Disruption of hippocampal–prefrontal cortex activity by dopamine D2R-dependent LTD of NMDAR transmission

Functional connectivity between the hippocampus and prefrontal cortex (PFC) is essential for associative recognition memory and working memory. Disruption of hippocampal-PFC synchrony occurs in schizophrenia, which is characterized by hypofunction of NMDA receptor (NMDAR)-mediated transmission. We d...
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Autor*in:	Zafar Iqbal Bashir [verfasserIn] Paul James Banks Jon Thomas Brown Amelia Caroline Burroughs Elizabeth Clea Warburton Gareth Robert Isaac Barker

Format:	Artikel
Sprache:	Englisch

Erschienen:	2015

Rechteinformationen:	Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences

Schlagwörter:	Receptors, N-Methyl-D-Aspartate - metabolism Receptors, Dopamine D2 - physiology Hippocampus - physiology Prefrontal Cortex - physiology Long-Term Synaptic Depression - physiology Hippocampus (Brain) Observations Dopamine Prefrontal cortex Physiological aspects Neural transmission Brain Schizophrenia Memory Recognition medial prefrontal cortex long-term depression NMDA receptor hypofunction D2R schizophrenia Biological Sciences

Übergeordnetes Werk:	Enthalten in: Proceedings of the National Academy of Sciences of the United States of America - Washington, DC : NAS, 1877, 112(2015), 35, Seite 11096-11101
Übergeordnetes Werk:	volume:112 ; year:2015 ; number:35 ; pages:11096-11101

Links:	Volltext Link aufrufen Link aufrufen Link aufrufen Link aufrufen

DOI / URN:	10.1073/pnas.1512064112

Katalog-ID:	OLC1970283866

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spelling	10.1073/pnas.1512064112 doi PQ20160211 (DE-627)OLC1970283866 (DE-599)GBVOLC1970283866 (PRQ)c3064-72450124a6c4ff6329e10aef437696f8f0a0a555e3e61d6cf230744f28decac90 (KEY)0583363920150000112003511096disruptionofhippocampalprefrontalcortexactivitybyd DE-627 ger DE-627 rakwb eng 500 DNB 570 AVZ LING fid BIODIV fid Zafar Iqbal Bashir verfasserin aut Disruption of hippocampal–prefrontal cortex activity by dopamine D2R-dependent LTD of NMDAR transmission 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Functional connectivity between the hippocampus and prefrontal cortex (PFC) is essential for associative recognition memory and working memory. Disruption of hippocampal-PFC synchrony occurs in schizophrenia, which is characterized by hypofunction of NMDA receptor (NMDAR)-mediated transmission. We demonstrate that activity of dopamine D2-like receptors (D2Rs) leads selectively to long-term depression (LTD) of hippocampal-PFC NMDAR-mediated synaptic transmission. We show that dopamine-dependent LTD of NMDAR-mediated transmission profoundly disrupts normal synaptic transmission between hippocampus and PFC. These results show how dopaminergic activation induces long-term hypofunction of NMDARs, which can contribute to disordered functional connectivity, a characteristic that is a hallmark of psychiatric disorders such as schizophrenia. Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences Receptors, N-Methyl-D-Aspartate - metabolism Receptors, Dopamine D2 - physiology Hippocampus - physiology Prefrontal Cortex - physiology Long-Term Synaptic Depression - physiology Hippocampus (Brain) Observations Dopamine Prefrontal cortex Physiological aspects Neural transmission Brain Schizophrenia Memory Recognition medial prefrontal cortex long-term depression NMDA receptor hypofunction D2R schizophrenia Biological Sciences Paul James Banks oth Jon Thomas Brown oth Amelia Caroline Burroughs oth Elizabeth Clea Warburton oth Gareth Robert Isaac Barker oth Enthalten in Proceedings of the National Academy of Sciences of the United States of America Washington, DC : NAS, 1877 112(2015), 35, Seite 11096-11101 (DE-627)129505269 (DE-600)209104-5 (DE-576)014909189 0027-8424 nnns volume:112 year:2015 number:35 pages:11096-11101 http://dx.doi.org/10.1073/pnas.1512064112 Volltext http://www.pnas.org/content/112/35/11096.abstract http://www.ncbi.nlm.nih.gov/pubmed/26286993 http://search.proquest.com/docview/1711093547 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4568284&tool=pmcentrez&rendertype=abstract GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT SSG-OPC-FOR GBV_ILN_40 GBV_ILN_59 AR 112 2015 35 11096-11101
allfields_unstemmed	10.1073/pnas.1512064112 doi PQ20160211 (DE-627)OLC1970283866 (DE-599)GBVOLC1970283866 (PRQ)c3064-72450124a6c4ff6329e10aef437696f8f0a0a555e3e61d6cf230744f28decac90 (KEY)0583363920150000112003511096disruptionofhippocampalprefrontalcortexactivitybyd DE-627 ger DE-627 rakwb eng 500 DNB 570 AVZ LING fid BIODIV fid Zafar Iqbal Bashir verfasserin aut Disruption of hippocampal–prefrontal cortex activity by dopamine D2R-dependent LTD of NMDAR transmission 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Functional connectivity between the hippocampus and prefrontal cortex (PFC) is essential for associative recognition memory and working memory. Disruption of hippocampal-PFC synchrony occurs in schizophrenia, which is characterized by hypofunction of NMDA receptor (NMDAR)-mediated transmission. We demonstrate that activity of dopamine D2-like receptors (D2Rs) leads selectively to long-term depression (LTD) of hippocampal-PFC NMDAR-mediated synaptic transmission. We show that dopamine-dependent LTD of NMDAR-mediated transmission profoundly disrupts normal synaptic transmission between hippocampus and PFC. These results show how dopaminergic activation induces long-term hypofunction of NMDARs, which can contribute to disordered functional connectivity, a characteristic that is a hallmark of psychiatric disorders such as schizophrenia. Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences Receptors, N-Methyl-D-Aspartate - metabolism Receptors, Dopamine D2 - physiology Hippocampus - physiology Prefrontal Cortex - physiology Long-Term Synaptic Depression - physiology Hippocampus (Brain) Observations Dopamine Prefrontal cortex Physiological aspects Neural transmission Brain Schizophrenia Memory Recognition medial prefrontal cortex long-term depression NMDA receptor hypofunction D2R schizophrenia Biological Sciences Paul James Banks oth Jon Thomas Brown oth Amelia Caroline Burroughs oth Elizabeth Clea Warburton oth Gareth Robert Isaac Barker oth Enthalten in Proceedings of the National Academy of Sciences of the United States of America Washington, DC : NAS, 1877 112(2015), 35, Seite 11096-11101 (DE-627)129505269 (DE-600)209104-5 (DE-576)014909189 0027-8424 nnns volume:112 year:2015 number:35 pages:11096-11101 http://dx.doi.org/10.1073/pnas.1512064112 Volltext http://www.pnas.org/content/112/35/11096.abstract http://www.ncbi.nlm.nih.gov/pubmed/26286993 http://search.proquest.com/docview/1711093547 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4568284&tool=pmcentrez&rendertype=abstract GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT SSG-OPC-FOR GBV_ILN_40 GBV_ILN_59 AR 112 2015 35 11096-11101
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author	Zafar Iqbal Bashir
spellingShingle	Zafar Iqbal Bashir ddc 500 ddc 570 fid LING fid BIODIV misc Receptors, N-Methyl-D-Aspartate - metabolism misc Receptors, Dopamine D2 - physiology misc Hippocampus - physiology misc Prefrontal Cortex - physiology misc Long-Term Synaptic Depression - physiology misc Hippocampus (Brain) misc Observations misc Dopamine misc Prefrontal cortex misc Physiological aspects misc Neural transmission misc Brain misc Schizophrenia misc Memory misc Recognition misc medial prefrontal cortex misc long-term depression misc NMDA receptor hypofunction misc D2R misc schizophrenia misc Biological Sciences Disruption of hippocampal–prefrontal cortex activity by dopamine D2R-dependent LTD of NMDAR transmission
authorStr	Zafar Iqbal Bashir
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topic_title	500 DNB 570 AVZ LING fid BIODIV fid Disruption of hippocampal–prefrontal cortex activity by dopamine D2R-dependent LTD of NMDAR transmission Receptors, N-Methyl-D-Aspartate - metabolism Receptors, Dopamine D2 - physiology Hippocampus - physiology Prefrontal Cortex - physiology Long-Term Synaptic Depression - physiology Hippocampus (Brain) Observations Dopamine Prefrontal cortex Physiological aspects Neural transmission Brain Schizophrenia Memory Recognition medial prefrontal cortex long-term depression NMDA receptor hypofunction D2R schizophrenia Biological Sciences
topic	ddc 500 ddc 570 fid LING fid BIODIV misc Receptors, N-Methyl-D-Aspartate - metabolism misc Receptors, Dopamine D2 - physiology misc Hippocampus - physiology misc Prefrontal Cortex - physiology misc Long-Term Synaptic Depression - physiology misc Hippocampus (Brain) misc Observations misc Dopamine misc Prefrontal cortex misc Physiological aspects misc Neural transmission misc Brain misc Schizophrenia misc Memory misc Recognition misc medial prefrontal cortex misc long-term depression misc NMDA receptor hypofunction misc D2R misc schizophrenia misc Biological Sciences
topic_unstemmed	ddc 500 ddc 570 fid LING fid BIODIV misc Receptors, N-Methyl-D-Aspartate - metabolism misc Receptors, Dopamine D2 - physiology misc Hippocampus - physiology misc Prefrontal Cortex - physiology misc Long-Term Synaptic Depression - physiology misc Hippocampus (Brain) misc Observations misc Dopamine misc Prefrontal cortex misc Physiological aspects misc Neural transmission misc Brain misc Schizophrenia misc Memory misc Recognition misc medial prefrontal cortex misc long-term depression misc NMDA receptor hypofunction misc D2R misc schizophrenia misc Biological Sciences
topic_browse	ddc 500 ddc 570 fid LING fid BIODIV misc Receptors, N-Methyl-D-Aspartate - metabolism misc Receptors, Dopamine D2 - physiology misc Hippocampus - physiology misc Prefrontal Cortex - physiology misc Long-Term Synaptic Depression - physiology misc Hippocampus (Brain) misc Observations misc Dopamine misc Prefrontal cortex misc Physiological aspects misc Neural transmission misc Brain misc Schizophrenia misc Memory misc Recognition misc medial prefrontal cortex misc long-term depression misc NMDA receptor hypofunction misc D2R misc schizophrenia misc Biological Sciences
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title	Disruption of hippocampal–prefrontal cortex activity by dopamine D2R-dependent LTD of NMDAR transmission
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title_full	Disruption of hippocampal–prefrontal cortex activity by dopamine D2R-dependent LTD of NMDAR transmission
author_sort	Zafar Iqbal Bashir
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title_sort	disruption of hippocampal–prefrontal cortex activity by dopamine d2r-dependent ltd of nmdar transmission
title_auth	Disruption of hippocampal–prefrontal cortex activity by dopamine D2R-dependent LTD of NMDAR transmission
abstract	Functional connectivity between the hippocampus and prefrontal cortex (PFC) is essential for associative recognition memory and working memory. Disruption of hippocampal-PFC synchrony occurs in schizophrenia, which is characterized by hypofunction of NMDA receptor (NMDAR)-mediated transmission. We demonstrate that activity of dopamine D2-like receptors (D2Rs) leads selectively to long-term depression (LTD) of hippocampal-PFC NMDAR-mediated synaptic transmission. We show that dopamine-dependent LTD of NMDAR-mediated transmission profoundly disrupts normal synaptic transmission between hippocampus and PFC. These results show how dopaminergic activation induces long-term hypofunction of NMDARs, which can contribute to disordered functional connectivity, a characteristic that is a hallmark of psychiatric disorders such as schizophrenia.
abstractGer	Functional connectivity between the hippocampus and prefrontal cortex (PFC) is essential for associative recognition memory and working memory. Disruption of hippocampal-PFC synchrony occurs in schizophrenia, which is characterized by hypofunction of NMDA receptor (NMDAR)-mediated transmission. We demonstrate that activity of dopamine D2-like receptors (D2Rs) leads selectively to long-term depression (LTD) of hippocampal-PFC NMDAR-mediated synaptic transmission. We show that dopamine-dependent LTD of NMDAR-mediated transmission profoundly disrupts normal synaptic transmission between hippocampus and PFC. These results show how dopaminergic activation induces long-term hypofunction of NMDARs, which can contribute to disordered functional connectivity, a characteristic that is a hallmark of psychiatric disorders such as schizophrenia.
abstract_unstemmed	Functional connectivity between the hippocampus and prefrontal cortex (PFC) is essential for associative recognition memory and working memory. Disruption of hippocampal-PFC synchrony occurs in schizophrenia, which is characterized by hypofunction of NMDA receptor (NMDAR)-mediated transmission. We demonstrate that activity of dopamine D2-like receptors (D2Rs) leads selectively to long-term depression (LTD) of hippocampal-PFC NMDAR-mediated synaptic transmission. We show that dopamine-dependent LTD of NMDAR-mediated transmission profoundly disrupts normal synaptic transmission between hippocampus and PFC. These results show how dopaminergic activation induces long-term hypofunction of NMDARs, which can contribute to disordered functional connectivity, a characteristic that is a hallmark of psychiatric disorders such as schizophrenia.
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container_issue	35
title_short	Disruption of hippocampal–prefrontal cortex activity by dopamine D2R-dependent LTD of NMDAR transmission
url	http://dx.doi.org/10.1073/pnas.1512064112 http://www.pnas.org/content/112/35/11096.abstract http://www.ncbi.nlm.nih.gov/pubmed/26286993 http://search.proquest.com/docview/1711093547 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=4568284&tool=pmcentrez&rendertype=abstract
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up_date	2024-07-03T14:38:45.881Z
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