HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
Increased expression of CD47 has been reported to enable cancer cells to evade phagocytosis by macrophages and to promote the cancer stem cell phenotype, but the molecular mechanisms regulating CD47 expression have not been determined. Here we report that hypoxia-inducible factor 1 (HIF-1) directly...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Daniele M. Gilkes [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Rechteinformationen: |
Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Proceedings of the National Academy of Sciences of the United States of America - Washington, DC : NAS, 1877, 112(2015), 45, Seite E6215-E6223 |
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| Übergeordnetes Werk: |
volume:112 ; year:2015 ; number:45 ; pages:E6215-E6223 |
| Links: |
|---|
| DOI / URN: |
10.1073/pnas.1520032112 |
|---|
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OLC1970290986 |
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| 520 | |a Increased expression of CD47 has been reported to enable cancer cells to evade phagocytosis by macrophages and to promote the cancer stem cell phenotype, but the molecular mechanisms regulating CD47 expression have not been determined. Here we report that hypoxia-inducible factor 1 (HIF-1) directly activates transcription of the CD47 gene in hypoxic breast cancer cells. Knockdown of HIF activity or CD47 expression increased the phagocytosis of breast cancer cells by bone marrow-derived macrophages. CD47 expression was increased in mammosphere cultures, which are enriched for cancer stem cells, and CD47 deficiency led to cancer stem cell depletion. Analysis of datasets derived from thousands of patients with breast cancer revealed that CD47 expression was correlated with HIF target gene expression and with patient mortality. Thus, CD47 expression contributes to the lethal breast cancer phenotype that is mediated by HIF-1. | ||
| 540 | |a Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences | ||
| 650 | 4 | |a Gene expression | |
| 650 | 4 | |a Complications and side effects | |
| 650 | 4 | |a Influence | |
| 650 | 4 | |a Analysis | |
| 650 | 4 | |a Care and treatment | |
| 650 | 4 | |a Breast cancer | |
| 650 | 4 | |a Research | |
| 650 | 4 | |a Transcriptional coactivators | |
| 650 | 4 | |a Stem cell research | |
| 650 | 4 | |a Genotype & phenotype | |
| 650 | 4 | |a Stem cells | |
| 650 | 4 | |a Correlation analysis | |
| 650 | 4 | |a Hypoxia | |
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| 700 | 0 | |a Gregg L. Semenza |4 oth | |
| 700 | 0 | |a Lisha Xiang |4 oth | |
| 700 | 0 | |a Haiquan Lu |4 oth | |
| 700 | 0 | |a Debangshu Samanta |4 oth | |
| 700 | 0 | |a Jianjun He |4 oth | |
| 700 | 0 | |a John W. Bullen |4 oth | |
| 700 | 0 | |a Chuanzhao Zhang |4 oth | |
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10.1073/pnas.1520032112 doi PQ20160211 (DE-627)OLC1970290986 (DE-599)GBVOLC1970290986 (PRQ)c2229-7007cb15351162f7e7b74de9ab68c4bbc5c9123dc8be539c51740df22898b9780 (KEY)0583363920150000112004506215hif1regulatescd47expressioninbreastcancercellstopr DE-627 ger DE-627 rakwb eng 500 DNB 570 AVZ LING fid BIODIV fid Daniele M. Gilkes verfasserin aut HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Increased expression of CD47 has been reported to enable cancer cells to evade phagocytosis by macrophages and to promote the cancer stem cell phenotype, but the molecular mechanisms regulating CD47 expression have not been determined. Here we report that hypoxia-inducible factor 1 (HIF-1) directly activates transcription of the CD47 gene in hypoxic breast cancer cells. Knockdown of HIF activity or CD47 expression increased the phagocytosis of breast cancer cells by bone marrow-derived macrophages. CD47 expression was increased in mammosphere cultures, which are enriched for cancer stem cells, and CD47 deficiency led to cancer stem cell depletion. Analysis of datasets derived from thousands of patients with breast cancer revealed that CD47 expression was correlated with HIF target gene expression and with patient mortality. Thus, CD47 expression contributes to the lethal breast cancer phenotype that is mediated by HIF-1. Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences Gene expression Complications and side effects Influence Analysis Care and treatment Breast cancer Research Transcriptional coactivators Stem cell research Genotype & phenotype Stem cells Correlation analysis Hypoxia Huimin Zhang oth Gregg L. Semenza oth Lisha Xiang oth Haiquan Lu oth Debangshu Samanta oth Jianjun He oth John W. Bullen oth Chuanzhao Zhang oth Enthalten in Proceedings of the National Academy of Sciences of the United States of America Washington, DC : NAS, 1877 112(2015), 45, Seite E6215-E6223 (DE-627)129505269 (DE-600)209104-5 (DE-576)014909189 0027-8424 nnns volume:112 year:2015 number:45 pages:E6215-E6223 http://dx.doi.org/10.1073/pnas.1520032112 Volltext http://www.pnas.org/content/112/45/E6215.abstract http://www.ncbi.nlm.nih.gov/pubmed/26512116 http://search.proquest.com/docview/1734739230 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT SSG-OPC-FOR GBV_ILN_40 GBV_ILN_59 AR 112 2015 45 E6215-E6223 |
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10.1073/pnas.1520032112 doi PQ20160211 (DE-627)OLC1970290986 (DE-599)GBVOLC1970290986 (PRQ)c2229-7007cb15351162f7e7b74de9ab68c4bbc5c9123dc8be539c51740df22898b9780 (KEY)0583363920150000112004506215hif1regulatescd47expressioninbreastcancercellstopr DE-627 ger DE-627 rakwb eng 500 DNB 570 AVZ LING fid BIODIV fid Daniele M. Gilkes verfasserin aut HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Increased expression of CD47 has been reported to enable cancer cells to evade phagocytosis by macrophages and to promote the cancer stem cell phenotype, but the molecular mechanisms regulating CD47 expression have not been determined. Here we report that hypoxia-inducible factor 1 (HIF-1) directly activates transcription of the CD47 gene in hypoxic breast cancer cells. Knockdown of HIF activity or CD47 expression increased the phagocytosis of breast cancer cells by bone marrow-derived macrophages. CD47 expression was increased in mammosphere cultures, which are enriched for cancer stem cells, and CD47 deficiency led to cancer stem cell depletion. Analysis of datasets derived from thousands of patients with breast cancer revealed that CD47 expression was correlated with HIF target gene expression and with patient mortality. Thus, CD47 expression contributes to the lethal breast cancer phenotype that is mediated by HIF-1. Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences Gene expression Complications and side effects Influence Analysis Care and treatment Breast cancer Research Transcriptional coactivators Stem cell research Genotype & phenotype Stem cells Correlation analysis Hypoxia Huimin Zhang oth Gregg L. Semenza oth Lisha Xiang oth Haiquan Lu oth Debangshu Samanta oth Jianjun He oth John W. Bullen oth Chuanzhao Zhang oth Enthalten in Proceedings of the National Academy of Sciences of the United States of America Washington, DC : NAS, 1877 112(2015), 45, Seite E6215-E6223 (DE-627)129505269 (DE-600)209104-5 (DE-576)014909189 0027-8424 nnns volume:112 year:2015 number:45 pages:E6215-E6223 http://dx.doi.org/10.1073/pnas.1520032112 Volltext http://www.pnas.org/content/112/45/E6215.abstract http://www.ncbi.nlm.nih.gov/pubmed/26512116 http://search.proquest.com/docview/1734739230 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT SSG-OPC-FOR GBV_ILN_40 GBV_ILN_59 AR 112 2015 45 E6215-E6223 |
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10.1073/pnas.1520032112 doi PQ20160211 (DE-627)OLC1970290986 (DE-599)GBVOLC1970290986 (PRQ)c2229-7007cb15351162f7e7b74de9ab68c4bbc5c9123dc8be539c51740df22898b9780 (KEY)0583363920150000112004506215hif1regulatescd47expressioninbreastcancercellstopr DE-627 ger DE-627 rakwb eng 500 DNB 570 AVZ LING fid BIODIV fid Daniele M. Gilkes verfasserin aut HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells 2015 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Increased expression of CD47 has been reported to enable cancer cells to evade phagocytosis by macrophages and to promote the cancer stem cell phenotype, but the molecular mechanisms regulating CD47 expression have not been determined. Here we report that hypoxia-inducible factor 1 (HIF-1) directly activates transcription of the CD47 gene in hypoxic breast cancer cells. Knockdown of HIF activity or CD47 expression increased the phagocytosis of breast cancer cells by bone marrow-derived macrophages. CD47 expression was increased in mammosphere cultures, which are enriched for cancer stem cells, and CD47 deficiency led to cancer stem cell depletion. Analysis of datasets derived from thousands of patients with breast cancer revealed that CD47 expression was correlated with HIF target gene expression and with patient mortality. Thus, CD47 expression contributes to the lethal breast cancer phenotype that is mediated by HIF-1. Nutzungsrecht: © COPYRIGHT 2015 National Academy of Sciences Gene expression Complications and side effects Influence Analysis Care and treatment Breast cancer Research Transcriptional coactivators Stem cell research Genotype & phenotype Stem cells Correlation analysis Hypoxia Huimin Zhang oth Gregg L. Semenza oth Lisha Xiang oth Haiquan Lu oth Debangshu Samanta oth Jianjun He oth John W. Bullen oth Chuanzhao Zhang oth Enthalten in Proceedings of the National Academy of Sciences of the United States of America Washington, DC : NAS, 1877 112(2015), 45, Seite E6215-E6223 (DE-627)129505269 (DE-600)209104-5 (DE-576)014909189 0027-8424 nnns volume:112 year:2015 number:45 pages:E6215-E6223 http://dx.doi.org/10.1073/pnas.1520032112 Volltext http://www.pnas.org/content/112/45/E6215.abstract http://www.ncbi.nlm.nih.gov/pubmed/26512116 http://search.proquest.com/docview/1734739230 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING FID-BIODIV SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-MAT SSG-OPC-FOR GBV_ILN_40 GBV_ILN_59 AR 112 2015 45 E6215-E6223 |
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HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells |
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Increased expression of CD47 has been reported to enable cancer cells to evade phagocytosis by macrophages and to promote the cancer stem cell phenotype, but the molecular mechanisms regulating CD47 expression have not been determined. Here we report that hypoxia-inducible factor 1 (HIF-1) directly activates transcription of the CD47 gene in hypoxic breast cancer cells. Knockdown of HIF activity or CD47 expression increased the phagocytosis of breast cancer cells by bone marrow-derived macrophages. CD47 expression was increased in mammosphere cultures, which are enriched for cancer stem cells, and CD47 deficiency led to cancer stem cell depletion. Analysis of datasets derived from thousands of patients with breast cancer revealed that CD47 expression was correlated with HIF target gene expression and with patient mortality. Thus, CD47 expression contributes to the lethal breast cancer phenotype that is mediated by HIF-1. |
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Increased expression of CD47 has been reported to enable cancer cells to evade phagocytosis by macrophages and to promote the cancer stem cell phenotype, but the molecular mechanisms regulating CD47 expression have not been determined. Here we report that hypoxia-inducible factor 1 (HIF-1) directly activates transcription of the CD47 gene in hypoxic breast cancer cells. Knockdown of HIF activity or CD47 expression increased the phagocytosis of breast cancer cells by bone marrow-derived macrophages. CD47 expression was increased in mammosphere cultures, which are enriched for cancer stem cells, and CD47 deficiency led to cancer stem cell depletion. Analysis of datasets derived from thousands of patients with breast cancer revealed that CD47 expression was correlated with HIF target gene expression and with patient mortality. Thus, CD47 expression contributes to the lethal breast cancer phenotype that is mediated by HIF-1. |
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Increased expression of CD47 has been reported to enable cancer cells to evade phagocytosis by macrophages and to promote the cancer stem cell phenotype, but the molecular mechanisms regulating CD47 expression have not been determined. Here we report that hypoxia-inducible factor 1 (HIF-1) directly activates transcription of the CD47 gene in hypoxic breast cancer cells. Knockdown of HIF activity or CD47 expression increased the phagocytosis of breast cancer cells by bone marrow-derived macrophages. CD47 expression was increased in mammosphere cultures, which are enriched for cancer stem cells, and CD47 deficiency led to cancer stem cell depletion. Analysis of datasets derived from thousands of patients with breast cancer revealed that CD47 expression was correlated with HIF target gene expression and with patient mortality. Thus, CD47 expression contributes to the lethal breast cancer phenotype that is mediated by HIF-1. |
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HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells |
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