The B-cell antigen receptor integrates adaptive and innate immune signals
B cells respond to antigens by engagement of their B-cell antigen receptor (BCR) and of coreceptors through which signals from helper T cells or pathogen-associated molecular patterns are delivered. We show that the proliferative response of B cells to the latter stimuli is controlled by BCR-depende...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ari Waisman [verfasserIn] |
|---|
| Format: |
Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Rechteinformationen: |
Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences |
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| Schlagwörter: |
Signal Transduction - immunology Adaptive Immunity - immunology Cell Proliferation - physiology Receptors, Antigen, B-Cell - immunology |
|---|
| Übergeordnetes Werk: |
Enthalten in: Proceedings of the National Academy of Sciences of the United States of America - Washington, DC : NAS, 1877, 112(2015), 39, Seite 12145-12150 |
|---|---|
| Übergeordnetes Werk: |
volume:112 ; year:2015 ; number:39 ; pages:12145-12150 |
| Links: |
|---|
| DOI / URN: |
10.1073/pnas.1516428112 |
|---|
| Katalog-ID: |
OLC1970284692 |
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| 520 | |a B cells respond to antigens by engagement of their B-cell antigen receptor (BCR) and of coreceptors through which signals from helper T cells or pathogen-associated molecular patterns are delivered. We show that the proliferative response of B cells to the latter stimuli is controlled by BCR-dependent activation of phosphoinositidyl 3-kinase (PI-3K) signaling. Glycogen synthase kinase 3β and Foxo1 are two PI-3K-regulated targets that play important roles, but to different extents, depending on the specific mitogen. These results suggest a model for integrating signals from the innate and the adaptive immune systems in the control of the B-cell immune response. | ||
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10.1073/pnas.1516428112 doi PQ20160211 (DE-627)OLC1970284692 (DE-599)GBVOLC1970284692 (PRQ)c2515-da062269e28d307c289261edd13dc3a1cc344b1411ecdf32ce03308c198a43b80 (KEY)0583363920150000112003912145bcellantigenreceptorintegratesadaptiveandinnateimm DE-627 ger DE-627 rakwb eng 500 DNB 570 AVZ LING fid BIODIV fid Ari Waisman verfasserin aut The B-cell antigen receptor integrates adaptive and innate immune signals 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier B cells respond to antigens by engagement of their B-cell antigen receptor (BCR) and of coreceptors through which signals from helper T cells or pathogen-associated molecular patterns are delivered. We show that the proliferative response of B cells to the latter stimuli is controlled by BCR-dependent activation of phosphoinositidyl 3-kinase (PI-3K) signaling. Glycogen synthase kinase 3β and Foxo1 are two PI-3K-regulated targets that play important roles, but to different extents, depending on the specific mitogen. These results suggest a model for integrating signals from the innate and the adaptive immune systems in the control of the B-cell immune response. Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences Signal Transduction - immunology Immunity, Innate - immunology Adaptive Immunity - immunology DNA Primers - genetics Cell Proliferation - physiology Receptors, Antigen, B-Cell - immunology Cell Survival - immunology Phosphatidylinositol 3-Kinases - metabolism Observations Immune response Antigens Phosphotransferases Health aspects B cells Kinases Biosynthesis T cell receptors Immunology Signal transduction Klaus Rajewsky oth Emmanuel Derudder oth Lakshmi Srinivasan oth Kevin L. Otipoby oth Andrew Franklin oth Enthalten in Proceedings of the National Academy of Sciences of the United States of America Washington, DC : NAS, 1877 112(2015), 39, Seite 12145-12150 (DE-627)129505269 (DE-600)209104-5 (DE-576)014909189 0027-8424 nnns volume:112 year:2015 number:39 pages:12145-12150 http://dx.doi.org/10.1073/pnas.1516428112 Volltext http://www.pnas.org/content/112/39/12145.abstract http://www.ncbi.nlm.nih.gov/pubmed/26371314 http://search.proquest.com/docview/1720066973 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT SSG-OPC-FOR GBV_ILN_40 GBV_ILN_59 AR 112 2015 39 12145-12150 |
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10.1073/pnas.1516428112 doi PQ20160211 (DE-627)OLC1970284692 (DE-599)GBVOLC1970284692 (PRQ)c2515-da062269e28d307c289261edd13dc3a1cc344b1411ecdf32ce03308c198a43b80 (KEY)0583363920150000112003912145bcellantigenreceptorintegratesadaptiveandinnateimm DE-627 ger DE-627 rakwb eng 500 DNB 570 AVZ LING fid BIODIV fid Ari Waisman verfasserin aut The B-cell antigen receptor integrates adaptive and innate immune signals 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier B cells respond to antigens by engagement of their B-cell antigen receptor (BCR) and of coreceptors through which signals from helper T cells or pathogen-associated molecular patterns are delivered. We show that the proliferative response of B cells to the latter stimuli is controlled by BCR-dependent activation of phosphoinositidyl 3-kinase (PI-3K) signaling. Glycogen synthase kinase 3β and Foxo1 are two PI-3K-regulated targets that play important roles, but to different extents, depending on the specific mitogen. These results suggest a model for integrating signals from the innate and the adaptive immune systems in the control of the B-cell immune response. Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences Signal Transduction - immunology Immunity, Innate - immunology Adaptive Immunity - immunology DNA Primers - genetics Cell Proliferation - physiology Receptors, Antigen, B-Cell - immunology Cell Survival - immunology Phosphatidylinositol 3-Kinases - metabolism Observations Immune response Antigens Phosphotransferases Health aspects B cells Kinases Biosynthesis T cell receptors Immunology Signal transduction Klaus Rajewsky oth Emmanuel Derudder oth Lakshmi Srinivasan oth Kevin L. Otipoby oth Andrew Franklin oth Enthalten in Proceedings of the National Academy of Sciences of the United States of America Washington, DC : NAS, 1877 112(2015), 39, Seite 12145-12150 (DE-627)129505269 (DE-600)209104-5 (DE-576)014909189 0027-8424 nnns volume:112 year:2015 number:39 pages:12145-12150 http://dx.doi.org/10.1073/pnas.1516428112 Volltext http://www.pnas.org/content/112/39/12145.abstract http://www.ncbi.nlm.nih.gov/pubmed/26371314 http://search.proquest.com/docview/1720066973 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT SSG-OPC-FOR GBV_ILN_40 GBV_ILN_59 AR 112 2015 39 12145-12150 |
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10.1073/pnas.1516428112 doi PQ20160211 (DE-627)OLC1970284692 (DE-599)GBVOLC1970284692 (PRQ)c2515-da062269e28d307c289261edd13dc3a1cc344b1411ecdf32ce03308c198a43b80 (KEY)0583363920150000112003912145bcellantigenreceptorintegratesadaptiveandinnateimm DE-627 ger DE-627 rakwb eng 500 DNB 570 AVZ LING fid BIODIV fid Ari Waisman verfasserin aut The B-cell antigen receptor integrates adaptive and innate immune signals 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier B cells respond to antigens by engagement of their B-cell antigen receptor (BCR) and of coreceptors through which signals from helper T cells or pathogen-associated molecular patterns are delivered. We show that the proliferative response of B cells to the latter stimuli is controlled by BCR-dependent activation of phosphoinositidyl 3-kinase (PI-3K) signaling. Glycogen synthase kinase 3β and Foxo1 are two PI-3K-regulated targets that play important roles, but to different extents, depending on the specific mitogen. These results suggest a model for integrating signals from the innate and the adaptive immune systems in the control of the B-cell immune response. Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences Signal Transduction - immunology Immunity, Innate - immunology Adaptive Immunity - immunology DNA Primers - genetics Cell Proliferation - physiology Receptors, Antigen, B-Cell - immunology Cell Survival - immunology Phosphatidylinositol 3-Kinases - metabolism Observations Immune response Antigens Phosphotransferases Health aspects B cells Kinases Biosynthesis T cell receptors Immunology Signal transduction Klaus Rajewsky oth Emmanuel Derudder oth Lakshmi Srinivasan oth Kevin L. Otipoby oth Andrew Franklin oth Enthalten in Proceedings of the National Academy of Sciences of the United States of America Washington, DC : NAS, 1877 112(2015), 39, Seite 12145-12150 (DE-627)129505269 (DE-600)209104-5 (DE-576)014909189 0027-8424 nnns volume:112 year:2015 number:39 pages:12145-12150 http://dx.doi.org/10.1073/pnas.1516428112 Volltext http://www.pnas.org/content/112/39/12145.abstract http://www.ncbi.nlm.nih.gov/pubmed/26371314 http://search.proquest.com/docview/1720066973 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT SSG-OPC-FOR GBV_ILN_40 GBV_ILN_59 AR 112 2015 39 12145-12150 |
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The B-cell antigen receptor integrates adaptive and innate immune signals |
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b-cell antigen receptor integrates adaptive and innate immune signals |
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The B-cell antigen receptor integrates adaptive and innate immune signals |
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B cells respond to antigens by engagement of their B-cell antigen receptor (BCR) and of coreceptors through which signals from helper T cells or pathogen-associated molecular patterns are delivered. We show that the proliferative response of B cells to the latter stimuli is controlled by BCR-dependent activation of phosphoinositidyl 3-kinase (PI-3K) signaling. Glycogen synthase kinase 3β and Foxo1 are two PI-3K-regulated targets that play important roles, but to different extents, depending on the specific mitogen. These results suggest a model for integrating signals from the innate and the adaptive immune systems in the control of the B-cell immune response. |
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B cells respond to antigens by engagement of their B-cell antigen receptor (BCR) and of coreceptors through which signals from helper T cells or pathogen-associated molecular patterns are delivered. We show that the proliferative response of B cells to the latter stimuli is controlled by BCR-dependent activation of phosphoinositidyl 3-kinase (PI-3K) signaling. Glycogen synthase kinase 3β and Foxo1 are two PI-3K-regulated targets that play important roles, but to different extents, depending on the specific mitogen. These results suggest a model for integrating signals from the innate and the adaptive immune systems in the control of the B-cell immune response. |
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B cells respond to antigens by engagement of their B-cell antigen receptor (BCR) and of coreceptors through which signals from helper T cells or pathogen-associated molecular patterns are delivered. We show that the proliferative response of B cells to the latter stimuli is controlled by BCR-dependent activation of phosphoinositidyl 3-kinase (PI-3K) signaling. Glycogen synthase kinase 3β and Foxo1 are two PI-3K-regulated targets that play important roles, but to different extents, depending on the specific mitogen. These results suggest a model for integrating signals from the innate and the adaptive immune systems in the control of the B-cell immune response. |
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The B-cell antigen receptor integrates adaptive and innate immune signals |
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