Gating of hippocampal activity, plasticity, and memory by entorhinal cortex long-range inhibition

The cortico-hippocampal circuit is critical for storage of associational memories. Most studies have focused on the role in memory storage of the excitatory projections from entorhinal cortex to hippocampus. However, entorhinal cortex also sends inhibitory projections, whose role in memory storage a...
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Autor*in:	Losonczy, Attila [verfasserIn] Zemelman, Boris V Siegelbaum, Steven A Zaremba, Jeffrey D Hitti, Frederick L Basu, Jayeeta Cheung, Stephanie K

Format:	Artikel
Sprache:	Englisch

Erschienen:	2016

Rechteinformationen:	Nutzungsrecht: Copyright © 2016, American Association for the Advancement of Science.

Schlagwörter:	CA3 Region, Hippocampal - physiology CA1 Region, Hippocampal - physiology Evoked Potentials - physiology Memory, Long-Term - physiology Entorhinal Cortex - physiology Inhibitory Postsynaptic Potentials - physiology Synapses - physiology Neuronal Plasticity - physiology GABAergic Neurons - physiology gamma-Aminobutyric Acid - physiology Dendrites - physiology Pyramidal Cells - physiology

Übergeordnetes Werk:	Enthalten in: Science - Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883, 351(2016), 6269
Übergeordnetes Werk:	volume:351 ; year:2016 ; number:6269

Links:	Volltext Link aufrufen

DOI / URN:	10.1126/science.aaa5694

Katalog-ID:	OLC1970776757

Internformat


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520			\|a The cortico-hippocampal circuit is critical for storage of associational memories. Most studies have focused on the role in memory storage of the excitatory projections from entorhinal cortex to hippocampus. However, entorhinal cortex also sends inhibitory projections, whose role in memory storage and cortico-hippocampal activity remains largely unexplored. We found that these long-range inhibitory projections enhance the specificity of contextual and object memory encoding. At the circuit level, these γ-aminobutyric acid (GABA)-releasing projections target hippocampal inhibitory neurons and thus act as a disinhibitory gate that transiently promotes the excitation of hippocampal CA1 pyramidal neurons by suppressing feedforward inhibition. This enhances the ability of CA1 pyramidal neurons to fire synaptically evoked dendritic spikes and to generate a temporally precise form of heterosynaptic plasticity. Long-range inhibition from entorhinal cortex may thus increase the precision of hippocampal-based long-term memory associations by assessing the salience of mnemonormation to the immediate sensory input.
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650		4	\|a Memory, Long-Term - physiology
650		4	\|a Entorhinal Cortex - physiology
650		4	\|a Inhibitory Postsynaptic Potentials - physiology
650		4	\|a Synapses - physiology
650		4	\|a Neuronal Plasticity - physiology
650		4	\|a GABAergic Neurons - physiology
650		4	\|a gamma-Aminobutyric Acid - physiology
650		4	\|a Dendrites - physiology
650		4	\|a Pyramidal Cells - physiology
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700	1		\|a Basu, Jayeeta \|4 oth
700	1		\|a Cheung, Stephanie K \|4 oth
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allfields	10.1126/science.aaa5694 doi PQ20160212 (DE-627)OLC1970776757 (DE-599)GBVOLC1970776757 (PRQ)c990-af636c844a0c32dd1418ff336484f00ba543a19becbebb4dddfd46b7e0dc67390 (KEY)0063888920160000351626900000gatingofhippocampalactivityplasticityandmemorybyen DE-627 ger DE-627 rakwb eng 500 DNB LING fid Losonczy, Attila verfasserin aut Gating of hippocampal activity, plasticity, and memory by entorhinal cortex long-range inhibition 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The cortico-hippocampal circuit is critical for storage of associational memories. Most studies have focused on the role in memory storage of the excitatory projections from entorhinal cortex to hippocampus. However, entorhinal cortex also sends inhibitory projections, whose role in memory storage and cortico-hippocampal activity remains largely unexplored. We found that these long-range inhibitory projections enhance the specificity of contextual and object memory encoding. At the circuit level, these γ-aminobutyric acid (GABA)-releasing projections target hippocampal inhibitory neurons and thus act as a disinhibitory gate that transiently promotes the excitation of hippocampal CA1 pyramidal neurons by suppressing feedforward inhibition. This enhances the ability of CA1 pyramidal neurons to fire synaptically evoked dendritic spikes and to generate a temporally precise form of heterosynaptic plasticity. Long-range inhibition from entorhinal cortex may thus increase the precision of hippocampal-based long-term memory associations by assessing the salience of mnemonormation to the immediate sensory input. Nutzungsrecht: Copyright © 2016, American Association for the Advancement of Science. CA3 Region, Hippocampal - physiology CA1 Region, Hippocampal - physiology Evoked Potentials - physiology Memory, Long-Term - physiology Entorhinal Cortex - physiology Inhibitory Postsynaptic Potentials - physiology Synapses - physiology Neuronal Plasticity - physiology GABAergic Neurons - physiology gamma-Aminobutyric Acid - physiology Dendrites - physiology Pyramidal Cells - physiology Zemelman, Boris V oth Siegelbaum, Steven A oth Zaremba, Jeffrey D oth Hitti, Frederick L oth Basu, Jayeeta oth Cheung, Stephanie K oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 351(2016), 6269 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:351 year:2016 number:6269 http://dx.doi.org/10.1126/science.aaa5694 Volltext http://www.ncbi.nlm.nih.gov/pubmed/26744409 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 351 2016 6269
spelling	10.1126/science.aaa5694 doi PQ20160212 (DE-627)OLC1970776757 (DE-599)GBVOLC1970776757 (PRQ)c990-af636c844a0c32dd1418ff336484f00ba543a19becbebb4dddfd46b7e0dc67390 (KEY)0063888920160000351626900000gatingofhippocampalactivityplasticityandmemorybyen DE-627 ger DE-627 rakwb eng 500 DNB LING fid Losonczy, Attila verfasserin aut Gating of hippocampal activity, plasticity, and memory by entorhinal cortex long-range inhibition 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The cortico-hippocampal circuit is critical for storage of associational memories. Most studies have focused on the role in memory storage of the excitatory projections from entorhinal cortex to hippocampus. However, entorhinal cortex also sends inhibitory projections, whose role in memory storage and cortico-hippocampal activity remains largely unexplored. We found that these long-range inhibitory projections enhance the specificity of contextual and object memory encoding. At the circuit level, these γ-aminobutyric acid (GABA)-releasing projections target hippocampal inhibitory neurons and thus act as a disinhibitory gate that transiently promotes the excitation of hippocampal CA1 pyramidal neurons by suppressing feedforward inhibition. This enhances the ability of CA1 pyramidal neurons to fire synaptically evoked dendritic spikes and to generate a temporally precise form of heterosynaptic plasticity. Long-range inhibition from entorhinal cortex may thus increase the precision of hippocampal-based long-term memory associations by assessing the salience of mnemonormation to the immediate sensory input. Nutzungsrecht: Copyright © 2016, American Association for the Advancement of Science. CA3 Region, Hippocampal - physiology CA1 Region, Hippocampal - physiology Evoked Potentials - physiology Memory, Long-Term - physiology Entorhinal Cortex - physiology Inhibitory Postsynaptic Potentials - physiology Synapses - physiology Neuronal Plasticity - physiology GABAergic Neurons - physiology gamma-Aminobutyric Acid - physiology Dendrites - physiology Pyramidal Cells - physiology Zemelman, Boris V oth Siegelbaum, Steven A oth Zaremba, Jeffrey D oth Hitti, Frederick L oth Basu, Jayeeta oth Cheung, Stephanie K oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 351(2016), 6269 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:351 year:2016 number:6269 http://dx.doi.org/10.1126/science.aaa5694 Volltext http://www.ncbi.nlm.nih.gov/pubmed/26744409 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 351 2016 6269
allfields_unstemmed	10.1126/science.aaa5694 doi PQ20160212 (DE-627)OLC1970776757 (DE-599)GBVOLC1970776757 (PRQ)c990-af636c844a0c32dd1418ff336484f00ba543a19becbebb4dddfd46b7e0dc67390 (KEY)0063888920160000351626900000gatingofhippocampalactivityplasticityandmemorybyen DE-627 ger DE-627 rakwb eng 500 DNB LING fid Losonczy, Attila verfasserin aut Gating of hippocampal activity, plasticity, and memory by entorhinal cortex long-range inhibition 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The cortico-hippocampal circuit is critical for storage of associational memories. Most studies have focused on the role in memory storage of the excitatory projections from entorhinal cortex to hippocampus. However, entorhinal cortex also sends inhibitory projections, whose role in memory storage and cortico-hippocampal activity remains largely unexplored. We found that these long-range inhibitory projections enhance the specificity of contextual and object memory encoding. At the circuit level, these γ-aminobutyric acid (GABA)-releasing projections target hippocampal inhibitory neurons and thus act as a disinhibitory gate that transiently promotes the excitation of hippocampal CA1 pyramidal neurons by suppressing feedforward inhibition. This enhances the ability of CA1 pyramidal neurons to fire synaptically evoked dendritic spikes and to generate a temporally precise form of heterosynaptic plasticity. Long-range inhibition from entorhinal cortex may thus increase the precision of hippocampal-based long-term memory associations by assessing the salience of mnemonormation to the immediate sensory input. Nutzungsrecht: Copyright © 2016, American Association for the Advancement of Science. CA3 Region, Hippocampal - physiology CA1 Region, Hippocampal - physiology Evoked Potentials - physiology Memory, Long-Term - physiology Entorhinal Cortex - physiology Inhibitory Postsynaptic Potentials - physiology Synapses - physiology Neuronal Plasticity - physiology GABAergic Neurons - physiology gamma-Aminobutyric Acid - physiology Dendrites - physiology Pyramidal Cells - physiology Zemelman, Boris V oth Siegelbaum, Steven A oth Zaremba, Jeffrey D oth Hitti, Frederick L oth Basu, Jayeeta oth Cheung, Stephanie K oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 351(2016), 6269 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:351 year:2016 number:6269 http://dx.doi.org/10.1126/science.aaa5694 Volltext http://www.ncbi.nlm.nih.gov/pubmed/26744409 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 351 2016 6269
allfieldsGer	10.1126/science.aaa5694 doi PQ20160212 (DE-627)OLC1970776757 (DE-599)GBVOLC1970776757 (PRQ)c990-af636c844a0c32dd1418ff336484f00ba543a19becbebb4dddfd46b7e0dc67390 (KEY)0063888920160000351626900000gatingofhippocampalactivityplasticityandmemorybyen DE-627 ger DE-627 rakwb eng 500 DNB LING fid Losonczy, Attila verfasserin aut Gating of hippocampal activity, plasticity, and memory by entorhinal cortex long-range inhibition 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The cortico-hippocampal circuit is critical for storage of associational memories. Most studies have focused on the role in memory storage of the excitatory projections from entorhinal cortex to hippocampus. However, entorhinal cortex also sends inhibitory projections, whose role in memory storage and cortico-hippocampal activity remains largely unexplored. We found that these long-range inhibitory projections enhance the specificity of contextual and object memory encoding. At the circuit level, these γ-aminobutyric acid (GABA)-releasing projections target hippocampal inhibitory neurons and thus act as a disinhibitory gate that transiently promotes the excitation of hippocampal CA1 pyramidal neurons by suppressing feedforward inhibition. This enhances the ability of CA1 pyramidal neurons to fire synaptically evoked dendritic spikes and to generate a temporally precise form of heterosynaptic plasticity. Long-range inhibition from entorhinal cortex may thus increase the precision of hippocampal-based long-term memory associations by assessing the salience of mnemonormation to the immediate sensory input. Nutzungsrecht: Copyright © 2016, American Association for the Advancement of Science. CA3 Region, Hippocampal - physiology CA1 Region, Hippocampal - physiology Evoked Potentials - physiology Memory, Long-Term - physiology Entorhinal Cortex - physiology Inhibitory Postsynaptic Potentials - physiology Synapses - physiology Neuronal Plasticity - physiology GABAergic Neurons - physiology gamma-Aminobutyric Acid - physiology Dendrites - physiology Pyramidal Cells - physiology Zemelman, Boris V oth Siegelbaum, Steven A oth Zaremba, Jeffrey D oth Hitti, Frederick L oth Basu, Jayeeta oth Cheung, Stephanie K oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 351(2016), 6269 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:351 year:2016 number:6269 http://dx.doi.org/10.1126/science.aaa5694 Volltext http://www.ncbi.nlm.nih.gov/pubmed/26744409 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 351 2016 6269
allfieldsSound	10.1126/science.aaa5694 doi PQ20160212 (DE-627)OLC1970776757 (DE-599)GBVOLC1970776757 (PRQ)c990-af636c844a0c32dd1418ff336484f00ba543a19becbebb4dddfd46b7e0dc67390 (KEY)0063888920160000351626900000gatingofhippocampalactivityplasticityandmemorybyen DE-627 ger DE-627 rakwb eng 500 DNB LING fid Losonczy, Attila verfasserin aut Gating of hippocampal activity, plasticity, and memory by entorhinal cortex long-range inhibition 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier The cortico-hippocampal circuit is critical for storage of associational memories. Most studies have focused on the role in memory storage of the excitatory projections from entorhinal cortex to hippocampus. However, entorhinal cortex also sends inhibitory projections, whose role in memory storage and cortico-hippocampal activity remains largely unexplored. We found that these long-range inhibitory projections enhance the specificity of contextual and object memory encoding. At the circuit level, these γ-aminobutyric acid (GABA)-releasing projections target hippocampal inhibitory neurons and thus act as a disinhibitory gate that transiently promotes the excitation of hippocampal CA1 pyramidal neurons by suppressing feedforward inhibition. This enhances the ability of CA1 pyramidal neurons to fire synaptically evoked dendritic spikes and to generate a temporally precise form of heterosynaptic plasticity. Long-range inhibition from entorhinal cortex may thus increase the precision of hippocampal-based long-term memory associations by assessing the salience of mnemonormation to the immediate sensory input. Nutzungsrecht: Copyright © 2016, American Association for the Advancement of Science. CA3 Region, Hippocampal - physiology CA1 Region, Hippocampal - physiology Evoked Potentials - physiology Memory, Long-Term - physiology Entorhinal Cortex - physiology Inhibitory Postsynaptic Potentials - physiology Synapses - physiology Neuronal Plasticity - physiology GABAergic Neurons - physiology gamma-Aminobutyric Acid - physiology Dendrites - physiology Pyramidal Cells - physiology Zemelman, Boris V oth Siegelbaum, Steven A oth Zaremba, Jeffrey D oth Hitti, Frederick L oth Basu, Jayeeta oth Cheung, Stephanie K oth Enthalten in Science Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883 351(2016), 6269 (DE-627)12931482X (DE-600)128410-1 (DE-576)014533189 0036-8075 nnns volume:351 year:2016 number:6269 http://dx.doi.org/10.1126/science.aaa5694 Volltext http://www.ncbi.nlm.nih.gov/pubmed/26744409 GBV_USEFLAG_A SYSFLAG_A GBV_OLC FID-LING SSG-OLC-PHY SSG-OLC-CHE SSG-OLC-MAT SSG-OLC-FOR SSG-OLC-SPO SSG-OLC-IBL SSG-OLC-PHA SSG-OLC-DE-84 SSG-OPC-FOR GBV_ILN_11 GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_47 GBV_ILN_55 GBV_ILN_59 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_92 GBV_ILN_101 GBV_ILN_110 GBV_ILN_120 GBV_ILN_131 GBV_ILN_170 GBV_ILN_171 GBV_ILN_179 GBV_ILN_181 GBV_ILN_211 GBV_ILN_252 GBV_ILN_259 GBV_ILN_290 GBV_ILN_600 GBV_ILN_601 GBV_ILN_647 GBV_ILN_754 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2012 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2116 GBV_ILN_2120 GBV_ILN_2121 GBV_ILN_2173 GBV_ILN_2219 GBV_ILN_2221 GBV_ILN_2279 GBV_ILN_2286 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4036 GBV_ILN_4125 GBV_ILN_4219 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4302 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4310 GBV_ILN_4314 GBV_ILN_4317 GBV_ILN_4318 GBV_ILN_4320 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4700 AR 351 2016 6269
language	English
source	Enthalten in Science 351(2016), 6269 volume:351 year:2016 number:6269
sourceStr	Enthalten in Science 351(2016), 6269 volume:351 year:2016 number:6269
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	CA3 Region, Hippocampal - physiology CA1 Region, Hippocampal - physiology Evoked Potentials - physiology Memory, Long-Term - physiology Entorhinal Cortex - physiology Inhibitory Postsynaptic Potentials - physiology Synapses - physiology Neuronal Plasticity - physiology GABAergic Neurons - physiology gamma-Aminobutyric Acid - physiology Dendrites - physiology Pyramidal Cells - physiology
dewey-raw	500
isfreeaccess_bool	false
container_title	Science
authorswithroles_txt_mv	Losonczy, Attila @@aut@@ Zemelman, Boris V @@oth@@ Siegelbaum, Steven A @@oth@@ Zaremba, Jeffrey D @@oth@@ Hitti, Frederick L @@oth@@ Basu, Jayeeta @@oth@@ Cheung, Stephanie K @@oth@@
publishDateDaySort_date	2016-01-01T00:00:00Z
hierarchy_top_id	12931482X
dewey-sort	3500
id	OLC1970776757
language_de	englisch
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author	Losonczy, Attila
spellingShingle	Losonczy, Attila ddc 500 fid LING misc CA3 Region, Hippocampal - physiology misc CA1 Region, Hippocampal - physiology misc Evoked Potentials - physiology misc Memory, Long-Term - physiology misc Entorhinal Cortex - physiology misc Inhibitory Postsynaptic Potentials - physiology misc Synapses - physiology misc Neuronal Plasticity - physiology misc GABAergic Neurons - physiology misc gamma-Aminobutyric Acid - physiology misc Dendrites - physiology misc Pyramidal Cells - physiology Gating of hippocampal activity, plasticity, and memory by entorhinal cortex long-range inhibition
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topic_title	500 DNB LING fid Gating of hippocampal activity, plasticity, and memory by entorhinal cortex long-range inhibition CA3 Region, Hippocampal - physiology CA1 Region, Hippocampal - physiology Evoked Potentials - physiology Memory, Long-Term - physiology Entorhinal Cortex - physiology Inhibitory Postsynaptic Potentials - physiology Synapses - physiology Neuronal Plasticity - physiology GABAergic Neurons - physiology gamma-Aminobutyric Acid - physiology Dendrites - physiology Pyramidal Cells - physiology
topic	ddc 500 fid LING misc CA3 Region, Hippocampal - physiology misc CA1 Region, Hippocampal - physiology misc Evoked Potentials - physiology misc Memory, Long-Term - physiology misc Entorhinal Cortex - physiology misc Inhibitory Postsynaptic Potentials - physiology misc Synapses - physiology misc Neuronal Plasticity - physiology misc GABAergic Neurons - physiology misc gamma-Aminobutyric Acid - physiology misc Dendrites - physiology misc Pyramidal Cells - physiology
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title	Gating of hippocampal activity, plasticity, and memory by entorhinal cortex long-range inhibition
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title_full	Gating of hippocampal activity, plasticity, and memory by entorhinal cortex long-range inhibition
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title_sort	gating of hippocampal activity, plasticity, and memory by entorhinal cortex long-range inhibition
title_auth	Gating of hippocampal activity, plasticity, and memory by entorhinal cortex long-range inhibition
abstract	The cortico-hippocampal circuit is critical for storage of associational memories. Most studies have focused on the role in memory storage of the excitatory projections from entorhinal cortex to hippocampus. However, entorhinal cortex also sends inhibitory projections, whose role in memory storage and cortico-hippocampal activity remains largely unexplored. We found that these long-range inhibitory projections enhance the specificity of contextual and object memory encoding. At the circuit level, these γ-aminobutyric acid (GABA)-releasing projections target hippocampal inhibitory neurons and thus act as a disinhibitory gate that transiently promotes the excitation of hippocampal CA1 pyramidal neurons by suppressing feedforward inhibition. This enhances the ability of CA1 pyramidal neurons to fire synaptically evoked dendritic spikes and to generate a temporally precise form of heterosynaptic plasticity. Long-range inhibition from entorhinal cortex may thus increase the precision of hippocampal-based long-term memory associations by assessing the salience of mnemonormation to the immediate sensory input.
abstractGer	The cortico-hippocampal circuit is critical for storage of associational memories. Most studies have focused on the role in memory storage of the excitatory projections from entorhinal cortex to hippocampus. However, entorhinal cortex also sends inhibitory projections, whose role in memory storage and cortico-hippocampal activity remains largely unexplored. We found that these long-range inhibitory projections enhance the specificity of contextual and object memory encoding. At the circuit level, these γ-aminobutyric acid (GABA)-releasing projections target hippocampal inhibitory neurons and thus act as a disinhibitory gate that transiently promotes the excitation of hippocampal CA1 pyramidal neurons by suppressing feedforward inhibition. This enhances the ability of CA1 pyramidal neurons to fire synaptically evoked dendritic spikes and to generate a temporally precise form of heterosynaptic plasticity. Long-range inhibition from entorhinal cortex may thus increase the precision of hippocampal-based long-term memory associations by assessing the salience of mnemonormation to the immediate sensory input.
abstract_unstemmed	The cortico-hippocampal circuit is critical for storage of associational memories. Most studies have focused on the role in memory storage of the excitatory projections from entorhinal cortex to hippocampus. However, entorhinal cortex also sends inhibitory projections, whose role in memory storage and cortico-hippocampal activity remains largely unexplored. We found that these long-range inhibitory projections enhance the specificity of contextual and object memory encoding. At the circuit level, these γ-aminobutyric acid (GABA)-releasing projections target hippocampal inhibitory neurons and thus act as a disinhibitory gate that transiently promotes the excitation of hippocampal CA1 pyramidal neurons by suppressing feedforward inhibition. This enhances the ability of CA1 pyramidal neurons to fire synaptically evoked dendritic spikes and to generate a temporally precise form of heterosynaptic plasticity. Long-range inhibition from entorhinal cortex may thus increase the precision of hippocampal-based long-term memory associations by assessing the salience of mnemonormation to the immediate sensory input.
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container_issue	6269
title_short	Gating of hippocampal activity, plasticity, and memory by entorhinal cortex long-range inhibition
url	http://dx.doi.org/10.1126/science.aaa5694 http://www.ncbi.nlm.nih.gov/pubmed/26744409
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author2	Zemelman, Boris V Siegelbaum, Steven A Zaremba, Jeffrey D Hitti, Frederick L Basu, Jayeeta Cheung, Stephanie K
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up_date	2024-07-03T16:47:28.298Z
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Most studies have focused on the role in memory storage of the excitatory projections from entorhinal cortex to hippocampus. However, entorhinal cortex also sends inhibitory projections, whose role in memory storage and cortico-hippocampal activity remains largely unexplored. We found that these long-range inhibitory projections enhance the specificity of contextual and object memory encoding. At the circuit level, these γ-aminobutyric acid (GABA)-releasing projections target hippocampal inhibitory neurons and thus act as a disinhibitory gate that transiently promotes the excitation of hippocampal CA1 pyramidal neurons by suppressing feedforward inhibition. This enhances the ability of CA1 pyramidal neurons to fire synaptically evoked dendritic spikes and to generate a temporally precise form of heterosynaptic plasticity. Long-range inhibition from entorhinal cortex may thus increase the precision of hippocampal-based long-term memory associations by assessing the salience of mnemonormation to the immediate sensory input.</subfield></datafield><datafield tag="540" ind1=" " ind2=" "><subfield code="a">Nutzungsrecht: Copyright © 2016, American Association for the Advancement of Science.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">CA3 Region, Hippocampal - physiology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">CA1 Region, Hippocampal - physiology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Evoked Potentials - physiology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Memory, Long-Term - physiology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Entorhinal Cortex - physiology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Inhibitory Postsynaptic Potentials - physiology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Synapses - physiology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Neuronal Plasticity - physiology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">GABAergic Neurons - physiology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">gamma-Aminobutyric Acid - physiology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Dendrites - physiology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pyramidal Cells - physiology</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zemelman, Boris V</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Siegelbaum, Steven A</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zaremba, Jeffrey D</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hitti, Frederick L</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Basu, Jayeeta</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cheung, Stephanie K</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Science</subfield><subfield code="d">Washington, DC : AAAS, American Assoc. for the Advancement of Science, 1883</subfield><subfield code="g">351(2016), 6269</subfield><subfield code="w">(DE-627)12931482X</subfield><subfield code="w">(DE-600)128410-1</subfield><subfield code="w">(DE-576)014533189</subfield><subfield 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Gating of hippocampal activity, plasticity, and memory by entorhinal cortex long-range inhibition

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