE (1975) Science 187(4173):226–232; Riggs AD (1975...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Mathieu Boulard [verfasserIn] |
|---|
| Format: |
Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Rechteinformationen: |
Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences |
|---|
| Übergeordnetes Werk: |
Enthalten in: Proceedings of the National Academy of Sciences of the United States of America - Washington, DC : NAS, 1877, 112(2015), 22, Seite 6796-6799 |
|---|---|
| Übergeordnetes Werk: |
volume:112 ; year:2015 ; number:22 ; pages:6796-6799 |
| Links: |
|---|
| DOI / URN: |
10.1073/pnas.1415301111 |
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| 520 | |a It has been nearly 40 y since it was suggested that genomic methylation patterns could be transmitted via maintenance methylation during S phase and might play a role in the dynamic regulation of gene expression during development [Holliday R, Pugh JE (1975) Science 187(4173):226–232; Riggs AD (1975) Cytogenet Cell Genet 14(1):9–25]. This revolutionary proposal was justified by “... our almost complete ignorance of the mechanism for the unfolding of the genetic program during development” that prevailed at the time. Many correlations between transcriptional activation and demethylation have since been reported, but causation has not been demonstrated and to date there is no reasonable proof of the existence of a complex biochemical system that activates and represses genes via reversible DNA methylation. Such a system would supplement or replace the conserved web of transcription factors that regulate cellular differentiation in organisms that have unmethylated genomes (such as Caenorhaditis elegans and the Dipteran insects) and those that methylate their genomes. DNA methylation does have essential roles in irreversible promoter silencing, as in the monoallelic expression of imprinted genes, in the silencing of transposons, and in X chromosome inactivation in female mammals. Rather than reinforcing or replacing regulatory pathways that are conserved between organisms that have either methylated or unmethylated genomes, DNA methylation endows genomes with the ability to subject specific sequences to irreversible transcriptional silencing even in the presence of all of the factors required for their expression, an ability that is generally unavailable to organisms that have unmethylated genomes. | ||
| 540 | |a Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences | ||
| 650 | 4 | |a DNA Methylation - physiology | |
| 650 | 4 | |a Promoter Regions, Genetic - genetics | |
| 650 | 4 | |a X Chromosome Inactivation - genetics | |
| 650 | 4 | |a X Chromosome Inactivation - physiology | |
| 650 | 4 | |a Mammals - growth & development | |
| 650 | 4 | |a Gene Expression Regulation, Developmental - physiology | |
| 650 | 4 | |a Epigenesis, Genetic - physiology | |
| 650 | 4 | |a Research | |
| 650 | 4 | |a Methylation | |
| 650 | 4 | |a Animal development | |
| 650 | 4 | |a Genetic aspects | |
| 650 | 4 | |a Physiological aspects | |
| 650 | 4 | |a DNA methylation | |
| 650 | 4 | |a Gene expression | |
| 650 | 4 | |a Genomes | |
| 650 | 4 | |a Biochemistry | |
| 650 | 4 | |a Mammals | |
| 650 | 4 | |a Genomics | |
| 700 | 0 | |a John R. Edwards |4 oth | |
| 700 | 0 | |a Timothy H. Bestor |4 oth | |
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10.1073/pnas.1415301111 doi PQ20160211 (DE-627)OLC1970271930 (DE-599)GBVOLC1970271930 (PRQ)c2502-91ed59ee77a6c10604b4c1fc878a75ffd53db1341959e3d96ffba7abe5d477553 (KEY)0583363920150000112002206796notesontheroleofdynamicdnamethylationinmammaliande DE-627 ger DE-627 rakwb eng 500 DNB 570 AVZ LING fid BIODIV fid Mathieu Boulard verfasserin aut Notes on the role of dynamic DNA methylation in mammalian development 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier It has been nearly 40 y since it was suggested that genomic methylation patterns could be transmitted via maintenance methylation during S phase and might play a role in the dynamic regulation of gene expression during development [Holliday R, Pugh JE (1975) Science 187(4173):226–232; Riggs AD (1975) Cytogenet Cell Genet 14(1):9–25]. This revolutionary proposal was justified by “... our almost complete ignorance of the mechanism for the unfolding of the genetic program during development” that prevailed at the time. Many correlations between transcriptional activation and demethylation have since been reported, but causation has not been demonstrated and to date there is no reasonable proof of the existence of a complex biochemical system that activates and represses genes via reversible DNA methylation. Such a system would supplement or replace the conserved web of transcription factors that regulate cellular differentiation in organisms that have unmethylated genomes (such as Caenorhaditis elegans and the Dipteran insects) and those that methylate their genomes. DNA methylation does have essential roles in irreversible promoter silencing, as in the monoallelic expression of imprinted genes, in the silencing of transposons, and in X chromosome inactivation in female mammals. Rather than reinforcing or replacing regulatory pathways that are conserved between organisms that have either methylated or unmethylated genomes, DNA methylation endows genomes with the ability to subject specific sequences to irreversible transcriptional silencing even in the presence of all of the factors required for their expression, an ability that is generally unavailable to organisms that have unmethylated genomes. Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences DNA Methylation - physiology Promoter Regions, Genetic - genetics X Chromosome Inactivation - genetics X Chromosome Inactivation - physiology Mammals - growth & development Gene Expression Regulation, Developmental - physiology Epigenesis, Genetic - physiology Research Methylation Animal development Genetic aspects Physiological aspects DNA methylation Gene expression Genomes Biochemistry Mammals Genomics John R. Edwards oth Timothy H. Bestor oth Enthalten in Proceedings of the National Academy of Sciences of the United States of America Washington, DC : NAS, 1877 112(2015), 22, Seite 6796-6799 (DE-627)129505269 (DE-600)209104-5 (DE-576)014909189 0027-8424 nnns volume:112 year:2015 number:22 pages:6796-6799 http://dx.doi.org/10.1073/pnas.1415301111 Volltext http://www.pnas.org/content/112/22/6796.abstract http://www.ncbi.nlm.nih.gov/pubmed/25368180 http://search.proquest.com/docview/1688664503 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT SSG-OPC-FOR GBV_ILN_40 GBV_ILN_59 AR 112 2015 22 6796-6799 |
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10.1073/pnas.1415301111 doi PQ20160211 (DE-627)OLC1970271930 (DE-599)GBVOLC1970271930 (PRQ)c2502-91ed59ee77a6c10604b4c1fc878a75ffd53db1341959e3d96ffba7abe5d477553 (KEY)0583363920150000112002206796notesontheroleofdynamicdnamethylationinmammaliande DE-627 ger DE-627 rakwb eng 500 DNB 570 AVZ LING fid BIODIV fid Mathieu Boulard verfasserin aut Notes on the role of dynamic DNA methylation in mammalian development 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier It has been nearly 40 y since it was suggested that genomic methylation patterns could be transmitted via maintenance methylation during S phase and might play a role in the dynamic regulation of gene expression during development [Holliday R, Pugh JE (1975) Science 187(4173):226–232; Riggs AD (1975) Cytogenet Cell Genet 14(1):9–25]. This revolutionary proposal was justified by “... our almost complete ignorance of the mechanism for the unfolding of the genetic program during development” that prevailed at the time. Many correlations between transcriptional activation and demethylation have since been reported, but causation has not been demonstrated and to date there is no reasonable proof of the existence of a complex biochemical system that activates and represses genes via reversible DNA methylation. Such a system would supplement or replace the conserved web of transcription factors that regulate cellular differentiation in organisms that have unmethylated genomes (such as Caenorhaditis elegans and the Dipteran insects) and those that methylate their genomes. DNA methylation does have essential roles in irreversible promoter silencing, as in the monoallelic expression of imprinted genes, in the silencing of transposons, and in X chromosome inactivation in female mammals. Rather than reinforcing or replacing regulatory pathways that are conserved between organisms that have either methylated or unmethylated genomes, DNA methylation endows genomes with the ability to subject specific sequences to irreversible transcriptional silencing even in the presence of all of the factors required for their expression, an ability that is generally unavailable to organisms that have unmethylated genomes. Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences DNA Methylation - physiology Promoter Regions, Genetic - genetics X Chromosome Inactivation - genetics X Chromosome Inactivation - physiology Mammals - growth & development Gene Expression Regulation, Developmental - physiology Epigenesis, Genetic - physiology Research Methylation Animal development Genetic aspects Physiological aspects DNA methylation Gene expression Genomes Biochemistry Mammals Genomics John R. Edwards oth Timothy H. Bestor oth Enthalten in Proceedings of the National Academy of Sciences of the United States of America Washington, DC : NAS, 1877 112(2015), 22, Seite 6796-6799 (DE-627)129505269 (DE-600)209104-5 (DE-576)014909189 0027-8424 nnns volume:112 year:2015 number:22 pages:6796-6799 http://dx.doi.org/10.1073/pnas.1415301111 Volltext http://www.pnas.org/content/112/22/6796.abstract http://www.ncbi.nlm.nih.gov/pubmed/25368180 http://search.proquest.com/docview/1688664503 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT SSG-OPC-FOR GBV_ILN_40 GBV_ILN_59 AR 112 2015 22 6796-6799 |
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10.1073/pnas.1415301111 doi PQ20160211 (DE-627)OLC1970271930 (DE-599)GBVOLC1970271930 (PRQ)c2502-91ed59ee77a6c10604b4c1fc878a75ffd53db1341959e3d96ffba7abe5d477553 (KEY)0583363920150000112002206796notesontheroleofdynamicdnamethylationinmammaliande DE-627 ger DE-627 rakwb eng 500 DNB 570 AVZ LING fid BIODIV fid Mathieu Boulard verfasserin aut Notes on the role of dynamic DNA methylation in mammalian development 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier It has been nearly 40 y since it was suggested that genomic methylation patterns could be transmitted via maintenance methylation during S phase and might play a role in the dynamic regulation of gene expression during development [Holliday R, Pugh JE (1975) Science 187(4173):226–232; Riggs AD (1975) Cytogenet Cell Genet 14(1):9–25]. This revolutionary proposal was justified by “... our almost complete ignorance of the mechanism for the unfolding of the genetic program during development” that prevailed at the time. Many correlations between transcriptional activation and demethylation have since been reported, but causation has not been demonstrated and to date there is no reasonable proof of the existence of a complex biochemical system that activates and represses genes via reversible DNA methylation. Such a system would supplement or replace the conserved web of transcription factors that regulate cellular differentiation in organisms that have unmethylated genomes (such as Caenorhaditis elegans and the Dipteran insects) and those that methylate their genomes. DNA methylation does have essential roles in irreversible promoter silencing, as in the monoallelic expression of imprinted genes, in the silencing of transposons, and in X chromosome inactivation in female mammals. Rather than reinforcing or replacing regulatory pathways that are conserved between organisms that have either methylated or unmethylated genomes, DNA methylation endows genomes with the ability to subject specific sequences to irreversible transcriptional silencing even in the presence of all of the factors required for their expression, an ability that is generally unavailable to organisms that have unmethylated genomes. Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences DNA Methylation - physiology Promoter Regions, Genetic - genetics X Chromosome Inactivation - genetics X Chromosome Inactivation - physiology Mammals - growth & development Gene Expression Regulation, Developmental - physiology Epigenesis, Genetic - physiology Research Methylation Animal development Genetic aspects Physiological aspects DNA methylation Gene expression Genomes Biochemistry Mammals Genomics John R. Edwards oth Timothy H. Bestor oth Enthalten in Proceedings of the National Academy of Sciences of the United States of America Washington, DC : NAS, 1877 112(2015), 22, Seite 6796-6799 (DE-627)129505269 (DE-600)209104-5 (DE-576)014909189 0027-8424 nnns volume:112 year:2015 number:22 pages:6796-6799 http://dx.doi.org/10.1073/pnas.1415301111 Volltext http://www.pnas.org/content/112/22/6796.abstract http://www.ncbi.nlm.nih.gov/pubmed/25368180 http://search.proquest.com/docview/1688664503 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT SSG-OPC-FOR GBV_ILN_40 GBV_ILN_59 AR 112 2015 22 6796-6799 |
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Notes on the role of dynamic DNA methylation in mammalian development |
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It has been nearly 40 y since it was suggested that genomic methylation patterns could be transmitted via maintenance methylation during S phase and might play a role in the dynamic regulation of gene expression during development [Holliday R, Pugh JE (1975) Science 187(4173):226–232; Riggs AD (1975) Cytogenet Cell Genet 14(1):9–25]. This revolutionary proposal was justified by “... our almost complete ignorance of the mechanism for the unfolding of the genetic program during development” that prevailed at the time. Many correlations between transcriptional activation and demethylation have since been reported, but causation has not been demonstrated and to date there is no reasonable proof of the existence of a complex biochemical system that activates and represses genes via reversible DNA methylation. Such a system would supplement or replace the conserved web of transcription factors that regulate cellular differentiation in organisms that have unmethylated genomes (such as Caenorhaditis elegans and the Dipteran insects) and those that methylate their genomes. DNA methylation does have essential roles in irreversible promoter silencing, as in the monoallelic expression of imprinted genes, in the silencing of transposons, and in X chromosome inactivation in female mammals. Rather than reinforcing or replacing regulatory pathways that are conserved between organisms that have either methylated or unmethylated genomes, DNA methylation endows genomes with the ability to subject specific sequences to irreversible transcriptional silencing even in the presence of all of the factors required for their expression, an ability that is generally unavailable to organisms that have unmethylated genomes. |
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It has been nearly 40 y since it was suggested that genomic methylation patterns could be transmitted via maintenance methylation during S phase and might play a role in the dynamic regulation of gene expression during development [Holliday R, Pugh JE (1975) Science 187(4173):226–232; Riggs AD (1975) Cytogenet Cell Genet 14(1):9–25]. This revolutionary proposal was justified by “... our almost complete ignorance of the mechanism for the unfolding of the genetic program during development” that prevailed at the time. Many correlations between transcriptional activation and demethylation have since been reported, but causation has not been demonstrated and to date there is no reasonable proof of the existence of a complex biochemical system that activates and represses genes via reversible DNA methylation. Such a system would supplement or replace the conserved web of transcription factors that regulate cellular differentiation in organisms that have unmethylated genomes (such as Caenorhaditis elegans and the Dipteran insects) and those that methylate their genomes. DNA methylation does have essential roles in irreversible promoter silencing, as in the monoallelic expression of imprinted genes, in the silencing of transposons, and in X chromosome inactivation in female mammals. Rather than reinforcing or replacing regulatory pathways that are conserved between organisms that have either methylated or unmethylated genomes, DNA methylation endows genomes with the ability to subject specific sequences to irreversible transcriptional silencing even in the presence of all of the factors required for their expression, an ability that is generally unavailable to organisms that have unmethylated genomes. |
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It has been nearly 40 y since it was suggested that genomic methylation patterns could be transmitted via maintenance methylation during S phase and might play a role in the dynamic regulation of gene expression during development [Holliday R, Pugh JE (1975) Science 187(4173):226–232; Riggs AD (1975) Cytogenet Cell Genet 14(1):9–25]. This revolutionary proposal was justified by “... our almost complete ignorance of the mechanism for the unfolding of the genetic program during development” that prevailed at the time. Many correlations between transcriptional activation and demethylation have since been reported, but causation has not been demonstrated and to date there is no reasonable proof of the existence of a complex biochemical system that activates and represses genes via reversible DNA methylation. Such a system would supplement or replace the conserved web of transcription factors that regulate cellular differentiation in organisms that have unmethylated genomes (such as Caenorhaditis elegans and the Dipteran insects) and those that methylate their genomes. DNA methylation does have essential roles in irreversible promoter silencing, as in the monoallelic expression of imprinted genes, in the silencing of transposons, and in X chromosome inactivation in female mammals. Rather than reinforcing or replacing regulatory pathways that are conserved between organisms that have either methylated or unmethylated genomes, DNA methylation endows genomes with the ability to subject specific sequences to irreversible transcriptional silencing even in the presence of all of the factors required for their expression, an ability that is generally unavailable to organisms that have unmethylated genomes. |
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