Prenatal exposure to endocrine disrupting chemicals and birth weight-A prospective cohort study
Prenatal exposure to endocrine disrupting chemicals may affect fetal development through disruption of hormonal actions and epigenetic modifications, potentially predisposing individuals to later on-set health risks, such as obesity. The objective of this study was to determine associations between...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
de Cock, Marijke [verfasserIn] |
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| Format: |
Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016 |
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| Rechteinformationen: |
Nutzungsrecht: © 2016 Taylor & Francis Group, LLC 2016 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
Enthalten in: Journal of environmental science and health / A - New York, NY : Dekker, 1976, 51(2016), 2, Seite 178-185 |
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| Übergeordnetes Werk: |
volume:51 ; year:2016 ; number:2 ; pages:178-185 |
| Links: |
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| DOI / URN: |
10.1080/10934529.2015.1087753 |
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| 520 | |a Prenatal exposure to endocrine disrupting chemicals may affect fetal development through disruption of hormonal actions and epigenetic modifications, potentially predisposing individuals to later on-set health risks, such as obesity. The objective of this study was to determine associations between biological exposure markers of various endocrine disrupting chemicals and birth weight in a newly established, prospective mother-child cohort in the Netherlands. Birth weight (n = 91) was obtained from birth records, and exposure to dichlorodiphenyldichloroethylene (DDE), three di-2-ethylhexyl phthalate (DEHP) metabolites, polychlorinated biphenyl-153, perfluorooctanesulfonic acid (PFOS), and perfluorooctanoic acid (PFOA) was determined in cord plasma. For DDE, exposure was also measured in breast milk. Linear regression analysis was used to determine associations between compounds and birth weight, which were stratified for gender and adjusted for a priori defined covariates. Increased exposure to DDE was associated with lower birth weight in boys (>95.89 ng L −1 , −325.9 g, 95% CI −634.26 to −17.56), whereas in girls a tendency towards a higher birth weight was observed. Lower birth weights for boys were also observed for high exposure to MECPP, and to a certain extent also for PFOA. MEHHP and PFOS exposure on the other hand were associated with higher birth weights in boys. In girls no effects were observed for these compounds. It can be concluded that prenatal exposure to DDE, perfluorinated alkyl acids, and phthalates was associated with changes in birth weight in this population. Associations were gender specific, and appeared to be non-linear. Since the population was relatively small, results should be interpreted with caution. | ||
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| 650 | 4 | |a Birth weight | |
| 650 | 4 | |a endocrine disruptors | |
| 650 | 4 | |a early life exposure | |
| 650 | 4 | |a Prenatal development | |
| 650 | 4 | |a Chemical compounds | |
| 650 | 4 | |a Human exposure | |
| 700 | 1 | |a De Boer, Michiel R |4 oth | |
| 700 | 1 | |a Lamoree, Marja |4 oth | |
| 700 | 1 | |a Legler, Juliette |4 oth | |
| 700 | 1 | |a Van De Bor, Margot |4 oth | |
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10.1080/10934529.2015.1087753 doi PQ20160430 (DE-627)OLC1970420006 (DE-599)GBVOLC1970420006 (PRQ)c1909-4902ac6e8b33378d05cf62646caa66649c0038a4c602592786e741353bd6db450 (KEY)0005191820160000051000200178prenatalexposuretoendocrinedisruptingchemicalsandb DE-627 ger DE-627 rakwb eng 690 DNB 30.00 bkl de Cock, Marijke verfasserin aut Prenatal exposure to endocrine disrupting chemicals and birth weight-A prospective cohort study 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Prenatal exposure to endocrine disrupting chemicals may affect fetal development through disruption of hormonal actions and epigenetic modifications, potentially predisposing individuals to later on-set health risks, such as obesity. The objective of this study was to determine associations between biological exposure markers of various endocrine disrupting chemicals and birth weight in a newly established, prospective mother-child cohort in the Netherlands. Birth weight (n = 91) was obtained from birth records, and exposure to dichlorodiphenyldichloroethylene (DDE), three di-2-ethylhexyl phthalate (DEHP) metabolites, polychlorinated biphenyl-153, perfluorooctanesulfonic acid (PFOS), and perfluorooctanoic acid (PFOA) was determined in cord plasma. For DDE, exposure was also measured in breast milk. Linear regression analysis was used to determine associations between compounds and birth weight, which were stratified for gender and adjusted for a priori defined covariates. Increased exposure to DDE was associated with lower birth weight in boys (>95.89 ng L −1 , −325.9 g, 95% CI −634.26 to −17.56), whereas in girls a tendency towards a higher birth weight was observed. Lower birth weights for boys were also observed for high exposure to MECPP, and to a certain extent also for PFOA. MEHHP and PFOS exposure on the other hand were associated with higher birth weights in boys. In girls no effects were observed for these compounds. It can be concluded that prenatal exposure to DDE, perfluorinated alkyl acids, and phthalates was associated with changes in birth weight in this population. Associations were gender specific, and appeared to be non-linear. Since the population was relatively small, results should be interpreted with caution. Nutzungsrecht: © 2016 Taylor & Francis Group, LLC 2016 Birth weight endocrine disruptors early life exposure Prenatal development Chemical compounds Human exposure De Boer, Michiel R oth Lamoree, Marja oth Legler, Juliette oth Van De Bor, Margot oth Enthalten in Journal of environmental science and health / A New York, NY : Dekker, 1976 51(2016), 2, Seite 178-185 (DE-627)129447633 (DE-600)196584-0 (DE-576)014814382 0360-1226 nnns volume:51 year:2016 number:2 pages:178-185 http://dx.doi.org/10.1080/10934529.2015.1087753 Volltext http://www.tandfonline.com/doi/abs/10.1080/10934529.2015.1087753 http://search.proquest.com/docview/1752271637 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 30.00 AVZ AR 51 2016 2 178-185 |
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10.1080/10934529.2015.1087753 doi PQ20160430 (DE-627)OLC1970420006 (DE-599)GBVOLC1970420006 (PRQ)c1909-4902ac6e8b33378d05cf62646caa66649c0038a4c602592786e741353bd6db450 (KEY)0005191820160000051000200178prenatalexposuretoendocrinedisruptingchemicalsandb DE-627 ger DE-627 rakwb eng 690 DNB 30.00 bkl de Cock, Marijke verfasserin aut Prenatal exposure to endocrine disrupting chemicals and birth weight-A prospective cohort study 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Prenatal exposure to endocrine disrupting chemicals may affect fetal development through disruption of hormonal actions and epigenetic modifications, potentially predisposing individuals to later on-set health risks, such as obesity. The objective of this study was to determine associations between biological exposure markers of various endocrine disrupting chemicals and birth weight in a newly established, prospective mother-child cohort in the Netherlands. Birth weight (n = 91) was obtained from birth records, and exposure to dichlorodiphenyldichloroethylene (DDE), three di-2-ethylhexyl phthalate (DEHP) metabolites, polychlorinated biphenyl-153, perfluorooctanesulfonic acid (PFOS), and perfluorooctanoic acid (PFOA) was determined in cord plasma. For DDE, exposure was also measured in breast milk. Linear regression analysis was used to determine associations between compounds and birth weight, which were stratified for gender and adjusted for a priori defined covariates. Increased exposure to DDE was associated with lower birth weight in boys (>95.89 ng L −1 , −325.9 g, 95% CI −634.26 to −17.56), whereas in girls a tendency towards a higher birth weight was observed. Lower birth weights for boys were also observed for high exposure to MECPP, and to a certain extent also for PFOA. MEHHP and PFOS exposure on the other hand were associated with higher birth weights in boys. In girls no effects were observed for these compounds. It can be concluded that prenatal exposure to DDE, perfluorinated alkyl acids, and phthalates was associated with changes in birth weight in this population. Associations were gender specific, and appeared to be non-linear. Since the population was relatively small, results should be interpreted with caution. Nutzungsrecht: © 2016 Taylor & Francis Group, LLC 2016 Birth weight endocrine disruptors early life exposure Prenatal development Chemical compounds Human exposure De Boer, Michiel R oth Lamoree, Marja oth Legler, Juliette oth Van De Bor, Margot oth Enthalten in Journal of environmental science and health / A New York, NY : Dekker, 1976 51(2016), 2, Seite 178-185 (DE-627)129447633 (DE-600)196584-0 (DE-576)014814382 0360-1226 nnns volume:51 year:2016 number:2 pages:178-185 http://dx.doi.org/10.1080/10934529.2015.1087753 Volltext http://www.tandfonline.com/doi/abs/10.1080/10934529.2015.1087753 http://search.proquest.com/docview/1752271637 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 30.00 AVZ AR 51 2016 2 178-185 |
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10.1080/10934529.2015.1087753 doi PQ20160430 (DE-627)OLC1970420006 (DE-599)GBVOLC1970420006 (PRQ)c1909-4902ac6e8b33378d05cf62646caa66649c0038a4c602592786e741353bd6db450 (KEY)0005191820160000051000200178prenatalexposuretoendocrinedisruptingchemicalsandb DE-627 ger DE-627 rakwb eng 690 DNB 30.00 bkl de Cock, Marijke verfasserin aut Prenatal exposure to endocrine disrupting chemicals and birth weight-A prospective cohort study 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Prenatal exposure to endocrine disrupting chemicals may affect fetal development through disruption of hormonal actions and epigenetic modifications, potentially predisposing individuals to later on-set health risks, such as obesity. The objective of this study was to determine associations between biological exposure markers of various endocrine disrupting chemicals and birth weight in a newly established, prospective mother-child cohort in the Netherlands. Birth weight (n = 91) was obtained from birth records, and exposure to dichlorodiphenyldichloroethylene (DDE), three di-2-ethylhexyl phthalate (DEHP) metabolites, polychlorinated biphenyl-153, perfluorooctanesulfonic acid (PFOS), and perfluorooctanoic acid (PFOA) was determined in cord plasma. For DDE, exposure was also measured in breast milk. Linear regression analysis was used to determine associations between compounds and birth weight, which were stratified for gender and adjusted for a priori defined covariates. Increased exposure to DDE was associated with lower birth weight in boys (>95.89 ng L −1 , −325.9 g, 95% CI −634.26 to −17.56), whereas in girls a tendency towards a higher birth weight was observed. Lower birth weights for boys were also observed for high exposure to MECPP, and to a certain extent also for PFOA. MEHHP and PFOS exposure on the other hand were associated with higher birth weights in boys. In girls no effects were observed for these compounds. It can be concluded that prenatal exposure to DDE, perfluorinated alkyl acids, and phthalates was associated with changes in birth weight in this population. Associations were gender specific, and appeared to be non-linear. Since the population was relatively small, results should be interpreted with caution. Nutzungsrecht: © 2016 Taylor & Francis Group, LLC 2016 Birth weight endocrine disruptors early life exposure Prenatal development Chemical compounds Human exposure De Boer, Michiel R oth Lamoree, Marja oth Legler, Juliette oth Van De Bor, Margot oth Enthalten in Journal of environmental science and health / A New York, NY : Dekker, 1976 51(2016), 2, Seite 178-185 (DE-627)129447633 (DE-600)196584-0 (DE-576)014814382 0360-1226 nnns volume:51 year:2016 number:2 pages:178-185 http://dx.doi.org/10.1080/10934529.2015.1087753 Volltext http://www.tandfonline.com/doi/abs/10.1080/10934529.2015.1087753 http://search.proquest.com/docview/1752271637 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 30.00 AVZ AR 51 2016 2 178-185 |
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10.1080/10934529.2015.1087753 doi PQ20160430 (DE-627)OLC1970420006 (DE-599)GBVOLC1970420006 (PRQ)c1909-4902ac6e8b33378d05cf62646caa66649c0038a4c602592786e741353bd6db450 (KEY)0005191820160000051000200178prenatalexposuretoendocrinedisruptingchemicalsandb DE-627 ger DE-627 rakwb eng 690 DNB 30.00 bkl de Cock, Marijke verfasserin aut Prenatal exposure to endocrine disrupting chemicals and birth weight-A prospective cohort study 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Prenatal exposure to endocrine disrupting chemicals may affect fetal development through disruption of hormonal actions and epigenetic modifications, potentially predisposing individuals to later on-set health risks, such as obesity. The objective of this study was to determine associations between biological exposure markers of various endocrine disrupting chemicals and birth weight in a newly established, prospective mother-child cohort in the Netherlands. Birth weight (n = 91) was obtained from birth records, and exposure to dichlorodiphenyldichloroethylene (DDE), three di-2-ethylhexyl phthalate (DEHP) metabolites, polychlorinated biphenyl-153, perfluorooctanesulfonic acid (PFOS), and perfluorooctanoic acid (PFOA) was determined in cord plasma. For DDE, exposure was also measured in breast milk. Linear regression analysis was used to determine associations between compounds and birth weight, which were stratified for gender and adjusted for a priori defined covariates. Increased exposure to DDE was associated with lower birth weight in boys (>95.89 ng L −1 , −325.9 g, 95% CI −634.26 to −17.56), whereas in girls a tendency towards a higher birth weight was observed. Lower birth weights for boys were also observed for high exposure to MECPP, and to a certain extent also for PFOA. MEHHP and PFOS exposure on the other hand were associated with higher birth weights in boys. In girls no effects were observed for these compounds. It can be concluded that prenatal exposure to DDE, perfluorinated alkyl acids, and phthalates was associated with changes in birth weight in this population. Associations were gender specific, and appeared to be non-linear. Since the population was relatively small, results should be interpreted with caution. Nutzungsrecht: © 2016 Taylor & Francis Group, LLC 2016 Birth weight endocrine disruptors early life exposure Prenatal development Chemical compounds Human exposure De Boer, Michiel R oth Lamoree, Marja oth Legler, Juliette oth Van De Bor, Margot oth Enthalten in Journal of environmental science and health / A New York, NY : Dekker, 1976 51(2016), 2, Seite 178-185 (DE-627)129447633 (DE-600)196584-0 (DE-576)014814382 0360-1226 nnns volume:51 year:2016 number:2 pages:178-185 http://dx.doi.org/10.1080/10934529.2015.1087753 Volltext http://www.tandfonline.com/doi/abs/10.1080/10934529.2015.1087753 http://search.proquest.com/docview/1752271637 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 30.00 AVZ AR 51 2016 2 178-185 |
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10.1080/10934529.2015.1087753 doi PQ20160430 (DE-627)OLC1970420006 (DE-599)GBVOLC1970420006 (PRQ)c1909-4902ac6e8b33378d05cf62646caa66649c0038a4c602592786e741353bd6db450 (KEY)0005191820160000051000200178prenatalexposuretoendocrinedisruptingchemicalsandb DE-627 ger DE-627 rakwb eng 690 DNB 30.00 bkl de Cock, Marijke verfasserin aut Prenatal exposure to endocrine disrupting chemicals and birth weight-A prospective cohort study 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Prenatal exposure to endocrine disrupting chemicals may affect fetal development through disruption of hormonal actions and epigenetic modifications, potentially predisposing individuals to later on-set health risks, such as obesity. The objective of this study was to determine associations between biological exposure markers of various endocrine disrupting chemicals and birth weight in a newly established, prospective mother-child cohort in the Netherlands. Birth weight (n = 91) was obtained from birth records, and exposure to dichlorodiphenyldichloroethylene (DDE), three di-2-ethylhexyl phthalate (DEHP) metabolites, polychlorinated biphenyl-153, perfluorooctanesulfonic acid (PFOS), and perfluorooctanoic acid (PFOA) was determined in cord plasma. For DDE, exposure was also measured in breast milk. Linear regression analysis was used to determine associations between compounds and birth weight, which were stratified for gender and adjusted for a priori defined covariates. Increased exposure to DDE was associated with lower birth weight in boys (>95.89 ng L −1 , −325.9 g, 95% CI −634.26 to −17.56), whereas in girls a tendency towards a higher birth weight was observed. Lower birth weights for boys were also observed for high exposure to MECPP, and to a certain extent also for PFOA. MEHHP and PFOS exposure on the other hand were associated with higher birth weights in boys. In girls no effects were observed for these compounds. It can be concluded that prenatal exposure to DDE, perfluorinated alkyl acids, and phthalates was associated with changes in birth weight in this population. Associations were gender specific, and appeared to be non-linear. Since the population was relatively small, results should be interpreted with caution. Nutzungsrecht: © 2016 Taylor & Francis Group, LLC 2016 Birth weight endocrine disruptors early life exposure Prenatal development Chemical compounds Human exposure De Boer, Michiel R oth Lamoree, Marja oth Legler, Juliette oth Van De Bor, Margot oth Enthalten in Journal of environmental science and health / A New York, NY : Dekker, 1976 51(2016), 2, Seite 178-185 (DE-627)129447633 (DE-600)196584-0 (DE-576)014814382 0360-1226 nnns volume:51 year:2016 number:2 pages:178-185 http://dx.doi.org/10.1080/10934529.2015.1087753 Volltext http://www.tandfonline.com/doi/abs/10.1080/10934529.2015.1087753 http://search.proquest.com/docview/1752271637 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-PHA SSG-OLC-DE-84 GBV_ILN_70 30.00 AVZ AR 51 2016 2 178-185 |
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prenatal exposure to endocrine disrupting chemicals and birth weight-a prospective cohort study |
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Prenatal exposure to endocrine disrupting chemicals and birth weight-A prospective cohort study |
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Prenatal exposure to endocrine disrupting chemicals may affect fetal development through disruption of hormonal actions and epigenetic modifications, potentially predisposing individuals to later on-set health risks, such as obesity. The objective of this study was to determine associations between biological exposure markers of various endocrine disrupting chemicals and birth weight in a newly established, prospective mother-child cohort in the Netherlands. Birth weight (n = 91) was obtained from birth records, and exposure to dichlorodiphenyldichloroethylene (DDE), three di-2-ethylhexyl phthalate (DEHP) metabolites, polychlorinated biphenyl-153, perfluorooctanesulfonic acid (PFOS), and perfluorooctanoic acid (PFOA) was determined in cord plasma. For DDE, exposure was also measured in breast milk. Linear regression analysis was used to determine associations between compounds and birth weight, which were stratified for gender and adjusted for a priori defined covariates. Increased exposure to DDE was associated with lower birth weight in boys (>95.89 ng L −1 , −325.9 g, 95% CI −634.26 to −17.56), whereas in girls a tendency towards a higher birth weight was observed. Lower birth weights for boys were also observed for high exposure to MECPP, and to a certain extent also for PFOA. MEHHP and PFOS exposure on the other hand were associated with higher birth weights in boys. In girls no effects were observed for these compounds. It can be concluded that prenatal exposure to DDE, perfluorinated alkyl acids, and phthalates was associated with changes in birth weight in this population. Associations were gender specific, and appeared to be non-linear. Since the population was relatively small, results should be interpreted with caution. |
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Prenatal exposure to endocrine disrupting chemicals may affect fetal development through disruption of hormonal actions and epigenetic modifications, potentially predisposing individuals to later on-set health risks, such as obesity. The objective of this study was to determine associations between biological exposure markers of various endocrine disrupting chemicals and birth weight in a newly established, prospective mother-child cohort in the Netherlands. Birth weight (n = 91) was obtained from birth records, and exposure to dichlorodiphenyldichloroethylene (DDE), three di-2-ethylhexyl phthalate (DEHP) metabolites, polychlorinated biphenyl-153, perfluorooctanesulfonic acid (PFOS), and perfluorooctanoic acid (PFOA) was determined in cord plasma. For DDE, exposure was also measured in breast milk. Linear regression analysis was used to determine associations between compounds and birth weight, which were stratified for gender and adjusted for a priori defined covariates. Increased exposure to DDE was associated with lower birth weight in boys (>95.89 ng L −1 , −325.9 g, 95% CI −634.26 to −17.56), whereas in girls a tendency towards a higher birth weight was observed. Lower birth weights for boys were also observed for high exposure to MECPP, and to a certain extent also for PFOA. MEHHP and PFOS exposure on the other hand were associated with higher birth weights in boys. In girls no effects were observed for these compounds. It can be concluded that prenatal exposure to DDE, perfluorinated alkyl acids, and phthalates was associated with changes in birth weight in this population. Associations were gender specific, and appeared to be non-linear. Since the population was relatively small, results should be interpreted with caution. |
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Prenatal exposure to endocrine disrupting chemicals may affect fetal development through disruption of hormonal actions and epigenetic modifications, potentially predisposing individuals to later on-set health risks, such as obesity. The objective of this study was to determine associations between biological exposure markers of various endocrine disrupting chemicals and birth weight in a newly established, prospective mother-child cohort in the Netherlands. Birth weight (n = 91) was obtained from birth records, and exposure to dichlorodiphenyldichloroethylene (DDE), three di-2-ethylhexyl phthalate (DEHP) metabolites, polychlorinated biphenyl-153, perfluorooctanesulfonic acid (PFOS), and perfluorooctanoic acid (PFOA) was determined in cord plasma. For DDE, exposure was also measured in breast milk. Linear regression analysis was used to determine associations between compounds and birth weight, which were stratified for gender and adjusted for a priori defined covariates. Increased exposure to DDE was associated with lower birth weight in boys (>95.89 ng L −1 , −325.9 g, 95% CI −634.26 to −17.56), whereas in girls a tendency towards a higher birth weight was observed. Lower birth weights for boys were also observed for high exposure to MECPP, and to a certain extent also for PFOA. MEHHP and PFOS exposure on the other hand were associated with higher birth weights in boys. In girls no effects were observed for these compounds. It can be concluded that prenatal exposure to DDE, perfluorinated alkyl acids, and phthalates was associated with changes in birth weight in this population. Associations were gender specific, and appeared to be non-linear. Since the population was relatively small, results should be interpreted with caution. |
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