Arsenic projects in SE Asia
Early life exposure to inorganic arsenic is associated with a wide range of malignant and chronic disease outcomes in humans. Prenatal arsenic exposure may give rise to adverse effects on child health and development as arsenic readily passes through the placenta in human beings. The impact of mater...
Ausführliche Beschreibung
Autor*in: |
Panida Navasumrit [verfasserIn] |
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Format: |
Artikel |
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Sprache: |
Englisch |
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2016 |
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Schlagwörter: |
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Übergeordnetes Werk: |
Enthalten in: Reviews on environmental health - Berlin : de Gruyter, 1972, 31(2016), 1, Seite 11-12 |
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Übergeordnetes Werk: |
volume:31 ; year:2016 ; number:1 ; pages:11-12 |
Links: |
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DOI / URN: |
10.1515/reveh-2015-0068 |
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OLC197292169X |
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10.1515/reveh-2015-0068 doi PQ20160430 (DE-627)OLC197292169X (DE-599)GBVOLC197292169X (PRQ)walterdegruyter_journals_10_1515_reveh_2015_0068311110 (KEY)0081067320160000031000100011arsenicprojectsinseasia DE-627 ger DE-627 rakwb eng 360 333.7 DNB 333.7 AVZ 43.00 bkl Panida Navasumrit verfasserin aut Arsenic projects in SE Asia 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Early life exposure to inorganic arsenic is associated with a wide range of malignant and chronic disease outcomes in humans. Prenatal arsenic exposure may give rise to adverse effects on child health and development as arsenic readily passes through the placenta in human beings. The impact of maternal arsenic exposure on fetal gene expression was conducted in pregnant women living in Southern Thailand. Arsenic exposed newborns had significantly higher levels of arsenic in cord blood, and a set of genes associated with numerous biological pathways, including cell signaling, apoptosis, inflammatory and stress response. A slight increase in promoter methylation of in cord blood lymphocytes which correlated with arsenic accumulation in nails was observed in these exposed newborns. A follow-up study on these exposed children showed a significant increase in oxidative DNA damage, measured as 8-hydroxydeoxyguanosine (8-OHdG) in saliva. In addition, levels of urinary 8-OHdG excretion and salivary expression were significantly decreased in exposed children suggesting a defect in repair of 8-OHdG in arsenic-exposed children. Our study indicates that prenatal arsenic and continued exposure through early childhood can trigger various genetic and epigenetic alterations that may lead to disease development later in life. prenatal exposure expression promoter methylation of arsenic oxidative DNA damage 8-hydroxydeoxyguanosine Krittinee Chaisatra oth Mathuros Ruchirawat oth Enthalten in Reviews on environmental health Berlin : de Gruyter, 1972 31(2016), 1, Seite 11-12 (DE-627)12938884X (DE-600)184450-7 (DE-576)455168199 0048-7554 nnns volume:31 year:2016 number:1 pages:11-12 http://dx.doi.org/10.1515/reveh-2015-0068 Volltext http://www.degruyter.com/doi/10.1515/reveh-2015-0068 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW GBV_ILN_267 GBV_ILN_4012 GBV_ILN_4219 GBV_ILN_4277 43.00 AVZ AR 31 2016 1 11-12 |
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10.1515/reveh-2015-0068 doi PQ20160430 (DE-627)OLC197292169X (DE-599)GBVOLC197292169X (PRQ)walterdegruyter_journals_10_1515_reveh_2015_0068311110 (KEY)0081067320160000031000100011arsenicprojectsinseasia DE-627 ger DE-627 rakwb eng 360 333.7 DNB 333.7 AVZ 43.00 bkl Panida Navasumrit verfasserin aut Arsenic projects in SE Asia 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Early life exposure to inorganic arsenic is associated with a wide range of malignant and chronic disease outcomes in humans. Prenatal arsenic exposure may give rise to adverse effects on child health and development as arsenic readily passes through the placenta in human beings. The impact of maternal arsenic exposure on fetal gene expression was conducted in pregnant women living in Southern Thailand. Arsenic exposed newborns had significantly higher levels of arsenic in cord blood, and a set of genes associated with numerous biological pathways, including cell signaling, apoptosis, inflammatory and stress response. A slight increase in promoter methylation of in cord blood lymphocytes which correlated with arsenic accumulation in nails was observed in these exposed newborns. A follow-up study on these exposed children showed a significant increase in oxidative DNA damage, measured as 8-hydroxydeoxyguanosine (8-OHdG) in saliva. In addition, levels of urinary 8-OHdG excretion and salivary expression were significantly decreased in exposed children suggesting a defect in repair of 8-OHdG in arsenic-exposed children. Our study indicates that prenatal arsenic and continued exposure through early childhood can trigger various genetic and epigenetic alterations that may lead to disease development later in life. prenatal exposure expression promoter methylation of arsenic oxidative DNA damage 8-hydroxydeoxyguanosine Krittinee Chaisatra oth Mathuros Ruchirawat oth Enthalten in Reviews on environmental health Berlin : de Gruyter, 1972 31(2016), 1, Seite 11-12 (DE-627)12938884X (DE-600)184450-7 (DE-576)455168199 0048-7554 nnns volume:31 year:2016 number:1 pages:11-12 http://dx.doi.org/10.1515/reveh-2015-0068 Volltext http://www.degruyter.com/doi/10.1515/reveh-2015-0068 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW GBV_ILN_267 GBV_ILN_4012 GBV_ILN_4219 GBV_ILN_4277 43.00 AVZ AR 31 2016 1 11-12 |
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10.1515/reveh-2015-0068 doi PQ20160430 (DE-627)OLC197292169X (DE-599)GBVOLC197292169X (PRQ)walterdegruyter_journals_10_1515_reveh_2015_0068311110 (KEY)0081067320160000031000100011arsenicprojectsinseasia DE-627 ger DE-627 rakwb eng 360 333.7 DNB 333.7 AVZ 43.00 bkl Panida Navasumrit verfasserin aut Arsenic projects in SE Asia 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Early life exposure to inorganic arsenic is associated with a wide range of malignant and chronic disease outcomes in humans. Prenatal arsenic exposure may give rise to adverse effects on child health and development as arsenic readily passes through the placenta in human beings. The impact of maternal arsenic exposure on fetal gene expression was conducted in pregnant women living in Southern Thailand. Arsenic exposed newborns had significantly higher levels of arsenic in cord blood, and a set of genes associated with numerous biological pathways, including cell signaling, apoptosis, inflammatory and stress response. A slight increase in promoter methylation of in cord blood lymphocytes which correlated with arsenic accumulation in nails was observed in these exposed newborns. A follow-up study on these exposed children showed a significant increase in oxidative DNA damage, measured as 8-hydroxydeoxyguanosine (8-OHdG) in saliva. In addition, levels of urinary 8-OHdG excretion and salivary expression were significantly decreased in exposed children suggesting a defect in repair of 8-OHdG in arsenic-exposed children. Our study indicates that prenatal arsenic and continued exposure through early childhood can trigger various genetic and epigenetic alterations that may lead to disease development later in life. prenatal exposure expression promoter methylation of arsenic oxidative DNA damage 8-hydroxydeoxyguanosine Krittinee Chaisatra oth Mathuros Ruchirawat oth Enthalten in Reviews on environmental health Berlin : de Gruyter, 1972 31(2016), 1, Seite 11-12 (DE-627)12938884X (DE-600)184450-7 (DE-576)455168199 0048-7554 nnns volume:31 year:2016 number:1 pages:11-12 http://dx.doi.org/10.1515/reveh-2015-0068 Volltext http://www.degruyter.com/doi/10.1515/reveh-2015-0068 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW GBV_ILN_267 GBV_ILN_4012 GBV_ILN_4219 GBV_ILN_4277 43.00 AVZ AR 31 2016 1 11-12 |
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10.1515/reveh-2015-0068 doi PQ20160430 (DE-627)OLC197292169X (DE-599)GBVOLC197292169X (PRQ)walterdegruyter_journals_10_1515_reveh_2015_0068311110 (KEY)0081067320160000031000100011arsenicprojectsinseasia DE-627 ger DE-627 rakwb eng 360 333.7 DNB 333.7 AVZ 43.00 bkl Panida Navasumrit verfasserin aut Arsenic projects in SE Asia 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Early life exposure to inorganic arsenic is associated with a wide range of malignant and chronic disease outcomes in humans. Prenatal arsenic exposure may give rise to adverse effects on child health and development as arsenic readily passes through the placenta in human beings. The impact of maternal arsenic exposure on fetal gene expression was conducted in pregnant women living in Southern Thailand. Arsenic exposed newborns had significantly higher levels of arsenic in cord blood, and a set of genes associated with numerous biological pathways, including cell signaling, apoptosis, inflammatory and stress response. A slight increase in promoter methylation of in cord blood lymphocytes which correlated with arsenic accumulation in nails was observed in these exposed newborns. A follow-up study on these exposed children showed a significant increase in oxidative DNA damage, measured as 8-hydroxydeoxyguanosine (8-OHdG) in saliva. In addition, levels of urinary 8-OHdG excretion and salivary expression were significantly decreased in exposed children suggesting a defect in repair of 8-OHdG in arsenic-exposed children. Our study indicates that prenatal arsenic and continued exposure through early childhood can trigger various genetic and epigenetic alterations that may lead to disease development later in life. prenatal exposure expression promoter methylation of arsenic oxidative DNA damage 8-hydroxydeoxyguanosine Krittinee Chaisatra oth Mathuros Ruchirawat oth Enthalten in Reviews on environmental health Berlin : de Gruyter, 1972 31(2016), 1, Seite 11-12 (DE-627)12938884X (DE-600)184450-7 (DE-576)455168199 0048-7554 nnns volume:31 year:2016 number:1 pages:11-12 http://dx.doi.org/10.1515/reveh-2015-0068 Volltext http://www.degruyter.com/doi/10.1515/reveh-2015-0068 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW GBV_ILN_267 GBV_ILN_4012 GBV_ILN_4219 GBV_ILN_4277 43.00 AVZ AR 31 2016 1 11-12 |
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10.1515/reveh-2015-0068 doi PQ20160430 (DE-627)OLC197292169X (DE-599)GBVOLC197292169X (PRQ)walterdegruyter_journals_10_1515_reveh_2015_0068311110 (KEY)0081067320160000031000100011arsenicprojectsinseasia DE-627 ger DE-627 rakwb eng 360 333.7 DNB 333.7 AVZ 43.00 bkl Panida Navasumrit verfasserin aut Arsenic projects in SE Asia 2016 Text txt rdacontent ohne Hilfsmittel zu benutzen n rdamedia Band nc rdacarrier Early life exposure to inorganic arsenic is associated with a wide range of malignant and chronic disease outcomes in humans. Prenatal arsenic exposure may give rise to adverse effects on child health and development as arsenic readily passes through the placenta in human beings. The impact of maternal arsenic exposure on fetal gene expression was conducted in pregnant women living in Southern Thailand. Arsenic exposed newborns had significantly higher levels of arsenic in cord blood, and a set of genes associated with numerous biological pathways, including cell signaling, apoptosis, inflammatory and stress response. A slight increase in promoter methylation of in cord blood lymphocytes which correlated with arsenic accumulation in nails was observed in these exposed newborns. A follow-up study on these exposed children showed a significant increase in oxidative DNA damage, measured as 8-hydroxydeoxyguanosine (8-OHdG) in saliva. In addition, levels of urinary 8-OHdG excretion and salivary expression were significantly decreased in exposed children suggesting a defect in repair of 8-OHdG in arsenic-exposed children. Our study indicates that prenatal arsenic and continued exposure through early childhood can trigger various genetic and epigenetic alterations that may lead to disease development later in life. prenatal exposure expression promoter methylation of arsenic oxidative DNA damage 8-hydroxydeoxyguanosine Krittinee Chaisatra oth Mathuros Ruchirawat oth Enthalten in Reviews on environmental health Berlin : de Gruyter, 1972 31(2016), 1, Seite 11-12 (DE-627)12938884X (DE-600)184450-7 (DE-576)455168199 0048-7554 nnns volume:31 year:2016 number:1 pages:11-12 http://dx.doi.org/10.1515/reveh-2015-0068 Volltext http://www.degruyter.com/doi/10.1515/reveh-2015-0068 GBV_USEFLAG_A SYSFLAG_A GBV_OLC SSG-OLC-UMW GBV_ILN_267 GBV_ILN_4012 GBV_ILN_4219 GBV_ILN_4277 43.00 AVZ AR 31 2016 1 11-12 |
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Panida Navasumrit |
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arsenic projects in se asia |
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Arsenic projects in SE Asia |
abstract |
Early life exposure to inorganic arsenic is associated with a wide range of malignant and chronic disease outcomes in humans. Prenatal arsenic exposure may give rise to adverse effects on child health and development as arsenic readily passes through the placenta in human beings. The impact of maternal arsenic exposure on fetal gene expression was conducted in pregnant women living in Southern Thailand. Arsenic exposed newborns had significantly higher levels of arsenic in cord blood, and a set of genes associated with numerous biological pathways, including cell signaling, apoptosis, inflammatory and stress response. A slight increase in promoter methylation of in cord blood lymphocytes which correlated with arsenic accumulation in nails was observed in these exposed newborns. A follow-up study on these exposed children showed a significant increase in oxidative DNA damage, measured as 8-hydroxydeoxyguanosine (8-OHdG) in saliva. In addition, levels of urinary 8-OHdG excretion and salivary expression were significantly decreased in exposed children suggesting a defect in repair of 8-OHdG in arsenic-exposed children. Our study indicates that prenatal arsenic and continued exposure through early childhood can trigger various genetic and epigenetic alterations that may lead to disease development later in life. |
abstractGer |
Early life exposure to inorganic arsenic is associated with a wide range of malignant and chronic disease outcomes in humans. Prenatal arsenic exposure may give rise to adverse effects on child health and development as arsenic readily passes through the placenta in human beings. The impact of maternal arsenic exposure on fetal gene expression was conducted in pregnant women living in Southern Thailand. Arsenic exposed newborns had significantly higher levels of arsenic in cord blood, and a set of genes associated with numerous biological pathways, including cell signaling, apoptosis, inflammatory and stress response. A slight increase in promoter methylation of in cord blood lymphocytes which correlated with arsenic accumulation in nails was observed in these exposed newborns. A follow-up study on these exposed children showed a significant increase in oxidative DNA damage, measured as 8-hydroxydeoxyguanosine (8-OHdG) in saliva. In addition, levels of urinary 8-OHdG excretion and salivary expression were significantly decreased in exposed children suggesting a defect in repair of 8-OHdG in arsenic-exposed children. Our study indicates that prenatal arsenic and continued exposure through early childhood can trigger various genetic and epigenetic alterations that may lead to disease development later in life. |
abstract_unstemmed |
Early life exposure to inorganic arsenic is associated with a wide range of malignant and chronic disease outcomes in humans. Prenatal arsenic exposure may give rise to adverse effects on child health and development as arsenic readily passes through the placenta in human beings. The impact of maternal arsenic exposure on fetal gene expression was conducted in pregnant women living in Southern Thailand. Arsenic exposed newborns had significantly higher levels of arsenic in cord blood, and a set of genes associated with numerous biological pathways, including cell signaling, apoptosis, inflammatory and stress response. A slight increase in promoter methylation of in cord blood lymphocytes which correlated with arsenic accumulation in nails was observed in these exposed newborns. A follow-up study on these exposed children showed a significant increase in oxidative DNA damage, measured as 8-hydroxydeoxyguanosine (8-OHdG) in saliva. In addition, levels of urinary 8-OHdG excretion and salivary expression were significantly decreased in exposed children suggesting a defect in repair of 8-OHdG in arsenic-exposed children. Our study indicates that prenatal arsenic and continued exposure through early childhood can trigger various genetic and epigenetic alterations that may lead to disease development later in life. |
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title_short |
Arsenic projects in SE Asia |
url |
http://dx.doi.org/10.1515/reveh-2015-0068 http://www.degruyter.com/doi/10.1515/reveh-2015-0068 |
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Krittinee Chaisatra Mathuros Ruchirawat |
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